攻击SARS病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及应用的制作方法

专利名称：攻击SARS病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及应用的制作方法
技术领域：
本发明属于基因工程领域，具体地说涉及攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰RNA分子(SiRNA)及其应用。
背景技术：
SARS是一种仅有五个月历史的新型急性传染病。第一例SARS病人于2002年11月在我国广东省被发现，在2003年2月间此病在广东得以蔓延，到2003年2月中旬，广东已有确诊人数达305例，其中死亡5例。当时因为此病的临床症状与其它病原体引起的非典型性肺炎类似，所以也将其笼统地称为非典型性肺炎(其本来的医学概念是指不是因细菌感染而是有其它病原体，主要是衣原体、支原体等微生物引起的肺部炎症)。由于此病的病因不清，不知道如何切断其传染途经，再加上没有任何的有效疗法，使得此病在过去的两个月中迅速传播到中国的大部地区和世界上的许多国家。根据WHO到2003年5月1号的统计，全球共有29个国家和地区有SARS感染病人，累计共有SARS病人5663例，其中死亡372例。中国卫生部2003年5月1日的最新疫情报道，中国大陆(不包括香港、澳门、和台湾地区)共有26个省、自治区、和直辖市发现SARS病人，累计总感染人数为3638例，其中死亡170人，另外还有2291个疑似病例。
SARS的病因在世界卫生组织和其成员国的科学家们的努力下，已经确定为一种新的冠状病毒，第一个SARS病毒全部基因组序列的测定由加拿大的科学家在2003年4月13号首先完成(基因文库登录号NC_004718)。此后，又有来自不同病人的SARS病毒的全基因组序列被美国、中国北京、和中国香港的科学家们独立地破译。到2003年5月10号，共有5个SARS病毒全基因组序列在基因文库中登录，它们分别是NC_004718，AY278488，AY278491、AY278544，和AY278741。
随着SARS病毒基因序列的破译，人们已经成功地研发出可以准确诊断SARS的有效方法，但SARS感染和大部份其它病毒感染一样，最大的问题是没有任何有效和特异的治疗手段，这使得其急性死亡率居高不下，一直在5％-10％左右。可以预测，在有效的SARS病毒疫苗问世之前，如何找到一种有效治疗SARS感染的药物是对整个人类的一个巨大挑战。

发明内容
本发明所要解决的技术问题是提供攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)。
本发明另一个所要解决的技术问题是提供上述小干扰核糖核酸分子在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
本发明提供的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，它为双链RNA分子并且其核苷酸序列与具有以下特征的核苷酸序列(I)至少70％的同源度正义链和负义链的长度均为21个核苷酸，正义链和负义链各自的3’端为两个连续的脱氧胸苷酸(TT)，两条链除去3’端的TT以外的19个核苷酸上的碱基互补形成双链，正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致，每条链中的碱基为鸟嘌呤(G)的核苷酸及胞嘧啶(C)的核苷酸数量之和占除去3’端的TT以外的19个核苷酸数量的比例为大于30％小于70％(即G/C比例)，核苷酸序列(I)和其任意一个位置的核苷酸突变体和已知人类基因和基因表达片段无同源性。
“无同源性”在此是指核苷酸序列(I)和其任意一个位置的核苷酸突变体和已知人类基因和基因表达片段无100％的相同。
根据以上所述，核苷酸序列(I)的负义链的21个核苷酸上的碱基和被攻击的SARS病毒的mRNA对应区域序列的碱基完全互补，其中3’端的两个TT和mRNA对应区域5’端的两个AA互补。
上述小干扰RNA分子(SiRNA)为人工合成，正义链和负义链各自的3’末端有两个脱氧胸甘酸(TT)，其它19个核苷酸的碱基可以是腺嘌呤(A)、鸟嘌呤(G)、胞嘧啶(C)或尿嘧啶(U)；两条链除去3’端的TT以外的19个核苷酸上的碱基互补(A和U，C和G)形成双链，但它们3’端的TT却以单链的形式存在。
当被攻击的SARS病毒mRNA分子中出现两个以上连续的碱基为腺嘌呤(A)的核苷酸时，上述“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致，”可以被理解为“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中任意两个连续的碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致。”SARS病毒的整个基因组的所有核苷酸几乎都有效地用于编码和各种功能和结构蛋白，不仅其整个线性序列都有相对应的编码蛋白外，在多个区域还有移位重复使用序列编码多个蛋白的现象。它除了编码其它冠状病毒已知功能和结构蛋白，如多功能聚合酶(polyprotein)、膜蛋白(M)、刺蛋白(S)，核复合体蛋白(N)、和小分子膜蛋白(E)以外，还可能编码五种未知功能的蛋白(uncharacterizedprotein，UP1-5)。SARS病毒是一种单链RNA病毒，其基因组是有一条正义链的RNA分子组成，当病毒感染进入细胞后，组成病毒基因组的正义链RNA分子本身无法进行复制，它需要依靠其本身为模板转录形成一条负链RNA(此过程有正义链RNA直接翻译合成的RNA依赖的RNA聚合酶来催化进行)，有此两条RNA互补形成一个复制复合体。此复合体的负义链一方面可转录编码各种病毒蛋白的mRNA，另一方面可以转录形成大量的正义链的基因组RNA，此正义链RNA与上述mRNA转录形成的各种病毒蛋白装配在一起而完成病毒的复制。从SARS病毒复制的过程来看，其是一种比较容易被SiRNA攻击的病毒。首先因为组成病毒基因组的正义链本身可以受到SiRNA攻击而降解；第二是编码病毒蛋白的所有mRNA可以用SiRNA来攻击；第三是和病毒复制直接相关的、由复制复合体转录形成的正义链RNA也可被SiRNA来作用而降解。因此特异针对SARS病毒的SiRNA分子可以起到治疗SARS以及与SARS感染相关的疾病。
SARS病毒多功能聚合酶在病毒的复制和繁殖中处于中心作用，尤其是多功能聚合酶中的RNA依赖的RNA聚合酶是整个病毒复制和繁殖过程中的关键。此酶属于RNA依赖的RNA聚合酶，不存在于任何人体细胞，因此SARS病毒复制和繁殖过程中每一次遗传信息复制和传递均需要它的作用下完成，另外病毒所有结构蛋白的mRNA的转录也要通过它的催化下完成。
SARS病毒编码的刺蛋白(S)对于病毒致病过程中的具有极大的重要性，它是SARS病毒表面最为重要的蛋白，除了本身对病毒结构的完整至关重要外，S蛋白在SARS病毒的致病中的多方面起到十分重要的作用。第一、SARS病毒和细胞表面特异性病毒受体结合的需要S蛋白来介导；第二、病毒和细胞的融合和进入细胞的过程也是有S蛋白来介导；第三、病毒感染细胞后可大量合成S蛋白并将其分布在感染细胞的表面，这些S蛋白是造成属主免疫系统杀伤感染细胞的重要原因，而此也是SARS病毒感染致死的重要因素。
因此，上述SiRNA，以攻击SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或S蛋白mRNA分子为效果更好，即前述的核苷酸序列(I)应当还具有以下特征其正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中的的连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致，其负义链相应配合。
当被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中出现两个以上连续的碱基为腺嘌呤(A)的核苷酸时，上述“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致，”仍然可以被理解为“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中任意两个连续的碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致。”以攻击SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或S蛋白mRNA分子而言，其SiRNA以更具备以下特征为治疗效果更佳即核苷酸序列(I)的GC比例在40％到60％之间；它的正义链5’端的第一个核苷酸的碱基为鸟嘌呤(G)、胞嘧啶(C)、和尿嘧啶(U)中的一种，其负义链相应配合；其序列中不具有连续三个以上碱基为G或C的核苷酸也不具有连续四个以上碱基为A或U的核苷酸。
上段中“它的正义链5’端的第一个核苷酸的碱基为鸟嘌呤(G)、胞嘧啶(C)、和尿嘧啶(U)中的一种”的意思是，当被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中出现两个以上连续的碱基为腺嘌呤(A)的核苷酸时，正义链自5’端开始的19个核苷酸序列和该两个以上连续的碱基为腺嘌呤(A)的核苷酸中的最后两个核苷酸之后的19个核苷酸序列完全一致，”。
就所有攻击SARS病毒mRNA分子的SiRNA而言，它具备以上两段的特征，其治疗效果都将更好。
经发明人的研究，确立了长度为29744个核苷酸的SARS病毒共同基准序列(见序列表的No.1序列)，对此序列进一步研究发现，在其中确定了编码RNA依赖的RNA聚合酶的区域在基因组的13372到16166之间，编码S蛋白的区域在21492到25259之间。以下列举了攻击RNA依赖的RNA聚合酶的SiRNA分子(表1)和攻击S蛋白的(表2)的小干扰RNA(SiRNA)的具体特征，它们均为上述核苷酸序列(I)的具体例证，它们的反义链的序列表列于本说明书的最后部分。
表1、攻击RNA依赖的RNA聚合酶的SiRNA分子G/C比序列号 正义链序列 反义链序列 目标基因作用范围例(％) 分子量CUAAUUGCUGUC UGGAAGCGACAG2 GCUUCCATTCAAUUAGTT RNA聚合酶 13255…13275 4713459.4UUGCUGUCGCUU CUCCUGGAAGCG3 CCAGGAGTTACAGCAATT RNA聚合酶 13259…13279 5813489.6GGAUGAGGAAGG UAAAUUGCCUUC4 CAAUUUATTCUCAUCCTT RNA聚合酶 13280…13300 4213444.3GAGGCAUACUAU GUUAGACAUAGU5 GUCUAACTTAUGCCUCTT RNA聚合酶 13322…13342 4213444.3CUACCAACAUGA AGUCUCUUCAUG6 AGAGACUTTUUGGUAGTT RNA聚合酶 13340…13360 4213444.3GAUUGUCCAGCG CAGCAACCGCUG7 GUUGCUGTTGACAAUCTT RNA聚合酶 13377…13397 5813489.6
GUUUAGAGUAGA GUCACCAUCUAC8UGGUGACTTUCUAAACTT RNA聚合酶 13412…13432 42 13444.3UGGCUGAUUUAG GCAUAGACUAAA9UCUAUGCTTUCAGCCATT RNA聚合酶 13474…13494 42 13444.3GAAGGAUUGGUA GAAGUCAUACCA10 UGACUUCTTAUCCUUCTT RNA聚合酶 13580…13600 42 13444.3GGAUUGGUAUGA UACGAAGUCAUA11 CUUCGUATTCCAAUCCTT RNA聚合酶 13583…13603 42 13444.3UCCUGACAUCUU UACGCGUAAGAU12 ACGCGUATTGUCAGGATT RNA聚合酶 13607…13627 47 13459.4CUUAGGUGAGCG GCGUACACGCUC13 UGUACGCTTACCUAAGTT RNA聚合酶 13634…13654 58 13489.6GACUGUACAAUU AUCGCAGAAUUG14 CUGCGAUTTUACAGUCTT RNA聚合酶 13667…13687 42 13444.3UUCUGCGAUGCU CACGCAUAGCAU15 AUGCGUGTTCGCAGAATT RNA聚合酶 13677…13697 53 13474.5CUGGUACGAUUU AUCACCGAAAUC16 CGGUGAUTTGUACCAGTT RNA聚合酶 13748…13768 47 13459.4GAGAGACUUUGU CGAAGAGACAAA17 CUCUUCGTTGUCUCUCTT RNA聚合酶 13935…13955 47 13459.4CUGUUUGGAUGA ACACCUAUCAUC18 UAGGUGUTTCAAACAGTT RNA聚合酶 14003…14023 42 13444.3CUUACAUAGCUC GAGACGCGAGCU19 GCGUCUCTTAUGUAAGTT RNA聚合酶 14183…14203 53 13474.5GGAAGGAAGUUC UUCAACAGAACU20 UGUUGAATTUCCUUCCTT RNA聚合酶 14393…14413 42 13444.3CACUUCUUCUUU CCUGAGCAAAGA21 GCUCAGGTTAGAAGUGTT RNA聚合酶 14418…14438 47 13459.4CGCUGCUAUCAG AUAAUCACUGAU22 UGAUUAUTTAGCAGCGTT RNA聚合酶 14444…14464 42 13444.3UCUGCCAACAAU AUCACACAUUGU23 GUGUGAUTTUGGCAGATT RNA聚合酶 14480…14500 42 13444.3CUCCUAUUCGUA CUUCAACUACGA24 GUUGAAGTTAUAGGAGTT RNA聚合酶 14508…14528 42 13444.3
UGCCAACCAAGU AACGAUUACUUG25 AAUCGUUTTGUUGGCATT RNA聚合酶 14570…14590 42 13444.3UCUGGAUAAAUC ACCAGCUGAUUU26 AGCUGGUTTAUCCAGATT RNA聚合酶 14594…14614 42 13444.3GUAUGCCAUUAG CUUUGCACUAAU27 UGCAAAGTTGGCAUACTT RNA聚合酶 14738…14758 42 13444.3GAAUAGAGCUCG UACGGUGCGAGC28 CACCGUATTUCUAUUCTT RNA聚合酶 14756…14776 53 13474.5UAGAGCUCGCAC AGCUACGGUGCG29 CGUAGCUTTAGCUCUATT RNA聚合酶 14759…14779 58 13489.6GUCAAUAGCCGC UCUAGUGGCGGC30 CACUAGATTUAUUGACTT RNA聚合酶 14834…14854 53 13474.5UGUGACAGAGCC UAGGCAUGGCUC31 AUGCCUATTUGUCACATT RNA聚合酶 14967…14987 53 13474.5CAUGCUUAGGAU GGCCAUUAUCCU32 AAUGGCCTTAAGCAUGTT RNA聚合酶 14987…15007 47 13459.4UGGCCUCUCUUG GCAAGAACAAGA33 UUCUUGCTTGAGGCCATT RNA聚合酶 15001…15021 53 13474.5CUUAUCACACCG GUAGAAACGGUG34 UUUCUACTTUGAUAAGTT RNA聚合酶 15044…15064 42 13444.3CGAGUGUGCGCA UAAUACUUGCGC35 AGUAUUATTACACUCGTT RNA聚合酶 15074…15094 47 13459.4GUGAGAUGGUCA CCACACAUGACC36 UGUGUGGTTAUCUCACTT RNA聚合酶 15094…15114 53 13474.5CCAGGUGGAACA CGGAUGAUGUUC37 UCAUCCGTTCACCUGGTT RNA聚合酶 15132…15152 58 13489.6CAUCAUCCGGUG GUAGCAUCACCG38 AUGCUACTTGAUGAUGTT RNA聚合酶 15142…15162 53 13474.5GCUGUUACAGCC UUACAUUGGCUG39 AAUGUAATTUAACAGCTT RNA聚合酶 15198…15218 42 13444.3GAUAGCUGACAA GACAUACUUGUC40 GUAUGUCTTAGCUAUCTT RNA聚合酶 15245…15265 42 13444.3GUAUGUCCGCAA UUGUAGAUUGCG41 UCUACAATTGACAUACTT RNA聚合酶 15257…15277 42 13444.3
UCUACAACACAG AUAGAGCCUGUG42 GCUCUAUTTUUGUAGATT RNA聚合酶 15269…15289 42 13444.3CACAGGCUCUAU GACACUCAUAGA43 GAGUGUCTTGCCUGUGTT RNA聚合酶 15276…15296 53 13474.5CAGUAACUAUGC UUGAGCCGCAUA44 GGCUCAATTGUUACUGTT RNA聚合酶 15404…15424 47 13459.4CUAUGCGGCUCA UAAACCUUGAGC45 AGGUUUATTCGCAUAGTT RNA聚合酶 15410…15430 47 13459.4UGUGUUCAUGUC UGCCUCAGACAU46 UGAGGCATTGAACACATT RNA聚合酶 15476…15496 47 13459.4UGUUGGACUGAG GGUCAGUCUCAG47 ACUGACCTTUCCAACATT RNA聚合酶 15498…15518 53 13474.5CAAGGAGAUGAU ACACGUAAUCAU48 UACGUGUTTCUCCUUGTT RNA聚合酶 15567…15587 42 13444.3GGAGAUGAUUAC GGUACACGUAAU49 GUGUACCTTCAUCUCCTT RNA聚合酶 15570…15590 47 13459.4GAAUAUUAGGCG CAGCCUGCGCCU50 CAGGCUGTTAAUAUUCTT RNA聚合酶 15610…15630 53 13474.5UAUUAGGCGCAG AAACAGCCUGCG51 GCUGUUUTTCCUAAUATT RNA聚合酶 15613…15633 47 13459.4GGUUCGUGUCAC AUAGCCAGUGAC52 UGGCUAUTTACGAACCTT RNA聚合酶 15676…15696 53 13474.5CAUCCUAAUCAG CAUACUCCUGAU53 GAGUAUGTTUAGGAUGTT RNA聚合酶 15717…15737 42 13444.3CUAAUGAUAACA CGUGAGGUGUUA54 CCUCACGTTUCAUUAGTT RNA聚合酶 15826…15846 42 13444.3UGAUAACACCUC GUACCGUGAGGU55 ACGGUACTTGUUAUCATT RNA聚合酶 15830…15850 47 13459.4UUCACAGACUUC ACGAAGUGAAGU56 ACUUCGUTTCUGUGAATT RNA聚合酶 15926…15946 42 13444.3GUGCUGCUAUGA GACAUGGUCAUA57 CCAUGUCTTGCAGCACTT RNA聚合酶 15983…16003 53 13474.5CUGUAUCUAGGA UCAUACCUCCUA58 GGUAUGATTGAUACAGTT RNA聚合酶 16086…16106 42 13444.3
表2攻击S蛋白的SiRNA分子G/C比例序列号 正义链序列 反义链序列 目标基因 作用范围 (％) 分子量GCUCCUAAUUACA GUUGAGUGUAAUU59CUCAACTT AGGAGCTT 刺蛋白76…96 4213444.3UCAAAUGUUGUCC AACCACGGACAAC60GUGGUUTT AUUUGATT 刺蛋白280…300 4213444.3CAACAAGUCACAG CACCGACUGUGAC61UCGGUGTT UUGUUGTT 刺蛋白321…341 5313474.5CAAGUCACAGUCG AAUCACCGACUGU62GUGAUUTT GACUUGTT 刺蛋白324…344 4713459.4GUCACAGUCGGUG AAUAAUCACCGAC63AUUAUUTT UGUGACTT 刺蛋白327…347 4213444.3CACUUACGAGAGU ACACAAACUCUCG64UUGUGUTT UAAGUGTT 刺蛋白538…558 4213444.3CCUAUAGAUGUAG CACGAACUACAUC65UUCGUGTT UAUAGGTT 刺蛋白601…621 4213444.3GUUGCCUCUUGGU GUUAAUACCAAGA66AUUAACTT GGCAACTT 刺蛋白660…680 4213444.3GCCAACUACAUUU GAGCAUAAAUGUA67AUGCUCTT GUUGGCTT 刺蛋白771…791 4213444.3UGGUACAAUCACA AGCAUCUGUGAUU68GAUGCUTT GUACCATT 刺蛋白804…824 4213444.3UCACAGAUGCUGU CAAUCAACAGCAU69UGAUUGTT CUGUGATT 刺蛋白812…832 4213444.3UCCACUUGCUGAA UUUGAGUUCAGCA70CUCAAATT AGUGGATT 刺蛋白840…860 4213444.3UGCUCUGUUAAGA CAAAGCUCUUAAC71GCUUUGTT AGAGCATT 刺蛋白859…879 4213444.3GGAAUUUACCAGA UAGAGGUCUGGUA72CCUCUATT AAUUCCTT 刺蛋白889…909 4213444.3CCUUUAAGUGCUA ACGCCAUAGCACU73UGGCGUTT UAAAGGTT 刺蛋白1085…1105 4713459.4GUGCUAUGGCGUU GGCAGAAACGCCA74UCUGCCTT UAGCACTT 刺蛋白1092…1112 5813489.6GACAAAUAGCGCC UGUCCUGGCGCUA75AGGACATT UUUGUCTT 刺蛋白1181…1201 5313474.5UAGCGCCAGGACA CCAGUUUGUCCUG76AACUGGTT GCGCUATT 刺蛋白1187…1207 5813489.6
UUGCCAGAUGAUU CCAUGAAAUCAUC77UCAUGGTT UGGCAATT 刺蛋白1231…12514213444.3CCUUACAGAGUUG GUACUACAACUCU78UAGUACTT GUAAGGTT 刺蛋白1474…14944213444.3UGGACUCACUGGU ACCAGUACCAGUG79ACUGGUTT AGUCCATT 刺蛋白1587…16075313474.5CCAUUUCAACAAU GGCCAAAUUGUUG80UUGGCCTT AAAUGGTT 刺蛋白1636…16564213444.3CAAUUUGGCCGUG AAACAUCACGGCC81AUGUUUTT AAAUUGTT 刺蛋白1645…16654213444.3UUUGGCCGUGAUG CAGAAACAUCACG82UUUCUGTT GCCAAATT 刺蛋白1648…16684713459.4GUGUAAUUACACC GUUCCAGGUGUAA83UGGAACTT UUACACTT 刺蛋白1742…17624213444.3UUACACCUGGAAC GCAUUUGUUCCAG84AAAUGCTT GUGUAATT 刺蛋白1748…17684213444.3UGCUUCAUCUGAA AGCAACUUCAGAU85GUUGCUTT GAAGCATT 刺蛋白1764…17844213444.3GAUGUUAACUGCA CAUCAGUGCAGUU86CUGAUGTT AACAUCTT 刺蛋白1795…18154213444.3CUGCACUGAUGUU UGUAGAAACAUCA87UCUACATT GUGCAGTT 刺蛋白1803…18234213444.3UUCAUGCAGAUCA GUGAGUUGAUCUG88ACUCACTT CAUGAATT 刺蛋白1826…18464213444.3GCAGGCUGUCUUA CUCCUAUAAGACA89UAGGAGTT GCCUGCTT 刺蛋白1894…19145313474.5CACCAUUGCUAUA AGUAGGUAUAGCA90CCUACUTT AUGGUGTT 刺蛋白2073…20934213444.3GUAAUGCCUGUUU CCAUAGAAACAGG91CUAUGGTT CAUUACTT 刺蛋白2119…21394213444.3
UGCCUGUUUCUAU UUAGCCAUAGAAA92GGCUAATT CAGGCATT 刺蛋白2123…21434213444.3UAUGUACAUCUGC AUCUCCGCAGAUG93GGAGAUTT UACAUATT 刺蛋白2160…21804213444.3UGUGCUAAUUUGC GGAGAAGCAAAUU94UUCUCCTT AGCACATT 刺蛋白2188…22084213444.3CUAAAUCGUGCAC CUGAGAGUGCACG95UCUCAGTT AUUUAGTT 刺蛋白2230…22504713459.4UCGUGCACUCUCA AAUACCUGAGAGU96GGUAUUTT GCACGATT 刺蛋白2235…22554713459.4CAGGAUCGCAACA CACGUGUGUUGCG97CACGUGTT AUCCUGTT 刺蛋白2263…22835813489.6CACACGUGAAGUG AGCGAACACUUCA98UUCGCUTT CGUGUGTT 刺蛋白2274…22945313474.5GUGUUCGCUCAAG GUUUGACUUGAGC99UCAAACTT GAACACTT 刺蛋白2284…23044713459.4UAAGGUGACACUC AUCAGCGAGUGUC100 GCUGAUTT ACCUUATT 刺蛋白2415…24354713459.4GGUGACACUCGCU AGCAUCAGCGAGU101 GAUGCUTT GUCACCTT 刺蛋白2418…24385813489.6GCAAUAUGGCGAA UAGGCAUUCGCCA102 UGCCUATT UAUUGCTT 刺蛋白2448…24684713459.4UAUGGCGAAUGCC CACCUAGGCAUUC103 UAGGUGTT GCCAUATT 刺蛋白2452…24725313474.5GUUCAAUGGACUU CACUGUAAGUCCA104 ACAGUGTT UUGAACTT 刺蛋白2505…25254213444.3UGGACUUACAGUG UGGCAACACUGUA105 UUGCCATT AGUCCATT 刺蛋白2511…25314713459.4UGGCAUAUAGGUU CCAUUGAACCUAU106 CAAUGGTT AUGCCATT 刺蛋白2648…26684213444.3
GCUGCAAGACGUU GUUAACAACGUCU107GUUAACTT UGCAGCTT 刺蛋白2784…28044713459.4GACGUUGUUAACC CAUUCUGGUUAAC108AGAAUGTT AACGUCTT 刺蛋白2791…28114213444.3CCAGAAUGCUCAA UAAUGCUUGAGCA109GCAUUATT UUCUGGTT 刺蛋白2802…28224213444.3UGAUAUCCUUUCG AAGUCGCGAAAGG110CGACUUTT AUAUCATT 刺蛋白2877…28974213444.3GUCGAGGCGGAGG UUUGUACCUCCGC111UACAAATT CUCGACTT 刺蛋白2902…29225813489.6UUACAGGCAGACU CUUUGAAGUCUGC112UCAAAGTT CUGUAATT 刺蛋白2933…29534213444.3GCCUUCAAACCUA GUUACAUAGGUUU113UGUAACTT GAAGGCTT 刺蛋白2951…297142 13444.3UGUCUGAGUGUGU CCAAGAACACACU114UCUUGGTT CAGACATT 刺蛋白3029…30494713459.4UUUGUCAUGAAGG GCUUUGCCUUCAU115CAAAGCTT GACAAATT 刺蛋白3185…32054213444.3UUGUGAUGUCGUU GCCAAUAACGACA116AUUGGCTT UCACAATT 刺蛋白3318…33384213444.3CACAGUUUAUGAU CAGAGGAUCAUAA117CCUCUGTT ACUGUGTT 刺蛋白3348…33684213444.3CCUGAGCUUGACU UGAAUGAGUCAAG118CAUUCATT CUCAGGTT 刺蛋白3370…33904713459.4GAAGAGCUGGACA AGUACUUGUCCAG119AGUACUTT CUCUUCTT 刺蛋白3391…34114713459.4GAGCUGGACAAGU UGAAGUACUUGUC120ACUUCATT CAGCUCTT 刺蛋白3394…34144713459.4CGCUUCUGUCGUC AAUGUUGACGACA121AACAUUTT GAAGCGTT 刺蛋白3462…34824713459.4AGAAAUUGACCGC AUUGAGGCGGUCA122CUCAAUTT AUUUCUTT 刺蛋白3486…35064213444.3
GAAAUUGACCGCC CAUUGAGGCGGUC123UCAAUGTT AAUUUCTT 刺蛋白3487…35074713459.4UUGACCGCCUCAA ACCUCAUUGAGGC124UGAGGUTT GGUCAATT 刺蛋白3491…35115313474.5UCACUCAUUGACC CUUGAAGGUCAAU125UUCAAGTT GAGUGATT 刺蛋白3529…35494213444.3UGGCCUUGGUAUG GCCAAACAUACCA126UUUGGCTT AGGCCATT 刺蛋白3577…35975313474.5UUGCCAUCGUCAU GUAACCAUGACGA127GGUUACTT UGGCAATT 刺蛋白3617…36374713459.4UCUUGCUUUGUUG GUCAUGCAACAAA128CAUGACTT GCAAGATT 刺蛋白3638…36584213444.3GUUUGAUGAGGAU AGAGUCAUCCUCA129GACUCUTT UCAAACTT 刺蛋白3708…37284213444.3以上两表列出的SiRNA可以有效抑制病毒的复制和繁殖，从而起到治疗SARS以及与SARS感染相关的疾病。
SARS病毒的全基因组可分为7个连续的编码区。第一编码区是从核甘酸265到21485，该区段编码两个多功能聚合酶蛋白(a和b)；第二编码区是从21492到25259，编码刺蛋白(S蛋白)；第三编码区是从25268到26347，编码三种蛋白，包括第一种未知功能蛋白(UP1，25268到26092)，第二种未知功能蛋白(UP2，25689到26153)，和小分子膜蛋白(E蛋白，26117到26347)；第四编码区是从26398到27063，编码膜蛋白(M蛋白)；第五编码区是从27074到27265，编码第三种未知功能蛋白(UP3)；第六编码区是从27273到27641，编码第四种未知功能蛋白(UP4)；第七编码区是从28120到29388，编码核核复合体蛋白(N蛋白，28120到29388)和第五种未知功能蛋白(UP5，28130-28426)。以下表格详细地列出了针对七个编码区的SiRNA分子，表1和2所列的序列未包括在内，它们均为上述核苷酸序列(I)的具体例证。在每一表格中都包括了这些分子的序号、正义链序列、反义链序列、和其分子量(MW)。它们也能起到破坏病毒表达的相应的mRNA分子的效果，因此它们也可用于治疗SARS以及与SARS感染相关的疾病。
表3、针对第一编码区的SiRNA分子，SiRNA序号 正义链序列 反义链序列 MWS1CGAGAAAACACACGUCCAATTUUGGACGUGUGUUUUCUCGTT 13459.4S2AACACACGUCCAACUCAGUTTACUGAGUUGGACGUGUGUUTT 13459.4
S3 ACACACGUCCAACUCAGUUTT AACUGAGUUGGACGUGUGUTT 13459.4S4 CACACGUCCAACUCAGUUUTT AAACUGAGUUGGACGUGUGTT 13459.4S5 CUCAGUUUGCCUGUCCUUCTT GAAGGACAGGCAAACUGAGTT 13474.5S6 GAGGCCCUAUCGGAGGCACTT GUGCCUCCGAUAGGGCCUCTT 13519.8S7 CACCUCAAAAAUGGCACUUTT AAGUGCCAUUUUUGAGGUGTT 13444.3S8 AAAUGGCACUUGUGGUCUATT UAGACCACAAGUGCCAUUUTT 13444.3S9 AAUGGCACUUGUGGUCUAGTT CUAGACCACAAGUGCCAUUTT 13459.4S10AUGGCACUUGUGGUCUAGUTT ACUAGACCACAAGUGCCAUTT 13459.4S11UGGCACUUGUGGUCUAGUATT UACUAGACCACAAGUGCCATT 13459.4S12AAAGGCGUACUGCCCCAGCTT GCUGGGGCAGUACGCCUUUTT 13504.7S13AAGGCGUACUGCCCCAGCUTT AGCUGGGGCAGUACGCCUUTT 13504.7S14AGGCGUACUGCCCCAGCUUTT AAGCUGGGGCAGUACGCCUTT 13504.7S15GGCGUACUGCCCCAGCUUGTT CAAGCUGGGGCAGUACGCCTT 13519.8S16CAGCCCUAUGUGUUCAUUATT UAAUGAACACAUAGGGCUGTT 13444.3S17ACGUUCUGAUGCCUUAAGCTT GCUUAAGGCAUCAGAACGUTT 13459.4S18CGUUCUGAUGCCUUAAGCATT UGCUUAAGGCAUCAGAACGTT 13459.4S19GCACCAAUCACGGCCACAATT UUGUGGCCGUGAUUGGUGCTT 13489.6S20UCACGGCCACAAGGUCGUUTT AACGACCUUGUGGCCGUGATT 13489.6S21GGUCGUUGAGCUGGUUGCATT UGCAACCAGCUCAACGACCTT 13489.6S22AUGGACGGCAUUCAGUACGTT CGUACUGAAUGCCGUCCAUTT 13474.5S23UGGACGGCAUUCAGUACGGTT CCGUACUGAAUGCCGUCCATT 13489.6S24CACUGGGAGUACUCGUGCCTT GGCACGAGUACUCCCAGUGTT 13504.7S25ACCCCAAUUGCAUACCGCATT UGCGGUAUGCAAUUGGGGUTT 13474.5S26CCCCAAUUGCAUACCGCAATT UUGCGGUAUGCAAUUGGGGTT 13474.5S27UUGCAUACCGCAAUGUUCUTT AGAACAUUGCGGUAUGCAATT 13444.3S28UGUUCUUCUUCGUAAGAACTT GUUCUUACGAAGAAGAACATT 13429.2S29GAACGGUAAUAAGGGAGCCTT GGCUCCCUUAUUACCGUUCTT 13474.5S30CGGUAAUAAGGGAGCCGGUTT ACCGGCUCCCUUAUUACCGTT 13489.6S31UAAGGGAGCCGGUGGUCAUTT AUGACCACCGGCUCCCUUATT 13489.6S32GGGAGCCGGUGGUCAUAGCTT GCUAUGACCACCGGCUCCCTT 13519.8S33AGUCUUAUGACUUAGGUGATT UCACCUAAGUCAUAAGACUTT 13429.2S34GUCUUAUGACUUAGGUGACTT GUCACCUAAGUCAUAAGACTT 13444.3S35GAUUAUGAACAAAACUGGATT UCCAGUUUUGUUCAUAAUCTT 13414.1S36CAAAACUGGAACACUAAGCTT GCUUAGUGUUCCAGUUUUGTT 13444.3
S37AACUGGAACACUAAGCAUGTT CAUGCUUAGUGUUCCAGUUTT 13444.3S38ACUGGAACACUAAGCAUGGTT CCAUGCUUAGUGUUCCAGUTT 13459.4S39CUGGAACACUAAGCAUGGCTT GCCAUGCUUAGUGUUCCAGTT 13474.5S40CACUAAGCAUGGCAGUGGUTT ACCACUGCCAUGCUUAGUGTT 13474.5S41GCAUGGCAGUGGUGCACUCTT GAGUGCACCACUGCCAUGCTT 13504.7S42CUCACUCGUGAGCUCAAUGTT CAUUGAGCUCACGAGUGAGTT 13474.5S43UGGAGGUGCAGUCACUCGCTT GCGAGUGACUGCACCUCCATT 13504.7S44CAAUUUCUGUGGCCCAGAUTT AUCUGGGCCACAGAAAUUGTT 13459.4S45UUUCUGUGGCCCAGAUGGGTT CCCAUCUGGGCCACAGAAATT 13489.6S46AGAUUUUCUCGCACGCGCGTT CGCGCGUGCGAGAAAAUCUTT 13489.6S47GAUUUUCUCGCACGCGCGGTT CCGCGCGUGCGAGAAAAUCTT 13504.7S48GUCAAUGUGCACUCUUUCCTT GGAAAGAGUGCACAUUGACTT 13459.4S49UGUGCACUCUUUCCGAACATT UGUUCGGAAAGAGUGCACATT 13459.4S50CAACUUGAUUACAUCGAGUTT ACUCGAUGUAAUCAAGUUGTT 13429.2S51CUUGAUUACAUCGAGUCGATT UCGACUCGAUGUAAUCAAGTT 13444.3S52GAGAGGUGUCUACUGCUGCTT GCAGCAGUAGACACCUCUCTT 13489.6S53AUUGCCUGGUUCACUGAGCTT GCUCAGUGAACCAGGCAAUTT 13474.5S54UUGCCUGGUUCACUGAGCGTT CGCUCAGUGAACCAGGCAATT 13489.6S55GAGCUACGAGCACCAGACATT UGUCUGGUGCUCGUAGCUCTT 13489.6S56AUUAAGAGUGCCAAGAAAUTT AUUUCUUGGCACUCUUAAUTT 13414.1S57UUAAGAGUGCCAAGAAAUUTT AAUUUCUUGGCACUCUUAATT 13414.1S58GAGUGCCAAGAAAUUUGACTT GUCAAAUUUCUUGGCACUCTT 13444.3S59AUUUGACACUUUCAAAGGGTT CCCUUUGAAAGUGUCAAAUTT 13429.2S60UUUGACACUUUCAAAGGGGTT CCCCUUUGAAAGUGUCAAATT 13444.3S61AGGGGAAUGCCCAAAGUUUTT AAACUUUGGGCAUUCCCCUTT 13459.4S62GGGGAAUGCCCAAAGUUUGTT CAAACUUUGGGCAUUCCCCTT 13474.5S63UGCCCAAAGUUUGUGUUUCTT GAAACACAAACUUUGGGCATT 13444.3S64AGUUUGUGUUUCCUCUUAATT UUAAGAGGAAACACAAACUTT 13414.1S65GUUUGUGUUUCCUCUUAACTT GUUAAGAGGAAACACAAACTT 13429.2S66CUCAAAAGUCAAAGUCAUUTT AAUGACUUUGACUUUUGAGTT 13414.1S67AAGUCAAAGUCAUUCAACCTT GGUUGAAUGACUUUGACUUTT 13429.2S68AGUCAAAGUCAUUCAACCATT UGGUUGAAUGACUUUGACUTT 13429.2S69GUCAAAGUCAUUCAACCACTT GUGGUUGAAUGACUUUGACTT 13444.3S70AGUCAUUCAACCACGUGUUTT AACACGUGGUUGAAUGACUTT 13444.3
S71GUCAUUCAACCACGUGUUGTTCAACACGUGGUUGAAUGACTT 13459.4S72CCACGUGUUGAAAAGAAAATTUUUUCUUUUCAACACGUGGTT 13429.2S73AAGAAAAAGACUGAGGGUUTTAACCCUCAGUCUUUUUCUUTT 13429.2S74AGAAAAAGACUGAGGGUUUTTAAACCCUCAGUCUUUUUCUTT 13429.2S75GAAAAAGACUGAGGGUUUCTTGAAACCCUCAGUCUUUUUCTT 13444.3S76AAAGACUGAGGGUUUCAUGTTCAUGAAACCCUCAGUCUUUTT 13444.3S77AAGACUGAGGGUUUCAUGGTTCCAUGAAACCCUCAGUCUUTT 13459.4S78AGACUGAGGGUUUCAUGGGTTCCCAUGAAACCCUCAGUCUTT 13474.5S79GACUGAGGGUUUCAUGGGGTTCCCCAUGAAACCCUCAGUCTT 13489.6S80CAAUAUGCACUUGUCUACCTTGGUAGACAAGUGCAUAUUGTT 13444.3S81UAUGCACUUGUCUACCUUGTTCAAGGUAGACAAGUGCAUATT 13444.3S82AUGUAAUCAUUGCGAUGAATTUUCAUCGCAAUGAUUACAUTT 13414.1S83UGUAAUCAUUGCGAUGAAGTTCUUCAUCGCAAUGAUUACATT 13429.2S84UCAUUGCGAUGAAGUUUCATTUGAAACUUCAUCGCAAUGATT 13429.2S85GUUUCAUGGCAGACGUGCGTTCGCACGUCUGCCAUGAAACTT 13489.6S86AGCCACUUGUGAACAUUGUTTACAAUGUUCACAAGUGGCUTT 13444.3S87GCCACUUGUGAACAUUGUGTTCACAAUGUUCACAAGUGGCTT 13459.4S88CAUUGUGGCACUGAAAAUUTTAAUUUUCAGUGCCACAAUGTT 13429.2S89AUUUAGUUAUUGAAGGACCTTGGUCCUUCAAUAACUAAAUTT 13414.1S90UUUAGUUAUUGAAGGACCUTTAGGUCCUUCAAUAACUAAATT 13414.1S91GGACCUACUACAUGUGGGUTTACCCACAUGUAGUAGGUCCTT 13474.5S92UGCUGUAGUGAAAAUGCCATTUGGCAUUUUCACUACAGCATT 13444.3S93AAUGCCAUGUCCUGCCUGUTTACAGGCAGGACAUGGCAUUTT 13474.5S94AUGCCAUGUCCUGCCUGUCTTGACAGGCAGGACAUGGCAUTT 13489.6S95UGCCAUGUCCUGCCUGUCATTUGACAGGCAGGACAUGGCATT 13489.6S96GACCCAGAGAUUGGACCUGTTCAGGUCCAAUCUCUGGGUCTT 13489.6S97CCACUCAAACAUUGAAACUTTAGUUUCAAUGUUUGAGUGGTT 13429.2S98ACAUUGAAACUCGACUCCGTTCGGAGUCGAGUUUCAAUGUTT 13459.4S99CAUUGAAACUCGACUCCGCTTGCGGAGUCGAGUUUCAAUGTT 13474.5S100 ACUCGACUCCGCAAGGGAGTTCUCCCUUGCGGAGUCGAGUTT 13504.7S101 CUCGACUCCGCAAGGGAGGTTCCUCCCUUGCGGAGUCGAGTT 13519.8S102 GGGAGGUAGGACUAGAUGUTTACAUCUAGUCCUACCUCCCTT 13474.5S103 UAAGCGUGCCUACUGGGUUTTAACCCAGUAGGCACGCUUATT 13474.5S104 GCGUGCCUACUGGGUUCCUTTAGGAACCCAGUAGGCACGCTT 13504.7
S105UGUGGAGACCUUGAAUGAGTT CUCAUUCAAGGUCUCCACATT 13459.4S106UGAGGAUCUCCUUGAGAUATT UAUCUCAAGGAGAUCCUCATT 13444.3S107CGUGUUAACAUUAACAUUGTT CAAUGUUAAUGUUAACACGTT 13414.1S108CAUUAACAUUGUUGGCGAUTT AUCGCCAACAAUGUUAAUGTT 13429.2S109CAUUGUUGGCGAUUUUCAUTT AUGAAAAUCGCCAACAAUGTT 13429.2S110UGAAGAGGUUGCCAUCAUUTT AAUGAUGGCAACCUCUUCATT 13444.3S111GAGGUUGCCAUCAUUUUGGTT CCAAAAUGAUGGCAACCUCTT 13459.4S112GUGCCUUUAUUGACACUAUTT AUAGUGUCAAUAAAGGCACTT 13429.2S113AGAGUCUUGAUUACAAGUCTT GACUUGUAAUCAAGACUCUTT 13429.2S114GAGUCUUGAUUACAAGUCUTT AGACUUGUAAUCAAGACUCTT 13429.2S115GUCUUUCAAAACCAUUGUUTT AACAAUGGUUUUGAAAGACTT 13414.1S116AACCAUUGUUGAGUCCUGCTT GCAGGACUCAACAAUGGUUTT 13459.4S117ACCAUUGUUGAGUCCUGCGTT CGCAGGACUCAACAAUGGUTT 13474.5S118CCAUUGUUGAGUCCUGCGGTT CCGCAGGACUCAACAAUGGTT 13489.6S119CUAUAAAGUUACCAAGGGATT UCCCUUGGUAACUUUAUAGTT 13429.2S120AGUUACCAAGGGAAAGCCCTT GGGCUUUCCCUUGGUAACUTT 13474.5S121GUUACCAAGGGAAAGCCCGTT CGGGCUUUCCCUUGGUAACTT 13489.6S122GGGAAAGCCCGUAAAAGGUTT ACCUUUUACGGGCUUUCCCTT 13474.5S123AGCCCGUAAAAGGUGCUUGTT CAAGCACCUUUUACGGGCUTT 13474.5S124GCCCGUAAAAGGUGCUUGGTT CCAAGCACCUUUUACGGGCTT 13489.6S125AAGGUGCUUGGAACAUUGGTT CCAAUGUUCCAAGCACCUUTT 13459.4S126AGGUGCUUGGAACAUUGGATT UCCAAUGUUCCAAGCACCUTT 13459.4S127GGUGCUUGGAACAUUGGACTT GUCCAAUGUUCCAAGCACCTT 13474.5S128CAUUGGACAACAGAGAUCATT UGAUCUCUGUUGUCCAAUGTT 13444.3S129CAGAGAUCAGUUUUAACACTT GUGUUAAAACUGAUCUCUGTT 13429.2S130CACCACUGUGUGGUUUUCCTT GGAAAACCACACAGUGGUGTT 13474.5S131UUUUUGCGCGCACACUUGATT UCAAGUGUGCGCGCAAAAATT 13459.4S132ACCACUCAAUUCCUGAUUUTT AAAUCAGGAAUUGAGUGGUTT 13429.2S133CCACUCAAUUCCUGAUUUGTT CAAAUCAGGAAUUGAGUGGTT 13444.3S134UUCCUGAUUUGCAAAGAGCTT GCUCUUUGCAAAUCAGGAATT 13444.3S135AGAGCAGCUGUCACCAUACTT GUAUGGUGACAGCUGCUCUTT 13474.5S136GAGCAGCUGUCACCAUACUTT AGUAUGGUGACAGCUGCUCTT 13474.5S137CAGUCAUUACGUCUUGUCGTT CGACAAGACGUAAUGACUGTT 13459.4S138CAGUGUCAUUAUUAUGGCATT UGCCAUAAUAAUGACACUGTT 13429.2
S139 CUGGUGGUCUUGUACAACATT UGUUGUACAAGACCACCAGTT 13459.4S140 CAGACUUCUCAGUGGUUGUTT ACAACCACUGAGAAGUCUGTT 13459.4S141 UCUUUUGGGCACUACUGUUTT AACAGUAGUGCCCAAAAGATT 13444.3S142 AAACUCAGGCCUAUCUUUGTT CAAAGAUAGGCCUGAGUUUTT 13444.3S143 AACUCAGGCCUAUCUUUGATT UCAAAGAUAGGCCUGAGUUTT 13444.3S144 ACUCAGGCCUAUCUUUGAATT UUCAAAGAUAGGCCUGAGUTT 13444.3S145 CUCAGGCCUAUCUUUGAAUTT AUUCAAAGAUAGGCCUGAGTT 13444.3S146 UGGAUUGAGGCGAAACUUATT UAAGUUUCGCCUCAAUCCATT 13444.3S147 ACUUAGUGCAGGAGUUGAATT UUCAACUCCUGCACUAAGUTT 13444.3S148 CUUAGUGCAGGAGUUGAAUTT AUUCAACUCCUGCACUAAGTT 13444.3S149 UUUCUCAAGGAUGCUUGGGTT CCCAAGCAUCCUUGAGAAATT 13459.4S150 GGAUGCUUGGGAGAUUCUCTT GAGAAUCUCCCAAGCAUCCTT 13474.5S151 AUUUCUCAUUACAGGUGUUTT AACACCUGUAAUGAGAAAUTT 13414.1S152 UUUCUCAUUACAGGUGUUUTT AAACACCUGUAAUGAGAAATT 13414.1S153 GGGUCAAAUACAGGUUGCUTT AGCAACCUGUAUUUGACCCTT 13459.4S154 AUACAGGUUGCUUCAGAUATT UAUCUGAAGCAACCUGUAUTT 13429.2S155 UACAGGUUGCUUCAGAUAATT UUAUCUGAAGCAACCUGUATT 13429.2S156 CAUCAAGGAUUGUGUAAAATT UUUUACACAAUCCUUGAUGTT 13414.1S157 GGAUUGUGUAAAAUGCUUCTT GAAGCAUUUUACACAAUCCTT 13429.2S158 AAUGCUUCAUUGAUGUUGUTT ACAACAUCAAUGAAGCAUUTT 13414.1S159 AUGCUUCAUUGAUGUUGUUTT AACAACAUCAAUGAAGCAUTT 13414.1S160 UGCUUCAUUGAUGUUGUUATT UAACAACAUCAAUGAAGCATT 13414.1S161 CAAGGCACUCGAAAUGUGCTT GCACAUUUCGAGUGCCUUGTT 13474.5S162 GGCACUCGAAAUGUGCAUUTT AAUGCACAUUUCGAGUGCCTT 13459.4S163 AUGUGCAUUGAUCAAGUCATT UGACUUGAUCAAUGCACAUTT 13429.2S164 UGUGCAUUGAUCAAGUCACTT GUGACUUGAUCAAUGCACATT 13444.3S165 GUCACUAUCGCUGGCGCAATT UUGCGCCAGCGAUAGUGACTT 13489.6S166 AGUUGCGAUCACUCAACUUTT AAGUUGAGUGAUCGCAACUTT 13444.3S167 GUUGCGAUCACUCAACUUATT UAAGUUGAGUGAUCGCAACTT 13444.3S168 CUUAGGUGAAGUCUUCAUCTT GAUGAAGACUUCACCUAAGTT 13444.3S169 GUCUUCAUCGCUCAAAGCATT UGCUUUGAGCGAUGAAGACTT 13459.4S170 AGCAAGGGACUUUACCGUCTT GACGGUAAAGUCCCUUGCUTT 13474.5S171 GCAAGGGACUUUACCGUCATT UGACGGUAAAGUCCCUUGCTT 13474.5S172 GGGACUUUACCGUCAGUGUTT ACACUGACGGUAAAGUCCCTT 13474.5
S173 GGAGCAGCUGCAACUACUCTTGAGUAGUUGCAGCUGCUCCTT 13489.6S174 CUACUCAUGCCUCUUAAGGTTCCUUAAGAGGCAUGAGUAGTT 13459.4S175 GGCACCAAAAGAAGUAACCTTGGUUACUUCUUUUGGUGCCTT 13459.4S176 AAGAAGUAACCUUUCUUGATTUCAAGAAAGGUUACUUCUUTT 13414.1S177 AGAAGUAACCUUUCUUGAATTUUCAAGAAAGGUUACUUCUTT 13414.1S178 GAAGUAACCUUUCUUGAAGTTCUUCAAGAAAGGUUACUUCTT 13429.2S179 GUAACCUUUCUUGAAGGUGTTCACCUUCAAGAAAGGUUACTT 13444.3S180 CCUUUCUUGAAGGUGAUUCTTGAAUCACCUUCAAGAAAGGTT 13444.3S181 GGUGAUUCACAUGACACAGTTCUGUGUCAUGUGAAUCACCTT 13459.4S182 GAACGGUGAACUCGAAGCATTUGCUUCGAGUUCACCGUUCTT 13474.5S183 CGGUGAACUCGAAGCACUCTTGAGUGCUUCGAGUUCACCGTT 13489.6S184 CUCGAAGCACUCGAGACGCTTGCGUCUCGAGUGCUUCGAGTT 13504.7S185 GCACUCGAGACGCCCGUUGTTCAACGGGCGUCUCGAGUGCTT 13519.8S186 AUGGAGCUAUCGUCGGCACTTGUGCCGACGAUAGCUCCAUTT 13489.6S187 UGGAGCUAUCGUCGGCACATTUGUGCCGACGAUAGCUCCATT 13489.6S188 AUGGCCUCAUGCUCUUAGATTUCUAAGAGCAUGAGGCCAUTT 13459.4S189 UGGCCUCAUGCUCUUAGAGTTCUCUAAGAGCAUGAGGCCATT 13474.5S190 GGACAAAGAACAAUACUGCTTGCAGUAUUGUUCUUUGUCCTT 13444.3S191 AGAACAAUACUGCGCAUUGTTCAAUGCGCAGUAUUGUUCUTT 13444.3S192 GAACAAUACUGCGCAUUGUTTACAAUGCGCAGUAUUGUUCTT 13444.3S193 CAAUACUGCGCAUUGUCUCTTGAGACAAUGCGCAGUAUUGTT 13459.4S194 UACUGCGCAUUGUCUCCUGTTCAGGAGACAAUGCGCAGUATT 13474.5S195 ACAAUGUCUUUCGCUUAAATTUUUAAGCGAAAGACAUUGUTT 13414.1S196 CAAUGUCUUUCGCUUAAAATTUUUUAAGCGAAAGACAUUGTT 13414.1S197 UGUCUUUCGCUUAAAAGGGTTCCCUUUUAAGCGAAAGACATT 13444.3S198 AAGGGGGUGCACCAAUUAATTUUAAUUGGUGCACCCCCUUTT 13459.4S199 AGGGGGUGCACCAAUUAAATTUUUAAUUGGUGCACCCCCUTT 13459.4S200 GGGGGUGCACCAAUUAAAGTTCUUUAAUUGGUGCACCCCCTT 13474.5S201 UUAAAGGUGUAACCUUUGGTTCCAAAGGUUACACCUUUAATT 13429.2S202 AGGUGUAACCUUUGGAGAATTUUCUCCAAAGGUUACACCUTT 13444.3S203 GGUGUAACCUUUGGAGAAGTTCUUCUCCAAAGGUUACACCTT 13459.4S204 CCUUUGGAGAAGAUACUGUTTACAGUAUCUUCUCCAAAGGTT 13444.3S205 GAUACUGUUUGGGAAGUUCTTGAACUUCCCAAACAGUAUCTT 13444.3S206 GUUCAAGGUUACAAGAAUGTTCAUUCUUGUAACCUUGAACTT 13429.2
