一类人类肝脏相关基因的制作方法

专利名称：一类人类肝脏相关基因的制作方法
技术领域：
本发明涉及生物技术领域，具体地，涉及一类基因，尤其涉及一类人类肝脏相关基因。
背景技术：
肝脏是人体内最大的消化腺。也是体内新陈代谢的中心站。据估计，在肝脏中发生的化学反应有500种以上，实验证明，动物在完全摘除肝脏后即使给予相应的治疗，最多也只能生存50多个小时。这说明肝脏是维持生命活动的一个必不可少的重要器官。肝脏的血流量极为丰富，约占心输出量的1/4。每分钟进入肝脏的血流量为1000-1200ml。肝脏的主要功能是进行糖的分解、贮存糖原；参与蛋白质、脂肪、维生素、激素的代谢；解毒；分泌胆汁；吞噬、防御机能；制造凝血因子；调节血容量及水电解质平衡；产生热量等。在胚胎时期肝脏还有造血功能。
肝脏疫病分为肝炎、肝硬化、脂肪肝、肝癌等。现代医学实验证明，肝病病毒侵入人体后，并不直接引起肝细胞的损害，只是在肝细胞内吸收营养赖以生存，并在肝细胞内复制、繁殖。其复制病毒的“零部件”如表面抗原(HBsAg)、e抗原(HBeAg)释放在肝细胞膜上，引起人体免疫系统对这些抗原物质产生免疫反应，这种反应造成肝细胞的损伤、坏死。免疫反应的强弱决定于肝脏受损程度及临床症状轻重。这场由病毒引发的、免疫系统对肝细胞的战争，使大约25％的患者的肝脏成为战火连绵的战场，肝脏的损伤由此加重。肝病的危害绝不仅仅限于肝脏本身，它还可以引起其它多种疾病。常见的有(1)糖尿病；(2)胰腺炎；(3)胆道感染；(4)功能性肾衰竭；(5)胆汗性肾病；(6)肾小球肾炎；(7)肾小管酸中毒；(8)溶血性贫血；(9)再生障碍性贫血；(10)心肌炎和心包炎；(11)结节性动脉炎；(12)消化性溃疡；(13)自发性腹膜炎；(14)性激素代谢紊乱；(15)甲状腺功能改变；(16)肝性骨病，等等。肝病不仅对患者的身体甚至生命造成危害，而且对患者心理上的打击也是十分沉重的。无论是肝病患者还是病毒携带者，在生活、社交、求职、升学等方面都会受到严重影响。
生物基因组中可转录表达的序列(即基因)仅占总序列的3-5％，对这部分序列进行测定，将直接导致新基因的发现，并获取基因组中与产业化关系最为密切的信息。
人类肝脏相关基因是指在人类肝脏中表达的相关基因，其与一些肝脏疾病相关，因此，研究人类肝脏相关基因对探索肝脏疾病的发病机理及研制肝病的治疗药物具有重要意义。

发明内容
本发明要解决的技术问题是提供一类人类肝脏相关基因。
本发明要解决的技术问题通过如下技术方案实现本发明提供一类人类肝脏相关基因，其包括以下序列的基因(a)SEQ ID No.1～SEQ ID No.30所示的序列；(b)SEQ ID No.1～SEQ ID No.30所示的序列中每条序列的互补序列；(c)与SEQ ID No.1～SEQ ID No.30所示的序列中每条序列有至少70％同源性的序列，及(d)上述(a)～(c)中一条或数条的组合。
较佳地，所述序列包括具有SEQ ID No.1～SEQ ID No.30所示的序列。
本发明还提供了一种探针分子，所述的探针分子含有上述序列中约8-100个连续的核苷酸。
本发明的人类肝脏相关基因，在研究肝脏疾病的致病机理以及开发治疗肝脏疾病的药物中发挥重要作用。
具体实施例方式
下面结合具体实施例，进一步阐述本发明。应理解，这些实施例仅用于说明本发明而不是限制本发明的范围。下列实施例中未注明具体条件的实验方法，通常按照常规条件如Sambrook等人，分子克隆实验室手册(New YorkCold Spring HarborLaboratory Press，1989)中所述的条件，或按照制造厂商所建议的条件。
实施例1人肝脏组织的mRNA的分离组织分离(Tissue isolation)肝脏来源于5个成年男性，在肝脏切除手术后，将肝脏组织立即置于液氮中冷冻保存。
mRNA的分离(mRNA isolation)取出肝脏组织，用研钵研碎，加入盛有裂解液的50ml管，充分振荡后，再移入玻璃匀浆器内，匀浆后移至50ml新管，抽提总RNA(TRIzol Reagents，Gibco，NY，USA)。用甲醛变性胶电泳鉴定总RNA质量。用带Oligod(T)的纤维素柱分离总RNA中的mRNA，定量。
实施例2cDNA文库的构建(Constuction of cDNA library)以mRNA为模板，合成双链cDNA。补平末端后，加含EcoRI切点的接头。磷酸化EcoRI末端后，用XhoI限制性内切酶消化1.5小时，再进行片断分离。过柱筛选长度＞500bp的片段，用酚-氯仿抽提，乙醇沉淀，无菌水溶解，连接至Uni-ZAP XR载体(Strategene，CA9203，USA)，以ZAP-cDNA Gigapack III Gold Cloning Kit(Strategene，CA9203，USA)进行包装，宿主菌使用XL 1 Blue MRF’(Strategene，CA9203，USA)细菌。涂板并测定滴度。
实施例3测序及数据库建立(Seqencing and Database Constructing)挑选文库中有外源片段插入的克隆，扩增后抽提质粒(Qiagen Germany)，用T3和T7作为3’和5’端的通用引物，采用终止物荧光标记(Big-Dye，Perkin-Elmer，USA)的方法，在ABI 377测序仪(Perkin-Elmer，USA)上进行EST大规模测序。测序结果用FACTURA软件去除载体序列，传输到SUN Ultra 450Server上进行下一步的处理。所有的序列信息再用GCG软件包(Wisconsin group，USA)中的BLAST和FASTA软件搜索已有的数据库(Genebank+EMBL)，将无同源性或同源性低于95％的序列视为新基因建立数据库。
实施例4基因的全长克隆(Cloning of Full-length cDNA)在得到的新基因片段序列信息基础上，进行cDNA全长克隆，分两阶段进行(1)“电子克隆”(Electronic Cloning)以新基因片段序列作为探针搜寻dbEST数据库，将重叠序列＞50bp，同源性在98％以上的表达序列标签(Expressed Sequence Tag，简称“EST”)序列认为同一序列(Consensus Sequence)，取出并用AUTOASSEMBLER软件进行连接，部分EST可以延伸探针序列。再用STRIDER软件分析被延伸的序列是否具有完整的开放阅读框架(OpenReading Frame，ORF)，用BLAST搜寻Genbank或SwissProt以确定该序列的核苷酸和氨基酸水平上是否与其他物种有同源性，以帮助判别所得到的基因全长完整性如何。通过电子克隆的方法，通常可获取人肝脏相关基因的全长序列。
(2)cDNA末端快速扩增(Rapid Amplification of cDNA Ends，RACE)如果通过“电子克隆”方法仍未得到完整的cDNA全长，则在已有序列5’或3’端设计引物，在人类肝脏Marathon-Ready cDNA文库(Clontech Lab，Inc，USA)中进行长距离PCR反应。然后对PCR产物克隆、测序。用AUTOASSEMBLER及STRIDER软件分析被延长的序列有无完整的ORF，如无，重复上述过程直至获得全长。
(3)RT-PCR对于5’和3’端的已知的序列，如果中间有一段间隙(gap)无法从已有的公共数据库或自身数据库获得，可考虑采用RT-PCR的方法。在序列5’端设计引物，3’端引物采用Oligo-dT，在肝脏总RNA库中进行扩增。然后对产物进行克隆、测序。最后拼接便获得全长。
通过组合使用上述3种方法，可获得人肝脏相关蛋白的全长编码序列。
