分离自皮肤细胞的组合物及其使用方法

专利名称：：分离自皮肤细胞的组合物及其使用方法
技术领域：
：本发明涉及编码多肽的多核苷酸、在皮肤细胞中表达的多肽以及治疗患者的各种方法，所述治疗方法包括给予本发明的多肽或多核苷酸。发明背景皮肤是肌体的最大器官，并起保护层作用。在严重烧伤人员发生的皮肤损伤可能由于缺乏对抗外部微生物感染的屏障以及体温和体液的下降和流失而导致死亡。皮肤组织由若干层组成，最外层是由基底膜支撑并覆盖在真皮上面的表皮。真皮下面是疏松的结缔组织和覆盖肌肉或骨组织的筋膜。皮肤是自我更新组织，因为皮肤细胞不断形成和脱落。表皮最深层的细胞是基底细胞，其中富含能够复制的细胞。这种复制细胞被称为祖细胞或干细胞。复制细胞又产生称为‘移行放大细胞(transitamplifyiingcell)’的子细胞。随着这些细胞由基底层转移到表皮的更表面层而分化成熟为角质细胞(成熟皮肤细胞)。在此过程中，角质细胞发生角质化并最终由皮肤表面脱落。表皮中的其它细胞包括合成黑色素的黑素细胞，黑色素是负责抗日照的保护性色素。朗格汉斯细胞也位于表皮中，起着加工外源蛋白以呈递给免疫系统的细胞作用。真皮含有神经、血管和淋巴管、纤维组织和脂肪组织。在真皮中有成纤维细胞、巨噬细胞和肥大细胞。汗腺或皮脂腺以及毛囊穿过表皮和真皮。每根毛发都起源自一个毛囊。当拔出毛发时，毛发会在毛囊的真皮乳头控制下的上皮细胞再生出来。当皮肤表面破裂时，例如受伤时，干细胞增殖而子代角质细胞迁移至伤口重新弥合组织。因此皮肤细胞具有在创伤作用下激活的基因。这些基因的产物包括数种生长因子，例如介导皮肤细胞增殖的表皮生长因子。可以将在皮肤中激活的基因和这些基因的蛋白产物开发为治疗皮肤损伤的药物。皮肤细胞产生的其它生长因子也可以影响其它类型细胞的生长。因为皮肤癌是一种皮肤细胞生长性紊乱，所以皮肤产生的调节细胞生长的蛋白可以开发为治疗皮肤癌的药物。皮肤产生的调节黑色素产生的蛋白可以用作保护皮肤抵抗有害日照作用的药物。已知角质细胞分泌细胞因子并表达各种细胞表面蛋白。细胞因子和细胞表面分子是在抗感染的炎症反应以及累及皮肤的自身免疫疾病中起重要作用的蛋白。因此，皮肤细胞表达的基因及其蛋白产物可开发成治疗累及皮肤的炎症性疾病的药物。毛发是人体个性的重要部分。皮肤疾病可导致毛发受损。斑秃是一种特征为头皮毛发片状缺损的疾病。全秃是癌症药物治疗的副作用。毛发的生长发育是由在皮肤和真皮乳头中表达的基因的作用介导的。这样的基因及其蛋白产物可有效开发为治疗毛囊性疾病的药物。需要新型治疗法来促进皮肤伤口的愈合、防止脱发、增强毛发再生或去除毛发以及更有效而没有副作用地治疗自身免疫性皮肤病和炎症性皮肤病。还需要对皮肤癌的更有效治疗方法。因此本领域仍然需要鉴定和分离编码在皮肤中表达的蛋白的基因，用于开发治疗包括皮肤相关疾病在内的疾病的治疗药物。发明概述本发明提供在皮肤细胞中表达的多肽和编码这些多肽的多核苷酸、包含这些多核苷酸的表达载体和宿主细胞，以及它们的使用方法。在具体的实施方案中，提供分离多核苷酸，所述分离多核苷酸包含选自以下的DNA序列(a)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述的序列；(b)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的互补序列；(c)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向互补序列；(d)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向序列；(e)与(a)-(d)序列相同的可能性为99％的序列；以及(f)与(a)-(d)序列的同一性至少为50％、75％或90％的序列。在其它实施方案中，本发明提供分离多肽以及编码这样的多肽的分离多核苷酸，所述分离多肽包含选自以下的氨基酸序列(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；以及(b)与SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供序列的同一性至少为50％、75％或90％的序列。还提供包括含选自以下的氨基酸序列的多肽的至少一个功能部分的分离多肽(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；以及(b)与SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465序列的同一性至少为50％、75％或90％的序列。在相关实施方案中，本发明提供包含上述多核苷酸的表达载体以及用所述载体转化的宿主细胞。进一方面，本发明提供刺激患者角质细胞生长和移动、抑制上皮性癌细胞生长、抑制肿瘤血管发生和血管形成或调节血管生长的方法，包括给予所述患者包含分离多肽的组合物，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO187、196、342、343、395、397和398提供的序列；和(b)与SEQIDNO187、196、342、343、395、397和398提供序列的同一性为至少50％、75％或90％的序列。本发明还提供调节患者皮肤炎症的方法，该方法包括给予所述患者包含分离多肽的组合物，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO338和347提供的序列；和(b)与SEQIDNO338和347提供序列的同一性至少为50％、75％或90％的序列。再一方面，本发明提供刺激患者上皮细胞生长的方法。所述方法包括给予所述患者包含分离多肽的组合物，所述分离多肽包括选自以下的氨基酸序列(a)SEQIDNO129和348提供的序列；和(b)与SEQIDNO129和348提供序列的同一性至少为50％、75％或90％的序列。再一方面，本发明提供抑制HIV-1结合患者白细胞、治疗炎性疾病或治疗癌症的方法，所述方法包括给予所述患者包含分离多肽的组合物，所述分离多肽包括选自以下的氨基酸序列(a)SEQIDNO340、344、345和346提供的序列；和(b)与SEQIDNO340、344、345和346提供序列的同一性至少为50％、75％或90％的序列。如下详述，本发明的分离多核苷酸和分离多肽可有效用于制备治疗皮肤疾病的治疗药物。参照以下更详细的描述可充分理解本发明的上述特征和其它特征以及获得它们的方法。如同每个参考文献都单独结合到本文中一样，本文公开的所有参考文献都通过引用整体结合到本文中。附图简述图1图示huTR1Mrna在人组织中分布的RNA分析结果。图解He，心脏；Br，大脑；Pl，胎盘；Lu，肺；Li，肝；SM，骨骼肌；Ki，肾；Sp，脾；Th，胸腺；Pr，前列腺；Ov，卵巢。图2图示muTR1a和huTR1a的MAP激酶测定结果。如正文所述加入MuTR1a(500ng/ml)、huTR1a(100ng/ml)或LPS(3pg/ml)。图3图示muTR1a对新生儿阴茎包皮角质细胞生长的刺激作用。图4图示muTR1a和huTR1a对转化的人角质细胞细胞系HaCaT生长的刺激作用。图5图示muTR1a和huTR1a对人上皮癌细胞系A431生长的抑制作用。图6图示KS2a抑制IL-2诱导的伴刀豆球蛋白A刺激的小鼠脾细胞生长。图7图示KS3a和脱铁运铁蛋白组合对大鼠肠上皮细胞(IEC-18)生长的刺激作用。图8图示说明TR-1(100ng/ml)、muKS1(100ng/ml)、SDF1α(100ng/ml)和fMLP(10μM)对人PBMC的氧化爆发作用。图9图示muKS1和SDF1α对THP-1细胞的趋化作用。图10图示在腹膜内注射muKS1(50μg)、GV14B(50μg)和PBS后在C3H/HeJ小鼠中诱导的细胞浸润。图11证实huTR1a在CV1/EBNA和HeLa细胞系中诱导ERK1和ERK2的磷酸化作用。图12图示用muTR1、huTR1、huTGFα和PBS(均为100ng/ml)刺激后huTR1mRNA在HeLa细胞中的表达。图13图示muTR1a在PC-12(图13A)和HaCaT(图13B)细胞中对SRE的激活作用。图14图示抗EGF受体抗体对huTR1a介导的HaCaT细胞生长的抑制作用。图15A利用单字母代码图示KS2cDNA的核苷酸序列(SEQIDNO464)以及推断的氨基酸序列(SEQIDNO465)。用负数标示5′UTR。下划线的NH2-末端氨基酸为预期前导序列，***表示终止密码子。双下划线标示多腺苷酸化信号。图15B图示比较KS1的完整可读框(在图15B中称为KLF-1)与其人同源物BRAK和小鼠α-趋化因子mCrg-2、mMig、mSDF-1、mBLC、mMIP2、mKC和mLIX。对于趋化因子而言，以前尚未描述过在KS1和BRAK的半胱氨酸3和半胱氨酸4之间存在另外5个残基。发明详述一个方面，本发明提供分离自哺乳动物皮肤细胞的多核苷酸。本文使用的术语“多核苷酸”是指单链或双链的脱氧核糖核苷酸碱基聚合物或核糖核苷酸碱基聚合物，包括有义链和反义链的DNA和RNA分子。该术语包括cDNA、基因组DNA、重组DNA以及全部或部分合成的核酸分子。多核苷酸可以包括完整的基因或其部分。基因是编码功能蛋白或RNA分子的DNA序列。有效反义多核苷酸可以包括相应的多核苷酸片段，因此“多核苷酸”的定义包括所有有效的反义片段。反义多核苷酸以及涉及反义多核苷酸的技术是本领域众所周知的，例如Robinson-Benion等，“反义技术”，MethodsinEnzymol.254(23)363-375，1995；和Kawasaki等，Artific.Organs20(8)836-848，1996中有关于它的介绍。可以在合适的严格条件下，使用cDNA序列的全部或部分作为筛选合适文库的探针，通过标准DNA/DNA杂交技术完成对基因组DNA和异钟DNA的鉴定。或者，可以使用利用寡核苷酸引物的PCR技术扩增和鉴定基因组序列和cDNA序列，所述寡核苷酸引物是根据已知基因组DNA、cDNA和蛋白序列设计的。可以通过常规的合成方法生产相当于鉴定序列和变异体的合成DNA。正如本领域常规使用这些术语一样，本发明提供的所有多核苷酸都是分离纯化的。在具体实施方案中，本发明的多核苷酸包含选自以下序列的DNA序列SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464提供的序列以及SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464序列的变异体。还提供包括所述DNA序列的互补序列、反向互补序列或反向序列以及这些序列的变异体的多核苷酸。以下实例最清晰地阐述了本文使用的术语“互补序列”、“反向互补序列”和“反向序列”的定义。对于序列5′AGGACC3′，互补序列、反向互补序列和反向序列如下互补序列3′TCCTGG5′反向互补序列3′GGTCCT5′反向序列5′CCAGGA3′。另一方面，本发明提供由上述多核苷酸编码或部分编码的分离多肽。本文使用的术语“多肽”包含任意长度的氨基酸链，包括全长蛋白，其中所述氨基酸残基与共价肽键相连。本文使用的术语“多核苷酸编码的多肽”包括由包含本文提供的部分分离DNA序列的多核苷酸编码的多肽。在具体的实施方案中，本发明的多肽包括选自以下序列的氨基酸序列SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列以及这些序列的变异体。本发明的多肽可以通过将编码所述多肽的DNA序列插入到表达载体中并在合适宿主中表达所述多肽而重组产生。可以使用本领域普通技术人员已知的各种表达载体中的任一种。表达可以在用包含编码重组多肽的DNA分子的表达载体转化或转染的任何合适宿主细胞中进行。合适的宿主细胞包括原核生物细胞、酵母和高等真核细胞。优选使用的宿主细胞是大肠杆菌、昆虫、酵母或哺乳动物细胞系(诸如COS或CHO)。以此方式表达的DNA序列可以编码天然多肽、其部分或其其它变异体。在一个相关方面，提供至少包含多肽的功能部分的多肽，所述多肽具有选自以下序列的氨基酸序列SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列及其变异体。本文使用的多肽的“功能部分”是包含影响所述多肽功能必需的活性部位的部分，例如能够结合一个或多个反应物的分子部分。所述活性部位可以由存在于一个或多个多肽链上的几个独立部分组成，一般具有高结合亲和力。首先通过化学或酶促消化多肽或突变分析编码多肽的多核苷酸以及随后表达获得的突变多肽制备多肽的片段，可鉴定所述多肽的各个功能部分。然后使用例如以下提供的典型测定，测试所述多肽片段或突变多肽，以确定哪个部分保留有生物活性。本发明多肽的各个部分和其它变异体也可以通过合成或重组方法产生。使用本领域一般技术人员周知的技术可以产生少于约100个氨基酸通常少于约50个氨基酸的合成多肽。例如，可以使用任何市售的固相技术，如氨基酸连续加入至增长的氨基酸链的Merrifield固相合成法，合成这种多肽。参见Merrifield，J.Am.Chem.Soc.852149-2146，1963。自动合成多肽仪器可从如PerkinElmer/AppliedBioSystems，Inc.(FosterCity，California)的供应商购买，并可按照生产商的说明书操作。可以使用标准诱变技术，如寡核苷酸定点特异性诱变(Kunkel，T.，Proc.Natl.Acad.Sci.USA82488-492，1985)，制备天然多肽变异体。也可以使用允许制备截短多肽的标准技术除去DNA序列的若干部分。一般而言，本文公开的多肽制备成分离的大致纯的形式。所述多肽优选至少约80％纯度，更优选至少约90％纯度，而最优选至少约99％纯度。在下文详述的某些优选实施方案中，将所述分离的多肽加入到用于治疗皮肤病的药用组合物或疫苗中。本文使用的术语“变异体”包括与明确鉴定序列不同的核苷酸或氨基酸序列，其中缺失、取代或添加一个或多个核苷酸或氨基酸残基。变异体可以是天然等位基因变异体或非天然变异体。变异体序列(多核苷酸或多肽)与本发明的序列的同一性优选为至少50％，更优选至少75％，而最优选至少90％。通过如下所述比较对比两个序列，确定对比部分的相同残基数目，将该数除以本发明(查询)序列的残基总数，并将结果乘以100，可测得同一性百分率。可以对多核苷酸或多肽序列进行序列对比，并可使用可公开得到的计算机算法测定具体区域相对于另一种多核苷酸或多肽的同一性百分率。两种对比和鉴定多核苷酸序列相似性的典型算法是BLASTN算法和FASTA算法。可以使用BLASTP和FASTP算法检测多肽序列的对比和相似性。BLASTX和FASTX算法比较全部读框中翻译的核苷酸查询序列与多肽序列。BLASTN、BLASTP和BLASTX算法可以/blast/executables/在NCBI匿名FTP服务器(ftp//ncbi.nlm.nih.gov)上获得。FASTA和FASTX算法可在Internet上的ftp站点ftp//tfp.virginia.edu/pub/获得。可使用FASTA算法确定多核苷酸变异体，该算法设置为文件管理介绍并随该算法配送的默认参数。随所述算法配送的FASTA和FASTX1.0x版的自述文件介绍了算法的使用和默认参数。FASTA和FASTX算法的使用在Pearson，WR和Lipman，DJ，“改进的生物序列分析工具”，PNAS852444-2448，1998；和Pearson，WR，“用FASTP和FASTA快速灵敏地对比序列”，MethodsinEnzymology18363-98，1990中也有介绍。优选使用BLASTN算法2.0.4版[1998年2月24日]确定本发明的多核苷酸变异体，该算法设置为文件管理介绍并随该算法配送的默认参数。优选使用BLASTP算法2.0.4版确定本发明的多肽变异体，该算法设置为文件管理介绍并随该算法配送的默认参数。URL为http//www.ncbi.nlm.nih.gov/BLAST/newblast.html的NCBIWeb站点和出版物Altschul，StephenF.等，“空位BLAST和PSI-BLAST新一代蛋白质数据库检索程序”，NucleicAcidsRes.253389-3402，1997介绍了BLAST算法家族算法(包括BLASTN、BLASTP和BLASTX)的使用。以下工作参数优选用于使用BLASTN测定对比和相似性，得到多核苷酸的E值和同一性百分率Unix运行命令的默认参数如下blastall-pblastn-dembldb-e10-G0-E0-r1-v30-b30-iqueryseq-0results；而参数是-p程序名称[String]；-d数据库[String]；-e预期值(E)[Real]；-G空位开放惩罚(cost)(0调用默认运行)[Integer]；-E空位延长惩罚(0调用默认运行)[Integar]；-r核苷酸匹配奖励(reward)(仅适用于blastn)[Integer]；-v单行描述的数目(V)[Integer]；-b显示的对比数目(B)[Integer]；-i查询文件[FileIn]；-oBLAST报告输出文件[FileOut]任选(Optional)。以下工作参数优选用于使用BLASTP测定对比和相似性，得到多肽的E值和同一性百分率blastall-pblastp-dswissprotdb-e10-Gl-E11-r1-v30-b30-iqueryseq-0results；而参数是-p程序名称[String]；-d数据库[String]；-e预期值(E)[Real]；-G空位开放惩罚(0调用默认运行)[Integer]；-E空位延长惩罚(0调用默认运行)[Integer]；-v单行描述的数目(v)[Integer]；-b显示的对比数目(b)[Integer]；-I查询文件[FileIn]；-oBLAST报告输出文件[FileOut]任选。由BLASTN、BLASTP、FASTA或相似算法获得的查询序列对一个或多个数据库序列的“命中”排列和鉴定序列的相似部分。根据相似度和序列重叠长度整理命中情况。对数据库序列的命中通常代表仅在查询序列的一部分序列长度上重叠。如下确定多核苷酸或多肽序列的相似性百分率分别使用设定为默认参数的合适算法，例如BLASTN或BLASTP，对比多核苷酸和多肽序列；鉴定对比部分相同的核酸或氨基酸数目；将相同的核酸或氨基酸数目除以本发明的多核苷酸或多肽的核酸或氨基酸的总数；然后再乘以100，得出相似性百分率。举例来说，在使用默认参数的BLSATN算法进行的对比中，具有220个核酸的查询多核苷酸在520个核酸的EMBL数据库中在23个核苷酸的序列段上命中了多核苷酸序列。命中的23个核苷酸包括21个相同的核苷酸、一个空位和一个不同核苷酸。因此，查询多核苷酸对EMBL数据库中的命中核苷酸的同一性百分率为21/220乘以100，或为9.5％。多肽序列相似性可以相似的方式确定。BLASTN和BLASTX算法还产生多核苷酸和多肽序列对比的“预期”值。预期值(E)表示在检索一定大小的数据库时，对于一定数目的连续序列，人们可“预期”偶然命中数。预期值用作测定对数据库的命中是否为真实相似性的显著性阈值。例如，一个多核苷酸命中测得的E值为0.1，其含义可解释为在一个EMBL数据库大小的数据库中，对于具有相似得分(score)的序列的对比部分，人们可以预期简单偶然匹配为0.1个。按此标准，序列的对比和匹配部分相同的可能性为90％。对于对比和匹配部分E值为0.01或0.01以下的序列，使用BLASTN算法在EMBL数据库中偶然发现匹配的可能性为1％或更小。使用各种多肽数据库，诸如SwissProt数据库，以相似的方式可测定多肽序列的E值。按照一个实施方案，相对于本发明的每个多核苷酸和多肽，“变异”多核苷酸和多肽最好含有这样的序列与本发明的多核苷酸和多肽相比，含有的核酸或氨基酸数目与本发明的多核苷酸和多肽相同或略少，并且产生的E值为0.01或0.01以下。即变异体多核苷酸或多肽是任何以下序列与本发明的多核苷酸和多肽相同的可能性至少为99％，使用设定为默认参数的BLASTN或BLASTX算法检测到其E值为0.01或0.01以下。按照一个优选实施方案，变异体多核苷酸是其核酸数目与本发明的多核苷酸相同或略少的序列，它与本发明的多核苷酸相同的可能性至少为99％，使用设定为默认参数的BLASTN算法检测到其E值为0.01或0.01以下。同样，按照一个优选实施方案，变异体多肽是其氨基酸数目与本发明的多肽相同或略少的序列，它与本发明的多肽相同的可能性至少为99％，使用设定为默认参数的BLASTP算法检测到其E值为0.01或0.01以下。变异体多核苷酸序列通常在严格条件下与所述多核苷酸序列杂交。本文使用的“严格条件”是指在6XSSC、0.2％SDS溶液中预清洗；在65℃、6XSSC、0.2％SDS下杂交过夜；然后在1XSSC、0.1％SDS中于65℃清洗两次，每次30分钟，并在0.2XSSC、0.1％SDS中于65℃清洗两次，每次30分钟。本文使用的以“x”具体值为基准的术语“x聚体”是指至少包含以下任何一种多核苷酸或多肽的特定数目(“x”)连续残基的多核苷酸或多肽SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464提供的多核苷酸；SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465多肽。根据具体序列x值可以为约20至约600。本发明的多核苷酸包括至少含下述任何一种多核苷酸或其变异体的特定数目连续残基(x-聚体)的多核苷酸SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464多核苷酸。本发明的多肽包括至少含下述任何一种多肽的特定数目连续残基(x-聚体)的多肽SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465多肽。按照优选实施方案，x值至少20，更优选至少40，再更优选至少60，最优选至少80。因此，本发明的多核苷酸包括含SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464提供的多核苷酸或其变异体的20聚体、40聚体、60聚体、80聚体、100聚体、120聚体、150聚体、180聚体、220聚体、250聚体的多核苷酸；或300聚体、400聚体、500聚体或600聚体的多核苷酸。本发明的多肽包括含SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的多肽或其变异体的20聚体、40聚体、60聚体、80聚体、100聚体、120聚体、150聚体、180聚体、220聚体、250聚体的多肽；或300聚体、400聚体、500聚体或600聚体的多肽。可以如以下实施例1所述，通过对哺乳动物皮肤细胞制备的cDNA文库进行高通量测序，分离本发明的多核苷酸。或者，可以合成基于SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464所提供序列的寡核苷酸探针，并用于利用杂交或聚合酶链反应(PCR)技术鉴定哺乳动物皮肤细胞cDNA文库或基因组DNA文库中的阳性克隆。探针的长度可以短于本文提供的序列，但应当至少约10个核苷酸长，优选至少约15个核苷酸长，而最优选至少约20个核苷酸长。适用于所述寡核苷酸探针的杂交和PCR技术是本领域众所周知的(参见例如Mullis等，ColdSpringHarborSymp.QuantBiol.，51263，1987；Erlich等，PCRTechnology，StocktonPressNY，1989；(Sambrook，J，Fritsch，EF和Maniatis，T编著的MolecularCloningALaboratoryManual，第二版，ColdSpringHarborLaboratoryPress，ColdSpringHarborNewYork，1989)。可以通过限制酶消化、DNA测序等方法分析阳性克隆。另外，可以通过使用本领域熟知技术的合成方法产生本发明的DNA序列。自动合成寡核苷酸的设备可从诸如PerkinElmer/AppliedBiosystemsDivision(FosterCity，California)的供应商处购得，并可按照生产商的说明书操作。因为本发明的多核苷酸序列得自皮肤，所以它们可能编码在皮肤生长发育以及皮肤对组织损伤和炎症以及各种疾病状态反应中起重要作用的蛋白。某些多核苷酸包含编码信号序列或跨膜结构域的序列，它们使蛋白产物鉴定为分泌分子或受体。这样的蛋白产物可能是生长因子、细胞因子或其关连受体。几个多肽序列与已知的生物重要蛋白的相似性超过25％，并因此可能为具有相似生物功能的蛋白。具体来说，本发明多肽在诸如以下的过程中起重要作用诱导毛发生长；使皮肤干细胞分化为特化细胞类型；细胞迁移；细胞增殖和细胞-细胞相互作用。所述多肽对于保持组织完整性很重要，因此在诸如伤口愈合的过程中起重要作用。某些公开多肽在免疫应答中起调节剂作用，尤其是在知道免疫细胞在组织损伤过程中浸润皮肤，引起皮肤细胞生长分化以后。此外，许多多肽具有免疫活性，这使它们在所有疾病状态(不但是皮肤，而且包括机体的其它组织)中成为重要的治疗标靶。抗本发明多肽的抗体和涉及本发明多肽的小分子抑制剂还可以按照本发明用于调节免疫应答和治疗疾病。一方面，本发明提供使用一种或多种本发明多肽或多核苷酸治疗患者疾病的方法。本文使用的“患者”是指任何恒温动物，优选人类。在此方面，所述多肽或多核苷酸一般存在于药用组合物或疫苗中。药用组合物可以包含一种或多种多肽，其中每一种都可以包含一个或多个上述序列(或其变异体)以及生理学上可接受的载体。疫苗可以包含一种或多种上述多肽和非特异性免疫应答增强剂，诸如所述多肽搀入到其中的佐剂或脂质体。另一方面，本发明的疫苗或药用组合物可以含有编码一种或多种上述多肽的DNA，使得所述多肽可原位产生。在这样的疫苗和药用组合物中，所述DNA可以存在于本领域一般技术人员已知的各种传递系统中的任一种中，包括核酸表达系统以及细菌和病毒表达系统。合适的核酸表达系统包含在患者体内表达的必需DNA序列(诸如合适的启动子信号和终止子信号)。细菌传递系统包括给予在其细胞表面表达所述多肽的免疫原性部分的细菌(诸如Bacillus-Calmette-Guerin)。在一个优选实施方案中，可以使用病毒表达系统(例如痘苗病毒或其它痘病毒、反转录病毒或腺病毒)引入所述DNA，病毒表达系统可能涉及使用非致病性病毒或缺陷型可复制病毒。将DNA加入到所述表达系统中的技术是本领域众所周知的。所述DNA还可以是“裸”DNA，见例如Ulmer等，Science2591745-1749，1993介绍和Cohen，Science2591691-1692，1993的综述。可以通过将所述DNA包被在有效转运至细胞中的生物降解珠上，增加裸DNA的吸收。给予途径和频率以及给予剂量各个体之间不同。一般而言，所述药用组合物和疫苗可以通过注射(例如皮内、肌内、静脉内或皮下)、鼻内(例如吸入)和口服给予。一般来说，一剂中的多肽量(或一剂所述DNA原位产生的多肽量)为每kg宿主体重约1pg-约100mg，通常为每kg宿主体重约10pg-约1mg，优选为每kg宿主体重约100pg-约1μg。合适的剂量范围将根据所述患者大小而有所变化，但通常为约0.1ml-约5ml。尽管可以在本发明的药用组合物中使用本领域一般技术人员已知的任一合适载体，但载体的类型将根据给予方式而有所变化。对于胃肠外给予，诸如皮下注射，所述载体优选包括水、盐水、醇、脂质、蜡或缓冲液。对于口服给予，可以使用以上载体中的任一种或固体载体，如甘露醇、乳糖、淀粉、硬脂酸镁、糖精钠、滑石粉、纤维素、葡萄糖、蔗糖和碳酸镁。还可以使用生物降解微球(例如聚乳酸半乳糖苷(galactide))作为本发明药用组合物的载体。合适的生物降解微球公开于例如美国专利第4,897,268和5,075,109号。在本发明的疫苗中可以使用各种佐剂中的任一种，以非特异性增强免疫应答。大多数佐剂包含设计用来保护抗原免受快速分解代谢的物质(诸如氢氧化铝或矿物油)和免疫应答的非特异性刺激剂(诸如类脂A、百日咳杆菌(Bordetellapertussis)或结核分支杆菌(M.tuberculosis))。合适的佐剂可市售获得，如弗氏不完全佐剂和弗氏完全佐剂(DifcoLaboratories，Detroit，Michigan)，以及Merck佐剂65(MerckandCompany，Inc.，Rahway，NewJersey)。其它合适的佐剂包括明矾、生物降解微球、单磷酰脂质A和QuilA。本发明的多核苷酸还可在遗传疾病的鉴定中用作组织标记、用作染色体标志或标记，以及用于设计寡核苷酸，以使用本领域周知技术(诸如Synteni(PaloAlto，California)提供的微阵列技术)检测表达模式。通过例如使用基于本发明序列的杂交探针或PCR引物筛选DNA表达文库，可利用本文公开的部分多核苷酸序列获得全长基因。另外，本发明提供的多核苷酸可用在检测生物活性、产生抗体、分离相应的配体或受体的测定中，用在定量检测作为抗炎药物的蛋白或相关对应配体或受体水平的测定中，以及用在用于皮肤、结缔组织和/或神经组织生长或再生的组合物中。实施例1从皮肤细胞表达文库中分离cDNA序列通过对构建自表1所示的特化啮齿类或人类皮肤细胞的cDNA表达文库进行高通量测序，获得本发明的cDNA序列。表1文库皮肤细胞类型来源DEPA真皮乳头大鼠SKTC角质细胞人HNFF新生儿包皮成纤维细胞人MEMS胚胎皮肤小鼠KSCL角质形成细胞干细胞小鼠TRAM移行放大细胞小鼠如下所述制备这些cDNA文库。真皮乳头的cDNA文库(DEPA)使得自大鼠触须(腮须)的真皮乳头细胞在培养基中生长，并使用确立的方案由这些细胞提取总RNA。采用Poly(A)QuikmRNA分离试剂盒(Stratagene，LaJolla，California)，按照生产商的说明书，用利用TRIzol试剂(BRLLifeTechnologies，Gaithersburg，Maryland)分离的总RNA获得mRNA。然后通过使用λZAPcDNA文库合成试剂盒(Stratagene)经反转录合成由所述mRNA制备cDNA表达文库。角质细胞的cDNA文库(SKTC)使得自人类新生儿包皮的角质细胞(Mitra，R和Nikoloff，B，载于HandbookofKeratinocyteMethods，第17-24页，1994)在无血清KSFM(BRLLifeTechnologies)中生长，并与分化细胞(108细胞)一起收获。通过以10％的终浓度向培养基中加入胎牛血清使角质细胞分化，并在48小时后收获细胞。用TRIzol试剂(BRLLifeTechnologies)从两个细胞群中分离总RNA，并采用Poly(A)QuikmRNA分离试剂盒(Stratagene)由总RNA中获得mRNA。使用PCR-选择cDNA扣除试剂盒(Clontech，PaloAlto，California)富集分化角质细胞表达的cDNA。简而言之，由未分化角质细胞(“驱动者mRNA(drivermRNA)”)或分化角质细胞(“测试者mRNA(testermRNA)”)中获得mRNA，并用于合成cDNA。用RsaI分别消化两个cDNA群获得较短的平端分子。通过在所述cDNA末端连接不同的接头产生两个测试者群，用过量驱动者cDNA进行两轮连续杂交。所述接头只允许分化表达序列进行PCR扩增，然后所述序列连接入T-tailedpBluescript(Hadjeb，N和Berkowitz，GA，BioTechniques2020-221996)中，使得可对包含具有插入片段的载体的细胞进行蓝/白选择。分离白色细胞并利用其获得用于测序的质粒DNA。人类新生儿成纤维细胞的cDNA文库(HNFF)在培养基中培养得自人类新生儿包皮移植物的成纤维细胞，并使用确立的方案由这些细胞中提取总RNA。使用Poly(A)QuikmRNA分离试剂盒(Stratagene，LaJolla，California)并按照生产商的说明书由用TRIzol试剂(BRLLifeTechnologies，Gaithersburg，Maryland)分离的总RNA获得mRNA。然后使用λZAPcDNA文库合成试剂盒(Stratagene)由所述mRNA经反转录酶合成制备cDNA表达文库。小鼠胚胎皮肤的cDNA文库(MEMS)显微解剖交配后13天的Balb/c小鼠胚胎皮肤。在磷酸缓冲盐水中清洗胚胎皮肤，并利用QuickPrepMicromRNA纯化试剂盒(Pharmacia，Sweden)直接分离小鼠胚胎皮肤mRNA。然后使用mRNA按照以上DEPA文库制备所述制备cDNA文库。小鼠干细胞(KSCL)和移行放大(TRAM)细胞的cDNA文库从产后1-2天的新生Balb/c小鼠获取毛皮，清洗并在胰蛋白酶(BRLLifeTechnologies)中温育，以分离表皮和真皮。破坏表皮组织以分散细胞，然后在生长培养基中重悬浮，并在按照生产商(Pharmacia，Sweden)的方案制备的Percoll密度梯度上离心。使用罗丹明123(BertoncelloI，HodgsonGS和BradleyTR，ExpHematol，13999-1006，1985)标记沉淀细胞，用流式细胞仪(EpicsEliteCoulterCytometry，Hialeah，Florida)进行分析。然后用交叉反应抗大鼠CD29生物素单克隆抗体(Pharmingen，SanDiego，California；克隆Ha2/5)标记罗丹明标记的小鼠角质细胞的单细胞悬浮液。清洗细胞并与结合抗小鼠CD45藻红蛋白的单克隆抗体(Pharmingen；克隆30F11.1，10μg/ml)温育，然后用链霉抗生物素光谱红(SouthernBiotechnology，Birmingham，Alabama)标记。使用表格型(listmode)数据定义分选门(sortgate)，鉴定了4个细胞群CD29明亮罗丹明灰暗CD45阴性细胞；CD29明亮罗丹明明亮CD45阴性细胞；CD29灰暗罗丹明明亮CD45阴性细胞；和CD29灰暗罗丹明灰暗CD45阴性细胞。分离、沉淀细胞，快速冷冻后储存在-80℃。此方案实施多次，以获得每种细胞群的足够制备cDNA文库的细胞数。已知皮肤干细胞和移行放大细胞表达CD29—整联蛋白β1链。白细胞特异性抗原CD45在分离皮肤干细胞和移行放大细胞时用作排除细胞的标记。角质细胞干细胞比移行放大细胞更有效地排出罗丹明染料。分选CD29明亮罗丹明灰暗的CD45阴性细胞群(推定为角质细胞干细胞；称为KSCL)和CD29明亮罗丹明明亮的CD45阴性细胞群(角质细胞移行放大细胞，称为TRAM)，使用QuickPrepMicromRNA纯化试剂盒(Pharmacia，Sweden)由每个细胞群直接分离mRNA。然后使用所述mRNA按照以上DEPA文库的描述制备cDNA文库。使用PerkinElmer/AppliedBiosystemsDivisionPrism377测序仪对上述cDNA文库进行高通量测序，获得cDNA序列。实施例2分离cDNA序列的特征使用计算机算法FASTA和/或BLASTN比较分离的cDNA序列和EMBLDNA数据库序列。使用计算机算法FASTX和/或BLASTP比较对应的推测蛋白序列(6个读框中的每一个读框的DNA都被翻译成蛋白)和SwissProt数据库序列。1998年3月21日对SEQIDNO1-119提供的DNA序列与EMBLDNA数据库序列进行对比(使用FASTA)，以及SEQIDNO120-197提供的氨基酸序列与SwissProt数据库序列进行对比(使用FASTX)。1998年10月7日对SEQIDNO198-274提供的DNA序列与EMBLDNA数据库序列进行对比(使用BLASTN)，以及SEQIDNO275-348提供的氨基酸序列与SwissProt数据库序列进行对比(使用BLASTP)。1999年1月23日对SEQIDNO349-372提供的DNA序列与EMBLDNA数据库序列进行对比(使用BLASTN)，以及SEQIDNO373-398提供的氨基酸序列与SwissProt数据库序列进行对比(使用BLASTP)。2000年4月23日对SEQIDNO418-455提供的多核苷酸序列与EMBLDNA数据库序列进行对比(使用BLASTN)，以及SEQIDNO456-463提供的多肽序列与SwissProt数据库序列进行对比(使用BLASTP)。用计算机分析分离的cDNA序列及其对应的推测蛋白序列中存在的鉴定分泌分子的信号序列。SEQIDNO1-44、198-238、349-358、399、418-434和440-449提供在序列推测起始位点具有信号序列的分离cDNA序列。使用上述FASTA或BLASTN计算机算法测定SEQIDNO1-6、198-199、349-352、354、356-358和440的cDNA序列与EMBL数据库序列的同一性小于75％(如上所述测定)。使用上述FASTX或BLASTP计算机算法测定SEQIDNO120-125、275-276、373-380和382的推测氨基酸序列与SwissProt数据库序列的同一性小于75％(如上所述测定)。对某些分离的部分cDNA序列的进一步测序使得分离了SEQIDNO7-14、200-231、372、418-422、441-448的全长cDNA序列。分别以SEQIDNO126-133、277-308和396提供由SEQIDNO7-14、200-231和372的cDNA序列编码的氨基酸序列。SEQIDNO418-422的cDNA序列与SEQIDNO7和11-14的cDNA序列编码相同的氨基酸序列，分别为SEQIDNO126和130-133。使用上述计算机算法FASTA或BLASTN比较所述全长cDNA序列和EMBL数据库序列，结果显示与已知序列的同一性小于75％(如上所述测定)。使用上述计算机算法FASTX或BLASTP比较SEQIDNO126-133和277-308提供的氨基酸序列与SwissProt数据库序列，结果显示与已知序列的同一性小于75％(如上所述测定)。使用计算机算法FASTA数据库比较对应于SEQIDNO15-23的cDNA序列的推测氨基酸序列和EMBL数据库序列，结果显示与已知序列的同一性小于75％(如上所述测定)。SEQIDNO134-142提供这些推测的氨基酸序列。对某些分离的部分cDNA序列的进一步测序使得分离出SEQIDNO24-44、232-238、423-434和449全长cDNA序列。分别以SEQIDNO143-163、309-315和456提供由SEQIDNO24-44、232-238和429的cDNA序列编码的氨基酸序列。SEQIDNO423-428、430-434和449的cDNA序列与SEQIDNO27-29、34、35、37、40-44和238的cDNA序列编码相同的氨基酸序列，分别为SEQIDNO146-148、153、154、156、159-163和315。如上所述使用计算机算法FASTX测定这些氨基酸序列与SwissProt数据库已知序列的同一性小于75％。对与已知表达序列标志(EST)或公共数据库中的其它DNA序列的同一性小于75％的分离cDNA序列，或其对应的与已知蛋白序列的同一性小于75％的推测蛋白序列，用计算机分析其存在的编码推定膜结合分子的跨膜结构域。SEQIDNO45-63、239-253、359-364、400-402、435、436、450-452和455提供在序列中具有一个或多个跨膜结构域的分离cDNA序列。使用FASTA或BLASTN计算机算法发现SEQIDNO45-48、239-249、359-361、363、450、451和455的cDNA序列与EMBL数据库序列的同一性小于75％(如上所述测定)。使用FASTX或BLASTP数据库发现由SEQIDNO45-48、239-249、359-361、363、450和451的cDNA序列编码的氨基酸序列(分别以SEQIDNO164-167、316-326、383、385-388、407-408、460和461提供)与SwissProt数据库序列的同一性小于75％(如上所述测定)。SEQIDNO455的cDNA序列与SEQIDNO359的cDNA序列编码相同的氨基酸序列，即SEQIDNO383。比较对应于SEQIDNO49-63、250-253、436和452cDNA序列的氨基酸序列与SwissProt数据库序列，结果显示与已知序列的同一性小于75％(如上所述测定)。分别以SEQIDNO168-182、327-330、457和462提供这些推测氨基酸序列。使用自动化检索程序筛选编码据报道具有治疗和/或诊断用途的分子的序列，测定如以上实施例1所述分离的某些cDNA序列，其编码的推断蛋白序列似乎是已知蛋白家族成员。在本文中家族成员定义为翻译多肽与蛋白家族的已知蛋白或成员的同一性至少为25％。SEQIDNO64-76、254-264、365-369、403、437-439、453和454提供这些cDNA序列。分别以SEQIDNO183-195、331-341、389-393、409、458、459和463提供由SEQIDNO64-76、254-264、365-369、403、438、439和453的cDNA序列编码的氨基酸序列。SEQIDNO437和454的cDNA序列与SEQIDNO68和262的cDNA序列编码相同的氨基酸序列，分别为SEQIDNO187和339。使用FASTA或BLASTN计算机算法显示SEQIDNO64-68、254-264、365-369、453和454的cDNA序列与EMBL数据库序列的同一性小于75％(如上所述测定)。同样，显示SEQIDNO183-195、331-341、389-393、458、459和463的氨基酸序列与SwissProt数据库序列的同一性小于75％。根据与已知蛋白的相似性，以下提供由SEQIDNO64-76、254-264、365-369、403、438、439、453和454的DNA序列编码的各蛋白功用。表2新型蛋白的功能因此，这些分离序列编码影响几种细胞类型的生长、分化和活化的蛋白。通常可以将它们开发成治疗和诊断皮肤损伤、癌症、生长发育缺陷以及炎症性疾病的药物。SEQIDNO77-117、265-267和404-405的多核苷酸序列在角质细胞干细胞(KSCN)或移行放大细胞(TRAM)中差异表达，其根据是这些序列独自出现在以上两个文库任一个中的次数；在一个文库中超过9次，而在另一个文库中没有(AudicS.和ClaverieJ-M，GenomeResearch，7986-995，1997)。使用上述计算机算法FASTA或BLASTN测定，SEQIDNO77-89、265-267和365-369的序列与EMBL和SwissProt数据库序列的同一性小于75％。这些多核苷酸序列编码的蛋白用作鉴定和分离这些细胞类型的标志，而抗这些蛋白的抗体可有效用于从细胞的复杂混合物中分离和富集这些细胞。干细胞群独有的分离多核苷酸及其相应蛋白可用作药物靶，以改变对皮肤细胞生长和分化的调节，或用于基因打靶以将特异性治疗分子转运至皮肤干细胞。实施例3分离和表征muTR1的人类同源物如以上实施例1所述获得muTR1(SEQIDNO68)的人同源物，通过筛选50,000pfu寡脱氧胸苷引导的Hela细胞cDNA文库进行分离。使用标准分子生物学技术(Sambrook，J，Fritsch，EF和Maniatis，T编著，MolecularCloningALaboratoryManual，第二版，ColdSpringHarborLaboratoryPress，ColdSpringHarborNewYork，1989)进行噬菌斑转移、杂交和筛选。SEQIDNO118提供测定的分离人同源物(huTR1)cDNA序列，SEQIDNO196提供对应的推测氨基酸序列。使用对应于SEQIDNO118编码区的核苷酸1-459的[α32P]-dCTP标记的双链cDNA探针筛选所述文库。huTR1多核苷酸序列具有类似于转化生长因子-α的区，表明该蛋白功能类似于表皮生长因子(EGF)。此EGF样蛋白用于刺激角质细胞生长和迁移以及抑制上皮性癌细胞生长。因此这种新基因及其编码蛋白可用作治疗创伤的药物和上皮性癌细胞的调节剂。应用RNA印迹分析RNA转录物通过用包含SEQIDNO118的核苷酸96-273并用[α32P]-dCTP放射性标记的探针探测人组织mRNA印迹(Clontech)，进行RNA分析，以测定huTR1mRNA的大小和分布。如Sambrook等(同上)所述进行预杂交、杂交、清洗和探针标记。huTR1mRNA的大小为3.5-4kb，观察到其在心脏和胎盘中最丰富，而在脾、胸腺、前列腺和卵巢中观测到的表达水平较低(图1)。huTR1mRNA在心脏和胎盘中的高丰度表明huTR1在血管形成或保持中起作用，因为与机体的其它组织相比心脏和胎盘组织的血管丰度增加，因此内皮细胞丰度也增加。这再次证明huTR1在肿瘤血管发生和血管形成方面的作用。其支持依据是转化生长因子-α和EGF能够诱导血管重产生(Schreiber等，Science2321250-1253，1986)并刺激内皮细胞合成DNA(Schreiber等，Science2321250-1253，1986)及其在各种人类肿瘤中的过量表达。纯化muTR1和huTR1将编码muTR1氨基酸53-103(SEQIDNO342)的muTR1多核苷酸177-329(SEQIDNO268)以及编码huTR1的氨基酸54-104(SEQIDNO343)的huTR1多核苷酸208-360(SEQIDNO269)克隆入细菌表达载体pProEXHT(BRLLifeTechnologies)，该载体含有一个细菌前导序列和N末端6×组氨酸标记。按照Sambrook等所述(同上)将这些构建物转化入感受态XL1-Blue大肠杆菌中。在包含100μg/ml氨苄青霉素的Terrific肉汤培养基中于37℃过夜培养这些重组XL1-Blue大肠杆菌的引子培养物。使培养物旋转减慢并将其接种到500ml包含100μg/ml氨苄青霉素的Terrific肉汤培养基。培养物生长至细胞OD595达到0.4至0.8之间，然后加入IPTG至1mM。过夜诱导所述细胞，离心收集细菌。muTR1多肽(SEQIDNO342，称为muTR1a)和huTR1多肽(SEQIDNO343，称为huTR1a)二者都表达在不溶性包涵体中。为了纯化muTR1a多肽和huTR1a多肽，在裂解缓冲液(20mMTris-HClpH8.0，10mMβ巯基乙醇，1mMPMSF)中重悬浮细菌细胞沉淀。向裂解细胞中加入1％NP40，并在冰上温育所述混合物10分钟。进一步在冰上以95W、4×15秒超声波破碎裂解物，然后以14,000rpm离心15分钟沉淀包涵体。获得的沉淀物在包含0.5％CHAPS(w/v)的裂解缓冲液中重悬浮，在冰上超声5-10秒。将该混合物储存在冰上1小时，以14,000rpm于4℃离心15分钟，弃去上清液。如前所述，使沉淀物再次重悬浮在包含0.5％CHAPS(w/v)的裂解缓冲液中、超声、离心和去除上清液。沉淀物在增溶缓冲液(6M盐酸胍、0.5MNaCl、20mMTrisHCl、pH8.0)中重悬浮，以95W、4×15秒超声处理，然后以14,000rpm于4℃离心20分钟以除去碎片。上清液在用前储存于4℃。使用镍螯合琼脂糖凝胶柱(AmershamPharmacia，Uppsala，Sweden)并按照生产商推荐的方法，利用包含在细菌前导序列中的N末端6×组氨酸标记纯化muTR1a和huTR1a多肽。为了重折叠纯化后的蛋白，在1小时内于4℃将所述蛋白溶液加入至其5倍体积的重折叠缓冲液(1mMEDTA、1.25mM还原谷胱甘肽、0.25mM氧化谷胱甘肽、20mMTris-HCl，pH8.0)中。在这段时间内快速搅拌重折叠缓冲液，并且于4℃持续搅拌过夜。然后使用标准方法经超滤浓缩重折叠蛋白。muTR1a和huTR1a多肽的生物活性muTR1和huTR1是EGF家族(包括EGF、TGFα、epiregulin等)的新成员。已知这些生长因子起EGF受体配体的作用。EGF受体激活途径有许多文献资料证明。配体与EGF受体一旦结合，则发生一连串事件，包括已知为MAP激酶的蛋白的磷酸化。因此MAP激酶磷酸化可用作EGF受体激活的标记。存在识别2种MAP激酶蛋白-ERK1和ERK2磷酸化形式的单克隆抗体。为了检测纯化的muTR1a和huTR1a多肽是否起EGF受体配体的作用，将人表皮癌细胞系A431(美国典型培养物保藏中心，No.CRL-1555，Manassas，Virginia)细胞接种到6孔培养板中，血清饥饿24小时，然后在无血清条件下用纯化的muTR1a或huTR1a刺激5分钟。作为阳性对照，以相同的方式用10-100ng/ml的TGF-α或EGF刺激细胞。作为阴性对照，用包含不同量LPS的PBS刺激细胞。立即裂解细胞，用Bradford测定法检测裂解液蛋白浓度。将15μg各样品蛋白加样于12％SDS-PAGE凝胶。然后使用标准技术将所述蛋白转移至PVDF膜。对于蛋白质印迹，在封闭缓冲液(10mMTris-HCl、pH7.6，100mMNaCl，0.1％Tween-20，5％脱脂奶)中于室温温育膜1小时。在封闭缓冲液中加入兔抗活性MAP激酶pAb(Promega，Madison，Wisconsin)至50ng/ml，并于4℃温育过夜。在无脱脂奶的封闭缓冲液中清洗膜30分钟，然后在室温下与在封闭缓冲液中稀释3500倍的抗兔IgG-HRP抗体温育1小时。在无脱脂奶的封闭缓冲液中清洗膜30分钟，然后在无脱脂奶和0.1％Tween-20的封闭缓冲液中再清洗5分钟。然后把膜在ECL试剂中暴露2分钟，接着放射自显影5-30分钟。如图2所示，发现muTR1a和huTR1a二者均相对于本底水平诱导ERK1和ERK2磷酸化，这表明muTR1和huTR1起细胞表面受体配体的作用，激活MAP激酶信号转导途径，可能是EGF受体。如图11所示，还证实与阴性对照相比，huTR1a诱导培养CV1/EBNA肾上皮细胞的ERK1和ERK2磷酸化。如上所述进行这些测定。表明huTR1a起细胞表面受体配体的作用，激活MAP激酶信号转导途径，可能是HeLa和CV1/EBNA细胞的EGF受体。如下测定muTR1a刺激新生儿阴茎包皮(NE)角质细胞生长的能力。在补加牛垂体提取物(BPE)和表皮生长因子(EGF)的KSFM(BRLLifeTechnologies)中培养取自外科手术废弃物的NF角质细胞。在96孔平底板中于0.1ml未补加的KSFM中进行测定。将MuTR1a、人转化生长因子α(huTGFα)或PBS-BSA滴定至板中，并向每孔中加入1×103NF角质细胞。在5％CO2气氛下于37℃温育所述板5天。如前所述(J.Imm.Meth.93157-165，1986)通过MTT染料还原测定细胞生长的程度。如图3所示，muTR1a和阳性对照人TGFα二者都刺激NF角质细胞生长，而阴性对照PBS-BSA没有此作用。如下测定muTR1a和huTR1a刺激转化人角质细胞系HaCaT生长的能力。在96孔平底板中于0.1ml补加0.2％FCS的DMEM(BRLLifeTechnologies)中进行测定。将muTR1a、huTR1a和PBS-BSA滴定至板中，并向每孔中加入1×103HaCaT细胞。在含10％CO2的大气中于37℃温育所述板5天。如前所述(J.Imm.Meth.93157-165，1986)通过MTT染料还原测定细胞生长的程度。如图4所示，muTR1a和huTR1a二者都刺激HaCaT细胞生长，而阴性对照PBS-BSA没有此作用。如下测定muTR1a和huTR1a抑制A431细胞生长的能力。如前所述(J.Cell.Biol.931-4，1982)滴定多肽MuTR1a(SEQIDNO342)和huTR1a(SEQIDNO343)以及PBS-BSA，并如前所述(J.Imm.Meth.93157-165，1986)用MTT染料还原测定细胞死亡。发现muTR1a和huTR1a二者都抑制A431细胞的生长，而阴性对照PBS-BSA不能(图5)。这些结果表明muTR1和huTR1刺激角质细胞生长和迁移、抑制上皮性癌细胞的生长，并在肿瘤血管发生和血管形成中起作用。因此该新基因与其编码蛋白可开发成治疗创伤、血管发生的药物和上皮性癌症的调节物。上调huTR1和mRNA表达在10厘米培养皿中以每皿1×106细胞的浓度接种HeLa细胞(人宫颈腺癌)。培养过夜后，去除培养基并更换为包含100ng/ml的muTR1、huTR1、huTGFα或作为阴性对照的PBS的培养基。18小时后，去除培养基并在2mlTRIzol试剂(GibcoBRLLifeTechnologies，Gaithersburg，Maryland)中裂解细胞。按照生产商的说明书分离总RNA。为鉴定cDNA样品的huTR1mRNA水平，在标准PCR反应中使用1μlcDNA。30个循环后，由每个PCR反应取出5μl，在1.5％琼脂糖凝胶上进行分离。通过溴化乙锭染色对条带显色。由图12可见，与用阴性对照PBS刺激的细胞相比，小鼠TR1和人TR1都上调huTR1mRNA水平。而且，TGFα也可以上调huTR1mRNA水平。这些结果表明，TR1能够维持其自身的mRNA表达以及随后的蛋白表达，因此预期其能对高水平细胞因子表达参与疾病病理学的疾病(如牛皮癣)发展起作用。而且，因为TGFα可以上调huTR1表达，所以TR1mRNA的上调对于TGFα的作用模式可能是关键性的。血清效应元件报导基因测定血清效应元件(SRE)是生长调节许多细胞立即早期基因必需的启动子元件。已有研究证实，MAP激酶信号转导途径可调节SRE活性。本实验室开发了两个细胞系，即包含8个SV40启动子上游SRE和荧光素酶报导基因的PC12(大鼠嗜铬细胞瘤-神经瘤)和HaCaT(人转化角质细胞)。在96孔板的每孔中等分5×103细胞，并使它们在其各自的培养基中生长24小时。在5％胎牛血清(FBS)的D-MEM中培养HaCaTSRE细胞，其中在D-MEM中补加2mML-谷氨酸盐(Sigma，St.Louis，Missouri)、1mM丙酮酸钠(BRLLifeTechnologies)、0.77mML-天冬酰胺(Sigma)、0.2mM精氨酸(Sigma)、160mM青霉素G(Sigma)、70mM二氢链霉素(RocheMolecularBiochemicals，Basel，Switzerland)和0.5mg/ml遗传霉素(BRLLifeTechnologies)。在5％胎牛血清的HamF12培养基中培养PC12SRE细胞，其中HamF12培养基补加0.4mg/ml遗传霉素(BRLLifeTechnologies)。然后将培养基改变为0.1％FBS并再温育24小时。然后从1μg/ml起逐步增加TR1刺激细胞。使用单一剂量的100ng/ml碱性成纤维细胞生长因子(R&DSystems，Minneapolis，Minnesota)或10ng/ml的表皮生长因子(BRLLifeTechnologies)作为阳性对照。在存在muTR1或阳性对照的情况下温育细胞6小时，在PBS中清洗两次，并用40μl裂解缓冲液(Promega)裂解细胞。转移10μl至96孔培养板，并利用Victor2荧光计(Wallac)经直接注射将10μl荧光素酶底物(Promega)加入每孔中，震摇所述板并以3×1秒的间隔读取每孔的发光。使用以下方程计算SRE诱导倍数SRE诱导倍数＝激动剂平均相对发光/阴性对照平均相对发光。如图13所示，muTR1激活PC-12(图13A)和HaCaT(图13B)细胞二者的SRE。这表明HaCaT和PC-12细胞能够对muTR1蛋白产生反应并激发反应。在HaCaT细胞的情况下，该反应是一种生长反应。在PC-12细胞的情况下，该反应可以是生长、生长抑制、分化或迁移反应。因此，TR1对于神经细胞发育或其分化为专化神经亚群可能很重要。TR1可能对于神经肿瘤的发生和发展也很重要。EGF受体抑制测定如前所述进行HaCaT生长测定，但是进行了以下改进。在所述培养基中加入EGF和TR1的同时，以62.5ng/ml的浓度加入抗-EGF受体(EGFR)抗体(Promega，Madison，Wisconsin)或阴性对照抗体小鼠IgG(PharMingen，SanDiego，California)。由图14可见，阻断EGFR功能的抗体抑制TR1对HaCaT细胞的促有丝分裂性。这表明EGFR对于TR1促有丝分裂信号传递到HaCaT细胞是至关重要的。TR1可以直接结合EGF受体。TR1也可以结合能够与EGFR异二聚化的EGFR家族任何其它成员(例如ErbB-2、-3和/或-4)。HuTR1的剪接变异体按照相同方法由与huTR1相同的文库分离huTR1变异体。称为huTR1-1的序列(也叫做TR1δ)是huTR1的剪接变异体，由去除氨基酸15-44和87-137的huTR1ORF组成。这些缺失导致缺失了部分信号序列和其后的氨基末端接头序列、EGF基元的第二个半胱氨酸残基之后的残基以及随后的跨膜结构域。然而，半胱氨酸残基147(huTR1ORF编号)可以替代缺失的半胱氨酸并因此可能使二硫桥未受影响。因此，huTR1-1是huTR1的胞内形式。它起huTR1或其它EGF家族成员(包括EGF和TGFα)的激动剂或拮抗剂作用。SEQIDNO412给出了huTR1-1的测定核苷酸序列，而对应的氨基酸序列以SEQIDNO415提供。利用标准方法由HeLa细胞分离的RNA制备cDNA，通过PCR由所述cDNA的第一条链分离huTR1的其它4种剪接变异体。huTR1的这些剪接变异体称为TR1-2(也叫做TR1β)、TR1-3(也叫做TR1γ)、TR1ε和TR1φ。TR1-2由去除氨基酸95-137的huTR1ORF组成。该缺失导致缺失了跨膜结构域。因此TR1-2是huTR1的一种分泌形式，并以等于或高于huTR1的亲合性结合TR1受体，因为EGF结构域保持完整。它起huTR1或其它EGF家族成员(包括EGF和TGFα)的激动剂或拮抗剂作用。SEQIDNO410给出了TR1-2的测定cDNA序列，而SEQIDNO413提供对应的氨基酸序列。TR1-3由去除氨基酸36-44和86-136的huTR1ORF组成。这些缺失导致缺失了部分氨基酸末端接头序列、EGF基元的第二个半胱氨酸之后的残基以及随后的跨膜结构域。然而，半胱氨酸残基147(huTR1ORF编号)可以替代缺失的半胱氨酸并因此可能使二硫桥未受影响。因此，TR1-3也是huTR1的一种分泌形式，并起huTR1或其它EGF家族成员(包括EGF和TGFα)的激动剂或拮抗剂的作用。SEQIDNO411给出了TR1-3的测定cDNA序列，而对应的氨基酸序列为SEQIDNO414。TR1ε由去除氨基酸86-136的huTR1ORF组成。该缺失导致缺失了EGF基元第二个半胱氨酸之后的残基和跨膜结构域。然而，半胱氨酸残基147(huTR1ORF编号)可以替代缺失的半胱氨酸并因此可能使二硫桥未受影响。因此，TR1ε也是huTR1的一种分泌形式，并起huTR1或其它EGF家族成员(包括EGF和TGFα)的激动剂或拮抗剂的作用。SEQIDNO371给出了TR1ε的测定cDNA序列，而对应的推测氨基酸序列由SEQIDNO395提供。TR1φ由去除氨基酸36-44和95-136的huTR1ORF组成。这些缺失导致缺失了部分氨基末端接头序列和跨膜结构域。因此，TR1φ是huTR1的一种分泌形式，并以等于或高于huTR1的亲合性结合TR1受体，因为EGF结构域保持完整。它起huTR1或其它EGF家族成员(包括EGF和TGFα)的激动剂或拮抗剂的作用。SEQIDNO416给出了TR1φ的测定核苷酸序列，而对应的推测氨基酸序列由SEQIDNO417提供。实施例4鉴定、分离和表征DP3使用标准细胞生物学技术分离大鼠真皮乳头和爪垫成纤维细胞，使用得自培养的所述细胞的mRNA通过差异展示RT-PCR(改良自LiangP和PardeeAB，Science257967-071，1992)鉴定叫做DP3的部分cDNA片段。用[α32P]-dCTP标记该双链cDNA，并使用其通过筛选400,000pfu寡脱氧胸苷引导的大鼠真皮乳头cDNA文库鉴定全长DP3克隆。SEQIDNO119提供测定的全长DP3cDNA序列，而对应的氨基酸序列由SEQIDNO197提供。使用标准分子生物学技术进行噬菌斑转移、杂交和筛选。实施例5分离和表征KS1通过RNA印迹分析RNA转录物通过用由muKS1的核苷酸268-499组成、用[α32P]-dCTP放射性标记的探针探测小鼠组织mRNA印迹，进行RNA分析，以测定muKS1(SEQIDNO263)mRNA的大小和分布。如Sambrook等(同上)所述进行预杂交、杂交、清洗和探针标记。muKS1mRNA的大小为1.6kb，并观察到其在大脑、肺或任何肌肉以及心脏中最丰富。还可在下消化道(lowerintestine)、皮肤、骨髓和肾脏中检测到表达。睾丸、脾、肝、胸腺、胃未见可检测信号。muKS1的人类同源物使用muKS1(SEQIDNO263)检索EMBL数据库(Release50，1998年六月更新)，以鉴定人EST同源物。前三个同源物为以下EST登录号AA643952、HS1301003和AA865643。它们285个核苷酸、283个核苷酸和285个核苷酸的同源性分别为92.63％、93.64％和94.035％。翻译时鉴定AA643952和HS1301003中的移码。组合全部三个EST鉴定huKS1(SEQIDNO270)和翻译的多肽SEQIDNO344。对比muKS1和huKS1多肽显示96个氨基酸的同一性为95％。鉴定KSCL009274cDNA序列由未成熟小鼠角质细胞构建直接克隆的cDNA文库，并对其进行高通量测序。命名为KDCL009274克隆的序列数据显示，与大鼠巨噬细胞炎性蛋白-2B(MIP-2B)在72个氨基酸上的同一性为35％，而与其鼠类同源物在72个氨基酸上的同一性为32％。1633bp的插入片段(SEQIDNO464；图15A)包含一个300bp的可读框和202bp的5′非翻译区以及1161bp的3′非翻译区。聚腺苷酸信号AATAAA存在于聚腺苷酸尾上游的19个碱基对。预期成熟多肽(SEQIDNO465)长度为77个氨基酸，包含4个无ELR基序的保守半胱氨酸。根据疏水性情况预测了GLY22和Ser23之间的推定信号肽切割位点。此推定趋化因子与KS1相同。使用BLAST程序对EMBL数据库筛选全长序列，结果显示在核苷酸水平上分别与人EST克隆AA643952、AA865643和HS1301003具有一定的同一性。近来描述的人CXC趋化因子BRAK在蛋白质水平上与KS1具有一定的同一性。图15B对比了KS1(在图15B中叫做KLF-1)、BRAK和其它鼠α-趋化因子。使用Phylip程序确定KS1和其它α-趋化因子家族成员之间的系统发育关系。KS1和BRAK显示与其它α-趋化因子的高度趋异性，这支持在多重对比中显示的较低同源性。muKS1和huKS1的细菌表达和纯化将编码muKS1多肽的氨基酸23-99(SEQIDNO345)的muKS1多核苷酸269-502(SEQIDNO271)以及编码huKS1多肽的氨基酸19-95(SEQIDNO346)的huKS1多核苷酸55-288(SEQIDNO272)克隆入细菌表达载体pET-16b(Novagen，Madison，Wisconsin)，该载体含有一个细菌前导序列和N末端6×组氨酸标记。按照Sambrook等所述(同上)将这些构建物转化入感受态XL1-Blue大肠杆菌中。在包含100μg/ml氨苄青霉素的NZY肉汤培养基(Gibco-BRLLifeTechnologies)中于37℃培养包含SEQIDNO271(muKS1a)和SEQIDNO272(huKS1a)的重组BL21(DE3)大肠杆菌(Novagen)的引子培养物。使培养物旋转减慢，将其接种到800mlNZY肉汤培养基和100μg/ml氨苄青霉素中。培养物生长至细胞OD595达到0.4至0.8之间。用1mMIPTG诱导细菌表达3小时。细菌表达产生约15kDa的muKS1a和huKS1a诱导条带。muKS1a和huKS1a都表达在不溶性包涵体中。为了纯化所述多肽，在裂解缓冲液(20mMTris-HClpH8.0，10mMβ巯基乙醇，1mMPMSF)中重悬浮细菌细胞沉淀。向裂解细胞中加入1％NP-40，并在冰上温育所述混合物10分钟。在冰上以95W、4×15秒超声波进一步破碎裂解物，然后以18,000rpm离心15分钟，以沉淀所述包涵体。在包含0.5％CHAPS(w/v)的裂解缓冲液中重悬浮包含所述包涵体的沉淀，超声5-10秒。将该混合物保存在冰上1小时，以14,000rpm于4℃离心15分钟，并弃去上清液。如前所述，沉淀物再一次在包含0.5％CHAPS(w/v)的裂解缓冲液中重悬浮、超声、离心和去除上清液。沉淀在增溶缓冲液(6M盐酸胍、0.5MNaCl、20mMTrisHCl、pH8.0)中重悬浮，以95W、4×15秒超声处理，并以18,000rpm和4℃离心10分钟以除去碎片。上清液储存于4℃。使用镍螯合琼脂糖凝胶柱(AmershamPharmacia，Uppsala，Sweden)并按照生产商的方法，利用包含在所述细菌前导序列中的N末端6×组氨酸标记纯化muKS1a和huKS1a。蛋白在所述柱上纯化两次，以降低内毒素污染。为了纯化后蛋白重折叠，于4℃将所述蛋白溶液在4M-2M尿素梯度的20mMtris-HClpH7.5+10％甘油溶液中透析过夜。然后将所述蛋白对2升20mMTris-HClpH7.5+10％(w/v)甘油再透析两次。获得的制备物经SDS-PAGE测定，其纯度超过95％。用鲎变形细胞溶解物检测试剂盒(BIOWhittaker，Walkersville，MD)测定纯化蛋白的内毒素污染情况。内毒素水平小于0.1ng/μg蛋白。对KS1胰蛋白酶肽进行内部氨基酸测序。通过在HEK293T细胞中表达产生Fc融合蛋白。用35μgKLF-1plGFcDNA转染每瓶6×106细胞，产生200ml含Fc的上清液。使用AffiprepA蛋白树脂(0.3ml柱，Biorad)通过层析分离所述Fc融合蛋白。上样后，用15mlPBS清洗柱，接着用5ml50mM柠檬酸钠pH5.0清洗。然后用6柱体积的50mM柠檬酸钠pH2.5洗脱蛋白，用含60μl2MTris-HClpH8.0的试管收集0.3ml流分。通过SDS-PAGE分析流分。对muKS1和huKS1的肽测序在聚丙烯酰胺凝胶上分离细菌表达的muKS1和huKS1，并鉴定出15kDa的诱导条带。muKS1的预测大小为9.4kDa。为获得15kDa条带的氨基酸序列，通过SDS-PAGE分离20μg重组muKS1和huKS1，并电印迹在ImmobilonPVDF膜(Millipore，Bedford，Massachusetts)上。由新西兰奥克兰大学的蛋白质测序小组对muKS1和huKS1胰蛋白酶肽进行内部氨基酸测序。SEQIDNO397和398分别给出了muKS1和huKS1的测定氨基酸序列。这些氨基酸序列证实，所述测定序列与由cDNA序列推定的氨基酸序列相同。以前报导了其它趋化因子的大小差异(RichmondA，BalentienE，ThomasHG，FlaggsG，BartonDE，SpiessJ，BordoniR，FranckeU，DerynckR，“结构上与β-血小板球蛋白相关的生长因子的黑素瘤生长刺激活性的分子特征和染色体作图”，EMBOJ.72025-2033，1988；LiaoF，RabinRL，YannelliJR，KoniarisLG，VanguriP，FarberJM，“人Nig趋化因子生物化学和功能特征”，J.Exp.Med.1821301-1314，1995)。使用DNASIS(HITACHISoftwareEngineering，SanFrancisco，California)预测这些蛋白的等电聚焦点为10.26。表达并用A蛋白亲合层析柱纯化的重组Fc标记KS1是一种均一蛋白，分子量为42kDa。氧化爆发测定氧化爆发测定用于测定反应细胞类型。将1×107PBMC细胞重悬浮在5mlHBSS、20mMHEPES、0.5％BSA中，并于37℃和5μl5mM二乙酸二氯-二氢荧光素(H2DCFDA，MolecularProbes，Eugene，Oregon)温育30分钟。将2×105H2DCFDA标记的细胞加样于96孔平底培养板的每个孔中。同时向平底板的孔中加入每种激动剂各10μl，使得最终的浓度为100ng/ml(使用的fMLP为10μM)。然后用Victor21420多标记计数器(Wallac，Turku，Finland)以485nm的激发波长和535nm的发射波长对所述板读数。在60分钟内以5分钟的间隔检测相对荧光。在PBMC中鉴定出明显的呼吸爆发，对照处理细胞(TR1)和100ng/mlmuKS1之间相差2.5倍(图8)。使用人基质衍生因子-1α(SDF1α)(100ng/ml)和10μM甲酰-Met-Leu-Phe(fMLP)作为阳性对照。趋化性测定使用48孔Boyden室(NeuroProbeInc.，CabinJohn，Maryland)按照生产商的方法测试muKS1作用下的细胞迁移。简而言之，在HBSS、20mMHEPES、0.5％BSA中稀释激动剂，并将其加入趋化室的底孔中。在相同的缓冲液中以3×105细胞/50μl重悬浮THP-1细胞。用无PVP聚碳酸酯滤膜分开顶孔和底孔，滤膜孔径为5μm(单核细胞)或3μm(淋巴细胞)。将细胞加入到顶孔，所述室在5％CO2湿润培养箱中于37℃温育2小时(单核细胞)和4小时(淋巴细胞)。温育后，固定滤膜，从上表面刮下细胞。然后用Diff-Quick(DadeInternationalInc.，Miami，Florida)染色滤膜，并在5个随机选择的高倍视野中计数迁移细胞。结果表示为迁移指数(测试迁移细胞数除以对照迁移细胞数)。使用此测定，测试muKS1对T细胞和THP-1细胞的作用。0.01ng/ml至100ng/ml的muKS1对THP-1细胞诱导逐渐增强的趋化作用(图9)。人SDF1α用作阳性对照并获得等同的迁移。还测试了muKS1对IL-2活化T细胞的作用。然而，即使是高浓度的muKS1也没有迁移，而SDF-1α显示明显的逐渐增强的趋化刺激。因此，muKS1于测试的浓度对于THP-1细胞是趋化性的，而对于IL-2活化T细胞不是趋化性的。流式细胞仪结合研究按以下方式测试KLF-1与THP-1和Jurkat细胞的结合。在3ml清洗缓冲液(2％FBS和0.2％叠氮化钠的PBS溶液)中重悬浮THP-1或Jurkat细胞(5×106)，于4℃、200g沉淀5分钟。然后用0.5％小鼠和山羊血清在冰上封闭细胞30分钟。对细胞进行清洗、沉淀、在50μl的10μg/mlKLF-1Fc中重悬浮，并在冰上温育30分钟。温育后，如前所述制备细胞并重悬浮在50μl的10μg/ml山羊抗人IgG生物素(SouthernBiotechnologyAssociates，AL)中，并在冰上温育细胞30分钟。最后，对细胞进行清洗、沉淀和在50μl的10μg/ml链霉抗生物素-RPE(SouthernBiotechnologyAssociates，AL)中重悬浮，并在冰上于黑暗中再温育30分钟。清洗细胞并在250μl清洗缓冲液中重悬浮，用1μl的10μg/ml碘化丙锭(Sigma)染色，以排除任何死亡细胞。纯化的Fc片段(10μg/ml)代替KLF-1Fc用作阴性对照，以测定非特异性结合。在Elite细胞分选器(CoulterCytometry)上使用PE滤片(峰值透光率为575nm，带宽10nm)布置在对数水平上(onlogscale)分析一万个闸门事件。呼吸爆发和迁移测定表明，KS1对单核细胞有活性，而对T细胞没有活性；因此，在与THP-1和Jurkat细胞的结合研究中测试KS1Fc融合蛋白。KS1Fc与单独的Fc片段相比，显示对THP-1细胞明显的正偏移。相反，在相同的实验中KS1显示没有正结合Jurkat细胞。muKS1克隆的全长序列通过测定额外EST的碱基序列扩展muKS1的核苷酸序列。组合所有的EST鉴定全长muKS1(SEQIDNO370)而相应的翻译多肽序列为SEQIDNO394。通过RNA印迹分析人RNA转录物通过用由huKS1核苷酸1-288(SEQIDNO270)组成的放射性标记探针探测人组织印迹(Clontech，PaloAlto，California)，进行RNA印迹分析，以测定muKS1人类同源物mRNA的大小和分布。如Sambrook等所述(同上)进行预杂交、杂交、清洗和探针标记。huKS1mRNA的大小为1.6kb，并观察到其在肾脏、肝脏、结肠、小肠和脾中最丰富。在胰腺、骨骼肌、胎盘、大脑、心脏、前列腺和胸腺中也可检测到表达。在肺、卵巢和睾丸未发现检测信号。通过RNA印迹分析肿瘤组织中的人RNA转录物如前所述通过探测肿瘤格形(panel)印迹(Invitrogen，Carlsbad，California)进行RNA印迹分析，以测定huKS1在癌组织中的分布。这些印迹在正常组织和肿瘤组织之间产生直接对比。在正常的子宫和子宫颈组织观测到mRNA，而在相应的肿瘤组织中没有观测到。相反，表达在乳瘤中被上调，而在正常乳房组织中被下调。在卵巢或卵巢肿瘤中均未发现检测信号。给C3H/HeJ小鼠注射细菌重组muKS1将18只C3H/HeJ小鼠分为3组并腹膜注射muKS1、GV14B或磷酸缓冲盐水(PBS)。GV14B是一种细菌表达的重组蛋白，用作阴性对照。第1组的小鼠注射50μgmuKS1的1mlPBS溶液；第2组小鼠注射50μgGV14B的1mlPBS溶液；而第3组小鼠注射1mlPBS。18小时后，通过用2×4ml收获溶液(0.02％EDTA的PBS溶液)进行腹膜内灌洗分离出小鼠腹膜腔中的细胞。对每组的各只小鼠进行活细胞计数。注射50μgmuKS1小鼠的细胞数量平均升高3倍(图10)。对3只C3H/HeJ小鼠的左后脚皮下注射20μg细菌重组muKS1。在所述小鼠右侧相同部位注射相同体积的PBS。18小时后，检测小鼠的炎症情况。所有注射细菌重组muKS1的小鼠的爪垫都显示红肿。根据组织学，注射muKS1的部位存在单核细胞和多形核细胞混合表型的炎性反应。对裸鼠注射细菌表达的muKS1a为确定炎性反应是否是需要T细胞，使用裸鼠重复所述实验。用75μl在磷酸缓冲盐水中稀释10倍的Hypnorm(JanssenPharmaceuticals，Buckinghamshire，England)腹膜内麻醉2只裸鼠。在左后爪、耳和背部左侧皮下注射20μg细菌表达的muKS1a(SEQIDNO345)。在所述小鼠右侧相同部位注射相同体积的磷酸缓冲盐水。留置小鼠18小时后检测小鼠的炎症。两只小鼠在注射细菌表达蛋白的耳部和爪部都显示红肿。在两个后背部位未能鉴定出明显的炎症。挑选小鼠并由耳部、背部和爪部取活组织检查样品，在3.7％甲醛盐水中固定。对活检组织进行包埋、切片，并用Haemotoxylin和曙红染色。注射muKS1a的部位多形核粒细胞显著增加，而注射磷酸缓冲盐水的部位具有低本底水平的多形核粒细胞浸润。讨论趋化因子是一个功能众多的高度碱性分泌性蛋白的庞大超家族(Baggiolini等，Annu.Rev.Immunol.，15675-705，1997；Ward等，Immunity，91-11，1998；Horuk，Nature，393524-525，1998)。muKS1和huKS1多肽序列与CXC趋化因子具有相似性，表明该蛋白的作用与其它CXC趋化因子类似。裸鼠的体内数据支持此假设。因此可预期此趋化因子样蛋白刺激白细胞、上皮细胞、基质细胞和神经细胞迁移；促进血管发生和血管形成；促进神经元图式发育、造血干细胞转移、角质干细胞和上皮干细胞图式发生和发育、白细胞活化和增殖；并促进伤口愈合过程中的迁移。近来已经证明，趋化因子受体起HIV-1感染CD4+细胞的共受体作用(Cairns等，NatureMedicine，4563-568，1998)，并且高循环水平的趋化因子可以使暴露于HIV病毒的对象一定程度的免疫性(Zagury等，Proc.Natl.Acad.Sci.USA953857-3861，1998)。此新基因与其编码蛋白因此可有效用作上皮细胞、淋巴样细胞、骨髓细胞、基质细胞和神经细胞迁移以及癌症的调节剂；用作治疗癌症、神经退行性疾病、炎症性自身免疫病(如牛皮癣、哮喘和节段性回肠炎)和伤口愈合的药物；以及用作预防HIV-1结合和感染白细胞的药物。此外，我们证明用muKS1注射C3H/HeJ小鼠时，muKS1促进腹膜腔细胞数量可计量性增加。而且，我们证实，muKS1诱导人外周血单核细胞氧化爆发以及诱导人单核细胞白血病细胞系THP-1迁移，说明单核细胞/巨噬细胞是KS1效应细胞类型之一。除此之外，我们证明huKS1在许多非淋巴组织(诸如结肠和小肠)以及乳腺肿瘤中高水平表达。huKS1还在正常子宫和子宫颈组织中表达，但在其相应肿瘤组织中被彻底下调。近来已经显示，非ELR趋化因子表现出制管张素特性。以前已经证实两种非-ELR趋化因子IP-10和Mig在肿瘤消退过程中上调(TannenbaumCS，TubbsR，ArmstrongD，FinkeJH，BukowskiRM，HamiltonTA，“CXC趋化因子IP-10和Mig对IL-12介导的小鼠RENCA肿瘤退化是必不可少的”，J.Immunol.161927-932，1998)，表达水平与肿瘤大小负相关(KaneganeC，SgadariC，KaneganeH，Teruya-FeldstineJ，YaoO，GuptaG，FarberJM，LiaoF，LiuL，TosatoG，“CXC趋化因子IP-10和Mig与IL-12抗肿瘤效应有关”，J.Leuko.Biol.64384-392，1998)。而且，IP-10和Mig的中和抗体将降低抗肿瘤作用，表明这些分子对抗肿瘤作用产生影响。因此，预期在子宫颈和子宫瘤的情况下，KS1应具有相似的特性。数据证明，KS1涉及细胞迁移，表明单核细胞/巨噬细胞是KS1效应细胞类型之一。人表达数据结合体外和体内生物学证明，KS1可能是细胞迁移的有效调节剂，并可作为治疗炎症性疾病(如节段性回肠炎、溃疡性结肠炎和类风湿性关节炎)和癌症(诸如子宫颈腺癌、子宫平滑肌瘤和乳房侵袭性导管癌)的药物。实施例6KS2的特征鉴定KS2包含一个跨膜结构域，并起膜结合配体或受体的作用。RNA分析表明，KS2mRNA在小鼠角质细胞系Pam212中表达，与在小鼠角质细胞中鉴定的cDNA一致。哺乳动物表达为了表达KS2，将胞外结构域与具有C-末端6×组氨酸标记的免疫球蛋白G恒定区(Fc)的氨基末端相融合。这可通过将编码多肽KS2的氨基酸1-215(SEQIDNO347)的KS2多核苷酸20-664(SEQIDNO273)克隆入哺乳动物表达载体pcDNA3(Invitrogen，NVLeek，Netherlands)，并融合至具有C-末端6×组氨酸标记的免疫球蛋白G恒定区(Fc)的氨基末端。如Sambrook等所述(同上)将此构建物转化入感受态XL1-Blue大肠杆菌中。使用DEAE-葡聚糖经用180μgKS1a转染的5×T175培养瓶中的Cos-1细胞而表达KS2a的Fc融合构建物。7天后收获上清液，并使其通过Ni-NTA柱。由该柱洗脱结合的KS2a并对PBS透析。如下测定KS2a的Fc融合多肽抑制IL-2诱导的伴刀豆球蛋白A刺激的小鼠脾细胞生长的能力。由BALA/c小鼠脾制备单细胞悬液，并在补加2mML-谷氨酸盐、1mM丙酮酸钠、0.77mML-天冬酰胺、0.2mML-精氨酸、160mM青霉素G、70mM硫酸二氢链霉素、5×10-2mMβ巯基乙醇和5％FCS的DMEM(Gibco-BRL)(cDMEM)中清洗。用2μg/ml伴刀豆球蛋白A于37℃在10％CO2中刺激脾细胞(4×106/ml)24小时。由培养物收获细胞，在cDMEM中清洗3次，并在补加10ng/mlrhuIL-2的cDMEM中以1×105细胞/ml重悬浮。在96孔圆底板中于0.2mlcDMEM中进行所述测定。将KS2a的Fc融合多肽、PBS、LPS和BSA滴定在所述板中，并向每孔中加入1×104活化T细胞(0.1ml)。在含10％CO2的大气中于37℃温育所述板2天。通过在培养的最后4小时用0.25uCi/ml氚化胸苷脉冲处理所述细胞，此后将细胞收获在玻璃纤维过滤垫上，并利用标准液体闪烁技术测定胸苷掺入程度，从而测定增殖度。如图6所示，发现KS2aFc融合多肽抑制IL-2诱导的伴刀豆球蛋白A刺激的小鼠脾细胞的生长，而阴性对照PBS、BSA和LPS不能。该数据证明，KS2在皮肤角质细胞中表达，并抑制细胞因子诱导的脾细胞的生长。这提示KS2对皮肤炎症和恶性肿瘤具有调节作用。实施例7KS3的特征鉴定KS3编码一个40个氨基酸的多肽(SEQIDNO129)。KS3包含一个23个氨基酸的信号序列，它能产生17个氨基酸的成熟多肽(SEQIDNO348；称为KS3a)。合成制备KS3a(ChironTechnologies，Victoria，Australia)，并观察到其增强转铁蛋白诱导的大鼠肠上皮细胞IEC-18细胞的生长。在96孔平底板中于0.1ml补加0.2％FCS的DMEM(GIBCO-BRLLifeTechnologies)中进行测定。或单独或与750ng/ml脱铁运铁蛋白或与750ng/mlBSA一起将KS3a(SEQIDNO348)、脱铁运铁蛋白、培养基和PBS-BSA滴定到所述板中，并向每孔中加入1×103IEC-18细胞。在含10％CO2的大气中于37℃温育所述板5天。如前所述(J.Imm.Meth.93157-165，1986)通过MTT染料还原测定细胞生长的程度。如图7所示，发现KS3a加上脱铁运铁蛋白增强转铁蛋白诱导的IEC-18细胞的生长，而单独的KS3a或PBS-BSA不能，表明KS3a和脱铁运铁蛋白协同诱导IEC-18细胞的生长。该数据表明，KS3是上皮源性的，并刺激肠上皮细胞生长。这表明KS3对创伤愈合、辐射或药物性肠疾病的保护和肠上皮的完整性具有作用。在所附序列表中给出了SEQIDNO1-465。在所附序列表中使用的多核苷酸或多肽序列的编码符合WIPO标准ST.25(1988)，附录2。本文引用的所有参考文献，包括专利文献和非专利文献，都通过引用整体结合到本文中。尽管已经按照具体的实施方案描述了本发明，但可在不背离本发明范围的情况下进行改变和修饰，本发明的范围仅受限于所附权利要求书的范围。说明书的核苷酸和氨基酸序列表序列表<110>Watson，JamesD.Strachan，LornaSleeman，MatthewOnrust，ReneMurison，JamesG.Kumble，KrishanandD.<120>分离自皮肤细胞的组合物及其使用方法<130>11000.1011c2PCT<160>465<170>FastSEQforWindows版本3.0<210>1<211>696<212>DNA<213>大鼠<400>1aattcggcacgaggccgaggcgggcaggcaccagccagagcagctggcggcagacagtcg60gaccgagacagttggaccgagacagtcgaacggtctaacagggcctggcttgcctacctg120gcagctgcacccggtccttttcccagagctggttctgtgggtcaacatggtcccctgctt180cctcctgtctctgctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccct240cccggcctccttcctggaggaagtggcgggcagtggggaagctgagggttcttcagcctc300ttccccaagcctgctgccgccccggactccagccttcagtcccacaccagggaggaccca360gcccacagctccggtcggccctgtgccacccaccaacctcctggatgggatcgtggactt420cttccgccagtatgtgatgctcattgcggtggtgggctcgctgacctttctcatcatgtt480catagtctgcgcggcactcatcacgcgccagaagcacaaggccacagcctactacccgtc540ctctttccccgaaaagaagtatgtggaccagagagaccgggctggggggccccatgcctt600cagcgaggtccctgacagggcacctgacagccggcaggaagagggcctggacttcttcca660gcagctccaggctgacattctggcttgctactcaga696<210>2<211>475<212>DNA<213>大鼠<400>2cggtatcgataagcttgatatcgaattcctgcaggtcgacactagtggatccaaagaatt60cggcacgagaaaataaccaaccaaacaaactttcctcttcccgctagaaaaaacaaattc120tttaaggatggagctgctctactggtgtttgctgtgcctcctgttaccactcacctccag180gacccagaagctgcccaccagagatgaggaactttttcagatgcagatccgggataaggc240attgtttcacgattcatccgtgattccagatggagctgaaatcagcagttacctatttag300agatacacctagaaggtatttcttcatggttgaggaagataacaccccactgtcagtcac360agtgacaccttgtgatgcgcctttggaatggaagcttagcctccaggagctgcctgagga420gtccagtgcagatgggtcaggtgacccagaaccacttgaccagcagaagcagcag475<210>3<211>381<212>DNA<213>人<220><400>3ctggagatcctggggatccaggtgatcccggtagaaccaggcagatttgttgtagatgac60tggctggtgaggttagtcttcgttccactggacagggaaagcttgaaacttgggctctgc120cgtccagaaaggtttgttttcagaagcacttccttttcctcactttcttttaatttcttc180ctttccatgaatttacttattggatccataatattatcatcatttttagttttgtcagat240ggagacactacagcttctccatcttccatgtcatcttcatctgtgttaaaccacatctct300tcttcatcttctagtgtctggcatctcttcgatatctgtgattcctcaaaatggaacgca360tactgtcaagtttgggggtaa381<210>4<211>311<212>DNA<213>人<400>4agcgtggtcgcggccgaggtactacagactttgtgataaggctgaagcttggggcatcgt60cctagaaacggtggccacagctggggttgtgacctcggtggccttcatgctcactctccc120gatcctcgtctgcaaggtgcaggactccaacaggcgaaaaatgctgcctactcagtttct180cttcctcctgggtgtgttgggcatctttggcctcaccttcgccttcatcatcggactgga240cgggagcacagggcccacacgcttcttcctctttgggatcctcttttccatctgcttctc300ctgcctgctgg311<210>5<211>514<212>DNA<213>小鼠<400>5ctggagctcgcgcgcctgcaggtcgacactagtggatccaaagcttaaaagagactccac60ccactccagtagaccggggactaaaacagaaattctgagaaagcagcaagaagcagaaga120aatagctatttcacagcagtaacagaagctacctgctataataaagacctcaacactgct180gaccatgatcagcccagcctggagcctcttcctcatcgggactaaaattgggctgttctt240ccaagtggcacctctgtcagttgtggctaaatcctgtccatctgtatgtcgctgtgacgc300aggcttcatttactgtaacgatcgctctctgacatccattccagtgggaattccggagga360tgctacaacactctaccttcagaacaaccaaataaacaatgttgggattccttccgattt420gaagaacttgctgaaagtacaaagaatatacctataccacaacagtttagatgaattccc480taccaaccttccaaagtatgtcaaagagttacat514<210>6<211>1059<212>DNA<213>小鼠<400>6ggcacgagcctgctgccctcttgcagacaggaaagacatggtctctgcgcccggatccta60cagaagctcatggggagccccagactggcagccttgctcctgtctctcccgctactgctc120atcggcctcgctgtgtctgctcgggttgcctgcccctgcctgcggagttggaccagccac180tgtctcctggcctaccgtgtggataaacgttttgctggccttcagtggggctggttccct240ctcttggtgaggaaatctaaaagtcctcctaaatttgaagactattggaggcacaggaca300ccagcatccttccagaggaagctgctaggcagcccttccctgtctgaggaaagccatcga360atttccatcccctcctcagccatctcccacagaggccaacgcaccaaaagggcccagcct420tcagctgcagaaggaagagaacatctccctgaagcagggtcacaaaagtgtggaggacct480gaattctcctttgatttgctgcccgaggtgcaggctgttcgggtgactattcctgcaggc540cccaaggccagtgtgcgcctttgttatcagtgggcactggaatgtgaagacttgagtagc600ccttttgatacccagaaaattgtgtctggaggccacactgtagacctgccttatgaattc660cttctgccctgcatgtgcatagaggcctcctacctgcaagaggacactgtgaggcgcaaa720aagtgtcccttccagagctggcctgaagcttatggctcagacttctggcagtcaatacgc780ttcactgactacagccagcacaatcagatggtcatggctctgacactccgctgcccactg840aaactggaggcctccctctgctggaggcaggacccactcacaccctgcgaaacccttccc900aacgccacagcacaggagtcagaaggatggtatatcctggagaatgtggacttgcacccc960cagctctgctttaagttctcatttgaaaacagcagccacgttgaatgtccccaccagagt1020ggctctctcccatcctggactgtgagcatggatacccag1059<210>7<211>861<212>DNA<213>大鼠<400>7gaattcggcacgagaggagagaaagagaagtgtgcacaaagaaacttgtattattattaa60ttagcacctagcttgtttgtgtctgatacaccaccaagtagtaattgttgaaaaaacgaa120gaagaaaaaaaaaaaacaaaaaaaccaaacagtgggtactcaaataagataggagaaaaa180tgagagaacagacccagttctcgacccttgcttctcaaggtcctcccaccaggctgccaa240agcaagatggtgttgctctgatccagtcagtattcttttgacttttttttttaatctcca300ggttttggttcaggctcccatattcataccctggctcatttagctttccctcatgttgtg360ggttcttctgtccctcacccccttactctccccactgatattcttcccagtcaagactgt420ggctctggaagaaatatccaccatttgcagagctgatgttctgtagatcgtaatgttgaa480gcgctgggtgtcctggttggcagaatcactcctgtattactctggtacataggtgtctcc540tgatagactccctggccttagtcatggggtgttttctagaggcagactaagacaggagtc600aaaaaagatttagaggaaggagctgaggaaagaaagacagttgtgggaggaaaatcaagt660tctactcaggatcccgagtgtttctgtagatgtagattggaatgtgtccataacagagag720gccagtgagagacatccccaaggacctgccaggctttccttcgctccaggaagacgcacc780atcactcaaaaggggtttcctagaaagaaagacaagtgacttaaaaaatctgccagtggg840ttcttgaagtcatcgaaccta861<210>8<211>398<212>DNA<213>小鼠<400>8gtcaccagcaaaggtggaaacaaattctttgaaggactctgacagccctgggtctccaag60gctgctgggaccagtcttagcctcttgtggcaagtggtaggaatgtgaatctttgcgacc120agggggatcagaaatggggtctcccatttctggtgtctgcccagtccttccaggtgggct180cttcgtagccctggggtggattttcctcctcttccacagagatgctttttctctgcatac240catgtctgctggtttcccataatctccctcaaacccacaccaccctccactgaggctcag300ccccagagccatgaaaactcccaccagtttccaggatagagtctggacagaactggggcc360ctggttgccaagtggtgaaaaaaggaatggcccccctg398<210>9<211>1060<212>DNA<213>小鼠<220><400>9agaacattcgagaatatgttcggtggatgatgtattggattgtctttgcgatcttcatgg60cagcagaaaccttcacagacatcttcatttcctggtccggcccacggattggcaggccat120ggggttgggaagggcctcaccaccaccaccacctggcctctggctcacacaaacccctcc180ccttgcttacacacaggttcccgttttattacgagttcaagatggcttttgtgctgtggc240tgctctcaccttacaccaagggggccagcctgctttaccgaaagtttgtccacccatccc300tatcccgccatgagaaggagatcgacgcatgtatcgtgcaggcaaaggagcgcagctatg360aaaccatgctcagttttgggaagcggagcctcaacatcgctgcctcagctgctgtgcagg420ctgctaccaagagtcaaggcgctctagctggaaggctacggagtttctctatgcaagacc480tgcgctctatccctgacacccctgtccccacctaccaagatcccctctacctggaagacc540aggtaccccgacgtagaccccctattggataccggccaggcggcctgcagggcagtgaca600cagaggatgagtgttggtcagacaatgagattgtcccccagccacctgttcggccccgag660agaagcctctaggccgcagccagagccttcgggtggtcaagaggaagccattgactcgag720agggcacctcacgctccctgaaggtccgaacccggaaaaaggccatgccctcagacatgg780acagctagagtctgcagattgaggccaccttacctctggagccagcaggggacctttcgc840tgctacaccagctaccggggttctgctccgtctggcttgtgcctaaatggcacatggcgt900ggtaccctgcacagggagacattcactgtaccaaagcagcccaggcctggggcctattta960ttgccttcctctgccttttgctttctcagacatgggaccagagccccaccagtccctacc1020gacgaaaccaaaagtccaaccagctgtgttcattccttct1060<210>10<211>353<212>DNA<213>小鼠<400>10ggaaagtcatctacctgctggtggcctccatcagagccgggagatctccactgtgtgtat60ggagaccgcattgatagcttactctcttcctgaactacaggatgaaggccatggctctga120gcctaggagcaagcccagtgcttgcttttctcctctctgggtacagtgatggttaccaag180tgtgtagtaggttcggaagcaaagtgcctcagtttctgaactagaactacagctctgtct240gccttagcacagacaggcgttgtctcattcctctcacctgccctacccatgcatgactcg300tccgcttattgaggggcaggtgagtcatctgagatgctatttgaaacatgaga353<210>11<211>969<212>DNA<213>小鼠<400>11cggcacgagagagtatgaagccagagtcttagagaagtcactgagaaaagaatccagaaa60caaagagaccgacaaggtgaagctgacctggagggaccgattcccagcctatttcaccaa120tcttgtctccatcatcttcatgatcgcagtgacatttgcaatcgtcctcggagttatcat180ctatagaatctccacagctgcagccttggccatgaactcctccccgtctgtgcggtccaa240catccgggttacagtcacggccaccgctgttatcatcaacctcgtggtcatcattctgct300ggatgaagtttacggctgcattgccaggtggctcaccaagattggtgagtgccatgtgca360ggacagcataggcagcatgggcctagggcagggccagccttgaagtgggcagcctggtca420cagaactgtggctagtcccaacttcccctggcctggcctggctgtgagtggctagcagct480ggcacagtcagtaccgtatgtctctcctcagaggtcccaaagacagagaagagctttgag540gagaggctaaccttcaaggccttcctgctcaagtttgtgaactcttacactcccatcttc600tatgtcgccttcttcaaaggccggtttgttggtcggcccggtgactacgtgtacatcttc660cgctctttccggatggaggagtgtgccccgggcggctgcctcatggagctctgtatccag720ctgagcatcattatgctgggcaagcagctaatccagaacaatctcttcgagattggcatc780ccgaagatgaaaaagttcatccgctacctgaagctgcgcagacagagcccctcagaccgt840gaagagtacgtgaagcggaagcagcgctatgaggtggacttcaacctcgaacctttcgcc900ggcctcacgcccgagtacatggaaatgatcattcagttcggctttgtcaccctgtttgtt960gcgtccttc969<210>12<211>1411<212>DNA<213>小鼠<400>12ggcacgaggcaacttggacactaaagctaggtaccagcctgttagtttacatgagttcaa60aattcaggtcagggtctctgaaatggagtctgaatttaaaagctttggcctctcatgtga120ataatacatatgtcatgtgtcatttgaatagtttcagtcacacacactttgtatttctct180aagtgtaacgcatgtgtagtgggtggttgtagtatgatttctccgtctttcttgtttgaa240tgtttggacttgtgcacgtgtgcacatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtg300tgtgtatttgctcctgtggctatgtgcatgtgccatgtgggtgtgtgtgcttgtgggggc360cagaggttaggtaccttcctctatctctccaccctggtggtttttgttttgttttgtttt420gttttggaccaggtctatcactgataagctaggttggatggcttctgagaagagtctgcc480tctctgtccccctgcccctyctccccccagccctcaggttacagataagtgccacaagtc540cttgtcctttcaagtagcctctagggatccaggctcatatccttgtgcttactgactgag600ccacctctcagctccctcagccccgttttacacgttaactttgtctcctgtctatgcctg660ctctcttcagtgaccccttccgttttcctttcactcttttctctgaatagatttgtgtgc720gagagactattatcatatggatgcataaatatcatctgcaaagtcaatcgcaggaaagac780ttagagtctctttagctttatgactgtaaaggattccgcttcttgccattgattcagctt840ttttgccattgatcctttattagagatcaattagagtcgtatacaaagaccttggctggg900ccctgagggtctatctcaggctaggccctgagggtctatctcaggctaggccctgagggt960ctatctcaggatagatggatttaactgcttttctcaagacgcttttactctctcgttgaa1020ttctttttaaacttttaattgacattgtacttgcattcttatgggaaacagggtgaccca1080cacacatgtgtacacaggtacacacacagtcaggtcagcatagctggtatgttgttgttt1140atgttggggacagtcagattggtattgtttttgcactgtgctgtggaacattggaaaacc1200ttatctgatggtgaccctgtgcctactaacagccctcactaggatacattttggagtctc1260tggcaaccacaattttgctctatttccatgagtccagcatctctactactgcatagaagt1320aaaaaaaaaaaaaaaaaactcgagagtacttctagagcggccgcgggccccccctcgagg1380tcgacggtatcgataagcttgatatcgaatt1411<210>13<211>888<212>DNA<213>小鼠<400>13ggcacgagaggaccttgaccgacatccagaccacgggacccgactggatgtctcaccctg60cccctgcaggccctgtcccttccaaaacaggcacttctgtcacaggatactttttttttt120aacttaaatttgcttgggggaggggagcagttctagttccatgaggcacaaatggaggtc180aaagagcaacttgccgatgtctcttctctcctcccactgtgtgggtagtaggaattgaat240caggttatcgatcttggggctgagccatctctgtggcccacagagcacttatatgtggtt300acttgttgctctcacattgtcagtgtacagcttggtggcctttgtcactggcatgctctg360tgacactgttgtgataaaaatgttgatgagtttacacaaatctagtaaattgaacccaag420agccaagtgtggtggtgtacccttaattccagcactttgggggcaagttcaggtagttct480ctgaatttgagagcctcctggcccacatagtgagttccatggctgcgtagttgcaaaaga540acaccaacacctttcccccacaaatagaattgtactgaaggtcacagtcagagaaagcat600agcaaggatggctgctctgagcccctcctgtgcacttctgtagacctagccccggtgtct660aaatggagtctgattttagcacctgcacttgactgctgtgctccaccctgacccgcctty720tcctgatcccagattgctagaactttgaccaaaatgggacttaattggagttgtgattgg780katgttcattgatttaaagtgctctttacattttaaggaaactaaccctttgggtaagaa840aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa888<210>14<211>547<212>DNA<213>小鼠<400>14gaattcggcacgagcctaaatgctgggattaaaggcgtgcgccactactgccaggctgtt60ttttttttttttttttttttattaatgatctgccagacaaagagatgtcctttttggtgc120aaaagtcacccaatgcttgaagtcactatatttgattagctctgtaactgatacacaaat180aaaactttccattatggataatacattatctattattatttatctcttgttcatttttgc240aatttctgtacttgactcccagttgagtacaaggtgcctttggtggttttccaaggatct300tgaggttacatgaaattgctgatgatgtctgttgaaagcattgtatggaggcctgaggta360tatttggcctgagagcagagtttttaaaatagagcctgctggaaaagctagctggagctt420ctgactactttagaaaggcactgtttgaagcacaggccatgaagtaagacttgctttcta480gttaaattgaggttttttgtttttttaagtcwttagtgtatagagatttcctacattttt540tgtggtt547<210>15<211>318<212>DNA<213>大鼠<400>15ctgacatgaagccccctaagacccaaagattggttcctgctgtgacatgcctaccatgtg60gccacttcttcatgtcctctggcttgctctggtctgtggctctgttcacaccaccctgtc120aaagtcagatgccaaaaaagctgcctcaaagacgctgctggaaaagactcagttttcgga180taaacctgtccaagaccggggtctggtggtgacggacatcaaagctgaggatgtggttct240tgaacatcgtagctactgctcagcaagggctcgggagagaaactttgctggagaggtcct300aggcatatgtcactccat318<210>16<211>856<212>DNA<213>大鼠<400>16gaattcggcacgagcggcacgagcggccccgaagggggctgcacgggcgacttggcggcg60atggctcgagctccggcggcgacgacggtggccggaggcggcggctcctcctccttctcc120tcctgggcttgggcccggcggtgatccgagctggcggccgcggcccccckatgagactgt180tggcgggctggctgtgcctgagcctggcgtccgtgtggctggcgcggargatgtggacgc240tgcggagcccgctctcccgctctctgtacgtgaacatgactagcggccctggcgggccag300cggcggccaccggcggcgggaaggacacgcaccagtggtatgtgtgcaacagagagaaat360tatgcgaatcacttcagtctgtctttgttcagagttatcttgaccaaggaacacagatct420tcttaaacaacagcattgagaaatctggctggctgtttatccaactctatcattcttttg480tatcatctgtttttaccctgtttatgtctagaacatctattaacgggttgctaggaagag540gctccatgtttgtgttctcaccagatcagtttcagagactgcttaaaattaatccggact600ggaaaacccatagacttcttgatttaggtgctggagatggagaagtcacgaaaatcatga660gccctcattttgaagaaatttatgccactgaactttctgaaacaatgatctggcagctcc720agaagaagaaatacagagtgcttggtataaatgaatggcagaatacagggttccagtatg780atgtcatcagctgcttaaatctgctggatcgctgtgatcagcctctgacattgttaaaag840atatcagaatgtcttg856<210>17<211>349<212>DNA<213>大鼠<400>17ccaaagaattcggcacgaggcggctcgggatggcggcccccatggaccggacccatggtg60gccgggcagcccgggcgctgcggcgggctctggcgctggcctcgctggccgggctattgc120tgagcggcctggcgggtgctctccccaccctcgggcccggctggcggcgccaaaaccccg180agccgccggcctcccgcacccgctcgctgctgctggacgccgcttcgggccagctgcgcc240tggagtacggcttccaccccgatgcggtggcctgggctaacctcaccaacgccatccgcg300agactgggtgggcctatctggacctgggcacaaatggcagctacaagtg349<210>18<211>1057<212>DNA<213>大鼠<220><400>18cctgcaggaagggtggcccccagtatcgggtcccccaaaacccttgcgtgaatgacaggt60gtacctcccgcagagagtacatggagatcaactgtcccagggctgtagggaaaagcctgt120aatgggacactccttcccgctgcaggtcgacactagtggatccaaagaattcggcacgag180gcggaagcagccgcaggtatggcggctgccatgccgctgggtttatcgttgctgttgctg240gtgctagtggggcagggctgctgtggccgcgtggagggcccacgcgacagcctgcgagag300gaactcgttatcactccgctgccttccggcgacgtggccgccacattccagttccgcacg360cgttgggattccgatctgcagcgggaaggagtgtcccattacaggctcttccctaaagcc420ctgggacagttgatctccaagtactctctgcgggagctacacctgtcattcacgcaaggc480ttttggaggacccgatactgggggccacccttcctgcaggctccatcaggtgcagagctc540tgggtctggttccaagacactgtcacagatgtggataagtcttggaaggagctcagtaat600gtcctctcagggatcttctgcgcgtccctcaacttcatcgactccaccaataccgtcact660cccacagcctccttcaaacctctggggctggccaatgacactgaccactacttcctgcgc720tatgctgtgctgccccgggaggtcgtctgcaccgagaatctcacgccgtggaagaagctc780ctgccctgtagctccaaggcagggctgtccgtgctactgaaagcagatcgattgttccac840accagttaccactcccaggcagtgcatatccggccaatctgcagaaatgctcactgcacc900agtatctcctgggagctgaggcagaccctttcagttgtctttgatgccttcatcaccgga960caggggaagaaagaggcctgtccattggcatctcagagcctagtttatgtggacatcaca1020ggctacagccaggacaacgaaacactggaggtgagca1057<210>19<211>750<212>DNA<213>大鼠<400>19ggcacgagcggcatctcaagctgctgcaagcaggactgagcactaccagagcagcaacct60cggatggccctggacgtggcacgcgcggggcacagaggcaagaagacttgatgaagcctc120tcttcccaacccatatccagaaagaacgatttagatgacagtttttagaaaggtgaccac180catgatctcctggatgctcttggcctgtgcccttccgtgtgctgctgacccaatgcttgg240tgcctttgctcgcagggacttccagaagggtggtcctcaactggtgtgcagtctgcctgg300tccccaaggcccacctggccctccaggagcaccaggatcctcaggaatggtgggaagaat360gggttttcctggtaaggatggccaagacggccaggacggagaccgaggggacagtggaga420agaaggtccacctggcaggacaggcaaccgaggaaaacaaggaccaaagggcaaagctgg480ggccattgggagagcgggtcctcgaggacccaagggggtcagtggtacccccgggaaaca540tggtataccgggcaagaagggacctaagggcaagaaaggggaacctgggctcccaggccc600ctgtagctgcggcagtagccgagccaagtcggccttttcggtggcggtaaccaagagtta660cccacgtgagcgactgcccatcaagtttgacaagattctgatgaatgagggaggccacta720caatgcatccagtggcaagttcgtctgcag750<210>20<211>849<212>DNA<213>大鼠<400>20gataatycggsacgaggggccgccgagtcccgccgggtcggtgtagctcgctgccgacgc60tgcgacgctcgtgggtgccgtgttcggcttttcctgtctacttcagtgcaccgctgcagc120tccggcctcgggtctgacgcgccacagcatggcttccgctttggaggagttgcagaaaga180cctagaagaggtcaaagtgctgctggaaaagtccactaggaaaagactacgtgatactct240tacaaatgaaaaatccaagattgagacggaactaaggaacaagatgcagcagaagtcaca300gaagaaaccagaatttgataatgaaaagccagctgctgtggttgctcctcttacaacagg360gtacactgtgaaaatcagtaattatggatgggatcagtcagataagtttgtgaaaatcta420cattactttaactggagttcatcaggttcctgctgagaatgtgcaagtacacttcacaga480gaggtcatttgatcttttggtaaaaaacctcaatggcaagaattactccatgattgtgaa540caatcttttgaaacctatctctgtggaaagcagttcaaaaaaagtcaagactgatacagt600tattatcctatgtagaaagaaagcagaaaacacacgatgggactacttaactcaggtgga660aaaagaatgcaaagagaaagaaaagccttcctacgacactgaggcagatcctagtgaggg720attaatgaatgttctaaagaaaatttatgaagatggagatgatgacatgaagcgaaccat780taataaagcgtgggtggaatcccgagagaagcaagccagggaagacacagaattcctgca840gcccggggg849<210>21<211>312<212>DNA<213>人<400>21ttcgagcggccgcccgggcaggtaccagcacatgctgtggtgatgctggtttgtgttccc60acctcactcacactcagccctggcatctcctctcctggctctgtttgagtggcagcgtca120atggcctttctgctctggagctcgtccctgtggctgctgaagtagtcttcctcactaaca180gtagaggactcacagtcatggggcttgcgctctgccttgcctctgcgggcatctctgggt240ccaggtccgccttcctgggagtacctcggccgcgaccaacgctaatcaagcttatcgata300ccgtcgacctcg312<210>22<211>1023<212>DNA<213>小鼠<400>22gcgcggcccgggggactcacattccccggtcccccctccgccccacgcggctgggccatg60gacgccagatggtgggcagtagtggtactcgccacactcccttccttgggagcaggtgga120gagtcacccgaagcccctccgcagtcctggacacagctgtggctcttccgcttcttgttg180aatgtagcgggctatgccagctttatggtacctggctacctcctggtgcagtacttaaga240cggaagaactacctggagacaggcaggggtctctgcttccccctggtgaaagcctgtgtg300tttggcaatgagcccaaggctcctgatgaggttctcctggctccgcggacagagacagcg360gaatccaccccgtcttggcaggtcctgaagctggtcttctgtgcctcgggtctccaggtg420tcctatctgacttggggcatactgcaggaaagagtgatgactggcagctacggggccaca480gccacatcaccaggagagcatttcacagactcccagtttctggtgctgatgaaccgtgtg540ctggcgctggttgtggcaggcctctactgtgtcctgcgcaagcagccccgtcatggtgca600cccatgtaccggtactcctttgccagtctgtcaaatgtgcttagcagctggtgccagtat660gaagcacttaagttcgtcagcttccctacccaggtgctggcgaaggcctccaaggtgatc720cctgtcatgatgatgggaaagctggtgtcccggcgcagctatgaacactgggaatacctg780actgccggcctcatctccattggagtgagcatgtttcttctatccagtggaccagagcct840agaagctctccagccaccacactctctggcttggtcctactggcaggctatattgctttc900gacagcttcacctcaaattggcaggatgccctgtttgcctataagatgtcatcggtgcag960atgatgtttggggtcaatttattctcctgtcttttcacagtaggctcactactggaacag1020ggg1023<210>23<211>997<212>DNA<213>小鼠<400>23ggcacgaggacttctgctagtacttgctcctggcggtggctgagcaaccggtctcaccag60catgctctgcctgtgcctgtatgtgcccatcgccggggcggctcagactgagttccagta120ctttgagtccaaggggcttcctgccgagctgaaatccatcttcaaactcagtgtctttat180cccctctcaagagttctccacataccgccaatggaagcagaaaattgtgcaagcaggtga240caaggaccttgatgggcaactggactttgaagagtttgtacattacctccaagatcatga300gaaaaaactgaggctggtgttcaagagtctggacaaaaagaatgatggtcgaatcgatgc360tcaggagatcatgcagtccctgcgggacctgggtgtcaagatctcggaacagcaggcgga420gaagattcttaagagcatggataagaatggcacgatgaccatcgactggaacgagtggag480ggactaccacctcctgcaccctgtggagaacatcccggagatcatcctgtactggaagca540ctcgacgatcttcgatgtcggtgagaatctgacagtcccagatgagttcacagtggagga600gaggcagacggggatgtggtggaggcacctggtggcaggaggtggggcaggggcagtttc660cagaacctgcactgcccccctggacagactgaaggtgctcatgcaggtccatgcctcccg720cagcaacaacatgtgcatcgtaggtggattcacacagatgattcgagaagggggagccaa780gtcactctggcggggcaacggcatcaatgtcctcaaaattgcccctgagtcggccatcaa840attcatggcatatgagcagatgaaacggcttgtcggtagtgatcaggagacgctgaggat900ccacgaaaggcttgtggcaggctccttggccggagccattgcccagagtagcatctaccc960aatggaggttctgaagacccgaatggccctgcggaaa997<210>24<211>529<212>DNA<213>大鼠<400>24aaagcttccatcctcaacatgccactagtgacgacactcttctacgcctgcttctatcac60tacacggagtccgaggggaccttcagcagtccagtcaacctgaagaaaacattcaagatc120ccagacagacagtatgtgctgacagccttggctgcgcgggccaagcttagagcctggaat180gatgtcgacgccttgttcaccacaaagaactggttgggttacaccaagaagagagcaccc240attggcttccatcgagttgtggaaattttgcacaagaacagtgcccctgtccagatattg300caggaatatgtcaatctggtggaagatgtggacacaaagttgaacttagccactaagttc360aagtgccatgatgttgtcattgatacttgccgagacctgaaggatcgtcaacagttgctt420gcatacaggagcaaagtagataaaggatctgctgaggaagagaaaatcgatgtcatcctc480agcagctcgcaaattcgatggaagaactaaggttcttttgctacccaga529<210>25<211>1230<212>DNA<213>大鼠<400>25aagaattcggcacgaggccatggctggttgggcgggggccgagctctcggtcctgaaccc60gctgcgtgcgctgtggctgttgctggccgccgccttcctgctcgcactgctgctgcagct120ggcgcccgccaggctgctaccgagctgcgcgctcttccaggacctcatccgctacgggaa180gaccaagcagtccggctcgcggcgccccgccgtctgcagggccttcgacgtccccaagag240gtacttttctcacttctacgtcgtctcagtgttatggaatggctccctgctctggttcct300gtctcagtctctgttcctgggagcgccgtttccaagctggctttgggctttgctcagaac360tcttggggtcacgcagttccaagccctggggatggagtccaaggcttctcggatacaagc420aggcgagctggctctgtctaccttcttagtgttggtgttcctctgggtccatagtcttcg480gagactcttcgagtgcttctacgtcagcgtcttctctaacacggccattcacgtcgtgca540gtactgtttcgggctggtctactatgtccttgttggcctgaccgtactgagccaagtgcc600catgaatgacaagaacgtgtacgctctggggaagaatctactgctacaagctcggtggtt660ccacatcttgggaatgatgatgttcttctggtcctctgcccatcagtataagtgccacgt720cattctcagcaatctcaggagaaataagaaaggtgtggtcatccactgccagcacagaat780cccctttggagactggttcgagtatgtgtcttctgctaactacctagcagagctgatgat840ctacatctccatggctgtcaccttcgggctccacaacgtaacctggtggctggtggtgac900ctatgtcttcttcagccaagccttgtctgcgttcttcaaccacaggttctacaaaagcac960atttgtgtcctacccaaagcataggaaagctttcctcccgttcttgttttgaacaggctt1020tatggtgaagagcgcagcccaggtgacaggttcccttcctcgagacgctgagacaggctg1080aagtacactttctgcagctggcgcccgccaggctgctaccgagctgcgcgctcttccagg1140acctcatccgctacgggaagaccaagcagtccggctcgcggcgccccgccgtctgcagcc1200cgggggatccactagttctagagcgccgcc1230<210>26<211>393<212>DNA<213>大鼠<400>26ggcagcaagaagcaacccgcaagctaggagtctgtcagcgagggcaggggctgcctggtt60ggggtaggagtgggagcagggccagcaggagggtctgaggaagccattcaaagcgagcag120ctgggagagctggggagccgggaagggcctacagactacaagagaggatcctggcgtctg180ggcctcctgggtcatcaccatgaggccacttcttgccctgctgcttctgggtctggcatc240aggctctcctcctctggacgacaacaagatccccagcctgtgtcccgggcagcccggcct300cccaggcacaccaggccaccacggcagccaaggcctgcctggccgtgacggcctgatggc360cgcgacggtgcacccggagtccgggagagaaac393<210>27<211>778<212>DNA<213>大鼠<400>27ctgcaggtcgacactagtggatccaaagattcggcacgagataaggcacatttgcttcat60aaaataaaaaaaaaggaaatttacttagccgcatgtcagtcacccaaattttgagtgtac120aaatgaaatggaaaacatttattacacaaatttaattacaattctagggaataaacatgc180aaatcagatggagctcaatctgcaggcgctgatcctctccccctggtttgcagtctgtgc240acctcctggattcgcccgcgaccaggcagtcagaggcctggctcttgcaggcaggaggat300cactgttgtaaagaacagcgtcacatttagcgcatctggcgtagtagcagtttttaacac360tttgcgcaggtgcctcccttcccccacccgcgctttgttaggtctacctctctaaatctc420tgccttcctcgcacagtaagtgacctctccatgacaaagggcccccagacagcagttata480aatcaatgtgttttgggtttgtttgtttgtttgttttgttttaaagaaaaacccggccat540gcttggtggcacttgcctttaatagtagcgcttggtagacagaggcaagcggttctctgt600aagttcaaggccagcctggtctacacagtgagaccgggtctcaaaaacaaaacaacaaaa660aacaactcctattgaatccactacaggaagggggggcgcggatcactgtctgcaaactaa720agtgacttgagctcctgtcacagcctttccagcaagggcaagcttctttattagttat778<210>28<211>1123<212>DNA<213>大鼠<400>28gggccccccctcgagtcgacgktatcgataagcttgatatcgaattcctgcaggtcgaca60ctagtggatccaaagaattcggcacgagcctgaggcgactacggtgcgggtgccgggtgc120cgggtgcctacagcccccatcagcttccccggggagattctgccgatttgtcacgagcca180tgctcaggaggcagctcgtctggtggcacctgctggctttgcttttcctcccattttgcc240tgtgtcaagatgaatacatggagtctccacaagctggaggactgcccccagactgcagca300agtgttgccatggagattatggattccgtggttaccaagggccccctggacccccaggtc360ctcctggcattccaggaaaccatggaaacaatggaaataacggagccactggccacgaag420gggccaagggtgagaaaggagacaaaggcgacctggggcctcgaggggaacgggggcagc480atggccccaaaggatagaagggatacccaggggtgccaccagagctgcagattgcgttca540tggcttctctagcgactcacttcagcaatcagaacagtggcattatcttcagcagtgttg600agaccaacattggaaacttcttcgatgtcatgactggtagatttggggcccccgtatcag660gcgtgtatttcttcaccttcagcatgatgaagcatgaggacgtggaggaagtgtatgtgt720accttatgcacaatggtaacacggtgttcagcatgtacagctatgaaacaaagggaaaat780cagatacatccagcaaccatgcagtgctgaagttggccaaaggagatgaagtctggctaa840gaatgggcaacggtgccctccatggggaccaccagcgcttctctaccttcgcaggctttc900tgctttttgaaactaagtgatgaggaagtcaggatagctccatgctaagggcgatttgta960ggtgagctagggttgttaggatctgaggggtgttggagttgggcttctctatggagtatt1020taactgttacattggtcacactgctactcattctaatggcataccaattatgttggatac1080tttaggggctaggaagaatagaccacaaggtaatattcccaga1123<210>29<211>849<212>DNA<213>大鼠<400>29aattcggcacgaggtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaag60gttattctcctggttcactggctgttgacaacctggggctgcttggcgttctcaggctcc120tatgcttggggcaacttcactatcctggccctgggtgctgtgggctgtggcccagcggga180ctctgttgatgccattggcatgtttcttggtggcttggttgccaccatcttcctggacat240tatctacattagcatcttctactcaagcgttgccgttggggacactggccgcttcagtgc300cggcatggccatcttcagcttgctgctgcaagcccttctcctgctgcctcgtctaccaca360tgcaccgggcagcgagggggtgagctcccgctccgctcggatttcttcggaccttctcag420gaacatagtgcctaccagacaattgactcgtcagactcacctgcagacccccttgcaagc480ctggagaacaagggccaagctgccccccgggggtactgaagctgtccctggccgtcctgg540ggcccagcaggatgcttgtcaccttctttactggacctacaatggggtatcctccattcc600ctgccacagaggtggcctgagtcatgtgccctcggaggtcccagctgagaagagcccagt660cctaattctccatgctgcccctccattcaagacacctgttaacccctgggctagaactgt720ggttggtttcttcccctcctccccatcactataacacacaaccgccgagctgtgcagagt780gttcagggccatccaggccttatgggccaatgatcactgcctctcaggctaccccaaggt840gacccagcc849<210>30<211>1015<212>DNA<213>大鼠<220><400>30gaattcggcacgagggagcaagaagcaacccgaagctaggagtctgtcagcgagggcagg60ggctgcctggttggggtaggagtgggagcagggccagcaggagggtctgaggaagccatt120caaagcgagcagctgggagagctggggagccgggaagggcctacagactacaagagagga180tcctggcgtctgggcctcctgggtcatcaccatgaggccacttcttgccctgctgcttct240gggtctggcatcaggctctcctcctctggacgacaacaagatccccagcctgtgtcccgg300gcagcccggcctcccaggcacaccaggccaccacggcagccaaggcctgcctggccgtga360cggccgtgatggccgcgacggtgcacccggagctccgggagagaaaggcgagggcgggag420accgggactacctgggccacgtggggagcccgggccgcgtggagaggcaggacctgtggg480ggctatcgggcctgcgggggagtgctcggtgcccccacgatcagccttcagtgccaagcg540atcagagagccgggtacctccgccagccgacacacccctacccttcgaccgtgtgctgct600caatgagcagggacattacgatgccactaccggcaagttcacctgccaagtgcctggtgt660ctactactttgctgtccatgccactgtctaccgggccagcctacagtttgatcttgtcaa720aaatggccaatccatagcttctttcttccagttttttggggggtggccaaagccagcctc780gctctcagggggtgcgatggtgaggctagaacctgaggaccaggtatgggttcaggtggg840tgtgggtgattacattggcatctatgccagcatcaaaacagacagtaccttctctggatt900tctcgtctattctgactggcacagctccccagtcttcgcttaaaatacagtgaacccgga960gctggcacttgctcctagtggagggtgtgacattggtccagcgcgcataccagga1015<210>31<211>452<212>DNA<213>人<400>31ttcgagcggccgcccgggcaggttgaaactttagaaagaagagccgggaggatgtattgg60ttgttaggaaaatgtaggctaccagtagaaaatgacattctctattaataagatctgagg120tgcgacacacataattgtcccaatttttaagattgatggggagcatgaagcattttttta180atgtgttggcaggccccattaaatgcataaactgcataggactcatgtggtctgaatgta240ttttagggctttctgggaattgtcttgacagagaacctcagctggacaaagcagccttga300tctgagtgagctaactgacacaatgaaactgtcaggcatgtttctgctcctctctctggc360tcttttctgctttttaacaggtgtcttcagtcagggaggacaggttgactgtggtgagtc420caggacaccaaggcctactgcactcgggaacc452<210>32<211>434<212>DNA<213>小鼠<400>32accaccaagcagatggaatgctggcacacccatgcacctgcatggcgtcacaggtggaag60attgttaaaaaattgacatcagaaatatttacagaaatagatacctgtttgaataaagtt120agagatgaaatttttgctaaacttcaaccgaagcttagatgcacattaggtgacatggaa180agtcctgtgtttgcacttcctgtactgttaaagcttgaaccccatgttgaaagcctcttt240acatattctttttcttggaattttgaatgttcccattgtggacaccagtaccaaaacagg300tgtgtgaagagtctggtcacctttaccaatattgttcctgagtggcatccactcaatgct360gcccattttggtccatgtaacagctgcaacagtaaatcacaaataagaaaaatggtgttg420gaaagagcgtcgcc434<210>33<211>903<212>DNA<213>小鼠<400>33ctgcaacaaggctgttggttcctctccaatgggctccagtgaagggctcctgggcctggg60ccctgggcccaatggtcacagtcacctgctgaagaccccactgggtggccagaaacgcag120tttttcccacctgctgccctcacctgagcccagcccagagggcagctacgtgggccagca180ctcccagggcctcggcggccactacgcggactcctacctgaagcggaagaggattttcta240aggggtcgacaccagagatgctccaagggcctgcaccaagttgcttttgggttttttctg300gtatttgtgttttctgggattttatttttattattttttttaatgtcctttctttgggta360atagagaaatctctgcaaaagactttgctgaccaaccagctggagctcaaggaatgtggg420gtatctggggccacaccattacctgtgggcttgctcctggagccaaaccctgcagcctta480agagagaggggcctgacctgctctctttccctccctagctccaggcctcctctcctgcct540cgtcactcctgtgttctggcctcttgagtgcctttggaggtgtctctgacctgtgaggat600cagagacagtccccgtttttaaacttcgacaattgacttttatttccttttctaattttt660attattttttaaaacaaccaggatgattatcacatctactcccccatccgtccagaaaag720ccccaaattgattccttcagggtctggcctgcccaggctctattccacatgtgcaggttc780caacagcttaaccctattctcttcccagtcatctgctgcaggtatagctgtctcatgccc840ctgcctgcctattctggccagtaccctaagccccaagatctccagcccctgccccagtat900cct903<210>34<211>1359<212>DNA<213>小鼠<220><221>不确定<222>(644)...(644)<400>34caaagaattcggcacgagaccggcctcactatgtctgccattttcaattttcagagtctg60ttgactgtaatcttgctgcttatatgtacatgtgcttatatccgatccctggcacccagc120atcctggacagaaataaaactggactattgggaatattttggaagtgtgcccgaattggg180gaacgcaagagtccttatgtcgccatatgctgtatagtgatggccttcagcatcctcttc240atacagtagctttggaaactaccagcatgtgcttgctatcagactgtaaacaaggacttg300cctccagaaaataatgggaagaatggttaagccatttgtctctgaacatggaatgagata360aacttcaagatgctgttctctatttttatgctattggaccaatgagctgaatgaataatt420aagatgtaacagttcaatacacaggaatgtgattgtatccatcaacctcagttctctcac480tccagtattacattctgcaaatgtcattctgttgtgtcaggactgcttttcataaggttc540ttcgggcacgaagtagaaacccagtggcaaattccaaggctcctttgactagggcttcaa600aataatgtcttcacagaatggtacctctagcgactgtcctattnttattgagaaaaaaac660ttgttctatttttgttgttgttactgttcttatggattgcattcatatttaaaccctttg720gattgctaaccagagtacctctattcttggcaaattccgcagtttattacaggtgtttaa780agtattttaaacaaaactctgaatttctttagttagcctaagagttggcttctagtcaca840aagatacagctgccacactgtgacgaagagcaccttagaaagaaaagcagcaagtgagcg900gtgagcaagtaagcaccgtgcagtcttcgtgcaagtaagcaccgtgcagtcttcgttctc960tgtagtcttgtcttccaaatagaacgtccatcgtagttacccaaaggtggtatttgtggt1020gttcttaatgcagtgctttaagtctagtgtatgttctgtcagcttgaactggaatctctc1080ttgtaactttgtaggttataaacatatctcatatctgctttagtctgggtactatgctct1140aagtacatttcagctttgacacagaatgtgaatagacgaatatcaaaggatacttacaag1200tttgtatccaacatttcttcaggttcagctgaaaatcagttactgtttcaaaacaaagag1260gaattaaatcctagctgaaaactatacatagcatttattaattaattactgggtttaact1320gctctttttaaaagtttgaaaaaaaaaaaaaaaaactcg1359<210>35<211>797<212>DNA<213>小鼠<400>35aattcggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgct60ggttgcgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcc120catctggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagta180cttaagtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcag240cgtggatcaactcatggagctggccgggttgagctgtgccacggctattgccaaggctta300tccccccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaa360taacggaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaac420tatctattaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtca480gaaaatggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaaggga540aaccctagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgca600actcactttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagag660aagaagtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacag720taagggaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaa780aaaaaaaaaaaaactcg797<210>36<211>896<212>DNA<213>小鼠<400>36ttaaggttttcagactttatttcatggtatttgacattgacacatactgagttagtaaca60agataccatgcagctccctctagcctcggatcaccgaagcaggaagaaggtcagactgcc120cccatcccagatttgcttagtttgtctcccaatgtgctggactttaaagacagggaatgg180agaagcagatggatgcttcagtttcagtcatttttggctctatagtgatctctgccttcc240tgtacctgtccttggctggaccctgggcagtaactgtcactcagatgaggacgatcatca300ttacaatggaccaactgagggatgccctcatattagaccaattaaaagttgctgtgagtt360aaaccaggaatgaccgcacttccacatcagaaatcaaacaaaatcaatggttgaagaaca420tggttaggagcctggctaggtatctttgagagatggatgcagctggctactcaggcaggt480aagcaatggaggtcagccacaccctatcgtgatgcactccccatgttcagggtaactgaa540gaagtgggtaaggccagctgaaggccagtcagggcaacttagatgtagcctggcttctac600ttccagcctccggggacaggcaaacacattttgggaagtaagatgatgtcccaattatta660tcagttttttgatatcacagtattgtcacagggagcactgggggtccaggctagcctggg720gtgaggctggccctcagcacacacaggagagcagcttaagtgggacctaaaaaggaccca780atgttacttggtttaatgaaggccccctcaaccccaacagcccctcctgctcagggacac840agttctcacccaattacacattaataacacacaaacagtgcctagcaatgggccag896<210>37<211>501<212>DNA<213>小鼠<400>37ctgcaggtcgacactagtggatccaaagaattcggcacgagaatcatggcgccgtcgctg60tggaaggggcttgtaggtgtcgggctttttgccctagcccacgctgccttttcagctgcg120cagcatcgttcttatatgcgactaacagaaaaggaagatgaatcattaccaatagatata180gttcttcagacacttctggcctttgcagttacctgttatggcatagttcatatcgcaggg240gagttcaaagacatggatgccacttcagaattaaagaataagacatttgataccttaagg300aatcacccatctttttatgtgtttaaccatcgtggtcgagtgctgttccggccttcagat360gcaacaaattcttcaaacctagatgcattgtcctctaatacatcgttgaagttacgaaag420tttgactcactgcgccgttaagctttttacaaattaaataacaggacagacacagaattg480agtattggagtttggggtgta501<210>38<211>766<212>DNA<213>小鼠<400>38gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaaagagcatgtccaaggtaccggggccaggagcactgc420ctgcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgag480aagcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagt540tgagagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagc600ataagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacatttta660tagctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcat720tacaagtggctttttgctgggcggttggcggggggcggggggacct766<210>39<211>480<212>DNA<213>小鼠<400>39ggcacgaggaagcctcttcccatggaagcacactctaggagagagaaggcctctgggctc60cgcctggcctggcattatgaatgcagtggggtcagtgtgtggtggatgtgtgtactgggt120tggctttcctttttagtttttttactttttagtttagtttgttcttttccttccccaata180aatcattctcacatgcttccatgtttgtttctgagaggtgggggctcaaatgtatagaaa240gtaggccccagtccataaggaggtgtgaacacacccccttactgcttatcacccatttga300caggaacgcccaggaggggagggggaggggaagaggtgagttctgcacagtcggacattt360ctgttgcttttgcatgtttaatatagacgttcctgtcgatccttgggagatcatggcctt420cagatatgcacacgacctttgaattgtgcctactaattatagcaggggacttgggtaccc480<210>40<211>962<212>DNA<213>小鼠<400>40ggcacgagattagcggctcctcagcccagcaaatcctccactcatcatgcttcctcctgc60cattcatctctctctcattcccctgctctgcatcctgatgagaaactgtttggcttttaa120aaatgatgccacagaaatcctttattcacatgtggttaaacctgtcccggcacaccccag180cagcaacagcaccctgaatcaagccaggaatggaggcaggcatttcagtagcactggact240ggatcgaaacagtcgagttcaagtgggctgcagggaactgcggtccaccaaatacatttc300ggacggccagtgcaccagcatcagccctctgaaggagctggtgtgcgcgggcgagtgctt360gcccctgccggtgcttcccaactggatcggaggaggctacggaacaaagtactggagccg420gaggagctctcaggagtggcggtgtgtcaacgacaagacgcgcacccagaggatccagct480gcagtgtcaggacggcagcacgcgcacctacaaaatcaccgtggtcacggcgtgcaagtg540caagaggtacacccgtcagcacaacgagtccagccacaactttgaaagcgtgtcgccagc600caagcccgcccagcaccacagagagcggaagagagccagcaaatccagcaagcacagtct660gagctagacctggactgactaggaagcatctgctacccagatttgattgcttggaagact720ctctctcgagcctgccattgctctttcctcacttgaaagtatatgctttctgctttgatc780aagcccagcaggctgtccttctctgggactagcttttcctttgcaagtgtctcaagatgt840aatgagtggtttgcagtgaaagccaggcatcctgtagtttccatcccctcccccatccca900gtcatttctttaaaagcacctgatgctgcattctgttacagtttaaaaaaaaaaaaaaaa960aa962<210>41<211>794<212>DNA<213>小鼠<400>41ggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttg60cgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatct120ggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaa180gtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtgg240atcaactcatggagctggccgggttgagctgtgccacggctattgccaaggcttatcccc300ccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacg360gaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatct420attaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaa480tggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccc540tagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgcaactca600ctttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaa660gtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagg720gaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaaaa780aaaaaaaactcgag794<210>42<211>1152<212>DNA<213>小鼠<400>42ggcacgagcttctcagggcctgccacccaaataagtctggccctagcctcaactctctct60caggctgggccacaggaagctgctgactggccacttgacaccctccccctaaagctaatg120tctgtgactatagggaggttagcactttttctaattggaattcttctctgtcctgtggcc180ccatccctcacccgctcttggcctggaccagatacatgcagcctctttctccagcacagc240ctttccctgagcctgaggttagggcagagtttagagggtgggctaagtgtatgttttcat300gtatgcattcatgcctgtgagtgtgtggcttgctgtcgtgtcctctgggatcccaagcca360cgcgggtcttccctctgtagatgggtcctgggttctatcacctgcttatttatgtacgag420gttggggggtggacccagggtgggttgattgtctctttgtaaggaagtatgtgtcggggg480tgacacgaggctaagcccgagaaaccccgggagacagcactgcataagaaactggtttcc540magactgcagagggagctgcacttttgttttgaccaaaaacaaaaaacaaaacaaaacaa600aaacaaaacaaaaataactctgaagggcgggaggatacccaagcctgatgcctgagagga660gtccctagacttcagcaactccgctgcgtggcctgagcccagcgggagggatggggagag720aattttttggagtccgtgcctgtggtgggcagtcctgagccttcagctgaagcagtgctt780tttggctgccctcacctcgcactacttgaccttgaggctctgagtatctcctgtgcacag840gagaagctcctgcaccagaaagcaccaaarsccmtggcaccccatcttactccactctcc900ccagggactcccaggtgggaactgctgtggcagtgagctcagcccggacagacactgcca960accctgtctcctggcattgggctccggctctacctccccaagcagggcgaggccccgcct1020tctcagcctagcaccacctgtccccgagtcttctcagcttgcccatcattctcggcgccc1080acacaggtgacagtcccaagtagataacctccatgggacaagttgggtgttgccttaccc1140gcctgcccagcc1152<210>43<211>446<212>DNA<213>小鼠<400>43ggcacgagcttgagtctggagtgctgcaaataatagtatgcactatccctgcctggcatg60tttgtttgttaatgtgcactggtgttttgcctggatgtgtatacttgtgaagatgtcaga120actcctggagctggagttagagacaatggtgagctgccttgtggatgttgggaattgaac180ccaggtcctctggagaaataaccagtgctcttaaccactaagccatctcaacagccccaa240attatttttttaataagttgcctcggtcatgttgtcttaatcagagcgatagaaaagtaa300ctaatatagattatttatgaattcaggtggcttaatggtatatgcatgaattagtagtaa360aacaagaactagggccagcaagtggcttaagggtgcctgctaaccatctcagccacctga420gttcagtctccaggaaccacacagtg446<210>44<211>391<212>DNA<213>小鼠<400>44ggcacgagcccacgtctatgttcaccttcgttgttctggtaatcaccatcgtcatctgtc60tctgccacgtctgctttggacacttcaaatacctcagtgcccacaactacaagattgaac120acacagagacagatgccgtgagctccagaagtaatggacggccccccactgctggcgctg180tccccaaatctgcgaaatacatcgctcaggtgctgcaggactcagagggggacggggacg240gagatggggctcctgggagctcaggcgatgagcccccatcgtcctcctcccaagacgagg300agttgctgatgcctcctgatggcctcacggacacagacttccagtcatgcgaggacagcc360tcatagagaatgagattcaccagtaaggggt391<210>45<211>516<212>DNA<213>大鼠<400>45cctcctgtctctgctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccct60cccggcctccttcctggaggaagtggcgggcagtggggaagctgagggttcttcagcctc120ttccccaagcctgctgccgccccggactccagccttcagtcccacaccagggaggaccca180gcccacagctccggtcggccctgtgccacccaccaacctcctggatgggatcgtggactt240cttccgccagtatgtgatgctcattgcggtggtgggctcgctgacctttctcatcatgtt300catagtctgcgcggcactcatcacgcgccagaagcacaaggccacagcctactacccgtc360ctctttccccgaaaagaagtatgtggaccagagagaccgggctggggggccccatgcctt420cagcgaggtccctgacagggcacctgacagccggcaggaagagggcctggacttcttcca480gcagctccaggctgacattctggcttgctactcaga516<210>46<211>306<212>DNA<213>小鼠<400>46gtcaccagcaaaggtggaaacaaattctttgaaggactctgacagccctgggtctccaag60gctgctgggaccagtcttagcctcttgtggcaagtggtaggaatgtgaatctttgcgacc120agggggatcagaaatggggtctcccatttctggtgtctgcccagtccttccaggtgggct180cttcgtagccctggggtggattttcctcctcttccacagagatgctttttctctgcatac240catgtctgctggtttcccaaaatctcccgcaaacccacaccaccctccactgaggctcag300ccccag306<210>47<211>439<212>DNA<213>小鼠<400>47gaaaactcgcaggacgctcactggacagcttgggcttttttcagttgattttatggtttg60catctttctctttctctttttctgtttcttgttcccctttccccttttcctggtgagaaa120gcacatattactgagccattgcaagcaatgggaggggtccacaatgacacacacacacac180acacacacacatacacatacacacacccccgagacagtgccagagctaacagcctacatg240tgtattttggccaaacttggaaaataggtttccttcttcgttttgcttccagccttttat300ttgcaagtgatcttccatgcagtatgaaacatgcagacagcactggagtgtggcaagagt360gagcttgccccacaagtctctcggggatgttgtactcttgtgtgtgtttacagtatcatg420gctgttacatctactggtc439<210>48<211>159<212>DNA<213>小鼠<220><221>不确定<222>(3)...(3)<400>48cangtacgctcactggaacagcttgggcttttttcagttgattttatggtttgcatcttt60ctctttctctttttctgtttcttgttcccctttccccttttcctggtgagaaagcacata120ttactgagccattgcaagcaatgggaggggtccacaatg159<210>49<211>465<212>DNA<213>大鼠<400>49gtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaaggttattctcctgg60ttcactggctgttgacaacctggggctgcttggcgttctcaggctcctatgcttggggca120acttcactatcctggccctgggtgctgtgggctgtggcccagcgggactctgttgatgcc180attggcatgtttcttggtggcttggttgccaccatcttcctggacattatctacattagc240atcttctactcaagcgttgccgttggggacactggccgcttcagtgccggcatggccatc300ttcagcttgctgctgcaagcccttctcctgctgcctcgtctaccacatgcaccgggcagc360gagggggtgagctcccgctccgctcggatttcttcggaccttctcaggaacatagtgcct420accagacaattgactcgtcagactcacctgcagacccccttgcaa465<210>50<211>337<212>DNA<213>大鼠<220><400>50ctcgtgccgaaatcggcagagcgtcgctcctgtgctgtgggnctaagctggncgnctgtg60gnatcgtcctcagcgnctggggagtgatcatgttgataatgctcgggatatttttcaatg120tccattctgctgtggtaatttagnatgtccccttcacagagaaagattttnagaacggcc180ctcagaacatatacaacctgtacgagcaagtcagctacaactgtttcatcgccgcgggcc240tctacctcctcctcgggggcttctccttctgcnaagttcgtctcaataagcgcaaggaat300acatggtgcgctagagcgnagtccnactctccccatt337<210>51<211>371<212>DNA<213>大鼠<220><221>不确定<222>(80)...(80)<221>不确定<222>(312)...(312)<221>不确定<222>(319)...(319)<221>不确定<222>(353)...(354)<400>51gatgcgccctggagccgactgggctgcggtctgcgctttgtggccttcctggcgaccgag60ctgctccctcccttccagcnggcgaattcagcccgacgagctgtggctttaccggaaccc120gtacgtgaaggcggaatacttccccaccggccccatgtttgtcattgcctttctcacccc180actgtccctgatcttcttcgccaagtttctgaggaaagctgacgccgaccgacagcgagc240aagcctgcctcgctgccagccttgccctagcgctaaatggtgtctttaccaacatcataa300gactgatagtgngcaaggncacgcccaaattgcttctaccgagtgttccccgnncgggat360tgcccattctt371<210>52<211>228<212>DNA<213>大鼠<400>52ttccgcgggcgtcatgacggctgcggtgttctttggttgcgccttcatcgccttcgggcc60cgcgctctccctttacgtcttcaccatcgccactgatcctttgcgagtcatcttcctcat120cgccggtgccttcttctggttggtgtctctgctgctttcgtctgttttctggttcctagt180gagagtcatcactgacaacagagatggaccagtacagaattacctgct228<210>53<211>361<212>DNA<213><400>53cgtggacactgctgaggaatgataccgagtggtaggtcagaagaagatgctgtgaacacc60aggactttaatcttatgcttgaaaatgccagatgttgttcgggggacaacttgtatcttt120ctagcagcagatctgtagtttgtatagcctcaacaacaattttaaataagatggagaata180aattattgaggggactaggctatatgcatttgccttcatccacccatgtttattaagaat240cattgtgcttaataataccaagactaagcaccataaccaagaaatactaatgtaaagatt300gtttcttgtttcaggaatggttaattcttcaacgttggtatgataatgataacttgtttt360g361<210>54<211>403<212>DNA<213><220><400>54ttgcgtggtcgcggccgaggtgtctgttcccaggagtccttcggcggctgttgtgtcagt60ggcctgatcgcgatggggacaaaggcgcaagtcgagaggaaactgttgtgtctcttcata120ttggcgatcctgttgtgctccctggcattgggcagtgttacagtgcactcttctgaacct180gaagtcagaattcctgagaataatcctgtgaagttgtcctgtgcctactcgggcttttct240tctccccgtgtggagtggaagtttgaccaaggagacaccaccagactcgtttgctataat300aacaagatcacagcttcctatgaggaccgggtgaccttcttgccaactggtatcaccttc360aagtccgtgacacgggaagacactgggacatacacttgtatgg403<210>55<211>413<212>DNA<213>人<400>55tagcgtggtcgcggccgaggtacgactcggtgctcgccctgtccgcggccttgcaggcca60ctcgagccctaatggtggtctccctggtgctgggcttcctggccatgtttgtggccacga120tgggcatgaagtgcacgcgctgtgggggagacgacaaagtgaagaaggcccgtatagcca180tgggtggaggcataattttcatcgtggcaggtcttgccgccttggtagcttgctcctggt240atggccatcagattgtcacagacttttataaccctttgatccctaccaacattaagtatg300agtttggccctgccatctttattggctgggcagggtctgccctagtcatcctgggaggtg360cactgtctcctgttcctgtcctggggataagagcagggctgggtacctgcccg413<210>56<211>452<212>DNA<213>人<400>56ttcgagcggccgcccgggcaggttgaaactttagaaagaagagccgggaggatgtattgg60ttgttaggaaaatgtaggctaccagtagaaaatgacattctctattaataagatctgagg120tgcgacacacataattgtcccaatttttaagattgatggggagcatgaagcattttttta180atgtgttggcaggccccattaaatgcataaactgcataggactcatgtggtctgaatgta240ttttagggctttctgggaattgtcttgacagagaacctcagctggacaaagcagccttga300tctgagtgagctaactgacacaatgaaactgtcaggcatgtttctgctcctctctctggc360tcttttctgctttttaacaggtgtcttcagtcagggaggacaggttgactgtggtgagtc420caggacaccaaggcctactgcactcgggaacc452<210>57<211>190<212>DNA<213>大鼠<220><400>57ttcgcggcccngtcgacggcattggcaaatagtcaaacctgggaagtaaaaagcaaaacc60aaaaacaaaaccaaagaaacaaactaaaacaaaacaagaaaaaccaacatttcttcaatt120cagtgtgcaacatatataaaacagaaatactaactctacaggcagtatgtcgacgcggcc180gcgtattcgg190<210>58<211>413<212>DNA<213>小鼠<400>58ctgcaacaaggctgttggttcctctccaatgggctccagtgaagggctcctgggcctggg60ccctgggcccaatggtcacagtcacctgctgaagaccccactgggtggccagaaacgcag120tttttcccacctgctgccctcacctgagcccagcccagagggcagctacgtgggccagca180ctcccagggcctcggcggccactacgcggactcctacctgaagcggaagaggattttcta240aggggtcgacaccagagatgctccaagggcctgcaccaagttgcttttgggttttttctg300gtatttgtgttttctgggattttatttttattattttttttaatgtcctttctttgggta360atagagaaatctctgcaaaagactttgctgaccaaccagctggagctcaagga413<210>59<211>325<212>DNA<213>小鼠<220><221>不确定<222>(213)...(213)<221>不确定<222>(223)...(223)<221>不确定<222>(227)...(227)<221>不确定<222>(243)...(243)<400>59ggtatcacccaggcccacttatccatctacagcgagtagtatggcggccttccttgtaac60aggctttttcttttctctcttcgtggtgcttgggatggaacccagggctttgtttaggcc120tgacaaggctctgcccctgagctgtgccaagcccacctccctctgtgtacaaagctcctt180tcttgggtgaccaacatcttcctgtctttgagnaaccaggggncagnatgggagccaccc240agnagttaattaaaccaggttcatcgggagtttgctgaaatgttaagcatactctgttct300agagagggagtgaagaaaggggcca325<210>60<211>372<212>DNA<213>小鼠<400>60ggccagcaggaccgcggtcatgagcctctgcaggtgtcaacaaggctcaaggagcaggat60ggatctcgatgtggttaacatgtttgtgattgcgggtgggaccctggccattccaatcct120ggcatttgttgcgtctttcctcctgtggccttcagcactgataagaatctattattggta180ctggcggaggacactgggcatgcaagttcgctacgcacaccatgaggactatcagttctg240ttactccttccggggcaggccaggacacaagccatccatccttatgctccatggattctc300cgcacacaaaggacatgtggctcagcgtggccaagttccttcccgaaagaacctgcactt360tggctgtgtgga372<210>61<211>363<212>DNA<213>小鼠<220><221>不确定<222>(15)...(15)<400>61gggcgcgcaggcggnaccggtggcggcggggctgctgctggctaattggcacaggactgc60gggccgcgacatggactgtcctgtgcagcccgaattccagcctcgttgtagccaggcaca120ccaagagctttccaccaaagaagcccctccaagcactgaccatgtctattatggaccaca180gccccaccaccggggtggtaacggtcattgtcatcctcatcgccatagctgccctggggg240gcttgatcctgggctgctggtgctacctgcggctgcagcgcatcagccagtcagaggatg300aggagagcatcgtgggtgatggcgagacaaaggagcccttttactggtgcagtactctgc360taa363<210>62<211>399<212>DNA<213>小鼠<400>62aagggtcctgaagtcagttgttgcatcaaatacttcatttttggcttcaatgtcatattt60tggtttttgggaataacgtttcttggaatcggactgtgggcgtggaatgaaaaaggtgtc120ctctccaacatctcgtccatcaccgacctcggtggctttgacccagtgtggcttttcctc180tgagtggccagcccgagcctgagctctgtcaatgacatccaaggagaaaatgaggttaat240gagagacattaattaaacactccctcaccccaccgcaccaaaccagttgggttcttctga300tattctggaatactctgggctatgttttatgtttatttcttttttaatcggttgtatttt360ggtctttttttttcttcttctttttcttttgctcccaaa399<210>63<211>399<212>DNA<213>小鼠<220><400>63caaagcccactgtaggctccgctgaggtagcgattgctgtatttctggtcatctgcatca60tagtggtcttaaccatcctgggctactgtttcttcaagaaccaaagaaaggaattccaca120gtcccctgcaccacccacctcccacaccagccagctccactgtttccaccacagaggaca180cagagcacctggtctataatcacacaacccagcctctctgagcctgggactcttgccagt240cttaccaggtcctgcttgccaagacagaagctagaacctggaaaaacttggggaccagac300tcttcctacctctttcctgggcatacttacgctgtctcagaagacagatctctgggcctc360tcgcaggagtctcagctgcactcaggccagttcctgggg399<210>64<211>2481<212>DNA<213>大鼠<400>64gaactgtatctggatgggaaccagtttacactggtcccgaaggaactctccaactacaaa60catttaacacttatagacttaagtaacaacagaataagcaccctttccaaccaaagcttc120agcaacatgacccaacttctcaccttaattctcagttacaaccgtctgagatgtatccct180ccacggacctttgatggattgaaatctcttcgtttactgtctctacatggaaatgacatt240tctgtcgtgcctgaaggtgcctttggtgacctttcagccttgtcacacttagcaattgga300gccaaccctctttactgtgattgtaacatgcagtggttatccgactgggtgaagtcggaa360tataaggaacctggaattgcccgctgtgccggtcccggagaaatggcagataaattgtta420ctcacaactccctccaaaaattttacatgtcaaggtcctgtggatgttactattcaagcc480aagtgtaacccctgcttgtcaaatccatgtaaaaatgatggcacctgtaacaatgacccg540gtggatttttatcgatgcacctgcccatatggtttcaagggccaggactgtgatgtcccc600attcatgcctgtacaagtaatccatgtaaacatggaggaacttgccatttaaaaccaagg660agagaaacatggatttggtgtacttgtgctgatgggtttgaaggagaaagctgtgacatc720aatattgatgattgcgaagataatgattgtgaaaataattctacatgcgttgatggaatt780aacaactacacgtgtctttgcccaccggaatacacaggcgaactgtgtgaggaaaaactg840gacttctgtgcacaagacctgaatccctgccagcatgactccaagtgcatcctgacgcca900aagggattcaagtgtgactgcactccgggatacattggtgagcactgtgacatcgacttt960gatgactgccaagataacaagtgcaaaaacggtgctcattgcacagatgcagtgaacgga1020tacacatgtgtctgtcctgaaggctacagtggcttgttctgtgagttttctccacccatg1080gtcttccttcgcaccagcccctgtgataattttgattgtcagaatggagcccagtgtatc1140atcagggtgaatgaaccaatatgccagtgtttgcctggctacttgggagagaagtgtgag1200aaattggtcagtgtgtcaattttggtaaacaaagagtcctatcttcagattccttcagcc1260aaggttcgacctcagacaaacatcacacttcagattgccacagatgaagacagcggcatc1320ctcttgtacaagggtgacaaggaccacattgctgtggaatctatcgagggcattcgagcc1380agctatgacaccggctctcacccggcttctgccatttacagtgtggagacaatcaatgat1440ggaaacttccacattgtagagctactgaccctggattcgagtctttccctctctgtggat1500ggaggaagccctaaaatcatcaccaatttgtcaaaacaatctactctgaatttcgactct1560ccactttacgtaggaggtatgcctgggaaaaataacgtggcttcgctgcgccaggcccct1620gggcagaacggcaccagcttccatggctgtatccggaacctttacattaacagtgaactg1680caggacttccggaaagtgcctatgcaaaccggaattctgcctggctgtgaaccatgccac1740aagaaagtgtgtgcccatggcacatgccagcccagcagccaatcaggcttcacctgtgaa1800tgtgaggaagggtggatggggcccctctgtgaccagagaaccaatgatccctgtctcgga1860aacaaatgtgtacatgggacctgcttgcccatcaacgccttctcctacagctgcaagtgc1920ctggagggccacggcggggtcctctgtgatgaagaagaagatctgtttaaccccctgcca1980ggtgatcaagtgcaagcacgggaagtgcaggctctctgggctcgggcagccctattgtgg2040atgcagcagtggattcaccggggacagctgacacagagaatttcttgtcgaggggaacgg2100ataagggattattaccaaagcagcagggtacgctgcctgtcaaacgactagaagtatctc2160gcttggagtgcagaggcgggtgtgctggggggcagtgctgtggacctctgagaagcaaga2220ggcggaaatactctttcgaatgcacagatggatcttcatttgtggacgaggtcgagaagg2280tggtgaagtgcggctgcacgagatgtgcctcctaagtgcagctcgagaagcttctgtctt2340tggcgaaggttgtacacttcttgaccatgttggactaattcatgcttcataatggaaata2400tttgaaatatattgtaaaatacagaacagacttatttttattatgataataaagaattgt2460ctgcatttggaaaaaaaaaaa2481<210>65<211>3008<212>DNA<213>小鼠<220><400>65tagacgggagcctgtggctacaagccactcagcctgatgacgccggccactatacctgtg60ttcccagcaatggctttctgcatccaccgtcagcttctgcctatctcactgtgctctacc120cagcccaggtgacagtcatgcctcccgagacacccctgcccactggcatgcgtggggtga180tccggtgtccggttcgtgctaatcccccactactgtttgtcacctggaccaaagacggac240aggccttgcagctggacaagttccctggctggtccctgggcccagaaggttccctcatca300ttgcccttgggaatgaggatgccttgggagaatactcctgcaccccctacaacagtcttg360gtactgctggaccctcccctgtgacccgggtgctgctcaaggctcccccggcttttatag420accagcccaaggaagaatatttccaagaagtagggcgggagctactcatcccgtgctccg480cccggggagaccctcctcctattgtctcttgggccaaggtgggccgggggctgcagggcc540aggcccaggtggacagcaacaacagcctcgtccttcgacccctgaccaaggaggcccagg600gacgatgggaatgcagtgccagcaatgctgtagcccgtgtgaccacttccaccaatgtat660atgtgctaggcaccagcccccatgtcgtcaccaatgtgtctgtggtacctttacccaagg720gtgccaatgtctcttgggagcctggctttgatggtggctatctgcagagattcagtgtct780ggtataccccactagccaagcgtcctgaccgagcccaccatgactgggtatctctggctg840tgcctatcggggctacacacctcctagtgccagggctgcaggctcacgcgcagtatcagt900tcagtgtccttgctcagaataagctgggcagtgggcccttcagtgagattgtcctgtcta960taccagaagggcttcctaccacaccggctgcccctgggctgcctgcaaccaggagcagag1020tgtgagcctgacttcccacgtggagagaagatcagaggcggatcctggcgcagacgtttt1080cggtggcgtcgggcagccctgcgccgattcatcaggcaggcagctaggatgctcacaagg1140accgccacgcccaagaagcagactccacccacaacaccagccaatacaggctggggcagg1200agacctggtagctgtgtgcgggaggggtacacctccaggccggaagtggagatgttggct1260acgttgctggggtcactgacgtagctatcagcgaaggccacgaggcgaaactcatagaga1320acgtccttgatgaggccaggcaccagcagctggatttctgtgcccgccacaccttggtcc1380aggatctcccagccttgggagccttgccgtccctccaggatgtagccatccagcctccca1440gggatgagttctgggggatccctctgatcttctctccacgtgggaagtcaggctcacact1500ctgctcctggttcaggcagccctgacagcgtgaccaagttcaagctccaaggctccccag1560ttcccatcctacgccagagtctgctctggggggagcctgctcgaccgcctagccctcacc1620cggattctccacttggccggggacccttaccattagagcccatttgcaggggcccagatg1680ggcgctttgtgatgggacccactgtggccccctcacaagaaaagttatgtctggagcgcc1740cagaacctcggacctcagctaaacgcttggcccagtcctttgactgtagcagtagcagcc1800ccagtggggtcccacaacccctctgcattacagacatcagccccgtggggcagcctcttg1860cagccgtgcctagccccctaccaggtccaggacccctgctccagtatctgagcctaccct1920tcttccgagagatgaatgtggacggggactggccacctcttgaggagcccacgcctgctt1980cggcttcaaaattcatggatagtcaagccctgccccacctatctttccttccaccaccag2040actcacctcctgcaaatctcagggcaagtgcttcctgggacactgatgggggtcggggtc2100tcctcagagcccccttacacagctttggctgattggactctgagggagcgggtcttgccg2160ggccttctttctgctgcccctcgtggtagcctcaccagccagagcatgggaggggcaagc2220gcctccttcctgcgccctccctcacagccccctccgcaggggaagctacctcagtccact2280ccaggagacacaaagcagctggggccagtggcccccgaaaggtggccccgcaagggaaca2340tgtggtgacagtcacaaaaaggaggaaccacctctgtggatgagaactatgaatgggatt2400cggaattcccaggggacatggagctgctagagacctggcacccaggcttggccagttctc2460ggacccatcctgaacttgagccagagttaggtgtcaagactccagaggagagctgtctcc2520tgaacccaacccacgctgccggccccgaggcccgctgtgctgcccttcgggaggaattcc2580tagctttccgcagacgcagggatgctaccagggcccggctaccagcctatcagcagtcca2640tctcttaccctgaacaggctactctgctatgagcccgcttagtgtgaaactaagaaaggc2700ttatatggatttgcaaaggagtccaagactttggctccaagctggggtactgcccctacc2760tctctgtgtctcggtggcctggtggtaggcttgagtgagcttggtatagagttggatgta2820ctgactctttaattgagtttgggagctgaacaggaatgtgtgtgtgtgtgtgtgtgtgtg2880tgtgtgtgtgtgtgtgcgcgcgcaagcgcaagcgcgagttcgaaagtggtgtttatggtg2940tgggtgcaggttttttttttttaaaaaacaggtggataataaatgtttggaaccgttaaa3000aaaaaaaa3008<210>66<211>1888<212>DNA<213>小鼠<220><221>不确定<222>(1690)...(1690)<221>不确定<222>(1755)...(1755)<221>不确定<222>(1864)...