S207 GGUUACAAGAAUGUGAGAATT UUCUCACAUUCUUGUAACCTT 13429.2S208 GAAUGUGAGAAUCACAUUUTT AAAUGUGAUUCUCACAUUCTT 13414.1S209 UGUGAGAAUCACAUUUGAGTT CUCAAAUGUGAUUCUCACATT 13429.2S210 UCACAUUUGAGCUUGAUGATT UCAUCAAGCUCAAAUGUGATT 13429.2S211 CGUGUUGACAAAGUGCUUATT UAAGCACUUUGUCAACACGTT 13444.3S212 AGUGCUUAAUGAAAAGUGCTT GCACUUUUCAUUAAGCACUTT 13429.2S213 GUGCUUAAUGAAAAGUGCUTT AGCACUUUUCAUUAAGCACTT 13429.2S214 UGAAAAGUGCUCUGUCUACTT GUAGACAGAGCACUUUUCATT 13444.3S215 AAGUGCUCUGUCUACACUGTT CAGUGUAGACAGAGCACUUTT 13459.4S216 AGUGCUCUGUCUACACUGUTT ACAGUGUAGACAGAGCACUTT 13459.4S217 GUGCUCUGUCUACACUGUUTT AACAGUGUAGACAGAGCACTT 13459.4S218 UCCGGUACCGAAGUUACUGTT CAGUAACUUCGGUACCGGATT 13474.5S219 GUUACUGAGUUUGCAUGUGTT CACAUGCAAACUCAGUAACTT 13444.3S220 GACUUUACAACCAGUUUCUTT AGAAACUGGUUGUAAAGUCTT 13429.2S221 CCAGUUUCUGAUCUCCUUATT UAAGGAGAUCAGAAACUGGTT 13444.3S222 CAUGGGUAUUGAUCUUGAUTT AUCAAGAUCAAUACCCAUGTT 13429.2S223 GAAAACUUUUCAUCACGUATT UACGUGAUGAAAAGUUUUCTT 13414.1S224 AACUUUUCAUCACGUAUGUTT ACAUACGUGAUGAAAAGUUTT 13414.1S225 ACUUUUCAUCACGUAUGUATT UACAUACGUGAUGAAAAGUTT 13414.1S226 CUUUUCAUCACGUAUGUAUTT AUACAUACGUGAUGAAAAGTT 13414.1S227 GAAGAGGACGAUGCAGAGUTT ACUCUGCAUCGUCCUCUUCTT 13474.5S228 GAGGACGAUGCAGAGUGUGTT CACACUCUGCAUCGUCCUCTT 13489.6S229 GAAGAAAUUGAUGAAACCUTT AGGUUUCAUCAAUUUCUUCTT 13414.1S230 GAAAUUGAUGAAACCUGUGTT CACAGGUUUCAUCAAUUUCTT 13429.2S231 AUUGAUGAAACCUGUGAACTT GUUCACAGGUUUCAUCAAUTT 13429.2S232 UUGAUGAAACCUGUGAACATT UGUUCACAGGUUUCAUCAATT 13429.2S233 ACCUGUGAACAUGAGUACGTT CGUACUCAUGUUCACAGGUTT 13459.4S234 CCUGUGAACAUGAGUACGGTT CCGUACUCAUGUUCACAGGTT 13474.5S235 CAUGAGUACGGUACAGAGGTT CCUCUGUACCGUACUCAUGTT 13474.5S236 GGUCUCCCUCUGGAAUUUGTT CAAAUUCCAGAGGGAGACCTT 13474.5S237 UUUGGUGCCUCAGCUGAAATT UUUCAGCUGAGGCACCAAATT 13459.4S238 ACAGUUCGAGUUGAGGAAGTT CUUCCUCAACUCGAACUGUTT 13459.4S239 CAGUUCGAGUUGAGGAAGATT UCUUCCUCAACUCGAACUGTT 13459.4S240 GAAGAAGAGGAAGACUGGCTT GCCAGUCUUCCUCUUCUUCTT 13474.5
S241GAAGAGGAAGACUGGCUGGTT CCAGCCAGUCUUCCUCUUCTT 13489.6S242GAGGAAGACUGGCUGGAUGTT CAUCCAGCCAGUCUUCCUCTT 13489.6S243GACUGGCUGGAUGAUACUATT UAGUAUCAUCCAGCCAGUCTT 13459.4S244UCAGAGAUUGAGCCAGAACTT GUUCUGGCUCAAUCUCUGATT 13459.4S245CCAGAACCUACACCUGAAGTT CUUCAGGUGUAGGUUCUGGTT 13474.5S246CCUACACCUGAAGAACCAGTT CUGGUUCUUCAGGUGUAGGTT 13474.5S247GAACCAGUUAAUCAGUUUATT UAAACUGAUUAACUGGUUCTT 13414.1S248CCAGUUAAUCAGUUUACUGTT CAGUAAACUGAUUAACUGGTT 13429.2S249AACUUACUGACAAUGUUGCTT GCAACAUUGUCAGUAAGUUTT 13429.2S250ACUUACUGACAAUGUUGCCTT GGCAACAUUGUCAGUAAGUTT 13444.3S251CUUACUGACAAUGUUGCCATT UGGCAACAUUGUCAGUAAGTT 13444.3S252UGUUGCCAUUAAAUGUGUUTT AACACAUUUAAUGGCAACATT 13414.1S253AUGUGUUGACAUCGUUAAGTT CUUAACGAUGUCAACACAUTT 13429.2S254UGUGUUGACAUCGUUAAGGTT CCUUAACGAUGUCAACACATT 13444.3S255GGAGGCACAAAGUGCUAAUTT AUUAGCACUUUGUGCCUCCTT 13459.4S256AGUGCUAAUCCUAUGGUGATT UCACCAUAGGAUUAGCACUTT 13444.3S257GUGCUAAUCCUAUGGUGAUTT AUCACCAUAGGAUUAGCACTT 13444.3S258UCCUAUGGUGAUUGUAAAUTT AUUUACAAUCACCAUAGGATT 13414.1S259AUGCUGCUAACAUACACCUTT AGGUGUAUGUUAGCAGCAUTT 13444.3S260UGCUGCUAACAUACACCUGTT CAGGUGUAUGUUAGCAGCATT 13459.4S261CAUACACCUGAAACAUGGUTT ACCAUGUUUCAGGUGUAUGTT 13444.3S262ACAUGGUGGUGGUGUAGCATT UGCUACACCACCACCAUGUTT 13474.5S263CAUGGUGGUGGUGUAGCAGTT CUGCUACACCACCACCAUGTT 13489.6S264CAAGGCAACCAAUGGUGCCTT GGCACCAUUGGUUGCCUUGTT 13489.6S265GGCAACCAAUGGUGCCAUGTT CAUGGCACCAUUGGUUGCCTT 13489.6S266CCAAUGGUGCCAUGCAAAATT UUUUGCAUGGCACCAUUGGTT 13459.4S267UGGUGCCAUGCAAAAGGAGTT CUCCUUUUGCAUGGCACCATT 13474.5S268AAGGAGAGUGAUGAUUACATT UGUAAUCAUCACUCUCCUUTT 13429.2S269AGGAGAGUGAUGAUUACAUTT AUGUAAUCAUCACUCUCCUTT 13429.2S270GGAGAGUGAUGAUUACAUUTT AAUGUAAUCAUCACUCUCCTT 13429.2S271GCUAAAUGGCCCUCUUACATT UGUAAGAGGGCCAUUUAGCTT 13459.4S272AUGGCCCUCUUACAGUAGGTT CCUACUGUAAGAGGGCCAUTT 13474.5S273UGGCCCUCUUACAGUAGGATT UCCUACUGUAAGAGGGCCATT 13474.5S274UCUUGCUAAGAAGUGUCUGTT CAGACACUUCUUAGCAAGATT 13444.3
S275 GAAGUGUCUGCAUGUUGUUTT AACAACAUGCAGACACUUCTT 13444.3S276 GUGUCUGCAUGUUGUUGGATT UCCAACAACAUGCAGACACTT 13459.4S277 CCUAAAUGCAGGUGAGGACTT GUCCUCACCUGCAUUUAGGTT 13474.5S278 AUGCAGGUGAGGACAUCCATT UGGAUGUCCUCACCUGCAUTT 13474.5S279 UGCAGGUGAGGACAUCCAGTT CUGGAUGUCCUCACCUGCATT 13489.6S280 GGCAGCAUAUGAAAAUUUCTT GAAAUUUUCAUAUGCUGCCTT 13429.2S281 AAUUUCAAUUCACAGGACATT UGUCCUGUGAAUUGAAAUUTT 13414.1S282 AUUUCAAUUCACAGGACAUTT AUGUCCUGUGAAUUGAAAUTT 13414.1S283 UUUCAAUUCACAGGACAUCTT GAUGUCCUGUGAAUUGAAATT 13429.2S284 UUCACAGGACAUCUUACUUTT AAGUAAGAUGUCCUGUGAATT 13429.2S285 ACCACUUCAGUCUUUACAATT UUGUAAAGACUGAAGUGGUTT 13429.2S286 GUGUGCGUGCAGACGGUUCTT GAACCGUCUGCACGCACACTT 13504.7S287 UGACAAAGCUCUUUAUGAGTT CUCAUAAAGAGCUUUGUCATT 13429.2S288 AGCUCUUUAUGAGCAGGUUTT AACCUGCUCAUAAAGAGCUTT 13444.3S289 GCUCUUUAUGAGCAGGUUGTT CAACCUGCUCAUAAAGAGCTT 13459.4S290 CCUGAAGCCUAGAGUGGAATT UUCCACUCUAGGCUUCAGGTT 13474.5S291 GCCUAGAGUGGAAGCACCUTT AGGUGCUUCCACUCUAGGCTT 13489.6S292 GCACCUAAACAAGAGGAGCTT GCUCCUCUUGUUUAGGUGCTT 13474.5S293 ACAAGAGGAGCCACCAAACTT GUUUGGUGGCUCCUCUUGUTT 13474.5S294 CAAGAGGAGCCACCAAACATT UGUUUGGUGGCUCCUCUUGTT 13474.5S295 GAGGAGCCACCAAACACAGTT CUGUGUUUGGUGGCUCCUCTT 13489.6S296 ACACAGAAGAUUCCAAAACTT GUUUUGGAAUCUUCUGUGUTT 13429.2S297 CACAGAAGAUUCCAAAACUTT AGUUUUGGAAUCUUCUGUGTT 13429.2S298 GAUUCCAAAACUGAGGAGATT UCUCCUCAGUUUUGGAAUCTT 13444.3S299 AACUGAGGAGAAAUCUGUCTT GACAGAUUUCUCCUCAGUUTT 13444.3S300 ACUGAGGAGAAAUCUGUCGTT CGACAGAUUUCUCCUCAGUTT 13459.4S301 CUGAGGAGAAAUCUGUCGUTT ACGACAGAUUUCUCCUCAGTT 13459.4S302 AUCUGUCGUACAGAAGCCUTT AGGCUUCUGUACGACAGAUTT 13459.4S303 UCUGUCGUACAGAAGCCUGTT CAGGCUUCUGUACGACAGATT 13474.5S304 GCCUGUCGAUGUGAAGCCATT UGGCUUCACAUCGACAGGCTT 13489.6S305 GCCAAAAAUUAAGGCCUGCTT GCAGGCCUUAAUUUUUGGCTT 13459.4S306 AAAUUAAGGCCUGCAUUGATT UCAAUGCAGGCCUUAAUUUTT 13429.2S307 AAUUAAGGCCUGCAUUGAUTT AUCAAUGGAGGCCUUAAUUTT 13429.2S308 AUUAAGGCCUGCAUUGAUGTT CAUCAAUGCAGGCCUUAAUTT 13444.3
S309 UUAAGGCCUGCAUUGAUGATT UCAUCAAUGCAGGCCUUAATT 13444.3S310 GGCCUGCAUUGAUGAGGUUTT AACCUCAUCAAUGCAGGCCTT 13474.5S311 CACUGGAAGAAACUAAGUUTT AACUUAGUUUCUUCCAGUGTT 13429.2S312 GAAACUAAGUUUCUUACCATT UGGUAAGAAACUUAGUUUCTT 13414.1S313 UAAGUUACUCUUGUUUGCUTT AGCAAACAAGAGUAACUUATT 13414.1S314 GUUACUCUUGUUUGCUGAUTT AUCAGCAAACAAGAGUAACTT 13429.2S315 UGGUAAGCUUUACCAUGAUTT AUCAUGGUAAAGCUUACCATT 13429.2S316 GCUUUACCAUGAUUCUCAGTT CUGAGAAUCAUGGUAAAGCTT 13444.3S317 CAUGCUUAGAGGUGAAGAUTT AUCUUCACCUCUAAGCAUGTT 13444.3S318 GAUAUGUCUUUCCUUGAGATT UCUCAAGGAAAGACAUAUCTT 13429.2S319 GGAUGCACCUUACAUGGUATT UACCAUGUAAGGUGCAUCCTT 13459.4S320 UACCCUCCAAAAAGGCUGGTT CCAGCCUUUUUGGAGGGUATT 13474.5S321 AAAGGCUGGUGGCACUACUTT AGUAGUGCCACCAGCCUUUTT 13474.5S322 AAGGCUGGUGGCACUACUGTT CAGUAGUGCCACCAGCCUUTT 13489.6S323 AGGCUGGUGGCACUACUGATT UCAGUAGUGCCACCAGCCUTT 13489.6S324 GGCUGGUGGCACUACUGAGTT CUCAGUAGUGCCACCAGCCTT 13504.7S325 GAGCUUUGAAGAAAGUGCCTT GGCACUUUCUUCAAAGCUCTT 13459.4S326 AGUGCCAGUUGAUGAGUAUTT AUACUCAUCAACUGGCACUTT 13444.3S327 GUGCCAGUUGAUGAGUAUATT UAUACUCAUCAACUGGCACTT 13444.3S328 CCACGUACCCUGGACAAGGTT CCUUGUCCAGGGUACGUGGTT 13504.7S329 GGAUGUGCUGGUUAUACACTT GUGUAUAACCAGCACAUCCTT 13459.4S330 GCUAAGACUGCUCUUAAGATT UCUUAAGAGCAGUCUUAGCTT 13444.3S331 GACUGCUCUUAAGAAAUGCTT GCAUUUCUUAAGAGCAGUCTT 13444.3S332 GAAAUGCAAAUCUGCAUUUTT AAAUGCAGAUUUGCAUUUCTT 13414.1S333 UGCAAAUCUGCAUUUUAUGTT CAUAAAAUGCAGAUUUGCATT 13414.1S334 UCUGCAUUUUAUGUACUACTT GUAGUACAUAAAAUGCAGATT 13414.1S335 GCACCUAAUGCUAAGGAAGTT CUUCCUUAGCAUUAGGUGCTT 13459.4S336 UGCUAAGGAAGAGAUUCUATT UAGAAUCUCUUCCUUAGCATT 13429.2S337 GGAAGAGAUUCUAGGAACUTT AGUUCCUAGAAUCUCUUCCTT 13444.3S338 GAGAUUCUAGGAACUGUAUTT AUACAGUUCCUAGAAUCUCTT 13429.2S339 CUGUAUCCUGGAAUUUGAGTT CUCAAAUUCCAGGAUACAGTT 13444.3S340 UUUGAGAGAAAUGCUUGCUTT AGCAAGCAUUUCUCUCAAATT 13429.2S341 AUGCUUGCUCAUGCUGAAGTT CUUCAGCAUGAGCAAGCAUTT 13459.4S342 UGCUUGCUCAUGCUGAAGATT UCUUCAGCAUGAGCAAGCATT 13459.4
S343 GAGACAAGAAAAUUAAUGCTT GCAUUAAUUUUCUUGUCUCTT 13414.1S344 AUUAAUGCCUAUAUGCAUGTT CAUGCAUAUAGGCAUUAAUTT 13414.1S345 UUAAUGCCUAUAUGCAUGGTT CCAUGCAUAUAGGCAUUAATT 13429.2S346 UGCCUAUAUGCAUGGAUGUTT ACAUCCAUGCAUAUAGGCATT 13444.3S347 UGGCAACCAUCCAACGUAATT UUACGUUGGAUGGUUGCCATT 13459.4S348 CCAUCCAACGUAAGUAUAATT UUAUACUUACGUUGGAUGGTT 13429.2S349 GGAAUUAAAAUUCAAGAGGTT CCUCUUGAAUUUUAAUUCCTT 13414.1S350 UUAAAAUUCAAGAGGGCAUTT AUGCCCUCUUGAAUUUUAATT 13414.1S351 AAUUCAAGAGGGCAUCGUUTT AACGAUGCCCUCUUGAAUUTT 13444.3S352 AUUCAAGAGGGCAUCGUUGTT CAACGAUGCCCUCUUGAAUTT 13459.4S353 UUCAAGAGGGCAUCGUUGATT UCAACGAUGCCCUCUUGAATT 13459.4S354 GAGGGCAUCGUUGACUAUGTT CAUAGUCAACGAUGCCCUCTT 13474.5S355 AGAGCCUGUAGCUUCUAUUTT AAUAGAAGCUACAGGCUCUTT 13444.3S356 GAGCCUGUAGCUUCUAUUATT UAAUAGAAGCUACAGGCUCTT 13444.3S357 GCUGAACUCUCUAAAUGAGTT CUCAUUUAGAGAGUUCAGCTT 13444.3S358 CUCUCUAAAUGAGCCGCUUTT AAGCGGCUCAUUUAGAGAGTT 13459.4S359 AUGAGCCGCUUGUCACAAUTT AUUGUGACAAGCGGCUCAUTT 13459.4S360 UGAGCCGCUUGUCACAAUGTT CAUUGUGACAAGCGGCUCATT 13474.5S361 UGCCAAUUGGUUAUGUGACTT GUCACAUAACCAAUUGGCATT 13444.3S362 UUGGUUAUGUGACACAUGGTT CCAUGUGUCACAUAACCAATT 13444.3S363 UCUUGAAGAGGCUGCGCGCTT GCGCGCAGCCUCUUCAAGATT 13504.7S364 GAGGCUGCGCGCUGUAUGCTT GCAUACAGCGCGCAGCCUCTT 13519.8S365 AGCUCCUGCCGUAGUGUCATT UGACACUACGGCAGGAGCUTT 13489.6S366 GCUCCUGCCGUAGUGUCAGTT CUGACACUACGGCAGGAGCTT 13504.7S367 UGGAUACCUCACUUCGUCATT UGACGAAGUGAGGUAUCCATT 13459.4S368 AGACAUCUGAGGAGCACUUTT AAGUGCUCCUCAGAUGUCUTT 13459.4S369 GACAUCUGAGGAGCACUUUTT AAAGUGCUCCUCAGAUGUCTT 13459.4S370 ACAGUUUCUUUGGCUGGCUTT AGCCAGCCAAAGAAACUGUTT 13459.4S371 CAGUUUCUUUGGCUGGCUCTT GAGCCAGCCAAAGAAACUGTT 13474.5S372 UUUCUUAAGCGUGGUGACATT UGUCACCACGCUUAAGAAATT 13444.3S373 GCGUGGUGACAAAAUUGUGTT CACAAUUUUGUCACCACGCTT 13459.4S374 AAUUGUGUACCACACUCUGTT CAGAGUGUGGUACACAAUUTT 13444.3S375 AUUGUGUACCACACUCUGGTT CCAGAGUGUGGUACACAAUTT 13459.4S376 UUGUGUACCACACUCUGGATT UCCAGAGUGUGGUACACAATT 13459.4
S377 ACUAAAGAGUCUCUUAUCCTT GGAUAAGAGACUCUUUAGUTT 13429.2S378 CUAAAGAGUCUCUUAUCCCTT GGGAUAAGAGACUCUUUAGTT 13444.3S379 AGAGUCUCUUAUCCCUGCGTT CGCAGGGAUAAGAGACUCUTT 13474.5S380 GAGUCUCUUAUCCCUGCGGTT CCGCAGGGAUAAGAGACUCTT 13489.6S381 GACUAUAAAAGUGUUCACATT UGUGAACACUUUUAUAGUCTT 13414.1S382 AAGUGUUCACAACUGUGGATT UCCACAGUUGUGAACACUUTT 13444.3S383 AGUGUUCACAACUGUGGACTT GUCCACAGUUGUGAACACUTT 13459.4S384 GUGUUCACAACUGUGGACATT UGUCCACAGUUGUGAACACTT 13459.4S385 CUGUGGACAACACUAAUCUTT AGAUUAGUGUUGUCCACAGTT 13444.3S386 CACUAAUCUCCACACACAGTT CUGUGUGUGGAGAUUAGUGTT 13459.4S387 UCUCCACACACAGCUUGUGTT CACAAGCUGUGUGUGGAGATT 13474.5S388 CAUACUUGGAUGGUGCUGATT UCAGCACCAUCCAAGUAUGTT 13459.4S389 ACCUCAUGUAAAUCAUGAGTT CUCAUGAUUUACAUGAGGUTT 13429.2S390 CCUCAUGUAAAUCAUGAGGTT CCUCAUGAUUUACAUGAGGTT 13444.3S391 AUCAUGAGGGUAAGACUUUTT AAAGUCUUACCCUCAUGAUTT 13429.2S392 UCAUGAGGGUAAGACUUUCTT GAAAGUCUUACCCUCAUGATT 13444.3S393 GACUUUCUUUGUACUACCUTT AGGUAGUACAAAGAAAGUCTT 13429.2S394 GCUUUCGAGUACUACCAUATT UAUGGUAGUACUCGAAAGCTT 13444.3S395 CCACACAAAGAAAUGGAAATT UUUCCAUUUCUUUGUGUGGTT 13429.2S396 AGAAAUGGAAAUUUCCUCATT UGAGGAAAUUUCCAUUUCUTT 13414.1S397 GAAAUGGAAAUUUCCUCAATT UUGAGGAAAUUUCCAUUUCTT 13414.1S398 AUGGAAAUUUCCUCAAGUUTT AACUUGAGGAAAUUUCCAUTT 13414.1S399 UGGAAAUUUCCUCAAGUUGTT CAACUUGAGGAAAUUUCCATT 13429.2S400 AUUUCCUCAAGUUGGUGGUTT ACCACCAACUUGAGGAAAUTT 13444.3S401 UUUCCUCAAGUUGGUGGUUTT AACCACCAACUUGAGGAAATT 13444.3S402 GUUGGUGGUUUAACUUCAATT UUGAAGUUAAACCACCAACTT 13429.2S403 CUUCAAUUAAAUGGGCUGATT UCAGCCCAUUUAAUUGAAGTT 13429.2S404 UUAAAUGGGCUGAUAACAATT UUGUUAUCAGCCCAUUUAATT 13414.1S405 AUGGGCUGAUAACAAUUGUTT ACAAUUGUUAUCAGCCCAUTT 13429.2S406 UGGGCUGAUAACAAUUGUUTT AACAAUUGUUAUCAGCCCATT 13429.2S407 CAGCUUGAAGUCAAAUUCATT UGAAUUUGACUUCAAGCUGTT 13429.2S408 GUCAAAUUCAAUGCACCAGTT CUGGUGCAUUGAAUUUGACTT 13444.3S409 AUUCAAUGCACCAGCACUUTT AAGUGCUGGUGCAUUGAAUTT 13444.3S410 UUCAAUGCACCAGCACUUCTT GAAGUGCUGGUGCAUUGAATT 13459.4
S411 UGCACCAGCACUUCAAGAGTT CUCUUGAAGUGCUGGUGCATT 13474.5S412 GAGGCUUAUUAUAGAGCCCTT GGGCUCUAUAAUAAGCCUCTT 13459.4S413 CUUUUGUGCACUCAUACUCTT GAGUAUGAGUGCACAAAAGTT 13444.3S414 UAAAACUGUUGGCGAGCUUTT AAGCUCGCCAACAGUUUUATT 13444.3S415 AACUGUUGGCGAGCUUGGUTT ACCAAGCUCGCCAACAGUUTT 13474.5S416 ACUGUUGGCGAGCUUGGUGTT CACCAAGCUCGCCAACAGUTT 13489.6S417 CUGUUGGCGAGCUUGGUGATT UCACCAAGCUCGCCAACAGTT 13489.6S418 ACUAUGACCCAUCUUCUACTT GUAGAAGAUGGGUCAUAGUTT 13444.3S419 CUAUGACCCAUCUUCUACATT UGUAGAAGAUGGGUCAUAGTT 13444.3S420 UUUGGAAUCUGCAAAGCGATT UCGCUUUGCAGAUUCCAAATT 13444.3S421 UCUGCAAAGCGAGUUCUUATT UAAGAACUCGCUUUGCAGATT 13444.3S422 AGCGAGUUCUUAAUGUGGUTT ACCACAUUAAGAACUCGCUTT 13444.3S423 GCGAGUUCUUAAUGUGGUGTT CACCACAUUAAGAACUCGCTT 13459.4S424 UGUGGUGUGUAAACAUUGUTT ACAAUGUUUACACACCACATT 13429.2S425 ACAUUGUGGUCAGAAAACUTT AGUUUUCUGACCACAAUGUTT 13429.2S426 CAUUGUGGUCAGAAAACUATT UAGUUUUCUGACCACAAUGTT 13429.2S427 AACUACUACCUUAACGGGUTT ACCCGUUAAGGUAGUAGUUTT 13444.3S428 ACUACUACCUUAACGGGUGTT CACCCGUUAAGGUAGUAGUTT 13459.4S429 CUACUACCUUAACGGGUGUTT ACACCCGUUAAGGUAGUAGTT 13459.4S430 CGGGUGUAGAAGCUGUGAUTT AUCACAGCUUCUACACCCGTT 13474.5S431 GCUGUGAUGUAUAUGGGUATT UACCCAUAUACAUCACAGCTT 13444.3S432 UCUUAAGACAGGUGUUUCCTT GGAAACACCUGUCUUAAGATT 13444.3S433 GACAGGUGUUUCCAUUCCATT UGGAAUGGAAACACCUGUCTT 13459.4S434 UAUCUAGUACAACAAGAGUTT ACUCUUGUUGUACUAGAUATT 13414.1S435 CAAGAGUCUUCUUUUGUUATT UAACAAAAGAAGACUCUUGTT 13414.1S436 GAGUCUUCUUUUGUUAUGATT UCAUAACAAAAGAAGACUCTT 13414.1S437 AUUACAGCAAGGUACAUUCTT GAAUGUACCUUGCUGUAAUTT 13429.2S438 UUACAGCAAGGUACAUUCUTT AGAAUGUACCUUGCUGUAATT 13429.2S439 GGUACAUUCUUAUGUGCGATT UCGCACAUAAGAAUGUACCTT 13444.3S440 UGAGUACACUGGUAACUAUTT AUAGUUACCAGUGUACUCATT 13429.2S441 CUAUCAGUGUGGUCAUUACTT GUAAUGACCACACUGAUAGTT 13444.3S442 CUGCUAAGGAGACCCUCUATT UAGAGGGUCUCCUUAGCAGTT 13474.5S443 GGAGACCCUCUAUCGUAUUTT AAUACGAUAGAGGGUCUCCTT 13459.4S444 AGAUGUCAGAGUACAAAGGTT CCUUUGUACUCUGACAUCUTT 13444.3
S445 GAUGUCAGAGUACAAAGGATT UCCUUUGUACUCUGACAUCTT 13444.3S446 AGGACCAGUGACUGAUGUUTT AACAUCAGUCACUGGUCCUTT 13459.4S447 GGACCAGUGACUGAUGUUUTT AAACAUCAGUCACUGGUCCTT 13459.4S448 GGAAACAUCUUACACUACATT UGUAGUGUAAGAUGUUUCCTT 13429.2S449 ACAUCUUACACUACAACCATT UGGUUGUAGUGUAAGAUGUTT 13429.2S450 CAUCUUACACUACAACCAUTT AUGGUUGUAGUGUAAGAUGTT 13429.2S451 CCAUCAAGCCUGUGUCGUATT UACGACACAGGCUUGAUGGTT 13474.5S452 GCCUGUGUCGUAUAAACUCTT GAGUUUAUACGACACAGGCTT 13459.4S453 ACUCGAUGGAGUUACUUACTT GUAAGUAACUCCAUCGAGUTT 13444.3S454 CUCGAUGGAGUUACUUACATT UGUAAGUAACUCCAUCGAGTT 13444.3S455 CCAAAAUUGGAUGGGUAUUTT AAUACCCAUCCAAUUUUGGTT 13429.2S456 AGGAUAAUGCUUACUAUACTT GUAUAGUAAGCAUUAUCCUTT 13414.1S457 GGAUAAUGCUUACUAUACATT UGUAUAGUAAGCAUUAUCCTT 13414.1S458 UGCUUACUAUACAGAGCAGTT CUGCUCUGUAUAGUAAGCATT 13444.3S459 CUCAACCAUUACCAAAUGCTT GCAUUUGGUAAUGGUUGAGTT 13444.3S460 CCAUUACCAAAUGCGAGUUTT AACUCGCAUUUGGUAAUGGTT 13444.3S461 UGCGAGUUUUGAUAAUUUCTT GAAAUUAUCAAAACUCGCATT 13414.1S462 UUUCAAACUCACAUGUUCUTT AGAACAUGUGAGUUUGAAATT 13414.1S463 ACUCACAUGUUCUAACACATT UGUGUUAGAACAUGUGAGUTT 13429.2S464 CUCACAUGUUCUAACACAATT UUGUGUUAGAACAUGUGAGTT 13429.2S465 CACAAAAUUUGCUGAUGAUTT AUCAUCAGCAAAUUUUGUGTT 13414.1S466 AUCAAAUGACAGGCUUCACTT GUGAAGCCUGUCAUUUGAUTT 13444.3S467 UCAAAUGACAGGCUUCACATT UGUGAAGCCUGUCAUUUGATT 13444.3S468 AUGACAGGCUUCACAAAGCTT GCUUUGUGAAGCCUGUCAUTT 13459.4S469 UGACAGGCUUCACAAAGCCTT GGCUUUGUGAAGCCUGUCATT 13474.5S470 AGCCAGCUUCACGAGAGCUTT AGCUCUCGUGAAGCUGGCUTT 13489.6S471 GCCAGCUUCACGAGAGCUATT UAGCUCUCGUGAAGCUGGCTT 13489.6S472 UGGCGAUGUAGUGGCUAUUTT AAUAGCCACUACAUCGCCATT 13459.4S473 GAAAGGUGCUAAAUUACUGTT CAGUAAUUUAGCACCUUUCTT 13429.2S474 AGGUGCUAAAUUACUGCAUTT AUGCAGUAAUUUAGCACCUTT 13429.2S475 GGUGCUAAAUUACUGCAUATT UAUGCAGUAAUUUAGCACCTT 13429.2S476 AUUACUGCAUAAGCCAAUUTT AAUUGGCUUAUGCAGUAAUTT 13414.1S477 UUACUGCAUAAGCCAAUUGTT CAAUUGGCUUAUGCAGUAATT 13429.2S478 GCCAAUUGUUUGGCACAUUTT AAUGUGCCAAACAAUUGGCTT 13444.3
S479 UUGUUUGGCACAUUAACCATT UGGUUAAUGUGCCAAACAATT 13429.2S480 CCAGGCUACAACCAAGACATT UGUCUUGGUUGUAGCCUGGTT 13474.5S481 CCAAGACAACGUUCAAACCTT GGUUUGAACGUUGUCUUGGTT 13459.4S482 GACAACGUUCAAACCAAACTT GUUUGGUUUGAACGUUGUCTT 13444.3S483 CGUUCAAACCAAACACUUGTT CAAGUGUUUGGUUUGAACGTT 13444.3S484 ACCAAACACUUGGUGUUUATT UAAACACCAAGUGUUUGGUTT 13429.2S485 CCAAACACUUGGUGUUUACTT GUAAACACCAAGUGUUUGGTT 13444.3S486 ACACUUGGUGUUUACGUUGTT CAACGUAAACACCAAGUGUTT 13444.3S487 CACUUGGUGUUUACGUUGUTT ACAACGUAAACACCAAGUGTT 13444.3S488 AGCCAGUAGAUACUUCAAATT UUUGAAGUAUCUACUGGCUTT 13429.2S489 GCCAGUAGAUACUUCAAAUTT AUUUGAAGUAUCUACUGGCTT 13429.2S490 AUUCAUUUGAAGUUCUGGCTT GCCAGAACUUCAAAUGAAUTT 13429.2S491 UUCAUUUGAAGUUCUGGCATT UGCCAGAACUUCAAAUGAATT 13429.2S492 GUUCUGGCAGUAGAAGACATT UGUCUUCUACUGCCAGAACTT 13459.4S493 GACACACAAGGAAUGGACATT UGUCCAUUCCUUGUGUGUCTT 13459.4S494 GGAAUGGACAAUCUUGCUUTT AAGCAAGAUUGUCCAUUCCTT 13444.3S495 UGGACAAUCUUGCUUGUGATT UCACAAGCAAGAUUGUCCATT 13444.3S496 UCUUGCUUGUGAAAGUCAATT UUGACUUUCACAAGCAAGATT 13429.2S497 AGUCAACAACCCACCUCUGTT CAGAGGUGGGUUGUUGACUTT 13474.5S498 GUCAACAACCCACCUCUGATT UCAGAGGUGGGUUGUUGACTT 13474.5S499 CAACCCACCUCUGAAGAAGTT CUUCUUCAGAGGUGGGUUGTT 13474.5S500 CCCACCUCUGAAGAAGUAGTT CUACUUCUUCAGAGGUGGGTT 13474.5S501 GAAGUAGUGGAAAAUCCUATT UAGGAUUUUCCACUACUUCTT 13429.2S502 GUAGUGGAAAAUCCUACCATT UGGUAGGAUUUUCCACUACTT 13444.3S503 AAUCCUACCAUACAGAAGGTT CCUUCUGUAUGGUAGGAUUTT 13444.3S504 AUCCUACCAUACAGAAGGATT UCCUUCUGUAUGGUAGGAUTT 13444.3S505 UCCUACCAUACAGAAGGAATT UUCCUUCUGUAUGGUAGGATT 13444.3S506 GGAAGUCAUAGAGUGUGACTT GUCACACUCUAUGACUUCCTT 13459.4S507 GUCAUAGAGUGUGACGUGATT UCACGUCACACUCUAUGACTT 13459.4S508 AACUACCGAAGUUGUAGGCTT GCCUACAACUUCGGUAGUUTT 13459.4S509 ACUACCGAAGUUGUAGGCATT UGCCUACAACUUCGGUAGUTT 13459.4S510 CUACCGAAGUUGUAGGCAATT UUGCCUACAACUUCGGUAGTT 13459.4S511 GUUGUAGGCAAUGUCAUACTT GUAUGACAUUGCCUACAACTT 13444.3S512 UGUCAUACUUAAACCAUCATT UGAUGGUUUAAGUAUGACATT 13414.1
S513 ACCAUCAGAUGAAGGUGUUTT AACACCUUCAUCUGAUGGUTT 13444.3S514 CCAUCAGAUGAAGGUGUUATT UAACACCUUCAUCUGAUGGTT 13444.3S515 GGUGUUAAAGUAACACAAGTT CUUGUGUUACUUUAACACCTT 13429.2S516 AGUAACACAAGAGUUAGGUTT ACCUAACUCUUGUGUUACUTT 13429.2S517 GUAACACAAGAGUUAGGUCTT GACCUAACUCUUGUGUUACTT 13444.3S518 CACAAGAGUUAGGUCAUGATT UCAUGACCUAACUCUUGUGTT 13444.3S519 GAGUUAGGUCAUGAGGAUCTT GAUCCUCAUGACCUAACUCTT 13459.4S520 AACACAAGCAUUACCAUUATT UAAUGGUAAUGCUUGUGUUTT 13414.1S521 ACACAAGCAUUACCAUUAATT UUAAUGGUAAUGCUUGUGUTT 13414.1S522 CACAAGCAUUACCAUUAAGTT CUUAAUGGUAAUGCUUGUGTT 13429.2S523 GCAUUACCAUUAAGAAACCTT GGUUUCUUAAUGGUAAUGCTT 13429.2S524 GAAACCUAAUGAGCUUUCATT UGAAAGCUCAUUAGGUUUCTT 13429.2S525 ACCUAAUGAGCUUUCACUATT UAGUGAAAGCUCAUUAGGUTT 13429.2S526 CCUAAUGAGCUUUCACUAGTT CUAGUGAAAGCUCAUUAGGTT 13444.3S527 UGAGCUUUCACUAGCCUUATT UAAGGCUAGUGAAAGCUCATT 13444.3S528 AAACAAUUGCCACUCAUGGTT CCAUGAGUGGCAAUUGUUUTT 13444.3S529 AACAAUUGCCACUCAUGGUTT ACCAUGAGUGGCAAUUGUUTT 13444.3S530 ACAAUUGCCACUCAUGGUATT UACCAUGAGUGGCAAUUGUTT 13444.3S531 CAAUUGCCACUCAUGGUAUTT AUACCAUGAGUGGCAAUUGTT 13444.3S532 UUGCCACUCAUGGUAUUGCTT GCAAUACCAUGAGUGGCAATT 13459.4S533 UUAAUAGUGUUCCUUGGAGTT CUCCAAGGAACACUAUUAATT 13429.2S534 UAGUGUUCCUUGGAGUAAATT UUUACUCCAAGGAACACUATT 13429.2S535 AUUUUGGCUUAUGUCAAACTT GUUUGACAUAAGCCAAAAUTT 13414.1S536 UUUUGGCUUAUGUCAAACCTT GGUUUGACAUAAGCCAAAATT 13429.2S537 ACCAUUCUUAGGACAAGCATT UGCUUGUCCUAAGAAUGGUTT 13444.3S538 CCAUUCUUAGGACAAGCAGTT CUGCUUGUCCUAAGAAUGGTT 13459.4S539 GCAGCAAUUACAACAUCAATT UUGAUGUUGUAAUUGCUGCTT 13429.2S540 UUACAACAUCAAAUUGCGCTT GCGCAAUUUGAUGUUGUAATT 13429.2S541 CAUCAAAUUGCGCUAAGAGTT CUCUUAGCGCAAUUUGAUGTT 13444.3S542 AUUGCGCUAAGAGAUUAGCTT GCUAAUCUCUUAGCGCAAUTT 13444.3S543 UUGCGCUAAGAGAUUAGCATT UGCUAAUCUCUUAGCGCAATT 13444.3S544 GAGAUUAGCACAACGUGUGTT CACACGUUGUGCUAAUCUCTT 13459.4S545 CAAUUAUAUGCCUUAUGUGTT CACAUAAGGCAUAUAAUUGTT 13414.1S546 GUACCAAUUCUAGAAUUAGTT CUAAUUCUAGAAUUGGUACTT 13414.1
S547 UUCUAGAAUUAGAGCUUCATT UGAAGCUCUAAUUCUAGAATT 13414.1S548 UUAGAGCUUCACUACCUACTT GUAGGUAGUGAAGCUCUAATT 13444.3S549 AAUAGUGUUAAGAGUGUUGTT CAACACUCUUAACACUAUUTT 13414.1S550 AUAGUGUUAAGAGUGUUGCTT GCAACACUCUUAACACUAUTT 13429.2S551 UAGUGUUAAGAGUGUUGCUTT AGCAACACUCUUAACACUATT 13429.2S552 GAGUGUUGCUAAAUUAUGUTT ACAUAAUUUAGCAACACUCTT 13414.1S553 AUUAUGUUUGGAUGCCGGCTT GCCGGCAUCCAAACAUAAUTT 13459.4S554 UUAUGUUUGGAUGCCGGCATT UGCCGGCAUCCAAACAUAATT 13459.4S555 UUAUGUGAAGUCACCCAAATT UUUGGGUGACUUCACAUAATT 13429.2S556 GUCACCCAAAUUUUCUAAATT UUUAGAAAAUUUGGGUGACTT 13414.1S557 AUUGUUCACAAUCGCUAUGTT CAUAGCGAUUGUGAACAAUTT 13429.2S558 UUGUUCACAAUCGCUAUGUTT ACAUAGCGAUUGUGAACAATT 13429.2S559 UCGCUAUGUGGCUAUUGUUTT AACAAUAGCCACAUAGCGATT 13444.3S560 GUAUUUGCUUAGGUUCUCUTT AGAGAACCUAAGCAAAUACTT 13429.2S561 UCUGUGUAACUGCUGCUUUTT AAAGCAGCAGUUACACAGATT 13444.3S562 CUGCUGCUUUUGGUGUACUTT AGUACACCAAAAGCAGCAGTT 13459.4S563 UUUUGGUGCUCCUUCUUAUTT AUAAGAAGGAGCACCAAAATT 13429.2S564 UGGCGUUAGAGAAUUGUAUTT AUACAAUUCUCUAACGCCATT 13429.2S565 UUCGUCUAACGUUACUACUTT AGUAGUAACGUUAGACGAATT 13429.2S566 CGUUACUACUAUGGAUUUCTT GAAAUCCAUAGUAGUAACGTT 13429.2S567 GGUUCUUUUCCUUGCAGCATT UGCUGCAAGGAAAAGAACCTT 13459.4S568 GUGGAUUAGACUCCCUUGATT UCAAGGGAGUCUAAUCCACTT 13459.4S569 ACCAUUCAGGUGACGAUUUTT AAAUCGUCACCUGAAUGGUTT 13444.3S570 CCAUUCAGGUGACGAUUUCTT GAAAUCGUCACCUGAAUGGTT 13459.4S571 GCUAGACUUGACAAUUUUATT UAAAAUUGUCAAGUCUAGCTT 13414.1S572 UUUUAGGUCUGGCCGCUGATT UCAGCGGCCAGACCUAAAATT 13474.5S573 UGCAGGUGUUCUUUGGCUATT UAGCCAAAGAACACCUGCATT 13459.4S574 UUCUUGGCUCAUGUGGUUUTT AAACCACAUGAGCCAAGAATT 13444.3S575 AUGGCACCCGUUUCUGCAATT UUGCAGAAACGGGUGCCAUTT 13474.5S576 UGGCACCCGUUUCUGCAAUTT AUUGCAGAAACGGGUGCCATT 13474.5S577 UGGUUAGGAUGUACAUCUUTT AAGAUGUACAUCCUAACCATT 13429.2S578 GAGCUAUGUUCAUAUCAUGTT CAUGAUAUGAACAUAGCUCTT 13429.2S579 GCGCAAUCGUGCCACACGCTT GCGUGUGGCACGAUUGCGCTT 13519.8S580 UCGUGCCACACGCGUUGAGTT CUCAACGCGUGUGGCACGATT 13504.7
S581 CUAUUGUUAAUGGCAUGAATT UUCAUGCCAUUAACAAUAGTT 13414.1S582 UGGCAUGAAGAGAUCUUUCTT GAAAGAUCUCUUCAUGCCATT 13444.3S583 GAGAUCUUUCUAUGUCUAUTT AUAGACAUAGAAAGAUCUCTT 13414.1S584 AUGGAGGCCGUGGCUUCUGTT CAGAAGCCACGGCCUCCAUTT 13504.7S585 UGGAGGCCGUGGCUUCUGCTT GCAGAAGCCACGGCCUCCATT 13519.8S586 GACUCACAAUUGGAAUUGUTT ACAAUUCCAAUUGUGAGUCTT 13429.2S587 UUGGAAUUGUCUCAAUUGUTT ACAAUUGAGACAAUUCCAATT 13414.1S588 UUGUCUCAAUUGUGACACATT UGUGUCACAAUUGAGACAATT 13429.2S589 UUGUGACACAUUUUGCACUTT AGUGCAAAAUGUGUCACAATT 13429.2S590 GUUGCUCGUGAUUUGUCACTT GUGACAAAUCACGAGCAACTT 13459.4S591 AAGACCAAUCAACCCUACUTT AGUAGGGUUGAUUGGUCUUTT 13444.3S592 AGACCAAUCAACCCUACUGTT CAGUAGGGUUGAUUGGUCUTT 13459.4S593 GACCAAUCAACCCUACUGATT UCAGUAGGGUUGAUUGGUCTT 13459.4S594 UCAACCCUACUGACCAGUCTT GACUGGUCAGUAGGGUUGATT 13474.5S595 CCCUACUGACCAGUCAUCGTT CGAUGACUGGUCAGUAGGGTT 13489.6S596 AAAUGGCGCGCUUCACCUCTT GAGGUGAAGCGCGCCAUUUTT 13489.6S597 AAUGGCGCGCUUCACCUCUTT AGAGGUGAAGCGCGCCAUUTT 13489.6S598 AUGGCGCGCUUCACCUCUATT UAGAGGUGAAGCGCGCCAUTT 13489.6S599 UGGCGCGCUUCACCUCUACTT GUAGAGGUGAAGCGCGCCATT 13504.7S600 GGCUGGUCAAAAGACCUAUTT AUAGGUCUUUUGACCAGCCTT 13459.4S601 AAGACCUAUGAGAGACAUCTT GAUGUCUCUCAUAGGUCUUTT 13444.3S602 AGACCUAUGAGAGACAUCCTT GGAUGUCUCUCAUAGGUCUTT 13459.4S603 GACCUAUGAGAGACAUCCGTT CGGAUGUCUCUCAUAGGUCTT 13474.5S604 UUUAGACAAUUUGAGAGCUTT AGCUCUCAAAUUGUCUAAATT 13414.1S605 UUUGAGAGCUAACAACACUTT AGUGUUGUUAGCUCUCAAATT 13429.2S606 CAACACUAAAGGUUCACUGTT CAGUGAACCUUUAGUGUUGTT 13444.3S607 CACUAAAGGUUCACUGCCUTT AGGCAGUGAACCUUUAGUGTT 13459.4S608 AGGUUCACUGCCUAUUAAUTT AUUAAUAGGCAGUGAACCUTT 13429.2S609 GGUUCACUGCCUAUUAAUGTT CAUUAAUAGGCAGUGAACCTT 13444.3S610 UGUCAUAGUUUUUGAUGGCTT GCCAUCAAAAACUAUGACATT 13429.2S611 GUCCAAAUGCGACGAGUCUTT AGACUCGUCGCAUUUGGACTT 13474.5S612 AUGCGACGAGUCUGCUUCUTT AGAAGCAGACUCGUCGCAUTT 13474.5S613 UGCGACGAGUCUGCUUCUATT UAGAAGCAGACUCGUCGCATT 13474.5S614 GUCUGCUUCUGUGUACUACTT GUAGUACACAGAAGCAGACTT 13459.4
S615 CCUAUUCUGUUGCUUGACCTT GGUCAAGCAACAGAAUAGGTT 13459.4S616 GCUCUUGUAUCAGACGUUGTT CAACGUCUGAUACAAGAGCTT 13459.4S617 GUUUCCGUUAAGAUGUUUGTT CAAACAUCUUAACGGAAACTT 13429.2S618 GAUGUUUGAUGCUUAUGUCTT GACAUAAGCAUCAAACAUCTT 13429.2S619 CUUUUAGUGUUCCUAUGGATT UCCAUAGGAACACUAAAAGTT 13429.2S620 AAACUUAAGGCACUUGUUGTT CAACAAGUGCCUUAAGUUUTT 13429.2S621 AACUUAAGGCACUUGUUGCTT GCAACAAGUGCCUUAAGUUTT 13444.3S622 ACUUAAGGCACUUGUUGCUTT AGCAACAAGUGCCUUAAGUTT 13444.3S623 CUUAAGGCACUUGUUGCUATT UAGCAACAAGUGCCUUAAGTT 13444.3S624 GGCACUUGUUGCUACAGCUTT AGCUGUAGCAACAAGUGCCTT 13474.5S625 AGGGUGUAGCUUUAGAUGGTT CCAUCUAAAGCUACACCCUTT 13459.4S626 GGGUGUAGCUUUAGAUGGUTT ACCAUCUAAAGCUACACCCTT 13459.4S627 GGUGUUGUUGAUACCGAUGTT CAUCGGUAUCAACAACACCTT 13459.4S628 AGGAUGUUAUUGAAUGUCUTT AGACAUUCAAUAACAUCCUTT 13414.1S629 GGAUGUUAUUGAAUGUCUCTT GAGACAUUCAAUAACAUCCTT 13429.2S630 UGUCUCAAACUUUCACAUCTT GAUGUGAAAGUUUGAGACATT 13429.2S631 ACUUUCACAUCACUCUGACTT GUCAGAGUGAUGUGAAAGUTT 13444.3S632 CUUUCACAUCACUCUGACUTT AGUCAGAGUGAUGUGAAAGTT 13444.3S633 GUGACAGGUGACAGUUGUATT UACAACUGUCACCUGUCACTT 13459.4S634 CAAUUUCAUGCUCACCUAUTT AUAGGUGAGCAUGAAAUUGTT 13429.2S635 UUUCAUGCUCACCUAUAAUTT AUUAUAGGUGAGCAUGAAATT 13414.1S636 UAAGGUUGAAAACAUGACGTT CGUCAUGUUUUCAACCUUATT 13429.2S637 GGUUGAAAACAUGACGCCCTT GGGCGUCAUGUUUUCAACCTT 13474.5S638 AACAUGACGCCCAGAGAUCTT GAUCUCUGGGCGUCAUGUUTT 13474.5S639 ACAUGACGCCCAGAGAUCUTT AGAUCUCUGGGCGUCAUGUTT 13474.5S640 CAUGACGCCCAGAGAUCUUTT AAGAUCUCUGGGCGUCAUGTT 13474.5S641 UGCAAGGCAUAUCAAUGCCTT GGCAUUGAUAUGCCUUGCATT 13459.4S642 GGCAUAUCAAUGCCCAAGUTT ACUUGGGCAUUGAUAUGCCTT 13459.4S643 UGCCCAAGUAGCAAAAAGUTT ACUUUUUGCUACUUGGGCATT 13444.3S644 GUAGCAAAAAGUCACAAUGTT CAUUGUGACUUUUUGCUACTT 13429.2S645 AAAGUCACAAUGUUUCACUTT AGUGAAACAUUGUGACUUUTT 13414.1S646 AAGUCACAAUGUUUCACUCTT GAGUGAAACAUUGUGACUUTT 13429.2S647 AGUCACAAUGUUUCACUCATT UGAGUGAAACAUUGUGACUTT 13429.2S648 GUCACAAUGUUUCACUCAUTT AUGAGUGAAACAUUGUGACTT 13429.2