序列表<110>上海人类基因组研究中心<120>一类人类肝脏相关基因(4)<130>NP-10162<160>30<210>1<211>1559<212>DNA<213>Homo sapiens<400>11 acttttgggc aggtgtcagc gcccgtgtca ccgccacgtc gcggacatgg tgatttcaga61 aagtatggat atactcttca gaataagagg aggccttgat ttggcttttc agctagctac121 tcctaatgaa atttttctca agaaggcact gaaacatgtg ttgagtgacc tgtcaactaa181 gctgtcttca aacgcccttg tgttcagaat ttgccacagt tcagtgtata tatggcctag241 cagtgacata aacaccattc ctggagaact gactgatgct tctgcttgta agaacatact301 gcgctttgtt caatttgagc cagaagaaga tataaaaaga aaattcatga gaaagaagga361 caaaaagtta tcagacatgc atcaaatagt aaatatagat cttatgctgg aaatgtcaac421 ctccctggca gctgtaacgc ccatcattga aagggaaagc ggaggacacc attatgttaa481 tatgacttta cctgtcgatg cagttatatc tgttgctcca gaagaaacat ggggaaaagt541 tcgtaaactc ctggttgatg caattcataa tcaactaact gacatggaaa aatgtatttt601 gaaatatatg aaaggaacat ctattgtggt ccctgaacca ctgcactttt tattaccagg661 gaaaaaaaat cttgtaacaa tttcatatcc ttcaggaata ccagatggcc agctgcaggc721 ctataggaag gagttacatg gtcttttcaa tctgcctcac gacagaccct atttcaaaag781 gtctaatgct tatcactttc cagatgagcc atacaaagat ggttacatta gaaatccaca841 tacttacctt aatccaccta acatggagac tggtatgatt tatgtggtcc agggcatata901 tggctatcat cattatatgc aggatcgcat agatgacaat ggctggggct gtgcttatcg961 atctctgcag actatctgct cttggttcaa acatcaggga tacacagaga ggtccattcc1021 aacacacaga gaaattcagc aggctctagt cgatgccggg gacaaaccag caacatttgt1081 cggatcgcgg caatggattg gatctattga ggtgcagctg gtactaaacc aattgatcgg1141 tataacgtca aaaatcctgt ttgtcagcca aggttcagaa attgcctctc aaggacggga1201 actggctaat catttccaaa gtgaaggaac tccagttatg atcgggggag gagttttggc1261 ccacacaata ctaggagttg catggaatga gattacaggg cagataaagt ttctgattct1321 agatccacat tataccggtg ctgaagacct gcaagttatt ttggaaaagg gctggtgcgg1381 atggaagggc ccagattttt ggaacaagga tgcatactat aacttatgtc ttcctcagcg1441 accaaatatg atttaaaata tcttggagtc aaagactgca gtagagtggt attataaatt1501 tgtgaataaa gaatcagttt aatttttcac attaaatcct ggttctagtt tgaccattt
<210>2<211>1680<212>DNA<213>Homo sapiens<400>21 agagagctgt ttactaggca cgactgcgaa ggcaaggggg caccagctca ggactgcatc61 tgcctgccat ttcccttcca ctcctccttt ctggagtctg acattagaaa gccagcgaga121 aggaagattc aaacaaccaa ccctgatttc ctgcttctcc ttttcatgag tgttcctgtg181 gtctctgcac ctcctttctg tcccccggca gagggcagta gagatggccg gcccaaggcc241 tcggtggcgc gaccagctgc tgttcatgag catcatagtc ctcgtgattg tggtcatctg301 cctgatgtta tacgctcttc tctgggaggc tggcaacctc actgacctgc ccaacctgag361 aatcggcttc tataacttct gcctgtggaa tgaggacacc agcaccctac agtgtcacca421 gttccctgag ctggaagccc tgggggtgcc tcgggttggc ctgggcctgg ccaggcttgg481 cgtgtacggg tccctggtcc tcaccctctt tgccccccag cctctcctcc tagcccagtg541 caacagtgat gagagagcgt ggcggctggc agtgggcttc ctggctgtgt cctctgtgct601 gctggcaggc ggcctgggcc tcttcctctc ctatgtgtgg aagtgggtca ggctctccct661 cccggggcct gggtttctag ctctgggcag cgcccaggcc ttactcatcc tcttgcttat721 agccatggct gtgttccctc tgagggctga gagggctgag agcaagcttg agagctgcta781 aaggcttacg tgattgcaag ggttcagttc caaccatagt cagaggtggc acatctgctc841 agccatctca ttttacagct aacgctgatc tccagctcca gcgatggaac ccactacaga901 ggaggtgggg cccctgtgtc aaagaggccg aggggcagca agggcagcca gggcacctgt961 gacttcttag tacaagattg tctgtccttc aggacttcca aggctcccaa agactcccta1021 aaccatgcag ctcattgtca caccaattcc tgctttaatt aatggatctg agcaaatctt1081 cctctagctt caggagggtg gggagggagt gattgccgtc atggggccag acttccaggc1141 tgatttgcca aatgccaaaa tgaaacctag caaagaactt