(1864)<400>66aaagtggagggcgagggccggggccggtgggctctggggctgctgcgcaccttcgacgcc60ggcgaattcgcaggctgggagaaggtgggctcgggcggcttcgggcaggtgtacaaggtg120cgccatgtgcactggaagacgtggctcgcgatcaagtgctcgcccagtctgcacgtcgac180gacagggaacgaatggagctcctggaggaagctaagaagatggagatggccaagttccga240tacattctacctgtgtacggcatatgccaggaacctgtcggcttggtcatggagtacatg300gagacaggctccctggagaagctgctggcctcagagccattgccttgggacctgcgcttt360cgcatcgtgcacgagacagccgtgggcatgaacttcctgcattgcatgtctccgccactg420ctgcacctagacctgaagccagcgaacatcttgctggatgcccactaccaaatgtcaaga480tttcttgactttgggctggccaagtgcaatggcatgtcccactctcatgacctcagcatg540gatggcctgtttggtacaatcggctacctccctccagagcgaattcgtgagaagagccgc600ttgtttgacaccaaacatgatgtatacagcttcgccattgtgatctggggtgtgcttaca660cagaataatccatttgcagatgaaaagaacatcctacacatcatgatgaaagtggtaaag720ggccaccgcccagagctgccacccatctgcagaccccggccgcgtgcctgtgccagcctg780atagggctcatgcaacggtgctggcatgcagacccacaggtgcggcccaccttccaagaa840attacctctgaaacagaagacctttgtgagaagcctgatgaggaggtgaaagacctggct900catgagccaggcgagaaaagctctctagagtccaagagtgaggccaggcccgagtcctca960cgcctcaagcgcgcctctgctccccccttcgataacgactgcagtctctccgagttgctg1020tcacagttggactctgggatcttcccaagactcttgaaaggccccgaagagctcagccga1080agttcctctgaatgcaagctcccatcgtccagcagtggcaagaggctctcgggggtgtcc1140tcagtggactcagccttttcctccagaggatcgctgtcactgtcttttgagcgggaagct1200tcaacaggcgacctgggccccacagacatccagaagaagaagctagtggatgccatcata1260tcaggggacaccagcaggctgatgaagatcctacagccccaagatgtggacttggttcta1320gacagcagtgccagcctgctgcacctggctgtggaggccggacaggaggagtgtgtcaag1380tggctgctgcttaacaatgccaaccccaacctgaccaacaggaagggctctacaccactg1440catatggctgtggagcggaagggacgtggaattgtggagctactgctagcccggaagacc1500agtgtcaatgccaaggatgaagaccagtggactgccctgcactttgcagcccaaaatggg1560gatgaaggccagcacaaggctgctgctagagaagaatgcttctgtcaatgaggtggactt1620tgagggccgaacacccatgcatgtagcctgccagcatggacaggagaacattgtgcgcac1680cctgctccgncgtggtgtggatgtgggcctgcagggaaaggatgcctggttgcctctgca1740ctatgctgcctgcanggccaccttcccattgttaagctgctagccaagcagcctggggtg1800agtgtgaatgcccagacactaacgggaggacaccctgacctgctgttcaaaggggcattt1860accngtggctcgcattctcattgacctg1888<210>67<211>1260<212>DNA<213>大鼠<400>67gtcgctttgggtatcagatggatgaaggcaaccagtgtgtggatgtggacgagt60gtgcgacagattcacaccagtgcaaccctacccagatctgtatcaacacggaaggagggt120acacctgctcctgcactgatgggtactggcttctggaagggcagtgcctagatattgatg180aatgtcgctatggttactgccagcagctctgtgcgaatgttcctggatcctattcctgta240cgtgtaaccctggcttcaccctcaacgatgatggaaggtcttgccaagatgtgaacgagt300gtgaaactgagaacccctgtgttcagacctgcgtcaacacctatggttctttcatctgcc360gctgtgacccaggatatgaactggaggaagatggcattcactgcagtgatatggatgagt420gcagcttctccgagttcctctgtcaacatgagtgtgtgaaccagccgggctcatacttct480gctcatgccctccaggctacgtcttgttggaagataaccgaagctgccaggatatcaatg540aatgtgagcaccggaaccacacatgcactcccctgcagacttgctacaatctgcaagggg600gcttcaaatgtatcgaccccatcgtctgcgaggagccttatctgctgattggggataacc660gctgtatgtgccctgctgagaatactggctgcagggaccagccattcaccatcttgtttc720gggacatggatgtggtatcaggacgctctgttcctgctgacatcttccagatgcaagcaa780cgacccgataccctggcgcctattacattttccagatcaaatctgggaacgagggtcgag840agttctacatgcggcaaacagggcctatcagtgccaccctggtgatgacacgccccatca900aagggcctcgggacatccagctggacttggagatgatcaccgtcaacactgtcatcaact960tcagaggcagctccgtgatccgactgcggatatacgtgtcccagtatccgttctgagcct1020cgggttaaggcctctgacactgccttttaccacgccgagggacaggaggagagaagaacc1080ccaacgagggacaggaggagagaagaaaccagcaagaatgagagcgagacagacattgca1140cctttcctgctgaacatctccctggggcatcagcctagcatcctgacccctacctgtact1200atcgcaaactgtcactctgaaggacaccatgccccagttcctatgatgcagtagtatcca1260<210>68<211>1729<212>DNA<213>小鼠<400>68gaattcggcacgagcagaatatggctctgggggttctgatagcagtctgcctcttgttca60aagcaatgaaggcagcactgagcgaagaagcagaggtgatccctcctagcacagcacagc120agagcaactggacatttaacaacaccgaagctgactacatagaagaacctgtagctctga180agttctctcatccttgtctggaagaccataatagttactgcattaatggagcatgtgcat240tccaccatgagctgaagcaagccatttgcagatgctttactggttatacgggacaacgat300gtgagcatttgaccctaacttcgtatgctgtggattcttatgaaaaatacattgcgattg360ggattggcgtcggattgctaattagtgcttttcttgctgtcttctattgctacataagaa420aaaggtgtataaatctgaaatcaccctacatcatctgctctggagggagcccattgtgag480accttataagacatagtcatcaagccatttgtcaaaagccacagggaatccaatggagat540ctttggatgatacaaaatgtgataagctaacttgaaaataatggtggtttgggtcacaat600gcagtaactgaccattggttcttagctttggtcatcgttgggtgccatggaagctatggg660aatgagctacagtaacagaagccaagttcactacccttctttgggtttgctgttgggtgg720ttgttgtcactgcaggaagatttgttctatacttctgaccatctcagatgtgaattttca780ttttaattgttttctactacacatcaatcaagtccaagtaatgccatttccgggttcttc840gggcactcaacattttgggccacccgcctcgatggacctaatagcaaagtatctgtcctt900atggaatttcagggaatttggtatcaatttttagatgaaaacagtgaatgtctcagctcc960ttgagtgaaccaaagatgcattacacctaaaccactaaaagaaaatggaatatccaaggc1020agcataaatcctacccagctggtgacaacagtttgcaaacttcattcatgtagtttggaa1080gaagcagataaattcctgaggactgaaagtcacctggacagcagatccagagcaggcaaa1140ggtagctggttcctatatcgaccataaagcctgtgtgggctcatctgtcccctgatgttt1200ttgcctatcatctcagccttacattggaagactcacacttggtatccatcgcttgaactg1260aagttcgacaattcacctaatgactaaaagcttacaattgttcccaaaatatataggaac1320aacagcatgtggaatgtaaccattttttgacgtgttgatagcatatttgcacatgggtta1380aaaaaagaaacagtcgtagaaatacttattagggaatcagtatccctccttggaattgct1440tctgctacatgattcaatcttgggcaagtctcttatattctttgtggtttggttccattc1500tctacaagacccatgcagttccaaaattgaactctaatagaactaaaaaatacctcctat1560aactgcatggcaggcaagattatcctcaatgcttccatcctcagccccgtttctaaccct1620caaatacccacgaatattatccttactatatattgtcatgttcagtttgtaaaataataa1680cttattttgaaaagaaataaaaaatgaaattacaaagcaaaaaaaaaaa1729<210>69<211>355<212>DNA<213>大鼠<400>69ctcgtgccgcaattcggcacgaggattcgctatactgcatatgaccgagcctacaaccgg60gccagctgcaagttcattgtaaaagtacaagtgagacgctgtcctattctgaaaccacca120cagcatggctacctcacctgcagctcagcgggggacaactatggtgcgatctgtgaatac180cactgcgatggtggttatgaacgccaagggaccccttcccgagtctgtcagtcaagtcga240cagtggtctggatcaccacctgtctgtactcctatgaagattaatgtcaatgttaactca300gctgctggcctcctggatcagttctatgagaaacagcgactcctcatagtctcag355<210>70<211>1421<212>DNA<213>人<400>70gattagcgtggtcgcggccgaggtgtctgttcccaggagtccttcggcggctgttgtgtc60agtggcctgatcgcgatggggacaaaggcgcaagtcgagaggaaactgttgtgtctcttc120atattggcgatcctgttgtgctccctggcattgggcagtgttacagtgcactcttctgaa180cctgaagtcagaattcctgagaataatcctgtgaagttgtcctgtgcctactcgggcttt240tcttctccccgtgtggagtggaagtttgaccaaggagacaccaccagactcgtttgctat300aataacaagatcacagcttcctatgaggaccgggtgaccttcttgccaactggtatcacc360ttcaagtccgtgacacgggaagacactgggacatacacttgtatggtctctgaggaaggc420ggcaacagctatggggaggtcaaggtcaagctcatcgtgcttgtgcctccatccaagcct480acagttaacatcccctcctctgccaccattgggaaccgggcagtgctgacatgctcagaa540caagatggttccccaccttctgaatacacctggttcaaagatgggatagtgatgcctacg600aatcccaaaagcacccgtgccttcagcaactcttcctatgtcctgaatcccacaacagga660gagctggtctttgatcccctgtcagcctctgatactggagaatacagctgtgaggcacgg720aatgggtatgggacacccatgacttcaaatgctgtgcgcatggaagctgtggagcggaat780gtgggggtcatcgtggcagccgtccttgtaaccmtgattctcctgggaatcttggttttt840ggcatctggtttgcctatagccgaggccactttgacagaacaaagaaagggacttcgagt900aagaaggtgatttacagccagcctagtgcccgaagtgaargagaattcaaacagacctcg960tcattcctggtgtgagcctggtcggctcaccgcctatcatctgcatttgccttactcagg1020tgctaccggactctggcccctgatgtctgkagtttmacaggatgccttatttgtctttta1080caccccacagggccccctacttcttcggatgtgtttttaataatgtcagctatgtgcccc1140atcctccttcatgccctccctccctttcctaccactgmtgagtggcctggaacttgttta1200aagtgtttattccccatttctttgagggatcaggaaggaatcctgggtatgccattgact1260tcccttctaagtagacagcaaaaatggcgggggtcgcaggaatmtacactcaactgccca1320cctggctggcagggatctttgaataggtatcttgagcttggttctgggctctttccttgt1380gtacctgcccgggcggccgctcgaaatcaagcttatcgata1421<210>71<211>378<212>DNA<213>人<400>71tagcgtggtcgcggccgaggtacaaaaaaaccttacataaattaagaatgaatacattta60caggcgtaaatgcaaaccgcttccaactcaaagcaagtaacagcccacggtgttctggcc120aaagacatcagctaagaaaggaaactgggtcctacggcttggactttccaaccctgacag180acccgcaagacaaaacaactggttcttgccagcctctagagaaatcccagaacactcagc240cctgacacgttaataccctgcacagatcagaggctgctggccacacagactcaccaagcc300acagacttgtcttccacaagcacgttcttaccttagccacgaagtgacccaagccacacg360tacctgcccgggcggccg378<210>72<211>267<212>DNA<213>小鼠<400>72ggggcatgggccatgctgtatggagtctcgatgctctgtgtgctggacctaggtcagccg60agtgtagttgaggagcctggctgtggccctggcaaggttcagaacggaagtggcaacaac120actcgctgctgcagcctgtatgctccaggcaaggaggactgtccaaaagaaaggtgcata180tgtgtcacacctgagtaccactgtggagaccctcagtgcaagatctgcaagcactacccc240tgccaaccaggccaaagggtggaagtc267<210>73<211>1633<212>DNA<213>小鼠<220><400>73ggcacgagcgggagcctgctactgccctgctgggttccttggggccgactgtagccttgc60ctgtccacagggtcgcttcggccccagctgtgcccacgtgtgtacatgcgggcaaggggc120ggcatgtgacccagtgtcggggacttgcatctgtcctcccgggaagacgggaggccattg180tgagcgcggctgtccccaggaccggtttggcaagggctgtgaacacaagtgtgcctgcag240gaatgggggcctgtgtcatgctaccaatggcagctgctcctgccccctgggctggatggg300gccacactgtgagcacgcctgccctgctgggcgctatggtgctgcctgcctcctggagtg360ttcctgtcagaacaatggcagctgtgagcccacctccggcgcttgcctctgtggccctgg420cttctatggtcaagcttgtgaagacacctgccctgccggcttccatggatctggttgcca480gagagtttgcgagtgtcaacagggcgctccctgtgaccctgtcagtggccggtgcctctg540ccctgctggcttccgtggccagttctgcgagagggggtgcaagccaggcttttttggaga600tggctgcctgcagcagtgtaactgccccacgggtgtgccctgtgatcccatcagcggcct660ctgcctttgcccaccagggcgcgcaggaaccacatgtgacctagattgcagaagaggccg720ctttgggccgggctgtgccctgcgctgtgattgtgggggtggggctgactgcgaccccat780cagtgggcagtgccactgtgtggacagctacacgggacccacttgccgggaagtgcccac840acagctgtcctctatcagaccagcaccccagcactccagcagcaaggccatgaagcacta900actcagaggaacgcccacagaggcccactactgtgttccagcccaagggacccaggcctc960tgctggtgactaagatagaggtggcacttttggatccacacctcttctggaaagccatgg1020attgctgtggacagctatggatagtcatatagccacacacccgggctccatggtcatggg1080gaagaaggcctcctttggacacaaggaatccaggaagtcggctgggcttcgggccactgt1140ttacatggggaccctgcaggctgtgctgtggaatcctggccctcttcagcgacctgggat1200gggaccaaggtgggaatagacaaggccccacctgcctgccaggtccttctggtgctaggc1260catggactgctgcagccagccaactgtttacctggaaatgtagtccagaccatatttata1320taaggtatttatgggcatctccacctgccgttatggtcctgggtcagatggaagctgcct1380gaccccagaacttaggcagtggcctgtggggtctccagcaagtgggatcaagggttttgt1440aaaacccagtgagttaaaggcacagtggtgtccccattgcctgggtttctgtgctttctg1500tagactccgtgggtccttccaagagcaggtggcctgagggttcttgaatgggaacctcctgt1560acccctctgtaatgacatgcatgtaatgtaatgcttcagtcaccttagggttcttcctga1620cttccagctctag1633<210>74<211>1252<212>DNA<213>小鼠<400>74ggaagagccgtgcaataatgggtctgaaatccttgcttataacatcgatctgggagacag60ctgcattactgtgggcaacactaccacacacgtgatgaagaacctccttccagaaacgac120ataccggatcagaattcaggctatcaatgaaattggagttggaccatttagtcagttcat180taaagcaaaaactcggccattaccgccttcgcctcctaggcttgagtgtgctgcgtctgg240tcctcagagcctgaagctcaagtggggagacagtaactccaagacacatgctgctggtga300catggtgtacacactacagctggaagacaggaacaagaggtttatctcaatctaccgagg360acccagccacacctacaaggtccagagactgacagagtttacctgctactccttcaggat420ccaggcaatgagcgaggcaggggaggggccttactcagaaacctacaccttcagcacaac480caaaagcgtgcctcccaccctcaaagcacctcgagtgacgcagttagaagggaattcctg540tgaaatcttctgggagacggtaccaccgatgagaggcgaccctgtgagctacgttctaca600ggtgctggttggaagagactctgagtacaagcaggtgtacaagggagaagaagccacatt660ccaaatctcaggcctccagagcaacacagattacaggttccgcgtgtgtgcctgccgccg720ctgtgtggacacgtctcaggagctcagtggcgcgttcagcccctctgcggctttcatgtt780acaacagcgtgaggttatgcttacaggggacctgggaggcatggaagaagccaagatgaa840gggcatgatgcccaccgacgaacagtttgctgcactcatcgtgcttggcttcgcgaccct900gtccattttgtttgcctttatattacagtacttcttaatgaagtaaatccagcaggccag960tggtatgctcggaacgccacacgttttaatacacatttactcagagcctcccctttttac1020gctgtttcgttctttgatttatacgcttctcttgttttacacatttagctaggggaaaga1080gtttggctgcacctatttgagatgcaaaactaggaagaggttaaactggattttttttta1140aacaataataaataaaggaataaagaagagaaggaagcggcgggcaagctccagacaccg1200agagccagtgtgcccaacgagcttgccttgtcgggcttcccgtgtgcttctg1252<210>75<211>2411<212>DNA<213>小鼠<400>75tcggcacgagagtgggtacaccttactacatgtctccagagagaatacatgaaaatggat60acaacttcaagtctgacatctggtctcttggctgtctgctatatgagatggctgcactgc120agagtcctttctacggcgacaagatgaacttgtattctctgtgtaagaagatagagcagt180gtgactacccgcctctcccgtcagatcactattcggaggagctacgacagctagttaata240tatgcatcaacccagatccagagaagcgacccgacatcgcctatgtttatgatgtggcaa300agaggatgcatgcatgtaccgcaagcacctaaactgtacaagatcctgaagacggcaacc360aagataacttaaaagtgtttttgtgcagatcatacctccccgcttatgtctgggtgttaa420gattactgtctcagagctaatgcgctttgaatccttaaccagttttcatatgagcttcat480ttttctaccaggctcaatcaccttcccaatccacaactttgggatgctcagatggcacca540agaatgcaagcccaacaagagtttttcgtttgagaattgtttcgagtttctgctgataga600ctgtgtttatagatagtcagtgcccgatggtgaagcacacacacataggcacatgtccag660agcgatgcagaacctgaggaaggacctgggcatttgacttgtttgcttttaagtcactta720atggacgttgtagtggacatgattgtgaacttctgatttttttcttttaagtttcaagta780catgttttagttcttagcattagagatctcaaatataattcttataagacatgcagacat840aaactttttgagaaagatttaaaatttttagtttatacattcaaaatgcaactattaaat900gtgaaagcatagaggtcaaaatgtgagttggacactgaagtctatgttttaatgcctttg960aaagcctttttttgtgtgtgtttaaatggtataaatgaacccattttaaaacgtggttaa1020ggacttgtttgcctggcgtgatagtcatgtttaacatgcacaaggctttgtgtttttatt1080gtacatttgaagaatattcttggaataatcttgcagtagttatagttcaatttctttaca1140aatctaaatacacttaactcataactatacactgtaatgcaagcatatattgttattcat1200atattgaagttttgatcagttcctcttcagaatcttttttatccaagttactttcttatt1260tatattgtgtgtgcatttcatccattaaatgtttcagattttctgagaatgagttccctt1320tttaaaatatatttggtatgccaacacttttttaggattgaaaaaaaatttttttaaatg1380tttgggtcattctaggtgcatctgttttctcttgttagaaagaaaaggtgtgtgttaaaa1440tgtgcctgtgaatgtcgatattgtttggcagggttataattttagagtatgctctagagt1500atgttgaacagcgtgaagactggcccttactgaagacagaactgttccaagagcagcatt1560cccgttgagatgctttggagtaaagtactgtgtatgacgatgacagacattttagttaag1620ggggtgaaaaaaaaaggaggggtatttaggaaaccctgaggtggaattttggtgaatgtc1680ttcatcttaataccagccaattccttcagagaattgtggagccaaagaacagagtaatcg1740tggctgttgcagaacacggtgtgccatggtagagcattgggaaggctcatcctgccggtg1800ggtcggtcagacagccctgtgttggggagcttgtactctggcccacagagctcggttgat1860tttcttacagagtattctttctacagttattttcaagtaattgtaaattttcaaagtaat1920atctcatcttttaattcactatgtatgctgtcgtagacaaaggaaatctgggtttttttt1980tgtttttgtttttgtttttttttgtcttgaaggctgaactgggtacatcccagatcttag2040tggctcataggatatacccagaggcatgaagaaatggcttccggtgaccatttgtgttgk2100gktatatcccattgtaatgtcacaggactgattgagatgaaacatccccttcctacaaga2160gttgttttctttccatatttaaaaacatgaggttctgcctggcagtgatggtacacacct2220ttaatcccagcacccgggaggcagaggcaggaggatttctgagttcgaggccagcctggt2280ctacaaagtgagttccaggacagccaggactacacagagaaatcctgtctcaaaaaacca2340aaactaaatgaaaatacaaggcttctccccttgtagtgactttgctttatgaatttgtct2400caaaaaaaaaa2411<210>76<211>1335<212>DNA<213>小鼠<400>76acccaaacagcccgggaccatgctgtcgctccgctccttgcttccacacctgggactgtt60cctgtgcctggctctgcacttatccccctccctctctgccagtgataatgggtcctgcgt120ggtccttgataacatctacacctccgacatcttggaaatcagcactatggctaacgtctc180tggtggggatgtaacctatacagtgacggtccccgtgaacgattcagtcagtgccgtgat240cctgaaagcagtgaaggaggacgacagcccagtgggcacctggagtggaacatatgagaa300gtgcaacgacagcagtgtctactataacttgacatcccaaagccagtcggtcttccagac360aaactggacagttcctacttccgaggatgtgactaaagtcaacctgcaggtcctcatcgt420cgtcaatcgcacagcctcaaagtcatccgtgaaaatggaacaagtacaaccctcagcctc480aacccctattcctgagagttctgagaccagccagaccataaacacgactccaactgtgaa540cacagccaagactacagccaaggacacagccaacaccacagccgtgaccacagccaatac600cacagccaataccacagccgtgaccacagccaagaccacagccaaaagcctggccatccg660cactctcggcagccccctggcaggtgccctccatatcctgcttgtttttctcattagtaa720actcctcttytaaagaaaactggggaagcagatctccaacctccaggtcatcctcccgag780ctcatttcaggccagtgcttaaacatacccgaatgaaggttttatgtcctcagtccgcag840ctccaccaccttggaccacagacctgcaacactagtgcacttgagggatacaaatgcttg900cctggatctttcagggcacaaattccgcttcttgtaaatacttagtccatccatcctgcg960tgtaacctgaagttctgactctcagtttaacctgttgacagccaatctgaacttgtgttt1020cttgccaaaggtattcccatgagcctcctgggtgtgggggtggggagggaatgatccttc1080tttactttcaaactgatttcagatttctggccaaacctactcaggttgcaaaggacttat1140gtgacttatgtgactgtaggaaaaagagaaatgagtgatcatcctgtggctactagcaga1200tttccactgtgcccagaccagtcggtaggttttgaaggaagtatatgaaaactgtgcctc1260agaagccaatgacaggacacatgactttttttttctaagtcaaataaacaatatattgaa1320caaggaaaaaaaaaa1335<210>77<211>440<212>DNA<213>小鼠<220><400>77gagaagccttgcccactcaaatacctgggc60catcagctgcaccggctccactcccatctgctccaggccctgaagagaagccaacacttt120tcaggcccctcaacctccacatcagaacaggcagagcctgtggtgtcagctgttgatcca180aaggcaacccttggtggggttggggttgtaaagtagtgatgctaatttctaagcaacaag240ctctgagctgcagcccccaggccctccagggcagtccagggcagtgccagggttcagggt300agttctaggggtctagtatctggatcaacaagtcccagagttgggcccagtggctgctga360cttgttcaatgaccaagaatatacgacctaaccttttttatttggttgggcaaccacagc420tccgagtaagtcatcaaggc440<210>78<211>204<212>DNA<213>小鼠<400>78ctccataaaattcctcaaaatctgttcccccagcagatttcctgtgccatcttgggctcc60cttcctattctttcccgtctttagggcctcctcacagtgttgttttctaacaacgcaggc120atgagaaggcactcactgtgtgctccctcaggcctggcctctcctggtgattgtcttctt180cctctgtgtcctcttcatcccaat204<210>79<211>300<212>DNA<213>小鼠<220><400>79tatttatgacttgggttaagggagtttgctgtgcaatcatgaagaccagagttcagatcc60cagcacccatatagcaagagagcatacaagaagcacctgtgactgcactctgaagaatcc120aacaccttcttctggcctccatggcacacagaaccccccaacacatgctcatccactctc180aaagagacatacataaaaataaatatttaggtcctgggtccctcagagactagtcttcac240aggtcctaaatacaaacgagcggaccgcaaagggtgagggagtggatgaagaagcta300<210>80<211>214<212>DNA<213>小鼠<400>80cccagaccctgtgtcagctatcccagcagaaaaagaagatgcggaccctctcagcaagtc60aggtgaggaaacccaggaagcagggtcatgaccccgcagaggtcggggctcctggtgcag120aggatcagatcttgtgtgacttctgtcttggggccagcagagtaagggcagtgaaatcct180gtctgacctgcatggtgaaatactgtaaggagca214<210>81<211>152<212>DNA<213>小鼠<220><400>81ccccttaactaacccaggaccttccactaagtggaaggctccaccatccacagagggggc60cagtcatttttaagcacacggaccttttgtgagacagtcgtgatcttaactgtggtgtca120ctgatggagctgaacggtatcccctaaaagta152<210>82<211>181<212>DNA<213>小鼠<220><400>82tctcagtgatgatgagaagctccggaggaggcaggagaaagcagggccccgcccctccct60gggtctccacccacccacgcccgctaaggtcacctgttctcccatggagatgatgaagaa120gctcatagctggacaaggcccggaacctcagcccagtaaccgacctacttcccgcctggg180a181<210>83<211>332<212>DNA<213>小鼠<220><400>83tatagagatggtgatgtaatgggccagggtgtaagcttcaacctgggggattttgctggt60tttgttgtttccctgtgtagccctaacaagcctgtgtagaccaggctggctttaactttg120cagatgacattcacgtctacttctctctgtgttggggttatgggtctgcacacctgccca180ggcctaggctgggggattttgaagtatcttagattatggagtagacccagagtttgcaag240tatctgctttaaagtgacacataaacatagcctcctgaccatcttccacagtgggaccct300gatctggcctctccctggaagaagagagaaag332<210>84<211>213<212>DNA<213>小鼠<400>84gcaggcagataacaatgattactggacagagtgcttcaacgcattggaacaggggaggca60atatgtggataatcccacaggcgggaaagtggacgaggctctggtgagaagtgccaccgt120acattgttggccgcacagcaacgtgctggacacaagcatgctctcatccccagatgtggt180gcgcatgctgctgtccctgcagcccttcctgca213<210>85<211>273<212>DNA<213>小鼠<220><400>85ccggctctctctctcctccttccccgcctcttctgcctcccctgcctggaactctgatga60ggagggaccaggtggtcaggcaccccagtctgatcaggactcctgtggcctccagagttt120cactcccccgtccatcctgaagcgggctcctcgggagcgtccaggtcacgtggcctttaa180cggcatcaccgtctactatttcccacggtgccagggattcaccagtgtgcccagccgtg240gtggctgtaccctgggcatggcttctcggcaca273<210>86<211>218<212>DNA<213>小鼠<400>86ctcagccgcctgctctgggggctggagggtctcccacttaactgtgtctgccgttcaggg60ggctcacccagtgctgcgctacacagaggttttccctccagctccagtccgtcctgccta120ctccttctataaccgcctccaagagctggcctcactgttgccccggccggataagccctg180cccagcctatgtggagcctatgactgtggtttgtcacc218<210>87<211>335<212>DNA<213>小鼠<400>87gaggtggggtgggtgcatagcctgcctgcaattgctgccgctgggcttaacgtgttgtga60gctggccggtttcctacacagcagcacctgccatggagcctggccacaaggccactcaga120gctgggtggacagagtgtgaccagaaactccctgtgggttctgataaaggattctcccat180aggcaaggttcagagaacctgggcctcctgttctcagggaggcctgtctatccccagcct240ctgagctgtttcgtcctagttggtgagttaagtggcatagccctcttgaggcctctgatg300tggaaggggcacagaattgcaattattcttgcatg335<210>88<211>410<212>DNA<213>小鼠<400>88aaaccccgccaggaaacaaataccggtgtatcggctttactgaatgcatttattcccaaa60gggaaactgaaaagcaacctagggacactgtaagcagaaagctgaggcttttaaaaaccc120accttggcaatgtaacttgggaggttcccacacacccagggctgtgcatcgtgaaattct180gtctcctgagacgctgagaaacccttccttgcagctataatgggcctggccgcccagtgt240ggagctgtagcttcccacgacgtagccctcaggaacttcaggagggatgccacagtctat300ttctgaaaacaaaaccgtgtcaacttctttactttacaaatgcaagttttcagaatccac360catctctctgcacccataccccatgcctcacaccccagaccctgtgttag410<210>89<211>279<212>DNA<213>小鼠<220><400>89gtgcagagagtggattgtcagtggactgctcagttacaaatgggacatctaacacacaca60cacacacacacacacacacacacacacacacaccccaaggcttagagaccattgcagaag120agaagagtttatgggaaatcttggagaaaacattggatggtttgagagaatggttaggag180atcagactagctagtccaggaagcagtgaaggggggcggggttagaagatgaggtcagaa240gacagggtggagggcattgtccgacagaaccattgctgt279<210>90<211>398<212>DNA<213>小鼠<400>90ccaccaacccagaaatttgacaaaggggttgaatgttggactttgcgtccttccccggca60gtggatgtactgttttgagccctgtgtggaacttctgaacttcgtgctgtaactttcaga120actcttagacatgggtgtgctcactgaactctagggtctgtgtgctagatgctgccaacg180ctgtattcaggacctgaagtgagtacccgtgtggatccagaccaatccagtgtgagacta240ctgaagaacatctgttgccagaacggccacaccaaacagatggagtgccccagcacttag300cttcttaaataacatcggaaccattcagccagcgagtctgtgtttgctttttgttaaatt360gtccgccgaatctaaattcctccaaaaggcttgtgacc398<210>91<211>279<212>DNA<213>小鼠<400>91gttgttacttcagttgctctcggcgggaattcttaaactgcatcctgagtgagggagctt60tggcgagaaagcaagacccagtggtagacagattagcattactgtacagcttctttgggt120gttcgaggaagcccggctggaccatagtggccacggcggtgaggtaggcgtggacagggc180tgaccagtccaagttaaggacgttcgggtccatgttaaccctgccttgtacgtccagcat240cgtaagaaaaaacacttgagaacccgaagaggagatgga279<210>92<211>401<212>DNA<213>小鼠<400>92aaaaagttttaccaaaaccttttattgacttttataaattagatagtatttcaaagttta60tgtagaatcgtattctttgaaactgtacttagcagagcagaagaggcctgctgacgctag120cacgctctgcaatgaatcatgtggcaccgagtctacgccaaggcccccgagaaactttat180tccatagatgggcagatggttcccaaagttacactacagaactacaaatcgactcttaaa240attaaaacgggactttacaagcattctagaagactcaaacttgaagcaatttttggaaaa300taaatgtacagagaaaagatcttgaagctactgaacagagaaccctcattaaccgagcaa360atacatcctatggagcttccgaggagtacacagacagaccg401<210>93<211>339<212>DNA<213>小鼠<400>93ccactgaccttcccagaaggtgacagccggcggcggatgttgtcaaggagccgagatagt60ccagcagtgcctcggtacccagaagacgggctgtctccccccaaaagacggcgacattcg120atgagaagtcaccacagtgatctcacattttgcgagattatcctgatggagatggagtcc180catgatgcagcctggcctttcctagagcctgtgaaccctcgcttggtgagtggataccga240cgtgtcatcaagaaccctatggatttttccaccatgcgagaacgcctgctccgtggaggg300tacactagctcagaagagtttgcagctgatgctctgctg339<210>94<211>55<212>DNA<213>小鼠<400>94ggggtgtgggcaacttggataacctcagctgcttccatctggctgacatctttgg55<210>95<211>186<212>DNA<213>小鼠<400>95ggactctggcttcctggggctgcggccgacctcggtggatcccgctctgaggcggcggcg60gcggggccccagaaacaagaagcgcggctggaggaggctcgccgaggagccgctggggtt120agaggtcgaccagttcctggaagacgtccggctacaggagcgcacgaccggtggcttgtt180ggcaga186<210>96<211>244<212>DNA<213>小鼠<400>96ggtgaccaaaaccccttctgcccccttcccagagactctgacttgaccctctttccaatt60ccctctccccaaggccatggattatgaagcccctctgtaagatggtgagccaggggccct120aagagggcatgaggcacaccctgatcactgtctcaggcctttgtgggcactgactcgacc180ctggcccacctcacgcccccaggccagttggcaactggtggctcttgagggctcttacgc240cctt244<210>97<211>116<212>DNA<213>小鼠<220><221>不确定<222>(11)...(11)<221>不确定<222>(13)...(13)<221>不确定<222>(41)...(41)<400>97acccggtctgngnactgcccgccttctggggcttcctttanaggatacagtcttttaccc60atctaggactcctgccaccctgactgctgacttacagctatgaggtcccggcttct116<210>98<211>307<212>DNA<213>小鼠<400>98ccccgggccatctgtcgccataccgggcccgtgcaagcttttgcaggttttagaagatgg60cgaattcatgacacctgtgatccaggacaacccctcaggctggggtccctgtgccgttcc120tgagcaatttcgggatatgccctaccagccattcagcaaaggagatcggctgggaaaggt180tgcagactggacaggggccacataccaggacaagaggtacacaaacaagtattcctctca240gttcggtggggggagtcagtatgcatatttccatgaggaggatgagacaagctttccagc300tgggtgg307<210>99<211>360<212>DNA<213>小鼠<220><400>99ccttggtgcaccagctccagcctcaggacttcctcctcctggccctgacagcccagctct60tgtcccagcagaatccagtgacaggaaggagtttctgaggcaggggaggaggcttctcca120tgggaaccagacagccttgcttcactgtataagtgccctgatcacacgcagaatgaagtg180ccaggttgctcagaagcacaaagggtgtggctactggccctaaccatggactacgtggtt240ctaaccaaagactctagaactctggggtgggggagaaacaatgtgttctgtgctccagaa300ctcggcttcctggcccatatggatgggcttggcaaggaacctacctcttctctaaggt360<210>100<211>257<212>DNA<213>小鼠<400>100tgccgcgctgagagggggggccgcaccaccagcgccaccaccaccaccgccgccgccgcc60gggtggggtgggaggggcgggagccaccgctaccgccgccgcctcccgggtgggcgccct120tctccttagacgccggcgacccaggacgagggcttcatcactgtaaatggttgcaagccg180acaaagctgcacctcctgaaaaagacggacagcccatcgcgtgagctgtagaaatttgtg240gacgcatttctatcggt257<210>101<211>203<212>DNA<213>小鼠<400>101ccaaagtgcccattgtgattcaagacgatagccttcccacggggccccctccacagatcc60gcatcctcaagaggcccaccagcaacggtgtggtcagcagccccaactccaccagcaggc120cagcccttcctgtcaagtccctagcacagcgggaggcagagtatgcagaggctcggagac180ggatcctaggcagtgccagccct203<210>102<211>300<212>DNA<213>小鼠<400>102agtacagagacctcggctgcagcttaaacctcggacagtggcaacgcccctcaatcaagt60agccaaccccaactcagccatctttgggggagccaggcccagagaggaagtggttcagaa120ggagcaagaatgagcttaggttgggagggaatggggcgtgggggagctggagcaagacca180cggcctggtggcagccggtcgccctacaggccccattcccgcctggcactgtcctcctta240cagcggaaacacagagcttgtgagtgcatgtcagctgttaacaagtggtttctagtacat300<210>103<211>370<212>DNA<213>小鼠<220><400>103cagcaactgtttcaggagctgcacggtgtacgcctgctgactgatgcgctggaactaaca60ctgggcgtggcccccaaagaaaaccctccggtgatgcttccagcccaagagacggagagg120gccatggagatcctcaaagtgctctttaatatcacctttgactctgtcaagagggaagtt180gatgaggaagatgctgccctttaccggtacctggggactcttctgcggcactgcgtgatg240gttgaagctgctggggaccgcacagaggagttccacggccacacggtgaatctcctgggg300aacttgcccctcaagtgtttggatgtgcttctggccctggagctccacgaaggatcctta360gagtcaatgg370<210>104<211>423<212>DNA<213>小鼠<400>104tttcccagcctggtggagcagccgactggcgagtgtgccaactgtcccgtgcttcccagc60tcctaccttgcctgtcttctctctcctgggaagatgttcctggtggggctgacgggaggc120atcgcctcaggcaagagctccgtcatccaggtattccaacagctgggctgtgctgtaatc180gacgtggacgtcattgcgcggcacgttgtccagccagggtatcctgcccaccggcgtata240gtagaggcctttggcactgaagtcttgctggagaatggcgacatcgaccgcaaggtcctc300ggagacctgatcttcaaccagcctgaccgtcggcagctgctcaactccattacccaccct360gagatccgcaaggaaatgatgaaggagaccttcaagtacttctccgaggtaccgatacgt420gat423<210>105<211>117<212>DNA<213>小鼠<400>105agcttggtgctgttcatatttaaactgataaagactcttcataggagctgagggtagcaa60gcccgcgtcggtgactggggtctcacacaggttcagcacttggagcatagtgaggtg117<210>106<211>133<212>DNA<213>小鼠<400>106ttttttttttaaaataccaccatttccaatcccaaaagaacatggcacttgtttgtttct60tccccttctcattcattccagactttcaagtgttttcttcaatactgaggctttctcctg120cagctctggtctg133<210>107<211>217<212>DNA<213>小鼠<220><221>不确定<222>(1)...(1)<221>不确定<222>(11)...(11)<221>不确定<222>(18)...(23)<221>不确定<222>(34)...(34)<221>不确定<222>(37)...(38)<221>不确定<222>(40)...(42)<221>不确定<222>(50)...(52)<221>不确定<222>(55)...(58)<221>不确定<222>(152)...(152)<221>不确定<222>(155)...(155)<221>不确定<222>(165)...(165)<400>107nttttttttgngcgcacnnnnnngnnnncgcccnggnngnnnagcctacnnncannnngt60tttcttctccaggctgaagacctgaacgtcaagttggaaggggagccttccatgcggaaa120ccaaagcagcggccgcggccggagcccctcancanccccaccaangcgggcactttcatc180gcccctcctgtctactccaacatcaccccttaccaga217<210>108<211>346<212>DNA<213>小鼠<220><400>108gggcatagaaggcatctcgaaaagaatacttatttgaattgaaggaagatgaagaggcct60gcaggaaggctcagaagacaggagtgttttacctctttcatgacctggatcctttgctcc120aggcgtcaggacatcgatacctggtgccccggcttagccgagcagagttggaagggctgc180tgggtaagttcggacaggattcgcaaagaattgaagattcggtgctggttgggtgctccg240agcagcaggaagcatggtttgctttggatctaggtctgaagagtgcctcctccagccgtg300gacaagtatcgctgctccagcagcttgactgctgtaaagaggatct346<210>109<211>242<212>DNA<213>小鼠<400>109ccacattgtccacaactggaaggcacgatggttcatccttcggcagaacacgctcctgta60ttacaagctagagggtggccggcgagtaaccccgcccaaggggaggattgtccttgatgg120ctgcaccatcacctgcccctgcctggagtatgaaaaccggccgctcctcattaaactgaa180gacccgaacttccactgagtacttcctggaagcctgttctcgagaggagagagactcctg240gg242<210>110<211>310<212>DNA<213>小鼠<220><400>110cccggccgggaatccaggtggtagctggtggagtcgcctccggagagtgacgcgcagact60cggctcccccgcggcccgccctcctgccggcctcgccgcggtctcccttgctccctgaga120tcgctgagcgctgagcagcggcccgggagaggaggccttgggcgacggggcgcggagagg180gagggcgggcgggcagtgggggcgccgcggatctctatatggcgacggctctgtcgggtc240tggctgtccggctgtcgcgctcggccgnccgcccgctcctatggggtcttctgcaa-gg300ggctgacccg310<210>111<211>228<212>DNA<213>小鼠<400>111ttcttttttaacatttggtggtttttttctttactctttttttcttttccttctttttct60gccctcaaccccccaactcctttggtatgaagtacttttaacatttatatttcattgtta120cactttaaattttgtaaggaaaactctgatatttcattcctcctgaaccactaatgttag180aatttatttctaagaatcagtcaacatgtatactcttaatagtgaatt228<210>112<211>292<212>DNA<213>小鼠<400>112gtggggtcccagacttgccaaccaaagggccattcctggtatatggttctggcttcagct60ctggtggcatggactatggtatggttggtggcaaggaggctgggaccgagtctcgcttca120aacagtggacctcaatgatggaagggctgccatctgtggccacacaagaagccaccatgc180acaaaaacggcgctatagtggcccctggtaagacccgaggaggttcaccatacaaccagt240ttgatataatcccaggtgacacactgggtggccatacgggtcctgctggtga292<210>113<211>255<212>DNA<213>小鼠<220><400>113ttagatgacttaggactttaatgttttccatgcagtcgattgaaaacactgatacatgaa60caaccagaaaaagacctcagcaatgtatagacctggaatatatagtgttgccctggttaa120actacaagaacagccacgtgatcacagtttgagggtggaaggcaggggtgtgactgagtt180ttgtttaacggcctaaccgaaaagcaaagaatcaaccatttcttctacttgtggcaagaa240acgagagtcatggtg255<210>114<211>197<212>DNA<213>小鼠<400>114gacccacatgtgaacagccgcgtgtatgtcacactgctctgtgtgtgatttcttcacgtg60tgcatgtgcgctcttggtctttccacttattgcctcgttcgtaagaaaccaaccataagg120tgccaaggaggttttattccttttttttttaaagatgacaaatgtacagatgttagtaca180gatgttaatgtacagat197<210>115<211>205<212>DNA<213>小鼠<400>115aaaacatttcacaaaacagcaaaacaaaattgatacaatcaaaaaaacaacactataacc60aacataggtgaaaacagccaaacacataatgtacaatctggtgttccaggacaaacatct120gtcatatacatggtatatacatatatactttttcactcaatatattatgacaatatatat180ttaaaattttgttatagacaaaaaa205<210>116<211>202<212>DNA<213>小鼠<220><400>116cctccctcatcctctacttcccttttccttcctgcttgattttctcattccagaccccta60tgcacacacacacacacacacacacacacacacgaacacacgcacacacacacacacacg120cacacacacactgtccatccatagttacttatttagttttccattcctagagagatctaa180tcatcccctagtcagtgcctaa202<210>117<211>240<212>DNA<213>小鼠<400>117ccgccaggagaggagatacacagccagtgatgtggaccaccggatggctgttgctgctgc60cgcttctgctgtgtgaaggagcgcaagccctggagtgctacagctgcgtgcagaaggcgg120acgatggatgcgctccgcacaggatgaagacagtcaaatgtggtcccggggtggacgtct180gtaccgaggccgtgggagcggtagagaccatccacgggcaattctctgtggcggtgcggg240<210>118<211>527<212>DNA<213>人<400>118ccgtcagtctagaaggataagagaaagaaagttaagcaactacaggaaatggctttggga60gttccaatatcagtctatcttttattcaacgcaatgacagcactgaccgaagaggcagcc120gtgactgtaacacctccaatcacagcccagcaaggtaactggacagttaacaaaacagaa180gctcacaacatagaaggacccatagccttgaagttctcacacctttgcctggaagatcat240aacagttactgcatcaacggtgcttgtgcattccaccatgagctagagaaagccatctgc300aggtgttttactggttatactggagaaaggtgtgagcacttgactttaacttcatatgct360gtggattcttatgaaaaatacattgcaattgggattggtgttggattactattaagtggt420tttcttgttattttttactgctatataagaaagaggtgtctaaaattgaaatcgccttac480aatgtctgttctggagaaagacgaccactgtgaggcctttgtgaaga527<210>119<211>655<212>DNA<213>大鼠<400>119atggcgcgccccgcgccctggtggtggctgcggccgctggcggcgctcgccctggcgctg60gcgctggtccgggtgccctcagcccgggccgggcagatgccgcgccccgcagagcgcggg120cccccagtacggctcttcaccgaggaggagctggcccgctacagcggcgaggaggaggat180caacccatctacttggcagtgaagggagtggtgttcgatgtcacctctgggaaggagttt240tatggacgtggagccccctacaacgccttggccgggaaggactcgagcagaggtgtggcc300aagatgtcgctggatcctgcagacctcactcatgacatttctggtctcactgccaaggag360ctggaagccctcgatgacatcttcagcaaggtgtacaaagccaaataccccattgttggc420tacacggcccgcaggatcctcaacgaggatggcagccccaacctggacttcaagcctgaa480gaccagccccattttgacataaaggacgagttctaatgtctagctgagaagctggttcta540gggagaggtgaggggacaggagttaaatgtcccacggaacaagcaggggaagcctctgag600tgctctgcatctgaataaaactgatatttaactgggaaaaaaaaaaaaaaaaaaa655<210>120<211>176<212>蛋白质<213>大鼠<400>120MetValProCysPheLeuLeuSerLeuLeuLeuLeuValArgProAla151015ProValValAlaTyrSerValSerLeuProAlaSerPheLeuGluGlu202530ValAlaGlySerGlyGluAlaGluGlySerSerAlaSerSerProSer354045LeuLeuProProArgThrProAlaPheSerProThrProGlyArgThr505560GlnProThrAlaProValGlyProValProProThrAsnLeuLeuAsp65707580GlyIleValAspPhePheArgGlnTyrValMetLeuIleAlaValVal859095GlySerLeuThrPheLeuIleMetPheIleValCysAlaAlaLeuIle100105110ThrArgGlnLysHisLysAlaThrAlaTyrTyrProSerSerPhePro115120125GluLysLysTyrValAspGlnArgAspArgAlaGlyGlyProHisAla130135140PheSerGluValProAspArgAlaProAspSerArgGlnGluGluGly145150155160LeuAspPhePheGlnGlnLeuGlnAlaAspIleLeuAlaCysTyrSer165170175<210>121<211>116<212>蛋白质<213>大鼠<400>121MetGluLeuLeuTyrTrpCysLeuLeuCysLeuLeuLeuProLeuThr151015SerArgThrGlnLysLeuProThrArgAspGluGluLeuPheGlnMet202530GlnIleArgAspLysAlaLeuPheHisAspSerSerValIleProAsp354045GlyAlaGluIleSerSerTyrLeuPheArgAspThrProArgArgTyr505560PhePheMetValGluGluAspAsnThrProLeuSerValThrValThr65707580ProCysAspAlaProLeuGluTrpLysLeuSerLeuGlnGluLeuPro859095GluGluSerSerAlaAspGlySerGlyAspProGluProLeuAspGln100105110GlnLysGlnGln115<210>122<211>64<212>蛋白质<213>人<400>122MetAsnLeuLeuIleGlySerIleIleLeuSerSerPheLeuValLeu151015SerAspGlyAspThrThrAlaSerProSerSerMetSerSerSerSer202530ValLeuAsnHisIleSerSerSerSerSerSerValTrpHisLeuPhe354045AspIleCysAspSerSerLysTrpAsnAlaTyrCysGlnValTrpGly505560<210>123<211>68<212>蛋白质<213>人<400>123MetLeuThrLeuProIleLeuValCysLysValGlnAspSerAsnArg151015ArgLysMetLeuProThrGlnPheLeuPheLeuLeuGlyValLeuGly202530IlePheGlyLeuThrPheAlaPheIleIleGlyLeuAspGlySerThr354045GlyProThrArgPhePheLeuPheGlyIleLeuPheSerIleCysPhe505560SerCysLeuLeu65<210>124<211>110<212>蛋白质<213>小鼠<400>124MetIleSerProAlaTrpSerLeuPheLeuIleGlyThrLysIleGly151015LeuPhePheGlnValAlaProLeuSerValValAlaLysSerCysPro202530SerValCysArgCysAspAlaGlyPheIleTyrCysAsnAspArgSer354045LeuThrSerIleProValGlyIleProGluAspAlaThrThrLeuTyr505560LeuGlnAsnAsnGlnIleAsnAsnValGlyIleProSerAspLeuLys65707580AsnLeuLeuLysValGlnArgIleTyrLeuTyrHisAsnSerLeuAsp859095GluPheProThrAsnLeuProLysTyrValLysGluLeuHis100105110<210>125<211>330<212>蛋白质<213>小鼠<400>125MetGlySerProArgLeuAlaAlaLeuLeuLeuSerLeuProLeuLeu151015LeuIleGlyLeuAlaValSerAlaArgValAlaCysProCysLeuArg202530SerTrpThrSerHisCysLeuLeuAlaTyrArgValAspLysArgPhe354045AlaGlyLeuGlnTrpGlyTrpPheProLeuLeuValArgLysSerLys505560SerProProLysPheGluAspTyrTrpArgHisArgThrProAlaSer65707580PheGlnArgLysLeuLeuGlySerProSerLeuSerGluGluSerHis859095ArgIleSerIleProSerSerAlaIleSerHisArgGlyGlnArgThr100105110LysArgAlaGlnProSerAlaAlaGluGlyArgGluHisLeuProGlu115120125AlaGlySerGlnLysCysGlyGlyProGluPheSerPheAspLeuLeu130135140ProGluValGlnAlaValArgValThrIleProAlaGlyProLysAla145150155160SerValArgLeuCysTyrGlnTrpAlaLeuGluCysGluAspLeuSer165170175SerProPheAspThrGlnLysIleValSerGlyGlyHisThrValAsp180185190LeuProTyrGluPheLeuLeuProCysMetCysIleGluAlaSerTyr195200205LeuGlnGluAspThrValArgArgLysLysCysProPheGlnSerTrp210215220ProGluAlaTyrGlySerAspPheTrpGlnSerIleArgPheThrAsp225230235240TyrSerGlnHisAsnGlnMetValMetAlaLeuThrLeuArgCysPro245250255LeuLysLeuGluAlaSerLeuCysTrpArgGlnAspProLeuThrPro260265270CysGluThrLeuProAsnAlaThrAlaGlnGluSerGluGlyTrpTyr275280285IleLeuGluAsnValAspLeuHisProGlnLeuCysPheLysPheSer290295300PheGluAsnSerSerHisValGluCysProHisGlnSerGlySerLeu305310315320ProSerTrpThrValSerMetAspThrGln325330<210>126<211>37<212>蛋白质<213>大鼠<400>126MetLeuTrpValLeuLeuSerLeuThrProLeuLeuSerProLeuIle151015PhePheProValLysThrValAlaLeuGluGluIleSerThrIleCys202530ArgAlaAspValLeu35<210>127<211>42<212>蛋白质<213>小鼠<400>127MetGlySerProIleSerGlyValCysProValLeuProGlyGlyLeu151015PheValAlaLeuGlyTrpIlePheLeuLeuPheHisArgAspAlaPhe202530SerLeuHisThrMetSerAlaGlyPhePro3540<210>128<211>253<212>蛋白质<213>小鼠<400>128MetMetTyrTrpIleValPheAlaIlePheMetAlaAlaGluThrPhe151015ThrAspIlePheIleSerTrpSerGlyProArgIleGlyArgProTrp202530GlyTrpGluGlyProHisHisHisHisHisLeuAlaSerGlySerHis354045LysProLeuProLeuLeuThrHisArgPheProPheTyrTyrGluPhe505560LysMetAlaPheValLeuTrpLeuLeuSerProTyrThrLysGlyAla65707580SerLeuLeuTyrArgLysPheValHisProSerLeuSerArgHisGlu859095LysGluIleAspAlaCysIleValGlnAlaLysGluArgSerTyrGlu100105110ThrMetLeuSerPheGlyLysArgSerLeuAsnIleAlaAlaSerAla115120125AlaValGlnAlaAlaThrLysSerGlnGlyAlaLeuAlaGlyArgLeu130135140ArgSerPheSerMetGlnAspLeuArgSerIleProAspThrProVal145150155160ProThrTyrGlnAspProLeuTyrLeuGluAspGlnValProArgArg165170175ArgProProIleGlyTyrArgProGlyGlyLeuGlnGlySerAspThr180185190GluAspGluCysTrpSerAspAsnGluIleValProGlnProProVal195200205ArgProArgGluLysProLeuGlyArgSerGlnSerLeuArgValVal210215220LysArgLysProLeuThrArgGluGlyThrSerArgSerLeuLysVal225230235240ArgThrArgLysLysAlaMetProSerAspMetAspSer245250<210>129<211>40<212>蛋白质<213>小鼠<400>129MetLysAlaMetAlaLeuSerLeuGlyAlaSerProValLeuAlaPhe151015LeuLeuSerGlyTyrSerAspGlyTyrGlnValCysSerArgPheGly202530SerLysValProGlnPheLeuAsn3540<210>130<211>87<212>蛋白质<213>小鼠<400>130MetIleAlaValThrPheAlaIleValLeuGlyValIleIleTyrArg151015IleSerThrAlaAlaAlaLeuAlaMetAsnSerSerProSerValArg202530SerAsnIleArgValThrValThrAlaThrAlaValIleIleAsnLeu354045ValValIleIleLeuLeuAspGluValTyrGlyCysIleAlaArgTrp505560LeuThrLysIleGlyGluCysHisValGlnAspSerIleGlySerMet65707580GlyLeuGlyGlnGlyGlnPro85<210>131<211>70<212>蛋白质<213>小鼠<400>131MetPheGlyLeuValHisValCysThrCysValCysValCysValCys151015ValCysValCysValCysIleCysSerCysGlyTyrValHisValPro202530CysGlyCysValCysLeuTrpGlyProGluValArgTyrLeuProLeu354045SerLeuHisProGlyGlyPheCysPheValLeuPheCysPheGlyPro505560GlyLeuSerLeuIleSer6570<210>132<211>63<212>蛋白质<213>小鼠<400>132MetTrpLeuLeuValAlaLeuThrLeuSerValTyrSerLeuValAla151015PheValThrGlyMetLeuCysAspThrValValIleLysMetLeuMet202530SerLeuHisLysSerSerLysLeuAsnProArgAlaLysCysGlyGly354045ValProLeuIleProAlaLeuTrpGlyGlnValGlnValValLeu505560<210>133<211>39<212>蛋白质<213>小鼠<400>133MetAspAsnThrLeuSerIleIleIleTyrLeuLeuPheIlePheAla151015IleSerValLeuAspSerGlnLeuSerThrArgCysLeuTrpTrpPhe202530SerLysAspLeuGluValThr35<210>134<211>90<212>蛋白质<213>大鼠<400>134MetProThrMetTrpProLeuLeuHisValLeuTrpLeuAlaLeuVal151015CysGlySerValHisThrThrLeuSerLysSerAspAlaLysLysAla202530AlaSerLysThrLeuLeuGluLysThrGlnPheSerAspLysProVal354045GlnAspArgGlyLeuValValThrAspIleLysAlaGluAspValVal505560LeuGluHisArgSerTyrCysSerAlaArgAlaArgGluArgAsnPhe65707580AlaGlyGluValLeuGlyIleCysHisSer8590<210>135<211>193<212>蛋白质<213>大鼠<400>135MetThrSerGlyProGlyGlyProAlaAlaAlaThrGlyGlyGlyLys151015AspThrHisGlnTrpTyrValCysAsnArgGluLysLeuCysGluSer202530LeuGlnSerValPheValGlnSerTyrLeuAspGlnGlyThrGlnIle354045PheLeuAsnAsnSerIleGluLysSerGlyTrpLeuPheIleGlnLeu505560TyrHisSerPheValSerSerValPheThrLeuPheMetSerArgThr65707580SetIleAsnGlyLeuLeuGlyArgGlySerMetPheValPheSerPro859095AspGlnPheGlnArgLeuLeuLysIleAsnProAspTrpLysThrHis100105110ArgLeuLeuAspLeuGlyAlaGlyAspGlyGluValThrLysIleMet115120125SerProHisPheGluGluIleTyrAlaThrGluLeuSerGluThrMet130135140IleTrpGlnLeuGlnLysLysLysTyrArgValLeuGlyIleAsnGlu145150155160TrpGlnAsnThrGlyPheGlnTyrAspValIleSerCysLeuAsnLeu165170175LeuAspArgCysAspGlnProLeuThrLeuLeuLysAspIleArgMet180185190Ser<210>136<211>106<212>蛋白质<213>大鼠<400>136MetAlaAlaProMetAspArgThrHisGlyGlyArgAlaAlaArgAla151015LeuArgArgAlaLeuAlaLeuAlaSerLeuAlaGlyLeuLeuLeuSer202530GlyLeuAlaGlyAlaLeuProThrLeuGlyProGlyTrpArgArgGln354045AsnProGluProProAlaSerArgThrArgSerLeuLeuLeuAspAla505560AlaSerGlyGlnLeuArgLeuGluTyrGlyPheHisProAspAlaVal65707580AlaTrpAlaAsnLeuThrAsnAlaIleArgGluThrGlyTrpAlaTyr859095LeuAspLeuGlyThrAsnGlySerTyrLys100105<210>137<211>286<212>蛋白质<213>大鼠<400>137MetAlaAlaAlaMetProLeuGlyLeuSerLeuLeuLeuLeuValLeu151015ValGlyGlnGlyCysCysGlyArgValGluGlyProArgAspSerLeu202530ArgGluGluLeuValIleThrProLeuProSerGlyAspValAlaAla354045ThrPheGlnPheArgThrArgTrpAspSerAspLeuGlnArgGluGly505560ValSerHisTyrArgLeuPheProLysAlaLeuGlyGlnLeuIleSer65707580LysTyrSerLeuArgGluLeuHisLeuSerPheThrGlnGlyPheTrp859095ArgThrArgTyrTrpGlyProProPheLeuGlnAlaProSerGlyAla100105110GluLeuTrpValTrpPheGlnAspThrValThrAspValAspLysSer115120125TrpLysGluLeuSerAsnValLeuSerGlyIlePheCysAlaSerLeu130135140AsnPheIleAspSerThrAsnThrValThrProThrAlaSerPheLys145150155160ProLeuGlyLeuAlaAsnAspThrAspHisTyrPheLeuArgTyrAla165170175ValLeuProArgGluValValCysThrGluAsnLeuThrProTrpLys180185190LysLeuLeuProCysSerSerLysAlaGlyLeuSerValLeuLeuLys195200205AlaAspArgLeuPheHisThrSerTyrHisSerGlnAlaValHisIle210215220ArgProIleCysArgAsnAlaHisCysThrSerIleSerTrpGluLeu225230235240ArgGlnThrLeuSerValValPheAspAlaPheIleThrGlyGlnGly245250255LysLysGluAlaCysProLeuAlaSerGlnSerLeuValTyrValAsp260265270IleThrGlyTyrSerGlnAspAsnGluThrLeuGluValSer275280285<210>138<211>198<212>蛋白质<213>大鼠<400>138MetThrValPheArgLysValThrThrMetIleSerTrpMetLeuLeu151015AlaCysAlaLeuProCysAlaAlaAspProMetLeuGlyAlaPheAla202530ArgArgAspPheGlnLysGlyGlyProGlnLeuValCysSerLeuPro354045GlyProGlnGlyProProGlyProProGlyAlaProGlySerSerGly505560MetValGlyArgMetGlyPheProGlyLysAspGlyGlnAspGlyGln65707580AspGlyAspArgGlyAspSerGlyGluGluGlyProProGlyArgThr859095GlyAsnArgGlyLysGlnGlyProLysGlyLysAlaGlyAlaIleGly100105110ArgAlaGlyProArgGlyProLysGlyValSerGlyThrProGlyLys115120125HisGlyIleProGlyLysLysGlyProLysGlyLysLysGlyGluPro130135140GlyLeuProGlyProCysSerCysGlySerSerArgAlaLysSerAla145150155160PheSerValAlaValThrLysSerTyrProArgGluArgLeuProIle165170175LysPheAspLysIleLeuMetAsnGluGlyGlyHisTyrAsnAlaSer180185190SerGlyLysPheValCys195<210>139<211>233<212>蛋白质<213>大鼠<400>139MetAlaSerAlaLeuGluGluLeuGlnLysAspLeuGluGluValLys151015ValLeuLeuGluLysSerThrArgLysArgLeuArgAspThrLeuThr202530AsnGluLysSerLysIleGluThrGluLeuArgAsnLysMetGlnGln354045LysSerGlnLysLysProGluPheAspAsnGluLysProAlaAlaVal505560ValAlaProLeuThrThrGlyTyrThrValLysIleSerAsnTyrGly65707580TrpAspGlnSerAspLysPheValLysIleTyrIleThrLeuThrGly859095ValHisGlnValProAlaGluAsnValGlnValHisPheThrGluArg100105110SerPheAspLeuLeuValLysAsnLeuAsnGlyLysAsnTyrSerMet115120125IleValAsnAsnLeuLeuLysProIleSerValGluSerSerSerLys130135140LysValLysThrAspThrValIleIleLeuCysArgLysLysAlaGlu145150155160AsnThrArgTrpAspTyrLeuThrGlnValGluLysGluCysLysGlu165170175LysGluLysProSerTyrAspThrGluAlaAspProSerGluGlyLeu180185190MetAsnValLeuLysLysIleTyrGluAspGlyAspAspAspMetLys195200205ArgThrIleAsnLysAlaTrpValGluSerArgGluLysGlnAlaArg210215220GluAspThrGluPheLeuGlnProGly225230<210>140<211>38<212>蛋白质<213>人<400>140MetGlyLeuAlaLeuCysLeuAlaSerAlaGlyIleSerGlySerArg151015SerAlaPheLeuGlyValProArgProArgProThrLeuIleLysLeu202530IleAspThrValAspLeu35<210>141<211>322<212>蛋白质<213>小鼠<400>141MetAspAlaArgTrpTrpAlaValValValLeuAlaThrLeuProSer151015LeuGlyAlaGlyGlyGluSerProGluAlaProProGlnSerTrpThr202530GlnLeuTrpLeuPheArgPheLeuLeuAsnValAlaGlyTyrAlaSer354045PheMetValProGlyTyrLeuLeuValGlnTyrLeuArgArgLysAsn505560TyrLeuGluThrGlyArgGlyLeuCysPheProLeuValLysAlaCys65707580ValPheGlyAsnGluProLysAlaProAspGluValLeuLeuAlaPro859095ArgThrGluThrAlaGluSerThrProSerTrpGlnValLeuLysLeu100105110ValPheCysAlaSerGlyLeuGlnValSerTyrLeuThrTrpGlyIle115120125LeuGlnGluArgValMetThrGlySerTyrGlyAlaThrAlaThrSer130135140ProGlyGluHisPheThrAspSerGlnPheLeuValLeuMetAsnArg145150155160ValLeuAlaLeuValValAlaGlyLeuTyrCysValLeuArgLysGln165170175ProArgHisGlyAlaProMetTyrArgTyrSerPheAlaSerLeuSer180185190AsnValLeuSerSerTrpCysGlnTyrGluAlaLeuLysPheValSer195200205PheProThrGlnValLeuAlaLysAlaSerLysValIleProValMet210215220MetMetGlyLysLeuValSerArgArgSerTyrGluHisTrpGluTyr225230235240LeuThrAlaGlyLeuIleSerIleGlyValSerMetPheLeuLeuSer245250255SerGlyProGluProArgSerSerProAlaThrThrLeuSerGlyLeu260265270ValLeuLeuAlaGlyTyrIleAlaPheAspSerPheThrSerAsnTrp275280285GlnAspAlaLeuPheAlaTyrLysMetSerSerValGlnMetMetPhe290295300GlyValAsnLeuPheSerCysLeuPheThrValGlySerLeuLeuGlu305310315320GlnGly<210>142<211>312<212>蛋白质<213>小鼠<400>142MetLeuCysLeuCysLeuTyrValProIleAlaGlyAlaAlaGlnThr151015GluPheGlnTyrPheGluSerLysGlyLeuProAlaGluLeuLysSer202530IlePheLysLeuSerValPheIleProSerGlnGluPheSerThrTyr354045ArgGlnTrpLysGlnLysIleValGlnAlaGlyAspLysAspLeuAsp505560GlyGlnLeuAspPheGluGluPheValHisTyrLeuGlnAspHisGlu65707580LysLysLeuArgLeuValPheLysSerLeuAspLysLysAsnAspGly859095ArgIleAspAlaGlnGluIleMetGlnSerLeuArgAspLeuGlyVal100105110LysIleSerGluGlnGlnAlaGluLysIleLeuLysSerMetAspLys115120125AsnGlyThrMetThrIleAspTrpAsnGluTrpArgAspTyrHisLeu130135140LeuHisProValGluAsnIleProGluIleIleLeuTyrTrpLysHis145150155160SerThrIlePheAspValGlyGluAsnLeuThrValProAspGluPhe165170175ThrValGluGluArgGlnThrGlyMetTrpTrpArgHisLeuValAla180185190GlyGlyGlyAlaGlyAlaValSerArgThrCysThrAlaProLeuAsp195200205ArgLeuLysValLeuMetGlnValHisAlaSerArgSerAsnAsnMet210215220CysIleValGlyGlyPheThrGlnMetIleArgGluGlyGlyAlaLys225230235240SerLeuTrpArgGlyAsnGlyIleAsnValLeuLysIleAlaProGlu245250255SerAlaIleLysPheMetAlaTyrGluGlnMetLysArgLeuValGly260265270SerAspGlnGluThrLeuArgIleHisGluArgLeuValAlaGlySer275280285LeuAlaGlyAlaIleAlaGlnSerSerIleTyrProMetGluValLeu290295300LysThrArgMetAlaLeuArgLys305310<210>143<211>163<212>蛋白质<213>大鼠<400>143MetProLeuValThrThrLeuPheTyrAlaCysPheTyrHisTyrThr151015GluSerGluGlyThrPheSerSerProValAsnLeuLysLysThrPhe202530LysIleProAspArgGlnTyrValLeuThrAlaLeuAlaAlaArgAla354045LysLeuArgAlaTrpAsnAspValAspAlaLeuPheThrThrLysAsn505560TrpLeuGlyTyrThrLysLysArgAlaProIleGlyPheHisArgVal65707580ValGluIleLeuHisLysAsnSerAlaProValGlnIleLeuGlnGlu859095TyrValAsnLeuValGluAspValAspThrLysLeuAsnLeuAlaThr100105110LysPheLysCysHisAspValValIleAspThrCysArgAspLeuLys115120125AspArgGlnGlnLeuLeuAlaTyrArgSerLysValAspLysGlySer130135140AlaGluGluGluLysIleAspValIleLeuSerSerSerGlnIleArg145150155160TrpLysAsn<210>144<211>330<212>蛋白质<213>大鼠<400>144MetAlaGlyTrpAlaGlyAlaGluLeuSerValLeuAsnProLeuArg151015AlaLeuTrpLeuLeuLeuAlaAlaAlaPheLeuLeuAlaLeuLeuLeu202530GlnLeuAlaProAlaArgLeuLeuProSerCysAlaLeuPheGlnAsp354045LeuIleArgTyrGlyLysThrLysGlnSerGlySerArgArgProAla505560ValCysArgAlaPheAspValProLysArgTyrPheSerHisPheTyr65707580ValValSerValLeuTrpAsnGlySerLeuLeuTrpPheLeuSerGln859095SerLeuPheLeuGlyAlaProPheProSerTrpLeuTrpAlaLeuLeu100105110ArgThrLeuGlyValThrGlnPheGlnAlaLeuGlyMetGluSerLys115120125AlaSerArgIleGlnAlaGlyGluLeuAlaLeuSerThrPheLeuVal130135140LeuValPheLeuTrpValHisSerLeuArgArgLeuPheGluCysPhe145150155160TyrValSerValPheSerAsnThrAlaIleHisValValGlnTyrCys165170175PheGlyLeuValTyrTyrValLeuValGlyLeuThrValLeuSerGln180185190ValProMetAsnAspLysAsnValTyrAlaLeuGlyLysAsnLeuLeu195200205LeuGlnAlaArgTrpPheHisIleLeuGlyMetMetMetPhePheTrp210215220SerSerAlaHisGlnTyrLysCysHisValIleLeuSerAsnLeuArg225230235240ArgAsnLysLysGlyValValIleHisCysGlnHisArgIleProPhe245250255GlyAspTrpPheGluTyrValSerSerAlaAsnTyrLeuAlaGluLeu260265270MetIleTyrIleSerMetAlaValThrPheGlyLeuHisAsnValThr275280285TrpTrpLeuValValThrTyrValPhePheSerGlnAlaLeuSerAla290295300PhePheAsnHisArgPheTyrLysSerThrPheValSerTyrProLys305310315320HisArgLysAlaPheLeuProPheLeuPhe325330<210>145<211>301<212>蛋白质<213>大鼠<400>145MetLeuValAlaPheLeuGlyAlaSerAlaValThrAlaSerThrGly151015LeuLeuTrpLysLysAlaHisAlaGluSerProProSerValAsnSer202530LysLysThrAspAlaGlyAspLysGlyLysSerLysAspThrArgGlu354045ValSerSerHisGluGlySerAlaAlaAspThrAlaAlaGluProTyr505560ProGluGluLysLysLysLysArgSerGlyPheArgAspArgLysVal65707580MetGluTyrGluAsnArgIleArgAlaTyrSerThrProAspLysIle859095PheArgTyrPheAlaThrLeuLysValIleAsnGluProGlyGluThr100105110GluValPheMetThrProGlnAspPheValArgSerIleThrProAsn115120125GluLysGlnProGluHisLeuGlyLeuAspGlnTyrIleIleLysArg130135140PheAspGlyLysLysIleAlaGlnGluArgGluLysPheAlaAspGlu145150155160GlySerIlePheTyrThrLeuGlyGluCysGlyLeuIleSerPheSer165170175AspTyrIlePheLeuThrThrValLeuSerThrProGlnArgAsnPhe180185190GluIleAlaPheLysMetPheAspLeuAsnGlyAspGlyGluValAsp195200205MetGluGluPheGluGlnValGlnSerIleIleArgSerGlnThrSer210215220MetGlyMetArgHisArgAspArgProThrThrGlyAsnThrLeuLys225230235240SerGlyLeuCysSerAlaLeuThrThrTyrPhePheGlyAlaAspLeu245250255LysGlyLysLeuThrIleLysAsnPheLeuGluPheGlnArgLysLeu260265270GlnArgCysLeuLeuGlyLeuProValTrpGluGlySerProHisLeu275280285ProThrGlyHisTrpLeuArgGluLeuTrpSerLeuLeu290295300<210>146<211>61<212>蛋白质<213>大鼠<400>146MerGluAsnIleTyrTyrThrAsnLeuIleThrIleLeuGlyAsnLys151015HisAlaAsnGlnMetGluLeuAsnLeuGlnAlaLeuIleLeuSerPro202530TrpPheAlaValCysAlaProProGlyPheAlaArgAspGlnAlaVal354045ArgGlyLeuAlaLeuAlaGlyArgArgIleThrValVal505560<210>147<211>105<212>蛋白质<213>大鼠<400>147MetLeuArgArgGlnLeuValTrpTrpHisLeuLeuAlaLeuLeuPhe151015LeuProPheCysLeuCysGlnAspGluTyrMetGluSerProGlnAla202530GlyGlyLeuProProAspCysSerLysCysCysHisGlyAspTyrGly354045PheArgGlyTyrGlnGlyProProGlyProProGlyProProGlyIle505560ProGlyAsnHisGlyAsnAsnGlyAsnAsnGlyAlaThrGlyHisGlu65707580GlyAlaLysGlyGluLysGlyAspLysGlyAspLeuGlyProArgGly859095GluArgGlyGlnHisGlyProLysGly100105<210>148<211>210<212>蛋白质<213>大鼠<400>148MetLeuGlyAlaThrSerLeuSerTrpProTrpValLeuTrpAlaVal151015AlaGlnArgAspSerValAspAlaIleGlyMetPheLeuGlyGlyLeu202530ValAlaThrIlePheLeuAspIleIleTyrIleSerIlePheTyrSer354045SerValAlaValGlyAspThrGlyArgPheSerAlaGlyMetAlaIle505560PheSerLeuLeuLeuGlnAlaLeuLeuLeuLeuProArgLeuProHis65707580AlaProGlySerGluGlyValSerSerArgSerAlaArgIleSerSer859095AspLeuLeuArgAsnIleValProThrArgGlnLeuThrArgGlnThr100105110HisLeuGlnThrProLeuGlnAlaTrpArgThrArgAlaLysLeuPro115120125ProGlyGlyThrGluAlaValProGlyArgProGlyAlaGlnGlnAsp130135140AlaCysHisLeuLeuTyrTrpThrTyrAsnGlyValSerSerIlePro145150155160CysHisArgGlyGlyLeuSerHisValProSerGluValProAlaGlu165170175LysSerProValLeuIleLeuHisAlaAlaProProPheLysThrPro180185190ValAsnProTrpAlaArgThrValValGlyPhePheProSerSerPro195200205SerLeu210<210>149<211>301<212>蛋白质<213>大鼠<400>149MetLeuValAlaPheLeuGlyAlaSerAlaValThrAlaSerThrGly151015LeuLeuTrpLysLysAlaHisAlaGluSerProProSerValAsnSer202530LysLysThrAspAlaGlyAspLysGlyLysSerLysAspThrArgGlu354045ValSerSerHisGluGlySerAlaAlaAspThrAlaAlaGluProTyr505560ProGluGluLysLysLysLysArgSerGlyPheArgAspArgLysVal65707580MetGluTyrGluAsnArgIleArgAlaTyrSerThrProAspLysIle859095PheArgTyrPheAlaThrLeuLysValIleAsnGluProGlyGluThr100105110GluValPheMetThrProGlnAspPheValArgSerIleThrProAsn115120125GluLysGinProGluHisLeuGlyLeuAspGlnTyrIleIleLysArg130135140PheAspGlyLysLysIleAlaGlnGluArgGluLysPheAlaAspGlu145150155160GlySerIlePheTyrThrLeuGlyGluCysGlyLeuIleSerPheSer165170175AspTyrIlePheLeuThrThrValLeuSerThrProGlnArgAsnPhe180185190GluIleAlaPheLysMetPheAspLeuAsnGlyAspGlyGluValAsp195200205MetGluGluPheGluGlnValGlnSerIleIleArgSerGlnThrSer210215220MetGlyMetArgHisArgAspArgProThrThrGlyAsnThrLeuLys225230235240SerGlyLeuCysSerAlaLeuThrThrTyrPhePheGlyAlaAspLeu245250255LysGlyLysLeuThrIleLysAsnPheLeuGluPheGlnArgLysLeu260265270GlnArgCysLeuLeuGlyLeuProValTrpGluGlySerProHisLeu275280285ProThrGlyHisTrpLeuArgGluLeuTrpSerLeuLeu290295300<210>150<211>80<212>蛋白质<213>人<400>150MetLysLeuSerGlyMetPheLeuLeuLeuSerLeuAlaLeuPheCys151015PheLeuThrGlyValPheSerGlnGlyGlyGlnValAspCysGlyGlu202530PheGlnAspThrLysValTyrCysThrArgGluSerAsnProHisCys354045GlySerAspGlyGlnThrTyrGlyAsnLysCysAlaPheCysLysAla505560IleValLysSerGlyGlyLysIleSerLeuLysHisProGlyLysCys65707580<210>151<211>27<212>蛋白质<213>小鼠<400>151MetLeuLysAlaSerLeuHisIleLeuPheLeuGlyIleLeuAsnVal151015ProIleValAspThrSerThrLysThrGlyVal2025<210>152<211>86<212>蛋白质<213>小鼠<400>152MetLeuGlnGlyProAlaProSerCysPheTrpValPheSerGlyIle151015CysValPheTrpAspPheIlePheIleIlePhePheAsnValLeuSer202530LeuGlyAsnArgGluIleSerAlaLysAspPheAlaAspGlnProAla354045GlyAlaGlnGlyMetTrpGlyIleTrpGlyHisThrIleThrCysGly505560LeuAlaProGlyAlaLysProCysSerLeuLysArgGluGlyProAsp65707580LeuLeuSerPheProPro85<210>153<211>72<212>蛋白质<213>小鼠<400>153MetSerAlaIlePheAsnPheGlnSerLeuLeuThrValIleLeuLeu151015LeuIleCysThrCysAlaTyrIleArgSerLeuAlaProSerIleLeu202530AspArgAsnLysThrGlyLeuLeuGlyIlePheTrpLysCysAlaArg354045IleGlyGluArgLysSerProTyrValAlaIleCysCysIleValMet505560AlaPheSerIleLeuPheIleGln6570<210>154<211>169<212>蛋白质<213>小鼠<400>154MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>155<211>61<212>蛋白质<213>小鼠<400>155MetGluLysGlnMetAspAlaSerValSerValIlePheGlySerIle151015ValIleSerAlaPheLeuTyrLeuSerLeuAlaGlyProTrpAlaVal202530ThrValThrGlnMetArgThrIleIleIleThrMetAspGlnLeuArg354045AspAlaLeuIleLeuAspGlnLeuLysValAlaValSer505560<210>156<211>131<212>蛋白质<213>小鼠<400>156MetAlaProSerLeuTrpLysGlyLeuValGlyValGlyLeuPheAla151015LeuAlaHisAlaAlaPheSerAlaAlaGlnHisArgSerTyrMetArg202530LeuThrGluLysGluAspGluSerLeuProIleAspIleValLeuGln354045ThrLeuLeuAlaPheAlaValThrCysTyrGlyIleValHisIleAla505560GlyGluPheLysAspMetAspAlaThrSerGluLeuLysAsnLysThr65707580PheAspThrLeuArgAsnHisProSerPheTyrValPheAsnHisArg859095GlyArgValLeuPheArgProSerAspAlaThrAsnSerSerAsnLeu100105110AspAlaLeuSerSerAsnThrSerLeuLysLeuArgLysPheAspSer115120125LeuArgArg130<210>157<211>133<212>蛋白质<213>小鼠<400>157MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysGluHisVal505560GlnGlyThrGlyAlaArgSerThrAlaCysThrLeuSerCysArgAla65707580ProAsnAlaSerSerSerGlyThrMetProGlyThrArgSerAlaGly859095SerThrLysAsnArgValAspAspHisGlyLysLysAsnSerArgPro100105110ValGluArgLeuGlnGlnArgThrLeuGlnIleLysIleLysAlaLeu115120125SerPheSerGlnAla130<210>158<211>78<212>蛋白质<213>小鼠<400>158GlyThrArgLysProLeuProMetGluAlaHisSerArgArgGluLys151015AlaSerGlyLeuArgLeuAlaTrpHisTyrGluCysSerGlyValSer202530ValTrpTrpMetCysValLeuGlyTrpLeuSerPheLeuValPheLeu354045LeuPheSerLeuValCysSerPheProSerProIleAsnHisSerHis505560MetLeuProCysLeuPheLeuArgGlyGlyGlySerAsnVal657075<210>159<211>206<212>蛋白质<213>小鼠<400>159MetLeuProProAlaIleHisLeuSerLeuIleProLeuLeuCysIle151015LeuMetArgAsnCysLeuAlaPheLysAsnAspAlaThrGluIleLeu202530TyrSerHisValValLysProValProAlaHisProSerSerAsnSer354045ThrLeuAsnGlnAlaArgAsnGlyGlyArgHisPheSerSerThrGly505560LeuAspArgAsnSerArgValGlnValGlyCysArgGluLeuArgSer65707580ThrLysTyrIleSerAspGlyGlnCysThrSerIleSerProLeuLys859095GluLeuValCysAlaGlyGluCysLeuProLeuProValLeuProAsn100105110TrpIleGlyGlyGlyTyrGlyThrLysTyrTrpSerArgArgSerSer115120125GlnGluTrpArgCysValAsnAspLysThrArgThrGlnArgIleGln130135140LeuGlnCysGlnAspGlySerThrArgThrTyrLysIleThrValVal145150155160ThrAlaCysLysCysLysArgTyrThrArgGlnHisAsnGluSerSer165170175HisAsnPheGluSerValSerProAlaLysProAlaGlnHisHisArg180185190GluArgLysArgAlaSerLysSerSerLysHisSerLeuSer195200205<210>160<211>169<212>蛋白质<213>小鼠<400>160MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>161<211>114<212>蛋白质<213>小鼠<400>161MetSerValThrIleGlyArgLeuAlaLeuPheLeuIleGlyIleLeu151015LeuCysProValAlaProSerLeuThrArgSerTrpProGlyProAsp202530ThrCysSerLeuPheLeuGlnHisSerLeuSerLeuSerLeuArgLeu354045GlyGlnSerLeuGluGlyGlyLeuSerValCysPheHisValCysIle505560HisAlaCysGluCysValAlaCysCysArgValLeuTrpAspProLys65707580ProArgGlySerSerLeuCysArgTrpValLeuGlySerIleThrCys859095LeuPheMetTyrGluValGlyGlyTrpThrGlnGlyGlyLeuIleVal100105110SerLeu<210>162<211>46<212>蛋白质<213>小鼠<400>162MetHisTyrProCysLeuAlaCysLeuPheValAsnValHisTrpCys151015PheAlaTrpMetCysIleLeuValLysMetSerGluLeuLeuGluLeu202530GluLeuGluThrMetValSerCysLeuValAspValGlyAsn354045<210>163<211>122<212>蛋白质<213>小鼠<400>163MetPheThrPheValValLeuValIleThrIleValIleCysLeuCys151015HisValCysPheGlyHisPheLysTyrLeuSerAlaHisAsnTyrLys202530IleGluHisThrGluThrAspAlaValSerSerArgSerAsnGlyArg354045ProProThrAlaGlyAlaValProLysSerAlaLysTyrIleAlaGln505560ValLeuGlnAspSerGluGlyAspGlyAspGlyAspGlyAlaProGly65707580SerSerGlyAspGluProProSerSerSerSerGlnAspGluGluLeu859095LeuMetProProAspGlyLeuThrAspThrAspPheGlnSerCysGlu100105110AspSerLeuIleGluAsnGluIleHisGln115120<210>164<211>60<212>蛋白质<213>大鼠<400>164MetSerPheValLysIleGluAlaThrProThrGlnThrLysTrpPro151015PheSerValValProGlnSerLeuLeuValThrValTyrIleCysTyr202530IlePheLeuValIlePhePhePhePhePheGluAlaCysGlnGluVal354045LeuCysSerPhePheAspPheSerArgArgArgGly505560<210>165<211>57<212>蛋白质<213>小鼠<400>165MetGlySerProIleSerGlyValCysProValLeuProGlyGlyLeu151015PheValAlaLeuGlyTrpIlePheLeuLeuPheHisArgAspAlaPhe202530SerLeuHisThrMetSerAlaGlyPheProLysSerProAlaAsnPro354045HisHisProProLeuArgLeuSerPro5055<210>166<211>75<212>蛋白质<213>小鼠<400>166LysThrArgArgThrLeuThrGlyGlnLeuGlyLeuPheSerValAsp151015PheMetValCysIlePheLeuPheLeuPhePheCysPheLeuPhePro202530PheProLeuPheLeuValArgLysHisIleLeuLeuSerHisCysLys354045GlnTrpGluGlySerThrMetThrHisThrHisThrHisThrHisIle505560HisIleHisThrProProArgGlnCysGlnSer657075<210>167<211>52<212>蛋白质<213>小鼠<400>167ValArgSerLeuGluGlnLeuGlyLeuPheSerValAspPheMetVal151015CysIlePheLeuPheLeuPhePheCysPheLeuPheProPheProLeu202530PheLeuValArgLysHisIleLeuLeuSerHisCysLysGlnTrpGlu354045GlySerThrMet50<210>168<211>119<212>蛋白质<213>大鼠<400>168MetLeuGlyAlaThrSerLeuSerTrpProTrpValLeuTrpAlaVal151015AlaGlnArgAspSerValAspAlaIleGlyMetPheLeuGlyGlyLeu202530ValAlaThrIlePheLeuAspIleIleTyrIleSerIlePheTyrSer354045SerValAlaValGlyAspThrGlyArgPheSerAlaGlyMetAlaIle505560PheSerLeuLeuLeuGlnAlaLeuLeuLeuLeuProArgLeuProHis65707580AlaProGlySerGluGlyValSerSerArgSerAlaArgIleSerSer859095AspLeuLeuArgAsnIleValProThrArgGlnLeuThrArgGlnThr100105110HisLeuGlnThrProLeuGln115<210>159<211>104<212>蛋白质<213>大鼠<220><400>169LeuValProLysSerAlaArgAlaSerLeuLeuCysCysGlyProLys151015LeuAlaAlaCysGlyIleValLeuSerAlaTrpGlyValIleMetLeu202530IleMetLeuGlyIlePhePheAsnValHisSerAlaValXaaIleXaa354045AspValProPheThrGluLysAspPheGluAsnGlyProGlnAsnIle505560TyrAsnLeuTyrGluGlnValSerTyrAsnCysPheIleAlaAlaGly65707580LeuTyrLeuLeuXaaGlyGlyPheSerPheCysGlnValArgLeuAsn859095LysArgLysGluTyrMetValArg100<210>170<211>123<212>蛋白质<213>大鼠<220><221>不确定<222>(27)...(27)<221>不确定<222>(104)...(104)<221>不确定<222>(118)...(118)<400>170MetArgProGlyAlaAspTrpAlaAlaValCysAlaLeuTrpProSer151015TrpArgProSerCysSerLeuProSerSerXaaArgIleGlnProAsp202530GluLeuTrpLeuTyrArgAsnProTyrValLysAlaGluTyrPhePro354045ThrGlyProMetPheValIleAlaPheLeuThrProLeuSerLeuIle505560PhePheAlaLysPheLeuArgLysAlaAspAlaAspArgGlnArgAla65707580SerLeuProArgCysGlnProCysProSerAlaLysTrpCysLeuTyr859095GlnHisHisLysThrAspSerXaaGlnGlyHisAlaGlnIleAlaSer100105110ThrGluCysSerProXaaGlyIleAlaHisSer115120<210>171<211>75<212>蛋白质<213>大鼠<400>171SerAlaGlyValMetThrAlaAlaValPhePheGlyCysAlaPheIle151015AlaPheGlyProAlaLeuSerLeuTyrValPheThrIleAlaThrAsp202530ProLeuArgValIlePheLeuIleAlaGlyAlaPhePheTrpLeuVal354045SerLeuLeuLeuSerSerValPheTrpPheLeuValArgValIleThr505560AspAsnArgAspGlyProValGlnAsnTyrLeu657075<210>172<211>79<212>蛋白质<213>人<400>172LysThrSerTyrHisTyrHisThrAsnValGluGluLeuThrIlePro151015GluThrArgAsnAsnLeuTyrIleSerIleSerTrpLeuTrpCysLeu202530ValLeuValLeuLeuSerThrMetIleLeuAsnLysHisGlyTrpMet354045LysAlaAsnAlaTyrSerLeuValProSerIleIleTyrSerProSer505560TyrLeuLysLeuLeuLeuArgLeuTyrLysLeuGlnIleCysCys657075<210>173<211>134<212>蛋白质<213>人<220><400>173LeuArgGlyArgGlyArgGlyValCysSerGlnGluSerPheGlyGly151015CysCysValSerGlyLeuIleAlaMetGlyThrLysAlaGlnValGlu202530ArgLysLeuLeuCysLeuPheIleLeuAlaIleLeuLeuCysSerLeu354045AlaLeuGlySerValThrValHisSerSerGluProGluValArgIle505560ProGluAsnAsnProValLysLeuSerCysAlaTyrSerGlyPheSer65707580SerProArgValGluTrpLysPheAspGlnGlyAspThrThrArgLeu859095ValCysTyrAsnAsnLysIleThrAlaSerTyrGluAspArgValThr100105110PheLeuProThrGlyIleThrPheLysSerValThrArgGluAspThr115120125GlyThrTyrThrCysMet130<210>174<211>137<212>蛋白质<213>人<400>174AlaTrpSerArgProArgTyrAspSerValLeuAlaLeuSerAlaAla151015LeuGlnAlaThrArgAlaLeuMetValValSerLeuValLeuGlyPhe202530LeuAlaMetPheValAlaThrMetGlyMetLysCysThrArgCysGly354045GlyAspAspLysValLysLysAlaArgIleAlaMetGlyGlyGlyIle505560IlePheIleValAlaGlyLeuAlaAlaLeuValAlaCysSerTrpTyr65707580GlyHisGlnIleValThrAspPheTyrAsnProLeuIleProThrAsn859095IleLysTyrGluPheGlyProAlaIlePheIleGlyTrpAlaGlySer100105110AlaLeuValIleLeuGlyGlyAlaLeuSerProValProValLeuGly115120125IleArgAlaGlyLeuGlyThrCysPro130135<210>175<211>43<212>蛋白质<213>人<400>175MetLysLeuSerGlyMetPheLeuLeuLeuSerLeuAlaLeuPheCys151015PheLeuThrGlyValPheSerGlnGlyGlyGlnValAspCysGlyGlu202530SerArgThrProArgProThrAlaLeuGlyAsn3540<210>176<211>63<212>蛋白质<213>大鼠<400>176ProAsnThrArgProArgArgHisThrAlaCysArgValSerIleSer151015ValPheTyrMetLeuHisThrGluLeuLysLysCysTrpPhePheLeu202530PheCysPheSerLeuPheLeuTrpPheCysPheTrpPheCysPheLeu354045LeuProArgPheAspTyrLeuProMetProSerThrArgProArg505560<210>177<211>52<212>蛋白质<213>小鼠<400>177MetLeuGlnGlyProAlaProSerCysPheTrpValPheSerGlyIle151015CysValPheTrpAspPheIlePheIleIlePhePheAsnValLeuSer202530LeuGlyAsnArgGluIleSerAlaLysAspPheAlaAspGlnProAla354045GlyAlaGlnGly50<210>178<211>62<212>蛋白质<213>小鼠<400>178ValSerProArgProThrTyrProSerThrAlaSerSerMetAlaAla151015PheLeuValThrGlyPhePhePheSerLeuPheValValLeuGlyMet202530GluProArgAlaLeuPheArgProAspLysAlaLeuProLeuSerCys354045AlaLysProThrSerLeuCysValGlnSerSerPheLeuGly505560<210>179<211>123<212>蛋白质<213>小鼠<400>179AlaSerArgThrAlaValMetSerLeuCysArgCysGlnGlnGlySer151015ArgSerArgMetAspLeuAspValValAsnMetPheValIleAlaGly202530GlyThrLeuAlaIleProIleLeuAlaPheValAlaSerPheLeuLeu354045TrpProSerAlaLeuIleArgIleTyrTyrTrpTyrTrpArgArgThr505560LeuGlyMetGlnValArgTyrAlaHisHisGluAspTyrGlnPheCys65707580TyrSerPheArgGlyArgProGlyHisLysProSerIleLeuMetLeu859095HisGlyPheSerAlaHisLysGlyHisValAlaGlnArgGlyGlnVal100105110ProSerArgLysAsnLeuHisPheGlyCysVal115120<210>180<211>120<212>蛋白质<213>小鼠<220><221>不确定<222>(5)...(5)<400>180AlaArgArgArgXaaArgTrpArgArgGlyCysCysTrpLeuIleGly151015ThrGlyLeuArgAlaAlaThrTrpThrValLeuCysSerProAsnSer202530SerLeuValValAlaArgHisThrLysSerPheProProLysLysPro354045LeuGlnAlaLeuThrMetSerIleMetAspHisSerProThrThrGly505560ValValThrValIleValIleLeuIleAlaIleAlaAlaLeuGlyGly65707580LeuIleLeuGlyCysTrpCysTyrLeuArgLeuGlnArgIleSerGln859095SerGluAspGluGluSerIleValGlyAspGlyGluThrLysGluPro100105110PheTyrTrpCysSerThrLeuLeu115120<210>181<211>60<212>蛋白质<213>小鼠<400>181LysGlyProGluValSerCysCysIleLysTyrPheIlePheGlyPhe151015AsnValIlePheTrpPheLeuGlyIleThrPheLeuGlyIleGlyLeu202530TrpAlaTrpAsnGluLysGlyValLeuSerAsnIleSerSerIleThr354045AspLeuGlyGlyPheAspProValTrpLeuPheLeu505560<210>182<211>72<212>蛋白质<213>小鼠<220><400>182LysProThrValGlySerAlaGluValAlaIleAlaValPh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euMetGlnArgCysTrpHisAlaAspPro260265270GlnValArgProThrPheGlnGluIleThrSerGluThrGluAspLeu275280285CysGluLysProAspGluGluValLysAspLeuAlaHisGluProGly290295300GluLysSerSerLeuGluSerLysSerGluAlaArgProGluSerSer305310315320ArgLeuLysArgAlaSerAlaProProPheAspAsnAspCysSerLeu325330335SerGluLeuLeuSerGlnLeuAspSerGlyIlePheProArgLeuLeu340345350LysGlyProGluGluLeuSerArgSerSerSerGluCysLysLeuPro355360365SerSerSerSerGlyLysArgLeuSerGlyValSerSerValAspSer370375380AlaPheSerSerArgGlySerLeuSerLeuSerPheGluArgGluAla385390395400SerThrGlyAspLeuGlyProThrAspIleGlnLysLysLysLeuVal405410415AspAlaIleIleSerGlyAspThrSerArgLeuMetLysIleLeuGln420425430ProGlnAspValAspLeuValLeuAspSerSerAlaSerLeuLeuHis435440445LeuAlaValGluAlaGlyGlnGluGluCysValLysTrpLeuLeuLeu450455460AsnAsnAlaAsnProAsnLeuThrAsnArgLysGlySerThrProLeu465470475480HisMetAlaValGluArgLysGlyArgGlyIleValGluLeuLeuLeu485490495AlaArgLysThrSerValAsnAlaLysAspGluAspGlnTrpThrAla500505510LeuHisPheAlaAlaGlnAsnGlyAspGluGlyGlnHisLysAlaAla515520525AlaArgGluGluCysPheCysGln530535<210>186<211>337<212>蛋白质<213>大鼠<220><400>186ArgPheGlyTyrGlnMetAspGluGlyAsnGlnCysValAsp151015ValAspGluCysAlaThrAspSerHisGlnCysAsnProThrGlnIle202530CysIleAsnThrGluGlyGlyTyrThrCysSerCysThrAspGlyTyr354045TrpLeuLeuGluGlyGlnCysLeuAspIleAspGluCysArgTyrGly505560TyrCysGlnGlnLeuCysAlaAsnValProGlySerTyrSerCysThr65707580CysAsnProGlyPheThrLeuAsnAspAspGlyArgSerCysGlnAsp859095ValAsnGluCysGluThrGluAsnProCysValGlnThrCysValAsn100105110ThrTyrGlySerPheIleCysArgCysAspProGlyTyrGluLeuGlu115120125GluAspGlyIleHisCysSerAspMetAspGluCysSerPheSerGlu130135140PheLeuCysGlnHisGluCysValAsnGlnProGlySerTyrPheCys145150155160SerCysProProGlyTyrValLeuLeuGluAspAsnArgSerCysGln165170175AspIleAsnGluCysGluHisArgAsnHisThrCysThrProLeuGln180185190ThrCysTyrAsnLeuGlnGlyGlyPheLysCysIleAspProIleVal195200205CysGluGluProTyrLeuLeuIleGlyAspAsnArgCysMetCysPro210215220AlaGluAsnThrGlyCysArgAspGlnProPheThrIleLeuPheArg225230235240AspMetAspValValSerGlyArgSerValProAlaAspIlePheGln245250255MetGlnAlaThrThrArgTyrProGlyAlaTyrTyrIlePheGlnIle260265270LysSerGlyAsnGluGlyArgGluPheTyrMetArgGlnThrGlyPro275280285IleSerAlaThrLeuValMetThrArgProIleLysGlyProArgAsp290295300IleGlnLeuAspLeuGluMetIleThrValAsnThrValIleAsnPhe305310315320ArgGlySerSerValIleArgLeuArgIleTyrValSerGlnTyrPro325330335Phe<210>187<211>152<212>蛋白质<213>小鼠<400>187MetAlaLeuGlyValLeuIleAlaValCysLeuLeuPheLysAlaMet151015LysAlaAlaLeuSerGluGluAlaGluValIleProProSerThrAla202530GlnGlnSerAsnTrpThrPheAsnAsnThrGluAlaAspTyrIleGlu354045GluProValAlaLeuLysPheSerHisProCysLeuGluAspHisAsn505560SerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuLysGln65707580AlaIleCysArgCysPheThrGlyTyrThrGlyGlnArgCysGluHis859095LeuThrLeuThrSerTyrAlaValAspSerTyrGluLysTyrIleAla100105110IleGlyIleGlyValGlyLeuLeuIleSerAlaPheLeuAlaValPhe115120125TyrCysTyrIleArgLysArgCysIleAsnLeuLysSerProTyrIle130135140IleCysSerGlyGlySerProLeu145150<210>188<211>118<212>蛋白质<213>大鼠<220><400>188LeuValProGlnPheGlyThrArgIleArgTyrThrAlaTyrAspArg151015AlaTyrAsnArgAlaSerCysLysPheIleValLysValGlnValArg202530ArgCysProIleLeuLysProProGlnHisGlyTyrLeuThrCysSer354045SerAlaGlyAspAsnTyrGlyAlaIleCysGluTyrHisCysAspGly505560GlyTyrGluArgGlnGlyThrProSerArgValCysGlnSerSerArg65707580GlnTrpSerGlySerProProValCysThrProMetLysIleAsnVal859095AsnValAsnSerAlaAlaGlyLeuLeuAspGlnPheTyrGluLysGln100105110ArgLeuLeuIleValSer115<210>189<211>299<212>蛋白质<213>人<220><400>189MetGlyThrLysAlaGlnValGluArgLysLeuLeuCysLeuPheIle151015LeuAlaIleLeuLeuCysSerLeuAlaLeuGlySerValThrValHis202530SerSerGluProGluValArgIleProGluAsnAsnProValLysLeu354045SerCysAlaTyrSerGlyPheSerSerProArgValGluTrpLysPhe505560AspGlnGlyAspThrThrArgLeuValCysTyrAsnAsnLysIleThr65707580AlaSerTyrGluAspArgValThrPheLeuProThrGlyIleThrPhe859095LysSerValThrArgGluAspThrGlyThrTyrThrCysMetValSer100105110GluGluGlyGlyAsnSerTyrGlyGluValLysValLysLeuIleVal115120125LeuValProProSerLysProThrValAsnIleProSerSerAlaThr130135140IleGlyAsnArgAlaValLeuThrCysSerGluGlnAspGlySerPro145150155160ProSerGluTyrThrTrpPheLysAspGlyIleValMetProThrAsn165170175ProLysSerThrArgAlaPheSerAsnSerSerTyrValLeuAsnPro180185190ThrThrGlyGluLeuValPheAspProLeuSerAlaSerAspThrGly195200205GluTyrSerCysGluAlaArgAsnGlyTyrGlyThrProMetThrSer210215220AsnAlaValArgMetGluAlaValGluArgAsnValGlyValIleVal225230235240AlaAlaValLeuValThrLeuIleLeuLeuGlyIleLeuValPheGly245250255IleTrpPheAlaTyrSerArgGlyHisPheAspArgThrLysLysGly260265270ThrSerSerLysLysValIleTyrSerGlnProSerAlaArgSerGlu275280285GlyGluPheLysGlnThrSerSerPheLeuVal290295<210>190<211>91<212>蛋白质<213>人<400>190GlnProThrValPheTrpProLysThrSerAlaLysLysGlyAsnTrp151015ValLeuArgLeuGlyLeuSerAsnProAspArgProAlaArgGlnAsn202530AsnTrpPheLeuProAlaSerArgGluIleProGluHisSerAlaLeu354045ThrArgTyrProAlaGlnIleArgGlyCysTrpProHisArgLeuThr505560LysProGlnThrCysLeuProGlnAlaArgSerTyrLeuSerHisGlu65707580ValThrGlnAlaThrArgThrCysProGlyGly8590<210>191<211>89<212>蛋白质<213>小鼠<400>191GlyAlaTrpAlaMetLeuTyrGlyValSerMetLeuCysValLeuAsp151015LeuGlyGlnProSerValValGluGluProGlyCysGlyProGlyLys202530ValGlnAsnGlySerGlyAsnAsnThrArgCysCysSerLeuTyrAla354045ProGlyLysGluAspCysProLysGluArgCysIleCysValThrPro505560GluTyrHisCysGlyAspProGlnCysLysIleCysLysHisTyrPro65707580CysGlnProGlyGlnArgValGluVal85<210>192<211>299<212>蛋白质<213>小鼠<220><400>192AlaArgAlaGlyAlaCysTyrCysProAlaGlyPheLeuGlyAlaAsp151015CysSerLeuAlaCysProGlnGlyArgPheGlyProSerCysAlaHis202530ValCysThrCysGlyGlnGlyAlaAlaCysAspProValSerGlyThr354045CysIleCysProProGlyLysThrGlyGlyHisCysGluArgGlyCys505560ProGlnAspArgPheGlyLysGlyCysGluHisLysCysAlaCysArg65707580AsnGlyGlyLeuCysHisAlaThrAsnGlySerCysSerCysProLeu859095GlyTrpMetGlyProHisCysGluHisAlaCysProAlaGlyArgTyr100105110GlyAlaAlaCysLeuLeuGluCysSerCysGlnAsnAsnGlySerCys115120125GluProThrSerGlyAlaCysLeuCysGlyProGlyPheTyrGlyGln130135140AlaCysGluAspThrCysProAlaGlyPheHisGlySerGlyCysGln145150155160ArgValCysGluCysGlnGlnGlyAlaProCysAspProValSerGly165170175ArgCysLeuCysProAlaGlyPheArgGlyGlnPheCysGluArgGly180185190CysLysProGlyPhePheGlyAspGlyCysLeuGlnGlnCysAsnCys195200205ProThrGlyValProCysAspProIleSerGlyLeuCysLeuCysPro210215220ProGlyArgAlaGlyThrThrCysAspLeuAspCysArgArgGlyArg225230235240PheGlyProGlyCysAlaLeuArgCysAspCysGlyGlyGlyAlaAsp245250255CysAspProIleSerGlyGlnCysHisCysValAspSerTyrThrGly260265270ProThrCysArgGluValProThrGlnLeuSerSerIleArgProAla275280285ProGlnHisSerSerSerLysAlaMetLysHis290295<210>193<211>314<212>蛋白质<213>小鼠<220><400>193GluGluProCysAsnAsnGlySerGluIleLeuAlaTyrAsnIleAsp151015LeuGlyAspSerCysIleThrValGlyAsnThrThrThrHisValMet202530LysAsnLeuLeuProGluThrThrTyrArgIleArgIleGlnAlaIle354045AsnGluIleGlyValGlyProPheSerGlnPheIleLysAlaLysThr505560ArgProLeuProProSerProProArgLeuGluCysAlaAlaSerGly65707580ProGlnSerLeuLysLeuLysTrpGlyAspSerAsnSerLysThrHis859095AlaAlaGlyAspMetValTyrThrLeuGlnLeuGluAspArgAsnLys100105110ArgPheIleSerIleTyrArgGlyProSerHisThrTyrLysValGln115120125ArgLeuThrGluPheThrCysTyrSerPheArgIleGlnAlaMetSer130135140GluAlaGlyGluGlyProTyrSerGluThrTyrThrPheSerThrThr145150155160LysSerValProProThrLeuLysAlaProArgValThrGlnLeuGlu165170175GlyAsnSerCysGluIlePheTrpGluThrValProProMetArgGly180185190AspProValSerTyrValLeuGlnValLeuValGlyArgAspSerGlu195200205TyrLysGlnValTyrLysGlyGluGluAlaThrPheGlnIleSerGly210215220LeuGlnSerAsnThrAspTyrArgPheArgValCysAlaCysArgArg225230235240CysValAspThrSerGlnGluLeuSerGlyAlaPheSerProSerAla245250255AlaPheMetLeuGlnGlnArgGluValMetLeuThrGlyAspLeuGly260265270GlyMetGluGluAlaLysMetLysGlyMetMetProThrAspGluGln275280285PheAlaAlaLeuIleValLeuGlyPheAlaThrLeuSerIleLeuPhe290295300AlaPheIleLeuGlnTyrPheLeuMetLys305310<210>194<211>109<212>蛋白质<213>小鼠<400>194GlyThrArgValGlyThrProTyrTyrMetSerProGluArgIleHis151015GluAsnGlyTyrAsnPheLysSerAspIleTrpSerLeuGlyCysLeu202530LeuTyrGluMetAlaAlaLeuGlnSerProPheTyrGlyAspLysMet354045AsnLeuTyrSerLeuCysLysLysIleGluGlnCysAspTyrProPro505560LeuProSerAspHisTyrSerGluGluLeuArgGlnLeuValAsnIle65707580CysIleAsnProAspProGluLysArgProAspIleAlaTyrValTyr859095AspValAlaLysArgMetHisAlaCysThrAlaSerThr100105<210>195<211>237<212>蛋白质<213>小鼠<400>195MetLeuSerLeuArgSerLeuLeuProHisLeuGlyLeuPheLeuCys151015LeuAlaLeuHisLeuSerProSerLeuSerAlaSerAspAsnGlySer202530CysValValLeuAspAsnIleTyrThrSerAspIleLeuGluIleSer354045ThrMetAlaAsnValSerGlyGlyAspValThrTyrThrValThrVal505560ProValAsnAspSerValSerAlaValIleLeuLysAlaValLysGlu65707580AspAspSerProValGlyThrTrpSerGlyThrTyrGluLysCysAsn859095AspSerSerValTyrTyrAsnLeuThrSerGlnSerGlnSerValPhe100105110GlnThrAsnTrpThrValProThrSerGluAspValThrLysValAsn115120125LeuGlnValLeuIleValValAsnArgThrAlaSerLysSerSerVal130135140LysMetGluGlnValGlnProSerAlaSerThrProIleProGluSer145150155160SerGluThrSerGlnThrIleAsnThrThrProThrValAsnThrAla165170175LysThrThrAlaLysAspThrAlaAsnThrThrAlaValThrThrAla180185190AsnThrThrAlaAsnThrThrAlaValThrThrAlaLysThrThrAla195200205LysSerLeuAlaIleArgThrLeuGlySerProLeuAlaGlyAlaLeu210215220HisIleLeuLeuValPheLeuIleSerLysLeuLeuPhe225230235<210>196<211>154<212>蛋白质<213>人<400>196MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnGlyAsnTrpThrValAsnLysThrGluAlaHisAsnIle354045GluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGluAspHis505560AsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuGlu65707580LysAlaIleCysArgCysPheThrGlyTyrThrGlyGluArgCysGlu859095HisLeuThrLeuThrSerTyrAlaValAspSerTyrGluLysTyrIle100105110AlaIleGlyIleGlyValGlyLeuLeuLeuSerGlyPheLeuValIle115120125PheTyrCysTyrIleArgLysArgCysLeuLysLeuLysSerProTyr130135140AsnValCysSerGlyGluArgArgProLeu145150<210>197<211>171<212>蛋白质<213>大鼠<400>197MetAlaArgProAlaProTrpTrpTrpLeuArgProLeuAlaAlaLeu151015AlaLeuAlaLeuAlaLeuValArgValProSerAlaArgAlaGlyGln202530MetProArgProAlaGluArgGlyProProValArgLeuPheThrGlu354045GluGluLeuAlaArgTyrSerGlyGluGluGluAspGlnProIleTyr505560LeuAlaValLysGlyValValPheAspValThrSerGlyLysGluPhe65707580TyrGlyArgGlyAlaProTyrAsnAlaLeuAlaGlyLysAspSerSer859095ArgGlyValAlaLysMetSerLeuAspProAlaAspLeuThrHisAsp100105110IleSerGlyLeuThrAlaLysGluLeuGluAlaLeuAspAspIlePhe115120125SerLysValTyrLysAlaLysTyrProIleValGlyTyrThrAlaArg130135140ArgIleLeuAsnGluAspGlySerProAsnLeuAspPheLysProGlu145150155160AspGlnProHisPheAspIleLysAspGluPhe165170<210>198<211>1399<212>DNA<213>小鼠<400>198ggcaaagacttcggcacgagasaacagcaaagcagagctggctgcagccattcactggcc60tcgggcgggcgtgccacagaggcagttgaagtgaaagtgaaagagaaacgataagagaac120ggagaccacaggtgctaagtgagggtgctcacagaaccccctcttcagccagagatcact180agcaggggaactgtggagaaggcagccagcaaggaagagcctgagagtagcctccatggg240cttggagcccagctggtatctgctgctctgtttggctgtctctggggcagcagggactga300ccctcccacagcgcccaccacagcagaaagacagcggcagcccacggacatcatcttaga360ctgcttcttggtgacagaagacaggcaccgcggggcttttgccagcagtggggacaggga420gagggccttgcttgtgctgaagcaggtaccagtgctggatgatggctccctggaaggcat480cacagatttccaggggagcactgagaccaaacaggattcacctgttatctttgaggcctc540agtggacttggtacagattccccaggcagaggcgttgctccatgctgactgcagcgggaa600ggcagtgacctgcgagatctccaagtatttcctccaggccagacaagaggccacttttga660gaaagcacattggttcatcagcaacatgcaggtttctagaggtggccccagtgtctccat720ggtgatgaagactctaagagatgctgaagttggagctgtccggcaccctacactgaacct780acctctgagtgcccagggcacagtgaagactcaagtggagttccaggtgacatcagagac840ccaaaccctgaaccacctgctggggtcctctgtctccctgcactgcagtttctccatggc900accagacctggacctcactggcgtggagtggcggctgcagcataaaggcagcggccagct960ggtgtacagctggaagacagggcaggggcaggccaagcgcaagggcgctacactggagcc1020tgaggagctactcagggctggaaacgcctctctcaccttacccaacctcactctaaagga1080tgaggggacctacatctgccagatctccacctctctgtatcaagctcaacagatcatgcc1140acttaacatcctggctccccccaaagtacaactgcacttggcaaacaaggatcctctgcc1200ttccctcgtctgcagcattgccggctactatcctctggatgtgggagtgacgtggattcg1260agaggagctgggtggaattccagcccaagtctctggtgcctccttctccagcctcaggca1320gagcacgatgggaacctacagcatttcttccacggtgatggctgacccaggccccacagg1380tgccacttatacctgccaa1399<210>199<211>469<212>DNA<213>大鼠<400>199ggggcgctggccagtcatggcggagccttgggctgggcagtttctgcaagctttgcccgc60cacggtgctcggagcgctgggcaccctgggcagcgagtttctgcgggagtgggagacaca120agatatgcgagtgactctcttcaagcttctcctgctttggttggtgttaagtctcctggg180catccagctggcgtgggggttctacgggaacacagtgaccgggttgtatcaccgtccagg240gaaatggcagcaaatgaagctctcaaaactcacagagaataaaggaaggcagcaggagaa300gggtctccagagatatcgctgggtctgctggctcctgtgctgtaccttgctgctatccag360accccttaggcaactgcagagggcttgggttgggggactggagtaccatgatgctcccag420ggtgagcctccactgccctcagccttgcctccaacagcgtcaggtactg469<210>200<211>529<212>DNA<213>大鼠<400>200aaagcttccatcctcaacatgccactagtgacgacactcttctacgcctgcttctatcac60tacacggagtccgaggggaccttcagcagtccagtcaacctgaagaaaacattcaagatc120ccagacagacagtatgtgctgacagccttggctgcgcgggccaagcttagagcctggaat180gatgtcgacgccttgttcaccacaaagaactggttgggttacaccaagaagagagcaccc240attggcttccatcgagttgtggaaattttgcacaagaacagtgcccctgtccagatattg300caggaatatgtcaatctggtggaagatgtggacacaaagttgaacttagccactaagttc360aagtgccatgatgttgtcattgatacttgccgagacctgaaggatcgtcaacagttgctt420gcatacaggagcaaagtagataaaggatctgctgaggaagagaaaatcgatgtcatcctc480agcagctcgcaaattcgatggaagaactaaggttcttttgctacccaga529<210>201<211>1230<212>DNA<213>大鼠<400>201aagaattcggcacgaggccatggctggttgggcgggggccgagctctcggtcctgaaccc60gctgcgtgcgctgtggctgttgctggccgccgccttcctgctcgcactgctgctgcagct120ggcgcccgccaggctgctaccgagctgcgcgctcttccaggacctcatccgctacgggaa180gaccaagcagtccggctcgcggcgccccgccgtctgcagggccttcgacgtccccaagag240gtacttttctcacttctacgtcgtctcagtgttatggaatggctccctgctctggttcct300gtctcagtctctgttcctgggagcgccgtttccaagctggctttgggctttgctcagaac360tcttggggtcacgcagttccaagccctggggatggagtccaaggcttctcggatacaagc420aggcgagctggctctgtctaccttcttagtgttggtgttcctctgggtccatagtcttcg480gagactcttcgagtgcttctacgtcagcgtcttctctaacacggccattcacgtcgtgca540gtactgtttcgggctggtctactatgtccttgttggcctgaccgtactgagccaagtgcc600catgaatgacaagaacgtgtacgctctggggaagaatctactgctacaagctcggtggtt660ccacatcttgggaatgatgatgttcttctggtcctctgcccatcagtataagtgccacgt720cattctcagcaatctcaggagaaataagaaaggtgtggtcatccactgccagcacagaat780cccctttggagactggttcgagtatgtgtcttctgctaactacctagcagagctgatgat840ctacatctccatggctgtcaccttcgggctccacaacgtaacctggtggctggtggtgac900ctatgtcttcttcagccaagccttgtctgcgttcttcaaccacaggttctacaaaagcac960atttgtgtcctacccaaagcataggaaagctttcctcccgttcttgttttgaacaggctt1020tatggtgaagagcgcagcccaggtgacaggttcccttcctcgagacgctgagacaggctg1080aagtacactttctgcagctggcgcccgccaggctgctaccgagctgcgcgctcttccagg1140acctcatccgctacgggaagaccaagcagtccggctcgcggcgccccgccgtctgcagcc1200cgggggatccactagttctagagcgccgcc1230<210>202<211>778<212>DNA<213>大鼠<400>202ctgcaggtcgacactagtggatccaaagattcggcacgagataaggcacatttgcttcat60aaaataaaaaaaaaggaaatttacttagccgcatgtcagtcacccaaattttgagtgtac120aaatgaaatggaaaacatttattacacaaatttaattacaattctagggaataaacatgc180aaatcagatggagctcaatctgcaggcgctgatcctctccccctggtttgcagtctgtgc240acctcctggattcgcccgcgaccaggcagtcagaggcctggctcttgcaggcaggaggat300cactgttgtaaagaacagcgtcacatttagcgcatctggcgtagtagcagtttttaacac360tttgcgcaggtgcctcccttcccccacccgcgctttgttaggtctacctctctaaatctc420tgccttcctcgcacagtaagtgacctctccatgacaaagggcccccagacagcagttata480aatcaatgtgttttgggtttgtttgtttgtttgttttgttttaaagaaaaacccggccat540gcttggtggcacttgcctttaatagtagcgcttggtagacagaggcaagcggttctctgt600aagttcaaggccagcctggtctacacagtgagaccgggtctcaaaaacaaaacaacaaaa660aacaactcctattgaatccactacaggaagggggggcgcggatcactgtctgcaaactaa720agtgacttgagctcctgtcacagcctttccagcaagggcaagcttctttattagttat778<210>203<211>1123<212>DNA<213>大鼠<400>203gggccccccctcgagtcgacgktatcgataagcttgatatcgaattcctgcaggtcgaca60ctagtggatccaaagaattcggcacgagcctgaggcgactacggtgcgggtgccgggtgc120cgggtgcctacagcccccatcagcttccccggggagattctgccgatttgtcacgagcca180tgctcaggaggcagctcgtctggtggcacctgctggctttgcttttcctcccattttgcc240tgtgtcaagatgaatacatggagtctccacaagctggaggactgcccccagactgcagca300agtgttgccatggagattatggattccgtggttaccaagggccccctggacccccaggtc360ctcctggcattccaggaaaccatggaaacaatggaaataacggagccactggccacgaag420gggccaagggtgagaaaggagacaaaggcgacctggggcctcgaggggaacgggggcagc480atggccccaaaggatagaagggatacccaggggtgccaccagagctgcagattgcgttca540tggcttctctagcgactcacttcagcaatcagaacagtggcattatcttcagcagtgttg600agaccaacattggaaacttcttcgatgtcatgactggtagatttggggcccccgtatcag660gcgtgtatttcttcaccttcagcatgatgaagcatgaggacgtggaggaagtgtatgtgt720accttatgcacaatggtaacacggtgttcagcatgtacagctatgaaacaaagggaaaat780cagatacatccagcaaccatgcagtgctgaagttggccaaaggagatgaagtctggctaa840gaatgggcaacggtgccctccatggggaccaccagcgcttctctaccttcgcaggctttc900tgctttttgaaactaagtgatgaggaagtcaggatagctccatgctaagggcgatttgta960ggtgagctagggttgttaggatctgaggggtgttggagttgggcttctctatggagtatt1020taactgttacattggtcacactgctactcattctaatggcataccaattatgttggatac1080tttaggggctaggaagaatagaccacaaggtaatattcccaga1123<210>204<211>434<212>DNA<213>小鼠<400>204accaccaagcagatggaatgctggcacacccatgcacctgcatggcgtcacaggtggaag60attgttaaaaaattgacatcagaaatatttacagaaatagatacctgtttgaataaagtt120agagatgaaatttttgctaaacttcaaccgaagcttagatgcacattaggtgacatggaa180agtcctgtgtttgcacttcctgtactgttaaagcttgaaccccatgttgaaagcctcttt240acatattctttttcttggaattttgaatgttcccattgtggacaccagtaccaaaacagg300tgtgtgaagagtctggtcacctttaccaatattgttcctgagtggcatccactcaatgct360gcccattttggtccatgtaacagctgcaacagtaaatcacaaataagaaaaatggtgttg420gaaagagcgtcgcc434<210>205<211>783<212>DNA<213>小鼠<400>205aattcggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgct60ggttgcgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcc120catctggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagta180cttaagtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcag240cgtggatcaactcatggagctggccgggttgagctgtgccacggctattgccaaggctta300tccccccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaa360taacggaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaac420tatctattaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtca480gaaaatggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaaggga540aaccctagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgca600actcactttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagag660aagaagtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacag720taagggaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaa780aaa783<210>206<211>480<212>DNA<213>小鼠<400>206aaatgaaaactcttggarctcgcgcgcctgcaggtcgacactagtggatccaaagaattc60ggcacgagttaaggttttcagactttatttcatggtatttgacattgacacatactgagt120tagtaacaagataccatgcagctccctctagcctcggatcaccgaagcaggaagaaggtc180agactgcccccatcccagatttgcttagtttgtctcccaatgtgctggactttaaagaca240gggaatggagaagcagatggatgcttcagtttcagtcatttttggctctatagtgatctc300tgccttcctgtacctgtccttggctggaccctgggcagtaactgtcactcagatgaggac360gatcatcattacaatggaccaactgagggatgccctcatattagaccaattaaaagttgc420tgtgagttaaaccaggaatgaccgcacttccacatcagaaatcaaacaaaatcaatggtt480<210>207<211>501<212>DNA<213>小鼠<400>207ctgcaggtcgacactagtggatccaaagaattcggcacgagaatcatggcgccgtcgctg60tggaaggggcttgtaggtgtcgggctttttgccctagcccacgctgccttttcagctgcg120cagcatcgttcttatatgcgactaacagaaaaggaagatgaatcattaccaatagatata180gttcttcagacacttctggcctttgcagttacctgttatggcatagttcatatcgcaggg240gagttcaaagacatggatgccacttcagaattaaagaataagacatttgataccttaagg300aatcacccatctttttatgtgtttaaccatcgtggtcgagtgctgttccggccttcagat360gcaacaaattcttcaaacctagatgcattgtcctctaatacatcgttgaagttacgaaag420tttgactcactgcgccgttaagctttttacaaattaaataacaggacagacacagaattg480agtattggagtttggggtgta501<210>208<211>480<212>DNA<213>小鼠<400>208ggcacgaggaagcctcttcccatggaagcacactctaggagagagaaggcctctgggctc60cgcctggcctggcattatgaatgcagtggggtcagtgtgtggtggatgtgtgtactgggt120tggctttcctttttagtttttttactttttagtttagtttgttcttttccttccccaata180aatcattctcacatgcttccatgtttgtttctgagaggtgggggctcaaatgtatagaaa240gtaggccccagtccataaggaggtgtgaacacacccccttactgcttatcacccatttga300caggaacgcccaggaggggagggggaggggaagaggtgagttctgcacagtcggacattt360ctgttgcttttgcatgtttaatatagacgttcctgtcgatccttgggagatcatggcctt420cagatatgcacacgacctttgaattgtgcctactaattatagcaggggacttgggtaccc480<210>209<211>962<212>DNA<213>小鼠<400>209ggcacgagattagcggctcctcagcccagcaaatcctccactcatcatgcttcctcctgc60cattcatctctctctcattcccctgctctgcatcctgatgagaaactgtttggcttttaa120aaatgatgccacagaaatcctttattcacatgtggttaaacctgtcccggcacaccccag180cagcaacagcaccctgaatcaagccaggaatggaggcaggcatttcagtagcactggact240ggatcgaaacagtcgagttcaagtgggctgcagggaactgcggtccaccaaatacatttc300ggacggccagtgcaccagcatcagccctctgaaggagctggtgtgcgcgggcgagtgctt360gcccctgccggtgcttcccaactggatcggaggaggctacggaacaaagtactggagccg420gaggagctctcaggagtggcggtgtgtcaacgacaagacgcgcacccagaggatccagct480gcagtgtcaggacggcagcacgcgcacctacaaaatcaccgtggtcacggcgtgcaagtg540caagaggtacacccgtcagcacaacgagtccagccacaactttgaaagcgtgtcgccagc600caagcccgcccagcaccacagagagcggaagagagccagcaaatccagcaagcacagtct660gagctagacctggactgactaggaagcatctgctacccagatttgattgcttggaagact720ctctctcgagcctgccattgctctttcctcacttgaaagtatatgctttctgctttgatc780aagcccagcaggctgtccttctctgggactagcttttcctttgcaagtgtctcaagatgt840aatgagtggtttgcagtgaaagccaggcatcctgtagtttccatcccctcccccatccca900gtcatttctttaaaagcacctgatgctgcattctgttacagtttaaaaaaaaaaaaaaaa960aa962<210>210<211>778<212>DNA<213>小鼠<400>210ggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttg60cgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatct120ggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaa180gtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtgg240atcaactcatggagctggccgggttgagctgtgccacggctattgccaaggcttatcccc300ccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacg360gaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatct420attaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaa480tggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccc540tagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgcaactca600ctttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaa660gtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagg720gaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaa778<210>211<211>1152<212>DNA<213>小鼠<400>211ggcacgagcttctcagggcctgccacccaaataagtctggccctagcctcaactctctct60caggctgggccacaggaagctgctgactggccacttgacaccctccccctaaagctaatg120tctgtgactatagggaggttagcactttttctaattggaattcttctctgtcctgtggcc180ccatccctcacccgctcttggcctggaccagatacatgcagcctctttctccagcacagc240ctttccctgagcctgaggttagggcagagtttagagggtgggctaagtgtatgttttcat300gtatgcattcatgcctgtgagtgtgtggcttgctgtcgtgtcctctgggatcccaagcca360cgcgggtcttccctctgtagatgggtcctgggttctatcacctgcttatttatgtacgag420gttggggggtggacccagggtgggttgattgtctctttgtaaggaagtatgtgtcggggg480tgacacgaggctaagcccgagaaaccccgggagacagcactgcataagaaactggtttcc540magactgcagagggagctgcacttttgttttgaccaaaaacaaaaaacaaaacaaaacaa600aaacaaaacaaaaataactctgaagggcgggaggatacccaagcctgatgcctgagagga660gtccctagacttcagcaactccgctgcgtggcctgagcccagcgggagggatggggagag720aattttttggagtccgtgcctgtggtgggcagtcctgagccttcagctgaagcagtgctt780tttggctgccctcacctcgcactacttgaccttgaggctctgagtatctcctgtgcacag840gagaagctcctgcaccagaaagcaccaaarsccmtggcaccccatcttactccactctcc900ccagggactcccaggtgggaactgctgtggcagtgagctcagcccggacagacactgcca960accctgtctcctggcattgggctccggctctacctccccaagcagggcgaggccccgcct1020tctcagcctagcaccacctgtccccgagtcttctcagcttgcccatcattctcggcgccc1080acacaggtgacagtcccaagtagataacctccatgggacaagttgggtgttgccttaccc1140gcctgcccagcc1152<210>212<211>446<212>DNA<213>小鼠<400>212ggcacgagcttgagtctggagtgctgcaaataatagtatgcactatccctgcctggcatg60tttgtttgttaatgtgcactggtgttttgcctggatgtgtatacttgtgaagatgtcaga120actcctggagctggagttagagacaatggtgagctgccttgtggatgttgggaattgaac180ccaggtcctctggagaaataaccagtgctcttaaccactaagccatctcaacagccccaa240attatttttttaataagttgcctcggtcatgttgtcttaatcagagcgatagaaaagtaa300ctaatatagattatttatgaattcaggtggcttaatggtatatgcatgaattagtagtaa360aacaagaactagggccagcaagtggcttaagggtgcctgctaaccatctcagccacctga420gttcagtctccaggaaccacacagtg446<210>213<211>2728<212>DNA<213>小鼠<400>213ggggagggagggccctgttttggcggagcagggcgcgcggctgggcccctgaagtggagc60gagagggaggcgcttcgccgggtgccactgccggggaggctcgtcgggacccagcgccgg120tcgcggctccctcaggatcgatgcaccgcggttaacccgtgaggaggcggcggccgggga180agatggtgttgccgacagtgttaattctgctcctctcctgggcggcggggctgggaggtg240agacacgaccccgggcggcgacggagcggcggtcggtcgggccgagcgcacgtcgcggag300ccgggccgcgcgtgtcaggtctcctcggcttctgtcagctctctcagctcgcctcagccg360accccgagcgacgctccccgcgcgctattgtccctcgcgcgccccgaccgcgctcccgcc420ggcggccctgcctgcccggcttctcgcgccgctttccccgggagcggcggagcccaggcc480agccgccctcgcgcactccgcagccacctcagccctgccggggtccgagccccgggaccg540cgcagactcgcagcaacttgcgaggttggcagcgcggcgggagcattgttctgcaagcga600gcgagcggacccgggccgggtgtcggacgccggtgtgcgtgtcccacccgagtgccttcc660ctccgcctcgtgctcttttcggagtgtttgtagccagcgcgccggaggttgtgtgtgtgt720gtgtgtctgtcgttctgtctgtctgtcttctgtctccccggggcaagactttagttgact780gaggagaagggcaagccgttttaggatgctcttcgatccatctgtctttttgagttgagt840ccacagagaagcaagaccgacccttcctgggcgaaccaacttgcagagttttcttaaact900ctcaggtggagcagacgtactgcttagtcagaggattgtcagggctgtgctccctccccc960tgcaaattggagttcactgttgcttcaagtttcctgatgcttcgggtttgagacagcggt1020atttcattcccaggctttcctaggacaggttgcatgattattttgttcctatgagaaagt1080gctttaccataggtaagctaatttgccgcccaagtgtctggagagaggttagcttaaaag1140cattgaattggaaacaacccccagaacttccaggggtgcttcggatggttgtcagcagcc1200taatttgatactttagaaaatatcctagtgttttctgtagtgtattgtctgtgttcatcc1260ctttgtctcattgacttaaactgcaggacccagcctatttttgtctggcattctgcttac1320tctgaagttggttttgtgtactcagtttctgttgttgtgtgtactattcatttattaagt1380acacattttagatgacagccactaatagatgcttatttttgttttgtttttgttttttgt1440tttttttaagaaccagattgcagaccgtttgtaaagagcctctttatttaacatttgtat1500ttctgtaacacggcttatagtcctggctggctgttttcactttttgtgattatggtcagg1560aattagacactgttctctatgaggtaataaaatctaagttaaatgtgatacactttgata1620acgtagtgatacaaaatgccttttattaaggaaaactaaaaccaatgtggcctgttgttt1680ggggaaaaaagtaaattaacagcataagcattgtgggtgaagagttttattcagatcttt1740ggagtttctttctgcactaagtaatgattcaaaggccaggttttgttgtgcttctgctaa1800aaacttaaaaaaaaaaataaaagttttcacttaagtattatgtcaaatttgtaatacttg1860agtatgtaggtatatttataatttggggctgtggaatgtagcccagtggcaattgcctag1920caaggccatgcaaggctttggattcaacatctctgtttaaggcccaaaactcctcctatg1980tttatttgtaactcattatactatatgctgggttttttttttttatctgaactgaatcgc2040atatagctaagtttatatatttttgtgatgttttgtaggctagtgtgcattcaaacttag2100tagatattggctgtagtgcattggaaagttgaaatgtttgtaaggttagggtagttgtag2160aaatacagaactttaaggtataagccatgttcaggtgaaactaaactctgttggttgctt2220tcatcttgcctgtttgtgttaatcactgttgtgtgtgaatgtttttcttactgcacataa2280tgtgaggggtgggaagctggaaggaggcaataaagtgcttaaatactaaaacaacttttc2340tagttttcccttctatgttggtggatgtcctgcccagtgttgtatttgtagaaagatacc2400atgatagtttttgagtttatgaagtgtctgtatggaagtattcatatatctgtacaaaat2460gcttctaaaaagttatttgttgcctagcaaaatggctcagtaggtgggagcacttgcttt2520gaaagcctgactatctgatttctagtccccatccctttagttgaaggagagaaccaactc2580ctgaaaattatcttttgaccttcacatgcacaccatggttcctcgtgcccttactcacac2640atgtacactacacacaattataagataataaagttatttggagacgtgttaggaacttat2700tggcactatcctgattagccacaatttt2728<210>214<211>2046<212>DNA<213>大鼠<400>214cggtatcgataagcttgatatcgaattcctgcaggtcgacactagtggatccaaagaatt60cggcacgagaaaataaccaaccaaacaaactttcctcttcccgctagaaaaaacaaattc120tttaaggatggagctgctctactggtgtttgctgtgcctcctgttaccactcacctccag180gacccagaagctgcccaccagagatgaggaactttttcagatgcagatccgggataaggc240attgtttcacgattcatccgtgattccagatggagctgaaatcagcagttacctatttag300agatacacctagaaggtatttcttcatggttgaggaagataacaccccactgtcagtcac360agtgacaccttgtgatgcgcctttggaatggaagcttagcctccaggagctgcctgagga420gtccagtgcagatgggtcaggtgacccagaaccacttgaccagcagaagcagcagatgac480tgatgtggagggcacagaactgttctcctacaagggcaatgatgtagagtattttctgtc540ttcaagttccccatctggtttgtatcagttggagcttctttcaacagagaaagacacaca600tttcaaagtatatgccaccaccactccagaatctgatcaaccataccctgacttaccata660tgaccccagagttgatgtgacctctattggacgtaccacagtcactttggcctggaagca720aagccccacagcttctatgctgaaacaacccatagagtactgtgtggtcatcaacaagga780gcacaatttcaaaagcctttgtgcagcagaaacaaaaatgagtgcagatgatgccttcat840ggtggcgcccaaacctggcctagactttagcccctttgactttgcccatttcggatttcc900aacagataatttgggtaaggatcgcagcttcctggcaaagccttctcccaaagtggggcg960ccatgtctactggaggcctaaggttgacataaaaaaaatctgcataggaagtaaaaatat1020tttcacagtctccgacctgaagcccaatacccagtactactttgatgtcttcatggtcaa1080taccaacactaacatgaacacagcttttgtgggtgcctttgccaggaccaaggaggaggc1140aaaacagaagacagtggagctcaaagatgggagggtcacagatgtggtcgttaaaaggaa1200agggaaaaagtttctacggtttgctccagtctcctctcaccaaaaagtcaccctctttat1260tcactcttgtatggacactgttcaagtccaagtgagaagagatgggaagctgcttctgtc1320acagaatgtggaaggcattcggcagttccagttaagaggaaaacccaaaggaaagtacct1380cattcgactgaaaggcaacaagaaaggagcatcaatgttgaaaatactagccaccaccag1440gcccagtaagcacgcattcccctctcttcctgatgacacaagaatcaaagcctttgacaa1500gctacgcacttgctcttcagtcacggtggcttggcttggcacccaagagaggagaaagtt1560ttgtatctacagaaaggaagtgggtggaaactacagtgaagagcagaagagaagagagag1620aaaccagtgcctaggaccagacaccagaaagaagtcagagaaggttctttgcaagtactt1680ccacagccaaaacctgcagaaagcagtgacgacagagacaatcagagatctgcaacctgg1740caagtcttacctactggacgtttatgttgtaggacatgggggacactctgtgaagtatca1800gagtaaacttgtgaaaacaaggaaggtctgttagttaccttaagtgaagatcagtagaac1860tcccggagagatatggaatcacactgcctgttactgactactctcatgacaaacagaagt1920tgtacttgaaagaaaggataacaacatgtgtacattgatgcctgtgtaatgtaacgtgga1980gacttgtattcacgcacacctgtggtacttagggtccatctgtctaatgctggctaatgt2040caaagg2046<210>215<211>493<212>DNA<213>小鼠<400>215cccacccagcagaagatcctctaccaatgaatgctgactgagcctgcccaactttttgtg60cacaagaagaaccagccaccttcacacagcagcctccggcttcactttaggaccctagca120ggagcactggccctttcttcaacacagatgagttggggactacagattctcccctgcctg180agcctaatccttcttctttggaaccaagtgccagggcttgagggtcaagagttccgattt240gggtcttgccaagtgacaggggtggttctcccagaactgtgggaggccttctggactgtg300aagaacactgtgcaaactcaggatgacatcacaagcatccggctgttgaagccgcaggtt360ctgcggaatgtctcggtaatcagatgggaaggggatagctagctctctaagaggggctga420tgggagtcgttcccttctgctctgatccctatacaggacaaggctgagcatgaggcaaag480tggtctctgtctg493<210>216<211>511<212>DNA<213>小鼠<400>216gggcatagtgctggagtagatgagaattctatgtcatgttcccaaggcaaccaggagaag60attgtcttccaggtagcttggagaagggtctcagagtgatgcatttcctccaatgcccac120tccaacagggctatttccctggccaagcatattcaaaccaccacagtgactaaaggccaa180gtggatggatgtctggtctgggttgccactggagaccttgtggatatatgaggctgtgct240gccttggctgctgatggggcaggggcatgcctgggtctgtggtcctattgcactctgggt300ctttgttaatgtcccaggcttatgttaccaccaaaagccattcagatgcccctggtctgg360attgctgcccgaagcactgtgctagccctgcctcttgctgaccaccacactcagaagagc420tgtccctacctcttgcctgggcagcacaatagagctgaccctgatgaagtggaagcactg480gtgaactggctccctccttcatctactgtag511<210>217<211>1107<212>DNA<213>大鼠<400>217cggcatctcaagctgctgcaagcaggactgagcactaccagagcagcaacctcggatggc60cctggacgtggcacgcgcggggcacagaggcaagaagacttgatgaagcctctcttccca120acccatatccagaaagaacgatttagatgacagtttttagaaaggtgaccaccatgatct180cctggatgctcttggcctgtgcccttccgtgtgctgctgacccaatgcttggtgcctttg240ctcgcagggacttccagaagggtggtcctcaactggtgtgcagtctgcctggtccccaag300gcccacctggccctccaggagcaccaggatcctcaggaatggtgggaagaatgggttttc360ctggtaaggatggccaagacggccaggacggagaccgaggggacagtggagaagaaggtc420cacctggcaggacaggcaaccgaggaaaacaaggaccaaagggcaaagctggggccattg480ggagagcgggtcctcgaggacccaagggggtcagtggtacccccgggaaacatggtatac540cgggcaagaagggacctaagggcaagaaaggggaacctgggctcccaggcccctgtagct600gcggcagtagccgagccaagtcggccttttcggtggcggtaaccaagagttacccacgtg660agcgactgcccatcaagtttgacaagattctgatgaatgagggaggccactacaatgcat720ccagtggcaagttcgtctgcagcgtgccagggatctattactttacctatgacattacgc780tggccaacaaacacctggccatcggcctagtgcacaatggccagtaccgcattcggactt840ttgacgccaacaccggcaaccacgacgtggcctcgggctccaccatcctagctctcaagg900agggtgatgaagtctggttacagattttctactcggagcagaatggactcttctacgacc960cttattggaccgacagcctgttcaccggcttcctcatctacgctgatcaaggagacccca1020atgaggtatagacaagctggggttgagccgtccaggcagggactaagattccgcaagggt1080gctgatagaagaggatctctgaactga1107<210>218<211>1001<212>DNA<213>大鼠<400>218ggagcaagaagcaacccgaagctaggagtctgtcagcgagggcaggggctgcctggttgg60ggtaggagtgggagcagggccagcaggagggtctgaggaagccattcaaagcgagcagct120gggagagctggggagccgggaagggcctacagactacaagagaggatcctggcgtctggg180cctcctgggtcatcaccatgaggccacttcttgccctgctgcttctgggtctggcatcag240gctctcctcctctggacgacaacaagatccccagcctgtgtcccgggcagcccggcctcc300caggcacaccaggccaccacggcagccaaggcctgcctggccgtgacggccgtgatggcc360gcgacggtgcacccggagctccgggagagaaaggcgagggcgggagaccgggactacctg420ggccacgtggggagcccgggccgcgtggagaggcaggacctgtgggggctatcgggcctg480cgggggagtgctcggtgcccccacgatcagccttcagtgccaagcgatcagagagccggg540tacctccgccagccgacacacccctacccttcgaccgtgtgctgctcaatgagcagggac600attacgatgccactaccggcaagttcacctgccaagtgcctggtgtctactactttgctg660tccatgccactgtctaccgggccagcctacagtttgatcttgtcaaaaatggccaatcca720tagcttctttcttccagttttttggggggtggccaaagccagcctcgctctcagggggtg780cgatggtgaggctagaacctgaggaccaggtatgggttcaggtgggtgtgggtgattaca840ttggcatctatgccagcatcaaaacagacagtaccttctctggatttctcgtctattctg900actggcacagctccccagtcttcgcttaaaatacagtgaacccggagctggcacttgctc960ctagtggagggtgtgacattggtccagcgcgcataccagga1001<210>219<211>2206<212>DNA<213>大鼠<400>219gtttcgtcttaacgccctctctgcgttggcagaactggccgtgggctcccgctggtacca60tggaacatctcagcccacacagactaagcggagactgatgttggtggcgttcctcggagc120atccgcggtgactgcaagtaccggtctcctgtggaagaaggctcacgcagaatctccacc180gagcgtcaacagcaagaagactgacgctggagataaggggaagagcaaggacacccggga240agtgtccagccatgaaggaagcgctgcagacactgcggccgagccttacccagaggagaa300gaagaagaagcgttctggattcagagacagaaaagtaatggagtatgagaataggatccg360agcctactccacaccagacaaaatcttccggtattttgccaccttgaaagtaatcaacga420acctggtgaaactgaagtgttcatgaccccacaggactttgtgcgctccataacacccaa480tgagaagcagccagaacacttgggcctggatcagtacataataaagcgcttcgatggaaa540gaaaattgcccaggaacgagaaaagtttgctgacgaaggcagcatcttctatacccttgg600agagtgtggactcatctccttctctgactacatcttcctcacaacggtgctctccactcc660tcagagaaatttcgaaattgccttcaagatgtttgacttgaatggagatggagaagtaga720catggaggagtttgagcaggttcaaagcatcattcgctcccagaccagcatgggcatgcg780tcacagagatcgtccaactactgggaacaccctcaagtctggcttatgttcggccctcac840gacctacttttttggagctgatctcaaagggaaactgaccattaaaaacttcctggaatt900tcagcgtaaactgcagcatgacgttctaaagctggagtttgaacgccatgacccggtaga960cgggagaatctctgagaggcagttcggtggcatgctgctggcctacagtggagtgcagtc1020caagaagctgaccgccatgcagaggcagctgaagaagcacttcaaggatgggaagggcct1080gactttccaggaggtggagaacttcttcactttcctgaagaacattaatgacgtggacac1140tgcgttaagcttttaccacatggctggagcatccctcgataaagtgaccatgcagcaagt1200ggccaggacagtggcgaaagtcgagctgtcggaccacgtgtgtgacgtggtgtttgcact1260ctttgactgcgacggcaatggggagctgagcaataaggagtttgtctccatcatgaagca1320gcggctgatgagaggcctggagaagcccaaggacatgggctttacccgtctcatgcaggc1380catgtggaaatgtgcccaagaaaccgcctgggactttgctctacccaaatagtaccccac1440ctcctgcaccttagcaccccgcaatcctggagtggccttcatgctgctgatgcttctggg1500agtagtgcccacatccccatctttctggaagtgacctctggcctcagctggctgacctct1560ccatcctcccctgacccagtcagtgttccgctaggctctgaatctgcagtcagatcaaag1620gtctaagacaggaacaagtcttcaaagcagagaccatagctcccttaaccagtgccccgt1680gggtaaatgcggggagccctcccacactggcagccccaggaggcatctctgcagtctctc1740actgtggatttaagtaacacaaacgtccctgccatcttcctcccactgttttaaagctgc1800aagtttggaaatactctggcaggcaaagggaagtctgtgatgaacggtaatgcagatgac1860cctggtaccctgatctggcagggcacctggtcaggggaagggtctgcgtcagacaccagc1920ggcaccaggaaggctctttgccaccagcacagctcccgattcaaagtcgctgctttgagc1980ggctctccagaacctcctgctcttttttttttcctcccggctccctgcgatgcctcctct2040gggactctgcttcactagagccagggctgagcccctgttccttgtgtcttgtcccctctc2100tatagacctgcagagcgcagctcagagcctatctgccctctgtctaatacactcgtaaat2160atcactttaattatagcactttgcaggaaataccccaaaaaaaaaa2206<210>220<211>376<212>DNA<213>人<400>220atcggcatcaccttctacaacaagtggctgacaaagagcttccatttccccctcttcatg60acgatgctgcacctggccgtgatcttcctcttctccgccctgtccagggcgctggttcag120tgctccagccacagggcccgtgtggtgctgagctgggccgactacctcagaagagtggct180cccacagctctggcgacggcgcttgacgtgggcttgtccaactggagcttcctgtatgtc240accgtctcgctgtgagtactggccatgccctgctgcctcccttcaggctgaagctgtctg300tctgtccagcggggtgtctgcacacccggctgctaggccagccactccaccactctggga360ccagcccttgctctct376<210>221<211>433<212>DNA<213>人<400>221agcttcttctcagagcaaacagtaagcaacagaaaatatacatttgatgaaacattcttt60gcattagagaaacatgaaaataaatataattcaaggaagtataatgattctctaatatgt120ctttctcagacctgtactagtttaccggttcaagaagctctcatcacatttttcacttgt180attttacatattgctattcgggtaattcaaataaaatgcaggtcttgtaaaagaataaaa240acattgacaagtatgcatgtgccagggaccaaattagagggttctttggtgcagttagtc300caaattctcagatttgaaggataatatgtaccaataaaaaaaaaatctgctgctagacat360ttacagcagtgctctgtcttgcttcacattagaaatcgaaaacagctgttctcaacaagc420caattttattttt433<210>222<211>530<212>DNA<213>人<400>222gtttcaagcctgtaatcatagcgttgggaatgctaaggcagaatcccatagttgagggca60gcctgagttagatagagaaacactgccaaactcaaaaatattcagtctgaggatgactta120atattgactttgtaagaagtatactcttggaaataggtgctaagcaaatagtgtttggga180cctctaagcttatgtgaccggagttttactcttttgtccttaattttctcattttctttt240gactggtgaaaagttgcagtgtaagttagaatttggctcgaagcctgcttccttagttga300atgccctgtgttttgtttttttttttttttttgagcacttcaaaaagtatgatatatagt360tccttaatgttaggactctatataccttcagaggcatgtgtgttgggattgaaattcaaa420ttctgatcatgtgaaaatggcactagttgttagaggaagtctctccttcaatctcagcat480ttacttacatactaactgaagagaaaatcacgtctcctagttctttgtaa530<210>223<211>550<212>DNA<213>小鼠<400>223aagctgctggttttaaatatttactttcccaggaggtgggtttcttcaggtgtttgttta60aagagggctgtcacaggtgaatggtttggggaacccttcttggcagagttttagctgcct120tactgaacattgtcccaacagaaagttcctatcgttctccttccttcttggcaggcttca180ggttttgctgcagcccctggagccaacattttggttgtgggaggctgacctcttgcctgc240ctccttgtgtggacagagtggtgaagacgtattcctcacctccttgcctttcagtaaatg300gccacgatgtgactatttgttgaggtttccagcctcttccaagaccttgccaggctgagt360ggggcctgagagcttgcaggcacttaaagcttcctggcaaaggggccggccacaggcaga420gggaaaggaacaggtcagaggcgttgctctggcagaggcggctcgggctgcccatcgtgt480ttctgcggggttgaggtgggctcccttctttgtagatgcctttcctctcgtaataacaac540tccttgcccc550<210>224<211>470<212>DNA<213>小鼠<400>224aggcctgttcaccaccactcctgttctccgctaagcttttctttggcttttggtggtttg60ttttttgttactgttattcaacagttcagcctaattataccatggcagagaacgagcctt120ttatgtttgggctgtgccactgaactgtttactgtagcgtgtgggtgaaggtggaactaa180tgggctcagtccttacctcctgcttctgtgtaggaggctcagccgaggcttggaactggc240taccttcagccagcagtcttttcccctgctgtatagcaacccttctacccttgcttttct300tgcttcctcatcttcactcaaccttaagcagagttcaaagactcaacttcaacattggtc360atctgggtgtgtatttatatgtgaataatgatatcagatccagagtaacacctttgctgt420cttcttaggatgggtgagtgcacggggctcgggctctttgctgaatactt470<210>225<211>1752<212>DNA<213>大鼠<400>225ggcacgagctgacatgaagccccctagacccagagattggttcctgctgtgacatgccta60ccatgtggccacttcttcatgtcctctggcttgctctggtctgtggctctgttcacacca120ccctgtcaaagtcagatgccaaaaaagctgcctcaaagacgctgctggaaaagactcagt180tttcggataaacctgtccaagaccggggtctggtggtgacggacatcaaagctgaggatg240tggttcttgaacatcgtagctactgctcagcaagggctcgggagagaaactttgctggag300aggtcctaggctatgtcactccatggaacagccatggctatgatgttgccaaggtctttg360ggagcaagttcacacagatctcaccagtctggttgcagctgaagagacgtggtcgggaga420tgtttgaaatcacaggcctccatgatgtggaccaagggtggatgcgagctgtcaagaagc480atgccaaaggcgtgcgcatagtgcctcggcttctgtttgaagactggacttacgatgatt540tccgaagcgtcctagacagtgaggatgagatagaagagctcagcaagactgtggtacagg600tggcaaagaaccagcattttgacggctttgtggtggaggtctggagccagttgctgagcc660agaaacatgtaggcctcattcacatgcttactcacttggctgaggcgctgcaccaggcca720ggctgctggtcattctggtcatcccacctgctgtcacccctgggactgaccagctgggca780tgtttacacacaaggagtttgagcagctggcccccatactagatggcttcagcctcatga840catacgactactccacatcacagcagcctggccctaatgctccattgtcatggatccgag900cctgtgttcaggtcctagaccccaagtcacagtggcgtagcaagatcctcctgggattga960acttctatggcatggattatgcagcctccaaggatgcccgtgagcctgtcattggagcca1020gggcagttttgaaggtggctctgccattggctgtctcatcccagcagatctggacattgg1080gaagaggagggtccaccagtgccctactcctggcaggcttggggctggcctcagagccct1140gtacaaagagcgaggaggttccaaagaagagcctcttagatacagtttggcactggcagg1200gagagccaggagcactgtgtagaggtcgtcttcacacctggatcctagtgagcgcggtcc1260cgcaggcctgcacatgcctgtttcagtgatggcctcacgaggcagcaccggctctagctg1320cactgctttctttgattagctttggccatgggagacacaggtagcagcatagcgggtcag1380gaacctcttgagcagatccaaccaaaggctttttgtcacttgccagctctgcatggtcag1440cctgtgacaccgtctcactcaaggccttctggagttggccctcagctcagatgtcatgtg1500agggataccctaaggagatgatggggctccctcttgcctgagcttgcaggattggatctt1560gggcagatcagggcagtggaaacgtcagaccttctacccgtacatacagacgctgaagga1620ccacaggccccgtgtggtatgggacagccaggctgcggaacacttctttgagtacaagaa1680gaatcgcggcgggaggcacgttgtcttctacccaacgctgaagtctctgcaggtgcggct1740ggagctagccag1752<210>226<211>2165<212>DNA<213>小鼠<400>226ggcacgagcctgctgccctcttgcagacaggaaagacatggtctctgcgcccggatccta60cagaagctcatggggagccccagactggcagccttgctcctgtctctcccgctactgctc120atcggcctcgctgtgtctgctcgggttgcctgcccctgcctgcggagttggaccagccac180tgtctcctggcctaccgtgtggataaacgttttgctggccttcagtggggctggttccct240ctcttggtgaggaaatctaaaagtcctcctaaatttgaagactattggaggcacaggaca300ccagcatccttccagaggaagctgctaggcagcccttccctgtctgaggaaagccatcga360atttccatcccctcctcagccatctcccacagaggccaacgcaccaaaagggcccagcct420tcagctgcagaaggaagagaacatctccctgaagcagggtcacaaaagtgtggaggacct480gaattctcctttgatttgctgcccgaggtgcaggctgttcgggtgactattcctgcaggc540cccaaggccagtgtgcgcctttgttatcagtgggcactggaatgtgaagacttgagtagc600ccttttgatacccagaaaattgtgtctggaggccacactgtagacctgccttatgaattc660cttctgccctgcatgtgcatagaggcctcctacctgcaagaggacactgtgaggcgcaaa720aagtgtcccttccagagctggcctgaagcttatggctcagacttctggcagtcaatacgc780ttcactgactacagccagcacaatcagatggtcatggctctgacactccgctgcccactg840aaactggaggcctccctctgctggaggcaggacccactcacaccctgcgaaacccttccc900aacgccacagcacaggagtcagaaggatggtatatcctggagaatgtggacttgcacccc960cagctctgctttaagttctcatttgaaaacagcagccacgttgaatgtccccaccagagt1020ggctctctcccatcctggactgtgagcatggatacccaggcccagcagctgacgcttcac1080ttttcttcgaggacatatgccaccttcagtgctgcctggagtgacccaggtttggggccg1140gatacccccatgcctcctgtgtacagcatcagccagacccagggctcagtcccagtgacg1200ctagacctcatcatccccttcctgaggcaggagaattgcatcctggtgtggaggtcagat1260gtccattttgcctggaagcacgtcttgtgtcctgatgacgccccttaccctactcagctg1320ttgctccggtccctaggctccggtcgaacaaggccagttttactcctacatgcagcggac1380tcagaggcacagcgacgcctggtgggagctttggccgaactgctgcggacggcgctggga1440ggtggacgcgacgtgatcgtggatctctgggaagggacgcacgtagcacgcattggacca1500ctgccgtggctttgggcagcgcgggagcgcgtggcgcgggagcagggcacagtgctgctc1560ctgtggaactgtgcgggtcccagcaccgcctgcagcggtgacccgcaggctgcgtccctt1620cgcaccttgttgtgcgctgctccacgtccgctgctgctcgcctacttcagtcgcctctgc1680gccaaaggtgacatcccccggccgctgcgcgctctgccacgctaccgcctgcttcgtgac1740ctgccgcgcctgctgagagcactggatgctcagcctgccaccctagcctccagctggagt1800caccttggggctaagcggtgcttgaaaaaccgtctggagcagtgtcacctgctggaactt1860gaggctgccaaagatgactaccaaggctcaaccaatagtccctgtggtttcagctgtctg1920tagcctcagcctgtgtagcaacagcaggaactccagaatgaggcctcacacatgtactct1980ttgggggtgcttcttgtcccccaaaccgtaagactcaccttaagtcccacacttgaccaa2040cctccctcacatttgctccctcttagagttcctgagaggaacttgggctttcctgatagg2100tcctcagccctttctgagaaggagggacgatttttccatttcttttcaaaactgaaaaaa2160aaaaa2165<210>227<211>1348<212>DNA<213>小鼠<220><221>不确定<222>(644)...(644)<400>227caaagaattcggcacgagaccggcctcactatgtctgccattttcaattttcagagtctg60ttgactgtaatcttgctgcttatatgtacatgtgcttatatccgatccctggcacccagc120atcctggacagaaataaaactggactattgggaatattttggaagtgtgcccgaattggg180gaacgcaagagtccttatgtcgccatatgctgtatagtgatggccttcagcatcctcttc240atacagtagctttggaaactaccagcatgtgcttgctatcagactgtaaacaaggacttg300cctccagaaaataatgggaagaatggttaagccatttgtctctgaacatggaatgagata360aacttcaagatgctgttctctatttttatgctattggaccaatgagctgaatgaataatt420aagatgtaacagttcaatacacaggaatgtgattgtatccatcaacctcagttctctcac480tccagtattacattctgcaaatgtcattctgttgtgtcaggactgcttttcataaggttc540ttcgggcacgaagtagaaacccagtggcaaattccaaggctcctttgactagggcttcaa600aataatgtcttcacagaatggtacctctagcgactgtcctattnttattgagaaaaaaac660ttgttctatttttgttgttgttactgttcttatggattgcattcatatttaaaccctttg720gattgctaaccagagtacctctattcttggcaaattccgcagtttattacaggtgtttaa780agtattttaaacaaaactctgaatttctttagttagcctaagagttggcttctagtcaca840aagatacagctgccacactgtgacgaagagcaccttagaaagaaaagcagcaagtgagcg900gtgagcaagtaagcaccgtgcagtcttcgtgcaagtaagcaccgtgcagtcttcgttctc960tgtagtcttgtcttccaaatagaacgtccatcgtagttacccaaaggtggtatttgtggt1020gttcttaatgcagtgctttaagtctagtgtatgttctgtcagcttgaactggaatctctc1080ttgtaactttgtaggttataaacatatctcatatctgctttagtctgggtactatgctct1140aagtacatttcagctttgacacagaatgtgaatagacgaatatcaaaggatacttacaag1200tttgtatccaacatttcttcaggttcagctgaaaatcagttactgtttcaaaacaaagag1260gaattaaatcctagctgaaaactatacatagcatttattaattaattactgggtttaact1320gctctttttaaaagtttgaaaaaaaaaa1348<210>228<211>2296<212>DNA<213>小鼠<220><221>不确定<222>(2255)...(2255)<400>228ctggagctcgcgcgcctgcaggtcgacactagtggatccaaagcttaaaagagactccac60ccactccagtagaccggggactaaaacagaaattctgagaaagcagcaagaagcagaaga120aatagctatttcacagcagtaacagaagctacctgctataataaagacctcaacactgct180gaccatgatcagcccagcctggagcctcttcctcatcgggactaaaattgggctgttctt240ccaagtggcacctctgtcagttgtggctaaatcctgtccatctgtatgtcgctgtgacgc300aggcttcatttactgtaacgatcgctctctgacatccattccagtgggaattccggagga360tgctacaacactctaccttcagaacaaccaaataaacaatgttgggattccttccgattt420gaagaacttgctgaaagtacaaagaatatacctataccacaacagtttagatgaattccc480taccaaccttccaaagtatgtcaaagagttacatttgcaagagaataacataaggactat540cacctatgattcactttcgaaaattccgtatctggaagagttacacttggatgataactc600agtctcggctgttagcatcgaagagggagcatttcgagacagtaactatctgcggctgct660ttttctgtcccgtaaccaccttagcacaatcccggggggcttgcccaggactattgagga720attacgcctggatgacaatcgcatatcaacgatctcttccccatcacttcatggtctcac780aagcctgaaacgcctggttttagatggaaacttgttgaacaaccatggtttgggtgacaa840agttttcttcaacttagtaaacttaacagagctgtccctggtgaggaattccttgacagc900agcgccagtgaaccttcccggcacaagcctgaggaagctttaccttcaagacaaccatat960caaccgggtacccccaaatgctttttcttatttaaggcagctgtatcgactcgatatgtc1020taataataacctaagcaatttacctcagggtatctttgatgatttggacaatataaccca1080actgattcttcgcaacaatccttggtattgtggatgcaagatgaaatgggtacgagactg1140gttacagtcgctaccggtgaaggtcaatgtgcgtgggctcatgtgccaagccccagaaaa1200ggtccgtggaatggctatcaaggacctcagtgcagaactgtttgattgtaaagacagtgg1260gattgtgagcaccattcagataaccactgcaatacccaacacagcatatcctgctcaagg1320acagtggccagctcctgtgaccaaacaaccagatattaaaaaccccaagctcattaagga1380tcagcgaactacaggcagcccctcacggaaaacaattttaattactgtgaaatctgtcac1440ccctgacacaatccacatatcctggagacttgctctgcctatgactgctctgcgactcag1500ctggcttaaactgggccatagcccagcctttggatctataacagaaacaatcgtaacagg1560agaacgcagtgaatacttggtcaccgccctagaacctgaatcaccctatagagtatgcat1620ggttcccatggaaaccagtaacctttacctgtttgatgaaacacctgtttgtattgagac1680ccaaactgcccctcttcgaatgtacaaccccacaaccaccctcaatcgagagcaagagaa1740agaaccttacaaaaatccaaatttacctttggctgccatcattggtggggctgtggccct1800ggtaagcatcgccctccttgctttggtgtgttggtatgtgcataggaacgggtcactgtt1860ttcacggaactgtgcgtacagcaaagggcggaggagaaaggatgactatgcagaagccgg1920tactaagaaagacaactccatcctggaaatcagggaaacttctttccagatgctaccgat1980aagcaatgaacccatctccaaggaggagtttgtaatacacaccatatttcctccgaatgg2040gatgaatctgtacaagaacaacctcagtgagagcagtagtaaccggagctacagagacag2100tggcatcccagactcggaccactcacactcatgatgcaaggaggtcccacaccagactgt2160tccgggtttttttttaaaaaacctaagaaaggtgatggtaggaactctgttctactgcaa2220aacactggaaaagagactgagagaagcaatgtacntgtacatttgccatataatttatat2280ttaagaactttttatt2296<210>229<211>1704<212>DNA<213>大鼠<220><400>229ccaaagaattcggcacgaggcggctcgggatggcggcccccatggaccggacccatggtg60gccgggcagcccgggcgctgcggcgggctctggcgctggcctcgctggccgggctattgc120tgagcggcctggcgggtgctctccccaccctcgggcccggctggcggcgccaaaaccccg180agccgccggcctcccgcacccgctcgctgctgctggacgccgcttcgggccagctgcgcc240tggagtacggcttccaccccgatgcggtggcctgggctaacctcaccaacgccatccgcg300agactgggtgggcctatctggacctgggcacaaatggcagctacaagtggatcccccggg360ctgcaggcctatgcagctggtgtggtggaggcctctgtgtccgaggagctcatctacatg420cactggatgaacacggtggtcaattactgcggccccttcgagtacgaagtcggctactgt480gagaagctcaagagcttcctggaggccaacctggagtggatgcagagggaaatggagctt540agcccggactcgccatactggcaccaggtgcggctgaccctcgggctgcagctgaagagg600cctggaggacagctatgaaggccgtttaaccttcccaactgggaggttcaacatcaaacc660cttggggttcctcctgctgcaggaatctctggagatctggaagacctagagacagccctg720aataagaccaacgaccaagcgcttccgtgggctccggttcgtgctctgccctcatcaagc780tgctgcccggcagccatgatctcctggtggctcacaacacttggaactcctaccagaaca840tgttacgcatcatcatggagtcccccgggctgcagttccgggaggggccgcaagaaggag900taccccctgattgccggcaacaacttgattttttcgtcttacccgggcaccatcttctcc960ggtgatgacttctacatcctgggcagtgggctggtcaccctggagaccaccaatcggcaa1020caaagaacccaagcgctgtggaagtacgtgcaaccccagggctgtgtgctggagtggatt1080cgaaacattgtggccaacccgcctggccttggatggggccacctgggcagatgtcttcag1140gcggttcaatagtggcacgtataataaccagtggatgattgtggactacaaggcattcat1200ccccaatgggcccagccctggaagccgggtgctcaccatcctagaacagatcccgggcat1260ggtggtggtggcatcccccgggctgcaggaattcgatatcaagcttatcgatacacgtcg1320aaccctcgagccaagatcttccagagggaccagtcactagtagaggacgtagacaccatg1380gtccggctcatgaggtacaatgacttccttcatgaccctctgtcgttgtgtgaggcctgc1440agcccgaagcccaacgcagagaacgccatctctgccccgctctgatctcaaccctgctaa1500ntggctcctacccatttcaggccctgcgtcagcgcgcccatggcggcattgatgtgaagg1560tgaccagcgttgcactggctaagtacatgagcatgctggcagccagtggccccacgtggg1620accagttgccaccgttccagtggagtaaatcaccattccacaacatgctgcacatgggcc1680aagcctgatctttggatgttctca1704<210>230<211>2004<212>DNA<213>大鼠<400>230ctcgaggtcgacggtatcgataagcttgattaattaaccctcactaaagggaacaaaagc60tggagctcgcgsgctgcaggtcgacactagtggatccaaagaattcggcacgaggcggaa120gcagccgcaggtatggcggctgccatgccgctgggtttatcgttgctgttgctggtgcta180gtggggcagggctgctgtggccgcgtggagggcccacgcgacagcctgcgagaggaactc240gttatcactccgctgccttccggcgacgtggccgccacattccagttccgcacgcgttgg300gattccgatctgcagcgggaaggagtgtcccattacaggctcttccctaaagccctggga360cagttgatctccaagtactctctgcgggagctacacctgtcattcacgcaaggcttttgg420aggacccgatactgggggccacccttcctgcaggctccatcaggtgcagagctctgggtc480tggttccaagacactgtcacagatgtggataagtcttggaaggagctcagtaatgtcctc540tcagggatcttctgcgcgtccctcaacttcatcgactccaccaataccgtcactcccaca600gcctccttcaaacctctggggctggccaatgacactgaccactacttcctgcgctatgct660gtgctgccccgggaggtcgtctgcaccgagaatctcacgccgtggaagaagctcctgccc720tgtagctccaaggcagggctgtccgtgctactgaaagcagatcgattgttccacaccagt780taccactcccaggcagtgcatatccggccaatctgcagaaatgctcactgcaccagtatc840tcctgggagctgaggcagaccctttcagttgtctttgatgccttcatcaccggacagggg900aagaaagactggtctctcttccgcatgttctcccggactctcacagaggcctgtccattg960gcatctcagagcctagtttatgtggacatcacaggctacagccaggacaacgaaacactg1020gaggtgagccctcccccaacttccacataccaggatgtcattttgggcaccaggaagacc1080tatgccgtctatgacttgtttgacacagccatgatcaataactcccgaaacctcaacatc1140cagctcaaatggaagagacccccagataatgaagccctgcccgtgcccttcctgcatgca1200cagcggtacgtgagtggttatgggctacagaagggcgagctgagcaccctgttgtacaac1260tctcatccttaccgggccttccctgtgctgctactggatgctgtgccctggtacctgcgg1320ctgtatgtgcacaccctcaccatcacctccaagggcaaggataataaaccaagttatatc1380cactaccagcctgcccaggaccggcagcagccccacctcctggagatgctcattcagctg1440ccggccaactccgtcaccaaggtctccatccagtttgaacgagccctgctcaagtggaca1500gaatacacgccagaccccaaccatggcttctatgtcagcccatctgtcctcagtgccctt1560gtgcccagcatggtggcagccaaaccagtggactgggaagagagccctctcttcaacacc1620ttgttcccggtgtctgatggctccagctactttgtccgactctacacagagcccttgcta1680gtgaacctgcccacccccgacttcagcatgccctacaatgtgatctgccttacatgcact1740gtggtggccgtgtgctatggctccttctacaatctcctcacccgaaccttccacattgaa1800gagcccaaatccggcggcctggccaagcggctggctaacctcatccggcgtgctcgtggt1860gttccccctctctaagattccctttcttcagcaactacagcttcatactcacctgcccca1920ggggagcagtggcagggctttttctgccatgccctctttccccagagttagcttctgaag1980ctaactccccctggatctggtctg2004<210>231<211>1397<212>DNA<213>大鼠<400>231cgggccccccctcgaggtcgacggtatcgataagcttgattaattaaccctcactaaagg60gaacaaaagctggagctcgcgcgcctgcaggtcgacactagtggatccaaagaattcggc120acgagcggcacgagcggccccgaagggggctgcacgggcgacttggcggcgatggctcga180gctccggcggcgacgacggtggccggaggcggcggctcctcctccttctcctcctgggct240tgggcccggcggtgatccgagctggcggccgcggccccccgatgagactgttggcgggct300ggctgtgcctgagcctggcgtccgtgtggctggcgcggaggatgtggacgctgcggagcc360cgctctcccgctctctgtacgtgaacatgactagcggccctggcgggccagcggcggcca420cgggcggcgggaaggacacgcaccagtggtatgtgtgcaacagagagaaattatgcgaat480cacttcagtctgtctttgttcagagttatcttgaccaaggaacacagatcttcttaaaca540acagcattgagaaatctggctggctatttatccaactctatcattcttttgtatcatctg600tttttagcctgtttatgtctagaacatctattaacgggttgctaggaagaggctccatgt660ttgtgttctcaccagatcagtttcagagactgcttaaaattaatccggactggaaaaccc720atagacttcttgatttaggtgctggagatggagaagtcacgaaaatcatgagccctcatt780ttgaagaaatttatgccactgaactttctgaaacaatgatctggcagctccagaagaaga840aatacagagtgcttggtataaatgaatggcagaatacagggttccagtatgatgtcatca900gctgcttaaatctgctggatcgctgtgatcagcctctgacattgttaaaagatatcagaa960gtgtcttggagcccacccaaggcagggtcatcctggccttggttttgccctttcatccct1020atgtggaaaacgtaggtggcaagtgggagaaaccatcagaaattctggaaatcaagggac1080agaattgggaagagcaagtgaatagcctgcctgaggtgttcaggaaagctggctttgtca1140tcgaagctttcactagactgccatacctgtgtgaaggtgacatgtacaatgactactatg1200ttctggacgacgctgtctttgttctcagaccagtgtaaacatgtggaggcccaagtcttc1260agagtcacccctggaatctgccctccagaagaggaggtgcatccagtgatgtgaggggga1320cctctggggactgtcattctcagtatcatgtaggaatttaaaaagccaaaatactaattc1380tttctttgtagtgtgta1397<210>232<211>861<212>DNA<213>大鼠<400>232gaattcggcacgagaggagagaaagagaagtgtgcacaaagaaacttgtattattattaa60ttagcacctagcttgtttgtgtctgatacaccaccaagtagtaattgttgaaaaaacgaa120gaagaaaaaaaaaaaacaaaaaaaccaaacagtgggtactcaaataagataggagaaaaa180tgagagaacagacccagttctcgacccttgcttctcaaggtcctcccaccaggctgccaa240agcaagatggtgttgctctgatccagtcagtattcttttgacttttttttttaatctcca300ggttttggttcaggctcccatattcataccctggctcatttagctttccctcatgttgtg360ggttcttctgtccctcacccccttactctccccactgatattcttcccagtcaagactgt420ggctctggaagaaatatccaccatttgcagagctgatgttctgtagatcgtaatgttgaa480gcgctgggtgtcctggttggcagaatcactcctgtattactctggtacataggtgtctcc540tgatagactccctggccttagtcatggggtgttttctagaggcagactaagacaggagtc600aaaaaagatttagaggaaggagctgaggaaagaaagacagttgtgggaggaaaatcaagt660tctactcaggatcccgagtgtttctgtagatgtagattggaatgtgtccataacagagag720gccagtgagagacatccccaaggacctgccaggctttccttcgctccaggaagacgcacc780atcactcaaaaggggtttcctagaaagaaagacaagtgacttaaaaaatctgccagtggg840ttcttgaagtcatcgaaccta861<210>233<211>445<212>DNA<213>小鼠<400>233ggaagtagaagggcccggcgttttcatggcggcgtcctgggggcaggtgcttgctctggt60gctggtggccgcactgtggggtggcacgcagccgctgctgaagcgagcctcctccggcct120ggagcaagtgcgtgagcggacgtgggcctggcagctgttgcaggagataaaggctctctt180cgggaatactgaggtgcgtctagctctcacggacgagcccctgaaaatttcaccataggt240cggccgtattcccagcccatctcttactcactagaagttcctggaagagtcatttatcct300cttacctgatgccctttctcctcaatcagagtggatcccttctctactacttgactttgg360catcaacagatctgacgttagctgtgcccatctgcaactctctggccatcgtctttacac420tgattgttgggaaggtccttggaga445<210>234<211>565<212>DNA<213>人<400>234cagcatcctcaatcaatccaacagcatattcggttgcatcttctacacactacagctatt60gttaggttgcctgcggacacgctgggcctctgtcctgatgctgctgagctccctggtgtc120tctcgctggttctgtctacctggcctggatcctgttcttcgtgctctatgatttctgcat180tgtttgtatcaccacctatgctatcaacgtgagcctgatgtggctcagtttccggaaggt240ccaagaaccccagggcaaggctaagaggcactgagccctcaacccaagccaggctgacct300ctgctttgctttggcatgtgagccttgcctaagggggcatatctgggtccctagaaggcc360ctagatgtggggcttctagattaccccctcctcctgccatacccgcacatgacaatggac420caaatgtgccacacgctcgctcttttttacacccagtgcctctgactctgtccccatggg480ctggtctccaaagctctttccattgcccagggagggaaggttctgagcaataaagtttct540tagatcaatcaaaaaaaaaaaaaaa565<210>235<211>476<212>DNA<213>人<400>235ggtggctttcattggtgctgtccccggcataggtccatctctgcagaagccatttcagga60gtacctggaggctcaacggcagaagcttcaccacaaaagcgaaatgggcacaccacaggg120agaaaactggttgtcctggatgtttgaaaagttggtcgttgtcatggtgtgttacttcat180cctatctatcattaactccatggcacaaagttatgccaaacgaatccagcagcggttgaa240ctcagaggagaaaactaaataagtagagaaagttttaaactgcagaaattggagtggatg300ggttctgccttaaattgggaggactccaagccgggaaggaaaattcccttttccaacctg360tatcaatttttacaacttttttcctgaaagcagtttagtccatactttgcactgacatac420tttttccttctgtgctaaggtaaggtatccaccctcgatgcaatccaccttgtttt476<210>236<211>607<212>DNA<213>人<400>236tatgtccactaacaatatgtcggacccacggaggccgaacaaagtgctgaggtacaagcc60cccgccgagcgaatgtaacccggccttggacgacccgacgcggactacatgaacctgctg120ggcatgatcttcagcatgtgcggcctcatgcttaagctgaagtggtgtgcttgggtcgct180gtctactgctccttcatcagctttgccaactctcggagctcggaggacacgaagcaaatg240atgagtagcttcatgctgtccatctctgccgtggtgatgtcctatctgcagaatcctcag300cccatgacgcccccatggtgataccagcctagaagggtcacattttggaccctgtctatc360cactaggcctgggctttggctgctaaacctgctgccttcagctgccatcctggacttccc420tgaatgaggccgtctcggtgcccccagctggatagagggaacctggccctttcctaggga480acaccctaggcttacccctcctgcctcccttcccctgcctgctgctgggggagatgctgt540ccatgtttctaggggtattcatttgctttctcgttgaaacctgttgttaataaagttttt600cactctg607<210>237<211>513<212>DNA<213>小鼠<400>237ttctccattacctctatgcctaatattcatcagccttcattactctctagcatattcacc60ttgattcaacagattcaaacttcctacagccttctactgatgtcttacaagctcttgcct120ctgtgcctttctcatgctattctttttgcttagattgctctttggtcccagctcatgttc180atcactcccttcaaagcctttcttcctttatatcttctgactgagctctccctgattgac240atcacctcatgcgatgacctccctcattctgtgctgcctcagcacttatcttttgagttt300gtactgtggtccatgtacttactaatatgttgctttgtaattattttctagcactctgtg360ttacagtttcatatttgtatttatttccaaaattaaattgtaagctccttgagggcagga420ataataacttttacatttgtatctctgcacccccgagtgcctagtatagtgctgagcaca480tagtaggcgtttaataaatgcttgttgaagtat513<210>238<211>944<212>DNA<213>大鼠<400>238ggcacgaggggccgccgagtcccgccgggtcggtgtagctcgctgccgacgctgcgacgc60tcgtgggtgccgtgttcggcttttcctgtctacttcagtgcaccgctgcagctccggcct120cgggtctgacgcgccacagcatggcttccgctttggaggagttgcagaaagacctagaag180aggtcaaagtgctgctggaaaagtccactaggaaaagactacgtgatactcttacaaatg240aaaaatccaagattgagacggaactaaggaacaagatgcagcagaagtcacagaagaaac300cagaatttgataatgaaaagccagctgctgtggttgctcctcttacaacagggtacactg360tgaaaatcagtaattatggatgggatcagtcagataagtttgtgaaaatctacattactt420taactggagttcatcaggttcctgctgagaatgtgcaagtacacttcacagagaggtcat480ttgatcttttggtaaaaaacctcaatggcaagaattactccatgattgtgaacaatcttt540tgaaacctatctctgtggaaagcagttcaaaaaaagtcaagactgatacagttattatcc600tatgtagaaagaaagcagaaaacacacgatgggactacttaactcaggtggaaaaagaat660gcaaagagaaagaaaagccttcctacgacactgaggcagatcctagtgagggattaatga720atgttctaaagaaaatttatgaagatggagatgatgacatgaagcgaaccattaataaag780cgtgggtggaatcccgagagaagcaagccagggaagacacagaattctgaggctttaaaa840gtcctgtgggaaccgtcatgtggagtgctcgtgtttccagtagggactgttggtgaactg900cacacatgtgttcatgtgggtatgtagttttggacagatgacta944<210>239<211>386<212>DNA<213>大鼠<400>239ctcgtgccgaattcggcacgagtggcgagatggggaatgcggccctgggagcggagctgg60gcgtgcgggtcctgctctttgtggccttcctggcgaccgagctgctccctcccttccagc120ggcggattcagcccgaggagctgtggctttaccggaacccgtacgtggaggcggaatact180tccccaccggccccatgtttgtcattgcctttctcaccccactgtccctgatcttcttcg240ccaagtttctgaggaaagctgacgccaccgacagcaagcaagcctgcctcgctgccagcc300ttgccctagctctgaatggtgtctttaccaacatcataaaactgatagtgggcaggccac360gcccagatttcttctaccgatgcttc386<210>240<211>228<212>DNA<213>大鼠<400>240ttccgcgggcgtcatgacggctgcggtgttctttggttgcgccttcatcgccttcgggcc60cgcgctctccctttacgtcttcaccatcgccactgatcctttgcgagtcatcttcctcat120cgccggtgccttcttctggttggtgtctctgctgctttcgtctgttttctggttcctagt180gagagtcatcactgacaacagagatggaccagtacagaattacctgct228<210>241<211>452<212>DNA<213>人<400>241ttcgagcggccgcccgggcaggttgaaactttagaaagaagagccgggaggatgtattgg60ttgttaggaaaatgtaggctaccagtagaaaatgacattctctattaataagatctgagg120tgcgacacacataattgtcccaatttttaagattgatggggagcatgaagcattttttta180atgtgttggcaggccccattaaatgcataaactgcataggactcatgtggtctgaatgta240ttttagggctttctgggaattgtcttgacagagaacctcagctggacaaagcagccttga300tctgagtgagctaactgacacaatgaaactgtcaggcatgtttctgctcctctctctggc360tcttttctgctttttaacaggtgtcttcagtcagggaggacaggttgactgtggtgagtc420caggacaccaaggcctactgcactcgggaacc452<210>242<211>1311<212>DNA<213>小鼠<400>242ctgcaacaaggctgttggttcctctccaatgggctccagtgaagggctcctgggcctggg60ccctgggcccaatggtcacagtcacctgctgaagaccccactgggtggccagaaacgcag120tttttcccacctgctgccctcacctgagcccagcccagagggcagctacgtgggccagca180ctcccagggcctcggcggccactacgcggactcctacctgaagcggaagaggattttcta240aggggtcgacaccagagatgctccaagggcctgcaccaagttgcttttgggttttttctg300gtatttgtgttttctgggattttatttttattattttttttaatgtcctttctttgggta360atagagaaatctctgcaaaagactttgctgaccaaccagctggagctcaaggaatgtggg420gtatctggggccacaccattacctgtgggcttgctcctggagccaaaccctgcagcctta480agagagaggggcctgacctgctctctttccctccctagctccaggcctcctctcctgcct540cgtcactcctgtgttctggcctcttgagtgcctttggaggtgtctctgacctgtgaggat600cagagacagtccccgtttttaaacttcgacaattgacttttatttccttttctaattttt660attattttttaaaacaaccaggatgattatcacatctactcccccatccgtccagaaaag720ccccaaattgattccttcagggtctggcctgcccaggctctattccacatgtgcaggttc780caacagcttaaccctattctcttcccagtcatctgctgcaggtatagctgtctcatgccc840ctgcctgcctattctggccagtaccctaagccccaagatctccagcccctgccccagtat900ccttgccttctgatgccttaaagttgggccacaggtcctgctgggtcagagcctcacaga960tgcggagctccaaaagctccgctcaggaccaaagagctctggcctagggttcatcctttc1020tccaggtgtctgccctgtggacagaaggctaaagccttgatcttggcaaaccaccccttt1080tgcccaaagcctggatgcagagaccagtattttctgctggcttcaacagtctcccctgct1140gtctgtgaaaggtgaccattgtacccaggccactgggcctctaccatgttctttcaaacc1200caggtcattaccatccccaggctggatcactggagcaggcctcctctctgtccatgtgag1260ggggacctaggggctctgcccttagccagctgagccaccaccagcctccct1311<210>243<211>399<212>DNA<213>小鼠<400>243aagggtcctgaagtcagttgttgcatcaaatacttcatttttggcttcaatgtcatattt60tggtttttgggaataacgtttcttggaatcggactgtgggcgtggaatgaaaaaggtgtc120ctctccaacatctcgtccatcaccgacctcggtggctttgacccagtgtggcttttcctc180tgagtggccagcccgagcctgagctctgtcaatgacatccaaggagaaaatgaggttaat240gagagacattaattaaacactccctcaccccaccgcaccaaaccagttgggttcttctga300tattctggaatactctgggctatgttttatgtttatttcttttttaatcggttgtatttt360ggtctttttttttcttcttctttttcttttgctcccaaa399<210>244<211>1421<212>DNA<213>小鼠<220><221>不确定<222>(1370)...(1370)<221>不确定<222>(1395)...(1395)<400>244gccgaggcgggcaggcaccagccagagcagctggcggcagacagtcggaccgagacagtt60ggaccgagacagtcgaacggtctaacagggcctggcttgcctacctggcagctgcacccg120gtccttttcccagagctggttctgtgggtcaacatggtcccctgcttcctcctgtctctg180ctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccctcccggcctccttc240ctggaggaagtggcgggcagtggggaagctgagggttcttcagcctcttccccaagcctg300ctgccgccccggactccagccttcagtcccacaccagggaggacccagcccacagctccg360gtcggccctgtgccacccaccaacctcctggatgggatcgtggacttcttccgccagtat420gtgatgctcattgcggtggtgggctcgctgacctttctcatcagttcatagtctgcgcgg480cactcatcacgcgccagaagcacaaggccacagcctactacccgtcctctttccccgaaa540agaagtatgtggaccagagagaccgggctggggggccccatgccttcagcgaggtccctg600acagggcacctgacagccggcaggaagagggcctggactcctcccagcagctccaggctg660acattctggctgctactcagaacctccggtctccagctagagccctgccaggcagtgggg720agggaacaaaacaggtgaagggtgggtcggaggaggaggaggagaaggaagaggaggtgt780tcagtggccaggaggagccccgggaagccccagtatgtggggtcactgaagagaagccgg840aggtccctgacgagacagcctcagcagaggctgaaggggttcccgcagccagcgagggcc900aaggggaaccagaagggtctttctccttagcccaggaaccccagggagcagctggtcctt960ccgaaaggtcctgtgcctgcaacagaatctcccctaatgtgtaacaggccccagaactgt1020gaggcctgactcttgggtcctcgaaggtcacctccttggtcaagaaaggcattcagcttt1080gactgcttcttgacaccctgccttggccattgtgggtgccaatcctgaccctgaatgggc1140aaagctgctggcctctggtgtaccccaggaaacaccaccccaagttccagcgcccttaat1200gactctcacatcctgggggcttcaccccgaagcaccacttttctggaaggggaaggtcag1260acacatcccagtttggagccgcaatgaggcagtcctcagaacagaaggggaacaggccag1320aggctgactgtgacatacacagtaaacacccctgcttgcaccttggctgnggagacaaga1380ggggctgttgatcanatggcctgcggtgtcctatctgccgt1421<210>245<211>461<212>DNA<213>小鼠<400>245cgcctgcaggtcgacactagtggatccaaagttctttttcttttctttttcttttttttg60tgtgtgtgtgttttggtttgttgttgttttggttttcctggaactcactctgtagaccag120gctagccccaaactcagaaatctgcctcccgagtgctgggactaagggtgtgcaccacca180ctgccctggtgcagatgactcctttaaggagctagagtaacccttgttcgcctcggtgag240agtctgagaatcaggcgctttggctacacagctcaatttacacagccaagcctttagctt300ctatgtgtgctgggcatggacagagcctcctcatcgccagtgatgatggccgggtttcca360ggcagccgtggtcctgtctgaatattgtctctaactgccacagtttcagagaaaggggaa420caagttctcctttgcttcttgccctcccagatagacccttg461<210>246<211>1280<212>DNA<213>小鼠<400>246ttggactcgcgcgcctgcaggtcgacactagtggatccaaagaattcggcacgagagaac60attcgagaatatgttcggtggatgatgtattggattgtctttgcgatcttcatggcagca120gaaaccttcacagacatcttcatttcctggtccggcccaaggattggcaggccatggggt180tgggaagggcctcaccaccaccaccacctggcctctggctcacacaaacccctccccttg240cttacacacaggttcccgttttattacgagttcaagatggcttttgtgctgtggctgctc300tcaccttacaccaagggggccagcctgctttaccgaaagtttgtccacccatccctatcc360cgccatgagaaggagatcgacgcatgtatcgtgcaggcaaaggagcgcagctatgaaacc420atgctcagttttgggaagcggagcctcaacatcgctgcctcagctgctgtgcaggctgct480accaagagtcaaggcgctctagctggaaggctacggagtttctctatgcaagacctgcgc540tctatccctgacacccctgtccccacctaccaagatcccctctacctggaagaccaggta600ccccgacgtagaccccctattggataccggccaggcggcctgcagggcagtgacacagag660gatgagtgttggtcagacaatgagattgtcccccagccacctgttgggccccgagagaag720cctctaggccgcagccagagccttcgggtggtcaagaggaagccattgactcgagagggc780acctcacgctccctgaaggtccgaaccccgaaaaaggccatgccctcagacatggacagc840tagagtctgcagattgaggccaccttacctctggagccagcaggggacctttcgctgcta900caccagctaccggggttctgctccgtctggcttgtgcctaaatggcacatggcgtggtac960cctgcacagggagacattcactgtaccaaagcagcccaggcctggggcctatttattgcc1020ttcctctgccttttgctttctcagacatgggaccagagccccaccagtccctaccgacga1080aaccaaaagtccaaccagctgtgttcattccttcttgtccttcaaaatacttgacagcct1140tttccaaggcctggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtttacg1200tacactagctgcatgtttcgtgttggtgagtgaggtcaggcttatgaatatttttatata1260aataaataccaaacagtgaa1280<210>247<211>833<212>DNA<213>大鼠<400>247gtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaaggttattctcctgg60ttcactggctgttgacaacctggggctgcttggcgttctcaggctcctatgcttggggca120acttcactatcctggccctgggtgtgtgggctgtggcccagcgggactctgttgatgcca180ttggcatgtttcttggtggcttggttgccaccatcttcctggacattatctacattagca240tcttctactcaagcgttgccgttggggacactggccgcttcagtgccggcatggccatct300tcagcttgctgctgaagcccttctcctgctgcctcgtctaccacatgcaccgggagcgag360ggggtgagctcccgctccgctcggatttcttcggaccttctcaggaacatagtgcctacc420agacaattgactcgtcagactcacctgcagacccccttgcaagcctggagaacaagggcc480aagctgccccccgggggtactgaagctgtccctggccgtcctggggcccagcaggatgct540tgtcaccttctttactggacctacaatggggtatcctccattccctgccacagaggtggc600ctgagtcatgtgccctcggaggtcccagctgagaagagcccagtcctaattctccatgct660gcccctccattcaagacacctgttaacccctgggctagaactgtggttggtttcttcccc720tcctccccatcactataacacacaaccgccgagctgtgcagagtgttcagggccatccag780gccttatgggccaatgatcactgcctctcaggctaccccaaggtgacccagcc833<210>248<211>1308<212>DNA<213>大鼠<400>248gccgaggcgggcaggcaccagccagagcagctggcggcagacagtcggaccgagacagtt60ggaccgagacagtcgaacggtctaacagggcctggcttgcctacctggcagctgcacccg120gtccttttcccagagctggttctgtgggtcaacatggtcccctgcttcctcctgtctctg180ctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccctcccggcctccttc240ctggaggaagtggcgggcagtggggaagctgagggttcttcagcctcttccccaagcctg300ctgccgccccggactccagccttcagtcccacaccagggaggacccagcccacagctccg360gtcggccctgtgccacccaccaaccttctggatgggatcgtggacttcttccgccagtat420gtgatgctcattgcggtggtgggctcgctgacctttctcatcatgttcatagtctgcgcg480gcactcatcacgcgccagaagcacaaggccacagcctactacccgtcctctttccccgaa540aagaagtatgtggaccagagagaccgggctggggggccccatgccttcagcgaggtccct600gacagggcacctgacagccggcaggaagagggcctggactcctcccagcagctccaggct660gacattctggctgctactcagaacctccggtctccagctagagccctgccaggcagtggg720gagggaacaaaacaggtgaagggtgggtcggaggaggaggaggagaaggaagaggaggtg780ttcagtggccaggaggagccccgggaagccccagtatgtggggtcactgaagagaagccg840gaggtccctgacgagacagcctcagcagaggctgaaggggttcccgcagccagcgagggc900caaggggaaccagaagggtctttctccttagcccaggaaccccagggagcagctggtcct960tccgaaaggtcctgtgcctgcaacagaatctcccctaatgtgtaacaggccccagaactg1020tgaggcctgactcttgggtcctcgaaggtcacctccttggtcaagaaaggcattcagctt1080tgactgcttcttgacaccctgccttggccattgtgggtgccaatcctgaccctgaatggg1140caaagctgctggcctctggtgtaccccaggaaacaccaccccaagttccagcgcccttaa1200tgactctcaccatcctgggggcttcaccccgaagcaccacttctctggaaggggaaggtc1260agacacatcccagttggagccgcaatgaggcagtcctcagaacagaag1308<210>249<211>1212<212>DNA<213>人<400>249tagcgtggtcgcggccgaggtactacagactttgtgataaggctgaagcttggggcatcg60tcctagaaacggtggccacagctggggttgtgacctcggtggccttcatgctcactctcc120cgatcctcgtctgcaaggtgcaggactccaacaggcgaaaaatgctgcctactcagtttc180tcttcctcctgggtgtgttgggcatctttggcctcaccttcgccttcatcatcggactgg240acgggagcacagggcccacacgcttcttcctctttgggatcctcttttccatctgcttct300cctgcctgctggctcatgctgtcagtctgaccaagctcgtccgggggaggaagccccttt360ccctgttggtgattctgggtctggccgtgggcttcagcctagtccaggatgttatcgcta420ttgaatatattgtcctgaccatgaataggaccaacgtcaatgtcttttctgagctttccg480ctcctcgtcgcaatgaagactttgtcctcctgctcacctacgtcctcttcttgatggcgc540tgaccttcctcatgtcctccttcaccttctgtggttccttcacgggctggaagagacatg600gggcccacatctacctcacgatgctcctctccattgccatctgggtggcctggatcaccc660tgctcatgcttcctgactttgaccgcaggtgggatgacaccatcctcagctccgccttgg720ctgccaatggctgggtgttcctgttggcttatgttagtcccgagttttggctgctcacaa780agcaacgaaaccccatggattatcctgttgaggatgctttctgtaaacctcaactcgtga840agaagagctatggtgtggagaacagagcctactctcaagaggaaatcactcaaggttttg900aagagacaggggacacgctctatgccccctattccacacattttcagctgcagaaccagc960ctccccaaaaggaattctccatcccacgggcccacgcttggccgagcccttacaaagact1020atgaagtaaagaaagagggcagctaactctgtcctgaagagtgggacaaatgcagccggg1080cggcagatctagcgggagctcaaagggatgtgggcgaaatcttgagtcttctgagaaaac1140tgtacctgcccgggcggccgctcgaaatcaagcttatcgataccgtcgacctcgaggggg1200ggcccggtacac1212<210>250<211>453<212>DNA<213>人<400>250aagaattccaaatgcttacttttctggtgcagaaagattgttgggaacagacaggaacca60atgtgggaattcaacttcaagttcaaaaaacagtcccctaggttaaagagcaagtgtaca120ggaggattgcagcctcccgttcagtacgaagatgttcataccaatccagaccaggactgc180tgcctactgcaggtcaccaccctcaatttcatctttattccgattgtcatgggaatgata240tttactctgtttactatcaatgtgagcacggacatgcggcatcatcgagtgagactggtg300ttccaagattcccctgtccatggtggtcggaaactgcgcagtgaacagggtgtgcaagtc360atcctggaccagtgcacagcgttcggctctttgactggtggcatcctcagtacccattct420ccctgagagcgtagttactgcttcccatccctt453<210>251<211>242<212>DNA<213>人<400>251gagagagagaactagtctcgagttttttgtatttttatttttgttcatctgctgctgttt60acattctggggggttagggggagtccccctccctccctttcccccccaagcacagagggg120agaggggccagggaagtggatgtctcctcccctcccaccccaccctgttgtagcccctcc180taccccctccccatccaggggctgtgtattattgtgagcgaataaacagagagacgctaa240ca242<210>252<211>358<212>DNA<213>人<400>252gatggccccagtcccaagttggccctgtggctgccctcaccagctcccacagcagcccca60acagccctgggggaggctggtcttgccgagcacagccagagggatgaccggtggctgctg120gtggcactcctggtgccaacgtgtgtctttttggtggtcctgcttgcactgggcatcgtg180tactgcacccgctgtggcccccatgcacccaacaagcgcatcactgactgctatcgctgg240gtcatccatgctgggagcaagagcccaacagaacccatgccccccaggggcagcctcaca300ggggtgcagacctgcagaaccagcgtgtgatggggtgcagacccccctcatggagtat358<210>253<211>568<212>DNA<213>人<400>253catctgtcatggcggctgggctgtttggtttgagcgctcgccgtcttttggcggcagcgg60cgacgcgagggctcccggccgcccgcgtccgctgggaatctagcttctccaggactgtgg120tcgccccgtccgctgtggcgggaaagcggcccccagaaccgaccacaccgtggcaagagg180acccagaacccgaggacgaaaacttgtatgagaagaacccagactcccatggttatgaca240aggaccccgttttggacgtctggaacatgcgacttgtcttcttctttggcgtctccatca300tcctggtccttggcagcacctttgtggcctatctgcctgactacaggatgaaagagtggt360cccgccgcgaagctgagaggcttgtgaaataccgagaggccaatggccttcccatcatgg420aatccaactgcttcgaccccagcaagatccagctgccagaggatgagtgaccagttgcta480agtggggctcaagaagcaccgccttccccaccccctgcctgccattctgacctcttctca540gagcacctaattaaaggggctgaaagtc568<210>254<211>1421<212>DNA<213>人<400>254gattagcgtggtcgcggccgaggtgtctgttcccaggagtccttcggcggctgttgtgtc60agtggcctgatcgcgatggggacaaaggcgcaagtcgagaggaaactgttgtgtctcttc120atattggcgatcctgttgtgctccctggcattgggcagtgttacagtgcactcttctgaa180cctgaagtcagaattcctgagaataatcctgtgaagttgtcctgtgcctactcgggcttt240tcttctccccgtgtggagtggaagtttgaccaaggagacaccaccagactcgtttgctat300aataacaagatcacagcttcctatgaggaccgggtgaccttcttgccaactggtatcacc360ttcaagtccgtgacacgggaagacactgggacatacacttgtatggtctctgaggaaggc420ggcaacagctatggggaggtcaaggtcaagctcatcgtgcttgtgcctccatccaagcct480acagttaacatcccctcctctgccaccattgggaaccgggcagtgctgacatgctcagaa540caagatggttccccaccttctgaatacacctggttcaaagatgggatagtgatgcctacg600aatcccaaaagcacccgtgccttcagcaactcttcctatgtcctgaatcccacaacagga660gagctggtctttgatcccctgtcagcctctgatactggagaatacagctgtgaggcacgg720aatgggtatgggacacccatgacttcaaatgctgtgcgcatggaagctgtggagcggaat780gtgggggtcatcgtggcagccgtccttgtaaccctgattctcctgggaatcttggttttt840ggcatctggtttgcctatagccgaggccactttgacagaacaaagaaagggacttcgagt900aagaaggtgatttacagccagcctagtgcccgaagtgaaagagaattcaaacagacctcg960tcattcctggtgtgagcctggtcggctcaccgcctatcatctgcatttgccttactcagg1020tgctaccggactctggcccctgatgtctgtagtttcacaggatgccttatttgtctttta1080caccccacagggccccctacttcttcggatgtgtttttaataatgtcagctatgtgcccc1140atcctccttcatgccctccctccctttcctaccactggtgagtggcctggaacttgttta1200aagtgtttattccccatttctttgagggatcaggaaggaatcctgggtatgccattgact1260tcccttctaagtagacagcaaaaatggcgggggtcgcaggaatctacactcaactgccca1320cctggctggcagggatctttgaataggtatcttgagcttggttctgggctctttccttgt1380gtacctgcccgggcggccgctcgaaatcaagcttatcgata1421<210>255<211>1464<212>DNA<213>小鼠<400>255ggcacgagcgggagcctgctactgccctgctgggttccttggggccgactgtagccttgc60ctgtccacagggtcgcttcggccccagctgtgcccacgtgtgtacatgcgggcaaggggc120ggcatgtgacccagtgtcggggacttgcatctgtcctcccgggaagacgggaggccattg180tgagcgcggctgtccccaggaccggtttggcaagggctgtgaacacaagtgtgcctgcag240gaatgggggcctgtgtcatgctaccaatggcagctgctcctgccccctgggctggatggg300gccacactgtgagcacgcctgccctgctgggcgctatggtgctgcctgcctcctggagtg360ttcctgtcagaacaatggcagctgtgagcccacctccggcgcttgcctctgtggccctgg420cttctatggtcaagcttgtgaagacacctgccctgccggcttccatggatctggttgcca480gagagtttgcgagtgtcaacagggcgctccctgtgaccctgtcagtggccggtgcctctg540ccctgctggcttccgtggccagttctgcgagagggggtgcaagccaggcttttttggaga600tggctgcctgcagcagtgtaactgccccacgggtgtgccctgtgatcccatcagcggcct660ctgcctttgcccaccagggcgcgcaggaaccacatgtgacctagattgcagaagaggccg720ctttgggccgggctgtgccctgcgctgtgattgtgggggtggggctgactgcgaccccat780cagtgggcagtgccactgtgtggacagctacacgggacccacttgccgggaagtgcccac840acagctgtcctctatcagaccagcaccccagcactccagcagcaaggccatgaagcacta900actcagaggaacgcccacagaggcccactactgtgttccagcccaagggacccaggcctc960tgctggtgactaagatagaggtggcacttttggatccacacctcttctggaaagccatgg1020attgctgtggacagctatggatagtcatatagccacacacccgggctccatggtcatggg1080gaagaaggcctcctttggacacaaggaatccaggaagtcggctgggcttcgggccactgt1140ttacatggggaccctgcaggctgtgctgtggaatcctggccctcttcagcgacctgggat1200gggaccaaggtgggaatagacaaggccccacctgcctgccaggtccttctggtgctaggc1260catggactgctgcagccagccaactgtttacctggaaatgtagtccagaccatatttata1320taaggtatttatgggcatctccacctgccgttatggtcctgggtcagatggaagctgcct1380gaccccagaacttaggcagtggcctgtggggtctccagcaagtggga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12>DNA<213>小鼠<400>263gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaagagcatgtccaggtaccggggccaggagcactgcct420gcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgagaa480gcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagttg540agagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagcat600aagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacattttata660gctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcatta720caagtggctttttgctgggcggttggcggggggcggggggacct764<210>264<211>1697<212>DNA<213>小鼠<400>264gcgcggcccgggggactcacattccccggtcccccctccgccccacgcggctgggccatg60gacgccagatggtgggcagtagtggtactcgccacactcccttccttgggagcaggtgga120gagtcacccgaagcccctccgcagtcctggacacagctgtggctcttccgcttcttgttg180aatgtagcgggctatgccagctttatggtacctggctacctcctggtgcagtacttaaga240cggaagaactacctggagacaggcaggggtctctgcttccccctggtgaaagcctgtgtg300tttggcaatgagcccaaggctcctgatgaggttctcctggctccgcggacagagacagcg360gaatccaccccgtcttggcaggtcctgaagctggtcttctgtgcctcgggtctccaggtg420tcctatctgacttggggcatactgcaggaaagagtgatgactggcagctacggggccaca480gccacatcaccaggagagcatttcacagactcccagtttctggtgctgatgaaccgtgtg540ctggcgctggttgtggcaggcctctactgtgtcctgcgcaagcagccccgtcatggtgca600cccatgtaccggtactcctttgccagtctgtcaaatgtgcttagcagctggtgccagtat660gaagcacttaagttcgtcagcttccctacccaggtgctggcgaaggcctccaaggtgatc720cctgtcatgatgatgggaaagctggtgtcccggcgcagctatgaacactgggaatacctg780actgccggcctcatctccattggagtgagcatgtttcttctatccagtggaccagagcct840agaagctctccagccaccacactctctggcttggtcctactggcaggctatattgctttc900gacagcttcacctcaaattggcaggatgccctgtttgcctataagatgtcatcggtgcag960atgatgtttggggtcaatttattctcctgtcttttcacagtaggctcactactggaacag1020ggggccctactggagggggcacgcttcatggggcggcacagtgagtttgcgctccatgct1080ctcctcctctccatctgctccgcctttgggcagctcttcatcttctacaccattggacaa1140tttggagctgctgtcttcactatcatcatgactctacgccaggctattgccatcctcctc1200tcctgcctcctctatggccatactgtcactgtggtggggggactgggagtagctgtggtc1260ttcactgccctcctactcagagtctatgcccggggccggaagcagcggggaaagaaggct1320gtgcccactgagcccccagtacagaaggtgtgagcagtgcagtaaagaccctcatcttct1380gaggcactggctcagtatcagcatacagcagaggattggagccctggaggcagcctcttt1440tgccttaaaagcccccacttcatggaaatgacagctgtgggtgtttggttagaggtgacc1500cagagctcctcccccaatctctgaaatcttgctggtggccaagcaaaccagcaccagggc1560tttgctcatagcacgcacccttgaggctaccaggcaccagctgggaagagaatttacagg1620tcctgcagttcccctaggggccagtgagaatggtgctgtgccagaagggacaaaggcccc1680cagcccagttggggccc1697<210>265<211>159<212>DNA<213>小鼠<220><400>265gttttcttctccaggctgaagacctgaacgtcaagttggaaggggagccttccatgcgga60aaccaaagcagcggccgcggccggagcccctcatcatccccaccaaggcgggcactttca120tcgcccctcctgtctactccaacatcaccccttaccaga159<210>266<211>292<212>DNA<213>小鼠<400>266gtggggtcccagacttgccaaccaaagggccattcctggtatatggttctggcttcagct60ctggtggcatggactatggtatggttggtggcaaggaggctgggaccgagtctcgcttca120aacagtggacctcaatgatggaagggctgccatctgtggccacacaagaagccaccatgc180acaaaaacggcgctatagtggcccctggtaagacccgaggaggttcaccatacaaccagt240ttgatataatcccaggtgacacactgggtggccatacgggtcctgctggtga292<210>267<211>339<212>DNA<213>小鼠<400>267ccactgaccttcccagaaggtgacagccggcggcggatgttgtcaaggagccgagatagt60ccagcagtgcctcggtacccagaagacgggctgtctccccccaaaagacggcgacattcg120atgagaagtcaccacagtgatctcacattttgcgagattatcctgatggagatggagtcc180catgatgcagcctggcctttcctagagcctgtgaaccctcgcttggtgagtggataccga240cgtgtcatcaagaaccctatggatttttccaccatgcgagaacgcctgctccgtggaggg300tacactagctcagaagagtttgcagctgatgctctgctg339<210>268<211>153<212>DNA<213>小鼠<400>268ctgaagttctctcatccttgtctggaagaccataatagttactgcattaatggagcatgt60gcattccaccatgagctgaagcaagccatttgcagatgctttactggttatacgggacaa120cgatgtgagcatttgaccctaacttcgtatgct153<210>269<211>153<212>DNA<213>人<400>269ttgaagttctcacacctttgcctggaagatcataacagttactgcatcaacggtgcttgt60gcattccaccatgagctagagaaagccatctgcaggtgttttactggttatactggagaa120aggtgtgagcacttgactttaacttcatatgct153<210>270<211>288<212>DNA<213>人<400>270gcggccgcgctgctcctgctgctgctggcgctgtacaccgcgcgtgtggacgggtccaaa60tgcaagtgctcccggaagggacccaagatccgctacagcgacgtgaagaagctggaaatg120aagccaaagtacccgcactgcgaggagaagatggttatcatcaccaccaagagcgtgtcc180aggtaccgaggtcaggagcactgcctgcaccccaagctgcagagcaccaagcgcttcatc240aagtggtacaacgcctggaacgagaagcgcagggtctacgaagaatag288<210>271<211>234<212>DNA<213>小鼠<400>271tccaagtgtaagtgttcccggaaggggcccaagatccgctacagcgacgtgaagaagctg60gaaatgaagccaaagtacccacactgcgaggagaagatggttatcgtcaccaccaagagc120atgtccaggtaccggggccaggagcactgcctgcaccctaagctgcagagcaccaaacgc180ttcatcaagtggtacaatgcctggaacgagaagcgcagggtctacgaagaatag234<210>272<211>234<212>DNA<213>人<400>272tccaaatgcaagtgctcccggaagggacccaagatccgctacagcgacgtgaagaagctg60gaaatgaagccaaagtacccgcactgcgaggagaagatggttatcatcaccaccaagagc120gtgtccaggtaccgaggtcaggagcactgcctgcaccccaagctgcagagcaccaagcgc180ttcatcaagtggtacaacgcctggaacgagaagcgcagggtctacgaagaatag234<210>273<211>645<212>DNA<213>小鼠<400>273atgctgtcgctccgctccttgcttccacacctgggactgttcctgtgcctggctctgcac60ttatccccctccctctctgccagtgataatgggtcctgcgtggtccttgataacatctac120acctccgacatcttggaaatcagcactatggctaacgtctctggtggggatgtaacctat180acagtgacggtccccgtgaacgattcagtcagtgccgtgatcctgaaagcagtgaaggag240gacgacagcccagtgggcacctggagtggaacatatgagaagtgcaacgacagcagtgtc300tactataacttgacatcccaaagccagtcggtcttccagacaaactggacagttcctact360tccgaggatgtgactaaagtcaacctgcaggtcctcatcgtcgtcaatcgcacagcctca420aagtcatccgtgaaaatggaacaagtacaaccctcagcctcaacccctattcctgagagt480tctgagaccagccagaccataaacacgactccaactgtgaacacagccaagactacagcc540aaggacacagccaacaccacagccgtgaccacagccaataccacagccaataccacagcc600gtgaccacagccaagaccacagccaaaagcctggccatccgcact645<210>274<211>63<212>DNA<213>小鼠<400>274gggtacagtgatggttaccaagtgtgtagtaggttcggaagcaaagtgcctcagtttctg60aac63<210>275<211>388<212>蛋白质<213>小鼠<400>275MetGlyLeuGluProSerTrpTyrLeuLeuLeuCysLeuAlaValSer151015GlyAlaAlaGlyThrAspProProThrAlaProThrThrAlaGluArg202530GlnArgGlnProThrAspIleIleLeuAspCysPheLeuValThrGlu354045AspArgHisArgGlyAlaPheAlaSerSerGlyAspArgGluArgAla505560LeuLeuValLeuLysGlnValProValLeuAspAspGlySerLeuGlu65707580GlyIleThrAspPheGlnGlySerThrGluThrLysGlnAspSerPro859095ValIlePheGluAlaSerValAspLeuValGlnIleProGlnAlaGlu100105110AlaLeuLeuHisAlaAspCysSerGlyLysAlaValThrCysGluIle115120125SerLysTyrPheLeuGlnAlaArgGlnGluAlaThrPheGluLysAla130135140HisTrpPheIleSerAsnMetGlnValSerArgGlyGlyProSerVal145150155160SerMetValMetLysThrLeuArgAspAlaGluValGlyAlaValArg165170175HisProThrLeuAsnLeuProLeuSerAlaGlnGlyThrValLysThr180185190GlnValGluPheGlnValThrSerGluThrGlnThrLeuAsnHisLeu195200205LeuGlySerSerValSerLeuHisCysSerPheSerMetAlaProAsp210215220LeuAspLeuThrGlyValGluTrpArgLeuGlnHisLysGlySerGly225230235240GlnLeuValTyrSerTrpLysThrGlyGlnGlyGlnAlaLysArgLys245250255GlyAlaThrLeuGluProGluGluLeuLeuArgAlaGlyAsnAlaSer260265270LeuThrLeuProAsnLeuThrLeuLysAspGluGlyThrTyrIleCys275280285GlnIleSerThrSerLeuTyrGlnAlaGlnGlnIleMetProLeuAsn290295300IleLeuAlaProProLysValGlnLeuHisLeuAlaAsnLysAspPro305310315320LeuProSerLeuValCysSerIleAlaGlyTyrTyrProLeuAspVal325330335GlyValThrTrpIlsArgGluGluLeuGlyGlyIleProAlaGlnVal340345350SerGlyAlaSerPheSerSerLeuArgGlnSerThrMetGlyThrTyr355360365SerIleSerSerThrValMetAlaAspProGlyProThrGlyAlaThr370375380TyrThrCysGln385<210>276<211>151<212>蛋白质<213>大鼠<400>276MetAlaGluProTrpAlaGlyGlnPheLeuGlnAlaLeuProAlaThr151015ValLeuGlyAlaLeuGlyThrLeuGlySerGluPheLeuArgGluTrp202530GluThrGlnAspMetArgValThrLeuPheLysLeuLeuLeuLeuTrp354045LeuValLeuSerLeuLeuGlyIleGlnLeuAlaTrpGlyPheTyrGly505560AsnThrValThrGlyLeuTyrHisArgProGlyLysTrpGlnGlnMet65707580LysLeuSerLysLeuThrGluAsnLysGlyArgGlnGlnGluLysGly859095LeuGlnArgTyrArgTrpValCysTrpLeuLeuCysCysThrLeuLeu100105110LeuSerArgProLeuArgGlnLeuGlnArgAlaTrpValGlyGlyLeu115120125GluTyrHisAspAlaProArgValSerLeuHisCysProGlnProCys130135140LeuGlnGlnArgGlnValLeu145150<210>277<211>163<212>蛋白质<213>大鼠<400>277MetProLeuValThrThrLeuPheTyrAlaCysPheTyrHisTyrThr151015GluSerGluGlyThrPheSerSerProValAsnLeuLysLysThrPhe202530LysIleProAspArgGlnTyrValLeuThrAlaLeuAlaAlaArgAla354045LysLeuArgAlaTrpAsnAspValAspAlaLeuPheThrThrLysAsn505560TrpLeuGlyTyrThrLysLysArgAlaProIleGlyPheHisArgVal65707580ValGluIleLeuHisLysAsnSerAlaProValGlnIleLeuGlnGlu859095TyrValAsnLeuValGluAspValAspThrLysLeuAsnLeuAlaThr100105110LysPheLysCysHisAspValValIleAspThrCysArgAspLeuLys115120125AspArgGlnGlnLeuLeuAlaTyrArgSerLysValAspLysGlySer130135140AlaGluGluGluLysIleAspValIleLeuSerSerSerGlnIleArg145150155160TrpLysAsn<210>278<211>330<212>蛋白质<213>大鼠<400>278MetAlaGlyTrpAlaGlyAlaGluLeuSerValLeuAsnProLeuArg151015AlaLeuTrpLeuLeuLeuAlaAlaAlaPheLeuLeuAlaLeuLeuLeu202530GlnLeuAlaProAlaArgLeuLeuProSerCysAlaLeuPheGlnAsp354045LeuIleArgTyrGlyLysThrLysGlnSerGlySerArgArgProAla505560ValCysArgAlaPheAspValProLysArgTyrPheSerHisPheTyr65707580ValValSerValLeuTrpAsnGlySerLeuLeuTrpPheLeuSerGln859095SerLeuPheLeuGlyAlaProPheProSerTrpLeuTrpAlaLeuLeu100105110ArgThrLeuGlyValThrGlnPheGlnAlaLeuGlyMetGluSerLys115120125AlaSerArgIleGlnAlaGlyGluLeuAlaLeuSerThrPheLeuVal130135140LeuValPheLeuTrpValHisSerLeuArgArgLeuPheGluCysPhe145150155160TyrValSerValPheSerAsnThrAlaIleHisValValGlnTyrCys165170175PheGlyLeuValTyrTyrValLeuValGlyLeuThrValLeuSerGln180185190ValProMetAsnAspLysAsnValTyrAlaLeuGlyLysAsnLeuLeu195200205LeuGlnAlaArgTrpPheHisIleLeuGlyMetMetMetPhePheTrp210215220SerSerAlaHisGlnTyrLysCysHisValIleLeuSerAsnLeuArg225230235240ArgAsnLysLysGlyValValIleHisCysGlnHisArgIleProPhe245250255GlyAspTrpPheGluTyrValSerSerAlaAsnTyrLeuAlaGluLeu260265270MetIleTyrIleSerMetAlaValThrPheGlyLeuHisAsnValThr275280285TrpTrpLeuValValThrTyrValPhePheSerGlnAlaLeuSerAla290295300PhePheAsnHisArgPheTyrLysSerThrPheValSerTyrProLys305310315320HisArgLysAlaPheLeuProPheLeuPhe325330<210>279<211>61<212>蛋白质<213>大鼠<400>279MetGluAsnIleTyrTyrThrAsnLeuIleThrIleLeuGlyAsnLys151015HisAlaAsnGlnMetGluLeuAsnLeuGlnAlaLeuIleLeuSerPro202530TrpPheAlaValCysAlaProProGlyPheAlaArgAspGlnAlaVal354045ArgGlyLeuAlaLeuAlaGlyArgArgIleThrValVal505560<210>280<211>105<212>蛋白质<213>大鼠<400>280MetLeuArgArgGlnLeuValTrpTrpHisLeuLeuAlaLeuLeuPhe151015LeuProPheCysLeuCysGlnAspGluTyrMetGluSerProGlnAla202530GlyGlyLeuProProAspCysSerLysCysCysHisGlyAspTyrGly354045PheArgGlyTyrGlnGlyProProGlyProProGlyProProGlyIle505560ProGlyAsnHisGlyAsnAsnGlyAsnAsnGlyAlaThrGlyHisGlu65707580GlyAlaLysGlyGluLysGlyAspLysGlyAspLeuGlyProArgGly859095GluArgGlyGlnHisGlyProLysGly100105<210>281<211>27<212>蛋白质<213>小鼠<400>281MetLeuLysAlaSerLeuHisIleLeuPheLeuGlyIleLeuAsnVal151015ProIleValAspThrSerThrLysThrGlyVal2025<210>282<211>169<212>蛋白质<213>小鼠<400>282MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>283<211>61<212>蛋白质<213>小鼠<400>283MetGluLysGlnMetAspAlaSerValSerValIlePheGlySerIle151015ValIleSerAlaPheLeuTyrLeuSerLeuAlaGlyProTrpAlaVal202530ThrValThrGlnMetArgThrIleIleIleThrMetAspGlnLeuArg354045AspAlaLeuIleLeuAspGlnLeuLysValAlaValSer505560<210>284<211>131<212>蛋白质<213>小鼠<400>284MetAlaProSerLeuTrpLysGlyLeuValGlyValGlyLeuPheAla151015LeuAlaHisAlaAlaPheSerAlaAlaGlnHisArgSerTyrMetArg202530LeuThrGluLysGluAspGluSerLeuProIleAspIleValLeuGln354045ThrLeuLeuAlaPheAlaValThrCysTyrGlyIleValHisIleAla505560GlyGluPheLysAspMetAspAlaThrSerGluLeuLysAsnLysThr65707580PheAspThrLeuArgAsnHisProSerPheTyrValPheAsnHisArg859095GlyArgValLeuPheArgProSerAspAlaThrAsnSerSerAsnLeu100105110AspAlaLeuSerSerAsnThrSerLeuLysLeuArgLysPheAspSer115120125LeuArgArg130<210>285<211>78<212>蛋白质<213>小鼠<400>285GlyThrArgLysProLeuProMetGluAlaHisSerArgArgGluLys151015AlaSerGlyLeuArgLeuAlaTrpHisTyrGluCysSerGlyValSer202530ValTrpTrpMetCysValLeuGlyTrpLeuSerPheLeuValPheLeu354045LeuPheSerLeuValCysSerPheProSerProIleAsnHisSerHis505560MetLeuProCysLeuPheLeuArgGlyGlyGlySerAsnVal657075<210>286<211>206<212>蛋白质<213>小鼠<400>286MetLeuProProAlaIleHisLeuSerLeuIleProLeuLeuCysIle151015LeuMetArgAsnCysLeuAlaPheLysAsnAspAlaThrGluIleLeu202530TyrSerHisValValLysProValProAlaHisProSerSerAsnSer354045ThrLeuAsnGlnAlaArgAsnGlyGlyArgHisPheSerSerThrGly505560LeuAspArgAsnSerArgValGlnValGlyCysArgGluLeuArgSer65707580ThrLysTyrIleSerAspGlyGlnCysThrSerIleSerProLeuLys859095GluLeuValCysAlaGlyGluCysLeuProLeuProValLeuProAsn100105110TrpIleGlyGlyGlyTyrGlyThrLysTyrTrpSerArgArgSerSer115120125GlnGluTrpArgCysValAsnAspLysThrArgThrGlnArgIleGln130135140LeuGlnCysGlnAspGlySerThrArgThrTyrLysIleThrValVal145150155160ThrAlaCysLysCysLysArgTyrThrArgGlnHisAsnGluSerSer165170175HisAsnPheGluSerValSerProAlaLysProAlaGlnHisHisArg180185190GluArgLysArgAlaSerLysSerSerLysHisSerLeuSer195200205<210>287<211>169<212>蛋白质<213>小鼠<400>287MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>288<211>114<212>蛋白质<213>小鼠<400>288MetSerValThrIleGlyArgLeuAlaLeuPheLeuIleGlyIleLeu151015LeuCysProValAlaProSerLeuThrArgSerTrpProGlyProAsp202530ThrCysSerLeuPheLeuGlnHisSerLeuSerLeuSerLeuArgLeu354045GlyGlnSerLeuGluGlyGlyLeuSerValCysPheHisValCysIle505560HisAlaCysGluCysValAlaCysCysArgValLeuTrpAspProLys65707580ProArgGlySerSerLeuCysArgTrpValLeuGlySerIleThrCys859095LeuPheMetTyrGluValGlyGlyTrpThrGlnGlyGlyLeuIleVal100105110SerLeu<210>289<211>46<212>蛋白质<213>小鼠<400>289MetHisTyrProCysLeuAlaCysLeuPheValAsnValHisTrpCys151015PheAlaTrpMetCysIleLeuValLysMetSerGluLeuLeuGluLeu202530GluLeuGluThrMetValSerCysLeuValAspValGlyAsn354045<210>290<211>199<212>蛋白质<213>小鼠<400>290MetValLeuProThrValLeuIleLeuLeuLeuSerTrpAlaAlaGly151015LeuGlyGlyGluThrArgProArgAlaAlaThrGluArgArgSerVal202530GlyProSerAlaArgArgGlyAlaGlyProArgValSerGlyLeuLeu354045GlyPheCysGlnLeuSerGlnLeuAlaSerAlaAspProGluArgArg505560SerProArgAlaIleValProArgAlaProArgProArgSerArgArg65707580ArgProCysLeuProGlyPheSerArgArgPheProArgGluArgArg859095SerProGlyGlnProProSerArgThrProGlnProProGlnProCys100105110ArgGlyProSerProGlyThrAlaGlnThrArgSerAsnLeuArgGly115120125TrpGlnArgGlyGlySerIleValLeuGlnAlaSerGluArgThrArg130135140AlaGlyCysArgThrProValCysValSerHisProSerAlaPhePro145150155160ProProArgAlaLeuPheGlyValPheValAlaSerAlaProGluVal165170175ValCysValCysValSerValValLeuSerValCysLeuLeuSerPro180185190ArgGlyLysThrLeuValAsp195<210>291<211>568<212>蛋白质<213>大鼠<400>291MetGluLeuLeuTyrTrpCysLeuLeuCysLeuLeuLeuProLeuThr151015SerArgThrGlnLysLeuProThrArgAspGluGluLeuPheGlnMet202530GlnIleArgAspLysAlaLeuPheHisAspSerSerValIleProAsp354045GlyAlaGluIleSerSerTyrLeuPheArgAspThrProArgArgTyr505560PhePheMetValGluGluAspAsnThrProLeuSerVa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nCysHisCysValAspSerTyrThrGly260265270ProThrCysArgGluValProThrGlnLeuSerSerIleArgProAla275280285ProGlnHisSerSerSerLysAlaMetLysHis290295<210>333<211>109<212>蛋白质<213>小鼠<400>333GlyThrArgValGlyThrProTyrTyrMetSerProGluArgIleHis151015GluAsnGlyTyrAsnPheLysSerAspIleTrpSerLeuGlyCysLeu202530LeuTyrGluMelAlaAlaLeuGlnSerProPheTyrGlyAspLysMet354045AsnLeuTyrSerLeuCysLysLysIleGluGlnCysAspTyrProPro505560LeuProSerAspHisTyrSerGluGluLeuArgGlnLeuValAsnIle65707580CysIleAsnProAspProGluLysArgProAspIleAlaTyrValTyr859095AspValAlaLysArgMetHisAlaCysThrAlaSerThr100105<210>334<211>787<212>蛋白质<213>小鼠<400>334LysValGluGlyGluGlyArgGlyArgTrpAlaLeuGlyLeuLeuArg151015ThrPheAspAlaGlyGluPheAlaGlyTrpGluLysValGlySerGly202530GlyPheGlyGlnValTyrLysValArgHisValHisTrpLysThrTrp354045LeuAlaIleLysCysSerProSerLeuHisValAspAspArgGluArg505560MetGluLeuLeuGluGluAlaLysLysMetGluMetAlaLysPheArg65707580TyrIleLeuProValTyrGlyIleCysGlnGluProValGlyLeuVal859095MetGluTyrMetGluThrGlySerLeuGluLysLeuLeuAlaSerGlu100105110ProLeuProTrpAspLeuArgPheArgIleValHisGluThrAlaVal115120125GlyMetAsnPheLeuHisCysMetSerProProLeuLeuHisLeuAsp130135140LeuLysProAlaAsnIleLeuLeuAspAlaHisTyrHisValLysIle145150155160SerAspPheGlyLeuAlaLysCysAsnGlyMetSerHisSerHisAsp165170175LeuSerMetAspGlyLeuPheGlyThrIleAlaTyrLeuProProGlu180185190ArgIleArgGluLysSerArgLeuPheAspThrLysHisAspValTyr195200205SerPheAlaIleValIleTrpGlyValLeuThrGlnLysLysProPhe210215220AlaAspGluLysAsnIleLeuHisIleMetMetLysValValLysGly225230235240HisArgProGluLeuProProIleCysArgProArgProArgAlaCys245250255AlaSerLeuIleGlyLeuMetGlnArgCysTrpHisAlaAspProGln260265270ValArgProThrPheGlnGluIleThrSerGluThrGluAspLeuCys275280285GluLysProAspGluGluValLysAspLeuAlaHisGluProGlyGlu290295300LysSerSerLeuGluSerLysSerGluAlaArgProGluSerSerArg305310315320LeuLysArgAlaSerAlaProProPheAspAsnAspCysSerLeuSer325330335GluLeuLeuSerGlnLeuAspSerGlyIleSerGlnThrLeuGluGly340345350ProGluGluLeuSerArgSerSerSerGluCysLysLeuProSerSer355360365SerSerGlyLysArgLeuSerGlyValSerSerValAspSerAlaPhe370375380SerSerArgGlySerLeuSerLeuSerPheGluArgGluAlaSerThr385390395400GlyAspLeuGlyProThrAspIleGlnLysLysLysLeuValAspAla405410415IleIleSerGlyAspThrSerArgLeuMetLysIleLeuGlnProGln420425430AspValAspLeuValLeuAspSerSerAlaSerLeuLeuHisLeuAla435440445ValGluAlaGlyGlnGluGluCysValLysTrpLeuLeuLeuAsnAsn450455460AlaAsnProAsnLeuThrAsnArgLysGlySerThrProLeuHisMet465470475480AlaValGluArgLysGlyArgGlyIleValGluLeuLeuLeuAlaArg485490495LysThrSerValAsnAlaLysAspGluAspGlnTrpThrAlaLeuHis500505510PheAlaAlaGlnAsnGlyAspGluAlaSerThrArgLeuLeuLeuGlu515520525LysAsnAlaSerValAsnGluValAspPheGluGlyArgThrProMet530535540HisValAlaCysGlnHisGlyGlnGluAsnIleValArgThrLeuLeu545550555560ArgArgGlyValAspValGlyLeuGlnGlyLysAspAlaTrpLeuPro565570575LeuHisTyrAlaAlaTrpGlnGlyHisLeuProIleValLysLeuLeu580585590AlaLysGlnProGlyValSerValAsnAlaGlnThrLeuAspGlyArg595600605ThrProLeuHisLeuAlaAlaGlnArgGlyHisTyrArgValAlaArg610615620IleLeuIleAspLeuCysSerAspValAsnIleCysSerLeuGlnAla625630635640GlnThrProLeuHisValAlaAlaGluThrGlyHisThrSerThrAla645650655ArgLeuLeuLeuHisArgGlyAlaGlyLysGluAlaLeuThrSerGlu660665670GlyTyrThrAlaLeuHisLeuAlaAlaGlnAsnGlyHisLeuAlaThr675680685ValLysLeuLeuIleGluGluLysAlaAspValMetAlaArgGlyPro690695700LeuAsnGlnThrAlaLeuHisLeuAlaAlaAlaArgGlyHisSerGlu705710715720ValValGluGluLeuValSerAlaAspLeuIleAspLeuSerAspGlu725730735GlnGlyLeuSerAlaLeuHisLeuAlaAlaGlnGlyArgHisSerGln740745750ThrValGluThrLeuLeuLysHisGlyAlaHisIleAsnLeuGlnSer755760765LeuLysPheGlnGlyGlyGlnSerSerAlaAlaThrLeuLeuArgArg770775780SerLysThr785<210>335<211>194<212>蛋白质<213>小鼠<400>335ProGlyCysLysSerCysThrValCysArgHisGlyLeuCysArgSer151015ValGluLysAspSerValValCysGluCysHisProGlyTrpThrGly202530ProLeuCysAspGlnGluAlaArgAspProCysLeuGlyHisSerCys354045ArgHisGlyThrCysMetAlaThrGlyAspSerTyrValCysLysCys505560AlaGluGlyTyrGlyGlyAlaLeuCysAspGlnLysAsnAspSerAla65707580SerAlaCysSerAlaPheLysCysHisHisGlyGlnCysHisIleSer859095AspArgGlyGluProTyrCysLeuCysGlnProGlyPheSerGlyHis100105110HisCysGluGlnGluAsnProCysMetGlyGluIleValArgGluAla115120125IleArgArgGlnLysAspTyrAlaSerCysAlaThrAlaSerLysVal130135140ProIleMetGluCysArgGlyGlyCysGlyThrThrCysCysGlnPro145150155160IleArgSerLysArgArgLysTyrValPheGlnCysThrAspGlySer165170175SerPheValGluGluValGluArgHisLeuGluCysGlyCysArgAla180185190CysSer<210>336<211>274<212>蛋白质<213>人<400>336TyrArgTyrCysGlnHisArgCysValAsnLeuProGlySerPheArg151015CysGlnCysGluProGlyPheGlnLeuGlyProAsnAsnArgSerCys202530ValAspValAsnGluCysAspMetGlyAlaProCysGluGlnArgCys354045PheAsnSerTyrGlyThrPheLeuCysArgCysHisGlnGlyTyrGlu505560LeuHisArgAspGlyPheSerCysSerAspIleAspGluCysSerTyr65707580SerSerTyrLeuCysGlnTyrArgCysValAsnGluProGlyArgPhe859095SerCysHisCysProGlnGlyTyrGlnLeuLeuAlaThrArgLeuCys100105110GlnAspIleAspGluCysGluSerGlyAlaHisGlnCysSerGluAla115120125GlnThrCysValAsnPheHisGlyGlyTyrArgCysValAspThrAsn130135140ArgCysValGluProTyrIleGlnValSerGluAsnArgCysLeuCys145150155160ProAlaSerAsnProLeuCysArgGluGlnProSerSerIleValHis165170175ArgTyrMetThrIleThrSerGluArgSerValProAlaAspValPhe180185190GlnIleGlnAlaThrSerValTyrProGlyAlaTyrAsnAlaPheGln195200205IleArgAlaGlyAsnSerGlnGlyAspPheTyrIleArgGlnIleAsn210215220AsnValSerAlaMetLeuValLeuAlaArgProValThrGlyProArg225230235240GluTyrValLeuAspLeuGluMetValThrMetAsnSerLeuMetSer245250255TyrArgAlaSerSerValLeuArgLeuThrValPheValGlyAlaTyr260265270ThrPhe<210>337<211>316<212>蛋白质<213>小鼠<400>337HisGluGluGluProCysAsnAsnGlySerGluIleLeuAlaTyrAsn151015IleAspLeuGlyAspSerCysIleThrValGlyAsnThrThrThrHis202530ValMetLysAsnLeuLeuProGluThrThrTyrArgIleArgIleGln354045AlaIleAsnGluIleGlyValGlyProPheSerGlnPheIleLysAla505560LysThrArgProLeuProProSerProProArgLeuGluCysAlaAla65707580SerGlyProGlnSerLeuLysLeuLysTrpGlyAspSerAsnSerLys859095ThrHisAlaAlaGlyAspMetValTyrThrLeuGlnLeuGluAspArg100105110AsnLysArgPheIleSerIleTyrArgGlyProSerHisThrTyrLys115120125ValGlnArgLeuThrGluPheThrCysTyrSerPheArgIleGlnAla130135140MetSerGluAlaGlyGluGlyProTyrSerGluThrTyrThrPheSer145150155160ThrThrLysSerValProProThrLeuLysAlaProArgValThrGln165170175LeuGluGlyAsnSerCysGluIlePheTrpGluThrValProProMet180185190ArgGlyAspProValSerTyrValLeuGlnValLeuValGlyArgAsp195200205SerGluTyrLysGlnValTyrLysGlyGluGluAlaThrPheGlnIle210215220SerGlyLeuGlnSerAsnThrAspTyrArgPheArgValCysAlaCys225230235240ArgArgCysValAspThrSerGlnGluLeuSerGlyAlaPheSerPro245250255SerAlaAlaPheMetLeuGlnGlnArgGluValMetLeuThrGlyAsp260265270LeuGlyGlyMetGluGluAlaLysMetLysGlyMetMetProThrAsp275280285GluGlnPheAlaAlaLeuIleValLeuGlyPheAlaThrLeuSerIle290295300LeuPheAlaPheIleLeuGlnTyrPheLeuMetLys305310315<210>338<211>237<212>蛋白质<213>小鼠<400>338MetLeuSerLeuArgSerLeuLeuProHisLeuGlyLeuPheLeuCys151015LeuAlaLeuHisLeuSerProSerLeuSerAlaSerAspAsnGlySer202530CysValValLeuAspAsnIleTyrThrSerAspIleLeuGluIleSer354045ThrMetAlaAsnValSerGlyGlyAspValThrTyrThrValThrVal505560ProValAsnAspSerValSerAlaValIleLeuLysAlaValLysGlu65707580AspAspSerProValGlyThrTrpSerGlyThrTyrGluLysCysAsn859095AspSerSerValTyrTyrAsnLeuThrSerGlnSerGlnSerValPhe100105110GlnThrAsnTrpThrValProThrSerGluAspValThrLysValAsn115120125LeuGlnValLeuIleValValAsnArgThrAlaSerLysSerSerVal130135140LysMetGluGlnValGlnProSerAlaSerThrProIleProGluSer145150155160SerGluThrSerGlnThrIleAsnThrThrProThrValAsnThrAla165170175LysThrThrAlaLysAspThrAlaAsnThrThrAlaValThrThrAla180185190AsnThrThrAlaAsnThrThrAlaValThrThrAlaLysThrThrAla195200205LysSerLeuAlaIleArgThrLeuGlySerProLeuAlaGlyAlaLeu210215220HisIleLeuLeuValPheLeuIleSerLysLeuLeuPhe225230235<210>339<211>469<212>蛋白质<213>小鼠<400>339MetLeuCysLeuCysLeuTyrValProIleAlaGlyAlaAlaGlnThr151015GluPheGlnTyrPheGluSerLysGlyLeuProAlaGluLeuLysSer202530IlePheLysLeuSerValPheIleProSerGlnGluPheSerThrTyr354045ArgGlnTrpLysGlnLysIleValGlnAlaGlyAspLysAspLeuAsp505560GlyGlnLeuAspPheGluGluPheValHisTyrLeuGlnAspHisGlu65707580LysLysLeuArgLeuValPheLysSerLeuAspLysLysAsnAspGly859095ArgIleAspAlaGlnGluIleMetGlnSerLeuArgAspLeuGlyVal100105110LysIleSerGluGlnGlnAlaGluLysIleLeuLysSerMetAspLys115120125AsnGlyThrMetThrIleAspTrpAsnGluTrpArgAspTyrHisLeu130135140LeuHisProValGluAsnIleProGluIleIleLeuTyrTrpLysHis145150155160SerThrIlePheAspValGlyGluAsnLeuThrValProAspGluPhe165170175ThrValGluGluArgGlnThrGlyMetTrpTrpArgHisLeuValAla180185190GlyGlyGlyAlaGlyAlaValSerArgThrCysThrAlaProLeuAsp195200205ArgLeuLysValLeuMetGlnValHisAlaSerArgSerAsnAsnMet210215220CysIleValGlyGlyPheThrGlnMetIleArgGluGlyGlyAlaLys225230235240SerLeuTrpArgGlyAsnGlyIleAsnValLeuLysIleAlaProGlu245250255SerAlaIleLysPheMetAlaTyrGluGlnMetLysArgLeuValGly260265270SerAspGlnGluThrLeuArgIleHisGluArgLeuValAlaGlySer275280285LeuAlaGlyAlaIleAlaGlnSerSerIleTyrProMetGluValLeu290295300LysThrArgMetAlaLeuArgLysThrGlyGlnTyrSerGlyMetLeu305310315320AspCysAlaArgArgIleLeuAlaLysGluGlyValAlaAlaPheTyr325330335LysGlyTyrIleProAsnMetLeuGlyIleIleProTyrAlaGlyIle340345350AspLeuAlaValTyrGluThrLeuLysAsnThrTrpLeuGlnArgTyr355360365AlaValAsnSerAlaAspProGlyValPheValLeuLeuAlaCysGly370375380ThrIleSerSerThrCysGlyGlnLeuAlaSerTyrProLeuAlaLeu385390395400ValArgThrArgMetGlnAlaGlnAlaSerIleGluGlyAlaProGlu405410415ValThrMetSerSerLeuPheLysGlnIleLeuArgThrGluGlyAla420425430PheGlyLeuTyrArgGlyLeuAlaProAsnPheMetLysValIlePro435440445AlaValSerIleSerTyrValValTyrGluAsnLeuLysIleThrLeu450455460GlyValGlnSerArg465<210>340<211>99<212>蛋白质<213>小鼠<400>340MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysSerMetSer505560ArgTyrArgGlyGlnGluHisCysLeuHisProLysLeuGlnSerThr65707580LysArgPheIleLysTrpTyrAsnAlaTrpAsnGluLysArgArgVal859095TyrGluGlu<210>341<211>431<212>蛋白质<213>小鼠<400>341MetAspAlaArgTrpTrpAlaValValValLeuAlaThrLeuProSer151015LeuGlyAlaGlyGlyGluSerProGluAlaProProGlnSerTrpThr202530GlnLeuTrpLeuPheArgPheLeuLeuAsnValAlaGlyTyrAlaSer354045PheMetValProGlyTyrLeuLeuValGlnTyrLeuArgArgLysAsn505560TyrLeuGluThrGlyArgGlyLeuCysPheProLeuValLysAlaCys65707580ValPheGlyAsnGluProLysAlaProAspGluValLeuLeuAlaPro859095ArgThrGluThrAlaGluSerThrProSerTrpGlnValLeuLysLeu100105110ValPheCysAlaSerGlyLeuGlnValSerTyrLeuThrTrpGlyIle115120125LeuGlnGluArgValMetThrGlySerTyrGlyAlaThrAlaThrSer130135140ProGlyGluHisPheThrAspSerGlnPheLeuValLeuMetAsnArg145150155160ValLeuAlaLeuValValAlaGlyLeuTyrCysValLeuArgLysGln165170175ProArgHisGlyAlaProMetTyrArgTyrSerPheAlaSerLeuSer180185190AsnValLeuSerSerTrpCysGlnTyrGluAlaLeuLysPheValSer195200205PheProThrGlnValLeuAlaLysAlaSerLysValIleProValMet210215220MetMetGlyLysLeuValSerArgArgSerTyrGluHisTrpGluTyr225230235240LeuThrAlaGlyLeuIleSerIleGlyValSerMetPheLeuLeuSer245250255SerGlyProGluProArgSerSerProAlaThrThrLeuSerGlyLeu260265270ValLeuLeuAlaGlyTyrIleAlaPheAspSerPheThrSerAsnTrp275280285GlnAspAlaLeuPheAlaTyrLysMetSerSerValGlnMetMetPhe290295300GlyValAsnLeuPheSerCysLeuPheThrValGlySerLeuLeuGlu305310315320GlnGlyAlaLeuLeuGluGlyAlaArgPheMetGlyArgHisSerGlu325330335PheAlaLeuHisAlaLeuLeuLeuSerIleCysSerAlaPheGlyGln340345350LeuPheIlePheTyrThrIleGlyGlnPheGlyAlaAlaValPheThr355360365IleIleMetThrLeuArgGlnAlaIleAlaIleLeuLeuSerCysLeu370375380LeuTyrGlyHisThrValThrValValGlyGlyLeuGlyValAlaVal385390395400ValPheThrAlaLeuLeuLeuArgValTyrAlaArgGlyArgLysGln405410415ArgGlyLysLysAlaValProThrGluProProValGlnLysVal420425430<210>342<211>51<212>蛋白质<213>小鼠<400>342LeuLysPheSerHisProCysLeuGluAspHisAsnSerTyrCysIle151015AsnGlyAlaCysAlaPheHisHisGluLeuLysGlnAlaIleCysArg202530CysPheThrGlyTyrThrGlyGlnArgCysGluHisLeuThrLeuThr354045SerTyrAla50<210>343<211>51<212>蛋白质<213>人<400>343LeuLysPheSerHisLeuCysLeuGluAspHisAsnSerTyrCysIle151015AsnGlyAlaCysAlaPheHisHisGluLeuGluLysAlaIleCysArg202530CysPheThrGlyTyrThrGlyGluArgCysGluHisLeuThrLeuThr354045SerTyrAla50<210>344<211>95<212>蛋白质<213>人<400>344AlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuTyrThrAlaArgVal151015AspGlySerLysCysLysCysSerArgLysGlyProLysIleArgTyr202530SerAspValLysLysLeuGluMetLysProLysTyrProHisCysGlu354045GluLysMetValIleIleThrThrLysSerValSerArgTyrArgGly505560GlnGluHisCysLeuHisProLysLeuGlnSerThrLysArgPheIle65707580LysTrpTyrAsnAlaTrpAsnGluLysArgArgValTyrGluGlu859095<210>345<211>77<212>蛋白质<213>小鼠<400>345SerLysCysLysCysSerArgLysGlyProLysIleArgTyrSerAsp151015ValLysLysLeuGluMetLysProLysTyrProHisCysGluGluLys202530MetValIleValThrThrLysSerMetSerArgTyrArgGlyGlnGlu354045HisCysLeuHisProLysLeuGlnSerThrLysArgPheIleLysTrp505560TyrAsnAlaTrpAsnGluLysArgArgValTyrGluGlu657075<210>346<211>77<212>蛋白质<213>人<400>346SerLysCysLysCysSerArgLysGlyProLysIleArgTyrSerAsp151015ValLysLysLeuGluMetLysProLysTyrProHisCysGluGluLys202530MetValIleIleThrThrLysSerValSerArgTyrArgGlyGlnGlu354045HisCysLeuHisProLysLeuGlnSerThrLysArgPheIleLysTrp505560TyrAsnAlaTrpAsnGluLysArgArgValTyrGluGlu657075<210>347<211>215<212>蛋白质<213>小鼠<400>347MetLeuSerLeuArgSerLeuLeuProHisLeuGlyLeuPheLeuCys151015LeuAlaLeuHisLeuSerProSerLeuSerAlaSerAspAsnGlySer202530CysValValLeuAspAsnIleTyrThrSerAspIleLeuGluIleSer354045ThrMetAlaAsnValSerGlyGlyAspValThrTyrThrValThrVal505560ProValAsnAspSerValSerAlaValIleLeuLysAlaValLysGlu65707580AspAspSerProValGlyThrTrpSerGlyThrTyrGluLysCysAsn859095AspSerSerValTyrTyrAsnLeuThrSerGlnSerGlnSerValPhe100105110GlnThrAsnTrpThrValProThrSerGluAspValThrLysValAsn115120125LeuGlnValLeuIleValValAsnArgThrAlaSerLysSerSerVal130135140LysMetGluGlnValGlnProSerAlaSerThrProIleProGluSer145150155160SerGluThrSerGlnThrIleAsnThrThrProThrValAsnThrAla165170175LysThrThrAlaLysAspThrAlaAsnThrThrAlaValThrThrAla180185190AsnThrThrAlaAsnThrThrAlaValThrThrAlaLysThrThrAla195200205LysSerLeuAlaIleArgThr210215<210>348<211>21<212>蛋白质<213>小鼠<400>348GlyTyrSerAspGlyTyrGlnValCysSerArgPheGlySerLysVal151015ProGlnPheLeuAsn<210>349<211>417<212>DNA<213>小鼠<400>349gctagccgtgcacccagctctccggagcgcgtgcaggcgagccgagcgccccgtccgcgg60ttctcgggcaggcgctgcgggctccccggctccccgccgtcccgggcacccgggcgggcc120atgcgcccgggctagagcgtagccgccggcatgccgctcccgctgctgctcgccgcgctc180tgcctcgccgcctccccggcgcccgcgcgcgcctgccagctgccgtcggagtggagaccc240ttgagcgaaggctgccgcgccgagctagccgagaccatcgtgtatgccaaggtgctggcg300ctgcaccccgaggtgcctggcctctacaactacctgccgtggcagtaccaagctggagag360ggagggctcttctactccgccgaggtggagatgcttgtgtgaccaaggcgtggggca417<210>350<211>1837<212>DNA<213>小鼠<400>350cccccacctgcccagccaagccgagtgccgccggctttgttcgctttgtcctcgcgcacc60taagcggccggcctggaagaacgccatcccggagagcgcacgcggcgtcgcaccaggtct120aacaacatgcctccacttctgcttctaccagccatctacatgctcctgttcttcagagtg180tccccgaccatctctcttcaggaagtgcatgtgaaccgggagaccatggggaagatcgct240gtggccagcaaattaatgtggtgctcagccgcggtcgacatcctgtttctgttagatggc300tctcacagcatcgggaaggggagcttcgagaggtccaagcgcttcgccatcgctgcctgt360gatgccctggacatcagccctggcagggtcagagtcggagccttgcagtttggttccact420cctcatctggaattccccttggactccttctcaactcgacaggaagtgaaggaaagcatc480aaggggatagttttcaaaggtgggcgcaccgagacgggcctagccctgaaacgcctgagc540agagggttccccggaggcagaaatggctctgtgccccagattcttatcatcgtcacggat600ggcaagtcccaggggcccgtggctctcccggctaagcagctgagagaaaggggcatcgtc660gtgtttgccgtaggagtccgttttcccaggtgggacgagctgctcacgctggccagtgag720ccgaaggaccggcatgtgctgttggctgagcaagtggaggatgccaccaatggcctcctc780agcaccctcagcagctccgcactctgcaccactgctgatccagactgcagggtggaacct840catccctgtgagcggaggacgctggagaccgtcagggagctcgctggcaatgccttgtgc900tggagaggatcaaggcaagcagacactgtgctggctctgccctgtcccttctacagctgg960aagagagtgttccagacacaccctgccaactgctacagaaccatctgtccaggcccctgt1020gactcccagccctgccaaaatggaggcacgtgcattccagaaggtgtggataggtaccac1080tgtctctgcccactggcattcggaggggaagtcaactgtgccccgaagctgagcctggaa1140tgcagaatcgatgtcctcttcctgctggacagttctgcaggcaccacattggggggcttc1200cggagggccaaggcctttgtcaagcgctttgtgcaggccgtgctgagggaggactcccga1260gcccgcgttgggatagccagttatggcaggaatctaatggtggcggtgccctgtcgggga1320gtaccagcattgtgccggacctgatcaggagccttgacagcattcccttcagcggtggcc1380cgaccctaaccgggagtgccttgctccaggtggcagagcacggctttgggagtgccagca1440ggactggtcaggacaggccacgcagagtagtagttctgctcactgaatcacgctcccagg1500atgaggtgtctgggccagcagctcacgcaagggctcgggagctactcctcctgggcgtgg1560gcagtgagatcctgcaggcggagctggtgaagatcaccggtagcccgaagcatgtgatgg1620tccacacagaccctcaggacctgtcagccaaatccagagctgcagaggaggctatgcagc1680cagccacggccaggctgccaggcacagtcactggacctggtcttcctgtggatgcctctg1740ctctgtgggacgtgagaactttgcccaaatgcagagcttcatcaggaaatgcaccctccg1800gtttgatgtgaatcctgatgtgacacaagttggcctg1837<210>351<211>941<212>DNA<213>小鼠<400>351taagccctcaggccctcctaatgctatccccctttgttcctgcagcgtggacccagtcag60cagccaggccatggagctctctgatgtcaccctcattgagggtgtgggtaacgaggtgat120ggtggtagcaggcgtggtggcgctgactctagccctggtcctagcctggctctccaccta180tgtagcagacagtggtaacaaccagctgctgggcaccattgtgtcagcaggtgacacgtc240tgttctccacctgggccatgtggaccagctggtaaaccaaggcactccagagccaaccga300acacccccatccatcagggggcaatgatgacaaggctgaagagaccagtgacagtggggg360agacgccactggagaacctggagctaggggagagatggagcccagcctggagcatctcct420ggacatccaaggcctgcctaaaaggcaagcaggcctggggagcagtcgcccagaagcccc480gctggggttagatgatggctcctgcctctctcccagccccagcctcatcaatgttcgcct540caagttcctcaatgacacggaggagctagctgtggccaggccagaggacactgtgggtac600cctaaaaaggtgagtaggccggagagaggccagttgctcgtgacttgttcctcagatgat660ggtttcctgaagaagctgtgcatatatgtgagcacaggagggattttaaggggaaatgga720gacttccatagacagaccttcagtgtctttcatgtccaggccttgatctctctagcctta780ttctttatccagtctttcctttcatccttgtagcaaatacttccctggacaagagaacca840aatgaagttgatctaccagggtcggctgctgcaggacccagcacgcacactgagttccct900gaacattaccaacaactgcgtgatccactgccaccgctcac941<210>352<211>571<212>DNA<213>小鼠<400>352gctgaotgtacctataattcaccatgaattacgtctgtgagttacctccgtgagctctca60ttgtgatttgagtatgtgtgcatgtggttggggctcagctgctgtgcgcctgacatccac120atttggatgtcttttggttccgtgaacaagtagaaattgcatgtgtctaccggtgacagt180gtggtgtcactgggccctgtgggtggctcacttacctctgattccgtctgtgggaaagtc240ccagtgtacccaaatgtggcattgttgcatgccttgggtgtgtgtgggagattgtctctg300tctctcagaccctttgtggctttgtctgttgaaagagacagagaccccttgtggttttct360cagctgagaaccctccctcctgggatgttgggtgtaaacttaactgctttgcaaagcctg420cccctcctcatgctgacccttcaatatctggcagtgcattgttcccaagccccccttgtc480tatgggaatgtcagggctctctcaccttgacagctgataattccattcctcgactcttga540gaactggcccttgctttgttttctctgcctg571<210>353<211>467<212>DNA<213>大鼠<400>353cggagaatgagcgggtggccgtggctgcagctgctgcggcggcactgacaggacacgagc60tctatgcctttccggctgcttatcccgctcggcctcgtgtgcgtgctgctgcccctgcac120catggtgcgccaggccccgaaggcaccgcgcccgaccccgcccactacagggagcgagtc180aaggccatgttctaccacgcctacgacagttacctggaaaatgcctttccctacgatgag240ctgagacctctcacctgtgacgggcacgacacctggggcagtttttctctgacactgatt300gatgccctggacaccttgctgattttggggaatacctctgaattccaaagagtggtggag360gttctccaggacaaacgtggactttgatatcgacgtcaatgcctctgtgttcgaaaccaa420catccgagtggtaggaggactcctttctgctcatctcttgtcaaaga467<210>354<211>528<212>DNA<213>大鼠<400>354gtgactcctgctgtaggaccctccaggaagcactggcctctcctacagagtcctccacct60agcaccggccttaatgctaaagccaaatgtggtttctgccctgcagcgtgcccctggtaa120tctcgagttgccactcccaagccagcccccactggccatatggcatcatatctgggggtc180aggagggcctgtgcaggctttggacagccacttgccacagcagaggagagagtgaggttt240ccaggagcagcaggaaggaagaccccagaattccccagggctctttgagtggtaatgttg300acttctggagagtctgcccaccttgtgctcacacaagcatggacaggacactgggacttt360tatcctgttgttaagctgtttccacagaagcccgttcaggtagttacttcacccacattg420gccctatagccagaggagtgccctggctaactgcagtgtgagcttgtaagcaacagaagt480gcccaggagctgaccccaaaggccaggaaggctcgagcttgccacttt528<210>355<211>473<212>DNA<213>小鼠<400>355ggcagcaggaccgcggtcactgagcctctgcaggtgtcaacaaggctcaaggagcaggat60ggatctcgatgtggttaacatgtttgtgattgcgggtgggaccctggccattccaatcct120ggcatttgttgcgtctttcctcctgtggccttcagcactgataagaatctattattggta180ctggcggaggacactgggcatgcaagttcgctacgcacaccatgaggactatcagttctg240ttactccttccggggcaggccaggacacaagccatccatccttatgctccatggattctc300cgcacacaaggacatgtggctcagcgtggtcaagttccttccgaagaacctgcacttggt360ctgtgtggacatgcctgggcatgaaggcaccacccgctcctccctggatgacctgtccat420agtggggcaagttaaaaggatacatcagtttgtagaatgccttaagctgaaca473<210>356<211>431<212>DNA<213>大鼠<400>356cttaactagcgcccccatccaccatgtttcctgacggattctagccttgtttgttttttt60caacctaaaaccaaatggaaatggccggagagctccagggcacctaggttccctggcttc120ggcttcggctgggctaacgcgcgagtgtggtgggactatcctaggaggtgttcctggaga180gagaggcgatggcgtcaagtagtaactggctgtccggagtgaatgtcgttcttgtgatgg240cgtacgggagcctggtattcgtattgctgtttatttttgtgaagagacaaatcatgcgct300ttgcaatgaaatctagaaggggacctcatgtccctgtgggacacaatgccccgaaggact360taaaagaggaaattgatattcggctatccagagttcaggacatcaagtatgaaccgcagc420tccttgcagat431<210>357<211>1206<212>DNA<213>小鼠<400>357ccaacactcgccatgcgttctggggcactgtggccgctgctttggggagccctggtctgg60acagtgggatccgtgggcgccgtgatgggctccgaggattctgtgcccggtggcgtgtgc120tggctccagcagggcagagaggccacctgcagtctggtgctgaagactcgtgtcagccgg180gaggagtgctgtgcttccggcaacatcaacaccgcctggtccaacttcacccacccaggc240aataaaatcagcctgctagggttcctgggcctcgtccactgcctcccctgcaaagattcc300tgcgacggagtggagtgcggccccggcaaggcgtgccgcatgctgggggggcgtccaaca360ctgcgaagttgcgtgcccaactgcgaggggyttcccgcgggcttccaggtctgcggctct420gatggcgccacctaccgggacgaatgcgaactgcgcaccgcgcgctgtcgcggacaccca480gacttgcgcgtcatgtaccgcggccgctgtcaaaagtcttgcgctcaggtagtgtgcccg540cgtccccagtcgtgccttgtggatcagaccggcagcgcacactgcgtggtgtgtcgcgct600gcgccctgcccagtaccttccaaccccggccaagaactctgtggcaacaacaacgttacc660tacatctcgtcgtgtcacctgcgccaggccacttgcttcctgggccgctccattggggtt720cggcacccaggcatctgcacaggtggccccaaagtaccagcagaggaggaagagaacttc780gtgtgagctgcagccactgggcctggcatttgacgccatcccgattttatttattgttat840agaaaatattctaatttatgtcacatggacatttcccaaacctggcctggaaccacttgg900ggatccccctgggatcctgagcacgtatcacaaggactgaagggagatttttataatagt960tggtatgtgccatcacccargtactgggatcaaagttagaacccaagacccctgctgccc1020agggatggcagctgcatggagatccccctgctatgatctccccacctgctttctaggctg1080gagctgtcgcagggcacagccgatgagttggtgtttgcatatggctggcctcagaccaga1140gcgggcaacatcaggtcagagaaacactgggctcattcctgtttggtccactcagggtga1200aacctg1206<210>358<211>1052<212>DNA<213>大鼠<400>358ccagaaagaacgatttagatgacagtttttagaaaggtgaccaccatgatctcctggatg60ctcttggcctgtgcccttccgtgtgctgctgacccaatgcttggtgcctttgctcgcagg120gacttccagaagggtggtcctcaactggtgtgcagtctgcctggtccccaaggccacctg180gccctccaggagcaccaggatcctcaggaatggtgggaagaatgggttttcctggtaagg240atggccaagacggccaggacggagaccgaggggacagtggagaagaaggtccacctggca300ggacaggcaaccgaggaaaacaaggaccaaagggcaaagctggggccattgggagagcgg360gtcctcgaggacccaagggggtcagtggtacccccgggaaacatggtataccgggcaaga420agggacctaagggcaagaaaggggaacctgggctcccaggcccctgtagctgcggcagta480gccgagccaagtcggccttttcggtggcggtaaccaagagttacccacgtgagcgactgc540ccatcaagtttgacaagattctgatgaatgagggaggccactacaatgcatccagtggca600agttcgtctgcagcgtgccagggatctattactttacctatgacattacgctggccaaca660aacacctggccatcggcctagtgcacaatggccagtaccgcattcggacttttgacgcca720acaccggcaaccacgacgtggcctcgggctccaccatcctagctctcaaggagggtgatg780aagtctggttacagattttctactcggagcagaatggactcttctacgacccttattgga840ccgacagcctgttcaccggcttcctcatctacgctgatcaaggagaccccaatgaggtat900agacaagctggggttgagcgtccaggcagggactaagattccgcaagggtgctgatagaa960gaggatctctgaactgaggctggggactggcagttcttgggagcttttattcccaggcaa1020gcctcctctggtgctgctttaaaaaaaaaaaa1052<210>359<211>1134<212>DNA<213>大鼠<400>359aattcggcacgaggcggtcagaacccgggcttctcgtttgtcctgaacggcactaccagg60gcggtggaagcagagatggcggagggcggtgggaggagaggcgtctagtcttgctggctc120agcaagcccgataagcatgaagctgctgtgtttggtggctgtggtggggtgcttgctggt180acccccggctcaagccaacaagagctctgaagatatccggtgcaaatgcatctgtccccc240ttacagaaacatcagcgggcacatttacaaccagaatgtgtctcagaaggactgcaactg300cctgcatgtggtggagcccatgccggtgcctggccatgatgtggaagcctactgcctgct360ctgtgagtgtaggtatgaggagcgcagcaccacaaccatcaaggtcattatcgtcatcta420cctgtctgtggtaggggccctcttactctacatggccttcctgatgctggtggaccctct480catccgaaagccggatgcctatactgagcagctgcacaatgaagaagagaatgaggatgc540ccgctccatggctgccgccgccgcatccattggaggaccccgagcaaacaccgtcctgga600gcgggtggaaggcgctcagcagcgatggaagctacaggtgcaggagcagcggaagacggt660cttcgatcgacacaagatgctcagttagatgattgccatggcagtgtcagggacccagac720ctcggctaccagcttctggggcagtcttccctgggtcttcccttcaaatgcccgtggcat780ttgtccttctccctctctctagaaatgtactcgactgttataactagggagtgggattgg840gtctttggtctctagtgtctctgtaggtctctggggtagaagggagggaaaggaaggcag900aagagaacagagatggttgagacggccacacgattggtgaaattcctccctcctgtcctc960gccgttcctcacagctccacatcttaaggatgtttatagctctttgggagacggagctgt1020gccgtcaatagctcggtgggtgcgacgaaagtgtgacccagccctcagcctgtgctctac1080gatgccgtggcccccattcccacttttncagtgccaatactttagcttggcctg1134<210>360<211>876<212>DNA<213>小鼠<400>360tgccagctgccccttcgagtgcttatcatcagcaacaacaagttaggagccctgcctcca60gacatcagcaccttgggaagcctgcggcagcttgatgtgagcagcaatgagctgcagtcc120ctgcccgtggagctgtgtagcctccgttccctgcgggatctcaatgttcgaaggaaccag180ctcagtaccctgcctgatgagctgggagaccttcctctggtccgcctggatttctcctgt240aaccgcatctcccgaatccccgtctccttctgccgcctcaggcacctgcaggtcgttctg300ctggatagcaaccccctacagagtccacctgcccagatatgcctgaaggggaaacttcac360atcttcaagtacctaacaatggaagctggccggaggggagccgccctcggggacctggtc420ccttcccgccccccaagttttagtccttgccctgccgaagatttatttccgggacgtcgt480tatgatggtggcctggactcaggcttccacagcgttgacagtggcagcaagaggtggtca540ggaaatgagtccacagatgatttttcagagctgtctttccggatctcggagctggctcgt600gatccccgggggcctagacaacctagggaagatggcgctggcgatggagacctggagcag660attgactttattgacagccacgttcctggggaagatgaagatcgaagtgcagctgaggag720cagctgccttctgaattaagccttgtagcaggggatgtggagaagccatctagcagcagg780cgagaggagcctgcaggggaggagaggcggcgcccagacactttgcagttgtggcaggaa840cgggagcggaagcaacagcaacagagtgggggatgg876<210>361<211>495<212>DNA<213>小鼠<400>361gtcgcgccagctgagagcccctaggtttgaccctcgtgcgggattccacgcggagggcaa60ggacagaggcccctctgttccccagggcctgctgaaggcagcgagaagcagcggccaact120caacttggcgggaaggaacctcggggaagtccctcagtgtgtttggagaataaatgtgga180cattcctgaagaggctaatcagaatctttcattcagttctactgaacgatggtgggatca240gacagatctgaccaaactcatcatctccagcaataaacttcagtctctctctgatgacct300ccgactcttgcctgcccttactgttcttgatatacatgataatcagctgacatctcttcc360ttcagctataagagagctagacaatcttcagaaacttaatgtcagccataacaaactgaa420aatactgcctgaagaaattacaagcttaaaaaacctgaggacgctgcacctccagcacaa480tgagctgacttgcat495<210>362<211>349<212>DNA<213>小鼠<400>362tctctgtctatcttgcctgctgtgagggtatcacccaggcccacttatccatctacagcg60agtagtatggcggccttccttgtaacaggctttttcttttctctcttcgtggtgcttggg120atggaacccagggctttgtttaggcctgacaaggctctgcccctgagctgtgccaagccc180acctccctctgtgtacaaagctcctttcttgggtgaccaacatcttcctgtctttgagca240accaaggccagatgcgagccacccagaagttaattaaaccaggttcatcgggagtttgct300gaaatgttaagcatactctgttctagagagggagtgaagaaaggggcca349<210>363<211>380<212>DNA<213>小鼠<400>363gagtatgaagccagagtcttagagaagtcactgagaaaagaatccagaaacaaagagacc60gacaaggtgaagctgacctggagggaccgattcccagcctatttcaccaatcttgtctcc120atcatcttcatgatcgcagtgacatttgcaatcgtcctcggagttatcatctatagaatc180tccacagctgcagccttggccatgaactcctccccgtctgtgcggtccaacatccgggtt240acagtcacggccaccgctgttatcatcaacctcgtggtcatcattctgctggatgaagtt300tacggctgcattgccaggtggctcaccaagattggtgagtgccatgtgcaggacagcata360ggcagcatgggcctagggca380<210>364<211>351<212>DNA<213>小鼠<400>364gcggcagagaacgagatgccggtggctgtgggtccctacgggcagtcccagcccagctgc60ttcgaccgcgtgaagatgggctttgtcatgggttgcgccgtgggtatggcggccggggcc120ctgttcggcaccttctcctgtctcaggatcggaatgcggggtcgggagctgatgggcggc180attgggaaaaccatgatgcagagtggcggtacctttggcactttcatggccatcggaatg240ggcatacgatgctaattagggcacggatgccctgctacacccaaacttcctcatccattt300cgaaccttgtacaataaagtttttttcttcttgttaaaaaaaaaaaaaaaa351<210>365<211>854<212>DNA<213>大鼠<400>365gcggtggctcctctgtgtcccacgtcctgaggggctcaggacaagaaaggagcccacccc60cagccagtatgcagccgccctggggcctggcgctccctctgctgctcccctgggtggcag120gtggagtagggaccagcccacgggattattggttgccagcactggcacaccagcctgggg180tctgtcactacggaactaagacggcctgctgctatggctggaaaaggaacagcaaaggag240tatgtgaagctgtgtgtgagcccagatgcaagtttggtgagtgtgtgggaccgaataaat300gtagatgctttccaggatacaccgggaagacctgcagtcaagacgtgaatgagtgtgcat360tcaaaccccggccatgccagcacagatgtgtgaatacacacggtagctacaaatgctttt420gcctcagcggccacatgcttctaccagacgccacatgttcaaactccaggacatgtgcca480gaataaactgccagtacagttgtgaagacacagcagaagggccacgatgtgtgtgtccat540cctctggcctccgcctgggtccaaatggaagagtgtgcctagatatcgatgaatgtgctt600ctagcaaagcagtctgtccttccaatagaagatgtgtgaacacatttggaagctactact660gcaaatgtcacattggttttgaactgaaatatatcagtcgccgatatgattgtgtagata720taaatgagtgcactctgaatacccgtacgtgcagcccccatgccaattgcctcaataccc780aaggatccttcaagtgcaaatgcaagcagggatacagggggaatggactgcagtgttctg840tgattcctgaacat854<210>366<211>257<212>DNA<213>大鼠<400>366ggcgcacccatgtacttcagcgagggccgagagagaggcaaggtgtatgtctacaacctg60agacagaaccggtttgtttttaatggcactctgaaggattcccacagctaccagaacgcc120cggttcgggtcatgcattgcctccgttcaagacctcaaccaagattcctacaatgacgtg180gtggtgggggcccctcaggaggacagccacagaggggccatctacatcttccatggcttc240caaaccaacatcctgaa257<210>367<211>475<212>DNA<213>大鼠<400>367cttccaaaccaacatcctgaagaagcccgtgcagagaatatcagcctcagagctggctcc60cggcttgcagcattttggctgcagcatccacggacaactggacctcaatgaggacgggct120tgtggacctagcagtgggcgccctgggcaacgctgtggttttgtgggcgcgtcccgtagt180tcagatcaacgccagcctccactttgagccttccaagatcaacatcttccacaaggactg240caagcgcaatggcagggatgccacctgcctggctgccttcctctgcttcggacctatctt300cctggcaccccacttccacacagcaaccgtcggcatcaggtacaatgcaaccatggatga360gagacggtatatgccacgggcacatctggatgagggtgcagaccagttcaccaacagggc420tgtcctactctcttctggtcaggaacactgtcaaaggatcaacttccacgtcctg475<210>368<211>392<212>DNA<213>小鼠<400>368gccgcggagcaggaagcgagcagccggcggaggcgcggcggcgccgggccggccttgttt60tcctcaggctcgctccgctctgagccgcagcctcgcttgcctcaggctcgctctcggccg120cggccttctttccttcaggctcggtcgcggccttgcttgtcccaggcttgctccccggcc180gcctccgtcctctcttcaagctcgctctgcggccgttcccacctccttccaggctcgctc240cccgccaccgcattcctcctcctcctcccaggctcgctcccgggccgccgcccctcagcc300gcccaggctgcgccggtgctcgcgtggggccttgttgcgtttcagctcggggtcgccgca360ggggcggggcgctgagcggtctgccgcggcct392<210>369<211>824<212>DNA<213>大鼠<400>369cgggcactgtgactgccaagccggctatgggggcgaggcctgtggccagtgtggccttgg60ctactttgaggcagagcgcaacagcagccatctggtatgttcggcgtgctttggtccctg120tgcccgctgcacaggacccgaggaatcccactgtctgcagtgcaggaaaggctgggccct180gcatcacctcaagtgtgtagacatcgatgagtgtggcacagagcaagctacctgtggagc240cgaccagttctgtgtgaacacggaagggtcctatgagtgccgagattgtgcaaaggcctg300cctgggctgtatgggagcagggccagggccctgcaaaaaatgcagccgtggctaccagca360ggtgggctccaagtgcctagatgtggatgagtgtgagacagtggtgtgtccaggagagaa420cgagcagtgtgaaaacacggaaggtagctaccgctgtgtctgtgctgaaggcttcagaca480ggaggacggcatctgtgtgaaggagcagatcccagagtcggcgggcttcttcgcggagat540gacagaggacgaaatggtggtcctgcagcagatgttctttggtgtgatcatctgtgcact600ggccacacttgctgctaagggggacttggtgttcaccgccatcttcattggagctgtggc660agctatgactgggtactggttgtcagagcgcagtgaccgtgtgctggagggcttcatcaa720gggtagataatccctgccaccacttacaggatttcctcccacccaggctgcccctagagg780ttatttctctctcccgctggacacctgggacagcattgtttctc824<210>370<211>1663<212>DNA<213>小鼠<400>370gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaagagcatgtccaggtaccggggccaggagcactgcct420gcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgagaa480gcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagttg540agagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagcat600aagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacattttata660gctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcatta720caagtggctttttgctgggcggttggcggggggcggggggacctcaagcctttccttttt780aaaataaggggttttgtatttgtccatatgtcaccacacatctgagctttataagcgcct840gggaggaacagtgagcatggttgagaccgttcacagcactactgctccgctccaggctta900caaagcttccgctcagagagcctggcggctctgtgcagctgccacaggctctcctgggct960tatgactggtcagagtttcagtgtgactccactgtggcccctgttgcagggcaattggga1020gcaggtccttctacatctgtgcctagaggaactcagtctacttaccagaaggagcttcat1080ccccaccccacccccacccgcaccccagctcattcccctgtcacgaccaggcaagtgatc1140cttaaaggagctgggtctttttcttgcaaactgagggtttctgaaaggtcggctgctttg1200gtagaagatgcttctgaggcatccaaagtccccagcagtgtgagaaaatgattctcgatg1260ttcgggaggacaagggaagatgcaggattagatgcaggacacacagccagagctacacat1320cctcttggcaatgggagctccccccccccaaagctttgtttctttccctcaccccaacag1380aaagtgcactccccctcagtgaatacgcaaacagcactgttctctgagttaggatgttag1440gacgatcctgcgccctgccctctcctgtgtacatattgccttcagtacccctcccccacc1500ccatgccacacactgcccctcattagaggccgcactgtatggctgtgtatctgctatgta1560aatgctgagacccctgagtgctgcatgcaggtttcatgttctttctaagatgaaaagaga1620aagtaataaaatatatttgaagttccccaaaaaaaaaaaaaaa1663<210>371<211>568<212>DNA<213>人<400>371ccgtcagtctagaaggataagagaaagaaagttaagcaactacaggaaatggctttggga60gttccaatatcagtctatcttttattcaacgcaatgacagcactgaccgaagaggcagcc120gtgactgtaacacctccaatcacagcccagcaaggtaactggacagttaacaaaacagaa180gctgacaacatagaaggacccatagccttgaagttctcacacctttgcctggaagatcat240aacagttactgcatcaacggtgcttgtgcattccaccatgagctagagaaagccatctgc300aggtgtctaaaattgaaatcgccttacaatgtctgttctggagaaagacgaccactgtga360ggcctttgtgaagaattttcatcaaggcatctgtagagatcagtgagcccaaaattaaag420ttttcagatgaaacaacaaaacttgtcaagctgactagactcgaaaataatgaaagttgg480gatcacaatgaaatgagaagataaaattcagcgttggcctttagactttgccatccttaa540ggagtgatggaagccaagtgaacaagcc568<210>372<211>5583<212>DNA<213>大鼠<400>372ctggtgcagagcgtcgccaaggacgccgggagggaggcgggattgccaagatatcctcca60gtgaagtgcatgtgtgtgtgcaaaccatccttggctgtcgcgaagcagagaagacggctt120ggggctgctgctgtgccgcaggagtggagagaccccgtgagctgagccctgcgccccgca180tcaccgctcggcgcccccaaggctgcctgaatacccggtgcgccccggcgcgcgacatga240ccagtctctccgagggctctgctttggacctgccaggcccttgcgccttctagcttcggg300gggaatccactttgatcagggccaccattactgttaaagccccctcctcagccttgtact360cttcccactggaatcggatttgctagagggtgccgtggaatcggaagtcctcccttgtcc420tcaagcaaccagcctctgcatcttcgcggacactgcaagtaggagctcttttaccaccaa480gttgaagtcgcgctctgtcctcacagctgcttcggggtctaccccaagcctgagtcgggc540ctattgatattcaggacctgaagttgcccacggatcttgtgctctgctagaaaggcttgg600agagcggaggaaagacgtgtgcttctgtctgctctcctgccccatatcactgttccatat660tactgtgtgagcatctctccgggtgctgtgggctgcaagaccagcgccaggaactgggcc720tcggacaccgtccacttttcacgcaaccgaaagctaaagtccctcaaagcaaggggtctg780ttgggaagatgagtggcattggctggcagacactgtccctatctctggcgttagtgttgt840cgatcttgaacaaggtggcgcctcatgcgtgcccggcccagtgctcctgttcaggcagca900cagtggactgtcatgggctggcactgcgcagtgtgcccaggaatatcccccgcaacacgg960agagactggatttgaatggaaataacatcacaaggatcacgaagacagattttgcgggtc1020tcagacacctcagagttcttcagctcatggagaacaagatcagcaccatcgagaggggag1080cattccaggatcttaaggagctagaaagactgcgtttaaacagaaataaccttcagttgt1140ttcctgagctgctgtttcttgggactgcgaagctctaccggcttgatctcagtgaaaatc1200agattcaagcaattccaaggaaggctttccgtggtgcagttgacattaaaaatctgcagt1260tggattacaaccagatcagctgcattgaagatggggcattccgagctctgcgagatctgg1320aagtgctcactctgaacaataacaatattactagactttcagtggcaagtttcaaccata1380tgcctaaacttaggacatttcgactccactccaacaacctatactgcgactgccacctgg1440cctggctctcggactggcttcgccaaaggccacgggtgggcttgtacactcagtgtatgg1500gcccatcccacctgaggggccataatgtagcagaggttcaaaaacgagagtttgtctgca1560gtggtcaccagtcattcatggctccctcctgcagtgtgctgcactgcccgattgcttgta1620cctgtagcaacaacattgtagactgccgagggaaaggtctcactgagatccccacaaatc1680tgcctgagaccatcacagaaatacgtttggaacagaactccataagggtcatccctccag1740gagcattctcaccatacaaaaagcttcgacgactagacctgagtaataaccagatctcgg1800aacttgctccagatgccttccaaggactgcgttctctgaattcccttgtcctgtatggaa1860ataaaatcacagaactcccaaaaagtttatttgaaggactgttttccttacagctactat1920tattgaatgccaacaagataaactgccttcgggtagatgcttttcaggacctgcacaact1980tgaaccttctctccttatacgacaataagcttcagactgttgccaagggcaccttctcag2040ctctcagagccatccaaactatgcatttggcccagaatcctttcatttgtgactgccatc2100tcaagtggctagcggattatctccacaccaacccaattgagaccagcggtgcccgttgca2160ccagtccccgccgcctggctaacaaaagaattggacagatcaaaagcaagaaattccgtt2220gttcagctaaagagcagtatttcattccaggtacagaagattatcgatcaaaattaagtg2280gagactgctttgcagacttggcttgtcctgaaaaatgtcgctgtgaagggaccacagtag2340actgctccaatcaaaaactcaacaaaatcccagaccatattccccagtacacagcagagc2400tgcgtctcaataataatgaattcacagtgttagaagccacgggaatatttaagaaacttc2460ctcaattgcgtaaaatcaaccttagcaacaataagatcactgatatcgaggagggggcat2520tcgaaggtgcgtctggtgtgaatgagattctgcttaccagtaaccgtttggaaaatgttc2580agcataagatgttcaaaggattggagagcctcaaaacattgatgctgagaagtaatcgaa2640taagctgtgtgggaaacgacagtttcacaggactcggttctgtgcgtctgctctctttat2700atgacaatcaaattaccacagttgcaccaggagcatttggtactctccattcattatcta2760cactaaacctcttggccaatcctttcaactgtaactgtcacctggcatggcttggagaat2820ggctcagaaggaaaagaattgtaacaggaaatcctcgatgccaaaaaccctacttcttga2880aggaaataccaatccaggatgtagccattcaggacttcacctgtgatgacggaaacgatg2940ataatagctgctctccactctcccgttgtccttcggaatgtacttgcttggatacagtag3000tacgatgtagcaacaagggcttgaaggtcttacctaaaggcattccaagagatgtcacag3060aactgtatctggatgggaaccagtttacactggtcccgaaggaactctccaactacaaac3120atttaacacttatagacttaagtaacaacagaataagcaccctttccaaccaaagcttca3180gcaacatgacccaacttctcaccttaattctcagttacaaccgtctgagatgtatccctc3240cacggacctttgatggattgaaatctcttcgtttactgtctctacatggaaatgacattt3300ctgtcgtgcctgaaggtgcctttggtgacctttcagccttgtcacacttagcaattggag3360ccaaccctct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CysValGlyAspCysLeuCysLeu354045SerAspProLeuTrpLeuCysLeuLeuLysGluThrGluThrProCys505560GlyPheLeuSer65<210>377<211>107<212>蛋白质<213>大鼠<400>377MetProPheArgLeuLeuIleProLeuGlyLeuValCysValLeuLeu151015ProLeuHisHisGlyAlaProGlyProGluGlyThrAlaProAspPro202530AlaHisTyrArgGluArgValLysAlaMetPheTyrHisAlaTyrAsp354045SerTyrLeuGluAsnAlaPheProTyrAspGluLeuArgProLeuThr505560CysAspGlyHisAspThrTrpGlySerPheSerLeuThrLeuIleAsp65707580AlaLeuAspThrLeuLeuIleLeuGlyAsnThrSerGluPheGlnArg859095ValValGluValLeuGlnAspLysArgGlyLeu100105<210>378<211>95<212>蛋白质<213>大鼠<400>378MetTrpPheLeuProCysSerValProLeuValIleSerSerCysHis151015SerGlnAlaSerProHisTrpProTyrGlyIleIleSerGlyGlyGln202530GluGlyLeuCysArgLeuTrpThrAlaThrCysHisSerArgGlyGlu354045SerGluValSerArgSerSerArgLysGluAspProArgIleProGln505560GlySerLeuSerGlyAsnValAspPheTrpArgValCysProProCys65707580AlaHisThrSerMetAspArgThrLeuGlyLeuLeuSerCysCys859095<210>379<211>138<212>蛋白质<213>小鼠<400>379MetAspLeuAspValValAsnMetPheValIleAlaGlyGlyThrLeu151015AlaIleProIleLeuAlaPheValAlaSerPheLeuLeuTrpProSer202530AlaLeuIleArgIleTyrTyrTrpTyrTrpArgArgThrLeuGlyMet354045GlnValArgTyrAlaHisHisGluAspTyrGlnPheCysTyrSerPhe505560ArgGlyArgProGlyHisLysProSerIleLeuMetLeuHisGlyPhe65707580SerAlaHisLysAspMetTrpLeuSerValValLysPheLeuProLys859095AsnLeuHisLeuValCysValAspMetProGlyHisGluGlyThrThr100105110ArgSerSerLeuAspAspLeuSerIleValGlyGlnValLysArgIle115120125HisGlnPheValGluCysLeuLysLeuAsn130135<210>380<211>81<212>蛋白质<213>大鼠<400>380MetAlaSerSerSerAsnTrpLeuSerGlyValAsnValValLeuVal151015MetAlaTyrGlySerLeuValPheValLeuLeuPheIlePheValLys202530ArgGlnIleMetArgPheAlaMetLysSerArgArgGlyProHisVal354045ProValGlyHisAsnAlaProLysAspLeuLysGluGluIleAspIle505560ArgLeuSerArgValGlnAspIleLysTyrGluProGlnLeuLeuAla65707580Asp<210>381<211>257<212>蛋白质<213>小鼠<400>381MetArgSerGlyAlaLeuTrpProLeuLeuTrpGlyAlaLeuValTrp151015ThrValGlySerValGlyAlaValMetGlySerGluAspSerValPro202530GlyGlyValCysTrpLeuGlnGlnGlyArgGluAlaThrCysSerLeu354045ValLeuLysThrArgValSerArgGluGluCysCysAlaSerGlyAsn505560IleAsnThrAlaTrpSerAsnPheThrHisProGlyAsnLysIleSer65707580LeuLeuGlyPheLeuGlyLeuValHisCysLeuProCysLysAspSer859095CysAspGlyValGluCysGlyProGlyLysAlaCysArgMetLeuGly100105110GlyArgProThrLeuArgSerCysValProAsnCysGluGlyLeuPro115120125AlaGlyPheGlnValCysGlySerAspGlyAlaThrTyrArgAspGlu130135140CysGluLeuArgThrAlaArgCysArgGlyHisProAspLeuArgVal145150155160MetTyrArgGlyArgCysGlnLysSerCysAlaGlnValValCysPro165170175ArgProGlnSerCysLeuValAspGlnThrGlySerAlaHisCysVal180185190ValCysArgAlaAlaProCysProValProSerAsnProGlyGlnGlu195200205LeuCysGlyAsnAsnAsnValThrTyrIleSerSerCysHisLeuArg210215220GlnAlaThrCysPheLeuGlyArgSerIleGlyValArgHisProGly225230235240IleCysThrGlyGlyProLysValProAlaGluGluGluGluAsnPhe245250255Val<210>382<211>285<212>蛋白质<213>大鼠<400>382MetIleSerTrpMetLeuLeuAlaCysAlaLeuProCysAlaAlaAsp151015ProMetLeuGlyAlaPheAlaArgArgAspPheGlnLysGlyGlyPro202530GlnLeuValCysSerLeuProGlyProGlnGlyProProGlyProPro354045GlyAlaProGlySerSerGlyMetValGlyArgMetGlyPheProGly505560LysAspGlyGlnAspGlyGlnAspGlyAspArgGlyAspSerGlyGlu65707580GluGlyProProGlyArgThrGlyAsnArgGlyLysGlnGlyProLys859095GlyLysAlaGlyAlaIleGlyArgAlaGlyProArgGlyProLysGly100105110ValSerGlyThrProGlyLysHisGlyIleProGlyLysLysGlyPro115120125LysGlyLysLysGlyGluProGlyLeuProGlyProCysSerCysGly130135140SerSerArgAlaLysSerAlaPheSerValSerValThrLysSerTyr145150155160ProArgGluArgLeuProIleLysPheAspLysIleLeuMetAsnGlu165170175GlyGlyHisTyrAsnAlaSerSerGlyLysPheValCysSerValPro180185190GlyIleTyrTyrPheThrTyrAspIleThrLeuAlaAsnLysHisLeu195200205AlaIleGlyLeuValHisAsnGlyGlnTyrArgIleArgThrPheAsp210215220AlaAsnThrGlyAsnHisAspValAlaSerGlySerThrIleLeuAla225230235240LeuLysGluGlyAspGluValTrpLeuGlnIlePheTyrSerGluGln245250255AsnGlyLeuPheTyrAspProTyrTrpThrAspSerLeuPheThrGly260265270PheLeuIleTyrAlaAspGlnGlyAspProAsnGluVal275280285<210>383<211>183<212>蛋白质<213>大鼠<400>383MetLysLeuLeuCysLeuValAlaValValGlyCysLeuLeuValPro151015ProAlaGlnAlaAsnLysSerSerGluAspIleArgCysLysCysIle202530CysProProTyrArgAsnIleSerGlyHisIleTyrAsnGlnAsnVal354045SerGlnLysAspCysAsnCysLeuHisValValGluProMetProVal505560ProGlyHisAspValGluAlaTyrCysLeuLeuCysGluCysArgTyr65707580GluGluArgSerThrThrThrIleLysValIleIleValIleTyrLeu859095SerValValGlyAlaLeuLeuLeuTyrMetAlaPheLeuMetLeuVal100105110AspProLeuIleArgLysProAspAlaTyrThrGluGlnLeuHisAsn115120125GluGluGluAsnGluAspAlaArgSerMetAlaAlaAlaAlaAlaSer130135140IleGlyGlyProArgAlaAsnThrValLeuGluArgValGluGlyAla145150155160GlnGlnArgTrpLysLeuGlnValGlnGluGlnArgLysThrValPhe165170175AspArgHisLysMetLeuSer180<210>384<21l>292<212>蛋白质<213>小鼠<400>384CysGlnLeuProLeuArgValLeuIleIleSerAsnAsnLysLeuGly151015AlaLeuProProAspIleSerThrLeuGlySerLeuArgGlnLeuAsp202530ValSerSerAsnGluLeuGlnSerLeuProValGluLeuCysSerLeu354045ArgSerLeuArgAspLeuAsnValArgArgAsnGlnLeuSerThrLeu505560ProAspGluLeuGlyAspLeuProLeuValArgLeuAspPheSerCys65707580AsnArgIleSerArgIleProValSerPheCysArgLeuArgHisLeu859095GlnValValLeuLeuAspSerAsnProLeuGlnSerProProAlaGln100105110IleCysLeuLysGlyLysLeuHisIlePheLysTyrLeuThrMetGlu115120125AlaGlyArgArgGlyAlaAlaLeuGlyAspLeuValProSerArgPro130135140ProSerPheSerProCysProAlaGluAspLeuPheProGlyArgArg145150155160TyrAspGlyGlyLeuAspSerGlyPheHisSerValAspSerGlySer165170175LysArgTrpSerGlyAsnGluSerThrAspAspPheSerGluLeuSer180185190PheArgIleSerGluLeuAlaArgAspProArgGlyProArgGlnPro195200205ArgGluAspGlyAlaGlyAspGlyAspLeuGluGlnIleAspPheIle210215220AspSerHisValProGlyGluAspGluAspArgSerAlaAlaGluGlu225230235240GlnLeuProSerGluLeuSerLeuValAlaGlyAspValGluLysPro245250255SerSerSerArgArgGluGluProAlaGlyGluGluArgArgArgPro260265270AspThrLeuGlnLeuTrpGlnGluArgGluArgLysGlnGlnGlnGln275280285SerGlyGlyTrp290<210>385<211>164<212>蛋白质<213>小鼠<400>385SerArgGlnLeuArgAlaProArgPheAspProArgAlaGlyPheHis151015AlaGluGlyLysAspArgGlyProSerValProGlnGlyLeuLeuLys202530AlaAlaArgSerSerGlyGlnLeuAsnLeuAlaGlyArgAsnLeuGly354045GluValProGlnCysValTrpArgIleAsnValAspIleProGluGlu505560AlaAsnGlnAsnLeuSerPheSerSerThrGluArgTrpTrpAspGln65707580ThrAspLeuThrLysLeuIleIleSerSerAsnLysLeuGlnSerLeu859095SerAspAspLeuArgLeuLeuProAlaLeuThrValLeuAspIleHis100105110AspAsnGlnLeuThrSerLeuProSerAlaIleArgGluLeuAspAsn115120125LeuGlnLysLeuAsnValSerHisAsnLysLeuLysIleLeuProGlu130135140GluIleThrSerLeuLysAsnLeuArgThrLeuHisLeuGlnHisAsn145150155160GluLeuThrCys<210>386<211>71<212>蛋白质<213>小鼠<400>386SerLeuSerIleLeuProAlaValArgValSerProArgProThrTyr151015ProSerThrAlaSerSerMetAlaAlaPheLeuValThrGlyPhePhe202530PheSerLeuPheValValLeuGlyMetGluProArgAlaLeuPheArg354045ProAspLysAlaLeuProLeuSerCysAlaLysProThrSerLeuCys505560ValGlnSerSerPheLeuGly6570<210>387<211>126<212>蛋白质<213>小鼠<400>387GluTyrGluAlaArgValLeuGluLysSerLeuArgLysGluSerArg151015AsnLysGluThrAspLysValLysLeuThrTrpArgAspArgPhePro202530AlaTyrPheThrAsnLeuValSerIleIlePheMetIleAlaValThr354045PheAlaIleValLeuGlyValIleIleTyrArgIleSerThrAlaAla505560AlaLeuAlaMetAsnSerSerProSerValArgSerAsnIleArgVal65707580ThrValThrAlaThrAlaValIleIleAsnLeuValValIleIleLeu859095LeuAspGluValTyrGlyCysIleAlaArgTrpLeuThrLysIleGly100105110GluCysHisValGlnAspSerIleGlySerMetGlyLeuGly115120125<210>388<211>84<212>蛋白质<213>大鼠<400>388AlaAlaGluAsnGluMetProValAlaValGlyProTyrGlyGlnSer151015GlnProSerCysPheAspArgValLysMetGlyPheValMetGlyCys202530AlaValGlyMetAlaAlaGlyAlaLeuPheGlyThrPheSerCysLeu354045ArgIleGlyMetArgGlyArgGluLeuMetGlyGlyIleGlyLysThr505560MetMetGlnSerGlyGlyThrPheGlyThrPheMetAlaIleGlyMet65707580GlyIleArgCys<210>389<211>284<212>蛋白质<213>大鼠<400>389GlyGlySerSerValSerHisValLeuArgGlySerGlyGlnGluArg151015SerProProProAlaSerMetGlnProProTrpGlyLeuAlaLeuPro202530LeuLeuLeuProTrpValAlaGlyGlyValGlyThrSerProArgAsp354045TyrTrpLeuProAlaLeuAlaHisGlnProGlyValCysHisTyrGly505560ThrLysThrAlaCysCysTyrGlyTrpLysArgAsnSerLysGlyVal65707580CysGluAlaValCysGluProArgCysLysPheGlyGluCysValGly859095ProAsnLysCysArgCysPheProGlyTyrThrGlyLysThrCysSer100105110GlnAspValAsnGluCysAlaPheLysProArgProCysGlnHisArg115120125CysValAsnThrHisGlySerTyrLysCysPheCysLeuSerGlyHis130135140MetLeuLeuProAspAlaThrCysSerAsnSerArgThrCysAlaArg145150155160IleAsnCysGlnTyrSerCysGluAspThrAlaGluGlyProArgCys165170175ValCysProSerSerGlyLeuArgLeuGlyProAsnGlyArgValCys180185190LeuAspIleAspGluCysAlaSerSerLysAlaValCysProSerAsn195200205ArgArgCysValAsnThrPheGlySerTyrTyrCysLysCysHisIle210215220GlyPheGluLeuLysTyrIleSerArgArgTyrAspCysValAspIle225230235240AsnGluCysThrLeuAsnThrArgThrCysSerProHisAlaAsnCys245250255LeuAsnThrGlnGlySerPheLysCysLysCysLysGlnGlyTyrArg260265270GlyAsnGlyLeuGlnCysSerValIleProGluHis275280<210>390<211>85<212>蛋白质<213>大鼠<400>390GlyAlaProMetTyrPheSerGluGlyArgGluArgGlyLysValTyr151015ValTyrAsnLeuArgGlnAsnArgPheValPheAsnGlyThrLeuLys202530AspSerHisSerTyrGlnAsnAlaArgPheGlySerCysIleAlaSer354045ValGlnAspLeuAsnGlnAspSerTyrAsnAspValValValGlyAla505560ProGlnGluAspSerHisArgGlyAlaIleTyrIlePheHisGlyPhe65707580GlnThrAsnIleLeu85<210>391<211>158<212>蛋白质<213>大鼠<400>391PheGlnThrAsnIleLeuLysLysProValGlnArgIleSerAlaSer151015GluLeuAlaProGlyLeuGlnHisPheGlyCysSerIleHisGlyGln202530LeuAspLeuAsnGluAspGlyLeuValAspLeuAlaValGlyAlaLeu354045GlyAsnAlaValValLeuTrpAlaArgProValValGlnIleAsnAla505560SerLeuHisPheGluProSerLysIleAsnIlePheHisLysAspCys65707580LysArgAsnGlyArgAspAlaThrCysLeuAlaAlaPheLeuCysPhe859095GlyProIlePheLeuAlaProHisPheHisThrAlaThrValGlyIle100105110ArgTyrAsnAlaThrMetAspGluArgArgTyrMetProArgAlaHis115120125LeuAspGluGlyAlaAspGlnPheThrAsnArgAlaValLeuLeuSer130135140SerGlyGlnGluHisCysGlnArgIleAsnPheHisValLeu145150155<210>392<211>124<212>蛋白质<213>小鼠<400>392AlaAlaGluGlnGluAlaSerSerArgArgArgArgGlyGlyAlaGly151015ProAlaLeuPheSerSerGlySerLeuArgSerGluProGlnProArg202530LeuProGlnAlaArgSerArgProArgProSerPheLeuGlnAlaArg354045SerArgProCysLeuSerGlnAlaCysSerProAlaAlaSerValLeu505560SerSerSerSerLeuCysGlyArgSerHisLeuLeuProGlySerLeu65707580ProAlaThrAlaPheLeuLeuLeuLeuProGlySerLeuProGlyArg859095ArgProSerAlaAlaGlnAlaAlaProValLeuAlaTrpGlyLeuVal100105110AlaPheGlnLeuGlyValAlaAlaGlyAlaGlyArg115120<210>393<211>242<212>蛋白质<213>大鼠<400>393GlyHisCysAspCysGlnAlaGlyTyrGlyGlyGluAlaCysGlyGln151015CysGlyLeuGlyTyrPheGluAlaGluArgAsnSerSerHisLeuVal202530CysSerAlaCysPheGlyProCysAlaArgCysThrGlyProGluGlu354045SerHisCysLeuGlnCysArgLysGlyTrpAlaLeuHisHisLeuLys505560CysValAspIleAspGluCysGlyThrGluGlnAlaThrCysGlyAla65707580AspGlnPheCysValAsnThrGluGlySerTyrGluCysArgAspCys859095AlaLysAlaCysLeuGlyCysMetGlyAlaGlyProGlyProCysLys100105110LysCysSerArgGlyTyrGlnGlnValGlySerLysCysLeuAspVal115120125AspGluCysGluThrValValCysProGlyGluAsnGluGlnCysGlu130135140AsnThrGluGlySerTyrArgCysValCysAlaGluGlyPheArgGln145150155160GluAspGlyIleCysValLysGluGlnIleProGluSerAlaGlyPhe165170175PheAlaGluMetThrGluAspGluMetValValLeuGlnGlnMetPhe180185190PheGlyValIleIleCysAlaLeuAlaThrLeuAlaAlaLysGlyAsp195200205LeuValPheThrAlaIlePheIleGlyAlaValAlaAlaMetThrGly210215220TyrTrpLeuSerGluArgSerAspArgValLeuGluGlyPheIleLys225230235240GlyArg<210>394<211>99<212>蛋白质<213>小鼠<400>394MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysSerMetSer505560ArgTyrArgGlyGlnGluHisCysLeuHisProLysLeuGlnSerThr65707580LysArgPheIleLysTrpTyrAsnAlaTrpAsnGluLysArgArgVal859095TyrGluGlu<210>395<211>103<212>蛋白质<213>人<400>395MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnGlyAsnTrpThrValAsnLysThrGluAlaAspAsnIle354045GluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGluAspHis505560AsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuGlu65707580LysAlaIleCysArgCysLeuLysLeuLysSerProTyrAsnValCys859095SerGlyGluArgArgProLeu100<210>396<211>1529<212>蛋白质<213>大鼠<400>396MetSerGlyIleGlyTrpGlnThrLeuSerLeuSerLeuAlaLeuVal151015LeuSerIleLeuAsnLysValAlaProHisAlaCysProAlaGlnCys202530SerCysSerGlySerThrValAspCysHisGlyLeuAlaLeuArgSer354045ValProArgAsnIleProArgAsnThrGluArgLeuAspLeuAsnGly505560AsnAsnIleThrArgIleThrLysThrAspPheAlaGlyLeuArgHis65707580LeuArgValLeuGlnLeuMetGluAsnLysIleSerThrIleGluArg859095GlyAlaPheGlnAspLeuLysGluLeuGluArgLeuArgLeuAsnArg100105110AsnAsnLeuGlnLeuPheProGluLeuLeuPheLeuGlyThrAlaLys115120125LeuTyrArgLeuAspLeuSerGluAsnGlnIleGlnAlaIleProArg130135140LysAlaPheArgGlyAlaValAspIleLysAsnLeuGlnLeuAspTyr145150155160AsnGlnIleSerCysIleGluAspGlyAlaPheArgAlaLeuArgAsp165170175LeuGluValLeuThrLeuAsnAsnAsnAsnIleThrArgLeuSerVal180185190AlaSerPheAsnHisMetProLysLeuArgThrPheArgLeuHisSer195200205AsnAsnLeuTyrCysAspCysHisLeuAlaTrpLeuSerAspTrpLeu210215220ArgGlnArgProArgValGlyLeuTyrThrGlnCysMetGlyProSer225230235240HisLeuArgGlyHisAsnValAlaGluValGlnLysArgGluPheVal245250255CysSerGlyHisGlnSerPheMetAlaProSerCysSerValLeuHis260265270CysProIleAlaCysThrCysSerAsnAsnIleValAspCysArgGly275280285LysGlyLeuThrGluIleProThrAsnLeuProGluThrIleThrGlu290295300IleArgLeuGluGlnAsnSerIleArgValIleProProGlyAlaPhe305310315320SerProTyrLysLysLeuArgArgLeuAspLeuSerAsnAsnGlnIle325330335SerGluLeuAlaProAspAlaPheGlnGlyLeuArgSerLeuAsnSer340345350LeuValLeuTyrGlyAsnLysIleThrGluLeuProLysSerLeuPhe355360365GluGlyLeuPheSerLeuGlnLeuLeuLeuLeuAsnAlaAsnLysIle370375380AsnCysLeuArgValAspAlaPheGlnAspLeuHisAsnLeuAsnLeu385390395400LeuSerLeuTyrAspAsnLysLeuGlnThrValAlaLysGlyThrPhe405410415SerAlaLeuArgAlaIleGlnThrMetHisLeuAlaGlnAsnProPhe420425430IleCysAspCysHisLeuLysTrpLeuAlaAspTyrLeuHisThrAsn435440445ProIleGluThrSerGlyAlaArgCysThrSerProArgArgLeuAla450455460AsnLysArgIleGlyGlnIleLysSerLysLysPheArgCysSerAla465470475480LysGluGlnTyrPheIleProGlyThrGluAspTyrArgSerLysLeu485490495SerGlyAspCysPheAlaAspLeuAlaCysProGluLysCysArgCys500505510GluGlyThrThrValAspCysSerAsnGlnLysLeuAsnLysIlePro515520525AspHisIleProGlnTyrThrAlaGluLeuArgLeuAsnAsnAsnGlu530535540PheThrValLeuGluAlaThrGlyIlePheLysLysLeuProGlnLeu545550555560ArgLysIleAsnLeuSerAsnAsnLysIleThrAspIleGluGluGly565570575AlaPheGluGlyAlaSerGlyValAsnGluIleLeuLeuThrSerAsn580585590ArgLeuGluAsnValGlnHisLysMetPheLysGlyLeuGluSerLeu595600605LysThrLeuMetLeuArgSerAsnArgIleSerCysValGlyAsnAsp610615620SerPheThrGlyLeuGlySerValArgLeuLeuSerLeuTyrAspAsn625630635640GlnIleThrThrValAlaProGlyAlaPheGlyThrLeuHisSerLeu645650655SerThrLeuAsnLeuLeuAlaAsnProPheAsnCysAsnCysHisLeu660665670AlaTrpLeuGlyGluTrpLeuArgArgLysArgIleValThrGlyAsn675680685ProArgCysGlnLysProTyrPheLeuLysGluIleProIleGlnAsp690695700ValAlaIleGlnAspPheThrCysAspAspGlyAsnAspAspAsnSer705710715720CysSerProLeuSerArgCysProSerGluCysThrCysLeuAspThr725730735ValValArgCysSerAsnLysGlyLeuLysValLeuProLysGlyIle740745750ProArgAspValThrGluLeuTyrLeuAspGlyAsnGlnPheThrLeu755760765ValProLysGluLeuSerAsnTyrLysHisLeuThrLeuIleAspLeu770775780SerAsnAsnArgIleSerThrLeuSerAsnGlnSerPheSerAsnMet785790795800ThrGlnLeuLeuThrLeuIleLeuSerTyrAsnArgLeuArgCysIle805810815ProProArgThrPheAspGlyLeuLysSerLeuArgLeuLeuSerLeu820825830HisGlyAsnAspIleSerValValProGluGlyAlaPheGlyAspLeu835840845SerAlaLeuSerHisLeuAlaIleGlyAlaAsnProLeuTyrCysAsp850855860CysAsnMetGlnTrpLeuSerAspTrpValLysSerGluTyrLysGlu865870875880ProGlyIleAlaArgCysAlaGlyProGlyGluMetAlaAspLysLeu885890895LeuLeuThrThrProSerLysLysPheThrCysGlnGlyProValAsp900905910ValThrIleGlnAlaLysCysAsnProCysLeuSerAsnProCysLys915920925AsnAspGlyThrCysAsnAsnAspProValAspPheTyrArgCysThr930935940CysProTyrGlyPheLysGlyGlnAspCysAspValProIleHisAla945950955960CysIleSerAsnProCysLysHisGlyGlyThrCysHisLeuLysGlu965970975GlyGluAsnAspGlyPheTrpCysThrCysAlaAspGlyPheGluGly980985990GluSerCysAspIleAsnIleAspAspCysGluAspAsnAspCysGlu99510001005AsnAsnSerThrCysValAspGlyIleAsnAsnTyrThrCysLeuCys101010151020ProProGluTyrThrGlyGluLeuCysGluGluLysLeuAspPheCys102510301035104AlaGlnAspLeuAsnProCysGlnHisAspSerLysCysIleLeuThr104510501055ProLysGlyPheLysCysAspCysThrProGlyTyrIleGlyGluHis106010651070CysAspIleAspPheAspAspCysGlnAspAsnLysCysLysAsnGly107510801085AlaHisCysThrAspAlaValAsnGlyTyrThrCysValCysProGlu109010951100GlyTyrSerGlyLeuPheCysGluPheSerProProMetValLeuLeu110511101115112ArgThrSerProCysAspAsnPheAspCysGlnAsnGlyAlaGlnCys112511301135IleIleArgValAsnGluProIleCysGlnCysLeuProGlyTyrLeu114011451150GlyGluLysCysGluLysLeuValSerValAsnPheValAsnLysGlu115511601165SerTyrLeuGlnIleProSerAlaLysValArgProGlnThrAsnIle117011751180ThrLeuGlnIleAlaThrAspGluAspSerGlyIleLeuLeuTyrLys118511901195120GlyAspLysAspHisIleAlaValGluLeuTyrArgGlyArgValArg120512101215AlaSerTyrAspThrGlySerHisProAlaSerAlaIleTyrSerVal122012251230GluThrIleAsnAspGlyAsnPheHisIleValGluLeuLeuThrLeu123512401245AspSerSerLeuSerLeuSerValAspGlyGlySerProLysIleIle125012551260ThrAsnLeuSerLysGlnSerThrLeuAsnPheAspSerProLeuTyr126512701275128ValGlyGlyMetProGlyLysAsnAsnValAlaSerLeuArgGlnAla128512901295ProGlyGlnAsnGlyThrSerPheHisGlyCysIleArgAsnLeuTyr130013051310IleAsnSerGluLeuGlnAspPheArgLysValProMetGlnThrGly131513201325IleLeuProGlyCysGluProCysHisLysLysValCysAlaHisGly133013351340ThrCysGlnProSerSerGlnSerGlyPheThrCysGluCysGluGlu134513501355136GlyTrpMetGlyProLeuCysAspGlnArgThrAsnAspProCysLeu136513701375GlyAsnLysCysValHisGlyThrCysLeuProIleAsnAlaPheSer138013851390TyrSerCysLysCysLeuGluGlyHisGlyGlyValLeuCysAspGlu139514001405GluGluAspLeuPheAsnProCysGlnValIleLysCysLysHisGly141014151420LysCysArgLeuSerGlyLeuGlyGlnProTyrCysGluCysSerSer142514301435144GlyPheThrGlyAspSerCysAspArgGluIleSerCysArgGlyGlu144514501455ArgIleArgAspTyrTyrGlnLysGlnGlnGlyTyrAlaAlaCysGln146014651470ThrThrLysLysValSerArgLeuGluCysArgGlyGlyCysAlaGly147514801485GlyGlnCysCysGlyProLeuArgSerLysArgArgLysTyrSerPhe149014951500GluCysThrAspGlySerSerPheValAspGluValGluLysValVal150515101515152LysCysGlyCysThrArgCysAlaSer1525<210>397<211>8<212>蛋白质<213>小鼠<400>397TrpTyrAsnAlaTrpAsnGluLys15<210>398<211>7<212>蛋白质<213>小鼠<400>398MetValIleIleThrThrLys15<210>399<211>2206<212>DNA<213>大鼠<400>399gtttcgtcttaacgccctctctgcgttggcagaactggccgtgggctcccgctggtacca60tggaacatctcagcccacacagactaagcggagactgatgttggtggcgttcctcggagc120atccgcggtgactgcaagtaccggtctcctgtggaagaaggctcacgcagaatctccacc180gagcgtcaacagcaagaagactgacgctggagataaggggaagagcaaggacacccggga240agtgtccagccatgaaggaagcgctgcagacactgcggccgagccttacccagaggagaa300gaagaagaagcgttctggattcagagacagaaaagtaatggagtatgagaataggatccg360agcctactccacaccagacaaaatcttccggtattttgccaccttgaaagtaatcaacga420acctggtgaaactgaagtgttcatgaccccacaggactttgtgcgctccataacacccaa480tgagaagcagccagaacacttgggcctggatcagtacataataaagcgcttcgatggaaa540gaaaattgcccaggaacgagaaaagtttgctgacgaaggcagcatcttctatacccttgg600agagtgtggactcatctccttctctgactacatcttcctcacaacggtgctctccactcc660tcagagaaatttcgaaattgccttcaagatgtttgacttgaatggagatggagaagtaga720catggaggagtttgagcaggttcaaagcatcattcgctcccagaccagcatgggcatgcg780tcacagagatcgtccaactactgggaacaccctcaagtctggcttatgttcggccctcac840gacctacttttttggagctgatctcaaagggaaactgaccattaaaaacttcctggaatt900tcagcgtaaactgcagcatgacgttctaaagctggagtttgaacgccatgacccggtaga960cgggagaatctctgagaggcagttcggtggcatgctgctggcctacagtggagtgcagtc1020caagaagctgaccgccatgcagaggcagctgaagaagcacttcaaggatgggaagggcct1080gactttccaggaggtggagaacttcttcactttcctgaagaacattaatgacgtggacac1140tgcgttaagcttttaccacatggctggagcatccctcgataaagtgaccatgcagcaagt1200ggccaggacagtggcgaaagtcgagctgtcggaccacgtgtgtgacgtggtgtttgcact1260ctttgactgcgacggcaatggggagctgagcaataaggagtttgtctccatcatgaagca1320gcggctgatgagaggcctggagaagcccaaggacatgggctttacccgtctcatgcaggc1380catgtggaaatgtgcccaagaaaccgcctgggactttgctctacccaaatagtaccccac1440ctcctgcaccttagcaccccgcaatcctggagtggccttcatgctgctgatgcttctggg1500agtagtgcccacatccccatctttctggaagtgacctctggcctcagctggctgacctct1560ccatcctcccctgacccagtcagtgttccgctaggctctgaatctgcagtcagatcaaag1620gtctaagacaggaacaagtcttcaaagcagagaccatagctcccttaaccagtgccccgt1680gggtaaatgcggggagccctcccacactggcagccccaggaggcatctctgcagtctctc1740actgtggatttaagtaacacaaacgtccctgccatcttcctcccactgttttaaagctgc1800aagtttggaaatactctggcaggcaaagggaagtctgtgatgaacggtaatgcagatgac1860cctggtaccctgatctggcagggcacctggtcaggggaagggtctgcgtcagacaccagc1920ggcaccaggaaggctctttgccaccagcacagctcccgattcaaagtcgctgctttgagc1980ggctctccagaacctcctgctcttttttttttcctcccggctccctgcgatgcctcctct2040gggactctgcttcactagagccagggctgagcccctgttccttgtgtcttgtcccctctc2100tatagacctgcagagcgcagctcagagcctatctgccctctgtctaatacactcgtaaat2160atcactttaattatagcactttgcaggaaataccccaaaaaaaaaa2206<210>400<211>160<212>DNA<213>小鼠<400>400tcgcaggacgctcactggacagcttgggcttttttcagttgattttatggtttgcatctt60tctctttctctttttctgtttcttgttcccctttccccttttcctggtgagaaagcacat120attactgagccattgcaagcaatgggaggggtccacaatg160<210>401<211>430<212>DNA<213>大鼠<400>401ggcaccagcccggcttctgtgctccgctcagtctccagcgatccctccctacctccgccc60tccatggcgtcgctcctgtgctgtgggcctaagctggccgcctgtggcatcgtcctcagc120gcctggggagtgatcatgttgataatgctcgggatatttttcaatgtccattctgctgtg180ttaattgaggatgtccccttcacagagaaagattttgagaacggccctcagaacatatac240aacctgtacgagcaagtcagctacaactgtttcatcgccgcgggcctctacctcctcctc300gggggcttctccttctgccaagttcgtctcaataagcgcaaggaatacatggtgcgctag360agcgcagtccgactctccccattcccctccttatttaaagactcctcagtccatctgttc420cactcatctg430<210>402<211>190<212>DNA<213>大鼠<400>402ccgaatacgcggccgcgtcgacatactgcctgtagagttagtatttctgttttttatatg60ttgcacactgaattgaagaaatgttggtttttcttgttttgttttagtttgtttctttgg120ttttgtttttggttttgctttttacttcccaggtttgactatttgccaatgccgtcgacg180cggccgcgaa190<210>403<211>1774<212>DNA<213>小鼠<400>403ccaaagtggagggcgagggccggggccggtgggctctggggctgctgcgcaccttcgacg60ccggcgaattcgcaggctgggagaaggtgggctcgggcggcttcgggcaggtgtacaagg120tgcgccatgtgcactggaagacgtggctcgcgatcaagtgctcgcccagtctgcacgtcg180acgacagggaacgaatggagctcctggaggaagctaagaagatggagatggccaagttcc240gatacattctacctgtgtacggcatatgccaggaacctgtcggcttggtcatggagtaca300tggagacaggctccctggagaagctgctggcctcagagccattgccttgggacctgcgct360ttcgcatcgtgcacgagacagccgtgggcatgaacttcctgcattgcatgtctccgccac420tgctgcacctagacctgaagccagcgaacatcctgctggatgcccactaccatgtcaaga480tttctgactttgggctggccaagtgcaatggcatgtcccactctcatgacctcagcatgg540atggcctgtttggtacaatcgcttacctccctccagagcgaattcgtgagaagagccgct600tgtttgacaccaaacatgatgtatacagcttcgccattgtgatctggggtgtgcttacac660agaagaagccatttgcagatgaaaagaacatcctacacatcatgatgaaagtggtaaagg720gccaccgcccagagctgccacccatctgcagaccccggccgcgtgcctgtgccagcctga780tagggataatgcaacggtgctggcatgcagacccacaggtgcggcccaccttccaagaaa840ttacctctgaaacagaagacctttgtgagaagcctgatgaggaggtgaaagacctggctc900atgagccaggcgagaaaagctctctagagtccaagagtgaggccaggcccgagtcctcac960gcctcaagcgcgcctctgctccccccttcgataacgactgcagtctctccgagttgctgt1020cacagttggactctgggatctcccagactcttgaaggccccgaagagctcagccgaagtt1080cctctgaatgcaagctcccatcgtccagcagtggcaagaggctctcgggggtgtcctcag1140tggactcagccttttcctccagaggatcgctgtcactgtcttttgagcgggaagcttcaa1200caggcgacctgggccccacagacatccagaagaagaagctagtggatgccatcatatcag1260gggacaccagcaggctgatgaagatcctacagccccaagatgtggacttggttctagaca1320gcagtgccagcctgctgcacctggctgtggaggccggacaggaggagtgtgtcaagtggc1380tgctgcttaacaatgccaaccccaacctgaccaacaggaagggctctacaccactgcata1440tggctgtggagcggaagggacgtggaattgtggagctactgctagcccggaagaccagtg1500tcaatgccaaggatgaagaccagtggactgccctgcactttgcagcccagaatggggatg1560aggccagcacaaggctgctgctagagaagaatgcttctgtcaatgaggtggactttgagg1620gccgaacacccatgcatgtagcctgccagcatggacaggagaacattgtgcgcaccctgc1680tccgccgtggtgtggatgtgggcctgcagggaaaggatgcctggttgcctctgcactatg1740ctgcctggcaaggccaccttcccattggtaagct1774<210>404<211>372<212>DNA<213>小鼠<400>404ccacagcacatcgtcctgactgtcctcttcccagggaccaagagctagagacccggctgt60gactgcccgcctctggggcttcctttagaggagacagtctttacccatctagactcctgc120caccctgactgctgacttacagctatgaggtcccggcttctgctgcccgtgccccatttg180ccaacgattcgggaaatgtcagaagagctgtcacatggggcagctgggcaggaaccccca240gcgtcccccagcctggatgactacgtcaggtgtatctgtcagctggcacagcccacctca300gtgctggacaaggtcacagcccagagccgtcccaacagaccctcccggccagcctggact360cgagagaagagg372<210>405<211>396<212>DNA<213>小鼠<400>405gagcttcgaagctttctccgtcttccaagacgacaggtttctggggccacaagaggccga60gcctcttcattttgttttcttctccaggctgaagacctgaacgtcaagttggaaggggag120ccttccatgcggaaaccaaagcagcggccgcggccggagcccctcatcatccccaccaag180gcgggcactttcatcgcccctcctgtctactccaacatcaccccttaccagagccacctg240cgctctcccgtgcgccttgctgaccacccctctgagcggagctttgagccccccccttac300acaccaccccccattctcagccccgtccgggaaggctctggcctctacttcaatgccatc360atatcaaccagcaacatcccggcccctcctgtatca396<210>406<211>444<212>蛋白质<213>大鼠<400>406MetLeuValAlaPheLeuGlyAlaSerAlaValThrAlaSerThrGly151015LeuLeuTrpLysLysAlaHisAlaGluSerProProSerValAsnSer202530LysLysThrAspAlaGlyAspLysGlyLysSerLysAspThrArgGlu354045ValSerSerHisGluGlySerAlaAlaAspThrAlaAlaGluProTyr505560ProGluGluLysLysLysLysArgSerGlyPheArgAspArgLysVal65707580MetGluTyrGluAsnArgIleArgAlaTyrSerThrProAspLysIle859095PheArgTyrPheAlaThrLeuLysValIleAsnGluProGlyGluThr100105110GluValPheMetThrProGlnAspPheValArgSerIleThrProAsn115120125GluLysGlnProGluHisLeuGlyLeuAspGlnTyrIleIleLysArg130135140PheAspGlyLysLysIleAlaGlnGluArgGluLysPheAlaAspGlu145150155160GlySerIlePheTyrThrLeuGlyGluCysGlyLeuIleSerPheSer165170175AspTyrIlePheLeuThrThrValLeuSerThrProGlnArgAsnPhe180185190GluIleAlaPheLysMetPheAspLeuAsnGlyAspGlyGluValAsp195200205MetGluGluPheGluGlnValGlnSerIleIleArgSerGlnThrSer210215220MetGlyMetArgHisArgAspArgProThrThrGlyAsnThrLeuLys225230235240SerGlyLeuCysSerAlaLeuThrThrTyrPhePheGlyAlaAspLeu245250255LysGlyLysLeuThrIleLysAsnPheLeuGluPheGlnArgLysLeu260265270GlnHisAspValLeuLysLeuGluPheGluArgHisAspProValAsp275280285GlyArgIleSerGluArgGlnPheGlyGlyMetLeuLeuAlaTyrSer290295300GlyValGlnSerLysLysLeuThrAlaMetGlnArgGlnLeuLysLys305310315320HisPheLysAspGlyLysGlyLeuThrPheGlnGluValGluAsnPhe325330335PheThrPheLeuLysAsnIleAsnAspValAspThrAlaLeuSerPhe340345350TyrHisMetAlaGlyAlaSerLeuAspLysValThrMetGlnGlnVal355360365AlaArgThrValAlaLysValGluLeuSerAspHisValCysAspVal370375380ValPheAlaLeuPheAspCysAspGlyAsnGlyGluLeuSerAsnLys385390395400GluPheValSerIleMetLysGlnArgLeuMetArgGlyLeuGluLys405410415ProLysAspMetGlyPheThrArgLeuMetGlnAlaMetTrpLysCys420425430AlaGlnGluThrAlaTrpAspPheAlaLeuProLys435440<210>407<211>53<212>蛋白质<213>小鼠<400>407ArgArgThrLeuThrGlyGlnLeuGlyLeuPheSerValAspPheMet151015ValCysIlePheLeuPheLeuPhePheCysPheLeuPheProPhePro202530LeuPheLeuValArgLysHisIleLeuLeuSerHisCysLysGlnTrp354045GluGlySerThrMet50<210>408<211>119<212>蛋白质<213>大鼠<400>408GlyThrSerProAlaSerValLeuArgSerValSerSerAspProSer151015LeuProProProSerMetAlaSerLeuLeuCysCysGlyProLysLeu202530AlaAlaCysGlyIleValLeuSerAlaTrpGlyValIleMetLeuIle354045MetLeuGlyIlePhePheAsnValHisSerAlaValLeuIleGluAsp505560ValProPheThrGluLysAspPheGluAsnGlyProGlnAsnIleTyr65707580AsnLeuTyrGluGlnValSerTyrAsnCysPheIleAlaAlaGlyLeu859095TyrLeuLeuLeuGlyGlyPheSerPheCysGlnValArgLeuAsnLys100105110ArgLysGluTyrMetValArg115<210>409<211>590<212>蛋白质<213>小鼠<400>409LysValGluGlyGluGlyArgGlyArgTrpAlaLeuGlyLeuLeuArg151015ThrPheAspAlaGlyGluPheAlaGlyTrpGluLysValGlySerGly202530GlyPheGlyGlnValTyrLysValArgHisValHisTrpLysThrTrp354045LeuAlaIleLysCysSerProSerLeuHisValAspAspArgGluArg505560MetGluLeuLeuGluGluAlaLysLysMetGluMetAlaLysPheArg65707580TyrIleLeuProValTyrGlyIleCysGlnGluProValGlyLeuVal859095MetGluTyrMetGluThrGlySerLeuGluLysLeuLeuAlaSerGlu100105110ProLeuProTrpAspLeuArgPheArgIleValHisGluThrAlaVal115120125GlyMetAsnPheLeuHisCysMetSerProProLeuLeuHisLeuAsp130135140LeuLysProAlaAsnIleLeuLeuAspAlaHisTyrHisValLysIle145150155160SerAspPheGlyLeuAlaLysCysAsnGlyMetSerHisSerHisAsp165170175LeuSerMetAspGlyLeuPheGlyThrIleAlaTyrLeuProProGlu180185190ArgIleArgGluLysSerArgLeuPheAspThrLysHisAspValTyr195200205SerPheAlaIleValIleTrpGlyValLeuThrGlnLysLysProPhe210215220AlaAspGluLysAsnIleLeuHisIleMetMetLysValValLysGly225230235240HisArgProGluLeuProProIleCysArgProArgProArgAlaCys245250255AlaSerLeuIleGlyIleMetGlnArgCysTrpHisAlaAspProGln260265270ValArgProThrPheGlnGluIleThrSerGluThrGluAspLeuCys275280285GluLysProAspGluGluValLysAspLeuAlaHisGluProGlyGlu290295300LysSerSerLeuGluSerLysSerGluAlaArgProGluSerSerArg305310315320LeuLysArgAlaSerAlaProProPheAspAsnAspCysSerLeuSer325330335GluLeuLeuSerGlnLeuAspSerGlyIleSerGlnThrLeuGluGly340345350ProGluGluLeuSerArgSerSerSerGluCysLysLeuProSerSer355360365SerSerGlyLysArgLeuSerGlyValSerSerValAspSerAlaPhe370375380SerSerArgGlySerLeuSerLeuSerPheGluArgGluAlaSerThr385390395400GlyAspLeuGlyProThrAspIleGlnLysLysLysLeuValAspAla405410415IleIleSerGlyAspThrSerArgLeuMetLysIleLeuGlnProGln420425430AspValAspLeuValLeuAspSerSerAlaSerLeuLeuHisLeuAla435440445ValGluAlaGlyGlnGluGluCysValLysTrpLeuLeuLeuAsnAsn450455460AlaAsnProAsnLeuThrAsnArgLysGlySerThrProLeuHisMet465470475480AlaValGluArgLysGlyArgGlyIleValGluLeuLeuLeuAlaArg485490495LysThrSerValAsnAlaLysAspGluAspGlnTrpThrAlaLeuHis500505510PheAlaAlaGlnAsnGlyAspGluAlaSerThrArgLeuLeuLeuGlu515520525LysAsnAlaSerValAsnGluValAspPheGluGlyArgThrProMet530535540HisValAlaCysGlnHisGlyGlnGluAsnIleValArgThrLeuLeu545550555560ArgArgGlyValAspValGlyLeuGlnGlyLysAspAlaTrpLeuPro565570575LeuHisTyrAlaAlaTrpGlnGlyHisLeuProIleGlyLys580585590<210>410<211>339<212>DNA<213>人<400>410atggctttgggagttccaatatcagtctatcttttattcaacgcaatgacagcactgacc60gaagaggcagccgtgactgtaacacctccaatcacagcccagcaaggtaactggacagtt120aacaaaacagaagctgacaacatagaaggacccatagccttgaagttctcacacctttgc180ctggaagatcataacagttactgcatcaacggtgcttgtgcattccaccatgagctagag240aaagccatctgcaggtgttttactggttatactggagaaaggtgtctaaaattgaaatcg300ccttacaatgtctgttctggagaaagacgaccactgtga339<210>411<211>285<212>DNA<213>人<400>411atggctttgggagttccaatatcagtctatcttttattcaacgcaatgacagcactgacc60gaagaggcagccgtgactgtaacacctccaatcacagcccagcaagctgacaacatagaa120ggacccatagccttgaagttctcacacctttgcctggaagatcataacagttactgcatc180aacggtgcttgtgcattccaccatgagctagagaaagccatctgcaggtgtctaaaattg240aaatcgccttacaatgtctgttctggagaaagacgaccactgtga285<210>412<211>460<212>DNA<213>人<400>412aagagaaagaaagttaagcaactacaggaaatggctttgggagttccaatatcagtctat60cttttattcaacgctgacaacatagaaggacccatagccttgaagttctcacacctttgc120ctggaagatcataacagttactgcatcaacggtgcttgtgcattccaccatgagctagag180aaagccatctgcaggtgtctaaaattgaaatcgccttacaatgtctgttctggagaaaga240cgaccactgtgaggcctttgtgaagaattttcatcaaggcatctgtagagatcagtgagc300ccaaaattaaagttttcagatgaaacaacaaaacttgtcaagctgactagactcgaaaat360aatgaaagttgggatcacaatgaaatgagaagataaaattcagcgttggcctttagactt420tgccatccttaaggagtgatggaagccaagtgaacaagcc460<210>413<211>112<212>蛋白质<213>人<400>413MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnGlyAsnTrpThrValAsnLysThrGluAlaAspAsnIle354045GluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGluAspHis505560AsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuGlu65707580LysAlaIleCysArgCysPheThrGlyTyrThrGlyGluArgCysLeu859095LysLeuLysSerProTyrAsnValCysSerGlyGluArgArgProLeu100105110<210>414<211>94<212>蛋白质<213>人<400>414MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnAlaAspAsnIleGluGlyProIleAlaLeuLysPheSer354045HisLeuCysLeuGluAspHisAsnSerTyrCysIleAsnGlyAlaCys505560AlaPheHisHisGluLeuGluLysAlaIleCysArgCysLeuLysLeu65707580LysSerProTyrAsnValCysSerGlyGluArgArgProLeu8590<210>415<211>73<212>蛋白质<213>人<400>415MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaAsp151015AsnIleGluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGlu202530AspHisAsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGlu354045LeuGluLysAlaIleCysArgCysLeuLysLeuLysSerProTyrAsn505560ValCysSerGlyGluArgArgProLeu6570<210>416<211>312<212>DNA<213>人<400>416atggctttgggagttccaatatcagtctatcttttattcaacgcaatgacagcactgacc60gaagaggcagccgtgactgtaacacctccaatcacagcccagcaagctgacaacatagaa120ggacccatagccttgaagttctcacacctttgcctgggagatcataacagttactgcatc180aacggtgcttgtgcattccaccatgagctagagaaagccatctgcaggtgttttactggt240tatactggagaaaggtgtctaaaattgaaatcgccttacaatgtctgttctggagaaaga300cgaccactgtga312<210>417<211>103<212>蛋白质<213>人<400>417MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnAlaAspAsnIleGluGlyProIleAlaLeuLysPheSer354045HisLeuCysLeuGlyAspHisAsnSerTyrCysIleAsnGlyAlaCys505560AlaPheHisHisGluLeuGluLysAlaIleCysArgCysPheThrGly65707580TyrThrGlyGluArgCysLeuLysLeuLysSerProTyrAsnValCys859095SerGlyGluArgArgProLeu100<210>418<211>846<212>DNA<213>大鼠<400>418aggagagaaagagaagtgtgcacaaagaaacttgtattattattaattagcacctagctt60gtttgtgtctgatacaccaccaagtagtaattgttgaaaaaacgaagaagaaaaaaaaaa120aacaaaaaaaccaaacagtgggtactcaaataagataggagaaaaatgagagaacagacc180cagttctcgacccttgcttctcaaggtcctcccaccaggctgccaaagcaagatggtgtt240gctctgatccagtcagtattcttttgacttttttttttaatctccaggttttggttcagg300ctcccatattcataccctggctcatttagctttccctcatgttgtgggttcttctgtccc360tcacccccttactctccccactgatattcttcccagtcaagactgtggctctggaagaaa420tatccaccatttgcagagctgatgttctgtagatcgtaatgttgaagcgctgggtgtcct480ggttggcagaatcactcctgtattactctggtacataggtgtctcctgatagactccctg540gccttagtcatggggtgttttctagaggcagactaagacaggagtcaaaaaagatttaga600ggaaggagctgaggaaagaaagacagttgtgggaggaaaatcaagttctactcaggatcc660cgagtgtttctgtagatgtagattggaatgtgtccataacagagaggccagtgagagaca720tccccaaggacctgccaggctttccttcgctccaggaagacgcaccatcactcaaaaggg780gtttcctagaaagaaagacaagtgacttaaaaaatctgccagtgggttcttgaagtcatc840gaacct846<210>419<211>960<212>DNA<213>小鼠<400>419agagtatgaagccagagtcttagagaagtcactgagaaaagaatccagaaacaaagagac60cgacaaggtgaagctgacctggagggaccgattcccagcctatttcaccaatcttgtctc120catcatcttcatgatcgcagtgacatttgcaatcgtcctcggagttatcatctatagaat180ctccacagctgcagccttggccatgaactcctccccgtctgtgcggtccaacatccgggt240tacagtcacggccaccgctgttatcatcaacctcgtggtcatcattctgctggatgaagt300ttacggctgcattgccaggtggctcaccaagattggtgagtgccatgtgcaggacagcat360aggcagcatgggcctagggcagggccagccttgaagtgggcagcctggtcacagaactgt420ggctagtcccaacttcccctggcctggcctggctgtgagtggctagcagctggcacagtc480agtaccgtatgtctctcctcagaggtcccaaagacagagaagagctttgaggagaggcta540accttcaaggccttcctgctcaagtttgtgaactcttacactcccatcttctatgtcgcc600ttcttcaaaggccggtttgttggtcggcccggtgactacgtgtacatcttccgctctttc660cggatggaggagtgtgccccgggcggctgcctcatggagctctgtatccagctgagcatc720attatgctgggcaagcagctaatccagaacaatctcttcgagattggcatcccgaagatg780aaaaagttcatccgctacctgaagctgcgcagacagagcccctcagaccgtgaagagtac840gtgaagcggaagcagcgctatgaggtggacttcaacctcgaacctttcgccggcctcacg900cccgagtacatggaaatgatcattcagttcggctttgtcaccctgtttgttgcgtccttc960<210>420<211>1330<212>DNA<213>小鼠<400>420gcaacttggacactaaagctaggtaccagcctgttagtttacatgagttcaaaattcagg60tcagggtctctgaaatggagtctgaatttaaaagctttggcctctcatgtgaataataca120tatgtcatgtgtcatttgaatagtttcagtcacacacactttgtatttctctaagtgtaa180cgcatgtgtagtgggtggttgtagtatgatttctccgtctttcttgtttgaatgtttgga240cttgtgcacgtgtgcacatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatt300tgctcctgtggctatgtgcatgtgccatgtgggtgtgtgtgcttgtgggggccagaggtt360aggtaccttcctctatctctccaccctggtggtttttgttttgttttgttttgttttgga420ccaggtctatcactgataagctaggttggatggcttctgagaagagtctgcctctctgtc480cccctgcccctyctccccccagccctcaggttacagataagtgccacaagtccttgtcct540ttcaagtagcctctagggatccaggctcatatccttgtgcttactgactgagccacctct600cagctccctcagccccgttttacacgttaactttgtctcctgtctatgcctgctctcttc660agtgaccccttccgttttcctttcactcttttctctgaatagatttgtgtgcgagagact720attatcatatggatgcataaatatcatctgcaaagtcaatcgcaggaaagacttagagtc780tctttagctttatgactgtaaaggattccgcttcttgccattgattcagcttttttgcca840ttgatcctttattagagatcaattagagtcgtatacaaagaccttggctgggccctgagg900gtctatctcaggctaggccctgagggtctatctcaggctaggccctgagggtctatctca960ggatagatggatttaactgcttttctcaagacgcttttactctctcgttgaattcttttt1020aaacttttaattgacattgtacttgcattcttatgggaaacagggtgacccacacacatg1080tgtacacaggtacacacacagtcaggtcagcatagctggtatgttgttgtttatgttggg1140gacagtcagattggtattgtttttgcactgtgctgtggaacattggaaaaccttatctga1200tggtgaccctgtgcctactaacagccctcactaggatacattttggagtctctggcaacc1260acaattttgctctatttccatgagtccagcatctctactactgcatagaagtaaaaaaaa1320aaaaaaaaaa1330<210>421<211>880<212>DNA<213>小鼠<400>421aggaccttgaccgacatccagaccacgggacccgactggatgtctcaccctgcccctgca60ggccctgtcccttccaaaacaggcacttctgtcacaggatacttttttttttaacttaaa120tttgcttgggggaggggagcagttctagttccatgaggcacaaatggaggtcaaagagca180acttgccgatgtctcttctctcctcccactgtgtgggtagtaggaattgaatcaggttat240cgatcttggggctgagccatctctgtggcccacagagcacttatatgtggttacttgttg300ctctcacattgtcagtgtacagcttggtggcctttgtcactggcatgctctgtgacactg360ttgtgataaaaatgttgatgagtttacacaaatctagtaaattgaacccaagagccaagt420gtggtggtgtacccttaattccagcactttgggggcaagttcaggtagttctctgaattt480gagagcctcctggcccacatagtgagttccatggctgcgtagttgcaaaagaacaccaac540acctttcccccacaaatagaattgtactgaaggtcacagtcagagaaagcatagcaagga600tggctgctctgagcccctcctgtgcacttctgtagacctagccccggtgtctaaatggag660tctgattttagcacctgcacttgactgctgtgctccaccctgacccgccttytcctgatc720ccagattgctagaactttgaccaaaatgggacttaattggagttgtgattggkatgttca780ttgatttaaagtgctctttacattttaaggaaactaaccctttgggtaagaaaaaaaaaa840aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa880<210>422<211>533<212>DNA<213>小鼠<400>422cctaaatgctgggattaaaggcgtgcgccactactgccaggctgtttttttttttttttt60ttttttattaatgatctgccagacaaagagatgtcctttttggtgcaaaagtcacccaat120gcttgaagtcactatatttgattagctctgtaactgatacacaaataaaactttccatta180tggataatacattatctattattatttatctcttgttcatttttgcaatttctgtacttg240actcccagttgagtacaaggtgcctttggtggttttccaaggatcttgaggttacatgaa300attgctgatgatgtctgttgaaagcattgtatggaggcctgaggtatatttggcctgaga360gcagagtttttaaaatagagcctgctggaaaagctagctggagcttctgactactttaga420aaggcactgtttgaagcacaggccatgaagtaagacttgctttctagttaaattgaggtt480ttttgtttttttaagtcwttagtgtatagagatttcctacattttttgtggtt533<210>423<211>738<212>DNA<213>大鼠<400>423ataaggcacatttgcttcataaaataaaaaaaaaggaaatttacttagccgcatgtcagt60cacccaaattttgagtgtacaaatgaaatggaaaacatttattacacaaatttaattaca120attctagggaataaacatgcaaatcagatggagctcaatctgcaggcgctgatcctctcc180ccctggtttgcagtctgtgcacctcctggattcgcccgcgaccaggcagtcagaggcctg240gctcttgcaggcaggaggatcactgttgtaaagaacagcgtcacatttagcgcatctggc300gtagtagcagtttttaacactttgcgcaggtgcctcccttcccccacccgcgctttgtta360ggtctacctctctaaatctctgccttcctcgcacagtaagtgacctctccatgacaaagg420gcccccagacagcagttataaatcaatgtgttttgggtttgtttgtttgtttgttttgtt480ttaaagaaaaacccggccatgcttggtggcacttgcctttaatagtagcgcttggtagac540agaggcaagcggttctctgtaagttcaaggccagcctggtctacacagtgagaccgggtc600tcaaaaacaaaacaacaaaaaacaactcctattgaatccactacaggaagggggggcgcg660gatcactgtctgcaaactaaagtgacttgagctcctgtcacagcctttccagcaagggca720agcttctttattagttat738<210>424<211>1035<212>DNA<213>大鼠<400>424cctgaggcgactacggtgcgggtgccgggtgccgggtgcctacagcccccatcagcttcc60ccggggagattctgccgatttgtcacgagccatgctcaggaggcagctcgtctggtggca120cctgctggctttgcttttcctcccattttgcctgtgtcaagatgaatacatggagtctcc180acaagctggaggactgcccccagactgcagcaagtgttgccatggagattatggattccg240tggttaccaagggccccctggacccccaggtcctcctggcattccaggaaaccatggaaa300caatggaaataacggagccactggccacgaaggggccaagggtgagaaaggagacaaagg360cgacctggggcctcgaggggaacgggggcagcatggccccaaaggatagaagggataccc420aggggtgccaccagagctgcagattgcgttcatggcttctctagcgactcacttcagcaa480tcagaacagtggcattatcttcagcagtgttgagaccaacattggaaacttcttcgatgt540catgactggtagatttggggcccccgtatcaggcgtgtatttcttcaccttcagcatgat600gaagcatgaggacgtggaggaagtgtatgtgtaccttatgcacaatggtaacacggtgtt660cagcatgtacagctatgaaacaaagggaaaatcagatacatccagcaaccatgcagtgct720gaagttggccaaaggagatgaagtctggctaagaatgggcaacggtgccctccatgggga780ccaccagcgcttctctaccttcgcaggctttctgctttttgaaactaagtgatgaggaag840tcaggatagctccatgctaagggcgatttgtaggtgagctagggttgttaggatctgagg900ggtgttggagttgggcttctctatggagtatttaactgttacattggtcacactgctact960cattctaatggcataccaattatgttggatactttaggggctaggaagaatagaccacaa1020ggtaatattcccaga1035<210>425<211>835<212>DNA<213>大鼠<400>425gtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaagttattctcctggt60tcactggctgttgacaacctggggctgcttggcgttctcaggctcctatgcttggggcaa120cttcactatcctggccctgggtgctgtgggctgtggcccagcgggactctgttgatgcca180ttggcatgtttcttggtggcttggttgccaccatcttcctggacattatctacattagca240tcttctactcaagcgttgccgttggggacactggccgcttcagtgccggcatggccatct300tcagcttgctgctgcaagcccttctcctgctgcctcgtctaccacatgcaccgggcagcg360agggggtgagctcccgctccgctcggatttcttcggaccttctcaggaacatagtgccta420ccagacaattgactcgtcagactcacctgcagacccccttgcaagcctggagaacaaggg480ccaagctgccccccgggggtactgaagctgtccctggccgtcctggggcccagcaggatg540cttgtcaccttctttactggacctacaatggggtatcctccattccctgccacagaggtg600gcctgagtcatgtgccctcggaggtcccagctgagaagagcccagtcctaattctccatg660ctgcccctccattcaagacacctgttaacccctgggctagaactgtggttggtttcttcc720cctcctccccatcactataacacacaaccgccgagctgtgcagagtgttcagggccatcc780aggccttatgggccaatgatcactgcctctcaggctaccccaaggtgacccagcc835<210>426<211>1337<212>DNA<213>小鼠<220><221>不确定<222>(626)...