S649 UGUUUCACUCAUCUGGAAUTT AUUCCAGAUGAGUGAAACATT 13429.2S650 UGUAAAAGACUACAUGUCUTT AGACAUGUAGUCUUUUACATT 13414.1S651 AAGACUACAUGUCUUUAUCTT GAUAAAGACAUGUAGUCUUTT 13414.1S652 AGACUACAUGUCUUUAUCUTT AGAUAAAGACAUGUAGUCUTT 13414.1S653 GACUACAUGUCUUUAUCUGTT CAGAUAAAGACAUGUAGUCTT 13429.2S654 CAGCUGCGUAAACAAAUUCTT GAAUUUGUUUACGCAGCUGTT 13444.3S655 ACAAAUUCGUAGUGCUGCCTT GGCAGCACUACGAAUUUGUTT 13459.4S656 CAAAUUCGUAGUGCUGCCATT UGGCAGCACUACGAAUUUGTT 13459.4S657 AUUCGUAGUGCUGCCAAGATT UCUUGGCAGCACUACGAAUTT 13459.4S658 UUCGUAGUGCUGCCAAGAATT UUCUUGGCAGCACUACGAATT 13459.4S659 GAAGAACAACAUACCUUUUTT AAAAGGUAUGUUGUUCUUCTT 13414.1S660 GAACAACAUACCUUUUAGATT UCUAAAAGGUAUGUUGUUCTT 13414.1S661 CAACAUACCUUUUAGACUATT UAGUCUAAAAGGUAUGUUGTT 13414.1S662 CAUACCUUUUAGACUAACUTT AGUUAGUCUAAAAGGUAUGTT 13414.1S663 CUUGUGCUACAACUAGACATT UGUCUAGUUGUAGCACAAGTT 13444.3S664 CUAGACAGGUUGUCAAUGUTT ACAUUGACAACCUGUCUAGTT 13444.3S665 CUACUAAAAUCUCACUCAATT UUGAGUGAGAUUUUAGUAGTT 13414.1S666 AAUCUCACUCAAGGGUGGUTT ACCACCCUUGAGUGAGAUUTT 13459.4S667 AUCUCACUCAAGGGUGGUATT UACCACCCUUGAGUGAGAUTT 13459.4S668 UCUCACUCAAGGGUGGUAATT UUACCACCCUUGAGUGAGATT 13459.4S669 GGGUGGUAAGAUUGUUAGUTT ACUAACAAUCUUACCACCCTT 13444.3S670 ACUUAUGCUUAAGGCCACATT UGUGGCCUUAAGCAUAAGUTT 13444.3S671 CUUAUGCUUAAGGCCACAUTT AUGUGGCCUUAAGCAUAAGTT 13444.3S672 GGCCACAUUAUUGUGCGUUTT AACGCACAAUAAUGUGGCCTT 13459.4S673 UCCAUGAUGGUUACACAAATT UUUGUGUAACCAUCAUGGATT 13429.2S674 AUCAUUGGUUACAAAGCCATT UGGCUUUGUAACCAAUGAUTT 13429.2S675 UCAUUGGUUACAAAGCCAUTT AUGGCUUUGUAACCAAUGATT 13429.2S676 AGCCAUUCAGGAUGGUGUCTT GACACCAUCCUGAAUGGCUTT 13474.5S677 GCCAUUCAGGAUGGUGUCATT UGACACCAUCCUGAAUGGCTT 13474.5S678 AUAAACAUGCUGGUUUUGATT UCAAAACCAGCAUGUUUAUTT 13414.1S679 UAAACAUGCUGGUUUUGACTT GUCAAAACCAGCAUGUUUATT 13429.2S680 ACAUGCUGGUUUUGACGCATT UGCGUCAAAACCAGCAUGUTT 13459.4S681 CAUGCUGGUUUUGACGCAUTT AUGCGUCAAAACCAGCAUGTT 13459.4S682 AAAUGACAAAAGCUGCCCUTT AGGGCAGCUUUUGUCAUUUTT 13444.3
S683 AAUGACAAAAGCUGCCCUGTTCAGGGCAGCUUUUGUCAUUTT 13459.4S684 AUGACAAAAGCUGCCCUGUTTACAGGGCAGCUUUUGUCAUTT 13459.4S685 UGACAAAAGCUGCCCUGUATTUACAGGGCAGCUUUUGUCATT 13459.4S686 AAGCUGCCCUGUAGUAGCUTTAGCUACUACAGGGCAGCUUTT 13474.5S687 AGCUGCCCUGUAGUAGCUGTTCAGCUACUACAGGGCAGCUTT 13489.6S688 GCUGCCCUGUAGUAGCUGCTTGCAGCUACUACAGGGCAGCTT 13504.7S689 GAGAGAUUGGUUUCAUAGUTTACUAUGAAACCAAUCUCUCTT 13429.2S690 UCAAUGGUGACUUCUUGCATTUGCAAGAAGUCACCAUUGATT 13444.3S691 UGGUGACUUCUUGCAUUUUTTAAAAUGCAAGAAGUCACCATT 13429.2S692 CAUUUGCUACACACCUUCCTTGGAAGGUGUGUAGCAAAUGTT 13459.4S693 ACUCAUUGAGUAUAGUGAUTTAUCACUAUACUCAAUGAGUTT 13414.1S694 CUCAUUGAGUAUAGUGAUUTTAAUCACUAUACUCAAUGAGTT 13414.1S695 UUUUUAAGGAUGCUAUGGGTTCCCAUAGCAUCCUUAAAAATT 13429.2S696 GGAUGCUAUGGGCAAACCUTTAGGUUUGCCCAUAGCAUCCTT 13474.5S697 ACCUGUGCCAUAUUGUUAUTTAUAACAAUAUGGCACAGGUTT 13429.2S698 CCUGUGCCAUAUUGUUAUGTTCAUAACAAUAUGGCACAGGTT 13444.3S699 UUUGCUAGAGGGUUCUAUUTTAAUAGAACCCUCUAGCAAATT 13429.2S700 CACUUACCUGGAGGGUUCUTTAGAACCCUCCAGGUAAGUGTT 13474.5S701 CAACUUUUGAUGCUGAGUATTUACUCAGCAUCAAAAGUUGTT 13429.2S702 CUUUUGAUGCUGAGUACUGTTCAGUACUCAGCAUCAAAAGTT 13444.3S703 AGGUCAGAAGUAGGUAUUUTTAAAUACCUACUUCUGACCUTT 13429.2S704 GGUCAGAAGUAGGUAUUUGTTCAAAUACCUACUUCUGACCTT 13444.3S705 GUAGGUAUUUGCCUAUCUATTUAGAUAGGCAAAUACCUACTT 13429.2S706 UAAUGAGCAUUACAGAGCUTTAGCUCUGUAAUGCUCAUUATT 13429.2S707 UGAGCAUUACAGAGCUCUATTUAGAGCUCUGUAAUGCUCATT 13444.3S708 UCUCAUAGCUAACAUCUUUTTAAAGAUGUUAGCUAUGAGATT 13414.1S709 CAUCUUUACUCCUCUUGUGTTCACAAGAGGAGUAAAGAUGTT 13444.3S710 CCUGUGGGUGCUUUAGAUGTTCAUCUAAAGCACCCACAGGTT 13474.5S711 AUUCAGACGUGUUUUUGGUTTACCAAAAACACGUCUGAAUTT 13429.2S712 UUCAGACGUGUUUUUGGUGTTCACCAAAAACACGUCUGAATT 13444.3S713 CCAUGUUGUUGCUGCUAAUTTAUUAGCAGCAACAACAUGGTT 13444.3S714 UGCACUUUUGUUUUUGAUGTTCAUCAAAAACAAAAGUGCATT 13414.1S715 UGAUGUUUCAUUCUUGGCUTTAGCCAAGAAUGAAACAUCATT 13429.2S716 UGGUUUGCCAUGUUUUCUCTTGAGAAAACAUGGCAAACCATT 13444.3
S717 CAGCAAUCUAUGUAUUCUGTTCAGAAUACAUAGAUUGCUGTT 13429.2S718 GCACUGCCAUUGGUUCUUUTTAAAGAACCAAUGGCAGUGCTT 13459.4S719 CAACUAUCUUAGGAAAAGATTUCUUUUCCUAAGAUAGUUGTT 13414.1S720 CUAUCUUAGGAAAAGAGUCTTGACUCUUUUCCUAAGAUAGTT 13429.2S721 AAGAGUCAUGUUUAAUGGATTUCCAUUAAACAUGACUCUUTT 13414.1S722 AGAGUCAUGUUUAAUGGAGTTCUCCAUUAAACAUGACUCUTT 13429.2S723 GAGUCAUGUUUAAUGGAGUTTACUCCAUUAAACAUGACUCTT 13429.2S724 CAAGGAAAUGUACCUAAAATTUUUUAGGUACAUUUCCUUGTT 13414.1S725 GGAAAUGUACCUAAAAUUGTTCAAUUUUAGGUACAUUUCCTT 13414.1S726 AUGUACCUAAAAUUGCGUATTUACGCAAUUUUAGGUACAUTT 13414.1S727 UGUACCUAAAAUUGCGUAGTTCUACGCAAUUUUAGGUACATT 13429.2S728 AAUUGCGUAGCGAGACACUTTAGUGUCUCGCUACGCAAUUTT 13459.4S729 AUUGCGUAGCGAGACACUGTTCAGUGUCUCGCUACGCAAUTT 13474.5S730 UUGCGUAGCGAGACACUGUTTACAGUGUCUCGCUACGCAATT 13474.5S731 CAGGUAUCUUGCUCUAUAUTTAUAUAGAGCAAGAUACCUGTT 13429.2S732 CAAGUACAAGUAUUUCAGUTTACUGAAAUACUUGUACUUGTT 13414.1S733 GUACAAGUAUUUCAGUGGATTUCCACUGAAAUACUUGUACTT 13429.2S734 GUAUUUCAGUGGAGCCUUATTUAAGGCUCCACUGAAAUACTT 13444.3S735 GCAGCUUGCUGCCACUUAGTTCUAAGUGGCAGCAAGCUGCTT 13489.6S736 AGGCUCUAAAUGACUUUAGTTCUAAAGUCAUUUAGAGCCUTT 13429.2S737 GGCUCUAAAUGACUUUAGCTTGCUAAAGUCAUUUAGAGCCTT 13444.3S738 AUGACUUUAGCAACUCAGGTTCCUGAGUUGCUAAAGUCAUTT 13444.3S739 UGACUUUAGCAACUCAGGUTTACCUGAGUUGCUAAAGUCATT 13444.3S740 CUCAGGUGCUGAUGUUCUCTTGAGAACAUCAGCACCUGAGTT 13474.5S741 CCACCACAGACAUCAAUCATTUGAUUGAUGUCUGUGGUGGTT 13459.4S742 UCACUUCUGCUGUUCUGCATTUGCAGAACAGCAGAAGUGATT 13459.4S743 AAUGGCAUUCCCGUCAGGCTTGCCUGACGGGAAUGCCAUUTT 13489.6S744 AUGGCAUUCCCGUCAGGCATTUGCCUGACGGGAAUGCCAUTT 13489.6S745 UGGCAUUCCCGUCAGGCAATTUUGCCUGACGGGAAUGCCATT 13489.6S746 AGUUGAAGGGUGCAUGGUATTUACCAUGCACCCUUCAACUTT 13459.4S747 GUUGAAGGGUGCAUGGUACTTGUACCAUGCACCCUUCAACTT 13474.5S745 GGGUGCAUGGUACAAGUAATTUUACUUGUACCAUGCACCCTT 13459.4S749 GUAACCUGUGGAACUACAATTUUGUAGUUCCACAGGUUACTT 13444.3S750 CCUGUGGAACUACAACUCUTTAGAGUUGUAGUUCCACAGGTT 13459.4
S751CUACAACUCUUAAUGGAUUTT AAUCCAUUAAGAGUUGUAGTT 13414.1S752UGGAUUGUGGUUGGAUGACTT GUCAUCCAACCACAAUCCATT 13459.4S753GACAUGUCAUUUGCACAGCTT GCUGUGCAAAUGACAUGUCTT 13459.4S754GACAUGCUUAAUCCUAACUTT AGUUAGGAUUAAGCAUGUCTT 13429.2S755UCCUAACUAUGAAGAUCUGTT CAGAUCUUCAUAGUUAGGATT 13429.2S756CUAUGAAGAUCUGCUCAUUTT AAUGAGCAGAUCUUCAUAGTT 13429.2S757GAUCUGCUCAUUCGCAAAUTT AUUUGCGAAUGAGCAGAUCTT 13444.3S758AUCCAACCAUAGCUUUCUUTT AAGAAAGCUAUGGUUGGAUTT 13429.2S759UCCAACCAUAGCUUUCUUGTT CAAGAAAGCUAUGGUUGGATT 13444.3S760CCAUAGCUUUCUUGUUCAGTT CUGAACAAGAAAGCUAUGGTT 13444.3S761UGUUCAACUUCGUGUUAUUTT AAUAACACGAAGUUGAACATT 13414.1S762CUUCGUGUUAUUGGCCAUUTT AAUGGCCAAUAACACGAAGTT 13444.3S763AAUUGUCUGCUUAGGCUUATT UAAGCCUAAGCAGACAAUUTT 13429.2S764AUUGUCUGCUUAGGCUUAATT UUAAGCCUAAGCAGACAAUTT 13429.2S765UUGUCUGCUUAGGCUUAAATT UUUAAGCCUAAGCAGACAATT 13429.2S766AGUUGAUACUUCUAACCCUTT AGGGUUAGAAGUAUCAACUTT 13429.2S767GUUGAUACUUCUAACCCUATT UAGGGUUAGAAGUAUCAACTT 13429.2S768CCCUAAGACACCCAAGUAUTT AUACUUGGGUGUCUUAGGGTT 13459.4S769GACACCCAAGUAUAAAUUUTT AAAUUUAUACUUGGGUGUCTT 13414.1S770GUAUAAAUUUGUCCGUAUCTT GAUACGGACAAAUUUAUACTT 13414.1S771AUUUGUCCGUAUCCAACCUTT AGGUUGGAUACGGACAAAUTT 13444.3S772UUUGUCCGUAUCCAACCUGTT CAGGUUGGAUACGGACAAATT 13459.4S773CCUGGUCAAACAUUUUCAGTT CUGAAAAUGUUUGACCAGGTT 13444.3S774ACAUUUUCAGUUCUAGCAUTT AUGCUAGAACUGAAAAUGUTT 13414.1S775CAUUUUCAGUUCUAGCAUGTT CAUGCUAGAACUGAAAAUGTT 13429.2S776UGGUUCACCAUCUGGUGUUTT AACACCAGAUGGUGAACCATT 13459.4S777UCAUACCAUUAAAGGUUCUTT AGAACCUUUAAUGGUAUGATT 13414.1S778AGGUUCUUUCCUUAAUGGATT UCCAUUAAGGAAAGAACCUTT 13429.2S779GGUUCUUUCCUUAAUGGAUTT AUCCAUUAAGGAAAGAACCTT 13429.2S780UGGAUCAUGUGGUAGUGUUTT AACACUACCACAUGAUCCATT 13444.3S781CAUUGAUUAUGAUUGCGUGTT CACGCAAUCAUAAUCAAUGTT 13429.2S782CAGGAGUACACGCUGGUACTT GUACCAGCGUGUACUCCUGTT 13489.6S783GGUAAAUUCUAUGGUCCAUTT AUGGACCAUAGAAUUUACCTT 13429.2S784AUUCUAUGGUCCAUUUGUUTT AACAAAUGGACCAUAGAAUTT 13414.1
S785 UUCUAUGGUCCAUUUGUUGTTCAACAAAUGGACCAUAGAATT 13429.2S786 ACUGCACAGGCUGCAGGUATTUACCUGCAGCCUGUGCAGUTT 13489.6S787 CUGCACAGGCUGCAGGUACTTGUACCUGCAGCCUGUGCAGTT 13504.7S788 CAUUAAAUGUUUUGGCAUGTTCAUGCCAAAACAUUUAAUGTT 13414.1S789 AUGUUUUGGCAUGGCUGUATTUACAGCCAUGCCAAAACAUTT 13444.3S790 UGUUUUGGCAUGGCUGUAUTTAUACAGCCAUGCCAAAACATT 13444.3S791 UGGUGAUAGGUGGUUUCUUTTAAGAAACCACCUAUCACCATT 13444.3S792 UAGAUUCACCACUACUUUGTTCAAAGUAGUGGUGAAUCUATT 13429.2S793 UGACUUUAACCUUGUGGCATTUGCCACAAGGUUAAAGUCATT 13444.3S794 CCUUGUGGCAAUGAAGUACTTGUACUUCAUUGCCACAAGGTT 13459.4S795 UGAAGUACAACUAUGAACCTTGGUUCAUAGUUGUACUUCATT 13429.2S796 GUACAACUAUGAACCUUUGTTCAAAGGUUCAUAGUUGUACTT 13429.2S797 CUAUGAACCUUUGACACAATTUUGUGUCAAAGGUUCAUAGTT 13429.2S798 CCUUUGACACAAGAUCAUGTTCAUGAUCUUGUGUCAAAGGTT 13444.3S799 GAUCAUGUUGACAUAUUGGTTCCAAUAUGUCAACAUGAUCTT 13429.2S800 ACAGGAAUUGCCGUCUUAGTTCUAAGACGGCAAUUCCUGUTT 13459.4S801 CAGGAAUUGCCGUCUUAGATTUCUAAGACGGCAAUUCCUGTT 13459.4S802 UUGCCGUCUUAGAUAUGUGTTCACAUAUCUAAGACGGCAATT 13444.3S803 AGAGCUGCUGCAGAAUGGUTTACCAUUCUGCAGCAGCUCUTT 13474.5S804 GAGCUGCUGCAGAAUGGUATTUACCAUUCUGCAGCAGCUCTT 13474.5S805 UGGUAUGAAUGGUCGUACUTTAGUACGACCAUUCAUACCATT 13444.3S806 UGGUCGUACUAUCCUUGGUTTACCAAGGAUAGUACGACCATT 13459.4S807 GAUGAGUUUACACCAUUUGTTCAAAUGGUGUAAACUCAUCTT 13429.2S808 UGCUCUGGUGUUACCUUCCTTGGAAGGUAACACCAGAGCATT 13474.5S809 GGUAAGUUCAAGAAAAUUGTTCAAUUUUCUUGAACUUACCTT 13414.1S810 GAAAAUUGUUAAGGGCACUTTAGUGCCCUUAACAAUUUUCTT 13429.2S811 AAUUGUUAAGGGCACUCAUTTAUGAGUGCCCUUAACAAUUTT 13429.2S812 AUUGUUAAGGGCACUCAUCTTGAUGAGUGCCCUUAACAAUTT 13444.3S813 UUGUUAAGGGCACUCAUCATTUGAUGAGUGCCCUUAACAATT 13444.3S814 GGGCACUCAUCAUUGGAUGTTCAUCCAAUGAUGAGUGCCCTT 13474.5S815 CUUUCUUGACAUCACUAUUTTAAUAGUGAUGUCAAGAAAGTT 13414.1S816 AGUACACAGUGGUCACUGUTTACAGUGACCACUGUGUACUTT 13459.4S817 GUACACAGUGGUCACUGUUTTAACAGUGACCACUGUGUACTT 13459.4S818 UGCUUUCUUGCCAUUUACUTTAGUAAAUGGCAAGAAAGCATT 13429.2
S819 UUGCUGCAUGUGCUAUGCUTTAGCAUAGCACAUGCAGCAATT 13459.4S820 GCAUAAGCACGCAUUCUUGTTCAAGAAUGCGUGCUUAUGCTT 13459.4S821 GCACGCAUUCUUGUGCUUGTTCAAGCACAAGAAUGCGUGCTT 13474.5S822 UAUGGUCUACAUGCCUGCUTTAGCAGGCAUGUAGACCAUATT 13459.4S823 UUGGCUGACACUAGCUUGUTTACAAGCUAGUGUCAGCCAATT 13459.4S824 GGAUUGUGUUAUGUAUGCUTTAGCAUACAUAACACAAUCCTT 13429.2S825 UGUCAUUACACUUGUUUACTTGUAAACAAGUGUAAUGACATT 13414.1S826 AGUCUACUAUGGUAAUGCUTTAGCAUUACCAUAGUAGACUTT 13429.2S827 GUCUACUAUGGUAAUGCUUTTAAGCAUUACCAUAGUAGACTT 13429.2S828 UGCUUUAGAUCAAGCUAUUTTAAUAGCUUGAUCUAAAGCATT 13414.1S829 GCUAUUUCCAUGUGGGCCUTTAGGCCCACAUGGAAAUAGCTT 13474.5S830 CCUCUAACUAUUCUGGUGUTTACACCAGAAUAGUUAGAGGTT 13444.3S831 CUAUUCUGGUGUCGUUACGTTCGUAACGACACCAGAAUAGTT 13459.4S832 CACCUUACAGUGUAUCAUGTTCAUGAUACACUGUAAGGUGTT 13444.3S833 CCGUUACUUCAGGCUUACUTTAGUAAGCCUGAAGUAACGGTT 13459.4S834 UUUAGGUAUAUGAACUCCCTTGGGAGUUCAUAUACCUAAATT 13429.2S835 CUCCCAGGGGCUUUUGCCUTTAGGCAAAAGCCCCUGGGAGTT 13504.7S836 GAGUAGUAUUGAUGCUUUCTTGAAAGCAUCAAUACUACUCTT 13429.2S837 CAUUAAGUUGUUGGGUAUUTTAAUACCCAACAACUUAAUGTT 13414.1S838 GUUGUUGGGUAUUGGAGGUTTACCUCCAAUACCCAACAACTT 13459.4S839 ACCAUGUAUCAAGGUUGCUTTAGCAACCUUGAUACAUGGUTT 13444.3S840 CCAUGUAUCAAGGUUGCUATTUAGCAACCUUGAUACAUGGTT 13444.3S841 GGUUGCUACUGUACAGUCUTTAGACUGUACAGUAGCAACCTT 13459.4S842 AAUGUCUGACGUAAAGUGCTTGCACUUUACGUCAGACAUUTT 13444.3S843 AUGUCUGACGUAAAGUGCATTUGCACUUUACGUCAGACAUTT 13444.3S844 UGUCUGACGUAAAGUGCACTTGUGCACUUUACGUCAGACATT 13459.4S845 AGUGCACAUCUGUGGUACUTTAGUACCACAGAUGUGCACUTT 13459.4S846 GUGCACAUCUGUGGUACUGTTCAGUACCACAGAUGUGCACTT 13474.5S847 CAACUUAGAGUAGAGUCAUTTAUGACUCUACUCUAAGUUGTT 13429.2S848 CUUAGAGUAGAGUCAUCUUTTAAGAUGACUCUACUCUAAGTT 13429.2S849 AUUGUGGGCACAAUGUGUATTUACACAUUGUGCCCACAAUTT 13444.3S850 UUGUGGGCACAAUGUGUACTTGUACACAUUGUGCCCACAATT 13459.4S851 UGUGUACAACUCCACAAUGTTCAUUGUGGAGUUGUACACATT 13444.3S852 CUCCACAAUGAUAUUCUUCTTGAAGAAUAUCAUUGUGGAGTT 13429.2
S853 AAGACACAACUGAAGCUUUTT AAAGCUUCAGUUGUGUCUUTT 13429.2S854 AGACACAACUGAAGCUUUCTT GAAAGCUUCAGUUGUGUCUTT 13444.3S855 GACACAACUGAAGCUUUCGTT CGAAAGCUUCAGUUGUGUCTT 13459.4S856 CUGAAGCUUUCGAGAAGAUTT AUCUUCUCGAAAGCUUCAGTT 13444.3S857 GCUUUCGAGAAGAUGGUUUTT AAACCAUCUUCUCGAAAGCTT 13444.3S858 GAUGGUUUCUCUUUUGUCUTT AGACAAAAGAGAAACCAUCTT 13429.2S859 UAGGUUGUGCGAGGAAAUGTT CAUUUCCUCGCACAACCUATT 13459.4S860 AUGCUCGAUAACCGUGCUATT UAGCACGGUUAUCGAGCAUTT 13459.4S861 UGCUCGAUAACCGUGCUACTT GUAGCACGGUUAUCGAGCATT 13474.5S862 CCGUGCUACUCUUCAGGCUTT AGCCUGAAGAGUAGCACGGTT 13489.6S863 UGGUGAUUCUGAAGUCGUUTT AACGACUUCAGAAUCACCATT 13444.3S864 GUCGUUCUCAAAAAGUUAATT UUAACUUUUUGAGAACGACTT 13414.1S865 AGAAAUCUUUGAAUGUGGCTT GCCACAUUCAAAGAUUUCUTT 13429.2S866 GAAAUCUUUGAAUGUGGCUTT AGCCACAUUCAAAGAUUUCTT 13429.2S867 AUCUUUGAAUGUGGCUAAATT UUUAGCCACAUUCAAAGAUTT 13414.1S868 UCUUUGAAUGUGGCUAAAUTT AUUUAGCCACAUUCAAAGATT 13414.1S869 AUCUGAGUUUGACCGUGAUTT AUCACGGUCAAACUCAGAUTT 13444.3S870 UCUGAGUUUGACCGUGAUGTT CAUCACGGUCAAACUCAGATT 13459.4S871 CGCAAGUUGGAAAAGAUGGTT CCAUCUUUUCCAACUUGCGTT 13459.4S872 GUUGGAAAAGAUGGCAGAUTT AUCUGCCAUCUUUUCCAACTT 13444.3S873 AAGAUGGCAGAUCAGGCUATT UAGCCUGAUCUGCCAUCUUTT 13459.4S874 AGAUGGCAGAUCAGGCUAUTT AUAGCCUGAUCUGCCAUCUTT 13459.4S875 GAUGGCAGAUCAGGCUAUGTT CAUAGCCUGAUCUGCCAUCTT 13474.5S876 AUGUACAAACAGGCAAGAUTT AUCUUGCCUGUUUGUACAUTT 13429.2S877 UGUACAAACAGGCAAGAUCTT GAUCUUGCCUGUUUGUACATT 13444.3S878 ACAGGCAAGAUCUGAGGACTT GUCCUCAGAUCUUGCCUGUTT 13474.5S879 CAGGCAAGAUCUGAGGACATT UGUCCUCAGAUCUUGCCUGTT 13474.5S880 GAUCUGAGGACAAGAGGGCTT GCCCUCUUGUCCUCAGAUCTT 13489.6S881 GAGGGCAAAAGUAACUAGUTT ACUAGUUACUUUUGCCCUCTT 13444.3S882 AAGUAACUAGUGCUAUGCATT UGCAUAGCACUAGUUACUUTT 13429.2S883 AGUAACUAGUGCUAUGCAATT UUGCAUAGCACUAGUUACUTT 13429.2S884 GUAACUAGUGCUAUGCAAATT UUUGCAUAGCACUAGUUACTT 13429.2S885 CUAGUGCUAUGCAAACAAUTT AUUGUUUGCAUAGCACUAGTT 13429.2S886 ACAAUGCUCUUCACUAUGCTT GCAUAGUGAAGAGCAUUGUTT 13444.3
S887 UGCUCUUCACUAUGCUUAGTT CUAAGCAUAGUGAAGAGCATT 13444.3S888 GCUUGAUAAUGAUGCACUUTT AAGUGCAUCAUUAUCAAGCTT 13429.2S889 UGAUGCACUUAACAACAUUTT AAUGUUGUUAAGUGCAUCATT 13414.1S890 CAACAUUAUCAACAAUGCGTT CGCAUUGUUGAUAAUGUUGTT 13429.2S891 CAUUAUCAACAAUGCGCGUTT ACGCGCAUUGUUGAUAAUGTT 13444.3S892 CAAUGCGCGUGAUGGUUGUTT ACAACCAUCACGCGCAUUGTT 13474.5S893 UGCGCGUGAUGGUUGUGUUTT AACACAACCAUCACGCGCATT 13474.5S894 CAUCAUACCAUUGACUACATT UGUAGUCAAUGGUAUGAUGTT 13429.2S895 ACUCAUGGUUGUUGUCCCUTT AGGGACAACAACCAUGAGUTT 13459.4S896 CUCAUGGUUGUUGUCCCUGTT CAGGGACAACAACCAUGAGTT 13474.5S897 GAACACUUGUGAUGGUAACTT GUUACCAUCACAAGUGUUCTT 13444.3S898 CACUUGUGAUGGUAACACCTT GGUGUUACCAUCACAAGUGTT 13459.4S899 CACCUUUACAUAUGCAUCUTT AGAUGCAUAUGUAAAGGUGTT 13429.2S900 AUCCAGCAAGUUGUUGAUGTT CAUCAACAACUUGCUGGAUTT 13444.3S901 UCCAGCAAGUUGUUGAUGCTT GCAUCAACAACUUGCUGGATT 13459.4S902 GUUGUUGAUGCGGAUAGCATT UGCUAUCCGCAUCAACAACTT 13459.4S903 GAUUGUUCAACUUAGUGAATT UUCACUAAGUUGAACAAUCTT 13414.1S904 CUUAGUGAAAUUAACAUGGTT CCAUGUUAAUUUCACUAAGTT 13414.1S905 AUUAACAUGGACAAUUCACTT GUGAAUUGUCCAUGUUAAUTT 13414.1S906 UUAACAUGGACAAUUCACCTT GGUGAAUUGUCCAUGUUAATT 13429.2S907 CAUGGACAAUUCACCAAAUTT AUUUGGUGAAUUGUCCAUGTT 13429.2S908 UUCACCAAAUUUGGCUUGGTT CCAAGCCAAAUUUGGUGAATT 13444.3S909 AUUUGGCUUGGCCUCUUAUTT AUAAGAGGCCAAGCCAAAUTT 13444.3S910 UUUGGCUUGGCCUCUUAUUTT AAUAAGAGGCCAAGCCAAATT 13444.3S911 GAGCCAACUCAGCUGUUAATT UUAACAGCUGAGUUGGCUCTT 13459.4S912 CUCAGCUGUUAAACUACAGTT CUGUAGUUUAACAGCUGAGTT 13444.3S913 ACUACAGAAUAAUGAACUGTT CAGUUCAUUAUUCUGUAGUTT 13414.1S914 CUACAGAAUAAUGAACUGATT UCAGUUCAUUAUUCUGUAGTT 13414.1S915 UAAUGAACUGAGUCCAGUATT UACUGGACUCAGUUCAUUATT 13429.2S916 UGAACUGAGUCCAGUAGCATT UGCUACUGGACUCAGUUCATT 13459.4S917 CUGAGUCCAGUAGCACUACTT GUAGUGCUACUGGACUCAGTT 13474.5S918 ACAGCUUGUACUGAUGACATT UGUCAUCAGUACAAGCUGUTT 13444.3S919 CAGCUUGUACUGAUGACAATT UUGUCAUCAGUACAAGCUGTT 13444.3S920 UGCACUUGCCUACUAUAACTT GUUAUAGUAGGCAAGUGCATT 13444.3
S921 CAAUUCGAAGGGAGGUAGGTT CCUACCUCCCUUCGAAUUGTT 13474.5S922 UUCGAAGGGAGGUAGGUUUTT AAACCUACCUCCCUUCGAATT 13459.4S923 GGGAGGUAGGUUUGUGCUGTT CAGCACAAACCUACCUCCCTT 13489.6S924 GAUCUCAAAUGGGCUAGAUTT AUCUAGCCCAUUUGAGAUCTT 13444.3S925 AUGGGCUAGAUUCCCUAAGTT CUUAGGGAAUCUAGCCCAUTT 13459.4S926 UGGGCUAGAUUCCCUAAGATT UCUUAGGGAAUCUAGCCCATT 13459.4S927 GAGUGAUGGUACAGGUACATT UGUACCUGUACCAUCACUCTT 13459.4S928 UUUACACAGAACUGGAACCTT GGUUCCAGUUCUGUGUAAATT 13444.3S929 CUGGAACCACCUUGUAGGUTT ACCUACAAGGUGGUUCCAGTT 13474.5S930 CCACCUUGUAGGUUUGUUATT UAACAAACCUACAAGGUGGTT 13444.3S931 AAGGGCCUAAAGUGAAAUATT UAUUUCACUUUAGGCCCUUTT 13429.2S932 AGGGCCUAAAGUGAAAUACTT GUAUUUCACUUUAGGCCCUTT 13444.3S933 GGGCCUAAAGUGAAAUACUTT AGUAUUUCACUUUAGGCCCTT 13444.3S934 AGUGAAAUACUUGUACUUCTT GAAGUACAAGUAUUUCACUTT 13414.1S935 GUGAAAUACUUGUACUUCATT UGAAGUACAAGUAUUUCACTT 13414.1S936 UACUUGUACUUCAUCAAAGTT CUUUGAUGAAGUACAAGUATT 13414.1S937 AGGCUUAAACAACCUAAAUTT AUUUAGGUUGUUUAAGCCUTT 13414.1S938 GGCUUAAACAACCUAAAUATT UAUUUAGGUUGUUUAAGCCTT 13414.1S939 ACAACCUAAAUAGAGGUAUTT AUACCUCUAUUUAGGUUGUTT 13414.1S940 CAACCUAAAUAGAGGUAUGTT CAUACCUCUAUUUAGGUUGTT 13429.2S941 CCUAAAUAGAGGUAUGGUGTT CACCAUACCUCUAUUUAGGTT 13444.3S942 AUAGAGGUAUGGUGCUGGGTT CCCAGCACCAUACCUCUAUTT 13474.5S943 UAGAGGUAUGGUGCUGGGCTT GCCCAGCACCAUACCUCUATT 13489.6S944 AUGCUACAGAAGUACCUGCTT GCAGGUACUUCUGUAGCAUTT 13459.4S945 UGCUACAGAAGUACCUGCCTT GGCAGGUACUUCUGUAGCATT 13474.5S946 GUACCUGCCAAUUCAACUGTT CAGUUGAAUUGGCAGGUACTT 13459.4S947 UUCAACUGUGCUUUCCUUCTT GAAGGAAAGCACAGUUGAATT 13444.3S948 CUGUGCUUUCCUUCUGUGCTT GCACAGAAGGAAAGCACAGTT 13474.5S949 AGCAUAUAAGGAUUACCUATT UAGGUAAUCCUUAUAUGCUTT 13414.1S950 GCAUAUAAGGAUUACCUAGTT CUAGGUAAUCCUUAUAUGCTT 13429.2S951 GGAUUACCUAGCAAGUGGATT UCCACUUGCUAGGUAAUCCTT 13459.4S952 GUGGAGGACAACCAAUCACTT GUGAUUGGUUGUCCUCCACTT 13474.5S953 CCAAUCACCAACUGUGUGATT UCACACAGUUGGUGAUUGGTT 13459.4S954 UCACCAACUGUGUGAAGAUTT AUCUUCACACAGUUGGUGATT 13444.3
S955 CUGUGUGAAGAUGUUGUGUTT ACACAACAUCUUCACACAGTT 13444.3S956 GAUGUUGUGUACACACACUTT AGUGUGUGUACACAACAUCTT 13444.3S957 UUACUGUAACACCAGAAGCTT GCUUCUGGUGUUACAGUAATT 13444.3S958 CACCAGAAGCUAACAUGGATT UCCAUGUUAGCUUCUGGUGTT 13459.4S959 GCUAACAUGGACCAAGAGUTT ACUCUUGGUCCAUGUUAGCTT 13459.4S960 CAUGGACCAAGAGUCCUUUTT AAAGGACUCUUGGUCCAUGTT 13459.4S961 GAGUCCUUUGGUGGUGCUUTT AAGCACCACCAAAGGACUCTT 13474.5S962 AUCCUAAAGGAUUCUGUGATT UCACAGAAUCCUUUAGGAUTT 13429.2S963 UCCUAAAGGAUUCUGUGACTT GUCACAGAAUCCUUUAGGATT 13444.3S964 AGGAUUCUGUGACUUGAAATT UUUCAAGUCACAGAAUCCUTT 13429.2S965 GGAUUCUGUGACUUGAAAGTT CUUUCAAGUCACAGAAUCCTT 13444.3S966 AGGUAAGUACGUCCAAAUATT UAUUUGGACGUACUUACCUTT 13429.2S967 GGUAAGUACGUCCAAAUACTT GUAUUUGGACGUACUUACCTT 13444.3S968 GUACGUCCAAAUACCUACCTT GGUAGGUAUUUGGACGUACTT 13459.4S969 AUACCUACCACUUGUGCUATT UAGCACAAGUGGUAGGUAUTT 13444.3S970 UACCUACCACUUGUGCUAATT UUAGCACAAGUGGUAGGUATT 13444.3S971 UGACCCAGUGGGUUUUACATT UGUAAAACCCACUGGGUCATT 13459.4S972 ACACAGUCUGUACCGUCUGTT CAGACGGUACAGACUGUGUTT 13474.5S973 CACAGUCUGUACCGUCUGCTT GCAGACGGUACAGACUGUGTT 13489.6S974 UGUGGAAAGGUUAUGGCUGTT CAGCCAUAACCUUUCCACATT 13459.4S975 AGGUUAUGGCUGUAGUUGUTT ACAACUACAGCCAUAACCUTT 13444.3S976 GGUUAUGGCUGUAGUUGUGTT CACAACUACAGCCAUAACCTT 13459.4S977 CUCCGCGAACCCUUGAUGCTT GCAUCAAGGGUUCGCGGAGTT 13504.7S978 CCCUUGAUGCAGUCUGCGGTT CCGCAGACUGCAUCAAGGGTT 13504.7S979 CGUUUUUAAACGGGUUUGCTT GCAAACCCGUUUAAAAACGTT 13444.3S980 ACGGGUUUGCGGUGUAAGUTT ACUUACACCGCAAACCCGUTT 13474.5S981 CGGGUUUGCGGUGUAAGUGTT CACUUACACCGCAAACCCGTT 13489.6S982 GUGCAGCCCGUCUUACACCTT GGUGUAAGACGGGCUGCACTT 13504.7S983 CGAAAAAGUUGCUGGUUUUTT AAAACCAGCAACUUUUUCGTT 13429.2S984 AAAGUUGCUGGUUUUGCAATT UUGCAAAACCAGCAACUUUTT 13429.2S985 AAGUUGCUGGUUUUGCAAATT UUUGCAAAACCAGCAACUUTT 13429.2S986 AGUUGCUGGUUUUGCAAAGTT CUUUGCAAAACCAGCAACUTT 13444.3S987 GUUGCUGGUUUUGCAAAGUTT ACUUUGCAAAACCAGCAACTT 13444.3S988 GUUCCUAAAAACUAAUUGCTT GCAAUUAGUUUUUAGGAACTT 13414.1
S989 AAACUAAUUGCUGUCGCUUTTAAGCGACAGCAAUUAGUUUTT 13429.2S990 AACUAAUUGCUGUCGCUUCTTGAAGCGACAGCAAUUAGUUTT 13444.3S991 ACUAAUUGCUGUCGCUUCCTTGGAAGCGACAGCAAUUAGUTT 13459.4S992 GGCAAUUUAUUAGACUCUUTTAAGAGUCUAAUAAAUUGCCTT 13414.1S993 GAGACUAUUUAUAACUUGGTTCCAAGUUAUAAAUAGUCUCTT 13414.1S994 CUUGGUUAAAGAUUGUCCATTUGGACAAUCUUUAACCAAGTT 13429.2S995 AGAUUGUCCAGCGGUUGCUTTAGCAACCGCUGGACAAUCUTT 13474.5S996 CUAAAUACACAAUGGCUGATTUCAGCCAUUGUGUAUUUAGTT 13429.2S997 AUACACAAUGGCUGAUUUATTUAAAUCAGCCAUUGUGUAUTT 13414.1S998 UACACAAUGGCUGAUUUAGTTCUAAAUCAGCCAUUGUGUATT 13429.2S999 AAGAAAUACUCGUCACAUATTUAUGUGACGAGUAUUUCUUTT 13414.1S1000 AGAAAUACUCGUCACAUACTTGUAUGUGACGAGUAUUUCUTT 13429.2S1001 GAAAUACUCGUCACAUACATTUGUAUGUGACGAGUAUUUCTT 13429.2S1002 AUACUCGUCACAUACAAUUTTAAUUGUAUGUGACGAGUAUTT 13414.1S1003 UACUCGUCACAUACAAUUGTTCAAUUGUAUGUGACGAGUATT 13429.2S1004 UUGCUGUGAUGAUGAUUAUTTAUAAUCAUCAUCACAGCAATT 13414.1S1005 UAAGAAGGAUUGGUAUGACTTGUCAUACCAAUCCUUCUUATT 13429.2S1006 AGACUGUACAAUUCUGCGATTUCGCAGAAUUGUACAGUCUTT 13444.3S1007 UCAGGAUCUUAAUGGGAACTTGUUCCCAUUAAGAUCCUGATT 13444.3S1008 UGGGAACUGGUACGAUUUCTTGAAAUCGUACCAGUUCCCATT 13459.4S1009 GUAGCACCAGGCUGCGGAGTTCUCCGCAGCCUGGUGCUACTT 13519.8S1010 AACCACUUAUUAAGUGGGATTUCCCACUUAAUAAGUGGUUTT 13429.2S1011 ACCACUUAUUAAGUGGGAUTTAUCCCACUUAAUAAGUGGUTT 13429.2S1012 CCACUUAUUAAGUGGGAUUTTAAUCCCACUUAAUAAGUGGTT 13429.2S1013 GUGGGAUUUGCUGAAAUAUTTAUAUUUCAGCAAAUCCCACTT 13429.2S1014 AUAUGAUUUUACGGAAGAGTTCUCUUCCGUAAAAUCAUAUTT 13414.1S1015 UAUGAUUUUACGGAAGAGATTUCUCUUCCGUAAAAUCAUATT 13414.1S1016 AUAUUGGGACCAGACAUACTTGUAUGUCUGGUCCCAAUAUTT 13444.3S1017 UAUUGGGACCAGACAUACCTTGGUAUGUCUGGUCCCAAUATT 13459.4S1018 UGUGUUAUUUUCUACUGUGTTCACAGUAGAAAAUAACACATT 13414.1S1019 GUUUUGGACCACUAGUAAGTTCUUACUAGUGGUCCAAAACTT 13444.3S1020 AUAUUUGUAGAUGGUGUUCTTGAACACCAUCUACAAAUAUTT 13414.1S1021 UAUUUGUAGAUGGUGUUCCTTGGAACACCAUCUACAAAUATT 13429.2S1022 CUGGAUACCAUUUUCGUGATTUCACGAAAAUGGUAUCCAGTT 13444.3
S1023UCAGGAUGUAAACUUACAUTT AUGUAAGUUUACAUCCUGATT 13414.1S1024ACUUACAUAGCUCGCGUCUTT AGACGCGAGCUAUGUAAGUTT 13459.4S1025GGAACUUUUAGUGUAUGCUTT AGCAUACACUAAAAGUUCCTT 13429.2S1026CUUUUAGUGUAUGCUGCUGTT CAGCAGCAUACACUAAAAGTT 13444.3S1027UUUAUUGCUAGAUAAACGCTT GCGUUUAUCUAGCAAUAAATT 13414.1S1028ACGCACUACAUGCUUUUCATT UGAAAAGCAUGUAGUGCGUTT 13444.3S1029CGCACUACAUGCUUUUCAGTT CUGAAAAGCAUGUAGUGCGTT 13459.4S1030CAAACAAUGUUGCUUUUCATT UGAAAAGCAACAUUGUUUGTT 13414.1S1031ACAAUGUUGCUUUUCAAACTT GUUUGAAAAGCAACAUUGUTT 13414.1S1032CAAUGUUGCUUUUCAAACUTT AGUUUGAAAAGCAACAUUGTT 13414.1S1033UGUUGCUUUUCAAACUGUCTT GACAGUUUGAAAAGCAACATT 13429.2S1034ACUGUCAAACCCGGUAAUUTT AAUUACCGGGUUUGACAGUTT 13444.3S1035CUGUCAAACCCGGUAAUUUTT AAAUUACCGGGUUUGACAGTT 13444.3S1036CCCGGUAAUUUUAAUAAAGTT CUUUAUUAAAAUUACCGGGTT 13414.1S1037AGACUUUUAUGACUUUGCUTT AGCAAAGUCAUAAAAGUCUTT 13414.1S1038GACUUUUAUGACUUUGCUGTT CAGCAAAGUCAUAAAAGUCTT 13429.2S1039AGGUUUCUUUAAGGAAGGATT UCCUUCCUUAAAGAAACCUTT 13429.2S1040GGUUUCUUUAAGGAAGGAATT UUCCUUCCUUAAAGAAACCTT 13429.2S1041GGAAGUUCUGUUGAACUAATT UUAGUUCAACAGAACUUCCTT 13429.2S1042GUUCUGUUGAACUAAAACATT UGUUUUAGUUCAACAGAACTT 13414.1S1043CUAAAACACUUCUUCUUUGTT CAAAGAAGAAGUGUUUUAGTT 13414.1S1044AACACUUCUUCUUUGCUCATT UGAGCAAAGAAGAAGUGUUTT 13429.2S1045ACACUUCUUCUUUGCUCAGTT CUGAGCAAAGAAGAAGUGUTT 13444.3S1046CAAUGUGUGAUAUCAGACATT UGUCUGAUAUCACACAUUGTT 13429.2S1047UGUGUGAUAUCAGACAACUTT AGUUGUCUGAUAUCACACATT 13429.2S1048UACUUUGAUUGUUACGAUGTT CAUCGUAACAAUCAAAGUATT 13414.1S1049CCAAGUAAUCGUUAACAAUTT AUUGUUAACGAUUACUUGGTT 13414.1S1050GUAAUCGUUAACAAUCUGGTT CCAGAUUGUUAACGAUUACTT 13429.2S1051UCGUUAACAAUCUGGAUAATT UUAUCCAGAUUGUUAACGATT 13414.1S1052CAAUCUGGAUAAAUCAGCUTT AGCUGAUUUAUCCAGAUUGTT 13429.2S1053AUCAGCUGGUUUCCCAUUUTT AAAUGGGAAACCAGCUGAUTT 13444.3S1054UCAGCUGGUUUCCCAUUUATT UAAAUGGGAAACCAGCUGATT 13444.3S1055UAAAUGGGGUAAGGCUAGATT UCUAGCCUUACCCCAUUUATT 13444.3S1056AUGGGGUAAGGCUAGACUUTT AAGUCUAGCCUUACCCCAUTT 13459.4
S1057UGGGGUAAGGCUAGACUUUTT AAAGUCUAGCCUUACCCCATT 13459.4S1058GGCUAGACUUUAUUAUGACTT GUCAUAAUAAAGUCUAGCCTT 13429.2S1059UGAGUUAUGAGGAUCAAGATT UCUUGAUCCUCAUAACUCATT 13429.2S1060GAUGCACUUUUCGCGUAUATT UAUACGCGAAAAGUGCAUCTT 13444.3S1061GCGUAAUGUCAUCCCUACUTT AGUAGGGAUGACAUUACGCTT 13459.4S1062UGUCAUCCCUACUAUAACUTT AGUUAUAGUAGGGAUGACATT 13429.2S1063AUGAAUCUUAAGUAUGCCATT UGGCAUACUUAAGAUUCAUTT 13414.1S1064UGAAUCUUAAGUAUGCCAUTT AUGGCAUACUUAAGAUUCATT 13414.1S1065UCUUAAGUAUGCCAUUAGUTT ACUAAUGGCAUACUUAAGATT 13414.1S1066AGAAUAGAGCUCGCACCGUTT ACGGUGCGAGCUCUAUUCUTT 13474.5S1067AUAGACAGUUUCAUCAGAATT UUCUGAUGAAACUGUCUAUTT 13414.1S1068UAGACAGUUUCAUCAGAAATT UUUCUGAUGAAACUGUCUATT 13414.1S1069AUUAUUGAAGUCAAUAGCCTT GGCUAUUGACUUCAAUAAUTT 13414.1S1070UUAUUGAAGUCAAUAGCCGTT CGGCUAUUGACUUCAAUAATT 13429.2S1071UAGCCGCCACUAGAGGAGCTT GCUCCUCUAGUGGCGGCUATT 13504.7S1072UUGGAACAAGCAAGUUUUATT UAAAACUUGCUUGUUCCAATT 13414.1S1073CAAGCAAGUUUUACGGUGGTT CCACCGUAAAACUUGCUUGTT 13459.4S1074GCAAGUUUUACGGUGGCUGTT CAGCCACCGUAAAACUUGCTT 13474.5S1075GUUUUACGGUGGCUGGCAUTT AUGCCAGCCACCGUAAAACTT 13474.5S1076AAACUGUUUACAGUGAUGUTT ACAUCACUGUAAACAGUUUTT 13414.1S1077AACUGUUUACAGUGAUGUATT UACAUCACUGUAAACAGUUTT 13414.1S1078ACUGUUUACAGUGAUGUAGTT CUACAUCACUGUAAACAGUTT 13429.2S1079CUGUUUACAGUGAUGUAGATT UCUACAUCACUGUAAACAGTT 13429.2S1080CUCCACACCUUAUGGGUUGTT CAACCCAUAAGGUGUGGAGTT 13474.5S1081AAUGUGACAGAGCCAUGCCTT GGCAUGGCUCUGUCACAUUTT 13474.5S1082AUGUGACAGAGCCAUGCCUTT AGGCAUGGCUCUGUCACAUTT 13474.5S1083ACAUAACACUUGCUGUAACTT GUUACAGCAAGUGUUAUGUTT 13429.2S1084CAUAACACUUGCUGUAACUTT AGUUACAGCAAGUGUUAUGTT 13429.2S1085CACUUGCUGUAACUUAUCATT UGAUAAGUUACAGCAAGUGTT 13429.2S1086GUAUUAAGUGAGAUGGUCATT UGACCAUCUCACUUAAUACTT 13429.2S1087ACCAGGUGGAACAUCAUCCTT GGAUGAUGUUCCACCUGGUTT 13474.5S1088CUGCUUAUGCUAAUAGUGUTT ACACUAUUAGCAUAAGCAGTT 13429.2S1089CAUUUGUCAAGCUGUUACATT UGUAACAGCUUGACAAAUGTT 13429.2S1090UGUAAAUGCACUUCUUUCATT UGAAAGAAGUGCAUUUACATT 13414.1