acggcaacaa acgaggacat1201 taaaagagcg agcacctcag tgtctctggg gacatggtta aggagcttcc actcagccca1261 ccatagtgag tgggccgcca taagccatca ctggaactcc aaccccagag gtccaggagt1321 gatctctgag tgactcaaca aagacaggac acatggggta caaagacaag gcttgactgc1381 ttcaaagctt ccctggacct gaagccagac agggcagagg cgtccgctga caaatcactc1441 ccatgatgag accctggagg actccaaatc ctcgctgtga acaggactgg acggttgcgc1501 acaaacaaac gctgccaccc tccacttccc aacccagaac ttggaaagac attagcacaa1561 cttacgcatt ggggaattgt gtgtattttc tagcacttgt gtattggaaa acctgtatgg1621 cagtgattta ttcatatatt cctgtccaaa gccacactga aaacagaggc agagacatgt<210>3<211>1474<212>DNA<213>Homo sapiens<400>3
1 agacgccggg ggcggacggg aggaccggag gaccgaggac agaaagattg gtggacagga61 gcagcggccg gtggggaggg cgctcggcgg cggcctgcgg ccatggccac cgtgatggca121 gcgacggcgg cggagcgggc ggtgctggag gaggagttcc gctggctgct gcacgacgag181 gtgcacgctg tgttgaagca gctgcaggac atcctcaagg aggcctctct gcgcttcact241 ctgccgggct ccggcactga ggggcccgcc aagcaagaga acttcatcct aggcagctgt301 ggcacagacc aggtgaaggg tgtgctgact ctgcaggggg atgccctcag ccaggcggat361 gtgaacctga agatgccccg gaacaaccag ctgctgcact tcgccttccg ggaggacaag421 cagtggaagc tgcagcagat ccaggatgcc agaaaccatg tgagccaagc catttacctg481 cttaccagcc gggaccagag ctaccagttc aagacgggcg ctgaggtcct caagctgatg541 gacgcagtga tgctgcagct gaccagagcc cgaaaccggc tcaccacccc cgccaccctc601 accctccccg agatcgccgc cagcggcctc acgcggatgt tcgcccctgc cctgccgtcc661 gacctgctgg tcaacgtcta catcaacctc aacaagctct gcctcacggt gtaccagctg721 catgccctgc agcccaactc caccaagaac ttccgcccag ctgggggcgc ggtgctgcat781 agccctgggg ccatgttcga gtggggctct cagcgcctgg aggtgagcca cgtgcacaaa841 gtggagtgcg tgatcccctg gctcaacgac gccctggtct acttcaccgt ctccctgcag901 ctctgccagc agctcaagga caagatctcc gtgttctcca gctactggag ctacagaccc961 ttctgatcac agcacccagg agcttgtctc caggaaggcg gccccgtccc ctactcatac1021 ccaccacaga gcaccagcca gtgccaacgc caggctgcta tttatctccc tatcccaccc1081 cctaccccac ctaacacatt tgcactgcca ggaatggaca ctggaagtgc caggaggaag1141 gaaggctggt ttggtggggt agtggggagg tcagggaggc ggggccaagg gtgtcccaca1201 ttcccaacac cgccctctga tcaccatggg aatctttgga ctcaggacag ggccaggtgc1261 agggctctcc ctcctctccc cttcgctgtc ccctccccct ggagggcatg gtgtcggggg1321 gtggcactga gctatgagtc ccggggatgg tgaggaacgc cacagacaga gccaccctag1381 gagtgagtat agtgctggtg actgtgtttc atagccccag tccagggctg tctaagaaat1441 aaagatcatc agactccaaa aaaaaaaaaa aaaa<210>4<211>1706<212>DNA<213>Homo sapiens<400>41 agataatgtt aacaatgtga tttagagtgg aagcaatacc agatagtcta acaatgtgat61 ttagaatagg ggctttggat caaatggtat cagctcaact tcaggaggag ctggatgcta121 agatccacca tgagggaagt caccatgtta cacgatggag gcccaataaa aacactggac181 acaaggcttg ggtgaacagg ccttcacgat gaccagagac agaagcccct gacttggcta241 aagatacttc tgctctccct atccccacat cctctttcag ttacgcatca cctcactcct301 tctgaaccat atggttctga tgtcagagcc agtgtagtaa agagcttctg ctgttcctga361 gaactgttgc tgctggaagt gatgcttcca ctgctacagc tggtacctgc taagctgctc421 aactcctctt gctccttgga gaagacactg cagtgcagct gttccttcca tgggattccc481 acaccctctg tgcagtggtg gatgggagga gtccccgtgg gtgtggatgg catggatggc541 agcctccaag tgacttccac catgcttggc ccctgggcta acagcaccat cagcctaact601 gaagagccag aaatgggcat gagacttctc tgtgagggga agaaccaaaa cggaacccat