(626)<400>426accggcctcactatgtctgccattttcaattttcagagtctgttgactgtaatcttgctg60cttatatgtacatgtgcttatatccgatccctggcacccagcatcctggacagaaataaa120actggactattgggaatattttggaagtgtgcccgaattggggaacgcaagagtccttat180gtcgccatatgctgtatagtgatggccttcagcatcctcttcatacagtagctttggaaa240ctaccagcatgtgcttgctatcagactgtaaacaaggacttgcctccagaaaataatggg300aagaatggttaagccatttgtctctgaacatggaatgagataaacttcaagatgctgttc360tctatttttatgctattggaccaatgagctgaatgaataattaagatgtaacagttcaat420acacaggaatgtgattgtatccatcaacctcagttctctcactccagtattacattctgc480aaatgtcattctgttgtgtcaggactgcttttcataaggttcttcgggcacgaagtagaa540acccagtggcaaattccaaggctcctttgactagggcttcaaaataatgtcttcacagaa600tggtacctctagcgactgtcctattnttattgagaaaaaaacttgttctatttttgttgt660tgttactgttcttatggattgcattcatatttaaaccctttggattgctaaccagagtac720ctctattcttggcaaattccgcagtttattacaggtgtttaaagtattttaaacaaaact780ctgaatttctttagttagcctaagagttggcttctagtcacaaagatacagctgccacac840tgtgacgaagagcaccttagaaagaaaagcagcaagtgagcggtgagcaagtaagcaccg900tgcagtcttcgtgcaagtaagcaccgtgcagtcttcgttctctgtagtcttgtcttccaa960atagaacgtccatcgtagttacccaaaggtggtatttgtggtgttcttaatgcagtgctt1020taagtctagtgtatgttctgtcagcttgaactggaatctctcttgtaactttgtaggtta1080taaacatatctcatatctgctttagtctgggtactatgctctaagtacatttcagctttg1140acacagaatgtgaatagacgaatatcaaaggatacttacaagtttgtatccaacatttct1200tcaggttcagctgaaaatcagttactgtttcaaaacaaagaggaattaaatcctagctga1260aaactatacatagcatttattaattaattactgggtttaactgctctttttaaaagtttg1320aaaaaaaaaaaaaaaaa1337<210>427<211>780<212>DNA<213>小鼠<400>427gctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttgcgggctcg60cgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatctggtgggga120acacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaagtcaggag180gaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtggatcaactc240atggagctggccgggttgagctgtgccacggctattgccaaggcttatccccccacgtct300atgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacggaggggat360gggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatctattacccc420aaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaatggacatt480cctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccctagcggaa540tccaaccagacttactcatctcactgacggcacccaagaagtctgcaactcactttactg600gccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaagtaccagc660tgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagggaggtggg720taggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaaaaaaaaaaaa780<210>428<211>460<212>DNA<213>小鼠<400>428aatcatggcgccgtcgctgtggaaggggcttgtaggtgtcgggctttttgccctagccca60cgctgccttttcagctgcgcagcatcgttcttatatgcgactaacagaaaaggaagatga120atcattaccaatagatatagttcttcagacacttctggcctttgcagttacctgttatgg180catagttcatatcgcaggggagttcaaagacatggatgccacttcagaattaaagaataa240gacatttgataccttaaggaatcacccatctttttatgtgtttaaccatcgtggtcgagt300gctgttccggccttcagatgcaacaaattcttcaaacctagatgcattgtcctctaatac360atcgttgaagttacgaaagtttgactcactgcgccgttaagctttttacaaattaaataa420caggacagacacagaattgagtattggagtttggggtgta460<210>429<211>472<212>DNA<213>小鼠<400>429gaagcctcttcccatggaagcacactctaggagagagaaggcctctgggctccgcctggc60ctggcattatgaatgcagtggggtcagtgtgtggtggatgtgtgtactgggttggctttc120ctttttagtttttttactttttagtttagtttgttcttttccttccccaataaatcattc180tcacatgcttccatgtttgtttctgagaggtgggggctcaaatgtatagaaagtaggccc240cagtccataaggaggtgtgaacacacccccttactgcttatcacccatttgacaggaacg300cccaggaggggagggggaggggaagaggtgagttctgcacagtcggacatttctgttgct360tttgcatgtttaatatagacgttcctgtcgatccttgggagatcatggccttcagatatg420cacacgacctttgaattgtgcctactaattatagcaggggacttgggtaccc472<210>430<211>954<212>DNA<213>小鼠<400>430attagcggctcctcagcccagcaaatcctccactcatcatgcttcctcctgccattcatc60tctctctcattcccctgctctgcatcctgatgagaaactgtttggcttttaaaaatgatg120ccacagaaatcctttattcacatgtggttaaacctgtcccggcacaccccagcagcaaca180gcaccctgaatcaagccaggaatggaggcaggcatttcagtagcactggactggatcgaa240acagtcgagttcaagtgggctgcagggaactgcggtccaccaaatacatttcggacggcc300agtgcaccagcatcagccctctgaaggagctggtgtgcgcgggcgagtgcttgcccctgc360cggtgcttcccaactggatcggaggaggctacggaacaaagtactggagccggaggagct420ctcaggagtggcggtgtgtcaacgacaagacgcgcacccagaggatccagctgcagtgtc480aggacggcagcacgcgcacctacaaaatcaccgtggtcacggcgtgcaagtgcaagaggt540acacccgtcagcacaacgagtccagccacaactttgaaagcgtgtcgccagccaagcccg600cccagcaccacagagagcggaagagagccagcaaatccagcaagcacagtctgagctaga660cctggactgactaggaagcatctgctacccagatttgattgcttggaagactctctctcg720agcctgccattgctctttcctcacttgaaagtatatgctttctgctttgatcaagcccag780caggctgtccttctctgggactagcttttcctttgcaagtgtctcaagatgtaatgagtg840gtttgcagtgaaagccaggcatcctgtagtttccatcccctcccccatcccagtcatttc900tttaaaagcacctgatgctgcattctgttacagtttaaaaaaaaaaaaaaaaaa954<210>431<211>780<212>DNA<213>小鼠<400>431gctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttgcgggctcg60cgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatctggtgggga120acacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaagtcaggag180gaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtggatcaactc240atggagctggccgggttgagctgtgccacggctattgccaaggcttatccccccacgtct300atgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacggaggggat360gggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatctattacccc420aaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaatggacatt480cctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccctagcggaa540tccaaccagacttactcatctcactgacggcacccaagaagtctgcaactcactttactg600gccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaagtaccagc660tgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagggaggtggg720taggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaaaaaaaaaaaa780<210>432<211>1144<212>DNA<213>小鼠<400>432cttctcagggcctgccacccaaataagtctggccctagcctcaactctctctcaggctgg60gccacaggaagctgctgactggccacttgacaccctccccctaaagctaatgtctgtgac120tatagggaggttagcactttttctaattggaattcttctctgtcctgtggccccatccct180cacccgctcttggcctggaccagatacatgcagcctctttctccagcacagcctttccct240gagcctgaggttagggcagagtttagagggtgggctaagtgtatgttttcatgtatgcat300tcatgcctgtgagtgtgtggcttgctgtcgtgtcctctgggatcccaagccacgcgggtc360ttccctctgtagatgggtcctgggttctatcacctgcttatttatgtacgaggttggggg420gtggacccagggtgggttgattgtctctttgtaaggaagtatgtgtcgggggtgacacga480ggctaagcccgagaaaccccgggagacagcactgcataagaaactggtttccmagactgc540agagggagctgcacttttgttttgaccaaaaacaaaaaacaaaacaaaacaaaaacaaaa600caaaaataactctgaagggcgggaggatacccaagcctgatgcctgagaggagtccctag660acttcagcaactccgctgcgtggcctgagcccagcgggagggatggggagagaatttttt720ggagtccgtgcctgtggtgggcagtcctgagccttcagctgaagcagtgctttttggctg780ccctcacctcgcactacttgaccttgaggctctgagtatctcctgtgcacaggagaagct840cctgcaccagaaagcaccaaarsccmtggcaccccatcttactccactctccccagggac900tcccaggtgggaactgctgtggcagtgagctcagcccggacagacactgccaaccctgtc960tcctggcattgggctccggctctacctccccaagcagggcgaggccccgccttctcagcc1020tagcaccacctgtccccgagtcttctcagcttgcccatcattctcggcgcccacacaggt1080gacagtcccaagtagataacctccatgggacaagttgggtgttgccttacccgcctgccc1140agcc1144<210>433<211>438<212>DNA<213>小鼠<400>433cttgagtctggagtgctgcaaataatagtatgcactatccctgcctggcatgtttgtttg60ttaatgtgcactggtgttttgcctggatgtgtatacttgtgaagatgtcagaactcctgg120agctggagttagagacaatggtgagctgccttgtggatgttgggaattgaacccaggtcc180tctggagaaataaccagtgctcttaaccactaagccatctcaacagccccaaattatttt240tttaataagttgcctcggtcatgttgtcttaatcagagcgatagaaaagtaactaatata300gattatttatgaattcaggtggcttaatggtatatgcatgaattagtagtaaaacaagaa360ctagggccagcaagtggcttaagggtgcctgctaaccatctcagccacctgagttcagtc420tccaggaaccacacagtg438<210>434<211>383<212>DNA<213>小鼠<400>434cccacgtctatgttcaccttcgttgttctggtaatcaccatcgtcatctgtctctgccac60gtctgctttggacacttcaaatacctcagtgcccacaactacaagattgaacacacagag120acagatgccgtgagctccagaagtaatggacggccccccactgctggcgctgtccccaaa180tctgcgaaatacatcgctcaggtgctgcaggactcagagggggacggggacggagatggg240gctcctgggagctcaggcgatgagcccccatcgtcctcctcccaagacgaggagttgctg300atgcctcctgatggcctcacggacacagacttccagtcatgcgaggacagcctcatagag360aatgagattcaccagtaaggggt383<210>435<211>405<212>DNA<213>大鼠<220><221>不确定<222>(114)...(114)<221>不确定<222>(346)...(346)<221>不确定<222>(353)...(353)<221>不确定<222>(387)...(388)<400>435ctcgtgccgaattcggcacgagtggcgagatggggatgcgccctggagccgactgggctg60cggtctgcgctttgtggccttcctggcgaccgagctgctccctcccttccagcnggcgaa120ttcagcccgacgagctgtggctttaccggaacccgtacgtgaaggcggaatacttcccca180ccggccccatgtttgtcattgcctttctcaccccactgtccctgatcttcttcgccaagt240ttctgaggaaagctgacgccgaccgacagcgagcaagcctgcctcgctgccagccttgcc300ctagcgctaaatggtgtctttaccaacatcataagactgatagtgngcaaggncacgccc360aaattgcttctaccgagtgttccccgnncgggattgcccattctt405<210>436<211>151<212>DNA<213>大鼠<400>436atactgcctgtagagttagtatttctgttttatatatgttgcacactgaattgaagaaat60gttggtttttcttgttttgttttagtttgtttctttggttttgtttttggttttgctttt120tacttcccaggtttgactatttgccaatgcc151<210>437<211>1715<212>DNA<213>小鼠<400>437cagaatatggctctgggggttctgatagcagtctgcctcttgttcaaagcaatgaaggca60gcactgagcgaagaagcagaggtgatccctcctagcacagcacagcagagcaactggaca120tttaacaacaccgaagctgactacatagaagaacctgtagctctgaagttctctcatcct180tgtctggaagaccataatagttactgcattaatggagcatgtgcattccaccatgagctg240aagcaagccatttgcagatgctttactggttatacgggacaacgatgtgagcatttgacc300ctaacttcgtatgctgtggattcttatgaaaaatacattgcgattgggattggcgtcgga360ttgctaattagtgcttttcttgctgtcttctattgctacataagaaaaaggtgtataaat420ctgaaatcaccctacatcatctgctctggagggagcccattgtgagaccttataagacat480agtcatcaagccatttgtcaaaagccacagggaatccaatggagatctttggatgataca540aaatgtgataagctaacttgaaaataatggtggtttgggtcacaatgcagtaactgacca600ttggttcttagctttggtcatcgttgggtgccatggaagctatgggaatgagctacagta660acagaagccaagttcactacccttctttgggtttgctgttgggtggttgttgtcactgca720ggaagatttgttctatacttctgaccatctcagatgtgaattttcattttaattgttttc780tactacacatcaatcaagtccaagtaatgccatttccgggttcttcgggcactcaacatt840ttgggccacccgcctcgatggacctaatagcaaagtatctgtccttatggaatttcaggg900aatttggtatcaatttttagatgaaaacagtgaatgtctcagctccttgagtgaaccaaa960gatgcattacacctaaaccactaaaagaaaatggaatatccaaggcagcataaatcctac1020ccagctggtgacaacagtttgcaaacttcattcatgtagtttggaagaagcagataaatt1080cctgaggactgaaagtcacctggacagcagatccagagcaggcaaaggtagctggttcct1140atatcgaccataaagcctgtgtgggctcatctgtcccctgatgtttttgcctatcatctc1200agccttacattggaagactcacacttggtatccatcgcttgaactgaagttcgacaattc1260acctaatgactaaaagcttacaattgttcccaaaatatataggaacaacagcatgtggaa1320tgtaaccattttttgacgtgttgatagcatatttgcacatgggttaaaaaaagaaacagt1380cgtagaaatacttattagggaatcagtatccctccttggaattgcttctgctacatgatt1440caatcttgggcaagtctcttatattctttgtggtttggttccattctctacaagacccat1500gcagttccaaaattgaactctaatagaactaaaaaatacctcctataactgcatggcagg1560caagattatcctcaatgcttccatcctcagccccgtttctaaccctcaaatacccacgaa1620tattatccttactatatattgtcatgttcagtttgtaaaataataacttattttgaaaag1680aaataaaaaatgaaattacaaagcaaaaaaaaaaa1715<210>438<211>1627<212>DNA<213>小鼠<400>438cgggagcctgctactgccctgctgggttccttggggccgactgtagccttgcctgtccac60agggtcgcttcggccccagctgtgcccacgtgtgtacatgcgggcaaggggcggcatgtg120acccagtgtcggggacttgcatctgtcctcccgggaagacgggaggccattgtgagcgcg180gctgtccccaggaccggtttggcaagggctgtgaacacaagtgtgcctgcaggaatgggg240gcctgtgtcatgctaccaatggcagctgctcctgccccctgggctggatggggccacact300gtgagcacgcctgccctgctgggcgctatggtgctgcctgcctcctggagtgttcctgtc360agaacaatggcagctgtgagcccacctccggcgcttgcctctgtggccctggcttctatg420gtcaagcttgtgaagacacctgccctgccggcttccatggatctggttgccagagagttt480gcgagtgtcaacagggcgctccctgtgaccctgtcagtggccggtgcctctgccctgctg540gcttccgtggccagttctgcgagagggggtgcaagccaggcttttttggagatggctgcc600tgcagcagtgtaactgccccacgggtgtgccctgtgatcccatcagcggcctctgccttt660gcccaccagggcgcgcaggaaccacatgtgacctagattgcagaagaggccgctttgggc720cgggctgtgccctgcgctgtgattgtgggggtggggctgactgcgaccccatcagtgggc780agtgccactgtgtggacagctacacgggacccacttgccgggaagtgcccacacagctgt840cctctatcagaccagcaccccagcactccagcagcaaggccatgaagcactaactcagag900gaacgcccacagaggcccactactgtgttccagcccaagggacccaggcctctgctggtg960actaagatagaggtggcacttttggatccacacctcttctggaaagccatggattgctgt1020ggacagctatggatagtcatatagccacacacccgggctccatggtcatggggaagaagg1080cctcctttggacacaaggaatccaggaagtcggctgggcttcgggccactgtttacatgg1140ggaccctgcaggctgtgctgtggaatcctggccctcttcagcgacctgggatgggaccaa1200ggtgggaatagacaaggccccacctgcctgccaggtccttctggtgctaggccatggact1260gctgcagccagccaactgtttacctggaaatgtagtccagaccatatttatataaggtat1320ttatgggcatctccacctgccgttatggtcctgggtcagatggaagctgcctgaccccag1380aacttaggcagtggcctgtggggt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cccatgaatgacaagaac600gtgtacgctctggggaagaatctactgctacaagctcggtggttccacatcttgggaatg660atgatgttcttctggtcctctgcccatcagtataagtgccacgtcattctcagcaatctc720aggagaaataagaaaggtgtggtcatccactgccagcacagaatcccctttggagactgg780ttcgagtatgtgtcttctgctaactacctagcagagctgatgatctacatctccatggct840gtcaccttcgggctccacaacgtaacctggtggctggtggtgacctatgtcttcttcagc900caagccttgtctgcgttcttcaaccacaggttctacaaaagcacatttgtgtcctaccca960aagcataggaaagctttcctcccgttcttgttttgaacaggctttatggtgaagagcgca1020gcccaggtgacaggttcccttcctcgagacgctgagacaggctgaagtacactttctgca1080gctggcgcccgccaggctgctaccgagctgcgcgctcttccaggacctcatccgctacgg1140gaagaccaagcagtccggctcgcggcgccccgccgtctgcagcccgggggatccactagt1200tctagagcgccgcc1214<210>442<211>1977<212>DNA<213>大鼠<400>442aaaataaccaaccaaacaaactttcctcttcccgctagaaaaaacaaattctttaaggat60ggagctgctctactggtgtttgctgtgcctcctgttaccactcacctccaggacccagaa120gctgcccaccagagatgaggaactttttcagatgcagatccgggataaggcattgtttca180cgattcatccgtgattccagatggagctgaaatcagcagttacctatttagagatacacc240tagaaggtatttcttcatggttgaggaagataacaccccactgtcagtcacagtgacacc300ttgtgatgcgcctttggaatggaagcttagcctccaggagctgcctgaggagtccagtgc360agatgggtcaggtgacccagaaccacttgaccagcagaagcagcagatgactgatgtgga420gggcacagaactgttctcctacaagggcaatgatgtagagtattttctgtcttcaagttc480cccatctggtttgtatcagttggagcttctttcaacagagaaagacacacatttcaaagt540atatgccaccaccactccagaatctgatcaaccataccctgacttaccatatgaccccag600agttgatgtgacctctattggacgtaccacagtcactttggcctggaagcaaagccccac660agcttctatgctgaaacaacccatagagtactgtgtggtcatcaacaaggagcacaattt720caaaagcctttgtgcagcagaaacaaaaatgagtgcagatgatgccttcatggtggcgcc780caaacctggcctagactttagcccctttgactttgcccatttcggatttccaacagataa840tttgggtaaggatcgcagcttcctggcaaagccttctcccaaagtggggcgccatgtcta900ctggaggcctaaggttgacataaaaaaaatctgcataggaagtaaaaatattttcacagt960ctccgacctgaagcccaatacccagtactactttgatgtcttcatggtcaataccaacac1020taacatgaacacagcttttgtgggtgcctttgccaggaccaaggaggaggcaaaacagaa1080gacagtggagctcaaagatgggagggtcacagatgtggtcgttaaaaggaaagggaaaaa1140gtttctacggtttgctccagtctcctctcaccaaaaagtcaccctctttattcactcttg1200tatggacactgttcaagtccaagtgagaagagatgggaagctgcttctgtcacagaatgt1260ggaaggcattcggcagttccagttaagaggaaaacccaaaggaaagtacctcattcgact1320gaaaggcaacaagaaaggagcatcaatgttgaaaatactagccaccaccaggcccagtaa1380gcacgcattcccctctcttcctgatgacacaagaatcaaagcctttgacaagctacgcac1440ttgctcttcagtcacggtggcttggcttggcacccaagagaggagaaagttttgtatcta1500cagaaaggaagtgggtggaaactacagtgaagagcagaagagaagagagagaaaccagtg1560cctaggaccagacaccagaaagaagtcagagaaggttctttgcaagtacttccacagcca1620aaacctgcagaaagcagtgacgacagagacaatcagagatctgcaacctggcaagtctta1680cctactggacgtttatgttgtaggacatgggggacactctgtgaagtatcagagtaaact1740tgtgaaaacaaggaaggtctgttagttaccttaagtgaagatcagtagaactcccggaga1800gatatggaatcacactgcctgttactgactactctcatgacaaacagaagttgtacttga1860aagaaaggataacaacatgtgtacattgatgcctgtgtaatgtaacgtggagacttgtat1920tcacgcacacctgtggtacttagggtccatctgtctaatgctggctaatgtcaaagg1977<210>443<211>1744<212>DNA<213>大鼠<400>443ctgacatgaagccccctagacccagagattggttcctgctgtgacatgcctaccatgtgg60ccacttcttcatgtcctctggcttgctctggtctgtggctctgttcacaccaccctgtca120aagtcagatgccaaaaaagctgcctcaaagacgctgctggaaaagactcagttttcggat180aaacctgtccaagaccggggtctggtggtgacggacatcaaagctgaggatgtggttctt240gaacatcgtagctactgctcagcaagggctcgggagagaaactttgctggagaggtccta300ggctatgtcactccatggaacagccatggctatgatgttgccaaggtctttgggagcaag360ttcacacagatctcaccagtctggttgcagctgaagagacgtggtcgggagatgtttgaa420atcacaggcctccatgatgtggaccaagggtggatgcgagctgtcaagaagcatgccaaa480ggcgtgcgcatagtgcctcggcttctgtttgaagactggacttacgatgatttccgaagc540gtcctagacagtgaggatgagatagaagagctcagcaagactgtggtacaggtggcaaag600aaccagcattttgacggctttgtggtggaggtctggagccagttgctgagccagaaacat660gtaggcctcattcacatgcttactcacttggctgaggcgctgcaccaggccaggctgctg720gtcattctggtcatcccacctgctgtcacccctgggactgaccagctgggcatgtttaca780cacaaggagtttgagcagctggcccccatactagatggcttcagcctcatgacatacgac840tactccacatcacagcagcctggccctaatgctccattgtcatggatccgagcctgtgtt900caggtcctagaccccaagtcacagtggcgtagcaagatcctcctgggattgaacttctat960ggcatggattatgcagcctccaaggatgcccgtgagcctgtcattggagccagggcagtt1020ttgaaggtggctctgccattggctgtctcatcccagcagatctggacattgggaagagga1080gggtccaccagtgccctactcctggcaggcttggggctggcctcagagccctgtacaaag1140agcgaggaggttccaaagaagagcctcttagatacagtttggcactggcagggagagcca1200ggagcactgtgtagaggtcgtcttcacacctggatcctagtgagcgcggtcccgcaggcc1260tgcacatgcctgtttcagtgatggcctcacgaggcagcaccggctctagctgcactgctt1320tctttgattagctttggccatgggagacacaggtagcagcatagcgggtcaggaacctct1380tgagcagatccaaccaaaggctttttgtcacttgccagctctgcatggtcagcctgtgac1440accgtctcactcaaggccttctggagttggccctcagctcagatgtcatgtgagggatac1500cctaaggagatgatggggctccctcttgcctgagcttgcaggattggatcttgggcagat1560cagggcagtggaaacgtcagaccttctacccgtacatacagacgctgaaggaccacaggc1620cccgtgtggtatgggacagccaggctgcggaacacttctttgagtacaagaagaatcgcg1680gcgggaggcacgttgtcttctacccaacgctgaagtctctgcaggtgcggctggagctag1740ccag1744<210>444<211>2157<212>DNA<213>小鼠<400>444cctgctgccctcttgcagacaggaaagacatggtctctgcgcccggatcctacagaagct60catggggagccccagactggcagccttgctcctgtctctcccgctactgctcatcggcct120cgctgtgtctgctcgggttgcctgcccctgcctgcggagttggaccagccactgtctcct180ggcctaccgtgtggataaacgttttgctggccttcagtggggctggttccctctcttggt240gaggaaatctaaaagtcctcctaaatttgaagactattggaggcacaggacaccagcatc300cttccagaggaagctgctaggcagcccttccctgtctgaggaaagccatcgaatttccat360cccctcctcagccatctcccacagaggccaacgcaccaaaagggcccagccttcagctgc420agaaggaagagaacatctccctgaagcagggtcacaaaagtgtggaggacctgaattctc480ctttgatttgctgcccgaggtgcaggctgttcgggtgactattcctgcaggccccaaggc540cagtgtgcgcctttgttatcagtgggcactggaatgtgaagacttgagtagcccttttga600tacccagaaaattgtgtctggaggccacactgtagacctgccttatgaattccttctgcc660ctgcatgtgcatagaggcctcctacctgcaagaggacactgtgaggcgcaaaaagtgtcc720cttccagagctggcctgaagcttatggctcagacttctggcagtcaatacgcttcactga780ctacagccagcacaatcagatggtcatggctctgacactccgctgcccactgaaactgga840ggcctccctctgctggaggcaggacccactcacaccctgcgaaacccttcccaacgccac900agcacaggagtcagaaggatggtatatcctggagaatgtggacttgcacccccagctctg960ctttaagttctcatttgaaaacagcagccacgttgaatgtccccaccagagtggctctct1020cccatcctggactgtgagcatggatacccaggcccagcagctgacgcttcacttttcttc1080gaggacatatgccaccttcagtgctgcctggagtgacccaggtttggggccggatacccc1140catgcctcctgtgtacagcatcagccagacccagggctcagtcccagtgacgctagacct1200catcatccccttcctgaggcaggagaattgcatcctggtgtggaggtcagatgtccattt1260tgcctggaagcacgtcttgtgtcctgatgacgccccttaccctactcagctgttgctccg1320gtccctaggctccggtcgaacaaggccagttttactcctacatgcagcggactcagaggc1380acagcgacgcctggtgggagctttggccgaactgctgcggacggcgctgggaggtggacg1440cgacgtgatcgtggatctctgggaagggacgcacgtagcacgcattggaccactgccgtg1500gctttgggcagcgcgggagcgcgtggcgcgggagcagggcacagtgctgctcctgtggaa1560ctgtgcgggtcccagcaccgcctgcagcggtgacccgcaggctgcgtcccttcgcacctt1620gttgtgcgctgctccacgtccgctgctgctcgcctacttcagtcgcctctgcgccaaagg1680tgacatcccccggccgctgcgcgctctgccacgctaccgcctgcttcgtgacctgccgcg1740cctgctgagagcactggatgctcagcctgccaccctagcctccagctggagtcaccttgg1800ggctaagcggtgcttgaaaaaccgtctggagcagtgtcacctgctggaacttgaggctgc1860caaagatgactaccaaggctcaaccaatagtccctgtggtttcagctgtctgtagcctca1920gcctgtgtagcaacagcaggaactccagaatgaggcctcacacatgtactctttgggggt1980gcttcttgtcccccaaaccgtaagactcaccttaagtcccacacttgaccaacctccctc2040acatttgctccctcttagagttcctgagaggaacttgggctttcctgataggtcctcagc2100cctttctgagaaggagggacgatttttccatttcttttcaaaactgaaaaaaaaaaa2157<210>445<211>2250<212>DNA<213>小鼠<220><221>不确定<222>(2219)...(2219)<400>445aaaagagactccacccactccagtagaccggggactaaaacagaaattctgagaaagcag60caagaagcagaagaaatagctatttcacagcagtaacagaagctacctgctataataaag120acctcaacactgctgaccatgatcagcccagcctggagcctcttcctcatcgggactaaa180attgggctgttcttccaagtggcacctctgtcagttgtggctaaatcctgtccatctgta240tgtcgctgtgacgcaggcttcatttactgtaacgatcgctctctgacatccattccagtg300ggaattccggaggatgctacaacactctaccttcagaacaaccaaataaacaatgttggg360attccttccgatttgaagaacttgctgaaagtacaaagaatatacctataccacaacagt420ttagatgaattccctaccaaccttccaaagtatgtcaaagagttacatttgcaagagaat480aacataaggactatcacctatgattcactttcgaaaattccgtatctggaagagttacac540ttggatgataactcagtctcggctgttagcatcgaagagggagcatttcgagacagtaac600tatctgcggctgctttttctgtcccgtaaccaccttagcacaatcccggggggcttgccc660aggactattgaggaattacgcctggatgacaatcgcatatcaacgatctcttccccatca720cttcatggtctcacaagcctgaaacgcctggttttagatggaaacttgttgaacaaccat780ggtttgggtgacaaagttttcttcaacttagtaaacttaacagagctgtccctggtgagg840aattccttgacagcagcgccagtgaaccttcccggcacaagcctgaggaagctttacctt900caagacaaccatatcaaccgggtacccccaaatgctttttcttatttaaggcagctgtat960cgactcgatatgtctaataataacctaagcaatttacctcagggtatctttgatgatttg1020gacaatataacccaactgattcttcgcaacaatccttggtattgtggatgcaagatgaaa1080tgggtacgagactggttacagtcgctaccggtgaaggtcaatgtgcgtgggctcatgtgc1140caagccccagaaaaggtccgtggaatggctatcaaggacctcagtgcagaactgtttgat1200tgtaaagacagtgggattgtgagcaccattcagataaccactgcaatacccaacacagca1260tatcctgctcaaggacagtggccagctcctgtgaccaaacaaccagatattaaaaacccc1320aagctcattaaggatcagcgaactacaggcagcccctcacggaaaacaattttaattact1380gtgaaatctgtcacccctgacacaatccacatatcctggagacttgctctgcctatgact1440gctctgcgactcagctggcttaaactgggccatagcccagcctttggatctataacagaa1500acaatcgtaacaggagaacgcagtgaatacttggtcaccgccctagaacctgaatcaccc1560tatagagtatgcatggttcccatggaaaccagtaacctttacctgtttgatgaaacacct1620gtttgtattgagacccaaactgcccctcttcgaatgtacaaccccacaaccaccctcaat1680cgagagcaagagaaagaaccttacaaaaatccaaatttacctttggctgccatcattggt1740ggggctgtggccctggtaagcatcgccctccttgctttggtgtgttggtatgtgcatagg1800aacgggtcactgttttcacggaactgtgcgtacagcaaagggcggaggagaaaggatgac1860tatgcagaagccggtactaagaaagacaactccatcctggaaatcagggaaacttctttc1920cagatgctaccgataagcaatgaacccatctccaaggaggagtttgtaatacacaccata1980tttcctccgaatgggatgaatctgtacaagaacaacctcagtgagagcagtagtaaccgg2040agctacagagacagtggcatcccagactcggaccactcacactcatgatgcaaggaggtc2100ccacaccagactgttccgggtttttttttaaaaaacctaagaaaggtgatggtaggaact2160ctgttctactgcaaaacactggaaaagagactgagagaagcaatgtacntgtacatttgc2220catataatttatatttaagaactttttatt2250<210>446<211>1685<212>DNA<213>大鼠<220><221>不确定<222>(1482)...(1482)<400>446gcggctcgggatggcggcccccatggaccggacccatggtggccgggcagcccgggcgct60gcggcgggctctggcgctggcctcgctggccgggctattgctgagcggcctggcgggtgc120tctccccaccctcgggcccggctggcggcgccaaaaccccgagccgccggcctcccgcac180ccgctcgctgctgctggacgccgcttcgggccagctgcgcctggagtacggcttccaccc240cgatgcggtggcctgggctaacctcaccaacgccatccgcgagactgggtgggcctatct300ggacctgggcacaaatggcagctacaagtggatcccccgggctgcaggcctatgcagctg360gtgtggtggaggcctctgtgtccgaggagctcatctacatgcactggatgaacacggtgg420tcaattactgcggccccttcgagtacgaagtcggctactgtgagaagctcaagagcttcc480tggaggccaacctggagtggatgcagagggaaatggagcttagcccggactcgccatact540ggcaccaggtgcggctgaccctcgggctgcagctgaagaggcctggaggacagctatgaa600ggccgtttaaccttcccaactgggaggttcaacatcaaacccttggggttcctcctgctg660caggaatctctggagatctggaagacctagagacagccctgaataagaccaacgaccaag720cgcttccgtgggctccggttcgtgctctgccctcatcaagctgctgcccggcagccatga780tctcctggtggctcacaacacttggaactcctaccagaacatgttacgcatcatcatgga840gtcccccgggctgcagttccgggaggggccgcaagaaggagtaccccctgattgccggca900acaacttgattttttcgtcttacccgggcaccatcttctccggtgatgacttctacatcc960tgggcagtgggctggtcaccctggagaccaccaatcggcaacaaagaacccaagcgctgt1020ggaagtacgtgcaaccccagggctgtgtgctggagtggattcgaaacattgtggccaacc1080cgcctggccttggatggggccacctgggcagatgtcttcaggcggttcaatagtggcacg1140tataataaccagtggatgattgtggactacaaggcattcatccccaatgggcccagccct1200ggaagccgggtgctcaccatcctagaacagatcccgggcatggtggtggtggcatccccc1260gggctgcaggaattcgatatcaagcttatcgatacacgtcgaaccctcgagccaagatct1320tccagagggaccagtcactagtagaggacgtagacaccatggtccggctcatgaggtaca1380atgacttccttcatgaccctctgtcgttgtgtgaggcctgcagcccgaagcccaacgcag1440agaacgccatctctgccccgctctgatctcaaccctgctaantggctcctacccatttca1500ggccctgcgtcagcgcgcccatggcggcattgatgtgaaggtgaccagcgttgcactggc1560taagtacatgagcatgctggcagccagtggccccacgtgggaccagttgccaccgttcca1620gtggagtaaatcaccattccacaacatgctgcacatgggccaagcctgatctttggatgt1680tctca1685<210>447<211>1890<212>DNA<213>大鼠<400>447gcggaagcagccgcaggtatggcggctgccatgccgctgggtttatcgttgctgttgctg60gtgctagtggggcagggctgctgtggccgcgtggagggcccacgcgacagcctgcgagag120gaactcgttatcactccgctgccttccggcgacgtggccgccacattccagttccgcacg180cgttgggattccgatctgcagcgggaaggagtgtcccattacaggctcttccctaaagcc240ctgggacagttgatctccaagtactctctgcgggagctacacctgtcattcacgcaaggc300ttttggaggacccgatactgggggccacccttcctgcaggctccatcaggtgcagagctc360tgggtctggttccaagacactgtcacagatgtggataagtcttggaaggagctcagtaat420gtcctctcagggatcttctgcgcgtccctcaacttcatcgactccaccaataccgtcact480cccacagcctccttcaaacctctggggctggccaatgacactgaccactacttcctgcgc540tatgctgtgctgccccgggaggtcgtctgcaccgagaatctcacgccgtggaagaagctc600ctgccctgtagctccaaggcagggctgtccgtgctactgaaagcagatcgattgttccac660accagttaccactcccaggcagtgcatatccggccaatctgcagaaatgctcactgcacc720agtatctcctgggagctgaggcagaccctttcagttgtctttgatgccttcatcaccgga780caggggaagaaagactggtctctcttccgcatgttctcccggactctcacagaggcctgt840ccattggcatctcagagcctagtttatgtggacatcacaggctacagccaggacaacgaa900acactggaggtgagccctcccccaacttccacataccaggatgtcattttgggcaccagg960aagacctatgccgtctatgacttgtttgacacagccatgatcaataactcccgaaacctc1020aacatccagctcaaatggaagagacccccagataatgaagccctgcccgtgcccttcctg1080catgcacagcggtacgtgagtggttatgggctacagaagggcgagctgagcaccctgttg1140tacaactctcatccttaccgggccttccctgtgctgctactggatgctgtgccctggtac1200ctgcggctgtatgtgcacaccctcaccatcacctccaagggcaaggataataaaccaagt1260tatatccactaccagcctgcccaggaccggcagcagccccacctcctggagatgctcatt1320cagctgccggccaactccgtcaccaaggtctccatccagtttgaacgagccctgctcaag1380tggacagaatacacgccagaccccaaccatggcttctatgtcagcccatctgtcctcagt1440gcccttgtgcccagcatggtggcagccaaaccagtggactgggaagagagccctctcttc1500aacaccttgttcccggtgtctgatggctccagctactttgtccgactctacacagagccc1560ttgctagtgaacctgcccacccccgacttcagcatgccctacaatgtgatctgccttaca1620tgcactgtggtggccgtgtgctatggctccttctacaatctcctcacccgaaccttccac1680attgaagagcccaaatccggcggcctggccaagcggctggctaacctcatccggcgtgct1740cgtggtgttccccctctctaagattccctttcttcagcaactacagcttcatactcacct1800gccccaggggagcagtggcagggctttttctgccatgccctctttccccagagttagctt1860ctgaagctaactccccctggatctggtctg1890<210>448<211>1272<212>DNA<213>大鼠<400>448cggcacgagcggccccgaagggggctgcacgggcgacttggcggcgatggctcgagctcc60ggcggcgacgacggtggccggaggcggcggctcctcctccttctcctcctgggcttgggc120ccggcggtgatccgagctggcggccgcggccccccgatgagactgttggcgggctggctg180tgcctgagcctggcgtccgtgtggctggcgcggaggatgtggacgctgcggagcccgctc240tcccgctctctgtacgtgaacatgactagcggccctggcgggccagcggcggccacgggc300ggcgggaaggacacgcaccagtggtatgtgtgcaacagagagaaattatgcgaatcactt360cagtctgtctttgttcagagttatcttgaccaaggaacacagatcttcttaaacaacagc420attgagaaatctggctggctatttatccaactctatcattcttttgtatcatctgttttt480agcctgtttatgtctagaacatctattaacgggttgctaggaagaggctccatgtttgtg540ttctcaccagatcagtttcagagactgcttaaaattaatccggactggaaaacccataga600cttcttgatttaggtgctggagatggagaagtcacgaaaatcatgagccctcattttgaa660gaaatttatgccactgaactttctgaaacaatgatctggcagctccagaagaagaaatac720agagtgcttggtataaatgaatggcagaatacagggttccagtatgatgtcatcagctgc780ttaaatctgctggatcgctgtgatcagcctctgacattgttaaaagatatcagaagtgtc840ttggagcccacccaaggcagggtcatcctggccttggttttgccctttcatccctatgtg900gaaaacgtaggtggcaagtgggagaaaccatcagaaattctggaaatcaagggacagaat960tgggaagagcaagtgaatagcctgcctgaggtgttcaggaaagctggctttgtcatcgaa1020gctttcactagactgccatacctgtgtgaaggtgacatgtacaatgactactatgttctg1080gacgacgctgtctttgttctcagaccagtgtaaacatgtggaggcccaagtcttcagagt1140cacccctggaatctgccctccagaagaggaggtgcatccagtgatgtgagggggacctct1200ggggactgtcattctcagtatcatgtaggaatttaaaaagccaaaatactaattctttct1260ttgtagtgtgta1272<210>449<211>936<212>DNA<213>大鼠<400>449gggccgccgagtcccgccgggtcggtgtagctcgctgccgacgctgcgacgctcgtgggt60gccgtgttcggcttttcctgtctacttcagtgcaccgctgcagctccggcctcgggtctg120acgcgccacagcatggcttccgctttggaggagttgcagaaagacctagaagaggtcaaa180gtgctgctggaaaagtccactaggaaaagactacgtgatactcttacaaatgaaaaatcc240aagattgagacggaactaaggaacaagatgcagcagaagtcacagaagaaaccagaattt300gataatgaaaagccagctgctgtggttgctcctcttacaacagggtacactgtgaaaatc360agtaattatggatgggatcagtcagataagtttgtgaaaatctacattactttaactgga420gttcatcaggttcctgctgagaatgtgcaagtacacttcacagagaggtcatttgatctt480ttggtaaaaaacctcaatggcaagaattactccatgattgtgaacaatcttttgaaacct540atctctgtggaaagcagttcaaaaaaagtcaagactgatacagttattatcctatgtaga600aagaaagcagaaaacacacgatgggactacttaactcaggtggaaaaagaatgcaaagag660aaagaaaagccttcctacgacactgaggcagatcctagtgagggattaatgaatgttcta720aagaaaatttatgaagatggagatgatgacatgaagcgaaccattaataaagcgtgggtg780gaatcccgagagaagcaagccagggaagacacagaattctgaggctttaaaagtcctgtg840ggaaccgtcatgtggagtgctcgtgtttccagtagggactgttggtgaactgcacacatg900tgttcatgtgggtatgtagttttggacagatgacta936<210>450<211>433<212>DNA<213>小鼠<400>450aaagttctttttcttttctttttcttttttttgtgtgtgtgtgttttggtttgttgttgt60tttggttttcctggaactcactctgtagaccagctagccccaaactcagaaatctgcctc120ccgagtgctgggactaagggtgtgcaccaccactgccctggtgcagatgactcctttaag180gagctagagtaacccttgttcgcctcggtgagagtctgagaatcaggcgctttggctaca240cagctcaatttacacagccaagcctttagcttctatgtgtgctgggcatggacagagcct300cctcatcgccagtgatgatggccgggtttccaggcagccgtggtcctgtctgaatattgt360ctctaactgccacagtttcagagaaaggggaacaagttctcctttgcttcttgccctccc420agatagacccttg433<210>451<211>1225<212>DNA<213>小鼠<400>451agaacattcgagaatatgttcggtggatgatgtattggattgtctttgcgatcttcatgg60cagcagaaaccttcacagacatcttcatttcctggtccggcccaaggattggcaggccat120ggggttgggaagggcctcaccaccaccaccacctggcctctggctcacacaaacccctcc180ccttgcttacacacaggttcccgttttattacgagttcaagatggcttttgtgctgtggc240tgctctcaccttacaccaagggggccagcctgctttaccgaaagtttgtccacccatccc300tatcccgccatgagaaggagatcgacgcatgtatcgtgcaggcaaaggagcgcagctatg360aaaccatgctcagttttgggaagcggagcctcaacatcgctgcctcagctgctgtgcagg420ctgctaccaagagtcaaggcgctctagctggaaggctacggagtttctctatgcaagacc480tgcgctctatccctgacacccctgtccccacctaccaagatcccctctacctggaagacc540aggtaccccgacgtagaccccctattggataccggccaggcggcctgcagggcagtgaca600cagaggatgagtgttggtcagacaatgagattgtcccccagccacctgttgggccccgag660agaagcctctaggccgcagccagagccttcgggtggtcaagaggaagccattgactcgag720agggcacctcacgctccctgaaggtccgaaccccgaaaaaggccatgccctcagacatgg780acagctagagtctgcagattgaggccaccttacctctggagccagcaggggacctttcgc840tgctacaccagctaccggggttctgctccgtctggcttgtgcctaaatggcacatggcgt900ggtaccctgcacagggagacattcactgtaccaaagcagcccaggcctggggcctattta960ttgccttcctctgccttttgctttctcagacatgggaccagagccccaccagtccctacc1020gacgaaaccaaaagtccaaccagctgtgttcattccttcttgtccttcaaaatacttgac1080agccttttccaaggcctggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt1140ttacgtacactagctgcatgtttcgtgttggtgagtgaggtcaggcttatgaatattttt1200atataaataaataccaaacagtgaa1225<210>452<211>445<212>DNA<213>小鼠<400>452caaatgcttacttttctggtgcagaaagattgttgggaacagacaggaaccaatgtggga60attcaacttcaagttcaaaaaacagtcccctaggttaaagagcaagtgtacaggaggatt120gcagcctcccgttcagtacgaagatgttcataccaatccagaccaggactgctgcctact180gcaggtcaccaccctcaatttcatctttattccgattgtcatgggaatgatatttactct240gtttactatcaatgtgagcacggacatgcggcatcatcgagtgagactggtgttccaaga300ttcccctgtccatggtggtcggaaactgcgcagtgaacagggtgtgcaagtcatcctgga360ccagtgcacagcgttcggctctttgactggtggcatcctcagtacccattctccctgaga420gcgtagttactgcttcccatccctt445<210>453<211>2792<212>DNA<213>小鼠<400>453gaagagccgtgcaataatgggtctgaaatccttgcttataacatcgatctgggagacagc60tgcattactgtgggcaacactaccacacacgtgatgaagaacctccttccagaaacgaca120taccggatcagaattcaggctatcaatgaaattggagttggaccatttagtcagttcatt180aaagcaaaaactcggccattaccgccttcgcctcctaggcttgagtgtgctgcgtctggt240cctcagagcctgaagctcaagtggggagacagtaactccaagacacatgctgctggtgac300atggtgtacacactacagctggaagacaggaacaagaggtttatctcaatctaccgagga360cccagccacacctacaaggtccagagactgacagagtttacctgctactccttcaggatc420caggcaatgagcgaggcaggggaggggccttactcagaaacctacaccttcagcacaacc480aaaagcgtgcctcccaccctcaaagcacctcgagtgacgcagttagaagggaattcctgt540gaaatcttctgggagacggtaccaccgatgagaggcgaccctgtgagctacgttctacag600gtgctggttggaagagactctgagtacaagcaggtgtacaagggagaagaagccacattc660caaatctcaggcctccagagcaacacagattacaggttccgcgtgtgtgcctgccgccgc720tgtgtggacacgtctcaggagctcagtggcgcgttcagcccctctgcggctttcatgtta780caacagcgtgaggttatgcttacaggggacctgggaggcatggaagaggccaagatgaag840ggcatgatgcccaccgacgaacagtttgctgcactcatcgtgcttggcttcgcgaccctg900tccattttgtttgcctttatattacagtacttcttaatgaagtaaatccagcaggccagt960ggtatgctcggaacgccacacgttttaatacacatttactcagagcctcccctttttacg1020ctgtttcgttctttgatttatacgcttctcttgttttacacatttagctaggggaaagag1080tttggctgcacctatttgagatgcaaaactaggaagaggttaaactggatttttttttaa1140acaataataaataaaggaataaagaagagaaggaagcggcgggcaagctccagacaccga1200gagccagtgtgcccaacgagcttgccttgtcgggcttccccgtgtgcttctggtctgttc1260ccactgatgtctttcgcaagcctttgatcatcttgtgtgttacagttcagtaatttatat1320tcacagtcatttcttgatcatctatacctgttaacagaatcacagtgtatgtagttcagg1380gctgggattccggtgttgtcagagtattgccacatgagaatattcagtgtgccttcggag1440gaggccacctcgaccatccttacgtcactcagttacgtaactgtgttagctcatctaagt1500caaagtgtgtactttaatctaaaatgttttattactctgtatcccttatgattttaacac1560tatgagttgcctgtctaagaagtcacataaccaaatgcgcctataaatgatagagcattg1620tagattttcacatcggtccatagcagtaactttaagagggcattgtgcaatagttagttg1680tttcttgttcggctactttaaaagctgctttaacttgtctgtctgtctttgtacataact1740acttctaatataatcactagagttattatattctgttatgtttgaccggaattatgtgac1800gagagctcatggcagttgtgaactgtctccttacatgttggcccatcatatttgaaagac1860ttgcctttggctattctttggggtgtcagtgacgtgaatgaagttgaataccatatttca1920gtgcccatgatactaatgtagcagtagatagaaatcttactgataaagcccaccacaagg1980gaaccatttacatttgtcctgtttctgggggcttcatctggccgcatggagagagggagt2040ggaaactggctgtgagcatgagatgtttgggggccaaagagcctactagattctctccct2100gggtctgtcactaatttgctttgtgacctctctgtgcctgttttcccatgcatgagtaat2160caaatcaaatggggattcaatacctgtaagtgctaagagaccttggatccaccggtgcta2220tgtaagtgcggagaatcactctcacggattcacttagagtcatgaggtaatgagttctaa2280cccaaagtcattggatccctcaaccaagtccacaatgttcaagtacctcagggacactta2340agaagttggaggtgcaactgtattccaaaagggtgcgacagacacagccgattcccctct2400tcctgtttttttgtatatttttgctccttggtttttcttgatcatagctactttgtgctt2460ggtctatgttgtctatgatgcagtaagtaccctgtactagcttatactattcccatacca2520aagtcatggggaaaccaacattattttgttttgggtttatttatactctattctgcatac2580agtactttaaatgccaatgacagtgcaatctttatttattgtaatgttaaatgtacttat2640tactaatgtgccctcctagcatgttatattttgtgtgttttatactttttgtaattttag2700gtcagtttagttccttggcaacatctgtagtattagccttctgacatctttcttgtgttt2760ttaaagataagagcatctaactcattaaatgc2792<210>454<211>1808<212>DNA<213>小鼠<400>454gacttctgctagtacttgctcctggcggtggctgagcaaccggtctcaccagcatgctct60gcctgtgcctgtatgtgcccatcgccggggcggctcagactgagttccagtactttgagt120ccaaggggcttcctgccgagctgaaatccatcttcaaactcagtgtctttatcccctctc180aagagttctccacataccgccaatggaagcagaaaattgtgcaagcaggtgacaaggacc240ttgatgggcaactggactttgaagagtttgtacattacctccaagatcatgagaaaaaac300tgaggctggtgttcaagagtctggacaaaaagaatgatggtcgaatcgatgctcaggaga360tcatgcagtccctgcgggacctgggtgtcaagatctcggaacagcaggcggagaagattc420ttaagagcatggataagaatggcacgatgaccatcgactggaacgagtggagggactacc480acctcctgcaccctgtggagaacatcccggagatcatcctgtactggaagcactcgacga540tcttcgatgtcggtgagaatctgacagtcccagatgagttcacagtggaggagaggcaga600cggggatgtggtggaggcacctggtggcaggaggtggggcaggggcagtttccagaacct660gcactgcccccctggacagactgaaggtgctcatgcaggtccatgcctcccgcagcaaca720acatgtgcatcgtaggtggattcacacagatgattcgagaagggggagccaagtcactct780ggcggggcaacggcatcaatgtcctcaaaattgcccctgagtcggccatcaaattcatgg840catatgagcagatgaaacggcttgtcggtagtgatcaggagacgctgaggatccacgaaa900ggcttgtggcaggctccttggccggagccattgcccagagtagcatctacccaatggagg960ttctgaagacccgaatggccctgcggaaaacaggacagtactccggcatgctggactgtg1020ccaggaggatcttggctaaagagggtgtagctgccttctacaaaggctacatccccaaca1080tgctggggatcatcccctatgctggcatcgacctagctgtctatgagacattgaaaaata1140cctggctccagcgctacgcagtaaacagtgcagaccccggtgtgttcgtgctcctggcct1200gtggtactatctccagtacttgtggccagctggccagctacccactagccctggtcagga1260cccggatgcaggcacaagcctccattgagggcgcacctgaggtaaccatgagcagcctct1320tcaaacagattctgcggactgagggggcctttgggctctaccgggggctggcccccaact1380tcatgaaggtgatcccggctgtgagcatcagctacgtggtctacgaaaacctgaagatca1440ccctgggcgtgcagtctcggtgacgggagggtggtggacttggtgagcctgggctgcggc1500ccagggtatgcagccacctcattctgtgaatgtgccaacactaagctgacttacccaagc1560tgtgaaacccaggataccataggggacgggcagggagctggcaagctctgggctggttct1620gctgacctggcagaccttcgtgtctcttccaaggaagacctgtggatgttccttggggtt1680caggggtcagtaagatgtaggctcctgcactagagacaggacgttttcctcagtgcctgc1740cagatagcgagcttggatgccagcttagttcttccatctcgttcactcagccggacctca1800gccacggg1808<210>455<211>1121<212>DNA<213>大鼠<220><221>不确定<222>(1095)...(1095)<400>455gcggtcagaacccgggcttctcgtttgtcctgaacggcactaccagggcggtggaagcag60agatggcggagggcggtgggaggagaggcgtctagtcttgctggctcagcaagcccgata120agcatgaagctgctgtgtttggtggctgtggtggggtgcttgctggtacccccggctcaa180gccaacaagagctctgaagatatccggtgcaaatgcatctgtcccccttacagaaacatc240agcgggcacatttacaaccagaatgtgtctcagaaggactgcaactgcctgcatgtggtg300gagcccatgccggtgcctggccatgatgtggaagcctactgcctgctctgtgagtgtagg360tatgaggagcgcagcaccacaaccatcaaggtcattatcgtcatctacctgtctgtggta420ggggccctcttactctacatggccttcctgatgctggtggaccctctcatccgaaagccg480gatgcctatactgagcagctgcacaatgaagaagagaatgaggatgcccgctccatggct540gccgccgccgcatccattggaggaccccgagcaaacaccgtcctggagcgggtggaaggc600gctcagcagcgatggaagctacaggtgcaggagcagcggaagacggtcttcgatcgacac660aagatgctcagttagatgattgccatggcagtgtcagggacccagacctcggctaccagc720ttctggggcagtcttccctgggtcttcccttcaaatgcccgtggcatttgtccttctccc780tctctctagaaatgtactcgactgttataactagggagtgggattgggtctttggtctct840agtgtctctgtaggtctctggggtagaagggagggaaaggaaggcagaagagaacagaga900tggttgagacggccacacgattggtgaaattcctccctcctgtcctcgccgttcctcaca960gctccacatcttaaggatgtttatagctctttgggagacggagctgtgccgtcaatagct1020cggtgggtgcgacgaaagtgtgacccagccctcagcctgtgctctacgatgccgtggccc1080ccattcccacttttncagtgccaatactttagcttggcctg1121<210>456<211>75<212>蛋白质<213>小鼠<400>456LysProLeuProMetGluAlaHisSerArgArgGluLysAlaSerGly151015LeuArgLeuAlaTrpHisTyrGluCysSerGlyValSerValTrpTrp202530MetCysValLeuGlyTrpLeuSerPheLeuValPheLeuLeuPheSer354045LeuValCysSerPheProSerProIleAsnHisSerHisMetLeuPro505560CysLeuPheLeuArgGlyGlyGlySerAsnVal657075<210>457<211>49<212>蛋白质<213>大鼠<400>457ThrAlaCysArgValSerIleSerValLeuTyrMetLeuHisThrGlu151015LeuLysLysCysTrpPhePheLeuPheCysPheSerLeuPheLeuTrp202530PheCysPheTrpPheCysPheLeuLeuProArgPheAspTyrLeuPro354045Met<210>458<211>296<212>蛋白质<213>小鼠<400>458GlyAlaCysTyrCysProAlaGlyPheLeuGlyAlaAspCysSerLeu151015AlaCysProGlnGlyArgPheGlyProSerCysAlaHisValCysThr202530CysGlyGlnGlyAlaAlaCysAspProValSerGlyThrCysIleCys354045ProProGlyLysThrGlyGlyHisCysGluArgGlyCysProGlnAsp505560ArgPheGlyLysGlyCysGluHisLysCysAlaCysArgAsnGlyGly65707580LeuCysHisAlaThrAsnGlySerCysSerCysProLeuGlyTrpMet859095GlyProHisCysGluHisAlaCysProAlaGlyArgTyrGlyAlaAla100105110CysLeuLeuGluCysSercysGlnAsnAsnGlySerCysGluProThr115120125SerGlyAlaCysLeuCysGlyProGlyPheTyrGlyGlnAlaCysGlu130135140AspThrCysProAlaGlyPheHisGlySerGlyCysGlnArgValCys145150155160GluCysGlnGlnGlyAlaProCysAspProValSerGlyArgCysLeu165170175CysProAlaGlyPheArgGlyGlnPheCysGluArgGlyCysLysPro180185190GlyPhePheGlyAspGlyCysLeuGlnGlnCysAsnCysProThrGly195200205ValProCysAspProIleSerGlyLeuCysLeuCysProProGlyArg210215220AlaGlyThrThrCysAspLeuAspCysArgArgGlyArgPheGlyPro225230235240GlyCysAlaLeuArgCysAspCysGlyGlyGlyAlaAspCysAspPro245250255IleSerGlyGlnCysHisCysValAspSerTyrThrGlyProThrCys260265270ArgGluValProThrGlnLeuSerSerIleArgProAlaProGlnHis275280285SerSerSerLysAlaMetLysHis290295<210>459<211>106<212>蛋白质<213>小鼠<400>459ValGlyThrProTyrTyrMetSerProGluArgIleHisGluAsnGly151015TyrAsnPheLysSerAspIleTrpSerLeuGlyCysLeuLeuTyrGlu202530MetAlaAlaLeuGlnSerProPheTyrGlyAspLysMetAsnLeuTyr354045SerLeuCysLysLysIleGluGlnCysAspTyrProProLeuProSer505560AspHisTyrSerGluGluLeuArgGlnLeuValAsnIleCysIleAsn65707580ProAspProGluLysArgProAspIleAlaTyrValTyrAspValAla859095LysArgMetHisAlaCysThrAlaSerThr100105<210>460<211>53<212>蛋白质<213>小鼠<400>460MetCysAlaGlyHisGlyGlnSerLeuLeuIleAlaSerAspAspGly151015ArgValSerArgGlnProTrpSerCysLeuAsnIleValSerAsnCys202530HisSerPheArgGluArgGlyThrSerSerProLeuLeuLeuAlaLeu354045ProAspArgProLeu50<210>461<211>261<212>蛋白质<213>小鼠<400>461AsnIleArgGluTyrValArgTrpMetMetTyrTrpIleValPheAla151015IlePheMetAlaAlaGluThrPheThrAspIlePheIleSerTrpSer202530GlyProArgIleGlyArgProTrpGlyTrpGluGlyProHisHisHis354045HisHisLeuAlaSerGlySerHisLysProLeuProLeuLeuThrHis505560ArgPheProPheTyrTyrGluPheLysMetAlaPheValLeuTrpLeu65707580LeuSerProTyrThrLysGlyAlaSerLeuLeuTyrArgLysPheVal859095HisProSerLeuSerArgHisGluLysGluIleAspAlaCysIleVal100105110GlnAlaLysGluArgSerTyrGluThrMetLeuSerPheGlyLysArg115120125SerLeuAsnIleAlaAlaSerAlaAlaValGlnAlaAlaThrLysSer130135140GlnGlyAlaLeuAlaGlyArgLeuArgSerPheSerMetGlnAspLeu145150155160ArgSerIleProAspThrProValProThrTyrGlnAspProLeuTyr165170175LeuGluAspGlnValProArgArgArgProProIleGlyTyrArgPro180185190GlyGlyLeuGlnGlySerAspThrGluAspGluCysTrpSerAspAsn195200205GluIleValProGlnProProValGlyProArgGluLysProLeuGly210215220ArgSerGlnSerLeuArgValValLysArgLysProLeuThrArgGlu225230235240GlyThrSerArgSerLeuLysValArgThrProLysLysAlaMetPro245250255SerAspMetAspSer260<210>462<211>138<212>蛋白质<213>小鼠<400>462LysCysLeuLeuPheTrpCysArgLysIleValGlyAsnArgGlnGlu151015ProMetTrpGluPheAsnPheLysPheLysLysGlnSerProArgLeu202530LysSerLysCysThrGlyGlyLeuGlnProProValGlnTyrGluAsp354045ValHisThrAsnProAspGlnAspCysCysLeuLeuGlnValThrThr505560LeuAsnPheIlePheIleProIleValMetGlyMetIlePheThrLeu65707580PheThrIleAsnValSerThrAspMetArgHisHisArgValArgLeu859095ValPheGlnAspSerProValHisGlyGlyArgLysLeuArgSerGlu100105110GlnGlyValGlnValIleLeuAspGlnCysThrAlaPheGlySerLeu115120125ThrGlyGlyIleLeuSerThrHisSerPro130135<210>463<211>314<212>蛋白质<213>小鼠<400>463GluGluProCysAsnAsnGlySerGluIleLeuAlaTyrAsnIleAsp151015LeuGlyAspSerCysIleThrValGlyAsnThrThrThrHisValMet202530LysAsnLeuLeuProGluThrThrTyrArgIleArgIleGlnAlaIle354045AsnGluIleGlyValGlyProPheSerGlnPheIleLysAlaLysThr505560ArgProLeuProProSerProProArgLeuGluCysAlaAlaSerGly65707580ProGlnSerLeuLysLeuLysTrpGlyAspSerAsnSerLysThrHis859095AlaAlaGlyAspMetValTyrThrLeuGlnLeuGluAspArgAsnLys100105110ArgPheIleSerIleTyrArgGlyProSerHisThrTyrLysValGln115120125ArgLeuThrGluPheThrCysTyrSerPhcArgIleGlnAlaMetSer130135140GluAlaGlyGluGlyProTyrSerGluThrTyrThrPheSerThrThr145150155160LysSerValProProThrLeuLysAlaProArgValThrGlnLeuGlu165170175GlyAsnSerCysGluIlePheTrpGluThrValProProMetArgGly180185190AspProValSerTyrValLeuGlnValLeuValGlyArgAspSerGlu195200205TyrLysGlnValTyrLysGlyGluGluAlaThrPheGlnIleSerGly210215220LeuGlnSerAsnThrAspTyrArgPheArgValCysAlaCysArgArg225230235240CysValAspThrSerGlnGluLeuSerGlyAlaPheSerProSerAla245250255AlaPheMetLeuGlnGlnArgGluValMetLeuThrGlyAspLeuGly260265270GlyMetGluGluAlaLysMetLysGlyMetMetProThrAspGluGln275280285PheAlaAlaLeuIleValLeuGlyPheAlaThrLeuSerIleLeuPhe290295300AlaPheIleLeuGlnTyrPheLeuMetLys305310<210>464<211>1663<212>DNA<213>小鼠<400>464gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaagagcatgtccaggtaccggggccaggagcactgcct420gcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgagaa480gcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagttg540agagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagcat600aagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacattttata660gctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcatta720caagtggctttttgctgggcggttggcggggggcggggggacctcaagcctttccttttt780aaaataaggggttttgtatttgtccatatgtcaccacacatctgagctttataagcgcct840gggaggaacagtgagcatggttgagaccgttcacagcactactgctccgctccaggctta900caaagcttccgctcagagagcctggcggctctgtgcagctgccacaggctctcctgggct960tatgactggtcagagtttcagtgtgactccactgtggcccctgttgcagggcaattggga1020gcaggtccttctacatctgtgcctagaggaactcagtctacttaccagaaggagcttcat1080ccccaccccacccccacccgcaccccagctcattcccctgtcacgaccaggcaagtgatc1140cttaaaggagctgggtctttttcttgcaaactgagggtttctgaaaggtcggctgctttg1200gtagaagatgcttctgaggcatccaaagtccccagcagtgtgagaaaatgattctcgatg1260ttcgggaggacaagggaagatgcaggattagatgcaggacacacagccagagctacacat1320cctcttggcaatgggagctccccccccccaaagctttgtttctttccctcaccccaacag1380aaagtgcactccccctcagtgaatacgcaaacagcactgttctctgagttaggatgttag1440gacgatcctgcgccctgccctctcctgtgtacatattgccttcagtacccctcccccacc1500ccatgccacacactgcccctcattagaggccgcactgtatggctgtgtatctgctatgta1560aatgctgagacccctgagtgctgcatgcaggtttcatgttctttctaagatgaaaagaga1620aagtaataaaatatatttgaagttccccaaaaaaaaaaaaaaa1663<210>465<211>99<212>蛋白质<213>小鼠<400>465MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysSerMetSer505560ArgTyrArgGlyGlnGluHisCysLeuHisProLysLeuGlnSerThr65707580LysArgPheIleLysTrpTyrAsnAlaTrpAsnGluLysArgArgVal859095TyrGluGlu权利要求1.一种分离的多核苷酸，它包含选自以下的核苷酸序列(a)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述的序列；(b)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的互补序列；(c)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向互补序列；(d)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向序列；(e)根据使用上述工作参数的计算机算法BLASTP测定，与选自以上(a)-(d)中的任一种序列相同的可能性至少为99％的序列；以及(f)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与选自以上(a)-(d)中的任一种序列的同一性至少为50％的核苷酸序列。2.一种表达载体，它包含权利要求1的分离多核苷酸。3.一种宿主细胞，它是用权利要求2的表达载体转化的宿主细胞。4.一种分离的多肽，它包含选自以下的氨基酸序列(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；(b)根据使用上述工作参数的计算机算法BLASTP测定，与SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465序列相同的可能性至少为99％的序列；以及(c)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列的同一性至少为50％的序列。5.一种分离的多核苷酸，它编码权利要求4的多肽。6.一种表达载体，它包含权利要求5的分离多核苷酸。7.一种宿主细胞，它是用权利要求6的表达载体转化的宿主细胞。8.一种分离的多肽，它至少包含具有选自以下的氨基酸序列的多肽的功能部分(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；(b)根据使用上述工作参数的计算机算法BLASTP测定，与SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465序列相同的可能性至少为99％的序列；以及(c)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列的同一性至少为50％的序列。9.一种刺激患者角质细胞生长和运动的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。10.权利要求9的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO187、196、342、343、395、397和398；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO187、196、342、343、395、397和398序列的同一性至少为约50％的序列。11.一种抑制患者癌细胞生长的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。12.权利要求11的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO187、196、342、343、397和398；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO187、196、342、343、397和398序列的同一性至少为50％的序列。13.一种调节患者血管发生的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。14.权利要求13的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO187、196、342、343、397和398；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO187、196、342、343、397和398序列的同一性至少为50％的序列。15.一种抑制患者肿瘤血管发生和血管形成的方法，该方法包括给予患者含权利要求4的多肽的组合物。16.权利要求15的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO187、196、342、343、397和398；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO187、196、340、342-346、397和398序列的同一性至少为50％的序列。17.一种调节患者皮肤炎症的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。18.权利要求17的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO338和347；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO338和347序列的同一性至少为50％的序列。19.一种刺激患者上皮细胞生长的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。20.权利要求19的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO129和348；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO129和348序列的同一性至少为50％的序列。21.一种抑制患者体内HIV-1结合白细胞的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。22.权利要求21的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO340、344、345、346和465；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO340、344、345、346和465序列的同一性至少为50％的序列。23.一种治疗患者炎症性疾病的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。24.权利要求23的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO340、344、345、346和465；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO340、344、345、346和465序列的同一性至少为50％的序列。25.一种治疗患者癌症的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。26.权利要求25的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO340、344、345、346和465；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO340、344、345、346和465序列的同一性至少为50％的序列。27.一种治疗患者神经性疾病的方法，该方法包括给予所述患者含权利要求4的多肽的组合物。28.权利要求27的方法，其中所述多肽包含选自以下的氨基酸序列(a)SEQIDNO187、196、340、342-346、397和398；(b)根据使用上述工作参数的计算机算法BLASTP和以上定义的同一性测试测定，与SEQIDNO187、196、340、342-346、397和398序列的同一性至少为50％的序列。全文摘要本发明提供编码哺乳动物皮肤细胞表达的多肽的分离多核苷酸以及包含所述分离多核苷酸的表达载体和宿主细胞。本发明还提供使用所述多核苷酸和多肽的方法。文档编号A61K48/00GK1373774SQ00810237公开日2002年10月9日申请日期2000年5月15日优先权日1999年5月14日发明者J·D·瓦特森,L·斯特拉钱,R·安鲁斯特,M·斯勒曼,K·D·库姆布勒,J·G·穆里森申请人:吉尼西斯研究及发展有限公司