S1091 AUGCACUUCUUUCAACUGATT UCAGUUGAAAGAAGUGCAUTT 13429.2S1092 UGCACUUCUUUCAACUGAUTT AUCAGUUGAAAGAAGUGCATT 13429.2S1093 CUGAUGGUAAUAAGAUAGCTT GCUAUCUUAUUACCAUCAGTT 13429.2S1094 AUAGGGAUGUUGAUCAUGATT UCAUGAUCAACAUCCCUAUTT 13429.2S1095 UAGGGAUGUUGAUCAUGAATT UUCAUGAUCAACAUCCCUATT 13429.2S1096 UUCGUGGAUGAGUUUUACGTT CGUAAAACUCAUCCACGAATT 13444.3S1097 ACAUUUCUCCAUGAUGAUUTT AAUCAUCAUGGAGAAAUGUTT 13414.1S1098 CAUUUCUCCAUGAUGAUUCTT GAAUCAUCAUGGAGAAAUGTT 13429.2S1099 GGUUUAGUAGCUAGCAUUATT UAAUGCUAGCUACUAAACCTT 13429.2S1100 GAACUUUAAGGCAGUUCUUTT AAGAACUGCCUUAAAGUUCTT 13429.2S1101 CUUUAAGGCAGUUCUUUAUTT AUAAAGAACUGCCUUAAAGTT 13414.1S1102 GGCAGUUCUUUAUUAUCAATT UUGAUAAUAAAGAACUGCCTT 13414.1S1103 AAUAAUGUGUUCAUGUCUGTT CAGACAUGAACACAUUAUUTT 13414.1S1104 AUAAUGUGUUCAUGUCUGATT UCAGACAUGAACACAUUAUTT 13414.1S1105 UAAUGUGUUCAUGUCUGAGTT CUCAGACAUGAACACAUUATT 13429.2S1106 AAUGUUGGACUGAGACUGATT UCAGUCUCAGUCCAACAUUTT 13444.3S1107 AUGUUGGACUGAGACUGACTT GUCAGUCUCAGUCCAACAUTT 13459.4S1108 AGGACCUCACGAAUUUUGCTT GCAAAAUUCGUGAGGUCCUTT 13459.4S1109 GGACCUCACGAAUUUUGCUTT AGCAAAAUUCGUGAGGUCCTT 13459.4S1110 UUUUGCUCACAGCAUACAATT UUGUAUGCUGUGAGCAAAATT 13429.2S1111 UGCUAGUUAAACAAGGAGATT UCUCCUUGUUUAACUAGCATT 13429.2S1112 ACAAGGAGAUGAUUACGUGTT CACGUAAUCAUCUCCUUGUTT 13444.3S1113 AACAGAUGGUACACUUAUGTT CAUAAGUGUACCAUCUGUUTT 13429.2S1114 ACAGAUGGUACACUUAUGATT UCAUAAGUGUACCAUCUGUTT 13429.2S1115 CAGAUGGUACACUUAUGAUTT AUCAUAAGUGUACCAUCUGTT 13429.2S1116 AGGUUCGUGUCACUGGCUATT UAGCCAGUGACACGAACCUTT 13474.5S1117 AACAUCCUAAUCAGGAGUATT UACUCCUGAUUAGGAUGUUTT 13429.2S1118 ACAUCCUAAUCAGGAGUAUTT AUACUCCUGAUUAGGAUGUTT 13429.2S1119 UCAGGAGUAUGCUGAUGUCTT GACAUCAGCAUACUCCUGATT 13459.4S1120 AGUUACAUGAUGAGCUUACTT GUAAGCUCAUCAUGUAACUTT 13429.2S1121 GUUACAUGAUGAGCUUACUTT AGUAAGCUCAUCAUGUAACTT 13429.2S1122 UGCUAACUAAUGAUAACACTT GUGUUAUCAUUAGUUAGCATT 13414.1S1123 CACCUCACGGUACUGGGAATT UUCCCAGUACCGUGAGGUGTT 13489.6S1124 CCUGAGUUUUAUGAGGCUATT UAGCCUCAUAAAACUCAGGTT 13444.3
S1125CAUCACACAAAUUAGUGUUTT AACACUAAUUUGUGUGAUGTT 13414.1S1126UUAGUGUUGUCUGUUAAUCTT GAUUAACAGACAACACUAATT 13414.1S1127UCCCUAUGUUUGCAAUGCCTT GGCAUUGCAAACAUAGGGATT 13459.4S1128UGCCCCAGGUUGUGAUGUCTT GACAUCACAACCUGGGGCATT 13489.6S1129GUCACAUAAGCCUCCCAUUTT AAUGGGAGGCUUAUGUGACTT 13459.4S1130GCCUCCCAUUAGUUUUCCATT UGGAAAACUAAUGGGAGGCTT 13459.4S1131UGGUCAGGUUUUUGGUUUATT UAAACCAAAAACCUGACCATT 13429.2S1132AAACACAUGUGUAGGCAGUTT ACUGCCUACACAUGUGUUUTT 13444.3S1133AACACAUGUGUAGGCAGUGTT CACUGCCUACACAUGUGUUTT 13459.4S1134ACACAUGUGUAGGCAGUGATT UCACUGCCUACACAUGUGUTT 13459.4S1135CACAUGUGUAGGCAGUGACTT GUCACUGCCUACACAUGUGTT 13474.5S1136UGUCACUGACUUCAAUGCGTT CGCAUUGAAGUCAGUGACATT 13459.4S1137UGCGAUAGCAACAUGUGAUTT AUCACAUGUUGCUAUCGCATT 13444.3S1138CAUGUGAUUGGACUAAUGCTT GCAUUAGUCCAAUCACAUGTT 13444.3S1139UGCUGGCGAUUACAUACUUTT AAGUAUGUAAUCGCCAGCATT 13444.3S1140CACUUGUACUGAGAGACUCTT GAGUCUCUCAGUACAAGUGTT 13459.4S1141GCUUUUCGCAGCAGAAACGTT CGUUUCUGCUGCGAAAAGCTT 13474.5S1142ACGCUCAAAGCCACUGAGGTT CCUCAGUGGCUUUGAGCGUTT 13489.6S1143CGCUCAAAGCCACUGAGGATT UCCUCAGUGGCUUUGAGCGTT 13489.6S1144AGCCACUGAGGAAACAUUUTT AAAUGUUUCCUCAGUGGCUTT 13444.3S1145GCCACUGAGGAAACAUUUATT UAAAUGUUUCCUCAGUGGCTT 13444.3S1146ACAUUUAAGCUGUCAUAUGTT CAUAUGACAGCUUAAAUGUTT 13414.1S1147CAUUUAAGCUGUCAUAUGGTT CCAUAUGACAGCUUAAAUGTT 13429.2S1148GCUGUCAUAUGGUAUUGCCTT GGCAAUACCAUAUGACAGCTT 13459.4S1149GUACUCUCUGACAGAGAAUTT AUUCUCUGUCAGAGAGUACTT 13444.3S1150UUGCAUCUUUCAUGGGAGGTT CCUCCCAUGAAAGAUGCAATT 13459.4S1151AACCUAGACCACCAUUGAATT UUCAAUGGUGGUCUAGGUUTT 13444.3S1152ACCUAGACCACCAUUGAACTT GUUCAAUGGUGGUCUAGGUTT 13459.4S1153CCUAGACCACCAUUGAACATT UGUUCAAUGGUGGUCUAGGTT 13459.4S1154CAGAAACUAUGUCUUUACUTT AGUAAAGACAUAGUUUCUGTT 13414.1S1155ACUAUGUCUUUACUGGUUATT UAACCAGUAAAGACAUAGUTT 13414.1S1156CUAUGUCUUUACUGGUUACTT GUAACCAGUAAAGACAUAGTT 13429.2S1157AUAGUAAAGUACAGAUUGGTT CCAAUCUGUACUUUACUAUTT 13414.1S1158UAGUAAAGUACAGAUUGGATT UCCAAUCUGUACUUUACUATT 13414.1
S1159AGUACAGAUUGGAGAGUACTT GUACUCUCCAAUCUGUACUTT 13444.3S1160GUACAGAUUGGAGAGUACATT UGUACUCUCCAAUCUGUACTT 13444.3S1161AAAGGUGACUAUGGUGAUGTT CAUCACCAUAGUCACCUUUTT 13444.3S1162AAGGUGACUAUGGUGAUGCTT GCAUCACCAUAGUCACCUUTT 13459.4S1163AGGUGACUAUGGUGAUGCUTT AGCAUCACCAUAGUCACCUTT 13459.4S1164GGUGACUAUGGUGAUGCUGTT CAGCAUCACCAUAGUCACCTT 13474.5S1165GUUGAAUGUUGGUGAUUACTT GUAAUCACCAACAUUCAACTT 13429.2S1166UGUUGGUGAUUACUUUGUGTT CACAAAGUAAUCACCAACATT 13429.2S1167UGCCACUUAGUGCACCUACTT GUAGGUGCACUAAGUGGCATT 13474.5S1168GAGCACUAUGUGAGAAUUATT UAAUUCUCACAUAGUGCUCTT 13429.2S1169UUACUGGCUUGUACCCAACTT GUUGGGUACAAGCCAGUAATT 13459.4S1170CACUCAACAUCUCAGAUGATT UCAUCUGAGAUGUUGAGUGTT 13444.3S1171CAUCUCAGAUGAGUUUUCUTT AGAAAACUCAUCUGAGAUGTT 13429.2S1172AUUAUCAAAAGGUCGGCAUTT AUGCCGACCUUUUGAUAAUTT 13429.2S1173UUAUCAAAAGGUCGGCAUGTT CAUGCCGACCUUUUGAUAATT 13444.3S1174AAGGUCGGCAUGCAAAAGUTT ACUUUUGCAUGCCGACCUUTT 13459.4S1175AGGUCGGCAUGCAAAAGUATT UACUUUUGCAUGCCGACCUTT 13459.4S1176GGUCGGCAUGCAAAAGUACTT GUACUUUUGCAUGCCGACCTT 13474.5S1177AAGUACUCUACACUCCAAGTT CUUGGAGUGUAGAGUACUUTT 13444.3S1178AGUACUCUACACUCCAAGGTT CCUUGGAGUGUAGAGUACUTT 13459.4S1179GUACUCUACACUCCAAGGATT UCCUUGGAGUGUAGAGUACTT 13459.4S1180GGACCACCUGGUACUGGUATT UACCAGUACCAGGUGGUCCTT 13489.6S1181GAGUCAUUUUGCCAUCGGATT UCCGAUGGCAAAAUGACUCTT 13459.4S1182AGGCAUUAAAAUAUUUGCCTT GGCAAAUAUUUUAAUGCCUTT 13414.1S1183GGCAUUAAAAUAUUUGCCCTT GGGCAAAUAUUUUAAUGCCTT 13429.2S1184AUGUAGUAGAAUCAUACCUTT AGGUAUGAUUCUACUACAUTT 13414.1S1185UGUAGUAGAAUCAUACCUGTT CAGGUAUGAUUCUACUACATT 13429.2S1186UCAUACCUGCGCGUGCGCGTT CGCGCACGCGCAGGUAUGATT 13519.8S1187UUCAAAGUGAAUUCAACACTT GUGUUGAAUUCACUUUGAATT 13414.1S1188AGUGAAUUCAACACUAGAATT UUCUAGUGUUGAAUUCACUTT 13414.1S1189GUGAAUUCAACACUAGAACTT GUUCUAGUGUUGAAUUCACTT 13429.2S1190UUCAACACUAGAACAGUAUTT AUACUGUUCUAGUGUUGAATT 13414.1S1191CACUAGAACAGUAUGUUUUTT AAAACAUACUGUUCUAGUGTT 13414.1S1192CAGUAUGUUUUCUGCACUGTT CAGUGCAGAAAACAUACUGTT 13444.3
S1193AUGCAUUGCCAGAAACAACTT GUUGUUUCUGGCAAUGCAUTT 13444.3S1194UGCAUUGCCAGAAACAACUTT AGUUGUUUCUGGCAAUGCATT 13444.3S1195ACAACUGCUGACAUUGUAGTT CUACAAUGUCAGCAGUUGUTT 13444.3S1196CAACUGCUGACAUUGUAGUTT ACUACAAUGUCAGCAGUUGTT 13444.3S1197CUGCUGACAUUGUAGUCUUTT AAGACUACAAUGUCAGCAGTT 13444.3S1198AUCUCUAUGGCUACUAAUUTT AAUUAGUAGCCAUAGAGAUTT 13414.1S1199UCUCUAUGGCUACUAAUUATT UAAUUAGUAGCCAUAGAGATT 13414.1S1200UUAUGACUUGAGUGUUGUCTT GACAACACUCAAGUCAUAATT 13429.2S1201UGCUAGACUUCGUGCAAAATT UUUUGCACGAAGUCUAGCATT 13444.3S1202AACACUACGUCUAUAUUGGTT CCAAUAUAGACGUAGUGUUTT 13429.2S1203ACACUACGUCUAUAUUGGCTT GCCAAUAUAGACGUAGUGUTT 13444.3S1204CACUACGUCUAUAUUGGCGTT CGCCAAUAUAGACGUAGUGTT 13459.4S1205UUACCAGCCCCCCGCACAUTT AUGUGCGGGGGGCUGGUAATT 13504.7S1206AGGCACACUAGAACCAGAATT UUCUGGUUCUAGUGUGCCUTT 13459.4S1207GGCACACUAGAACCAGAAUTT AUUCUGGUUCUAGUGUGCCTT 13459.4S1208UUCAGUGUGCAGACUUAUGTT CAUAAGUCUGCACACUGAATT 13444.3S1209AACAAUAGGUCCAGACAUGTT CAUGUCUGGACCUAUUGUUTT 13444.3S1210ACAAUAGGUCCAGACAUGUTT ACAUGUCUGGACCUAUUGUTT 13444.3S1211CAAUAGGUCCAGACAUGUUTT AACAUGUCUGGACCUAUUGTT 13444.3S1212UAGGUCCAGACAUGUUCCUTT AGGAACAUGUCUGGACCUATT 13459.4S1213CUUGUCGCCGUUGUCCUGCTT GCAGGACAACGGCGACAAGTT 13504.7S1214AUUGUUGACACUGUGAGUGTT CACUCACAGUGUCAACAAUTT 13444.3S1215UUGUUGACACUGUGAGUGCTT GCACUCACAGUGUCAACAATT 13459.4S1216UAAGCUAAAAGCACACAAGTT CUUGUGUGCUUUUAGCUUATT 13429.2S1217GCUAAAAGCACACAAGGAUTT AUCCUUGUGUGCUUUUAGCTT 13444.3S1218AAGCACACAAGGAUAAGUCTT GACUUAUCCUUGUGUGCUUTT 13444.3S1219AGCACACAAGGAUAAGUCATT UGACUUAUCCUUGUGUGCUTT 13444.3S1220GCACACAAGGAUAAGUCAGTT CUGACUUAUCCUUGUGUGCTT 13459.4S1221GGAUAAGUCAGCUCAAUGCTT GCAUUGAGCUGACUUAUCCTT 13459.4S1222GUCAGCUCAAUGCUUCAAATT UUUGAAGCAUUGAGCUGACTT 13444.3S1223UGCUUCAAAAUGUUCUACATT UGUAGAACAUUUUGAAGCATT 13414.1S1224AAUGUUCUACAAAGGUGUUTT AACACCUUUGUAGAACAUUTT 13414.1S1225AUGUUCUACAAAGGUGUUATT UAACACCUUUGUAGAACAUTT 13414.1S1226UGUUCUACAAAGGUGUUAUTT AUAACACCUUUGUAGAACATT 13414.1
S1227 AGGUGUUAUUACACAUGAUTTAUCAUGUGUAAUAACACCUTT 13414.1S1228 GGUGUUAUUACACAUGAUGTTCAUCAUGUGUAAUAACACCTT 13429.2S1229 UCAACAGACCUCAAAUAGGTTCCUAUUUGAGGUCUGUUGATT 13444.3S1230 CAGACCUCAAAUAGGCGUUTTAACGCCUAUUUGAGGUCUGTT 13459.4S1231 AUAGGCGUUGUAAGAGAAUTTAUUCUCUUACAACGCCUAUTT 13429.2S1232 UAGGCGUUGUAAGAGAAUUTTAAUUCUCUUACAACGCCUATT 13429.2S1233 GAGAAUUUCUUACACGCAATTUUGCGUGUAAGAAAUUCUCTT 13429.2S1234 UUUCUUACACGCAAUCCUGTTCAGGAUUGCGUGUAAGAAATT 13444.3S1235 UCCUGCUUGGAGAAAAGCUTTAGCUUUUCUCCAAGCAGGATT 13459.4S1236 AAGCUGUUUUUAUCUCACCTTGGUGAGAUAAAAACAGCUUTT 13429.2S1237 AGCUGUUUUUAUCUCACCUTTAGGUGAGAUAAAAACAGCUTT 13429.2S1238 GCUGUUUUUAUCUCACCUUTTAAGGUGAGAUAAAAACAGCTT 13429.2S1239 UUCACAGAACGCUGUAGCUTTAGCUACAGCGUUCUGUGAATT 13459.4S1240 CGCUGUAGCUUCAAAAAUCTTGAUUUUUGAAGCUACAGCGTT 13444.3S1241 AAAUCUUAGGAUUGCCUACTTGUAGGCAAUCCUAAGAUUUTT 13429.2S1242 AAUCUUAGGAUUGCCUACGTTCGUAGGCAAUCCUAAGAUUTT 13444.3S1243 AUCUUAGGAUUGCCUACGCTTGCGUAGGCAAUCCUAAGAUTT 13459.4S1244 UCUUAGGAUUGCCUACGCATTUGCGUAGGCAAUCCUAAGATT 13459.4S1245 ACUACUGAAACAGCACACUTTAGUGUGCUGUUUCAGUAGUTT 13444.3S1246 CUACUGAAACAGCACACUCTTGAGUGUGCUGUUUCAGUAGTT 13459.4S1247 ACAGCACACUCUUGUAAUGTTCAUUACAAGAGUGUGCUGUTT 13444.3S1248 CAGCACACUCUUGUAAUGUTTACAUUACAAGAGUGUGCUGTT 13444.3S1249 UGUCAACCGCUUCAAUGUGTTCACAUUGAAGCGGUUGACATT 13459.4S1250 CCGCUUCAAUGUGGCUAUCTTGAUAGCCACAUUGAAGCGGTT 13474.5S1251 UGUGGCUAUCACAAGGGCATTUGCCCUUGUGAUAGCCACATT 13474.5S1252 GGGCAAAAAUUGGCAUUUUTTAAAAUGCCAAUUUUUGCCCTT 13429.2S1253 AAAUUGGCAUUUUGUGCAUTTAUGCACAAAAUGCCAAUUUTT 13414.1S1254 AAUUGGCAUUUUGUGCAUATTUAUGCACAAAAUGCCAAUUTT 13414.1S1255 AUUGGCAUUUUGUGCAUAATTUUAUGCACAAAAUGCCAAUTT 13414.1S1256 UUGGCAUUUUGUGCAUAAUTTAUUAUGCACAAAAUGCCAATT 13414.1S1257 UGUCUGAUAGAGAUCUUUATTUAAAGAUCUCUAUCAGACATT 13414.1S1258 ACUGCAAUUUACAAGUCUATTUAGACUUGUAAAUUGCAGUTT 13414.1S1259 CUGCAAUUUACAAGUCUAGTTCUAGACUUGUAAAUUGCAGTT 13429.2S1260 GUCUAGAAAUACCACGUCGTTCGACGUGGUAUUUCUAGACTT 13459.4
S1261 AUACCACGUCGCAAUGUGGTT CCACAUUGCGACGUGGUAUTT 13474.5S1262 UACCACGUCGCAAUGUGGCTT GCCACAUUGCGACGUGGUATT 13489.6S1263 UGUGGCUACAUUACAAGCATT UGCUUGUAAUGUAGCCACATT 13444.3S1264 GCAGAAAAUGUAACUGGACTT GUCCAGUUACAUUUUCUGCTT 13444.3S1265 UGUAACUGGACUUUUUAAGTT CUUAAAAAGUCCAGUUACATT 13414.1S1266 CUGGACUUUUUAAGGACUGTT CAGUCCUUAAAAAGUCCAGTT 13444.3S1267 GGACUGUAGUAAGAUCAUUTT AAUGAUCUUACUACAGUCCTT 13429.2S1268 GAUCAUUACUGGUCUUCAUTT AUGAAGACCAGUAAUGAUCTT 13429.2S1269 AGUUCAAGACUGAAGGAUUTT AAUCCUUCAGUCUUGAACUTT 13429.2S1270 GUUCAAGACUGAAGGAUUATT UAAUCCUUCAGUCUUGAACTT 13429.2S1271 GACUGAAGGAUUAUGUGUUTT AACACAUAAUCCUUCAGUCTT 13429.2S1272 GGAUUAUGUGUUGACAUACTT GUAUGUCAACACAUAAUCCTT 13429.2S1273 AGGACAUGACCUACCGUAGTT CUACGGUAGGUCAUGUCCUTT 13474.5S1274 GGACAUGACCUACCGUAGATT UCUACGGUAGGUCAUGUCCTT 13474.5S1275 AUGAAUUACCAAGUCAAUGTT CAUUGACUUGGUAAUUCAUTT 13414.1S1276 UGAAUUACCAAGUCAAUGGTT CCAUUGACUUGGUAAUUCATT 13429.2S1277 UUACCAAGUCAAUGGUUACTT GUAACCAUUGACUUGGUAATT 13429.2S1278 GUCAAUGGUUACCCUAAUATT UAUUAGGGUAACCAUUGACTT 13429.2S1279 UGGUUACCCUAAUAUGUUUTT AAACAUAUUAGGGUAACCATT 13414.1S1280 UAUGUUUAUCACCCGCGAATT UUCGCGGGUGAUAAACAUATT 13444.3S1281 GAAGCUAUUCGUCACGUUCTT GAACGUGACGAAUAGCUUCTT 13459.4S1282 GCUAUUCGUCACGUUCGUGTT CACGAACGUGACGAAUAGCTT 13474.5S1283 CUAGAGAUGCUGUGGGUACTT GUACCCACAGCAUCUCUAGTT 13474.5S1284 CUUAGUAGCUGUACCGACUTT AGUCGGUACAGCUACUAAGTT 13459.4S1285 AAUAACACAGAAUUCACCATT UGGUGAAUUCUGUGUUAUUTT 13414.1S1286 AUAACACAGAAUUCACCAGTT CUGGUGAAUUCUGUGUUAUTT 13429.2S1287 UAACACAGAAUUCACCAGATT UCUGGUGAAUUCUGUGUUATT 13429.2S1288 CACAGAAUUCACCAGAGUUTT AACUCUGGUGAAUUCUGUGTT 13444.3S1289 UUCACCAGAGUUAAUGCAATT UUGCAUUAACUCUGGUGAATT 13429.2S1290 UGCAAAACCUCCACCAGGUTT ACCUGGUGGAGGUUUUGCATT 13474.5S1291 AACCUCCACCAGGUGACCATT UGGUCACCUGGUGGAGGUUTT 13489.6S1292 ACCUCCACCAGGUGACCAGTT CUGGUCACCUGGUGGAGGUTT 13504.7S1293 CCUCCACCAGGUGACCAGUTT ACUGGUCACCUGGUGGAGGTT 13504.7S1294 ACAUCUUAUACCACUCAUGTT CAUGAGUGGUAUAAGAUGUTT 13429.2
S1295CAUCUUAUACCACUCAUGUTT ACAUGAGUGGUAUAAGAUGTT 13429.2S1296AGGCUUGCCCUGGAAUGUATT UACAUUCCAGGGCAAGCCUTT 13474.5S1297GGCUUGCCCUGGAAUGUAGTT CUACAUUCCAGGGCAAGCCTT 13489.6S1298UGUAGUGCGUAUUAAGAUATT UAUCUUAAUACGCACUACATT 13414.1S1299GAUAGUACAAAUGCUCAGUTT ACUGAGCAUUUGUACUAUCTT 13429.2S1300AUGCUCAGUGAUACACUGATT UCAGUGUAUCACUGAGCAUTT 13444.3S1301UGCUCAGUGAUACACUGAATT UUCAGUGUAUCACUGAGCATT 13444.3S1302AGGAUUGUCAGACAGAGUCTT GACUCUGUCUGACAAUCCUTT 13459.4S1303GGAUUGUCAGACAGAGUCGTT CGACUCUGUCUGACAAUCCTT 13474.5S1304UGAAGUACUUUGUCAAGAUTT AUCUUGACAAAGUACUUCATT 13414.1S1305GUACUUUGUCAAGAUUGGATT UCCAAUCUUGACAAAGUACTT 13429.2S1306GAUUGGACCUGAAAGAACGTT CGUUCUUUCAGGUCCAAUCTT 13459.4S1307AGAACGUGUUGUCUGUGUGTT CACACAGACAACACGUUCUTT 13459.4S1308GAACGUGUUGUCUGUGUGATT UCACACAGACAACACGUUCTT 13459.4S1309CGUGUUGUCUGUGUGACAATT UUGUCACACAGACAACACGTT 13459.4S1310ACGUGCAACUUGCUUUUCUTT AGAAAAGCAAGUUGCACGUTT 13444.3S1311CGUGCAACUUGCUUUUCUATT UAGAAAAGCAAGUUGCACGTT 13444.3S1312CUUGCUUUUCUACUUCAUCTT GAUGAAGUAGAAAAGCAAGTT 13429.2S1313UCAUUCUGUGGGUUUUGACTT GUCAAAACCCACAGAAUGATT 13444.3S1314CCCAUUUAUGAUUGAUGUUTT AACAUCAAUCAUAAAUGGGTT 13414.1S1315CCUUCAGAGUAACCAUGACTT GUCAUGGUUACUCUGAAGGTT 13459.4S1316CCAUGACCAACAUUGCCAGTT CUGGCAAUGUUGGUCAUGGTT 13474.5S1317CAUUGCCAGGUACAUGGAATT UUCCAUGUACCUGGCAAUGTT 13459.4S1318AUGCACAUGUGGCUAGUUGTT CAACUAGCCACAUGUGCAUTT 13459.4S1319UGCACAUGUGGCUAGUUGUTT ACAACUAGCCACAUGUGCATT 13459.4S1320GCGCGUUGAUUGGUCUGUUTT AACAGACCAAUCAACGCGCTT 13474.5S1321UACCCUAUUAUAGGAGAUGTT CAUCUCCUAUAAUAGGGUATT 13429.2S1322CUGAGGGUUAAUUCUGCUUTT AAGCAGAAUUAACCCUCAGTT 13444.3S1323UUCUGCUUGCAGAAAAGUATT UACUUUUCUGCAAGCAGAATT 13429.2S1324AAGUACAACACAUGGUUGUTT ACAACCAUGUGUUGUACUUTT 13429.2S1325AGUACAACACAUGGUUGUGTT CACAACCAUGUGUUGUACUTT 13444.3S1326GUACAACACAUGGUUGUGATT UCACAACCAUGUGUUGUACTT 13444.3S1327CACAUGGUUGUGAAGUCUGTT CAGACUUCACAACCAUGUGTT 13459.4S1328GUCUGCAUUGCUUGCUGAUTT AUCAGCAAGCAAUGCAGACTT 13459.4
S1329GUUUCCAGUUCUUCAUGACTT GUCAUGAAGAACUGGAAACTT 13444.3S1330AUCCAAAGGCUAUCAAGUGTT CACUUGAUAGCCUUUGGAUTT 13444.3S1331UCCAAAGGCUAUCAAGUGUTT ACACUUGAUAGCCUUUGGATT 13444.3S1332AGGCUAUCAAGUGUGUGCCTT GGCACACACUUGAUAGCCUTT 13474.5S1333GGCUAUCAAGUGUGUGCCUTT AGGCACACACUUGAUAGCCTT 13474.5S1334GUGUGUGCCUCAGGCUGAATT UUCAGCCUGAGGCACACACTT 13489.6S1335GUAGAAUGGAAGUUCUACGTT CGUAGAACUUCCAUUCUACTT 13444.3S1336UGGAAGUUCUACGAUGCUCTT GAGCAUCGUAGAACUUCCATT 13459.4S1337GUUCUACGAUGCUCAGCCATT UGGCUGAGCAUCGUAGAACTT 13474.5S1338AGCUUACAAAAUAGAGGAATT UUCCUCUAUUUUGUAAGCUTT 13414.1S1339GCUUACAAAAUAGAGGAACTT GUUCCUCUAUUUUGUAAGCTT 13429.2S1340AAUAGAGGAACUCUUCUAUTT AUAGAAGAGUUCCUCUAUUTT 13414.1S1341AUAGAGGAACUCUUCUAUUTT AAUAGAAGAGUUCCUCUAUTT 13414.1S1342UAGAGGAACUCUUCUAUUCTT GAAUAGAAGAGUUCCUCUATT 13429.2S1343CUCUUCUAUUCUUAUGCUATT UAGCAUAAGAAUAGAAGAGTT 13414.1S1344AUUCACUGAUGGUGUUUGUTT ACAAACACCAUCAGUGAAUTT 13429.2S1345UUCACUGAUGGUGUUUGUUTT AACAAACACCAUCAGUGAATT 13429.2S1346UUGUAACGUUGAUCGUUACTT GUAACGAUCAACGUUACAATT 13429.2S1347CGUUGAUCGUUACCCAGCCTT GGCUGGGUAACGAUCAACGTT 13489.6S1348UGCAAUUGUGUGUAGGUUUTT AAACCUACACACAAUUGCATT 13429.2S1349UUGUGUGUAGGUUUGACACTT GUGUCAAACCUACACACAATT 13444.3S1350GAGUCUUGUCAAACUUGAATT UUCAAGUUUGACAAGACUCTT 13429.2S1351ACUUGAACUUACCAGGCUGTT CAGCCUGGUAAGUUCAAGUTT 13459.4S1352CUUGAACUUACCAGGCUGUTT ACAGCCUGGUAAGUUCAAGTT 13459.4S1353CUUACCAGGCUGUGAUGGUTT ACCAUCACAGCCUGGUAAGTT 13474.5S1354UAAGCAUGCAUUCCACACUTT AGUGUGGAAUGCAUGCUUATT 13444.3S1355GCAUGCAUUCCACACUCCATT UGGAGUGUGGAAUGCAUGCTT 13474.5S1356UUUAAAGCAAUUGCCUUUCTT GAAAGGCAAUUGCUUUAAATT 13414.1S1357AGCAAUUGCCUUUCUUUUATT UAAAAGAAAGGCAAUUGCUTT 13414.1S1358GCAAUUGCCUUUCUUUUACTT GUAAAAGAAAGGCAAUUGCTT 13429.2S1359ACAAGUAGUGUCGGAUAUUTT AAUAUCCGACACUACUUGUTT 13429.2S1360CAAGUAGUGUCGGAUAUUGTT CAAUAUCCGACACUACUUGTT 13444.3S1361GUAGUGUCGGAUAUUGAUUTT AAUCAAUAUCCGACACUACTT 13429.2S1362AUCUGCUACGUGUAUUACATT UGUAAUACACGUAGCAGAUTT 13429.2
S1363UCUGCUACGUGUAUUACACTT GUGUAAUACACGUAGCAGATT 13444.3S1364UUUAGGUGGUGCUGUUUGCTT GCAAACAGCACCACCUAAATT 13459.4S1365AUGAGUACCGACAGUACUUTT AAGUACUGUCGGUACUCAUTT 13444.3S1366UGAGUACCGACAGUACUUGTT CAAGUACUGUCGGUACUCATT 13459.4S1367UAUGAUGAUUUCUGCUGGATT UCCAGCAGAAAUCAUCAUATT 13429.2S1368CCUGUGGAAUACAUUUACCTT GGUAAAUGUAUUCCACAGGTT 13444.3S1369UACAUUUACCAGGUUACAGTT CUGUAACCUGGUAAAUGUATT 13429.2S1370AAUGUGGCUUAUAAUGUUGTT CAACAUUAUAAGCCACAUUTT 13414.1S1371AUGUGGCUUAUAAUGUUGUTT ACAACAUUAUAAGCCACAUTT 13414.1S1372UGUGGCUUAUAAUGUUGUUTT AACAACAUUAUAAGCCACATT 13414.1S1373UGUUGUUAAUAAAGGACACTT GUGUCCUUUAUUAACAACATT 13414.1S1374UAAAGGACACUUUGAUGGATT UCCAUCAAAGUGUCCUUUATT 13429.2S1375AGGACACUUUGAUGGACACTT GUGUCCAUCAAAGUGUCCUTT 13459.4S1376GGACACUUUGAUGGACACGTT CGUGUCCAUCAAAGUGUCCTT 13474.5S1377GCACCUGUUUCCAUCAUUATT UAAUGAUGGAAACAGGUGCTT 13444.3S1378UAAUGCUGUUUACACAAAGTT CUUUGUGUAAACAGCAUUATT 13414.1S1379UGCUGUUUACACAAAGGUATT UACCUUUGUGUAAACAGCATT 13429.2S1380AGGUAGAUGGUAUUGAUGUTT ACAUCAAUACCAUCUACCUTT 13429.2S1381GGUAGAUGGUAUUGAUGUGTT CACAUCAAUACCAUCUACCTT 13444.3S1382AAUAAGACAACACUUCCUGTT CAGGAAGUGUUGUCUUAUUTT 13429.2S1383AUAAGACAACACUUCCUGUTT ACAGGAAGUGUUGUCUUAUTT 13429.2S1384UAAGACAACACUUCCUGUUTT AACAGGAAGUGUUGUCUUATT 13429.2S1385GACAACACUUCCUGUUAAUTT AUUAACAGGAAGUGUUGUCTT 13429.2S1386CACUUCCUGUUAAUGUUGCTT GCAACAUUAACAGGAAGUGTT 13444.3S1387UGUUGCAUUUGAGCUUUGGTT CCAAAGCUCAAAUGCAACATT 13444.3S1388GCGUAACAUUAAACCAGUGTT CACUGGUUUAAUGUUACGCTT 13444.3S1389CAUUAAACCAGUGCCAGAGTT CUCUGGCACUGGUUUAAUGTT 13459.4S1390ACCAGUGCCAGAGAUUAAGTT CUUAAUCUCUGGCACUGGUTT 13459.4S1391CCAGUGCCAGAGAUUAAGATT UCUUAAUCUCUGGCACUGGTT 13459.4S1392GAUACUCAAUAAUUUGGGUTT ACCCAAAUUAUUGAGUAUCTT 13414.1S1393UAAUUUGGGUGUUGAUAUCTT GAUAUCAACACCCAAAUUATT 13414.1S1394UUUGGGUGUUGAUAUCGCUTT AGCGAUAUCAACACCCAAATT 13444.3S1395UACUGUAAUCUGGGACUACTT GUAGUCCCAGAUUACAGUATT 13444.3S1396UCUGGGACUACAAAAGAGATT UCUCUUUUGUAGUCCCAGATT 13444.3
S1397 AAGAGAAGCCCCAGCACAUTTAUGUGCUGGGGCUUCUCUUTT 13474.5S1398 AGAGAAGCCCCAGCACAUGTTCAUGUGCUGGGGCUUCUCUTT 13489.6S1399 GAGAAGCCCCAGCACAUGUTTACAUGUGCUGGGGCUUCUCTT 13489.6S1400 GCCCCAGCACAUGUAUCUATTUAGAUACAUGUGCUGGGGCTT 13474.5S1401 UAGGUGUCUGCACAAUGACTTGUCAUUGUGCAGACACCUATT 13459.4S1402 UGACUGACAUUGCCAAGAATTUUCUUGGCAAUGUCAGUCATT 13444.3S1403 GAAACCUACUGAGAGUGCUTTAGCACUCUCAGUAGGUUUCTT 13459.4S1404 ACCUACUGAGAGUGCUUGUTTACAAGCACUCUCAGUAGGUTT 13459.4S1405 CCUACUGAGAGUGCUUGUUTTAACAAGCACUCUCAGUAGGTT 13459.4S1406 GGACAGGUAGACCUUUUUATTUAAAAAGGUCUACCUGUCCTT 13444.3S1407 ACGCCCGUAAUGGUGUUUUTTAAAACACCAUUACGGGCGUTT 13459.4S1408 CGCCCGUAAUGGUGUUUUATTUAAAACACCAUUACGGGCGTT 13459.4S1409 UAACAGAAGGUUCAGUCAATTUUGACUGAACCUUCUGUUATT 13429.2S1410 CAGAAGGUUCAGUCAAAGGTTCCUUUGACUGAACCUUCUGTT 13459.4S1411 GGUUCAGUCAAAGGUCUAATTUUAGACCUUUGACUGAACCTT 13444.3S1412 AGGUCUAACACCUUCAAAGTTCUUUGAAGGUGUUAGACCUTT 13444.3S1413 GGUCUAACACCUUCAAAGGTTCCUUUGAAGGUGUUAGACCTT 13459.4S1414 AGGGACCAGCACAAGCUAGTTCUAGCUUGUGCUGGUCCCUTT 13489.6S1415 GGGACCAGCACAAGCUAGCTTGCUAGCUUGUGCUGGUCCCTT 13504.7S1416 GCUAGCGUCAAUGGAGUCATTUGACUCCAUUGACGCUAGCTT 13474.5S1417 UGGAGUCACAUUAAUUGGATTUCCAAUUAAUGUGACUCCATT 13429.2S1418 UUGGAGAAUCAGUAAAAACTTGUUUUUACUGAUUCUCCAATT 13414.1S1419 CUACUUUAAGAAAGUAGACTTGUCUACUUUCUUAAAGUAGTT 13414.1S1420 GAAAGUAGACGGCAUUAUUTTAAUAAUGCCGUCUACUUUCTT 13429.2S1421 AGUAGACGGCAUUAUUCAATTUUGAAUAAUGCCGUCUACUTT 13429.2S1422 GUAGACGGCAUUAUUCAACTTGUUGAAUAAUGCCGUCUACTT 13444.3S1423 CAGUUGCCUGAAACCUACUTTAGUAGGUUUCAGGCAACUGTT 13459.4S1424 ACCUACUUUACUCAGAGCATTUGCUCUGAGUAAAGUAGGUTT 13444.3S1425 CCUACUUUACUCAGAGCAGTTCUGCUCUGAGUAAAGUAGGTT 13459.4S1426 GCCCAGAUCACAAAUGGAATTUUCCAUUUGUGAUCUGGGCTT 13459.4S1427 AUGGAAACUGACUUUCUCGTTCGAGAAAGUCAGUUUCCAUTT 13444.3S1428 UGGAAACUGACUUUCUCGATTUCGAGAAAGUCAGUUUCCATT 13444.3S1429 ACUGACUUUCUCGAGCUCGTTCGAGCUCGAGAAAGUCAGUTT 13474.5S1430 CUGACUUUCUCGAGCUCGCTTGCGAGCUCGAGAAAGUCAGTT 13489.6
S1431 UUCAUACAGCGAUAUAAGCTT GCUUAUAUCGCUGUAUGAATT 13429.2S1432 GCUCGAGGGCUAUGCCUUCTT GAAGGCAUAGCCCUCGAGCTT 13504.7S1433 CACAUCGUUUAUGGAGAUUTT AAUCUCCAUAAACGAUGUGTT 13429.2S1434 CUUGGCGGUCUUCAUUUAATT UUAAAUGAAGACCGCCAAGTT 13444.3S1435 UGAUAGGCUUAGCCAAGCGTT CGCUUGGCUAAGCCUAUCATT 13474.5S1436 GCGCUCACAAGAUUCACCATT UGGUGAAUCUUGUGAGCGCTT 13474.5S1437 GAUUCACCACUUAAAUUAGTT CUAAUUUAAGUGGUGAAUCTT 13414.1S1438 AUUAGAGGAUUUUAUCCCUTT AGGGAUAAAAUCCUCUAAUTT 13414.1S1439 UUAGAGGAUUUUAUCCCUATT UAGGGAUAAAAUCCUCUAATT 13414.1S1440 AUUACUUCAUAACAGAUGCTT GCAUCUGUUAUGAAGUAAUTT 13414.1S1441 UUACUUCAUAACAGAUGCGTT CGCAUCUGUUAUGAAGUAATT 13429.2S1442 CAGAUGCGCAAACAGGUUCTT GAACCUGUUUGCGCAUCUGTT 13474.5S1443 ACAGGUUCAUCAAAAUGUGTT CACAUUUUGAUGAACCUGUTT 13429.2S1444 CAGGUUCAUCAAAAUGUGUTT ACACAUUUUGAUGAACCUGTT 13429.2S1445 AAUGUGUGUGUUCUGUGAUTT AUCACAGAACACACACAUUTT 13429.2S1446 AUGUGUGUGUUCUGUGAUUTT AAUCACAGAACACACACAUTT 13429.2S1447 UGUGUGUGUUCUGUGAUUGTT CAAUCACAGAACACACACATT 13444.3S1448 UAAAGUCACAAGAUUUGUCTT GACAAAUCUUGUGACUUUATT 13414.1S1449 AGUCACAAGAUUUGUCAGUTT ACUGACAAAUCUUGUGACUTT 13429.2S1450 GUCACAAGAUUUGUCAGUGTT CACUGACAAAUCUUGUGACTT 13444.3S1451 GAUUUGUCAGUGAUUUCAATT UUGAAAUCACUGACAAAUCTT 13414.1S1452 AAGUGGUCAAGGUUACAAUTT AUUGUAACCUUGACCACUUTT 13429.2S1453 AGUGGUCAAGGUUACAAUUTT AAUUGUAACCUUGACCACUTT 13429.2S1454 GUGGUCAAGGUUACAAUUGTT CAAUUGUAACCUUGACCACTT 13444.3S1455 GGUUACAAUUGACUAUGCUTT AGCAUAGUCAAUUGUAACCTT 13429.2S1456 UUGACUAUGCUGAAAUUUCTT GAAAUUUCAGCAUAGUCAATT 13414.1S1457 AUUUCAUUCAUGCUUUGGUTT ACCAAAGCAUGAAUGAAAUTT 13414.1S1458 UUUCAUUCAUGCUUUGGUGTT CACCAAAGCAUGAAUGAAATT 13429.2S1459 GGAUGGACAUGUUGAAACCTT GGUUUCAACAUGUCCAUCCTT 13459.4S1460 ACCUUCUACCCAAAACUACTT GUAGUUUUGGGUAGAAGGUTT 13444.3S1461 CCUUCUACCCAAAACUACATT UGUAGUUUUGGGUAGAAGGTT 13444.3S1462 AACUACAAGCAAGUCGAGCTT GCUCGACUUGCUUGUAGUUTT 13459.4S1463 ACUACAAGCAAGUCGAGCGTT CGCUCGACUUGCUUGUAGUTT 13474.5S1464 CUACAAGCAAGUCGAGCGUTT ACGCUCGACUUGCUUGUAGTT 13474.5
S1465GCAAGUCGAGCGUGGCAACTTGUUGCCACGCUCGACUUGCTT 13504.7S1466GUCGAGCGUGGCAACCAGGTTCCUGGUUGCCACGCUCGACTT 13519.8S1467CCAGGUGUUGCGAUGCCUATTUAGGCAUCGCAACACCUGGTT 13489.6S1468CUUGUACAAGAUGCAAAGATTUCUUUGCAUCUUGUACAAGTT 13429.2S1469GAUGCAAAGAAUGCUUCUUTTAAGAAGCAUUCUUUGCAUCTT 13429.2S1470AGAAUGCUUCUUGAAAAGUTTACUUUUCAAGAAGCAUUCUTT 13414.1S1471GAAUGCUUCUUGAAAAGUGTTCACUUUUCAAGAAGCAUUCTT 13429.2S1472UGCUUCUUGAAAAGUGUGATTUCACACUUUUCAAGAAGCATT 13429.2S1473AAGUGUGACCUUCAGAAUUTTAAUUCUGAAGGUCACACUUTT 13429.2S1474AGUGUGACCUUCAGAAUUATTUAAUUCUGAAGGUCACACUTT 13429.2S1475GUGUGACCUUCAGAAUUAUTTAUAAUUCUGAAGGUCACACTT 13429.2S1476UUAUGGUGAAAAUGCUGUUTTAACAGCAUUUUCACCAUAATT 13414.1S1477AAUGCUGUUAUACCAAAAGTTCUUUUGGUAUAACAGCAUUTT 13414.1S1478AUGCUGUUAUACCAAAAGGTTCCUUUUGGUAUAACAGCAUTT 13429.2S1479UGCUGUUAUACCAAAAGGATTUCCUUUUGGUAUAACAGCATT 13429.2S1480AGGAAUAAUGAUGAAUGUCTTGACAUUCAUCAUUAUUCCUTT 13414.1S1481GGAAUAAUGAUGAAUGUCGTTCGACAUUCAUCAUUAUUCCTT 13429.2S1482UAAUGAUGAAUGUCGCAAATTUUUGCGACAUUCAUCAUUATT 13414.1S1483UGAUGAAUGUCGCAAAGUATTUACUUUGCGACAUUCAUCATT 13429.2S1484UGUCGCAAAGUAUACUCAATTUUGAGUAUACUUUGCGACATT 13429.2S1485AGUAUACUCAACUGUGUCATTUGACACAGUUGAGUAUACUTT 13429.2S1486GUAUACUCAACUGUGUCAATTUUGACACAGUUGAGUAUACTT 13429.2S1487AUACACUUACUUUAGCUGUTTACAGCUAAAGUAAGUGUAUTT 13414.1S1488UACACUUACUUUAGCUGUATTUACAGCUAAAGUAAGUGUATT 13414.1S1489CAUGAGAGUUAUUCACUUUTTAAAGUGAAUAACUCUCAUGTT 13414.1S1490AGGAGUUGCACCAGGUACATTUGUACCUGGUGCAACUCCUTT 13474.5S1491GGAGUUGCACCAGGUACAGTTCUGUACCUGGUGCAACUCCTT 13489.6S1492UGGUUGCCAACUGGCACACTTGUGUGCCAGUUGGCAACCATT 13489.6S1493CUGGCACACUACUUGUCGATTUCGACAAGUAGUGUGCCAGTT 13474.5S1494UGACUUCGUCUCCGACGCATTUGCGUCGGAGACGAAGUCATT 13489.6S1495UUGGAGACUGUGCAACAGUTTACUGUUGCACAGUCUCCAATT 13459.4S1496CAGUACAUACGGCUAAUAATTUUAUUAGCCGUAUGUACUGTT 13429.2S1497AUGGGACCUUAUUAUUAGCTTGCUAAUAAUAAGGUCCCAUTT 13429.2S1498UGGGACCUUAUUAUUAGCGTTCGCUAAUAAUAAGGUCCCATT 13444.3
S1499 ACAUGUGACAAAAGAGAAUTT AUUCUCUUUUGUCACAUGUTT 13414.1S1500 CAUGUGACAAAAGAGAAUGTT CAUUCUCUUUUGUCACAUGTT 13429.2S1501 AAGAGAAUGACUCUAAAGATT UCUUUAGAGUCAUUCUCUUTT 13414.1S1502 AGAGAAUGACUCUAAAGAATT UUCUUUAGAGUCAUUCUCUTT 13414.1S1503 GAGAAUGACUCUAAAGAAGTT CUUCUUUAGAGUCAUUCUCTT 13429.2S1504 UGACUCUAAAGAAGGGUUUTT AAACCCUUCUUUAGAGUCATT 13429.2S1505 AGAAGGGUUUUUCACUUAUTT AUAAGUGAAAAACCCUUCUTT 13414.1S1506 GAAGGGUUUUUCACUUAUCTT GAUAAGUGAAAAACCCUUCTT 13429.2S1507 GGGUUUUUCACUUAUCUGUTT ACAGAUAAGUGAAAAACCCTT 13429.2S1508 AGCAAAAACUAGCCCUGGGTT CCCAGGGCUAGUUUUUGCUTT 13474.5S1509 GCAAAAACUAGCCCUGGGUTT ACCCAGGGCUAGUUUUUGCTT 13474.5S1510 AAACUAGCCCUGGGUGGUUTT AACCACCCAGGGCUAGUUUTT 13474.5S1511 AACUAGCCCUGGGUGGUUCTT GAACCACCCAGGGCUAGUUTT 13489.6S1512 ACUAGCCCUGGGUGGUUCUTT AGAACCACCCAGGGCUAGUTT 13489.6S1513 CUAGCCCUGGGUGGUUCUATT UAGAACCACCCAGGGCUAGTT 13489.6S1514 AGAUAACAGAGCAUUCUUGTT CAAGAAUGCUCUGUUAUCUTT 13429.2S1515 GAUAACAGAGCAUUCUUGGTT CCAAGAAUGCUCUGUUAUCTT 13444.3S1516 CAGAGCAUUCUUGGAAUGCTT GCAUUCCAAGAAUGCUCUGTT 13459.4S1517 UGCUGACCUUUACAAGCUUTT AAGCUUGUAAAGGUCAGCATT 13444.3S1518 GCUUAUGGGCCAUUUCUCATT UGAGAAAUGGCCCAUAAGCTT 13459.4S1519 AUGUAAAUGCAUCAUCAUCTT GAUGAUGAUGCAUUUACAUTT 13414.1S1520 UGUAAAUGCAUCAUCAUCGTT CGAUGAUGAUGCAUUUACATT 13429.2S1521 AUGCAUCAUCAUCGGAAGCTT GCUUCCGAUGAUGAUGCAUTT 13459.4S1522 UGCAUCAUCAUCGGAAGCATT UGCUUCCGAUGAUGAUGCATT 13459.4S1523 GCAUUUUUAAUUGGGGCUATT UAGCCCCAAUUAAAAAUGCTT 13429.2S1524 UUGGGGCUAACUAUCUUGGTT CCAAGAUAGUUAGCCCCAATT 13459.4S1525 CUAUCUUGGCAAGCCGAAGTT CUUCGGCUUGCCAAGAUAGTT 13474.5S1526 GCCGAAGGAACAAAUUGAUTT AUCAAUUUGUUCCUUCGGCTT 13444.3S1527 GGAACAAAUUGAUGGCUAUTT AUAGCCAUCAAUUUGUUCCTT 13429.2S1528 CAAAUUGAUGGCUAUACCATT UGGUAUAGCCAUCAAUUUGTT 13429.2S1529 AUUGAUGGCUAUACCAUGCTT GCAUGGUAUAGCCAUCAAUTT 13444.3S1530 UUGAUGGCUAUACCAUGCATT UGCAUGGUAUAGCCAUCAATT 13444.3S1531 CUACAUUUUCUGGAGGAACTT GUUCCUCCAGAAAAUGUAGTT 13444.3S1532 CACAAAUCCUAUCCAGUUGTT CAACUGGAUAGGAUUUGUGTT 13444.3