661 gctttgagca tcctactgat gtcaagaaag agttctttgg ctgcccaggc cttcgtgaaa721 gggctgatcc agggtgctat ctatgcggga attgtaattg cgctgctctt cctctgcctc781 ctccctctca tagtgaaaca tatcagaaag aagcaggcga agaaagctgc agcgatcaga841 gcaaaaaaga gctctaaagt cagagcaagc caagaacttg agatgtctct gaagcctgag901 gaaccaggaa aacccgtagt cgccacattt tctgagagcc ggatattgga aaagcaagat961 aaacgagcca gctaagcctg tggaacatgc ctcatacctg gagtcgccat tatccctgga1021 attacaaaga tctgcaaaat ttatagcgct cacagaaacc ctggaggctg taataaacct1081 ggagccccct ggactctcct cagctcacaa aaccctctca attcctacac atcccttgac1141 actcattctc cattgaatag gtggttactc ttagacctag tcttagaacc tctgaagaca1201 cactttgtaa tttgttgttt ggctaaatga gaagaaatct gtgccaccct gggaaggtgt1261 caaaagaagg aaaaatacat gtgacaatat gaatcaagtc catcagcaag ttacttttga1321 gcgcctactg tgtgtcagtg cctgagatac acctacaaga gcgccaggct ttcaagcctt1381 catatctgga tagaatccca acttcagtgc ttggtggctg tctatctttg gacaagatct1441 ttcattcccc atcctttgaa catcacatga cccatatctg ggtggagaat gggtgaaaag1501 tactgttcag agatgcaggt gagaaaaaac atgacgatgg gccctgaatg ccaagattca1561 ttggagcttt ggagctttat cttgtaggac cttatcctga ctcccttaga atgtaagttc1621 caagagaaca gggactttgt ctgccttgtt ttctactttt atcaccagca cccagaatga1681 tgcctaaaat acaataagat ctcaag<210>5<211>1768<212>DNA<213>Homo sapiens<400>51 agtgcgggag ccggagcgga gccggggccg gagcgggcgg aatggagccc ctgcgcgcgc61 ccgcgctgcg ccgcctgctg ccgccgctgc tgctcctgct gctgtcactg cccccccgcg121 cccgggccaa gtacgtgcgg ggcaacctca gttccaagga ggactgggtg ttcctgacaa181 gattttgttt cctctcggat tacggccgac tggacttccg tttccgctac cctgaggcca241 agtgctgtca gaacatcctc ctctattttg atgacccatc ccagtggcca gccgtgtaca301 aggcagggga caaggactgc ctggccaagg agtcagtgat ccggccggag aacaaccagg361 tcatcaacct caccacccag tatgcctggt ccggctgtca ggtggtatca gaggagggaa421 cccgctacct gagctgctcc agtggccgca gcttccgctc aggtgatgga ttgcagctgg481 agtatgagat ggtcctcacc aatggcaagt ccttctggac acgacacttc tccgctgatg541 agtttgggat cctggagaca gatgtgacct tcctcctcat cttcatcctc atcttcttcc601 tctcttgtta ctttggatat ttgctgaaag gtcgtcagtt gctccacaca acttataaaa661 tgttcatggc cgcagcagga gtagaggtcc tgagcctcct atttttctgc atctactggg721 gtcaatatgc caccgatggc attggcaacg agagtgtgaa gatcttggcc aagctgctct781 tctcctccag cttcctcatc ttcctgctga tgcttatcct cctggggaag ggattcacgg841 tgacacgggg ccgcatcagc cacgcgggct ccgtgaagtt gcctgtctac atgaccctgt901 acacgctcac ccatgtggtg ctgctcatct acgaggcgga attctttgac ccaggccagg961 tactgtacac gtatgagtcg ccggccggct acgggctcat tggactgcag gtggcggcct1021 acgtgtggtt ctgctatgct gtgcttgtct cactgcgaca ctttcctgag aagcagcctt
1081 tttatgtgcc cttctttgct gcctataccc tctggttctt tgcggttcct gtcatggccc1141 tgattgccaa tttcggcatc cccaagtggg cccgggagaa gattgtcaat ggcatccagc1201 tggggatcca cttgtacgcc catggcgtgt ttctgatcat gacccgcccg tcagcggcca1261 acaagaactt cccgtaccac gtgcgcacgt cgcagatcgc ttcagccgga gtccctggac1321 ccggagggag ccaatccgct gacaaggcct tcccgcagca cgtctatggg aacgtgacgt1381 ttatcagcga ctcggtgccc aacttcacgg agctcttctc catccccccg cccgccacct1441 tccccctgcc ccgagcggcg ccggattctg ggctcccgct gttccgtgac ctccggcccc1501 ctggccccct tcgagacctc tgaccccgct ggactccgga acacccgtgg tgaccgccgg1561 gaccctgcct gtgactctcc aggactctgc gaccccggga tggatattgc gatgctggtc1621 tcgaccctga aaccctccct cggatctgtg acctcggacc cgtactccat ctgccgcatc1681 tccattccgg gggccttccc tcgggtccct ggcagaaaga cattttaccc cttcttgcca1741 aaataaaaaa ggattcgttt ttatctat<210>6<211>1402<212>DNA<213>Homo sapiens<400>61 gggtaagtat gtgtttgtac ttatttgtta tactggaaac aggagagata tttgtaatta61 