S1533 AUCCUAUCCAGUUGUCUUCTT GAAGACAACUGGAUAGGAUTT 13444.3S1534 UCCUAUCCAGUUGUCUUCCTT GGAAGACAACUGGAUAGGATT 13459.4S1535 AUUAAGAGGAACUGCUGUATT UACAGCAGUUCCUCUUAAUTT 13429.2S1536 UUAAGAGGAACUGCUGUAATT UUACAGCAGUUCCUCUUAATT 13429.2S1537 GAGGAACUGCUGUAAUGUCTT GACAUUACAGCAGUUCCUCTT 13459.4S1538 CUGCUGUAAUGUCUCUUAATT UUAAGAGACAUUACAGCAGTT 13429.2S1539 UGUCUCUUAAGGAGAAUCATT UGAUUCUCCUUAAGAGACATT 13429.2S1540 GGAGAAUCAAAUCAAUGAUTT AUCAUUGAUUUGAUUCUCCTT 13414.1S1541 AAAGGUAGGCUUAUCAUUATT UAAUGAUAAGCCUACCUUUTT 13414.1S1542 AAGGUAGGCUUAUCAUUAGTT CUAAUGAUAAGCCUACCUUTT 13429.2S1543 AGGUAGGCUUAUCAUUAGATT UCUAAUGAUAAGCCUACCUTT 13429.2S1544 GGUAGGCUUAUCAUUAGAGTT CUCUAAUGAUAAGCCUACCTT 13444.3S1545 AACAACAGAGUUGUGGUUUTT AAACCACAACUCUGUUGUUTT 13429.2S1546 ACAACAGAGUUGUGGUUUCTT GAAACCACAACUCUGUUGUTT 13444.3S1547 CAACAGAGUUGUGGUUUCATT UGAAACCACAACUCUGUUGTT 13444.3S1548 CAGAGUUGUGGUUUCAAGUTT ACUUGAAACCACAACUCUGTT 13444.3上表中S1-S995SiRNA的目标基因是多功能聚合酶a和多功能聚合酶b，S996-S1548SiRNA的目标基因是多功能聚合酶b。
表4、针对第二编码区的SiRNA分子序号正义链序列 反义链序列MWS1549 UUACACUCAACAUACUUCATT UGAAGUAUGUUGAGUGUAATT13414.1S1550 CAUACUUCAUCUAUGAGGGTT CCCUCAUAGAUGAAGUAUGTT13444.3S1551 AUUUUUAGAUCAGACACUCTT GAGUGUCUGAUCUAAAAAUTT13414.1S1552 UUUUUAGAUCAGACACUCUTT AGAGUGUCUGAUCUAAAAATT13414.1S1553 UGUUACAGGGUUUCAUACUTT AGUAUGAAACCCUGUAACATT13429.2S1554 UCAUACGUUUGGCAACCCUTT AGGGUUGCCAAACGUAUGATT13459.4S1555 CCCUGUCAUACCUUUUAAGTT CUUAAAAGGUAUGACAGGGTT13444.3S1556 GGAUGGUAUUUAUUUUGCUTT AGCAAAAUAAAUACCAUCCTT13414.1S1557 AUCAAAUGUUGUCCGUGGUTT ACCACGGACAACAUUUGAUTT13444.3S1558 AUGUUGUCCGUGGUUGGGUTT ACCCAACCACGGACAACAUTT13474.5S1559 UGUUGUCCGUGGUUGGGUUTT AACCCAACCACGGACAACATT13474.5S1560 UGUUGUUAUACGAGCAUGUTT ACAUGCUCGUAUAACAACATT13429.2S1561 CUUUGAAUUGUGUGACAACTT GUUGUCACACAAUUCAAAGTT13429.2S1562 UUGUGUGACAACCCUUUCUTT AGAAAGGGUUGUCACACAATT13444.3S1563 CCCUUUCUUUGCUGUUUCUTT AGAAACAGCAAAGAAAGGGTT13444.3S1564 ACCCAUGGGUACACAGACATT UGUCUGUGUACCCAUGGGUTT13474.5S1565 CCCAUGGGUACACAGACACTT GUGUCUGUGUACCCAUGGGTT13489.6S1566 UGCAUUUAAUUGCACUUUCTT GAAAGUGCAAUUAAAUGCATT13414.1
S1567UUGCACUUUCGAGUACAUATT UAUGUACUCGAAAGUGCAATT 13429.2S1568GUCAGGUAAUUUUAAACACTT GUGUUUAAAAUUACCUGACTT 13414.1S1569UUUUAAACACUUACGAGAGTT CUCUCGUAAGUGUUUAAAATT 13414.1S1570ACACUUACGAGAGUUUGUGTT CACAAACUCUCGUAAGUGUTT 13444.3S1571AAUAAAGAUGGGUUUCUCUTT AGAGAAACCCAUCUUUAUUTT 13414.1S1572AUAAAGAUGGGUUUCUCUATT UAGAGAAACCCAUCUUUAUTT 13414.1S1573UAAAGAUGGGUUUCUCUAUTT AUAGAGAAACCCAUCUUUATT 13414.1S1574AGAUGGGUUUCUCUAUGUUTT AACAUAGAGAAACCCAUCUTT 13429.2S1575GAUGGGUUUCUCUAUGUUUTT AAACAUAGAGAAACCCAUCTT 13429.2S1576GGGCUAUCAACCUAUAGAUTT AUCUAUAGGUUGAUAGCCCTT 13444.3S1577ACCUAUUUUUAAGUUGCCUTT AGGCAACUUAAAAAUAGGUTT 13414.1S1578CCUAUUUUUAAGUUGCCUCTT GAGGCAACUUAAAAAUAGGTT 13429.2S1579CAUUACAAAUUUUAGAGCCTT GGCUCUAAAAUUUGUAAUGTT 13414.1S1580AUUUUAGAGCCAUUCUUACTT GUAAGAAUGGCUCUAAAAUTT 13414.1S1581UUUUAGAGCCAUUCUUACATT UGUAAGAAUGGCUCUAAAATT 13414.1S1582GACAUUUGGGGCACGUCAGTT CUGACGUGCCCCAAAUGUCTT 13489.6S1583AGCCAACUACAUUUAUGCUTT AGCAUAAAUGUAGUUGGCUTT 13429.2S1584CUACAUUUAUGCUCAAGUATT UACUUGAGCAUAAAUGUAGTT 13414.1S1585GUAUGAUGAAAAUGGUACATT UGUACCAUUUUCAUCAUACTT 13414.1S1586AAUGGUACAAUCACAGAUGTT CAUCUGUGAUUGUACCAUUTT 13429.2S1587AUGGUACAAUCACAGAUGCTT GCAUCUGUGAUUGUACCAUTT 13444.3S1588AAUCCACUUGCUGAACUCATT UGAGUUCAGCAAGUGGAUUTT 13444.3S1589AUCCACUUGCUGAACUCAATT UUGAGUUCAGCAAGUGGAUTT 13444.3S1590CUCAAAUGCUCUGUUAAGATT UCUUAACAGAGCAUUUGAGTT 13429.2S1591AUGCUCUGUUAAGAGCUUUTT AAAGCUCUUAACAGAGCAUTT 13429.2S1592GAGCUUUGAGAUUGACAAATT UUUGUCAAUCUCAAAGCUCTT 13429.2S1593AGGAAUUUACCAGACCUCUTT AGAGGUCUGGUAAAUUCCUTT 13444.3S1594UUUACCAGACCUCUAAUUUTT AAAUUAGAGGUCUGGUAAATT 13414.1S1595UUUCAGGGUUGUUCCCUCATT UGAGGGAACAACCCUGAAATT 13459.4S1596UAUUACAAACUUGUGUCCUTT AGGACACAAGUUUGUAAUATT 13414.1S1597ACUUGUGUCCUUUUGGAGATT UCUCCAAAAGGACACAAGUTT 13444.3S1598CUUGUGUCCUUUUGGAGAGTT CUCUCCAAAAGGACACAAGTT 13459.4S1599UGCUACUAAAUUCCCUUCUTT AGAAGGGAAUUUAGUAGCATT 13429.2S1600AUUCCCUUCUGUCUAUGCATT UGCAUAGACAGAAGGGAAUTT 13444.3S1601UUCCCUUCUGUCUAUGCAUTT AUGCAUAGACAGAAGGGAATT 13444.3S1602AUUUCUAAUUGUGUUGCUGTT CAGCAACACAAUUAGAAAUTT 13414.1S1603UUUCUAAUUGUGUUGCUGATT UCAGCAACACAAUUAGAAATT 13414.1S1604UUGUGUUGCUGAUUACUCUTT AGAGUAAUCAGCAACACAATT 13429.2S1605CUCAACAUUUUUUUCAACCTT GGUUGAAAAAAAUGUUGAGTT 13414.1S1606UGAUCUUUGCUUCUCCAAUTT AUUGGAGAAGCAAAGAUCATT 13429.2S1607UGUCUAUGCAGAUUCUUUUTT AAAAGAAUCUGCAUAGACATT 13414.1S1608GGGAGAUGAUGUAAGACAATT UUGUCUUACAUCAUCUCCCTT 13444.3
S1609 AUAGCGCCAGGACAAACUGTT CAGUUUGUCCUGGCGCUAUTT 13474.5S1610 ACUGGUGUUAUUGCUGAUUTT AAUCAGCAAUAACACCAGUTT 13429.2S1611 CUGGUGUUAUUGCUGAUUATT UAAUCAGCAAUAACACCAGTT 13429.2S1612 AUUGCCAGAUGAUUUCAUGTT CAUGAAAUCAUCUGGCAAUTT 13429.2S1613 UACUAGGAACAUUGAUGCUTT AGCAUCAAUGUUCCUAGUATT 13429.2S1614 UAUAGGUAUCUUAGACAUGTT CAUGUCUAAGAUACCUAUATT 13414.1S1615 GCUUAGGCCCUUUGAGAGATT UCUCUCAAAGGGCCUAAGCTT 13474.5S1616 UGUGCCUUUCUCCCCUGAUTT AUCAGGGGAGAAAGGCACATT 13474.5S1617 ACCUUGCACCCCACCUGCUTT AGCAGGUGGGGUGCAAGGUTT 13504.7S1618 CCUUGCACCCCACCUGCUCTT GAGCAGGUGGGGUGCAAGGTT 13519.8S1619 UGAUUAUGGUUUUUACACCTT GGUGUAAAAACCAUAAUCATT 13414.1S1620 CUUUUAAAUGCACCGGCCATT UGGCCGGUGCAUUUAAAAGTT 13459.4S1621 AUGCACCGGCCACGGUUUGTT CAAACCGUGGCCGGUGCAUTT 13504.7S1622 UGCACCGGCCACGGUUUGUTT ACAAACCGUGGCCGGUGCATT 13504.7S1623 AAUUAUCCACUGACCUUAUTT AUAAGGUCAGUGGAUAAUUTT 13414.1S1624 AUUAUCCACUGACCUUAUUTT AAUAAGGUCAGUGGAUAAUTT 13414.1S1625 UUAUCCACUGACCUUAUUATT UAAUAAGGUCAGUGGAUAATT 13414.1S1626 GAACCAGUGUGUCAAUUUUTT AAAAUUGACACACUGGUUCTT 13429.2S1627 CCAGUGUGUCAAUUUUAAUTT AUUAAAAUUGACACACUGGTT 13414.1S1628 UUUUAAUGGACUCACUGGUTT ACCAGUGAGUCCAUUAAAATT 13429.2S1629 CUCCUUCUUCAAAGAGAUUTT AAUCUCUUUGAAGAAGGAGTT 13429.2S1630 AGAGAUUUCAACCAUUUCATT UGAAAUGGUUGAAAUCUCUTT 13414.1S1631 GAGAUUUCAACCAUUUCAATT UUGAAAUGGUUGAAAUCUCTT 13414.1S1632 UAUUAGACAUUUCACCUUGTT CAAGGUGAAAUGUCUAAUATT 13414.1S1633 CAAAUGCUUCAUCUGAAGUTT ACUUCAGAUGAAGCAUUUGTT 13429.2S1634 AUGCUUCAUCUGAAGUUGCTT GCAACUUCAGAUGAAGCAUTT 13444.3S1635 GUUGCUGUUCUAUAUCAAGTT CUUGAUAUAGAACAGCAACTT 13429.2S1636 CUCACACCAGCUUGGCGCATT UGCGCCAAGCUGGUGUGAGTT 13504.7S1637 ACAAUGUAUUCCAGACUCATT UGAGUCUGGAAUACAUUGUTT 13429.2S1638 CAAUGUAUUCCAGACUCAATT UUGAGUCUGGAAUACAUUGTT 13429.2S1639 AAUCUAUUGUGGCUUAUACTT GUAUAAGCCACAAUAGAUUTT 13414.1S1640 AUCUAUUGUGGCUUAUACUTT AGUAUAAGCCACAAUAGAUTT 13414.1S1641 UCUAUUGUGGCUUAUACUATT UAGUAUAAGCCACAAUAGATT 13414.1S1642 UUGCUUACUCUAAUAACACTT GUGUUAUUAGAGUAAGCAATT 13414.1S1643 UAACACCAUUGCUAUACCUTT AGGUAUAGCAAUGGUGUUATT 13429.2S1644 UUAGCAUUACUACAGAAGUTT ACUUCUGUAGUAAUGCUAATT 13414.1S1645 AACCUCCGUAGAUUGUAAUTT AUUACAAUCUACGGAGGUUTT 13429.2S1646 ACCUCCGUAGAUUGUAAUATT UAUUACAAUCUACGGAGGUTT 13429.2S1647 CCUCCGUAGAUUGUAAUAUTT AUAUUACAAUCUACGGAGGTT 13429.2S1648 UUUGCUUCUCCAAUAUGGUTT ACCAUAUUGGAGAAGCAAATT 13429.2S1649 UAUGGUAGCUUUUGCACACTT GUGUGCAAAAGCUACCAUATT 13444.3S1650 AUCGUGCACUCUCAGGUAUTT AUACCUGAGAGUGCACGAUTT 13459.4
S1651ACAAAUGUACAAAACCCCATT UGGGGUUUUGUACAUUUGUTT 13429.2S1652CAAAUGUACAAAACCCCAATT UUGGGGUUUUGUACAUUUGTT 13429.2S1653AUGUACAAAACCCCAACUUTT AAGUUGGGGUUUUGUACAUTT 13429.2S1654UGUACAAAACCCCAACUUUTT AAAGUUGGGGUUUUGUACATT 13429.2S1655AACCCCAACUUUGAAAUAUTT AUAUUUCAAAGUUGGGGUUTT 13414.1S1656ACCCCAACUUUGAAAUAUUTT AAUAUUUCAAAGUUGGGGUTT 13414.1S1657CCCCAACUUUGAAAUAUUUTT AAAUAUUUCAAAGUUGGGGTT 13414.1S1658CUUUGAAAUAUUUUGGUGGTT CCACCAAAAUAUUUCAAAGTT 13414.1S1659AUAUUACCUGACCCUCUAATT UUAGAGGGUCAGGUAAUAUTT 13429.2S1660UAUUACCUGACCCUCUAAATT UUUAGAGGGUCAGGUAAUATT 13429.2S1661AGCCAACUAAGAGGUCUUUTT AAAGACCUCUUAGUUGGCUTT 13444.3S1662GCCAACUAAGAGGUCUUUUTT AAAAGACCUCUUAGUUGGCTT 13444.3S1663CUAAGAGGUCUUUUAUUGATT UCAAUAAAAGACCUCUUAGTT 13414.1S1664GAGGUCUUUUAUUGAGGACTT GUCCUCAAUAAAAGACCUCTT 13444.3S1665UGCCUAGGUGAUAUUAAUGTT CAUUAAUAUCACCUAGGCATT 13429.2S1666UGCUAGAGAUCUCAUUUGUTT ACAAAUGAGAUCUCUAGCATT 13429.2S1667AUACCUUUUGCUAUGCAAATT UUUGCAUAGCAAAAGGUAUTT 13414.1S1668UACCUUUUGCUAUGCAAAUTT AUUUGCAUAGCAAAAGGUATT 13414.1S1669AUGGCAUAUAGGUUCAAUGTT CAUUGAACCUAUAUGCCAUTT 13429.2S1670UGGCAUUGGAGUUACCCAATT UUGGGUAACUCCAAUGCCATT 13459.4S1671AAUGUUCUCUAUGAGAACCTT GGUUCUCAUAGAGAACAUUTT 13429.2S1672AUGUUCUCUAUGAGAACCATT UGGUUCUCAUAGAGAACAUTT 13429.2S1673UGUUCUCUAUGAGAACCAATT UUGGUUCUCAUAGAGAACATT 13429.2S1674CCAAAAACAAAUCGCCAACTT GUUGGCGAUUUGUUUUUGGTT 13444.3S1675AAACAAAUCGCCAACCAAUTT AUUGGUUGGCGAUUUGUUUTT 13429.2S1676AACAAAUCGCCAACCAAUUTT AAUUGGUUGGCGAUUUGUUTT 13429.2S1677ACAAAUCGCCAACCAAUUUTT AAAUUGGUUGGCGAUUUGUTT 13429.2S1678CAAAUCGCCAACCAAUUUATT UAAAUUGGUUGGCGAUUUGTT 13429.2S1679AUCGCCAACCAAUUUAACATT UGUUAAAUUGGUUGGCGAUTT 13429.2S1680UCGCCAACCAAUUUAACAATT UUGUUAAAUUGGUUGGCGATT 13429.2S1681CCAAUUUAACAAGGCGAUUTT AAUCGCCUUGUUAAAUUGGTT 13429.2S1682UUUAACAAGGCGAUUAGUCTT GACUAAUCGCCUUGUUAAATT 13429.2S1683CAAGGCGAUUAGUCAAAUUTT AAUUUGACUAAUCGCCUUGTT 13429.2S1684GGCGAUUAGUCAAAUUCAATT UUGAAUUUGACUAAUCGCCTT 13429.2S1685UUCAAGAAUCACUUACAACTT GUUGUAAGUGAUUCUUGAATT 13414.1S1686GAAUCACUUACAACAACAUTT AUGUUGUUGUAAGUGAUUCTT 13414.1S1687UCACUUACAACAACAUCAATT UUGAUGUUGUUGUAAGUGATT 13414.1S1688CAACAUCAACUGCAUUGGGTT CCCAAUGCAGUUGAUGUUGTT 13459.4S1689CAUCAACUGCAUUGGGCAATT UUGCCCAAUGCAGUUGAUGTT 13459.4S1690CUGCAUUGGGCAAGCUGCATT UGCAGCUUGCCCAAUGCAGTT 13489.6S1691UGCUCAAGCAUUAAACACATT UGUGUUUAAUGCUUGAGCATT 13429.2S1692GCAUUAAACACACUUGUUATT UAACAAGUGUGUUUAAUGCTT 13414.1
S1693ACACACUUGUUAAACAACUTT AGUUGUUUAACAAGUGUGUTT 13414.1S1694CACACUUGUUAAACAACUUTT AAGUUGUUUAACAAGUGUGTT 13414.1S1695CAACUUAGCUCUAAUUUUGTT CAAAAUUAGAGCUAAGUUGTT 13414.1S1696CUUAGCUCUAAUUUUGGUGTT CACCAAAAUUAGAGCUAAGTT 13429.2S1697UUUUGGUGCAAUUUCAAGUTT ACUUGAAAUUGCACCAAAATT 13414.1S1698UUUCAAGUGUGCUAAAUGATT UCAUUUAGCACACUUGAAATT 13414.1S1699GUGUGCUAAAUGAUAUCCUTT AGGAUAUCAUUUAGCACACTT 13429.2S1700AUGAUAUCCUUUCGCGACUTT AGUCGCGAAAGGAUAUCAUTT 13444.3S1701AGUCGAGGCGGAGGUACAATT UUGUACCUCCGCCUCGACUTT 13489.6S1702AUUGACAGGUUAAUUACAGTT CUGUAAUUAACCUGUCAAUTT 13414.1S1703UUGACAGGUUAAUUACAGGTT CCUGUAAUUAACCUGUCAATT 13429.2S1704AGCCUUCAAACCUAUGUAATT UUACAUAGGUUUGAAGGCUTT 13429.2S1705ACCUAUGUAACACAACAACTT GUUGUUGUGUUACAUAGGUTT 13429.2S1706CCUAUGUAACACAACAACUTT AGUUGUUGUGUUACAUAGGTT 13429.2S1707CACAACAACUAAUCAGGGCTT GCCCUGAUUAGUUGUUGUGTT 13459.4S1708CAACUAAUCAGGGCUGCUGTT CAGCAGCCCUGAUUAGUUGTT 13474.5S1709CUAAUCAGGGCUGCUGAAATT UUUCAGCAGCCCUGAUUAGTT 13459.4S1710UCAGGGCUGCUGAAAUCAGTT CUGAUUUCAGCAGCCCUGATT 13474.5S1711AUCAGGGCUUCUGCUAAUCTT GAUUAGCAGAAGCCCUGAUTT 13459.4S1712UCAGGGCUUCUGCUAAUCUTT AGAUUAGCAGAAGCCCUGATT 13459.4S1713UCUUGCUGCUACUAAAAUGTT CAUUUUAGUAGCAGCAAGATT 13429.2S1714AAAGAGUUGACUUUUGUGGTT CCACAAAAGUCAACUCUUUTT 13429.2S1715AAGAGUUGACUUUUGUGGATT UCCACAAAAGUCAACUCUUTT 13429.2S1716AGAGUUGACUUUUGUGGAATT UUCCACAAAAGUCAACUCUTT 13429.2S1717GAGUUGACUUUUGUGGAAATT UUUCCACAAAAGUCAACUCTT 13429.2S1718AGGGCUACCACCUUAUGUCTT GACAUAAGGUGGUAGCCCUTT 13474.5S1719GGGCUACCACCUUAUGUCCTT GGACAUAAGGUGGUAGCCCTT 13489.6S1720GCAGCCCCGCAUGGUGUUGTT CAACACCAUGCGGGGCUGCTT 13519.8S1721CUUCACCACAGCGCCAGCATT UGCUGGCGCUGUGGUGAAGTT 13504.7S1722GGCAAAGCAUACUUCCCUCTT GAGGGAAGUAUGCUUUGCCTT 13474.5S1723AGCAUACUUCCCUCGUGAATT UUCACGAGGGAAGUAUGCUTT 13459.4S1724GCAUACUUCCCUCGUGAAGTT CUUCACGAGGGAAGUAUGCTT 13474.5S1725GGUGUUUUUGUGUUUAAUGTT CAUUAAACACAAAAACACCTT 13414.1S1726UGGCACUUCUUGGUUUAUUTT AAUAAACCAAGAAGUGCCATT 13429.2S1727CUUCUUUUCUCCACAAAUATT UAUUUGUGGAGAAAAGAAGTT 13414.1S1728UACAUUUGUCUCAGGAAAUTT AUUUCCUGAGACAAAUGUATT 13414.1S1729AUUGUGAUGUCGUUAUUGGTT CCAAUAACGACAUCACAAUTT 13429.2S1730CAACACAGUUUAUGAUCCUTT AGGAUCAUAAACUGUGUUGTT 13429.2S1731AGAAGAGCUGGACAAGUACTT GUACUUGUCCAGCUCUUCUTT 13459.4S1732AAAUCAUACAUCACCAGAUTT AUCUGGUGAUGUAUGAUUUTT 13414.1S1733AAUCAUACAUCACCAGAUGTT CAUCUGGUGAUGUAUGAUUTT 13429.2S1734AUCAUACAUCACCAGAUGUTT ACAUCUGGUGAUGUAUGAUTT 13429.2
S1735 UCAUACAUCACCAGAUGUUTT AACAUCUGGUGAUGUAUGATT 13429.2S1736 AAAGAAAUUGACCGCCUCATT UGAGGCGGUCAAUUUCUUUTT 13444.3S1737 AAGAAAUUGACCGCCUCAATT UUGAGGCGGUCAAUUUCUUTT 13444.3S1738 AUUGACCGCCUCAAUGAGGTT CCUCAUUGAGGCGGUCAAUTT 13474.5S1739 UGAGGUCGCUAAAAAUUUATT UAAAUUUUUAGCGACCUCATT 13414.1S1740 AUGAAUCACUCAUUGACCUTT AGGUCAAUGAGUGAUUCAUTT 13429.2S1741 UGAAUCACUCAUUGACCUUTT AAGGUCAAUGAGUGAUUCATT 13429.2S1742 GAAUUGGGAAAAUAUGAGCTT GCUCAUAUUUUCCCAAUUCTT 13429.2S1743 UUGGGAAAAUAUGAGCAAUTT AUUGCUCAUAUUUUCCCAATT 13414.1S1744 UAUAUUAAAUGGCCUUGGUTT ACCAAGGCCAUUUAAUAUATT 13414.1S1745 AUGGCCUUGGUAUGUUUGGTT CCAAACAUACCAAGGCCAUTT 13459.4S1746 GGGUGCAUGCUCUUGUGGUTT ACCACAAGAGCAUGCACCCTT 13489.6S1747 GGGUGUCAAAUUACAUUACTT GUAAUGUAAUUUGACACCCTT 13429.2上表中的SiRNA的目标基因为刺蛋白。
表5、针对第三编码区的SiRNA分子SiRNA序号 正义链序列 反义链序列MWS1748UUACUGCACAGCCAGUAAATT UUUACUGGCUGUGCAGUAATT 13444.3S1749AAAUUGACAAUGCUUCUCCTT GGAGAAGCAUUGUCAAUUUTT 13429.2S1750UGCUUCUCCUGCAAGUACUTT AGUACUUGCAGGAGAAGCATT 13459.4S1751GUACUGUUCAUGCUACAGCTT GCUGUAGCAUGAACAGUACTT 13459.4S1752CGAUACCGCUACAAGCCUCTT GAGGCUUGUAGCGGUAUCGTT 13489.6S1753GCCUCACUCCCUUUCGGAUTT AUCCGAAAGGGAGUGAGGCTT 13489.6S1754UAAUUGCGCUCAAUAAAAGTT CUUUUAUUGAGCGCAAUUATT 13414.1S1755UUGCGCUCAAUAAAAGAUGTT CAUCUUUUAUUGAGCGCAATT 13429.2S1756UAAAAGAUGGCAGCUAGCCTT GGCUAGCUGCCAUCUUUUATT 13459.4S1757AAGAUGGCAGCUAGCCCUUTT AAGGGCUAGCUGCCAUCUUTT 13474.5S1758AGAUGGCAGCUAGCCCUUUTT AAAGGGCUAGCUGCCAUCUTT 13474.5S1759GAUGGCAGCUAGCCCUUUATT UAAAGGGCUAGCUGCCAUCTT 13474.5S1760GGGCUUCCAGUUCAUUUGCTT GCAAAUGAACUGGAAGCCCTT 13474.5S1761UUUACUGCUGCUAUUUGUUTT AACAAAUAGCAGCAGUAAATT 13414.1S1762UUUUUGUACCUCUAUGCCUTT AGGCAUAGAGGUACAAAAATT 13429.2S1763UGCAUCAACGCAUGUAGAATT UUCUACAUGCGUUGAUGCATT 13444.3S1764CGCAUGUAGAAUUAUUAUGTT CAUAAUAAUUCUACAUGCGTT 13414.1S1765UUAUUAUGAGAUGUUGGCUTT AGCCAACAUCUCAUAAUAATT 13414.1S1766GUGCAAAUCCAAGAACCCATT UGGGUUCUUGGAUUUGCACTT 13459.4S1767AUCCAAGAACCCAUUACUUTT AAGUAAUGGGUUCUUGGAUTT 13429.2S1768UCCAAGAACCCAUUACUUUTT AAAGUAAUGGGUUCUUGGATT 13429.2S1769GAACCCAUUACUUUAUGAUTT AUCAUAAAGUAAUGGGUUCTT 13414.1S1770CCCAUUACUUUAUGAUGCCTT GGCAUCAUAAAGUAAUGGGTT 13444.3S1771CUACUUUGUUUGCUGGCACTT GUGCCAGCAAACAAAGUAGTT 13459.4S1772CUAUGACUACUGUAUACCATT UGGUAUACAGUAGUCAUAGTT 13429.2S1773CAGUGUCACAGAUACAAUUTT AAUUGUAUCUGUGACACUGTT 13429.2
S1774UUGUCGUUACUGAAGGUGATT UCACCUUCAGUAACGACAATT 13444.3S1775GGUGACGGCAUUUCAACACTT GUGUUGAAAUGCCGUCACCTT 13474.5S1776CACCAAAACUCAAAGAAGATT UCUUCUUUGAGUUUUGGUGTT 13429.2S1777AACUCAAAGAAGACUACCATT UGGUAGUCUUCUUUGAGUUTT 13429.2S1778ACUCAAAGAAGACUACCAATT UUGGUAGUCUUCUUUGAGUTT 13429.2S1779CUCAAAGAAGACUACCAAATT UUUGGUAGUCUUCUUUGAGTT 13429.2S1780AGAAGACUACCAAAUUGGUTT ACCAAUUUGGUAGUCUUCUTT 13429.2S1781GAAGACUACCAAAUUGGUGTT CACCAAUUUGGUAGUCUUCTT 13444.3S1782GACUACCAAAUUGGUGGUUTT AACCACCAAUUUGGUAGUCTT 13444.3S1783AUUGGUGGUUAUUCUGAGGTT CCUCAGAAUAACCACCAAUTT 13444.3S1784UUGGUGGUUAUUCUGAGGATT UCCUCAGAAUAACCACCAATT 13444.3S1785AGACUAUGUCGUUGUACAUTT AUGUACAACGACAUAGUCUTT 13429.2S1786GACUAUGUCGUUGUACAUGTT CAUGUACAACGACAUAGUCTT 13444.3S1787GUUUACUACCAGCUUGAGUTT ACUCAAGCUGGUAGUAAACTT 13444.3S1788AUUACUACAGACACUGGUATT UACCAGUGUCUGUAGUAAUTT 13429.2S1789UUACUACAGACACUGGUAUTT AUACCAGUGUCUGUAGUAATT 13429.2S1790AAUGCUACAUUCUUCAUCUTT AGAUGAAGAAUGUAGCAUUTT 13414.1S1791AUGCUACAUUCUUCAUCUUTT AAGAUGAAGAAUGUAGCAUTT 13414.1S1792UGCUACAUUCUUCAUCUUUTT AAAGAUGAAGAAUGUAGCATT 13414.1S1793CAAGCUUGUUAAAGACCCATT UGGGUCUUUAACAAGCUUGTT 13444.3S1794GCUUGUUAAAGACCCACCGTT CGGUGGGUCUUUAACAAGCTT 13474.5S1795AGACCCACCGAAUGUGCAATT UUGCACAUUCGGUGGGUCUTT 13474.5S1796GACCCACCGAAUGUGCAAATT UUUGCACAUUCGGUGGGUCTT 13474.5S1797UGUGCAAAUACACACAAUCTT GAUUGUGUGUAUUUGCACATT 13429.2S1798AUACACACAAUCGACGGCUTT AGCCGUCGAUUGUGUGUAUTT 13459.4S1799UACACACAAUCGACGGCUCTT GAGCCGUCGAUUGUGUGUATT 13474.5S1800UCGACGGCUCUUCAGGAGUTT ACUCCUGAAGAGCCGUCGATT 13489.6S1801UCCAGCAAUGGAUCCAAUUTT AAUUGGAUCCAUUGCUGGATT 13444.3S1802UGGAUCCAAUUUAUGAUGATT UCAUCAUAAAUUGGAUCCATT 13414.1S1803UUUAUGAUGAGCCGACGACTT GUCGUCGGCUCAUCAUAAATT 13459.4S1804GCACAAGAAAGUGAGUACGTT CGUACUCACUUUCUUGUGCTT 13459.4S1805GAAAGUGAGUACGAACUUATT UAAGUUCGUACUCACUUUCTT 13429.2S1806AGUGAGUACGAACUUAUGUTT ACAUAAGUUCGUACUCACUTT 13429.2S1807GUGAGUACGAACUUAUGUATT UACAUAAGUUCGUACUCACTT 13429.2S1808CUUAUGUACUCAUUCGUUUTT AAACGAAUGAGUACAUAAGTT 13414.1S1809GAAACAGGUACGUUAAUAGTT CUAUUAACGUACCUGUUUCTT 13429.2S1810ACAGGUACGUUAAUAGUUATT UAACUAUUAACGUACCUGUTT 13414.1S1811CAGGUACGUUAAUAGUUAATT UUAACUAUUAACGUACCUGTT 13414.1S1812UAGUUAAUAGCGUACUUCUTT AGAAGUACGCUAUUAACUATT 13414.1S1813UAGCGUACUUCUUUUUCUUTT AAGAAAAAGAAGUACGCUATT 13414.1S1814CGUGAGUUUAGUAAAACCATT UGGUUUUACUAAACUCACGTT 13429.2S1815AACCAACGGUUUACGUCUATT UAGACGUAAACCGUUGGUUTT 13444.3
S1816ACCAACGGUUUACGUCUACTT GUAGACGUAAACCGUUGGUTT 13459.4S1817CCAACGGUUUACGUCUACUTT AGUAGACGUAAACCGUUGGTT 13459.4S1818CGGUUUACGUCUACUCGCGTT CGCGAGUAGACGUAAACCGTT 13489.6S1819AAAUCUGAACUCUUCUGAATT UUCAGAAGAGUUCAGAUUUTT 13414.1S1820AAUCUGAACUCUUCUGAAGTT CUUCAGAAGAGUUCAGAUUTT 13429.2S1821AUCUGAACUCUUCUGAAGGTT CCUUCAGAAGAGUUCAGAUTT 13444.3S1822UCUGAACUCUUCUGAAGGATT UCCUUCAGAAGAGUUCAGATT 13444.3S1823CUCUUCUGAAGGAGUUCCUTT AGGAACUCCUUCAGAAGAGTT 13459.4S1824GGAGUUCCUGAUCUUCUGGTT CCAGAAGAUCAGGAACUCCTT 13474.5上表中S1748-S1770SiRNA的目标基因是UP1，S1771-S1803SiRNA的目标基因是UP1和UP2，S1804-S1808SiRNA的目标基因是UP2，S1809-S1811SiRNA的目标基因是UP2和E，S1812-S1824SiRNA的目标基因是E。
表6、针对第四编码区的SiRNA分子SiRNA序号 正义链序列 反义链序列MWS1825 CGGUACUAUUACCGUUGAGTT CUCAACGGUAAUAGUACCGTT 13459.4S1826 ACAACUCCUGGAACAAUGGTT CCAUUGUUCCAGGAGUUGUTT 13459.4S1827 CAACUCCUGGAACAAUGGATT UCCAUUGUUCCAGGAGUUGTT 13459.4S1828 CUCCUGGAACAAUGGAACCTT GGUUCCAUUGUUCCAGGAGTT 13474.5S1829 CAAUGGAACCUAGUAAUAGTT CUAUUACUAGGUUCCAUUGTT 13429.2S1830 UGGAACCUAGUAAUAGGUUTT AACCUAUUACUAGGUUCCATT 13429.2S1831 CCUAGUAAUAGGUUUCCUATT UAGGAAACCUAUUACUAGGTT 13429.2S1832 UAGGUUUCCUAUUCCUAGCTT GCUAGGAAUAGGAAACCUATT 13444.3S1833 UUUGCCUAUUCUAAUCGGATT UCCGAUUAGAAUAGGCAAATT 13429.2S1834 UCGGAACAGGUUUUUGUACTT GUACAAAAACCUGUUCCGATT 13444.3S1835 UAAAGCUUGUUUUCCUCUGTT CAGAGGAAAACAAGCUUUATT 13429.2S1836 AGCUUGUUUUCCUCUGGCUTT AGCCAGAGGAAAACAAGCUTT 13459.4S1837 GCUUGUUUUCCUCUGGCUCTT GAGCCAGAGGAAAACAAGCTT 13474.5S1838 CACUUGCUUGUUUUGUGCUTT AGCACAAAACAAGCAAGUGTT 13444.3S1839 UUAAUUGGGUGACUGGCGGTT CCGCCAGUCACCCAAUUAATT 13474.5S1840 UUGGGUGACUGGCGGGAUUTT AAUCCCGCCAGUCACCCAATT 13489.6S1841 UGGCUUGUAUUGUAGGCUUTT AAGCCUACAAUACAAGCCATT 13444.3S1842 UGUGGUCAUUCAACCCAGATT UCUGGGUUGAAUGACCACATT 13459.4S1843 CCCAGAAACAAACAUUCUUTT AAGAAUGUUUGUUUCUGGGTT 13429.2S1844 ACAAACAUUCUUCUCAAUGTT CAUUGAGAAGAAUGUUUGUTT 13414.1S1845 CAAACAUUCUUCUCAAUGUTT ACAUUGAGAAGAAUGUUUGTT 13414.1S1846 ACAUUCUUCUCAAUGUGCCTT GGCACAUUGAGAAGAAUGUTT 13444.3S1847 CAUUCUUCUCAAUGUGCCUTT AGGCACAUUGAGAAGAAUGTT 13444.3S1848 UGUGCCUCUCCGGGGGACATT UGUCCCCCGGAGAGGCACATT 13519.8S1849 UUGUGACCAGACCGCUCAUTT AUGAGCGGUCUGGUCACAATT 13474.5S1850 AGUGAACUUGUCAUUGGUGTT CACCAAUGACAAGUUCACUTT 13444.3S1851 GUGAACUUGUCAUUGGUGCTT GCACCAAUGACAAGUUCACTT 13459.4S1852 CUUGUCAUUGGUGCUGUGATT UCACAGCACCAAUGACAAGTT 13459.4
S1853GGACCUGCCAAAAGAGAUCTT GAUCUCUUUUGGCAGGUCCTT 13474.5S1854AAGAGAUCACUGUGGCUACTT GUAGCCACAGUGAUCUCUUTT 13459.4S1855AGAGAUCACUGUGGCUACATT UGUAGCCACAGUGAUCUCUTT 13459.4S1856GAGAUCACUGUGGCUACAUTT AUGUAGCCACAGUGAUCUCTT 13459.4S1857AUUAGGAGCGUCGCAGCGUTT ACGCUGCGACGCUCCUAAUTT 13489.6S1858UUAGGAGCGUCGCAGCGUGTT CACGCUGCGACGCUCCUAATT 13504.7S1859CCGCUACCGUAUUGGAAACTT GUUUCCAAUACGGUAGCGGTT 13474.5S1860AUUAAAUACAGACCACGCCTT GGCGUGGUCUGUAUUUAAUTT 13444.3S1861UUAAAUACAGACCACGCCGTT CGGCGUGGUCUGUAUUUAATT 13459.4S1862AUACAGACCACGCCGGUAGTT CUACCGGCGUGGUCUGUAUTT 13489.6S1863UACAGACCACGCCGGUAGCTT GCUACCGGCGUGGUCUGUATT 13504.7S1864CGACAAUAUUGCUUUGCUATT UAGCAAAGCAAUAUUGUCGTT 13429.2S1865UAUUGCUUUGCUAGUACAGTT CUGUACUAGCAAAGCAAUATT 13429.2上表中的SiRNA的目标基因为M。
表7、针对第五编码区的SiRNA分子SiRNA序号 正义链序列 反义链序列 MWS1866 UAAGUUCAAUAGUGAGACATT UGUCUCACUAUUGAACUUATT 13414.1S1867 GUUCAAUAGUGAGACAAUUTT AAUUGUCUCACUAUUGAACTT 13414.1S1868 GCCUCUAACUAAGAAGAAUTT AUUCUUCUUAGUUAGAGGCTT 13429.2S1869 CUAAGAAGAAUUAUUCGGATT UCCGAAUAAUUCUUCUUAGTT 13414.1S1870 GAAGAAUUAUUCGGAGUUATT UAACUCCGAAUAAUUCUUCTT 13414.1S1871 GAAUUAUUCGGAGUUAGAUTT AUCUAACUCCGAAUAAUUCTT 13414.1S1872 UUAUUCGGAGUUAGAUGAUTT AUCAUCUAACUCCGAAUAATT 13414.1S1873 GAACCUAUGGAGUUAGAUUTT AAUCUAACUCCAUAGGUUCTT 13429.2S1874 CCUAUGGAGUUAGAUUAUCTT GAUAAUCUAACUCCAUAGGTT 13429.2上表中的SiRNA的目标基因为UP3。
表8、针对第六编码区的SiRNA分子SiRNA序号 正义链序列 反义链序列 MWS1875 AAUUAUUCUCUUCCUGACATT UGUCAGGAAGAGAAUAAUUTT 13414.1S1876 AUUAUUCUCUUCCUGACAUTT AUGUCAGGAAGAGAAUAAUTT 13414.1S1877 UUAUUCUCUUCCUGACAUUTT AAUGUCAGGAAGAGAAUAATT 13414.1S1878 AAGAACCUUGCCCAUCAGGTT CCUGAUGGGCAAGGUUCUUTT 13474.5S1879 AGAACCUUGCCCAUCAGGATT UCCUGAUGGGCAAGGUUCUTT 13474.5S1880 GAACCUUGCCCAUCAGGAATT UUCCUGAUGGGCAAGGUUCTT 13474.5S1881 CCUUGCCCAUCAGGAACAUTT AUGUUCCUGAUGGGCAAGGTT 13474.5S1882 CAUACGAGGGCAAUUCACCTT GGUGAAUUGCCCUCGUAUGTT 13474.5S1883 UUCACCAUUUCACCCUCUUTT AAGAGGGUGAAAUGGUGAATT 13444.3S1884 UAAAUUUGCACUAACUUGCTT GCAAGUUAGUGCAAAUUUATT 13414.1S1885 AUUUGCACUAACUUGCACUTT AGUGCAAGUUAGUGCAAAUTT 13429.2S1886 UUUGCACUAACUUGCACUATT UAGUGCAAGUUAGUGCAAATT 13429.2S1887 CUUGCACUAGCACACACUUTT AAGUGUGUGCUAGUGCAAGTT 13459.4S1888 GAUCAGUUUCACCAAAACUTT AGUUUUGGUGAAACUGAUCTT 13429.2
S1889AACUUUUCAUCAGACAAGATTUCUUGUCUGAUGAAAAGUUTT13414.1S1890ACUUUUCAUCAGACAAGAGTTCUCUUGUCUGAUGAAAAGUTT13429.2S1891CUUUUCAUCAGACAAGAGGTTCCUCUUGUCUGAUGAAAAGTT13444.3S1892GAGGAGGUUCAACAAGAGCTTGCUCUUGUUGAACCUCCUCTT13474.5S1893CAAGAGCUCUACUCGCCACTTGUGGCGAGUAGAGCUCUUGTT13489.6S1894GAGCUCUACUCGCCACUUUTTAAAGUGGCGAGUAGAGCUCTT13474.5S1895UACUUUGCUUCACCAUUAATTUUAAUGGUGAAGCAAAGUATT13414.1上表中的SiRNA的目标基因为UP4。
表9、针对第七编码区的SiRNA分子SiRNA序号 正义链序列 反义链序列 MWS1896 UGGACCCCAAUCAAACCAATTUUGGUUUGAUUGGGGUCCATT 13459.4S1897 UCAAACCAACGUAGUGCCCTTGGGCACUACGUUGGUUUGATT 13474.5S1898 ACCAACGUAGUGCCCCCCGTTCGGGGGGCACUACGUUGGUTT 13519.8S1899 CGUAGUGCCCCCCGCAUUATTUAAUGCGGGGGGCACUACGTT 13504.7S1900 CUGACAAUAACCAGAAUGGTTCCAUUCUGGUUAUUGUCAGTT 13444.3S1901 UAACCAGAAUGGAGGACGCTTCCGUCCUCCAUUCUGGUUATT 13474.5S1902 UGGAGGACGCAAUGGGGCATTUGCCCCAUUGCGUCCUCCATT 13504.7S1903 UGGGGCAAGGCCAAAACAGTTCUGUUUUGGCCUUGCCCCATT 13489.6S1904 GGCCAAAACAGCGCCGACCTTGGUCGGCGCUGUUUUGGCCTT 13519.8S1905 AACAGCGCCGACCCCAAGGTTCCUUGGGGUCGGCGCUGUUTT 13519.8S1906 ACAGCGCCGACCCCAAGGUTTACCUUGGGGUCGGCGCUGUTT 13519.8S1907 CAGCGCCGACCCCAAGGUUTTAACCUUGGGGUCGGCGCUGTT 13519.8S1908 GGUUUACCCAAUAAUACUGTTCAGUAUUAUUGGGUAAACCTT 13429.2S1909 UAAUACUGCGUCUUGGUUCTTGAACCAAGACGCAGUAUUATT 13444.3S1910 UACUGCGUCUUGGUUCACATTUGUGAACCAAGACGCAGUATT 13459.4S1911 GGAGGAACUUAGAUUCCCUTTAGGGAAUCUAAGUUCCUCCTT 13459.4S1912 CUUAGAUUCCCUCGAGGCCTTGGCCUCGAGGGAAUCUAAGTT 13489.6S1913 UCAACACCAAUAGUGGUCCTTGGACCACUAUUGGUGUUGATT 13459.4S1914 CACCAAUAGUGGUCCAGAUTTAUCUGGACCACUAUUGGUGTT 13459.4S1915 UAGUGGUCCAGAUGACCAATTUUGGUCAUCUGGACCACUATT 13459.4S1916 AUUGGCUACUACCGAAGAGTTCUCUUCGGUAGUAGCCAAUTT 13459.4S1917 UUGGCUACUACCGAAGAGCTTGCUCUUCGGUAGUAGCCAATT 13474.5S1918 GAGCUACCCGACGAGUUCGTTCGAACUCGUCGGGUAGCUCTT 13504.7S1919 AAUGAAAGAGCUCAGCCCCTTGGGGCUGAGCUCUUUCAUUTT 13474.5S1920 AUGAAAGAGCUCAGCCCCATTUGGGGCUGAGCUCUUUCAUTT 13474.5S1921 UGAAAGAGCUCAGCCCCAGTTCUGGGGCUGAGCUCUUUCATT 13489.6S1922 AGAGCUCAGCCCCAGAUGGTTCCAUCUGGGGCUGAGCUCUTT 13504.7S1923 GAGCUCAGCCCCAGAUGGUTTACCAUCUGGGGCUGAGCUCTT 13504.7S1924 CUGGCCCAGAAGCUUCACUTTAGUGAAGCUUCUGGGCCAGTT 13489.6S1925 GCUUCACUUCCCUACGGCGTTCGCCGUAGGGAAGUGAAGCTT 13504.7S1926 CAAAGAAGGCAUCGUAUGGTTCCAUACGAUGCCUUCUUUGTT 13459.4S1927 AGAAGGCAUCGUAUGGGUUTTAACCCAUACGAUGCCUUCUTT 13459.4S1928 GAAGGCAUCGUAUGGGUUGTTCAACCCAUACGAUGCCUUCTT 13474.5S1929 GGCAUCGUAUGGGUUGCAATTUUGCAACCCAUACGAUGCCTT 13474.5
S1930 CUGAGGGAGCCUUGAAUACTT GUAUUCAAGGCUCCCUCAGTT 13474.5S1931 UACACCCAAAGACCACAUUTT AAUGUGGUCUUUGGGUGUATT 13444.3S1932 AGACCACAUUGGCACCCGCTT GCGGGUGCCAAUGUGGUCUTT 13504.7S1933 GACCACAUUGGCACCCGCATT UGCGGGUGCCAAUGUGGUCTT 13504.7S1934 UCCUAAUAACAAUGCUGCCTT GGCAGCAUUGUUAUUAGGATT 13444.3S1935 UAACAAUGCUGCCACCGUGTT CACGGUGGCAGCAUUGUUATT 13474.5S1936 CAAUGCUGCCACCGUGCUATT UAGCACGGUGGCAGCAUUGTT 13489.6S1937 UGCUGCCACCGUGCUACAATT UUGUAGCACGGUGGCAGCATT 13489.6S1938 CUUCCUCAAGGAACAACAUTT AUGUUGUUCCUUGAGGAAGTT 13444.3S1939 GGAACAACAUUGCCAAAAGTT CUUUUGGCAAUGUUGUUCCTT 13444.3S1940 CAACAUUGCCAAAAGGCUUTT AAGCCUUUUGGCAAUGUUGTT 13444.3S1941 CAUUGCCAAAAGGCUUCUATT UAGAAGCCUUUUGGCAAUGTT 13444.3S1942 AAGGCUUCUACGCAGAGGGTT CCCUCUGCGUAGAAGCCUUTT 13489.6S1943 GGCUUCUACGCAGAGGGAATT UUCCCUCUGCGUAGAAGCCTT 13489.6S1944 GCAGAGGCGGCAGUCAAGCTT GCUUGACUGCCGCCUCUGCTT 13519.8S1945 GCCUCUUCUCGCUCCUCAUTT AUGAGGAGCGAGAAGAGGCTT 13489.6S1946 UUCAAGAAAUUCAACUCCUTT AGGAGUUGAAUUUCUUGAATT 13414.1S1947 GAAAUUCAACUCCUGGCAGTT CUGCCAGGAGUUGAAUUUCTT 13459.4S1948 AUUCAACUCCUGGCAGCAGTT CUGCUGCCAGGAGUUGAAUTT 13474.5S1949 UUCAACUCCUGGCAGCAGUTT ACUGCUGCCAGGAGUUGAATT 13474.5S1950 CUCCUGGCAGCAGUAGGGGTT CCCCUACUGCUGCCAGGAGTT 13519.8S1951 AUUCUCCUGCUCGAAUGGCTT GCCAUUCGAGCAGGAGAAUTT 13474.5S1952 UUCUCCUGCUCGAAUGGCUTT AGCCAUUCGAGCAGGAGAATT 13474.5S1953 UGGCUAGCGGAGGUGGUGATT UCACCACCUCCGCUAGCCATT 13504.7S1954 ACUGCCCUCGCGCUAUUGCTT GCAAUAGCGCGAGGGCAGUTT 13504.7S1955 CUGCCCUCGCGCUAUUGCUTT AGCAAUAGCGCGAGGGCAGTT 13504.7S1956 CCAGCUUGAGAGCAAAGUUTT AACUUUGCUCUCAAGCUGGTT 13459.4S1957 AGUUUCUGGUAAAGGCCAATT UUGGCCUUUACCAGAAACUTT 13444.3S1958 GUUUCUGGUAAAGGCCAACTT GUUGGCCUUUACCAGAAACTT 13459.4S1959 AGGCCAACAACAACAAGGCTT GCCUUGUUGUUGUUGGCCUTT 13474.5S1960 GGCCAACAACAACAAGGCCTT GGCCUUGUUGUUGUUGGCCTT 13489.6S1961 CAACAACAAGGCCAAACUGTT CAGUUUGGCCUUGUUGUUGTT 13459.4S1962 CAACAAGGCCAAACUGUCATT UGACAGUUUGGCCUUGUUGTT 13459.4S1963 CAAGGCCAAACUGUCACUATT UAGUGACAGUUUGGCCUUGTT 13459.4S1964 GGCCAAACUGUCACUAAGATT UCUUAGUGACAGUUUGGCCTT 13459.4S1965 ACUGUCACUAAGAAAUCUGTT CAGAUUUCUUAGUGACAGUTT 13429.2S1966 CUGUCACUAAGAAAUCUGCTT GCAGAUUUCUUAGUGACAGTT 13444.3S1967 GAAAUCUGCUGCUGAGGCATT UGCCUCAGCAGCAGAUUUCTT 13474.5S1968 AUCUGCUGCUGAGGCAUCUTT AGAUGCCUCAGCAGCAGAUTT 13474.5S1969 UCUGCUGCUGAGGCAUCUATT UAGAUGCCUCAGCAGCAGATT 13474.5S1970 AAAGCCUCGCCAAAAACGUTT ACGUUUUUGGCGAGGCUUUTT 13459.4S1971 AAGCCUCGCCAAAAACGUATT UACGUUUUUGGCGAGGCUUTT 13459.4S1972 AGCCUCGCCAAAAACGUACTT GUACGUUUUUGGCGAGGCUTT 13474.5S1973 GCCUCGCCAAAAACGUACUTT AGUACGUUUUUGGCGAGGCTT 13474.5
S1974 AAACGUACUGCCACAAAACTT GUUUUGUGGCAGUACGUUUTT 13444.3S1975 AACGUACUGCCACAAAACATT UGUUUUGUGGCAGUACGUUTT 13444.3S1976 ACGUACUGCCACAAAACAGTT CUGUUUUGUGGCAGUACGUTT 13459.4S1977 CGUACUGCCACAAAACAGUTT ACUGUUUUGUGGCAGUACGTT 13459.4S1978 AACAGUACAACGUCACUCATT UGAGUGACGUUGUACUGUUTT 13444.3S1979 ACAGUACAACGUCACUCAATT UUGAGUGACGUUGUACUGUTT 13444.3S1980 CAGUACAACGUCACUCAAGTT CUUGAGUGACGUUGUACUGTT 13459.4S1981 CGUCACUCAAGCAUUUGGGTT CCCAAAUGCUUGAGUGACGTT 13474.5S1982 GCAUUUGGGAGACGUGGUCTT GACCACGUCUCCCAAAUGCTT 13489.6S1983 CAAACCCAAGGAAAUUUCGTT CGAAAUUUCCUUGGGUUUGTT 13444.3S1984 ACCCAAGGAAAUUUCGGGGTT CCCCGAAAUUUCCUUGGGUTT 13474.5S1985 CCCAAGGAAAUUUCGGGGATT UCCCCGAAAUUUCCUUGGGTT 13474.5S1986 GGAAAUUUCGGGGACCAAGTT CUUGGUCCCCGAAAUUUCCTT 13474.5S1987 AUUUCGGGGACCAAGACCUTT AGGUCUUGGUCCCCGAAAUTT 13474.5S1988 UUUCGGGGACCAAGACCUATT UAGGUCUUGGUCCCCGAAATT 13474.5S1989 GACCUAAUCAGACAAGGAATT UUCCUUGUCUGAUUAGGUCTT 13444.3S1990 UCAGACAAGGAACUGAUUATT UAAUCAGUUCCUUGUCUGATT 13429.2S1991 GGAACUGAUUACAAACAUUTT AAUGUUUGUAAUCAGUUCCTT 13414.1S1992 CUGAUUACAAACAUUGGCCTT GGCCAAUGUUUGUAAUCAGTT 13444.3S1993 ACAUUGGCCGCAAAUUGCATT UGCAAUUUGCGGCCAAUGUTT 13459.4S1994 CAUUGGCCGCAAAUUGCACTT GUGCAAUUUGCGGCCAAUGTT 13474.5S1995 AUUGCACAAUUUGCUCCAATT UUGGAGCAAAUUGUGCAAUTT 13429.2S1996 UUGCACAAUUUGCUCCAAGTT CUUGGAGCAAAUUGUGCAATT 13444.3S1997 UUUGCUCCAAGUGCCUCUGTT CAGAGGCACUUGGAGCAAATT 13474.5S1998 GUGCCUCUGCAUUCUUUGGTT CCAAAGAAUGCAGAGGCACTT 13474.5S1999 UGUCACGCAUUGGCAUGGATT UCCAUGCCAAUGCGUGACATT 13474.5S2000 GUCACACCUUCGGGAACAUTT AUGUUCCCGAAGGUGUGACTT 13474.5S2001 CAUGGCUGACUUAUCAUGGTT CCAUGAUAAGUCAGCCAUGTT 13459.4S2002 AUUGGAUGACAAAGAUCCATT UGGAUCUUUGUCAUCCAAUTT 13429.2S2003 UUGGAUGACAAAGAUCCACTT GUGGAUCUUUGUCAUCCAATT 13444.3S2004 AGAUCCACAAUUCAAAGACTT GUCUUUGAAUUGUGGAUCUTT 13429.2S2005 GAUCCACAAUUCAAAGACATT UGUCUUUGAAUUGUGGAUCTT 13429.2S2006 UUCAAAGACAACGUCAUACTT GUAUGACGUUGUCUUUGAATT 13429.2S2007 AGACAACGUCAUACUGCUGTT CAGCAGUAUGACGUUGUCUTT 13459.4S2008 GACAACGUCAUACUGCUGATT UCAGCAGUAUGACGUUGUCTT 13459.4S2009 CGUCAUACUGCUGAACAAGTT CUUGUUCAGCAGUAUGACGTT 13459.4S2010 CAAGCACAUUGACGCAUACTT GUAUGCGUCAAUGUGCUUGTT 13459.4S2011 GCACAUUGACGCAUACAAATT UUUGUAUGCGUCAAUGUGCTT 13444.3S2012 AACAUUCCCACCAACAGAGTT CUCUGUUGGUGGGAAUGUUTT 13459.4S2013 ACAUUCCCACCAACAGAGCTT GCUCUGUUGGUGGGAAUGUTT 13474.5S2014 CAUUCCCACCAACAGAGCCTT GGCUCUGUUGGUGGGAAUGTT 13489.6S2015 CAGAGCCUAAAAAGGACAATT UUGUCCUUUUUAGGCUCUGTT 13444.3S2016 AGGACAAAAAGAAAAAGACTT GUCUUUUUCUUUUUGUCCUTT 13414.1S2017 GGACAAAAAGAAAAAGACUTT AGUCUUUUUCUUUUUGUCCTT 13414.1
S2018 AAGAAAAAGACUGAUGAAGTT CUUCAUCAGUCUUUUUCUUTT 13414.1S2019 AGAAAAAGACUGAUGAAGCTT GCUUCAUCAGUCUUUUUCUTT 13429.2S2020 GAAAAAGACUGAUGAAGCUTT AGCUUCAUCAGUCUUUUUCTT 13429.2S2021 AAAGACUGAUGAAGCUCAGTT CUGAGCUUCAUCAGUCUUUTT 13444.3S2022 AAGACUGAUGAAGCUCAGCTT GCUGAGCUUCAUCAGUCUUTT 13459.4S2023 AGACUGAUGAAGCUCAGCCTT GGCUGAGCUUCAUCAGUCUTT 13474.5S2024 GACUGAUGAAGCUCAGCCUTT AGGCUGAGCUUCAUCAGUCTT 13474.5S2025 GCUCAGCCUUUGCCGCAGATT UCUGCGGCAAAGGCUGAGCTT 13504.7S2026 AAGAAGCAGCCCACUGUGATT UCACAGUGGGCUGCUUCUUTT 13474.5S2027 AGAAGCAGCCCACUGUGACTT GUCACAGUGGGCUGCUUCUTT 13489.6S2028 GAAGCAGCCCACUGUGACUTT AGUCACAGUGGGCUGCUUCTT 13489.6S2029 GCAGCCCACUGUGACUCUUTT AAGAGUCACAGUGGGCUGCTT 13489.6S2030 CUUCAAAAUUCCAUGAGUGTT CACUCAUGGAAUUUUGAAGTT 13429.2S2031 AAUUCCAUGAGUGGAGCUUTT AAGCUCCACUCAUGGAAUUTT 13444.3S2032 AUUCCAUGAGUGGAGCUUCTT GAAGCUCCACUCAUGGAAUTT 13459.4S2033 UUCCAUGAGUGGAGCUUCUTT AGAAGCUCCACUCAUGGAATT 13459.4上表中S1896-S1921SiRNA的目标基因是UP5和N，S1922-S2033SiRNA的目标基因是N。
对于以上所说的同源度的数值，以80％以上为更佳。本发明所说之同源度是指任何攻击SARS病毒的SiRNA，其核苷酸序列和本发明所说的核苷酸序列(I)的正义链或负义链相应位置上的核苷酸中的15个以上(即大于70％)或17个以上(即大于80％)相同。
本发明所提供的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)还包括针对以上所提到的小干扰RNA分子(SiRNA)的序列的任何部份或全部经化学修饰后所形成的的小干扰RNA分子。
所述化学修饰包括主要包括以下三类第一、对连接相邻两个核苷酸的磷酸二酯键的部份修饰或用其它任何化学键取代。典型的磷酸二酯键的部份修饰是将磷酸双键上的氧置换成硫(硫化)或其它元素，或将磷酸单键上的氧变成氮(氮化)或其它元素和化学基团；对磷酸二酯键本身的全部取代，也包括对其本身或其部份以及和它相连的两个核糖的部份或全部改变，典型的例证是将磷酸二酯键和两个相邻的核糖变成肽键，使得核酸变成肽核酸(peptide nucleicacid，PNA)；第二、对核甘中核糖的五元环进行改变或其侧链上的化学基团作修饰。改变核糖环的典型例证如将五元的核糖环变成六环的Morpholino环；对核糖侧链上的修饰主要是指将核糖2’位上OH变成其它元素(如卤素元素)，或用其它化学基团替代OH中的H(例如烷基)。第三、将核苷酸上的碱基环作整体的改变或侧链的修饰。
本发明所提供的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)可以应用于制备治疗SARS以及与SARS感染相关的任何疾病的药物中。


图1为SiRNA在自动核酸合成仪上每加上一个核甘酸所进行的四步反应示意图。
图2为在Beckman PACE 5010上分析得到的序号2 SiRNA的毛细管凝胶电泳法结果。其中横坐标表示滞留时间，纵坐标表示紫外吸收度。
具体实施例方式
实施例1本发明提供的小干扰RNA分子(SiRNA)的制备方法采用现有的固相化学合成法。该方法可参见Wincott F， DiRenzo A，Shaffer C，Grimm S，Tracz D，Workman C，Sweedler D，Gonzalez C，Scaringe S and Usman N.Synthesis，deprotection，analysis and purification of RNA and ribozymes. Nucleic AcidsRes. 1995，232677-84。
以表1之序号2的小干扰RNA分子(SiRNA)为例整个化学合成可大致分成四个的过程(1)寡聚核糖核酸的合成；(2)脱保护；(3)纯化分离；(4)脱盐退火无菌消毒。
具体制备操作如下(1)、寡聚核糖核酸的合成SiRNA的合成是在自动DNA/RNA合成仪(例如Applied Biosystems EXPEDITE 8909)上进行，根据序号2的小干扰RNA分子SiRNA的核酸序列(正义链5’-CUAAUUGCUGUCGCUUCCATT反义链5’-UGGAAGCGACAGCAAUUAGTT)的次序将对应的核苷酸逐个连接起来。由于SiRNA是由一段19聚的寡聚核糖核酸和一个2聚的脱氧胸苷酸组成。因此起始物为固相(CPG)连接的5’-O-对二甲氧基三苯甲基-胸苷(1-2umol)。具体每一个循环合成可分为四步来完成(图1)。第一步是将与固相连接的胸苷上5’位的保护基在3％三氯乙酸的作用下洗脱；第二步在活性催化剂S-乙基四唑的作用下，将5’-O-对二甲氧基三苯甲基-胸苷亚磷酰胺偶联到已脱去保护的上一个胸苷上，形成二胸苷亚磷酸三酯。偶合时间和偶合循环的次数均按仪器厂家提供程序来完成；第三步是将偶合的二胸苷亚磷酸三酯在0.05M碘水的作用下氧化成二胸苷磷酸三酯；第四步是乙酰化，将固相上的少量未反应的活性基团(例如羟基和胺基)在乙酸酐的作用下形成酯或酰胺。从而达到封闭作用，用以减少整体副产物的产生。重复此循环直至完成全部核酸序列的合成。
(1)脱保护将合成好的固相SiRNA放入一个可以密封的小瓶，并与加入1毫升的甲胺水溶液(10M，50％乙醇)，静置在室温。两小时后，取出溶液，并将固相CPG再次用乙醇；水和乙腈的混合液淋洗，并将淋洗液和前面取出的溶液合并一处，将其溶剂抽干。在小瓶中继续加入1毫升四丁基氟化铵的四氢呋喃溶液(1M)。将溶液在室温静置12个小时。脱去所有寡聚核糖核酸上的保护基(包括碱基，核苷磷酸和核苷2’位的硅烷化保护基)。再经过乙醇沉淀，产生SiRNA的粗产物。
(2)纯化分离将SiRNA的粗产物溶解在2毫升的乙酸铵的水溶液中，然后经过反相C18高压液相色谱的分离。运用梯度淋洗的方法，收集SiRNA的主产物(淋洗液A0.1M的乙酸铵；淋洗液b20％的0.1M的乙酸铵和80％的乙腈)。将SiRNA的主产物的溶剂除去，并加入5毫升80％乙酸水溶液，在室温静置15分钟。然后将此溶液进行阴离子交换的分离(DEAE-5PW，阴离子交换柱)，即可得到纯度在90％以上的SiRNA(梯度淋洗，淋洗液A0.025M的Tris-HCl，0.025M NaCl pH＝8，5％乙腈；淋洗液b0.025M的Tris-HCl，2.0M NaCl，pH＝8，5％乙腈)。
(3)脱盐退火无菌消毒纯化的SiRNA经过透析，除去盐份，SiRNA的溶液进行过滤消毒和干燥结晶。然后将正义链和反义链的寡聚核糖核酸进行退火处理形成稳定的双股交链的SiRNA。其方法是将正义链和反义链的寡聚核糖核酸混合溶解在1-2毫升的缓冲溶液中(10mM Tris，pH＝7.5-8.0，50mM NaCl)。将此溶液加热到95℃，然后缓缓将此溶液冷却致室温(此过程应不少于一个小时)。最后将此溶液存放在4℃冰箱中保存，以便随时可以使用。
经过纯化后的SiRNA的纯度和鉴定有两种比较常用的办法。其一用毛细管凝胶电泳法来鉴定SiRNA的纯度，该方法可参见Paulus A，Ohms JI.Analysis ofoligonucleotides by capillary gelelectrophoresis.J Chromatogr1990，507113-123。
对序号2的小干扰RNA分子的制备结果表明它的纯度大于95％(图2)。
其二是用MALDI-TOF质谱来准确测量其分子量，从而确定SiRNA的化学结构组成。
本发明所说的SiRNA都可以根据其序列采用上述方法制备，鉴定方法同上。
实施例2如上所述，修饰的种类可分三大类并且每一类中有许多变化，因此它们各自的合成方法不尽一样。这里列举两种最为常见的SiRNA修饰方法。并且，下述的方法并不限定本发明所述的有关对SiRNA修饰的保护范围。
1、硫化硫化是指将核苷磷酸二酯键上的一个氧原子转变成硫原子形成核苷硫代磷酸二酯。由于整个SiRNA的其它组成结构没有变化，因此它的合成和实施例1的SiRNA合成过程基本一样。只需将合成过程中的氧化反应变成硫化反应，在此反应中加入适当的硫化试剂，例如3H-1，2-benzodithiol-3-one 1，1-dioxide(又称Beaucage试剂)。
2、核苷2’位羟基的修饰核苷2’位羟基的修饰是指用各种饱和烷氧基或不饱和烷氧来取代核苷五员糖环上的2’位羟基。其中最常见的是用甲氧基来取代核苷2’位的羟基。SiRNA的核苷2’位甲氧基化的合成和实施例1的SiRNA的合成步骤基本一致，只需要在偶合反应中用2’-甲氧基核苷亚磷酰胺来取代2’-叔丁基二甲基硅氧基核苷亚磷酰胺即可。
序列表<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>1<211>29744<212>RNA<213>Coronavirus<220>
<221>misc_feature<222>1...29744<223>从已知SARS病毒全基因组RNA序列得到的SARS病毒的全基因组RNA的共同序列<400>1atattaggtt tttacctacc caggaaaagc caaccaacct cgatctcttg tagatctgtt 60ctctaaacga actttaaaat ctgtgtagct gtcgctcggc tgcatgccta gtgcacctac 120gcagtataaa caataataaa ttttactgtc gttgacaaga aacgagtaac tcgtccctct 180tctgcagact gcttacggtt tcgtccgtgt tgcagtcgat catcagcata cctaggtttc 240gtccgggtgt gaccgaaagg taagatggag agccttgttc ttggtgtcaa cgagaaaaca 300cacgtccaac tcagtttgcc tgtccttcag gttagagacg tgctagtgcg tggcttcggg 360gactctgtgg aagaggccct atcggaggca cgtgaacacc tcaaaaatgg cacttgtggt 420ctagtagagc tggaaaaagg cgtactgccc cagcttgaac agccctatgt gttcattaaa 480cgttctgatg ccttaagcac caatcacggc cacaaggtcg ttgagctggt tgcagaaatg 540gacggcattc agtacggtcg tagcggtata acactgggag tactcgtgcc acatgtgggc 600gaaaccccaa ttgcataccg caatgttctt cttcgtaaga acggtaataa gggagccggt 660
ggtcatagct atggcatcga tctaaagtct tatgacttag gtgacgagct tggcactgat 720cccattgaag attatgaaca aaactggaac actaagcatg gcagtggtgc actccgtgaa 780ctcactcgtg agctcaatgg aggtgcagtc actcgctatg tcgacaacaa tttctgtggc 840ccagatgggt accctcttga ttgcatcaaa gattttctcg cacgcgcggg caagtcaatg 900tgcactcttt ccgaacaact tgattacatc gagtcgaaga gaggtgtcta ctgctgccgt 960gaccatgagc atgaaattgc ctggttcact gagcgctctg ataagagcta cgagcaccag 1020acacccttcg aaattaagag tgccaagaaa tttgacactt tcaaagggga atgcccaaag 1080tttgtgtttc ctcttaactc aaaagtcaaa gtcattcaac cacgtgttga aaagaaaaag 1140actgagggtt tcatggggcg tatacgctct gtgtaccctg ttgcatctcc acaggagtgt 1200aacaatatgc acttgtctac cttgatgaaa tgtaatcatt gcgatgaagt ttcatggcag 1260acgtgcgact ttctgaaagc cacttgtgaa cattgtggca ctgaaaattt agttattgaa 1320ggacctacta catgtgggta cctacctact aatgctgtag tgaaaatgcc atgtcctgcc 1380tgtcaagacc cagagattgg acctgagcat agtgttgcag attatcacaa ccactcaaac 1440attgaaactc gactccgcaa gggaggtagg actagatgtt ttggaggctg tgtgtttgcc 1500tatgttggct gctataataa gcgtgcctac tgggttcctc gtgctagtgc tgatattggc 1560tcaggccata ctggcattac tggtgacaat gtggagacct tgaatgagga tctccttgag 1620atactgagtc gtgaacgtgt taacattaac attgttggcg attttcattt gaatgaagag 1680gttgccatca ttttggcatc tttctctgct tctacaagtg cctttattga cactataaag 1740agtcttgatt acaagtcttt caaaaccatt gttgagtcct gcggtaacta taaagttacc 1800aagggaaagc ccgtaaaagg tgcttggaac attggacaac agagatcagt tttaacacca 1860ctgtgtggtt ttccctcaca ggctgctggt gttatcagat caatttttgc gcgcacactt 1920gatgcagcaa accactcaat tcctgatttg caaagagcag ctgtcaccat acttgatggt 1980
atttctgaac agtcattacg tcttgtcgac gccatggttt atacttcaga cctgctcacc 2040aacagtgtca ttattatggc atatgtaact ggtggtcttg tacaacagac ttctcagtgg 2100ttgtctaatc ttttgggcac tactgttgaa aaactcaggc ctatctttga atggattgag 2160gcgaaactta gtgcaggagt tgaatttctc aaggatgctt gggagattct caaatttctc 2220attacaggtg tttttgacat cgtcaagggt caaatacagg ttgcttcaga taacatcaag 2280gattgtgtaa aatgcttcat tgatgttgtt aacaaggcac tcgaaatgtg cattgatcaa 2340gtcactatcg ctggcgcaaa gttgcgatca ctcaacttag gtgaagtctt catcgctcaa 2400agcaagggac tttaccgtca gtgtatacgt ggcaaggagc agctgcaact actcatgcct 2460cttaaggcac caaaagaagt aacctttctt gaaggtgatt cacatgacac agtacttacc 2520tctgaggagg ttgttctcaa gaacggtgaa ctcgaagcac tcgagacgcc cgttgatagc 2580ttcacaaatg gagctatcgt tggcacacca gtctgtgtaa atggcctcat gctcttagag 2640attaaggaca aagaacaata ctgcgcattg tctcctggtt tactggctac aaacaatgtc 2700tttcgcttaa aagggggtgc accaattaaa ggtgtaacct ttggagaaga tactgtttgg 2760gaagttcaag gttacaagaa tgtgagaatc acatttgagc ttgatgaacg tgttgacaaa 2820gtgcttaatg aaaagtgctc tgtctacact gttgaatccg gtaccgaagt tactgagttt 2880gcatgtgttg tagcagaggc tgttgtgaag actttacaac cagtttctga tctccttacc 2940aacatgggta ttgatcttga tgagtggagt gtagctacat tctacttatt tgatgatgct 3000ggtgaagaaa acttttcatc acgtatgtat tgttcctttt accctccaga tgaggaagaa 3060gaggacgatg cagagtgtga ggaagaagaa attgatgaaa cctgtgaaca tgagtacggt 3120acagaggatg attatcaagg tctccctctg gaatttggtg cctcagctga aacagttcga 3180gttgaggaag aagaagagga agactggctg gatgatacta ctgagcaatc agagattgag 3240ccagaaccag aacctacacc tgaagaacca gttaatcagt ttactggtta tttaaaactt 3300
actgacaatg ttgccattaa atgtgttgac atcgttaagg aggcacaaag tgctaatcct 3360atggtgattg taaatgctgc taacatacac ctgaaacatg gtggtggtgt agcaggtgca 3420ctcaacaagg caaccaatgg tgccatgcaa aaggagagtg atgattacat taagctaaat 3480ggccctctta cagtaggagg gtcttgtttg ctttctggac ataatcttgc taagaagtgt 3540ctgcatgttg ttggacctaa cctaaatgca ggtgaggaca tccagcttct taaggcagca 3600tatgaaaatt tcaattcaca ggacatctta cttgcaccat tgttgtcagc aggcatattt 3660ggtgctaaac cacttcagtc tttacaagtg tgcgtgcaga cggttcgtac acaggtttat 3720attgcagtca atgacaaagc tctttatgag caggttgtca tggattatct tgataacctg 3780aagcctagag tggaagcacc taaacaagag gagccaccaa acacagaaga ttccaaaact 3840gaggagaaat ctgtcgtaca gaagcctgtc gatgtgaagc caaaaattaa ggcctgcatt 3900gatgaggtta ccacaacact ggaagaaact aagtttctta ccaataagtt actcttgttt 3960gctgatatca atggtaagct ttaccatgat tctcagaaca tgcttagagg tgaagatatg 4020tctttccttg agaaggatgc accttacatg gtaggtgatg ttatcactag tggtgatatc 4080acttgtgttg taataccctc caaaaaggct ggtggcacta ctgagatgct ctcaagagct 4140ttgaagaaag tgccagttga tgagtatata accacgtacc ctggacaagg atgtgctggt 4200tatacacttg aggaagctaa gactgctctt aagaaatgca aatctgcatt ttatgtacta 4260ccttcagaag cacctaatgc taaggaagag attctaggaa ctgtatcctg gaatttgaga 4320gaaatgcttg ctcatgctga agagacaaga aaattaatgc ctatatgcat ggatgttaga 4380gccataatgg caaccatcca acgtaagtat aaaggaatta aaattcaaga gggcatcgtt 4440gactatggtg tccgattctt cttttatact agtaaagagc ctgtagcttc tattattacg 4500aagctgaact ctctaaatga gccgcttgtc acaatgccaa ttggttatgt gacacatggt 4560tttaatcttg aagaggctgc gcgctgtatg cgttctctta aagctcctgc cgtagtgtca 4620
gtatcatcac cagatgctgt tactacatat aatggatacc tcacttcgtc atcaaagaca 4680tctgaggagc actttgtaga aacagtttct ttggctggct cttacagaga ttggtcctat 4740tcaggacagc gtacagagtt aggtgttgaa tttcttaagc gtggtgacaa aattgtgtac 4800cacactctgg agagccccgt cgagtttcat cttgacggtg aggttctttc acttgacaaa 4860ctaaagagtc tcttatccct gcgggaggtt aagactataa aagtgttcac aactgtggac 4920aacactaatc tccacacaca gcttgtggat atgtctatga catatggaca gcagtttggt 4980ccaacatact tggatggtgc tgatgttaca aaaattaaac ctcatgtaaa tcatgagggt 5040aagactttct ttgtactacc tagtgatgac acactacgta gtgaagcttt cgagtactac 5100catactcttg atgagagttt tcttggtagg tacatgtctg ctttaaacca cacaaagaaa 5160tggaaatttc ctcaagttgg tggtttaact tcaattaaat gggctgataa caattgttat 5220ttgtctagtg ttttattagc acttcaacag cttgaagtca aattcaatgc accagcactt 5280caagaggctt attatagagc ccgtgctggt gatgctgcta acttttgtgc actcatactc 5340gcttacagta ataaaactgt tggcgagctt ggtgatgtca gagaaactat gacccatctt 5400ctacagcatg ctaatttgga atctgcaaag cgagttctta atgtggtgtg taaacattgt 5460ggtcagaaaa ctactacctt aacgggtgta gaagctgtga tgtatatggg tactctatct 5520tatgataatc ttaagacagg tgtttccatt ccatgtgtgt gtggtcgtga tgctacacaa 5580tatctagtac aacaagagtc ttcttttgtt atgatgtctg caccacctgc tgagtataaa 5640ttacagcaag gtacattctt atgtgcgaat gagtacactg gtaactatca gtgtggtcat 5700tacactcata taactgctaa ggagaccctc tatcgtattg acggagctca ccttacaaag 5760atgtcagagt acaaaggacc agtgactgat gttttctaca aggaaacatc ttacactaca 5820accatcaagc ctgtgtcgta taaactcgat ggagttactt acacagagat tgaaccaaaa 5880ttggatgggt attataaaaa ggataatgct tactatacag agcagcctat agaccttgta 5940
ccaactcaac cattaccaaa tgcgagtttt gataatttca aactcacatg ttctaacaca 6000aaatttgctg atgatttaaa tcaaatgaca ggcttcacaa agccagcttc acgagagcta 6060tctgtcacat tcttcccaga cttgaatggc gatgtagtgg ctattgacta tagacactat 6120tcagcgagtt tcaagaaagg tgctaaatta ctgcataagc caattgtttg gcacattaac 6180caggctacaa ccaagacaac gttcaaacca aacacttggt gtttacgttg tctttggagt 6240acaaagccag tagatacttc aaattcattt gaagttctgg cagtagaaga cacacaagga 6300atggacaatc ttgcttgtga aagtcaacaa cccacctctg aagaagtagt ggaaaatcct 6360accatacaga aggaagtcat agagtgtgac gtgaaaacta ccgaagttgt aggcaatgtc 6420atacttaaac catcagatga aggtgttaaa gtaacacaag agttaggtca tgaggatctt 6480atggctgctt atgtggaaaa cacaagcatt accattaaga aacctaatga gctttcacta 6540gccttaggtt taaaaacaat tgccactcat ggtattgctg caattaatag tgttccttgg 6600agtaaaattt tggcttatgt caaaccattc ttaggacaag cagcaattac aacatcaaat 6660tgcgctaaga gattagcaca acgtgtgttt aacaattata tgccttatgt gtttacatta 6720ttgttccaat tgtgtacttt tactaaaagt accaattcta gaattagagc ttcactacct 6780acaactattg ctaaaaatag tgttaagagt gttgctaaat tatgtttgga tgccggcatt 6840aattatgtga agtcacccaa attttctaaa ttgttcacaa tcgctatgtg gctattgttg 6900ttaagtattt gcttaggttc tctaatctgt gtaactgctg cttttggtgt actcttatct 6960aattttggtg ctccttctta ttgtaatggc gttagagaat tgtatcttaa ttcgtctaac 7020gttactacta tggatttctg tgaaggttct tttccttgca gcatttgttt aagtggatta 7080gactcccttg attcttatcc agctcttgaa accattcagg tgacgatttc atcgtacaag 7140ctagacttga caattttagg tctggccgct gagtgggttt tggcatatat gttgttcaca 7200aaattctttt atttattagg tctttcagct ataatgcagg tgttctttgg ctattttgct 7260
agtcatttca tcagcaattc ttggctcatg tggtttatca ttagtattgt acaaatggca 7320cccgtttctg caatggttag gatgtacatc ttctttgctt ctttctacta catatggaag 7380agctatgttc atatcatgga tggttgcacc tcttcgactt gcatgatgtg ctataagcgc 7440aatcgtgcca cacgcgttga gtgtacaact attgttaatg gcatgaagag atctttctat 7500gtctatgcaa atggaggccg tggcttctgc aagactcaca attggaattg tctcaattgt 7560gacacatttt gcactggtag tacattcatt agtgatgaag ttgctcgtga tttgtcactc 7620cagtttaaaa gaccaatcaa ccctactgac cagtcatcgt atattgttga tagtgttgct 7680gtgaaaaatg gcgcgcttca cctctacttt gacaaggctg gtcaaaagac ctatgagaga 7740catccgctct cccattttgt caatttagac aatttgagag ctaacaacac taaaggttca 7800ctgcctatta atgtcatagt ttttgatggc aagtccaaat gcgacgagtc tgcttctaag 7860tctgcttctg tgtactacag tcagctgatg tgccaaccta ttctgttgct tgaccaagct 7920cttgtatcag acgttggaga tagtactgaa gtttccgtta agatgtttga tgcttatgtc 7980gacacctttt cagcaacttt tagtgttcct atggaaaaac ttaaggcact tgttgctaca 8040gctcacagcg agttagcaaa gggtgtagct ttagatggtg tcctttctac attcgtgtca 8100gctgcccgac aaggtgttgt tgataccgat gttgacacaa aggatgttat tgaatgtctc 8160aaactttcac atcactctga cttagaagtg acaggtgaca gttgtaacaa tttcatgctc 8220acctataata aggttgaaaa catgacgccc agagatcttg gcgcatgtat tgactgtaat 8280gcaaggcata tcaatgccca agtagcaaaa agtcacaatg tttcactcat ctggaatgta 8340aaagactaca tgtctttatc tgaacagctg cgtaaacaaa ttcgtagtgc tgccaagaag 8400aacaacatac cttttagact aacttgtgct acaactagac aggttgtcaa tgtcataact 8460actaaaatct cactcaaggg tggtaagatt gttagtactt gttttaaact tatgcttaag 8520gccacattat tgtgcgttct tgctgcattg gtttgttata tcgttatgcc agtacataca 8580
ttgtcaatcc atgatggtta cacaaatgaa atcattggtt acaaagccat tcaggatggt 8640gtcactcgtg acatcatttc tactgatgat tgttttgcaa ataaacatgc tggttttgac 8700gcatggttta gccagcgtgg tggttcatac aaaaatgaca aaagctgccc tgtagtagct 8760gctatcatta caagagagat tggtttcata gtgcctggct taccgggtac tgtgctgaga 8820gcaatcaatg gtgacttctt gcattttcta cctcgtgttt ttagtgctgt tggcaacatt 8880tgctacacac cttccaaact cattgagtat agtgattttg ctacctctgc ttgcgttctt 8940gctgctgagt gtacaatttt taaggatgct atgggcaaac ctgtgccata ttgttatgac 9000actaatttgc tagagggttc tatttcttat agtgagcttc gtccagacac tcgttatgtg 9060cttatggatg gttccatcat acagtttcct aacacttacc tggagggttc tgttagagta 9120gtaacaactt ttgatgctga gtactgtaga catggtacat gcgaaaggtc agaagtaggt 9180atttgcctat ctaccagtgg tagatgggtt cttaataatg agcattacag agctctatca 9240ggagttttct gtggtgttga tgcgatgaat ctcatagcta acatctttac tcctcttgtg 9300caacctgtgg gtgctttaga tgtgtctgct tcagtagtgg ctggtggtat tattgccata 9360ttggtgactt gtgctgccta ctactttatg aaattcagac gtgtttttgg tgagtacaac 9420catgttgttg ctgctaatgc acttttgttt ttgatgtctt tcactatact ctgtctggta 9480ccagcttaca gctttctgcc gggagtctac tcagtctttt acttgtactt gacattctat 9540ttcaccaatg atgtttcatt cttggctcac cttcaatggt ttgccatgtt ttctcctatt 9600gtgccttttt ggataacagc aatctatgta ttctgtattt ctctgaagca ctgccattgg 9660ttctttaaca actatcttag gaaaagagtc atgtttaatg gagttacatt tagtaccttc 9720gaggaggctg ctttgtgtac ctttttgctc aacaaggaaa tgtacctaaa attgcgtagc 9780gagacactgt tgccacttac acagtataac aggtatcttg ctctatataa caagtacaag 9840tatttcagtg gagccttaga tactaccagc tatcgtgaag cagcttgctg ccacttagca 9900
aaggctctaa atgactttag caactcaggt gctgatgttc tctaccaacc accacagaca 9960tcaatcactt ctgctgttct gcagagtggt tttaggaaaa tggcattccc gtcaggcaaa 10020gttgaagggt gcatggtaca agtaacctgt ggaactacaa ctcttaatgg attgtggttg 10080gatgacacag tatactgtcc aagacatgtc atttgcacag cagaagacat gcttaatcct 10140aactatgaag atctgctcat tcgcaaatcc aaccatagct ttcttgttca ggctggcaat 10200gttcaacttc gtgttattgg ccattctatg caaaattgtc tgcttaggct taaagttgat 10260acttctaacc ctaagacacc caagtataaa tttgtccgta tccaacctgg tcaaacattt 10320tcagttctag catgctacaa tggttcacca tctggtgttt atcagtgtgc catgagacct 10380aatcatacca ttaaaggttc tttccttaat ggatcatgtg gtagtgttgg ttttaacatt 10440gattatgatt gcgtgtcttt ctgctatatg catcatatgg agcttccaac aggagtacac 10500gctggtactg acttagaagg taaattctat ggtccatttg ttgacagaca aactgcacag 10560gctgcaggta cagacacaac cataacatta aatgttttgg catggctgta tgctgctgtt 10620atcaatggtg ataggtggtt tcttaataga ttcaccacta ctttgaatga ctttaacctt 10680gtggcaatga agtacaacta tgaacctttg acacaagatc atgttgacat attgggacct 10740ctttctgctc aaacaggaat tgccgtctta gatatgtgtg ctgctttgaa agagctgctg 10800cagaatggta tgaatggtcg tactatcctt ggtagcacta ttttagaaga tgagtttaca 10860ccatttgatg ttgttagaca atgctctggt gttaccttcc aaggtaagtt caagaaaatt 10920gttaagggca ctcatcattg gatgctttta actttcttga catcactatt gattcttgtt 10980caaagtacac agtggtcact gtttttcttt gtttacgaga atgctttctt gccatttact 11040cttggtatta tggcaattgc tgcatgtgct atgctgcttg ttaagcataa gcacgcattc 11100ttgtgcttgt ttctgttacc ttctcttgca acagttgctt actttaatat ggtctacatg 11160cctgctagct gggtgatgcg tatcatgaca tggcttgaat tggctgacac tagcttgtct 11220
ggttataggc ttaaggattg tgttatgtat gcttcagctt tagttttgct tattctcatg 11280acagctcgca ctgtttatga tgatgctgct agacgtgttt ggacactgat gaatgtcatt 11340acacttgttt acaaagtcta ctatggtaat gctttagatc aagctatttc catgtgggcc 11400ttagttattt ctgtaacctc taactattct ggtgtcgtta cgactatcat gtttttagct 11460agagctatag tgtttgtgtg tgttgagtat tacccattgt tatttattac tggcaacacc 11520ttacagtgta tcatgcttgt ttattgtttc ttaggctatt gttgctgctg ctactttggc 11580cttttctgtt tactcaaccg ttacttcagg cttactcttg gtgtttatga ctacttggtc 11640tctacacaag aatttaggta tatgaactcc caggggcttt tgcctcctaa gagtagtatt 11700gatgctttca agcttaacat taagttgttg ggtattggag gtaaaccatg tatcaaggtt 11760gctactgtac agtctaaaat gtctgacgta aagtgcacat ctgtggtact gctctcggtt 11820cttcaacaac ttagagtaga gtcatcttct aaattgtggg cacaatgtgt acaactccac 11880aatgatattc ttcttgcaaa agacacaact gaagctttcg agaagatggt ttctcttttg 11940tctgttttgc tatccatgca gggtgctgta gacattaata ggttgtgcga ggaaatgctc 12000gataaccgtg ctactcttca ggctattgct tcagaattta gttctttacc atcatatgcc 12060gcttatgcca ctgcccagga ggcctatgag caggctgtag ctaatggtga ttctgaagtc 12120gttctcaaaa agttaaagaa atctttgaat gtggctaaat ctgagtttga ccgtgatgct 12180gccatgcaac gcaagttgga aaagatggca gatcaggcta tgacccaaat gtacaaacag 12240gcaagatctg aggacaagag ggcaaaagta actagtgcta tgcaaacaat gctcttcact 12300atgcttagga agcttgataa tgatgcactt aacaacatta tcaacaatgc gcgtgatggt 12360tgtgttccac tcaacatcat accattgact acagcagcca aactcatggt tgttgtccct 12420gattatggta cctacaagaa cacttgtgat ggtaacacct ttacatatgc atctgcactc 12480tgggaaatcc agcaagttgt tgatgcggat agcaagattg ttcaacttag tgaaattaac 12540
atggacaatt caccaaattt ggcttggcct cttattgtta cagctctaag agccaactca 12600gctgttaaac tacagaataa tgaactgagt ccagtagcac tacgacagat gtcctgtgcg 12660gctggtacca cacaaacagc ttgtactgat gacaatgcac ttgcctacta taacaattcg 12720aagggaggta ggtttgtgct ggcattacta tcagaccacc aagatctcaa atgggctaga 12780ttccctaaga gtgatggtac aggtacaatt tacacagaac tggaaccacc ttgtaggttt 12840gttacagaca caccaaaagg gcctaaagtg aaatacttgt acttcatcaa aggcttaaac 12900aacctaaata gaggtatggt gctgggcagt ttagctgcta cagtacgtct tcaggctgga 12960aatgctacag aagtacctgc caattcaact gtgctttcct tctgtgcttt tgcagtagac 13020cctgctaaag catataagga ttacctagca agtggaggac aaccaatcac caactgtgtg 13080aagatgttgt gtacacacac tggtacagga caggcaatta ctgtaacacc agaagctaac 13140atggaccaag agtcctttgg tggtgcttca tgttgtctgt attgtagatg ccacattgac 13200catccaaatc ctaaaggatt ctgtgacttg aaaggtaagt acgtccaaat acctaccact 13260tgtgctaatg acccagtggg ttttacactt agaaacacag tctgtaccgt ctgcggaatg 13320tggaaaggtt atggctgtag ttgtgaccaa ctccgcgaac ccttgatgca gtctgcggat 13380gcatcaacgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca ccgtgcggca 13440caggcactag tactgatgtc gtctacaggg cttttgatat ttacaacgaa aaagttgctg 13500gttttgcaaa gttcctaaaa actaattgct gtcgcttcca ggagaaggat gaggaaggca 13560atttattaga ctcttacttt gtagttaaga ggcatactat gtctaactac caacatgaag 13620agactattta taacttggtt aaagattgtc cagcggttgc tgtccatgac tttttcaagt 13680ttagagtaga tggtgacatg gtaccacata tatcacgtca gcgtctaact aaatacacaa 13740tggctgattt agtctatgct ctacgtcatt ttgatgaggg taattgtgat acattaaaag 13800aaatactcgt cacatacaat tgctgtgatg atgattattt caataagaag gattggtatg 13860acttcgtaga gaatcctgac atcttacgcg tatatgctaa cttaggtgag cgtgtacgcc 13920
aatcattatt aaagactgta caattctgcg atgctatgcg tgatgcaggc attgtaggcg 13980tactgacatt agataatcag gatcttaatg ggaactggta cgatttcggt gatttcgtac 14040aagtagcacc aggctgcgga gttcctattg tggattcata ttactcattg ctgatgccca 14100tcctcacttt gactagggca ttggctgctg agtcccatat ggatgctgat ctcgcaaaac 14160cacttattaa gtgggatttg ctgaaatatg attttacgga agagagactt tgtctcttcg 14220accgttattt taaatattgg gaccagacat accatcccaa ttgtattaac tgtttggatg 14280ataggtgtat ccttcattgt gcaaacttta atgtgttatt ttctactgtg tttccaccta 14340caagttttgg accactagta agaaaaatat ttgtagatgg tgttcctttt gttgtttcaa 14400ctggatacca ttttcgtgag ttaggagtcg tacataatca ggatgtaaac ttacatagct 14460cgcgtctcag tttcaaggaa cttttagtgt atgctgctga tccagctatg catgcagctt 14520ctggcaattt attgctagat aaacgcacta catgcttttc agtagctgca ctaacaaaca 14580atgttgcttt tcaaactgtc aaacccggta attttaataa agacttttat gactttgctg 14640tgtctaaagg tttctttaag gaaggaagtt ctgttgaact aaaacacttc ttctttgctc 14700aggatggcaa cgctgctatc agtgattatg actattatcg ttataatctg ccaacaatgt 14760gtgatatcag acaactccta ttcgtagttg aagttgttga taaatacttt gattgttacg 14820atggtggctg tattaatgcc aaccaagtaa tcgttaacaa tctggataaa tcagctggtt 14880tcccatttaa taaatggggt aaggctagac tttattatga ctcaatgagt tatgaggatc 14940aagatgcact tttcgcgtat actaagcgta atgtcatccc tactataact caaatgaatc 15000ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc tctatctgta 15060gtactatgac aaatagacag tttcatcaga aattattgaa gtcaatagcc gccactagag 15120gagctactgt ggtaattgga acaagcaagt tttacggtgg ctggcataat atgttaaaaa 15180ctgtttacag tgatgtagaa actccacacc ttatgggttg ggattatcca aaatgtgaca 15240