tttctgctta aaagatatca gaatagttat ttactattca ggtatcagat ttgtttaaaa121 atgacattta acttgattat atcattattt tcttttccat taagccctaa caatttttaa181 agccatgaaa taacttaaaa aacagaagta atttaatctt accctctcct ttggaaagaa241 aatattcctt ttttaaagtg aaagcaagtt tcaaaaaaag aaaaggaata aagaacagct301 actccatagg cagagcagcg gcctggtctg cttgactgag tatccttgca gttatttctg361 gattatatgc taaacaaggg gtggattatt catgagtttt ccaggaaagg ggtggagatt421 tcccggaact gagagttcct ccccttttta gaccatatag ggtaacttcc ggacattgcc481 ttgggatttc taaactgtca tggcgctggc aggagcgcct tttagcatgc taatatatta541 taattagtgt ataatgagca gcggggacga ccagaggtct ctttcattgc catcttggtt601 ttggtgagtt ttggccggct tctttatggc atcctgtgtt atcagcaggg tctttgtgac661 ctgtatcctg tgccgacctc ctatctcatc ctgtgactaa gaaaatattc ttttaatttg721 acaaatcaag ttggatctca ttgtgctaaa aaaggttttt aaaaatatta tccaatacag781 tgccatctag tgacaaatca tttacttgct ggttattgaa aatagttgac tacaagtttt841 atgtcctgat aagtcaggaa cttcacttct aattgtgcaa attcttaaga tattttaagc901 gactatttct aaataaataa aatatttgta aatagagagc tggaaaatat tttctaaccc961 tcaggtttta tacatatgta tcacaatgtg tcttatttaa tgccacgtgg acccaggagt1021 aaaatcaaaa tcagtgtttt gtctaataag gtggtaatag gattatttta gaaatgtgat1081 gtaaaggaat gagcatggct ttaaaatcaa acagacacga gtttgtctat ttggacttat1141 ttttcttatg acttagcagg taattactac ctgcttggaa gtgcaccaag cactatatag1201 gtactgcctc attacatatt cacaaaactc tataggtatt ttacaaatga ggaaaccggc1261 caggcgcggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc gggggaatca1321 cgaggtctgg agatccagac catcctggct aacacagtga aaccccgtct ctactaaaaa1381 tacaaaaaaa aaaaaaaaaa aa
<210>7<211>1515<212>DNA<213>Homo sapiens<400>71 actagcggag ccgcgaggga gaggccgcgg ccccttcccg ttgcctgcgg ccaccggccg61 gcattcagag cccctcgcct ggcgctaaat ttaaaaacgt aacacgagca gcaggctggt121 ctcggaaacg aaacgaaatt cggtccctgg gcctcctccc gggcgctgcc ggtccctcag181 cgcgccgcgc cacccggaac agacccttct cccgccattt tcggcggggc tgggagactg241 aggcccgcgg cgctgagcct gcggcgcccc ggaagaggcg ggcggcatgg ccgctggcgt301 ggactgcggg gacggggttg gcgcccggca gcacgtgttc ctggtttcag aatatttaaa361 agatgcttca aagaagatga aaaatgggct aatgtttgta aaactggtta acccctgttc421 aggagaagga gccatttact tgttcaatat gtgtctacag cagctgcttg aagtaaaagt481 tttcaaggaa aaacaccatt cttggtttat aaatcaatca gttcaatcag gaggtcttct541 ccattttgcc acacctgtgg atcctctatt tctgcttctc cactacctca taaaggctga601 taaggagggg aagtttcagc cccttgatca agttgtggtg gataacgtgt ttccaaattg661 catcttgttg ctgaaacttc ctggacttga gaagttactt catcatgtga cagaggaaaa721 aggtaatcca gaaatagaca acaagaaata ttacaagtac agcaaagaga agacattaaa781 gtggctggaa aaaaaggtta atcaaactgt ggcagcatta aaaaccaata atgtgaatgt841 cagttcccgg gtacagtcaa ctgcattttt ctctggtgac caagcttcca ctgacaagga901 agaggattat attcgttatg cccatggtct gatatctgac tacatcccta aagaattaag961 tgatgactta tctaaatact taaagcttcc agaaccttca gcctcattgc caaatcctcc1021 atcaaagaaa ataaagttat cagatgagcc tgtagaagca aaagaagatt acactaagtt1081 taatactaaa gatttgaaga ctgaaaagaa aaatagcaaa atgactgcag ctcagaaggc1141 tttggctaaa gttgacaaga gtggaatgaa aagtattgat accttttttg gggtaaaaaa1201 taaaaaaaaa attggaaagg tttgaaactt tgaaaataaa atctagcaaa aatatttgct1261 ttttacatgt ttcagtttgt ccttcctgac tgttaatgac tacctttggt tgggggaagg1321 aagaggccaa tttcatgttc tcttaaacat ttctttgcat ttggtttttg tgttcctgaa1381 caaaatatgg gaaagtgtct aacttcatgg ctatggcctt ttggagtctc atctgacata1441 atgaaaagta atcacttgaa gagaattaac atatagcatc atgattttct caataaactg1501 atgtgtgaca atgtt<210>8<211>815<212>DNA<213>Homo sapiens<400>81 ataaatcaat atttttagaa taaaggttca caaagaccta aatatatgtg acttaacata61 tgatgaagat acaattttag taagagagga aaggatggat tctttaataa atagtatggg