gagccatgcc taacatgctt aggataatgg cctctcttgt tcttgctcgc aaacataaca 15300cttgctgtaa cttatcacac cgtttctaca ggttagctaa cgagtgtgcg caagtattaa 15360gtgagatggt catgtgtggc ggctcactat atgttaaacc aggtggaaca tcatccggtg 15420atgctacaac tgcttatgct aatagtgtct ttaacatttg tcaagctgtt acagccaatg 15480taaatgcact tctttcaact gatggtaata agatagctga caagtatgtc cgcaatctac 15540aacacaggct ctatgagtgt ctctatagaa atagggatgt tgatcatgaa ttcgtggatg 15600agttttacgc ttacctgcgt aaacatttct ccatgatgat tctttctgat gatgccgttg 15660tgtgctataa cagtaactat gcggctcaag gtttagtagc tagcattaag aactttaagg 15720cagttcttta ttatcaaaat aatgtgttca tgtctgaggc aaaatgttgg actgagactg 15780accttactaa aggacctcac gaattttgct cacagcatac aatgctagtt aaacaaggag 15840atgattacgt gtacctgcct tacccagatc catcaagaat attaggcgca ggctgttttg 15900tcgatgatat tgtcaaaaca gatggtacac ttatgattga aaggttcgtg tcactggcta 15960ttgatgctta cccacttaca aaacatccta atcaggagta tgctgatgtc tttcacttgt 16020atttacaata cattagaaag ttacatgatg agcttactgg ccacatgttg gacatgtatt 16080ccgtaatgct aactaatgat aacacctcac ggtactggga acctgagttt tatgaggcta 16140tgtacacacc acatacagtc ttgcaggctg taggtgcttg tgtattgtgc aattcacaga 16200cttcacttcg ttgcggtgcc tgtattagga gaccattcct atgttgcaag tgctgctatg 16260accatgtcat ttcaacatca cacaaattag tgttgtctgt taatccctat gtttgcaatg 16320ccccaggttg tgatgtcact gatgtgacac aactgtatct aggaggtatg agctattatt 16380gcaagtcaca taagcctccc attagttttc cattatgtgc taatggtcag gtttttggtt 16440tatacaaaaa cacatgtgta ggcagtgaca atgtcactga cttcaatgcg atagcaacat 16500gtgattggac taatgctggc gattacatac ttgccaacac ttgtactgag agactcaagc 16560
ttttcgcagc agaaacgctc aaagccactg aggaaacatt taagctgtca tatggtattg 16620ccactgtacg cgaagtactc tctgacagag aattgcatct ttcatgggag gttggaaaac 16680ctagaccacc attgaacaga aactatgtct ttactggtta ccgtgtaact aaaaatagta 16740aagtacagat tggagagtac acctttgaaa aaggtgacta tggtgatgct gttgtgtaca 16800gaggtactac gacatacaag ttgaatgttg gtgattactt tgtgttgaca tctcacactg 16860taatgccact tagtgcacct actctagtgc cacaagagca ctatgtgaga attactggct 16920tgtacccaac actcaacatc tcagatgagt tttctagcaa tgttgcaaat tatcaaaagg 16980tcggcatgca aaagtactct acactccaag gaccacctgg tactggtaag agtcattttg 17040ccatcggact tgctctctat tacccatctg ctcgcatagt gtatacggca tgctctcatg 17100cagctgttga tgccctatgt gaaaaggcat taaaatattt gcccatagat aaatgtagta 17160gaatcatacc tgcgcgtgcg cgcgtagagt gttttgataa attcaaagtg aattcaacac 17220tagaacagta tgttttctgc actgtaaatg cattgccaga aacaactgct gacattgtag 17280tctttgatga aatctctatg gctactaatt atgacttgag tgttgtcaat gctagacttc 17340gtgcaaaaca ctacgtctat attggcgatc ctgctcaatt accagccccc cgcacattgc 17400tgactaaagg cacactagaa ccagaatatt ttaattcagt gtgcagactt atgaaaacaa 17460taggtccaga catgttcctt ggaacttgtc gccgttgtcc tgctgaaatt gttgacactg 17520tgagtgcttt agtttatgac aataagctaa aagcacacaa ggataagtca gctcaatgct 17580tcaaaatgtt ctacaaaggt gttattacac atgatgtttc atctgcaatc aacagacctc 17640aaataggcgt tgtaagagaa tttcttacac gcaatcctgc ttggagaaaa gctgttttta 17700tctcacctta taattcacag aacgctgtag cttcaaaaat cttaggattg cctacgcaga 17760ctgttgattc atcacagggt tctgaatatg actatgtcat attcacacaa actactgaaa 17820cagcacactc ttgtaatgtc aaccgcttca atgtggctat cacaagggca aaaattggca 17880
ttttgtgcat aatgtctgat agagatcttt atgacaaact gcaatttaca agtctagaaa 17940taccacgtcg caatgtggct acattacaag cagaaaatgt aactggactt tttaaggact 18000gtagtaagat cattactggt cttcatccta cacaggcacc tacacacctc agcgttgata 18060taaagttcaa gactgaagga ttatgtgttg acataccagg cataccaaag gacatgacct 18120accgtagact catctctatg atgggtttca aaatgaatta ccaagtcaat ggttacccta 18180atatgtttat cacccgcgaa gaagctattc gtcacgttcg tgcgtggatt ggctttgatg 18240tagagggctg tcatgcaact agagatgctg tgggtactaa cctacctctc cagctaggat 18300tttctacagg tgttaactta gtagctgtac cgactggtta tgttgacact gaaaataaca 18360cagaattcac cagagttaat gcaaaacctc caccaggtga ccagtttaaa catcttatac 18420cactcatgta taaaggcttg ccctggaatg tagtgcgtat taagatagta caaatgctca 18480gtgatacact gaaaggattg tcagacagag tcgtgttcgt cctttgggcg catggctttg 18540agcttacatc aatgaagtac tttgtcaaga ttggacctga aagaacgtgt tgtctgtgtg 18600acaaacgtgc aacttgcttt tctacttcat cagatactta tgcctgctgg aatcattctg 18660tgggttttga ctatgtctat aacccattta tgattgatgt tcagcagtgg ggctttacgg 18720gtaaccttca gagtaaccat gaccaacatt gccaggtaca tggaaatgca catgtggcta 18780gttgtgatgc tatcatgact agatgtttag cagtccatga gtgctttgtt aagcgcgttg 18840attggtctgt tgaataccct attataggag atgaactgag ggttaattct gcttgcagaa 18900aagtacaaca catggttgtg aagtctgcat tgcttgctga taagtttcca gttcttcatg 18960acattggaaa tccaaaggct atcaagtgtg tgcctcaggc tgaagtagaa tggaagttct 19020acgatgctca gccatgtagt gacaaagctt acaaaataga ggaactcttc tattcttatg 19080ctacacatca cgataaattc actgatggtg tttgtttgtt ttggaattgt aacgttgatc 19140gttacccagc caatgcaatt gtgtgtaggt ttgacacaag agtcttgtca aacttgaact 19200
taccaggctg tgatggtggt agtttgtatg tgaataagca tgcattccac actccagctt 19260tcgataaaag tgcatttact aatttaaagc aattgccttt cttttactat tctgatagtc 19320cttgtgagtc tcatggcaaa caagtagtgt cggatattga ttatgttcca ctcaaatctg 19380ctacgtgtat tacacgatgc aatttaggtg gtgctgtttg cagacaccat gcaaatgagt 19440accgacagta cttggatgca tataatatga tgatttctgc tggatttagc ctatggattt 19500acaaacaatt tgatacttat aacctgtgga atacatttac caggttacag agtttagaaa 19560atgtggctta taatgttgtt aataaaggac actttgatgg acacgccggc gaagcacctg 19620tttccatcat taataatgct gtttacacaa aggtagatgg tattgatgtg gagatctttg 19680aaaataagac aacacttcct gttaatgttg catttgagct ttgggctaag cgtaacatta 19740aaccagtgcc agagattaag atactcaata atttgggtgt tgatatcgct gctaatactg 19800taatctggga ctacaaaaga gaagccccag cacatgtatc tacaataggt gtctgcacaa 19860tgactgacat tgccaagaaa cctactgaga gtgcttgttc ttcacttact gtcttgtttg 19920atggtagagt ggaaggacag gtagaccttt ttagaaacgc ccgtaatggt gttttaataa 19980cagaaggttc agtcaaaggt ctaacacctt caaagggacc agcacaagct agcgtcaatg 20040gagtcacatt aattggagaa tcagtaaaaa cacagtttaa ctactttaag aaagtagacg 20100gcattattca acagttgcct gaaacctact ttactcagag cagagactta gaggatttta 20160agcccagatc acaaatggaa actgactttc tcgagctcgc tatggatgaa ttcatacagc 20220gatataagct cgagggctat gccttcgaac acatcgttta tggagatttc agtcatggac 20280aacttggcgg tcttcattta atgataggct tagccaagcg ctcacaagat tcaccactta 20340aattagagga ttttatccct atggacagca cagtgaaaaa ttacttcata acagatgcgc 20400aaacaggttc atcaaaatgt gtgtgttctg tgattgatct tttacttgat gactttgtcg 20460agataataaa gtcacaagat ttgtcagtga tttcaaaagt ggtcaaggtt acaattgact 20520
atgctgaaat ttcattcatg ctttggtgta aggatggaca tgttgaaacc ttctacccaa 20580aactacaagc aagtcaagcg tggcaaccag gtgttgcgat gcctaacttg tacaagatgc 20640aaagaatgct tcttgaaaag tgtgaccttc agaattatgg tgaaaatgct gttataccaa 20700aaggaataat gatgaatgtc gcaaagtata ctcaactgtg tcaatactta aatacactta 20760ctttagctgt accctacaac atgagagtta ttcactttgg tgctggctct gataaaggag 20820ttgcaccagg tacagctgtg ctcagacaat ggttgccaac tggcacacta cttgtcgatt 20880cagatcttaa tgacttcgtc tccgacgcag attctacttt aattggagac tgtgcaacag 20940tacatacggc taataaatgg gaccttatta ttagcgatat gtatgaccct aggaccaaac 21000atgtgacaaa agagaatgac tctaaagaag ggtttttcac ttatctgtgt ggatttataa 21060agcaaaaact agccctgggt ggttctatag ctgtaaagat aacagagcat tcttggaatg 21120ctgaccttta caagcttatg ggccatttct catggtggac agcttttgtt acaaatgtaa 21180atgcatcatc atcggaagca tttttaattg gggctaacta tcttggcaag ccgaaggaac 21240aaattgatgg ctataccatg catgctaact acattttctg gaggaacaca aatcctatcc 21300agttgtcttc ctattcactc tttgacatga gcaaatttcc tcttaaatta agaggaactg 21360ctgtaatgtc tcttaaggag aatcaaatca atgatatgat ttattctctt ctggaaaaag 21420gtaggcttat cattagagaa aacaacagag ttgtggtttc aagtgatatt cttgttaaca 21480actaaacgaa catgtttatt ttcttattat ttcttactct cactagtggt agtgaccttg 21540accggtgcac cacttttgat gatgttcaag ctcctaatta cactcaacat acttcatcta 21600tgaggggggt ttactatcct gatgaaattt ttagatcaga cactctttat ttaactcagg 21660atttatttct tccattttat tctaatgtta cagggtttca tactattaat catacgtttg 21720gcaaccctgt catacctttt aaggatggta tttattttgc tgccacagag aaatcaaatg 21780ttgtccgtgg ttgggttttt ggttctacca tgaacaacaa gtcacagtcg gtgattatta 21840
ttaacaattc tactaatgtt gttatacgag catgtaactt tgaattgtgt gacaaccctt 21900tctttgctgt ttctaaaccc atgggtacac agacacatac tatgatattc gataatgcat 21960ttaattgcac tttcgagtac atatctgatg ccttttcgct tgatgtttca gaaaagtcag 22020gtaattttaa acacttacga gagtttgtgt ttaaaaataa agatgggttt ctctatgttt 22080ataagggcta tcaacctata gatgtagttc gtgatctacc ttctggtttt aacactttga 22140aacctatttt taagttgcct cttggtatta acattacaaa ttttagagcc attcttacag 22200ccttttcacc tgctcaagac atttggggca cgtcagctgc agcctatttt gttggctatt 22260taaagccaac tacatttatg ctcaagtatg atgaaaatgg tacaatcaca gatgctgttg 22320attgttctca aaatccactt gctgaactca aatgctctgt taagagcttt gagattgaca 22380aaggaattta ccagacctct aatttcaggg ttgttccctc aggagatgtt gtgagattcc 22440ctaatattac aaacttgtgt ccttttggag aggtttttaa tgctactaaa ttcccttctg 22500tctatgcatg ggagagaaaa aaaatttcta attgtgttgc tgattactct gtgctctaca 22560actcaacatt tttttcaacc tttaagtgct atggcgtttc tgccactaag ttgaatgatc 22620tttgcttctc caatgtctat gcagattctt ttgtagtcaa gggagatgat gtaagacaaa 22680tagcgccagg acaaactggt gttattgctg attataatta taaattgcca gatgatttca 22740tgggttgtgt ccttgcttgg aatactagga acattgatgc tacttcaact ggtaattata 22800attataaata taggtatctt agacatggca agcttaggcc ctttgagaga gacatatcta 22860atgtgccttt ctcccctgat ggcaaacctt gcaccccacc tgctcttaat tgttattggc 22920cattaaatga ttatggtttt tacaccacta ctggcattgg ctaccaacct tacagagttg 22980tagtactttc ttttgaactt ttaaatgcac cggccacggt ttgtggacca aaattatcca 23040ctgaccttat taagaaccag tgtgtcaatt ttaattttaa tggactcact ggtactggtg 23100tgttaactcc ttcttcaaag agatttcaac catttcaaca atttggccgt gatgtttctg 23160
atttcactga ttccgttcga gatcctaaaa catctgaaat attagacatt tcaccttgct 23220cttttggggg tgtaagtgta attacacctg gaacaaatgc ttcatctgaa gttgctgttc 23280tatatcaaga tgttaactgc actgatgttt ctacagcaat tcatgcagat caactcacac 23340cagcttggcg catatattct actggaaaca atgtattcca gactcaagca ggctgtctta 23400taggagctga gcatgtcgac acttcttatg agtgcgacat tcctattgga gctggcattt 23460gtgctagtta ccatacagtt tctttattac gtagtactag ccaaaaatct attgtggctt 23520atactatgtc tttaggtgct gatagttcaa ttgcttactc taataacacc attgctatac 23580ctactaactt ttcaattagc attactacag aagtaatgcc tgtttctatg gctaaaacct 23640ccgtagattg taatatgtac atctgcggag attctactga atgtgctaat ttgcttctcc 23700aatatggtag cttttgcaca caactaaatc gtgcactctc aggtattgct gctgaacagg 23760atcgcaacac acgtgaagtg ttcgctcaag tcaaacaaat gtacaaaacc ccaactttga 23820aatattttgg tggttttaat ttttcacaaa tattacctga ccctctaaag ccaactaaga 23880ggtcttttat tgaggacttg ctctttaata aggtgacact cgctgatgct ggcttcatga 23940agcaatatgg cgaatgccta ggtgatatta atgctagaga tctcatttgt gcgcagaagt 24000tcaatggact tacagtgttg ccacctctgc tcactgatga tatgattgct gcctacactg 24060ctgctctagt tagtggtact gccactgctg gatggacatt tggtgctggc gctgctcttc 24120aaataccttt tgctatgcaa atggcatata ggttcaatgg cattggagtt acccaaaatg 24180ttctctatga gaaccaaaaa caaatcgcca accaatttaa caaggcgatt agtcaaattc 24240aagaatcact tacaacaaca tcaactgcat tgggcaagct gcaagacgtt gttaaccaga 24300atgctcaagc attaaacaca cttgttaaac aacttagctc taattttggt gcaatttcaa 24360gtgtgctaaa tgatatcctt tcgcgacttg ataaagtcga ggcggaggta caaattgaca 24420ggttaattac aggcagactt caaagccttc aaacctatgt aacacaacaa ctaatcaggg 24480
ctgctgaaat cagggcttct gctaatcttg ctgctactaa aatgtctgag tgtgttcttg 24540gacaatcaaa aagagttgac ttttgtggaa agggctacca ccttatgtcc ttcccacaag 24600cagccccgca tggtgttgtc ttcctacatg tcacgtatgt gccatcccag gagaggaact 24660tcaccacagc gccagcaatt tgtcatgaag gcaaagcata cttccctcgt gaaggtgttt 24720ttgtgtttaa tggcacttct tggtttatta cacagaggaa cttcttttct ccacaaataa 24780ttactacaga caatacattt gtctcaggaa attgtgatgt cgttattggc atcattaaca 24840acacagttta tgatcctctg caacctgagc ttgactcatt caaagaagag ctggacaagt 24900acttcaaaaa tcatacatca ccagatgttg atcttggcga catttcaggc attaacgctt 24960ctgtcgtcaa cattcaaaaa gaaattgacc gcctcaatga ggtcgctaaa aatttaaatg 25020aatcactcat tgaccttcaa gaattgggaa aatatgagca atatattaaa tggccttggt 25080atgtttggct cggcttcatt gctggactaa ttgccatcgt catggttaca atcttgcttt 25140gttgcatgac tagttgttgc agttgcctca agggtgcatg ctcttgtggt tcttgctgca 25200agtttgatga ggatgactct gagccagttc tcaagggtgt caaattacat tacacataaa 25260cgaacttatg gatttgttta tgagattttt tactcttgga tcaattactg cacagccagt 25320aaaaattgac aatgcttctc ctgcaagtac tgttcatgct acagcaacga taccgctaca 25380agcctcactc cctttcggat ggcttgttat tggcgttgca tttcttgctg tttttcagag 25440cgctaccaaa ataattgcgc tcaataaaag atggcagcta gccctttata agggcttcca 25500gttcatttgc aatttactgc tgctatttgt taccatctat tcacatcttt tgcttgtcgc 25560tgcaggtatg gaggcgcaat ttttgtacct ctatgccttg atatattttc tacaatgcat 25620caacgcatgt agaattatta tgagatgttg gctttgttgg aagtgcaaat ccaagaaccc 25680attactttat gatgccaact actttgtttg ctggcacaca cataactatg actactgtat 25740accatataac agtgtcacag atacaattgt cgttactgaa ggtgacggca tttcaacacc 25800
aaaactcaaa gaagactacc aaattggtgg ttattctgag gataggcact caggtgttaa 25860agactatgtc gttgtacatg gctatttcac cgaagtttac taccagcttg agtctacaca 25920aattactaca gacactggta ttgaaaatgc tacattcttc atctttaaca agcttgttaa 25980agacccaccg aatgtgcaaa tacacacaat cgacggctct tcaggagttg ctaatccagc 26040aatggatcca atttatgatg agccgacgac gactactagc gtgcctttgt aagcacaaga 26100aagtgagtac gaacttatgt actcattcgt ttcggaagaa acaggtacgt taatagttaa 26160tagcgtactt ctttttcttg ctttcgtggt attcttgcta gtcacactag ccatccttac 26220tgcgcttcga ttgtgtgcgt actgctgcaa tattgttaac gtgagtttag taaaaccaac 26280ggtttacgtc tactcgcgtg ttaaaaatct gaactcttct gaaggagttc ctgatcttct 26340ggtctaaacg aactaactat tattattatt ctgtttggaa ctttaacatt gcttatcatg 26400gcagacaacg gtactattac cgttgaggag cttaaacaac tcctggaaca atggaaccta 26460gtaataggtt tcctattcct agcctggatt atgttactac aatttgccta ttctaatcgg 26520aacaggtttt tgtacataat aaagcttgtt ttcctctggc tcttgtggcc agtaacactt 26580gcttgttttg tgcttgctgc tgtctacaga attaattggg tgactggcgg gattgcgatt 26640gcaatggctt gtattgtagg cttgatgtgg cttagctact tcgttgcttc cttcaggctg 26700tttgctcgta cccgctcaat gtggtcattc aacccagaaa caaacattct tctcaatgtg 26760cctctccggg ggacaattgt gaccagaccg ctcatggaaa gtgaacttgt cattggtgct 26820gtgatcattc gtggtcactt gcgaatggcc ggacactccc tagggcgctg tgacattaag 26880gacctgccaa aagagatcac tgtggctaca tcacgaacgc tttcttatta caaattagga 26940gcgtcgcagc gtgtaggcac tgattcaggt tttgctgcat acaaccgcta ccgtattgga 27000aactataaat taaatacaga ccacgccggt agcaacgaca atattgcttt gctagtacag 27060taagtgacaa cagatgtttc atcttgttga cttccaggtt acaatagcag agatattgat 27120
tatcattatg aggactttca ggattgctat ttggaatctt gacgttataa taagttcaat 27180agtgagacaa ttatttaagc ctctaactaa gaagaattat tcggagttag atgatgaaga 27240acctatggag ttagattatc cataaaacga acatgaaaat tattctcttc ctgacattga 27300ttgtatttac atcttgcgag ctatatcact atcaggagtg tgttagaggt acgactgtac 27360tactaaaaga accttgccca tcaggaacat acgagggcaa ttcaccattt caccctcttg 27420ctgacaataa atttgcacta acttgcacta gcacacactt tgcttttgct tgtgctgacg 27480gtactcgaca tacctatcag ctgcgtgcaa gatcagtttc accaaaactt ttcatcagac 27540aagaggaggt tcaacaagag ctctactcgc cactttttct cattgttgct gctctagtat 27600ttttaatact ttgcttcacc attaagagaa agacagaatg aatgagctca ctttaattga 27660cttctatttg tgctttttag cctttctgct attccttgtt ttaataatgc ttattatatt 27720ttggttttca ctcgaaatcc aggatctaga agaaccttgt accaaagtct aaacgaacat 27780gaaacttctc attgttttga cttgtatttc tctatgcagt tgcatatgca ctgtagtaca 27840gcgctgtgca tctaataaac ctcatgtgct tgaagatcct tgtaaggtac aacactaggg 27900gtaatactta tagcactgct tggctttgtg ctctaggaaa ggttttacct tttcatagat 27960ggcacactat ggttcaaaca tgcacaccta atgttactat caactgtcaa gatccagctg 28020gtggtgcgct tatagctagg tgttggtacc ttcatgaagg tcaccaaact gctgcattta 28080gagacgtact tgttgtttta aataaacgaa caaattaaaa tgtctgataa tggaccccaa 28140tcaaaccaac gtagtgcccc ccgcattaca tttggtggac ccacagattc aactgacaat 28200aaccagaatg gaggacgcaa tggggcaagg ccaaaacagc gccgacccca aggtttaccc 28260aataatactg cgtcttggtt cacagctctc actcagcatg gcaaggagga acttagattc 28320cctcgaggcc agggcgttcc aatcaacacc aatagtggtc cagatgacca aattggctac 28380taccgaagag ctacccgacg agttcgtggt ggtgacggca aaatgaaaga gctcagcccc 28440
agatggtact tctattacct aggaactggc ccagaagctt cacttcccta cggcgctaac 28500aaagaaggca tcgtatgggt tgcaactgag ggagccttga atacacccaa agaccacatt 28560ggcacccgca atcctaataa caatgctgcc accgtgctac aacttcctca aggaacaaca 28620ttgccaaaag gcttctacgc agagggaagc agaggcggca gtcaagcctc ttctcgctcc 28680tcatcacgta gtcgcggtaa ttcaagaaat tcaactcctg gcagcagtag gggaaattct 28740cctgctcgaa tggctagcgg aggtggtgaa actgccctcg cgctattgct gctagacaga 28800ttgaaccagc ttgagagcaa agtttctggt aaaggccaac aacaacaagg ccaaactgtc 28860actaagaaat ctgctgctga ggcatctaaa aagcctcgcc aaaaacgtac tgccacaaaa 28920cagtacaacg tcactcaagc atttgggaga cgtggtccag aacaaaccca aggaaatttc 28980ggggaccaag acctaatcag acaaggaact gattacaaac attggccgca aattgcacaa 29040tttgctccaa gtgcctctgc attctttgga atgtcacgca ttggcatgga agtcacacct 29100tcgggaacat ggctgactta tcatggagcc attaaattgg atgacaaaga tccacaattc 29160aaagacaacg tcatactgct gaacaagcac attgacgcat acaaaacatt cccaccaaca 29220gagcctaaaa aggacaaaaa gaaaaagact gatgaagctc agcctttgcc gcagagacaa 29280aagaagcagc ccactgtgac tcttcttcct gcggctgaca tggatgattt ctccagacaa 29340cttcaaaatt ccatgagtgg agcttctgct gattcaactc aggcataaac actcatgatg 29400accacacaag gcagatgggc tatgtaaacg ttt tcgcaat tccgtttacg atacatagtc 29460tactcttgtg cagaatgaat tctcgtaact aaacagcaca agtaggttta gttaacttta 29520atctcacata gcaatcttta atcaatgtgt aacattaggg aggacttgaa agagccacca 29580cattttcatc gaggccacgc ggagtacgat cgagggtaca gtgaataatg ctagggagag 29640ctgcctatat ggaagagccc taatgtgtaa aattaatttt agtagtgcta tccccatgtg 29700attttaatag cttcttagga gaatgacaaa aaaaaaaaaa aaaa
<110>杭州新瑞佳生物医药技术开发有限公司<120>针对SARS病毒的SiRNA分子<160>129<210>2<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>2uggaagcgac agcaauuagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>3<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>3cuccuggaag cgacagcaat t 21<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>4<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>4uaaauugccu uccucaucct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>5<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>5guuagacaua guaugccuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129<210>6<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>6agucucuuca uguugguagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>7<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>7cagcaaccgc uggacaauct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129
<210>8<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>8gucaccaucu acucuaaact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>9<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>9gcauagacua aaucagccat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>10
<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>10gaagucauac caauccuuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>11<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>11uacgaaguca uaccaaucct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>12<211>21<212>RNA
<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>12uacgcguaag augucaggat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>13<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>13gcguacacgc ucaccuaagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>14<211>21<212>RNA<213>人工序列
<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>14aucgcagaau uguacaguct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>15<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>15cacgcauagc aucgcagaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>16<211>21<212>RNA<213>人工序列<220>
<221>misc_feature
<222>1...21<223>双链，表中所列为反义链序列<400>16aucaccgaaa ucguaccagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>17<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>17cgaagagaca aagucucuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>18<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列
<400>18acaccuauca uccaaacagt t 2114002…14023<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>19<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>19gagacgcgag cuauguaagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>20<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>20
uucaacagaa cuuccuucct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>21<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>21ccugagcaaa gaagaagugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>22<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>22auaaucacug auagcagcgt t 21
<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>23<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>23aucacacauu guuggcagat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>24<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>24cuucaacuac gaauaggagt t 21<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>25<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>25aacgauuacu ugguuggcat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>26<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>26accagcugau uuauccagat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>27<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>27cuuugcacua auggcauact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>28<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>28uacggugcga gcucuauuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129<210>29<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>29agcuacggug cgagcucuat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>30<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>30ucuaguggcg gcuauugact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129
<210>31<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>31uaggcauggc ucugucacat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>32<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>32ggccauuauc cuaagcaugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>33<211>21
<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>33gcaagaacaa gagaggccat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>34<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>34guagaaacgg ugugauaagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>35<211>21<212>RNA<213>人工序列
<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>35uaauacuugc gcacacucgt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>36<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>36ccacacauga ccaucucact t 2115093…15114<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>37<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>37cggaugaugu uccaccuggt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>38<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>38guagcaucac cggaugaugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>39<211>21<212>RNA<213>人工序列<220>
<22 1>misc_feature<222>1...21
<223>双链，表中所列为反义链序列<400>39uuacauuggc uguaacagct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>40<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>40gacauacuug ucagcuauct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>41<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列
<400>41uuguagauug cggacauact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>42<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>42auagagccug uguuguagat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>43<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>43
gacacucaua gagccugugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>44<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>44uugagccgca uaguuacugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>45<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>45uaaaccuuga gccgcauagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>46<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>46ugccucagac augaacacat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>47<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>47ggucagucuc aguccaacat t 21<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>48<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>48acacguaauc aucuccuugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>49<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>49gguacacgua aucaucucct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129<210>50<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>50cagccugcgc cuaauauuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>51<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>51aaacagccug cgccuaauat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129
<210>52<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>52auagccagug acacgaacct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>53<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>53cauacuccug auuaggaugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>54
<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>54cgugaggugu uaucauuagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>55<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>55guaccgugag guguuaucat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>56<211>21<212>RNA
<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>56acgaagugaa gucugugaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>57<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>57gacaugguca uagcagcact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>58<211>21<212>RNA<213>人工序列
<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>58ucauaccucc uagauacagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>59<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>59guugagugua auuaggagct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>60<211>21<212>RNA<213>人工序列<220>
<221>misc_feature
<222>1...21<223>双链，表中所列为反义链序列<400>60aaccacggac aacauuugat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>61<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>61caccgacugu gacuuguugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>62<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列