121 accatgccta ggaatttagg aaactaataa agctgactcc ctcctatata ctatatgcca181 aaataaattt aatatgggtt aagtatttaa ttaaaaacat aacactctta gatatttcag241 atgaataatt ttaatatatg aaatcaagaa ggtccttcta agtgcgagtc aaacaccatg301 aatttaaagg ttaatagatg gactaattta agatttaaag accctttatt caaaaagcag361 catcaaaaaa atggaaatac aaattacaca ctggcaatta ttatttatga catatattca421 gatgaagatg tattttcttt ataaagagct cttacaaatc cataataaaa agacaatctg481 aaaacctgta agatagagaa aaagtagcaa aaattaagaa gaggtatatc acaagagaaa541 tggcagttcc gtatgtacat caaagtggta ctctattagg actgacggac gatttacaag601 tgaataattt ggctatcggt tggaagatgg aagaagtagg cgaatcgcac tgtggacggg661 tttctctcct gggggggggg gagaaataat cacttcgaag ggggggaatt caaatgaatt721 caatttaagg ttcttttaaa aaaaaaaatt gggcggccaa attcactggc gcaaaagatg781 taacggaagg taaagcggga aagtgttgcc gcggc<210>9<211>1843<212>DNA<213>Homo sapiens<400>91 agtcgtaggc gctggccgct gacatgttga ggactacgcg cggcccaggc ctgggccccc61 cgctgctcca ggccgcgctg ggccttgggc gggctgggtg gcactggcct gcgggccggg121 cggcgagcgg ggggcgcggg cgggcctggc tgcagcccac gggccgggag acgggtgtgc181 aggtgtacaa cagcctcacc gggaggaagg aacccctaat cgtggcgcac gccgaagccg241 cctcctggta tagctgtgga ccaactgtat atgatcatgc gcaccttggc catgcttgct301 catatgttag atttgatatc attcgaagga tcctaaccaa ggtttttgga tgcagcatag361 tcatggtgat gggtattaca gatgtagatg ataaaatcat caaaagagcc aatgagatga421 atatttcccc cgcttccctc gccagtcttt atgaggaaga cttcaagcag gacatggcag481 ccctgaaggt tctcccaccc acggtgtacc tgagggtaac cgaaaatatt cctcagataa541 tttctttcat tgaaggaatc attgctcgtg ggaacgctta ttcaacggca aaaggcaatg601 tctacttcga tctgaagtct agaggagaca agtatggcaa attggtcggc gtggtccctg661 gtccagtcgg agagccagcg gactctgaca agcgtcatgc cagtgacttc gccctgtgga721 aggcggccaa accccaggag gtgttctggg cctctccctg gggacccggg aggccgggct781 ggcacatcga gtgctctgcc atcgctagta tggtatttgg aagtcaactg gatatccatt841 caggtgggat agatttagct tttccacatc atgagaacga aattgcacag tgcgaagtct901 ttcatcagtg cgagcagtgg ggaaattatt ttctgcattc tgggcatttg cacgccaaag961 gcaaagaaga aaaaatgtcc aaatcattaa agaactacat tactattaag gactttctga1021 agaccttttc ccccgatgtc ttccggttct tctgcctgcg gagcagctac cgctcagcca1081 tcgactacag tgacagcgcc atgctccaag ctcagcagct gctcctgggg ctgggctctt1141 tcctggagga cgcacgtgcc tacatgaagg ggcagctggc ctgcggctcc gtcagggaag1201 cgatgctgtg ggagaggctc tccagcacca agagggccgt gaaggcggcc ttggcagatg1261 attttgacac acccagggtg gttgatgcca tcctgggcct tgcacaccac gggaatggac1321 agctcagggc gtccctgaag gaacctgaag ggccgagaag tcctgctgtg tttggtgcca1381 tcatctctta ctttgaacag ttttttgaaa ctgttggaat ttctctggca aatcaacagt
1441 acgtttcagg agacggcagc gaggctacct tgcatggtgt ggtggacgag ctggtgcggt1501 tccggcagaa ggtccggcag tttgcgctgg ccatgcccga ggccacgggg gacgcccggc1561 ggcagcagct cctagaaagg cagcccctgc tggaagcatg cgacaccctg cgccggggcc1621 tgactgccca cggcatcaac atcaaggaca gaagcagtac aacatccacg tgggaactgc1681 tggatcaaag gacaaaagac caaaaatcag cgggctgagg atggagcaca gccatgaacc1741 tgctcacgac aagacgcacc catgcttctc agggtcaagg ctttatgtta aagcttcctg1801 tcggggctgc taggtcagca ttaaagtaag gcaaccaaca gtg<210>10<211>514<212>DNA<213>Homo sapiens<400>101 aaaggcaaag aaggttttta tttaagtgac aacatttgag agctaaaaac cagctcacat61 caaaatcaag acccagttgt tgaaatcttt taactccata atgctgtttt tgtcttgtta121 gaaatctgat atcttacatt agcgtttcta acggattttg tacaaggcag ccataaggaa181 tataataaac ctttttcacc acagaaccat ctgtcacaga taatactgaa agttacacac241 ttaggaacag tcagaccaca gacaaggtca gactggctgc caccaccaag taaacaacta301 gaaaaggaca gcggggtcca agggtggggg tccctgtgca cgagtcgccc tcctctggcc361 tgccccccct cgggtcacct gcttctcctt tgccccaaag agggtggagt caaatgcaga421 ttttcctccc aactgcctgt tagtgtctca acaaggagag cagagcccag gtcaggcctc481 actgcttgga cttaacccta actatgattt ttac<210>11<211>2299<212>DNA<213>Homo sapiens<400>111 agcagctcat cgagatgggg aacaggctcc gtgcagagct gggccgaccc gaaaggtggc61 tgttgcacca cgccctccct cctgcccctg aggcccggaa gccaggcgag gagcccagga121 ggcctttgga tcgcagccca cctttgggac aggtgcagcc ccattttaca tctcaggacg181 ccaagagtgc cgaggatgag gctccttcca gacacttggg aaagcaccag ccccgctcag241 cacaggtggg cagcagactt gacgccctgc aaggcccgaa gacacaacac agcatccaca301 cggtgacctg taaatcacct cggcagaaag aagacaggtc cccaaagcca ccccaggctc361 cccagcaccc tgaggagcat ggtcgccaat cccacagctc ctcctccttt gccagtggca421 ccctccagga catgtggagg ttgctagacc tgggatccag cccttctggt gtcacctccc481 agggtgactc aactccagaa atggggtctc actatgtcac ccaggctggt ctcgaactcc541 tgggctcaag cagtcctgcc gccttggcct cccaaagtgc tgagatgaca ggtgtgggcc601 ccacgcccag cctggcgtgg agtggagccc ttcacccaaa catgaaccag gaggcgagct661 tggtaaggag cgcgtgggct ccaggaatgc gagggggaat gaatggaggc agctcctcag
721 tgtgcaaaaa catgcagcgc gggcctcact ggtcaccatc acagcagcct tgcagtggga781 tcaggacagt cctgctgtcc aggaaggaga ggaccctgct ctcttgtttc tcactacctg841 ctcctgtcgt tctagtccca ttgctgctct caggacaagc tgtgactgag agagcaggtc901 acgctggtga cattttatga ggctggatgc acagccccac agcaccttgt cactgaagct961 acaggaatcc aagaaccagt gctctggcca agaagggagc actggggtgc cctgaatggc1021 acggacaacc ccagcccccc gccttcactg attatcatga cctgtggctt ctgaaaggac1081 agggcagtct tggaactttc tgagaaacag atggtcaagt agatgtctgt tagctctttt1141 cttgaaattg tagtgacgaa accatgactg ccacttagga aagtaacttg tgttgaaata1201 acttttagaa caaagtaaat acattaagaa ataaccaaat cggcttactt tctgataata1261 tttattctat gcccacacaa cggctggcac tcacttctgc ttctggccag gccgtagtta1321 caaggaccag actttaatgt tcctccatga acaactagaa aactggacaa agtatatgaa1381 acaactgttt gcagacattg gacaactggt caaacaagac cgagatcccc aacaagaccg1441 agaccctgga cgagtccgag atcccggaca agaccgccac ccttgttgga agggagacag1501 gcaaggtgaa ccctggggcc ctggccttct gcctgaaggc cgtttctggg ctgccggcac1561 agggagggaa gcagggcctg agcaaagctg agcaccctta cggagctgag actgcactag1621 ggtctgggga cacagaagga gccggcattt cagggcagaa tcccgcaagg aggaaactgc1681 agaaaagagc tccagaaatc tgcacagggt tctcttgagt ctgtactgag gaccagcctg1741 tacatgtata gaagaaaact ccacaaagcc aggcaaagag gagaaaggag catgtaaggt1801 gaacaacttc cagacctcgc acacggtcat gacatactga agctccagcc agggggatgg1861 gtccccagtg atcactgtgg acattcagtg gagactcagg aggagccaca ccgtgggaac1921 agggctgatg ctgtctgcag tgaaggctcg tctagaacct gcctgagaaa ctgcagctac1981 agaaatccaa ggcctggcat ggcggctcac gcctgtaatc ccagaacttt gggaagccga2041 ggtgggcaga tcacctgagg ccaggagttc acaaccagcc tggtcaactt ggtaaaaccc2101 cgtctctact aaaaatacaa aaattagtca ggtgtggtgg tgcatgcctg taatcccagc2161 tactcaggag gctgaggcat gagaatcact tgaacctggg aagcagaggt tgcagtgagc2221 cgagatcgcg ccactgcact ctagcctgag tgacagagca gactcctgtc