<400>62aaucaccgac ugugacuugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>63<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>63aauaaucacc gacugugact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>64<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>64
acacaaacuc ucguaagugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>65<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>65cacgaacuac aucuauaggt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>66<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>66guuaauacca agaggcaact t 21
<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>67<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>67gagcauaaau guaguuggct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>68<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>68agcaucugug auuguaccat t 21<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>69<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>69caaucaacag caucugugat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>70<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>70uuugaguuca gcaaguggat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>71<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>71caaagcucuu aacagagcat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>72<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>72uagaggucug guaaauucct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129<210>73<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>73acgccauagc acuuaaaggt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>74<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>74ggcagaaacg ccauagcact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129
<210>75<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>75uguccuggcg cuauuuguct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>76<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>76ccaguuuguc cuggcgcuat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>77<211>21
<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>77ccaugaaauc aucuggcaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>78<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>78guacuacaac ucuguaaggt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>79<211>21<212>RNA<213>人工序列
<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>79accaguacca gugaguccat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>80<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>80ggccaaauug uugaaauggt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>81<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>81aaacaucacg gccaaauugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>82<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>82cagaaacauc acggccaaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>83<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21
<223>双链，表中所列为反义链序列<400>83guuccaggug uaauuacact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>84<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>84gcauuuguuc cagguguaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>85<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列
<400>85agcaacuuca gaugaagcat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>86<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>86caucagugca guuaacauct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>87<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>87
uguagaaaca ucagugcagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>88<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>88gugaguugau cugcaugaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>89<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>89cuccuauaag acagccugct t 21
<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>90<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>90aguagguaua gcaauggugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>91<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>91ccauagaaac aggcauuact t 21<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>92<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>92uuagccauag aaacaggcat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>93<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>93aucuccgcag auguacauat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129<210>94<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>94ggagaagcaa auuagcacat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>95<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>95cugagagugc acgauuuagt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129
<210>96<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>96aauaccugag agugcacgat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>97<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>97cacguguguu gcgauccugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129
<210>98<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>98agcgaacacu ucacgugugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>99<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>99guuugacuug agcgaacact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>100<211>21
<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>100aucagcgagu gucaccuuat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>101<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>101agcaucagcg agugucacct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>102<211>21<212>RNA<213>人工序列
<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>102uaggcauucg ccauauugct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>103<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>103caccuaggca uucgccauat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>104<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>104cacuguaagu ccauugaact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>105<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>105uggcaacacu guaaguccat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>106<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21
<223>双链，表中所列为反义链序列<400>106ccauugaacc uauaugccat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>107<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>107guuaacaacg ucuugcagct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>108<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列
<400>108cauucugguu aacaacguct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>109<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>109uaaugcuuga gcauucuggt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>110<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>110
aagucgcgaa aggauaucat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>111<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>111uuuguaccuc cgccucgact t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>112<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>112cuuugaaguc ugccuguaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>113<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>113guuacauagg uuugaaggct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>114<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>114ccaagaacac acucagacat t 21<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>115<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>115gcuuugccuu caugacaaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>116<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>116gccaauaacg acaucacaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129<210>117<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>117cagaggauca uaaacugugt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>118<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>118ugaaugaguc aagcucaggt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129
<210>119<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>119aguacuuguc cagcucuuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>120<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>120ugaaguacuu guccagcuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>121
<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>121aauguugacg acagaagcgt t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>122<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>122auugaggcgg ucaauuucut t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>123<211>21<212>RNA
<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>123cauugaggcg gucaauuuct t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>124<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>124accucauuga ggcggucaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>125<211>21<212>RNA<213>人工序列
<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>125cuugaagguc aaugagugat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>126<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>126gccaaacaua ccaaggccat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>127<211>21<212>RNA<213>人工序列<220>
<221>misc_feature
<222>1...21<223>双链，表中所列为反义链序列<400>127guaaccauga cgauggcaat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>128<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列<400>128gucaugcaac aaagcaagat t 21<110>杭州新瑞佳生物医药技术开发有限公司<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用<160>129<210>129<211>21<212>RNA<213>人工序列<220>
<221>misc_feature<222>1...21<223>双链，表中所列为反义链序列
<400>129agagucaucc ucaucaaact t 2权利要求
1.攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，它为双链RNA分子并且其核苷酸序列与具有以下特征的核苷酸序列(I)至少70％的同源度正义链和负义链的长度均为21个核苷酸，正义链和负义链各自的3’端为两个连续的脱氧胸苷酸(TT)，两条链除去3’端的TT以外的19个核苷酸上的碱基互补形成双链，正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致，每条链中的碱基为鸟嘌呤(G)的核苷酸及胞嘧啶(C)的核苷酸数量之和占除去3’端的TT以外的19个核苷酸数量的比例为大于30％小于70％(即G/C比例)，核苷酸序列(I)负链和其任意一个位置的核苷酸突变体和已知人类基因和基因表达片段无同源性。
2.权利要求1所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)还具有以下特征其正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域的连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致，其负义链相应配合。
3.权利要求2所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)还具有以下特征它的G/C比例为大于40％小于60％；它的正义链5’端是以碱基为鸟嘌呤(G)、胞嘧啶(C)、或尿嘧啶(U)的核苷酸中的一种开头，其负义链相应配合；其序列中不具有连续三个以上碱基为G或C的核苷酸也不具有连续四个以上碱基为A或U的核苷酸。
4.权利要求1所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)还具有以下特征其正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中的连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致，其负义链相应配合。
5.权利要求4所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)还具有以下特征它的G/C比例为大于40％小于60％；它的正义链5’端是以碱基为鸟嘌呤(G)、胞嘧啶(C)、或尿嘧啶(U)的核苷酸中的一种开头，其负义链相应配合；其序列中不具有连续三个以上碱基为G或C的核苷酸也不具有连续四个以上碱基为A或U的核苷酸。
6.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUAAUUGCUGUCGCUUCCATT，反义链UGGAAGCGACAGCAAUUAGTT。
7.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUGCUGUCGCUUCCAGGAGTT，反义链CUCCUGGAAGCGACAGCAATT。
8.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GGAUGAGGAAGGCAAUUUATT，反义链UAAAUUGCCUUCCUCAUCCTT。
9.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAGGCAUACUAUGUCUAACTT，反义链GUUAGACAUAGUAUGCCUCTT。
10.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUACCAACAUGAAGAGACUTT，反义链AGUCUCUUCAUGUUGGUAGTT。
11.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAUUGUCCAGCGGUUGCUGTT，反义链CAGCAACCGCUGGACAAUCTT。
12.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUUUAGAGUAGAUGGUGACTT，反义链GUCACCAUCUACUCUAAACTT。
13.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGGCUGAUUUAGUCUAUGCTT，反义链GCAUAGACUAAAUCAGCCATT。
14.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAAGGAUUGGUAUGACUUCTT，反义链GAAGUCAUACCAAUCCUUCTT。
15.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GGAUUGGUAUGACUUCGUATT，反义链UACGAAGUCAUACCAAUCCTT。
16.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCCUGACAUCUUACGCGUATT，反义链UACGCGUAAGAUGUCAGGATT。
17.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUUAGGUGAGCGUGUACGCTT，反义链GCGUACACGCUCACCUAAGTT。
18.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GACUGUACAAUUCUGCGAUTT，反义链AUCGCAGAAUUGUACAGUCTT。
19.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUCUGCGAUGCUAUGCGUGTT，反义链CACGCAUAGCAUCGCAGAATT。
20.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUGGUACGAUUUCGGUGAUTT，反义链AUCACCGAAAUCGUACCAGTT。
21.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAGAGACUUUGUCUCUUCGTT，反义链CGAAGAGACAAAGUCUCUCTT。
22.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUGUUUGGAUGAUAGGUGUTT，反义链ACACCUAUCAUCCAAACAGTT。
23.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUUACAUAGCUCGCGUCUCTT，反义链GAGACGCGAGCUAUGUAAGTT。
24.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GGAAGGAAGUUCUGUUGAATT，反义链UUCAACAGAACUUCCUUCCTT。
25.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CACUUCUUCUUUGCUCAGGTT，反义链CCUGAGCAAAGAAGAAGUGTT。
26.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CGCUGCUAUCAGUGAUUAUTT，反义链AUAAUCACUGAUAGCAGCGTT。
27.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCUGCCAACAAUGUGUGAUTT，反义链AUCACACAUUGUUGGCAGATT。
28.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUCCUAUUCGUAGUUGAAGTT，反义链CUUCAACUACGAAUAGGAGTT。
29.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGCCAACCAAGUAAUCGUUTT，反义链AACGAUUACUUGGUUGGCATT。
30.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCUGGAUAAAUCAGCUGGUTT，反义链ACCAGCUGAUUUAUCCAGATT。
31.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUAUGCCAUUAGUGCAAAGTT，反义链CUUUGCACUAAUGGCAUACTT。
32.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAAUAGAGCUCGCACCGUATT，反义链UACGGUGCGAGCUCUAUUCTT。
33.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UAGAGCUCGCACCGUAGCUTT，反义链AGCUACGGUGCGAGCUCUATT。
34.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUCAAUAGCCGCCACUAGATT，反义链UCUAGUGGCGGCUAUUGACTT。
35.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGUGACAGAGCCAUGCCUATT，反义链。UAGGCAUGGCUCUGUCACATT
36.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAUGCUUAGGAUAAUGGCCTT，反义链GGCCAUUAUCCUAAGCAUGTT。
37.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGGCCUCUCUUGUUCUUGCTT，反义链GCAAGAACAAGAGAGGCCATT。
38.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUUAUCACACCGUUUCUACTT，反义链GUAGAAACGGUGUGAUAAGTT。
39.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CGAGUGUGCGCAAGUAUUATT，反义链UAAUACUUGCGCACACUCGTT。
40.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUGAGAUGGUCAUGUGUGGTT，反义链CCACACAUGACCAUCUCACTT。
41.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CCAGGUGGAACAUCAUCCGTT，反义链CGGAUGAUGUUCCACCUGGTT。
42.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAUCAUCCGGUGAUGCUACTT，反义链GUAGCAUCACCGGAUGAUGTT。
43.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GCUGUUACAGCCAAUGUAATT，反义链UUACAUUGGCUGUAACAGCTT。
44.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAUAGCUGACAAGUAUGUCTT，反义链GACAUACUUGUCAGCUAUCTT。
45.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUAUGUCCGCAAUCUACAATT，反义链UUGUAGAUUGCGGACAUACTT。
46.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCUACAACACAGGCUCUAUTT，反义链AUAGAGCCUGUGUUGUAGATT。
47.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CACAGGCUCUAUGAGUGUCTT，反义链GACACUCAUAGAGCCUGUGTT。
48.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAGUAACUAUGCGGCUCAATT，反义链UUGAGCCGCAUAGUUACUGTT。
49.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUAUGCGGCUCAAGGUUUATT，反义链UAAACCUUGAGCCGCAUAGTT。
50.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGUGUUCAUGUCUGAGGCATT，反义链UGCCUCAGACAUGAACACATT。
51.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGUUGGACUGAGACUGACCTT，反义链GGUCAGUCUCAGUCCAACATT。
52.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAAGGAGAUGAUUACGUGUTT，反义链ACACGUAAUCAUCUCCUUGTT。
53.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GGAGAUGAUUACGUGUACCTT，反义链GGUACACGUAAUCAUCUCCTT。
54.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAAUAUUAGGCGCAGGCUGTT，反义链CAGCCUGCGCCUAAUAUUCTT。
55.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UAUUAGGCGCAGGCUGUUUTT，反义链AAACAGCCUGCGCCUAAUATT。
56.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GGUUCGUGUCACUGGCUAUTT，反义链AUAGCCAGUGACACGAACCTT。
57.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAUCCUAAUCAGGAGUAUGTT，反义链CAUACUCCUGAUUAGGAUGTT。
58.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUAAUGAUAACACCUCACGTT，反义链CGUGAGGUGUUAUCAUUAGTT。
59.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGAUAACACCUCACGGUACTT，反义链GUACCGUGAGGUGUUAUCATT。
60.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUCACAGACUUCACUUCGUTT，反义链ACGAAGUGAAGUCUGUGAATT。
61.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUGCUGCUAUGACCAUGUCTT，反义链GACAUGGUCAUAGCAGCACTT。
62.权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUGUAUCUAGGAGGUAUGATT，反义链UCAUACCUCCUAGAUACAGTT。
63.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GCUCCUAAUUACACUCAACTT，反义链GUUGAGUGUAAUUAGGAGCTT。
64.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCAAAUGUUGUCCGUGGUUTT，反义链AACCACGGACAACAUUUGATT。
65.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAACAAGUCACAGUCGGUGTT，反义链CACCGACUGUGACUUGUUGTT。
66.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAAGUCACAGUCGGUGAUUTT，反义链AAUCACCGACUGUGACUUGTT。
67.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUCACAGUCGGUGAUUAUUTT，反义链AAUAAUCACCGACUGUGACTT。
68.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CACUUACGAGAGUUUGUGUTT，反义链ACACAAACUCUCGUAAGUGTT。
69.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CCUAUAGAUGUAGUUCGUGTT，反义链CACGAACUACAUCUAUAGGTT。
70.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUUGCCUCUUGGUAUUAACTT，反义链GUUAAUACCAAGAGGCAACTT。
71.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GCCAACUACAUUUAUGCUCTT，反义链GAGCAUAAAUGUAGUUGGCTT。
72.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGGUACAAUCACAGAUGCUTT，反义链AGCAUCUGUGAUUGUACCATT。
73.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCACAGAUGCUGUUGAUUGTT，反义链CAAUCAACAGCAUCUGUGATT。
74.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCCACUUGCUGAACUCAAATT，反义链UUUGAGUUCAGCAAGUGGATT。
75.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGCUCUGUUAAGAGCUUUGTT，反义链CAAAGCUCUUAACAGAGCATT。
76.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GGAAUUUACCAGACCUCUATT，反义链UAGAGGUCUGGUAAAUUCCTT。
77.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CCUUUAAGUGCUAUGGCGUTT，反义链ACGCCAUAGCACUUAAAGGTT。
78.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUGCUAUGGCGUUUCUGCCTT，反义链GGCAGAAACGCCAUAGCACTT。
79.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GACAAAUAGCGCCAGGACATT，反义链UGUCCUGGCGCUAUUUGUCTT。
80.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UAGCGCCAGGACAAACUGGTT，反义链CCAGUUUGUCCUGGCGCUATT。
81.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUGCCAGAUGAUUUCAUGGTT，反义链CCAUGAAAUCAUCUGGCAATT。
82.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CCUUACAGAGUUGUAGUACTT，反义链GUACUACAACUCUGUAAGGTT。
83.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGGACUCACUGGUACUGGUTT，反义链ACCAGUACCAGUGAGUCCATT。
84.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CCAUUUCAACAAUUUGGCCTT，反义链GGCCAAAUUGUUGAAAUGGTT。
85.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAAUUUGGCCGUGAUGUUUTT，反义链AAACAUCACGGCCAAAUUGTT。
86.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUUGGCCGUGAUGUUUCUGTT，反义链CAGAAACAUCACGGCCAAATT。
87.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUGUAAUUACACCUGGAACTT，反义链GUUCCAGGUGUAAUUACACTT。
88.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUACACCUGGAACAAAUGCTT，反义链GCAUUUGUUCCAGGUGUAATT。
89.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGCUUCAUCUGAAGUUGCUTT，反义链AGCAACUUCAGAUGAAGCATT。
90.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAUGUUAACUGCACUGAUGTT，反义链CAUCAGUGCAGUUAACAUCTT。
91.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUGCACUGAUGUUUCUACATT，反义链UGUAGAAACAUCAGUGCAGTT。
92.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUCAUGCAGAUCAACUCACTT，反义链GUGAGUUGAUCUGCAUGAATT。
93.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GCAGGCUGUCUUAUAGGAGTT，反义链CUCCUAUAAGACAGCCUGCTT。
94.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CACCAUUGCUAUACCUACUTT，反义链AGUAGGUAUAGCAAUGGUGTT。
95.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUAAUGCCUGUUUCUAUGGTT，反义链CCAUAGAAACAGGCAUUACTT。
96.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGCCUGUUUCUAUGGCUAATT，反义链UUAGCCAUAGAAACAGGCATT。
97.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UAUGUACAUCUGCGGAGAUTT，反义链AUCUCCGCAGAUGUACAUATT。
98.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGUGCUAAUUUGCUUCUCCTT，反义链GGAGAAGCAAAUUAGCACATT。
99.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CUAAAUCGUGCACUCUCAGTT，反义链CUGAGAGUGCACGAUUUAGTT。
100.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCGUGCACUCUCAGGUAUUTT，反义链AAUACCUGAGAGUGCACGATT。
101.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CAGGAUCGCAACACACGUGTT，反义链CACGUGUGUUGCGAUCCUGTT。
102.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CACACGUGAAGUGUUCGCUTT，反义链AGCGAACACUUCACGUGUGTT。
103.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUGUUCGCUCAAGUCAAACTT，反义链GUUUGACUUGAGCGAACACTT。
104.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UAAGGUGACACUCGCUGAUTT，反义链AUCAGCGAGUGUCACCUUATT。
105.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GGUGACACUCGCUGAUGCUTT，反义链AGCAUCAGCGAGUGUCACCTT。
106.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GCAAUAUGGCGAAUGCCUATT，反义链UAGGCAUUCGCCAUAUUGCTT。
107.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UAUGGCGAAUGCCUAGGUGTT，反义链CACCUAGGCAUUCGCCAUATT。
108.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUUCAAUGGACUUACAGUGTT，反义链CACUGUAAGUCCAUUGAACTT。
109.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGGACUUACAGUGUUGCCATT，反义链UGGCAACACUGUAAGUCCATT。
110.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGGCAUAUAGGUUCAAUGGTT，反义链CCAUUGAACCUAUAUGCCATT。
111.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GCUGCAAGACGUUGUUAACTT，反义链GUUAACAACGUCUUGCAGCTT。
112.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GACGUUGUUAACCAGAAUGTT，反义链CAUUCUGGUUAACAACGUCTT。
113.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CCAGAAUGCUCAAGCAUUATT，反义链UAAUGCUUGAGCAUUCUGGTT。
114.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGAUAUCCUUUCGCGACUUTT，反义链AAGUCGCGAAAGGAUAUCATT。
115.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUCGAGGCGGAGGUACAAATT，反义链UUUGUACCUCCGCCUCGACTT。
116.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUACAGGCAGACUUCAAAGTT，反义链CUUUGAAGUCUGCCUGUAATT。
117.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GCCUUCAAACCUAUGUAACTT，反义链GUUACAUAGGUUUGAAGGCTT。
118.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGUCUGAGUGUGUUCUUGGTT，反义链CCAAGAACACACUCAGACATT。
119.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUUGUCAUGAAGGCAAAGCTT，反义链GCUUUGCCUUCAUGACAAATT。
120.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUGUGAUGUCGUUAUUGGCTT，反义链GCCAAUAACGACAUCACAATT。
121.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CACAGUUUAUGAUCCUCUGTT，反义链CAGAGGAUCAUAAACUGUGTT。
122.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CCUGAGCUUGACUCAUUCATT，反义链UGAAUGAGUCAAGCUCAGGTT。
123.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAAGAGCUGGACAAGUACUTT，反义链AGUACUUGUCCAGCUCUUCTT。
124.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAGCUGGACAAGUACUUCATT，反义链UGAAGUACUUGUCCAGCUCTT。
125.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链CGCUUCUGUCGUCAACAUUTT，反义链AAUGUUGACGACAGAAGCGTT。
126.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链AGAAAUUGACCGCCUCAAUTT，反义链AUUGAGGCGGUCAAUUUCUTT。
127.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GAAAUUGACCGCCUCAAUGTT，反义链CAUUGAGGCGGUCAAUUUCTT。
128.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUGACCGCCUCAAUGAGGUTT，反义链ACCUCAUUGAGGCGGUCAATT。
129.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCACUCAUUGACCUUCAAGTT，反义链CUUGAAGGUCAAUGAGUGATT。
130.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UGGCCUUGGUAUGUUUGGCTT，反义链GCCAAACAUACCAAGGCCATT。
131.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UUGCCAUCGUCAUGGUUACTT，反义链GUAACCAUGACGAUGGCAATT。
132.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链UCUUGCUUUGUUGCAUGACTT，反义链GUCAUGCAACAAAGCAAGATT。
133.权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，核苷酸序列(I)为正义链GUUUGAUGAGGAUGACUCUTT，反义链AGAGUCAUCCUCAUCAAACTT。
134.权利要求1至133中的任一所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，所述同源度以80％以上为佳。
135.权利要求1至133中的任一所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)的任何部份或全部经化学修饰后所形成的的小干扰核糖核酸分子。
136.权利要求135所述的攻击严重急性呼吸系统综合症(SARS)病毒的小干扰核糖核酸分子(SiRNA)，所述化学修饰包括对连接核苷酸的磷酸二酯键的部份修饰或用其它任何化学键取代。
137.权利要求135所述的攻攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)，所述化学修饰包括对这些SiRNA分子侧链上核糖的2位上的0H作任何化学的修饰和改变，和碱基上任何位置作化学修饰或改变。
138.权利要求1至133中的任一所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
139.权利要求134中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
140.权利要求135中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
141.权利要求136中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
142.权利要求137中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
全文摘要
本发明提供了攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其在制备治疗SARS以及与其感染相关的任何疾病的药物中的应用。它为双链RNA分子并且与具有以下特征的核苷酸序列至少70％的同源度正、负义链的长度均为21个核苷酸，正、负义链各自的3’端为两个连续的T，两条链除去3’端的TT以外的19个核苷酸上的碱基互补形成双链，正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致，每条链的碱基为G或C的核苷酸数量之和占除去3’端的TT以外的19个核苷酸数量的比例为30％－70％，序列(I)负链和其任意一个位置的突变体和已知人类基因和基因表达片段无同源性。
文档编号A61K31/7088GK1590545SQ0314086
公开日2005年3月9日 申请日期2003年6月4日 优先权日2003年6月4日
发明者丁佳逸 申请人:杭州新瑞佳生物医药技术开发有限公司