tcaaaaaaaa2281 aaaaaaaaaa aaaaaaaaa<210>12<211>2002<212>DNA<213>Homo sapiens<400>121 agagtccagg gagagtgcgc gggcggccgc cggctgaatg aagcctggga cgcgggagcc61 gcgccgcgcg cagtgtctgc agtgccggag gtctgggagg ctccgggcga agcctccctg121 ctgcaggtta tgatgatgtc agacaatgct aaaggcagag cagctcattc atggaagaaa181 agagggagta tttcttctct aagtaatcat gaattttggc gaaaggaaat tcatgggcgc241 atcaaagatt ctatgagtac tgtgtcttat atggaagaac ccagtcagcg tgatgatatc301 tctcgcctta cagttcagat ggaaaacacc tatcagttgg gtcctcccaa acattttcct361 gtggtcaccg tcaatcatat tttgaaagat gtagtaacca gctatctaca agtagaagaa421 tatgaaccag agctctgtag acagatgact aaaaccattt ctgaggttat taaagcccag481 gtcaaggact tgatgattcc acggtataaa ctaattgtga ttgttcacat tggacaactg
541 aacaggcaga gcataattat tggaagcaga tgcctctggg atcctaaaag tgataccttt601 tcatcttatg ttttcagaaa ttcttctctc ttcgctcttg caaatgtcta tgcagtttac661 cttgagtgat tgaaaataag aaatctagct cttacttttg aaaattctga ggcaggctgt721 atgtctgtac acaaaagttt tactgccaaa aactttgaga aagaaacaac actgatattt781 caaacaactg gaagcttttg aattttttca tattctagta aagatttggg gaggggaggg841 tagccacaga aagaatcttg tttatctaaa gcaggaactt gatcttggtt ttgctggatt901 gctttccata gacatagatt cttattaaat atttgttttg gtactaatta ttttaattat961 tctttaatta gagtgttaca atttcctgca ttgtttttta ataaaaagaa gctttagaaa1021 aactatggct atataccctg accaataaat gatagtagaa tattcaacat ggtatacaca1081 aatgataaat aatgtgcctc agtgctgcat ataaaagaat actggttttc attttgtact1141 taataaattg agcagcattc attaagtgca attattgtta catgtacctg acagttgaaa1201 ctgctgaggt agaattaatg gcttcataac aattatcgtg gtcccacggg ctgcaagcta1261 aaactagaag ctcttgtggc ttgcctgcac tttacacaat tgtgggagaa ccgaaagttg1321 gctcttcagt aatggaaact ataaagtgaa taaaggcttt ttgggacact gaagtagaca1381 ttgtgatatt aaatatacat gatgcttaat actaaatgtg tctgtaacac ataaaatcat1441 ttattggaaa gagacattgc ttttaaatat cctaggctaa caaacttttt cacaaaatat1501 atggctggca ccttaacaaa taaagcatgt gtagttacca ttttactcct atgaatttaa1561 tactaaagtg acccagtgag gtttttgaat agacgggtgc taaaatttac agggctgaaa1621 tagcttatta ttctgctggt taatgtatct tacgccacgg atcatttatt tttatgaagc1681 tttcaagtct ttgtgtgcaa gtaaaatgat gttgtggcgt tgttcttgga tggtaagtgg1741 actgcctaga ggacatttgt taaaggtcaa agactaattg tacacatatg gagaaaatta1801 gcaatgctgt agtcttaagg aaaaaatgat ttatcattca tatcaaaaag agtttagcaa1861 atggaaaacc agttaatgct ttaattttaa aatgttttgg tgtcttactt ttccctaaaa1921 atgacatgta gtaaaaaatg gatactttta aaatcccttc ccttctgcta ttttctggct1981 tttaaagtga ttattcaaaa tg<210>13<211>1640<212>DNA<213>Homo sapiens<400>131 aaggatgcag caggggcagc tggcacctgg gtctaggctt tgctcagggc cctggggcct61 ccccgagctc caacccgctg cgccctcctc atcagccgct cagctgccct ggggcgagag121 ctggggggaa gaagcagaca ctcctgcatg tctttctgct tctggggtgt ggttccagaa181 ccgcaggacc aagtggcgga agaagagcgc cctggagccc tcgtcctcca cgccccgggc241 cccgggcggc gcgggtgcag gcgcaggcgg ggaccgcgca ccctcggaga acgaggacga301 cgagtacaac aagccgctgg accccgactc ggacgacgag aagatccgcc tgctgctgcg361 caagcaccgc gccgccttct cggtgctcag cctgggagcg cacagcgtct gacgcccgcc421 gtccaggccc gggatcctgg ctgcagcctg cggggggacg ccgaggagcc taccttcccc481 tccccttccc cacgctcctg ggggcgcagg gactgagtct ttctttggat gaggggcgcg541 tggaggagga ggaaaaggag ggaaagggga caggcatcct agctaaggga ggaggaggcc601 aggagggagg cacagcactc ctgagacctg gaagccgctg ccccttgcac ctcctcgggc
661 ctcgcctgcc agttctgcag attcacaagt ggacagagga ctaaaatgac caggctctgc721 agccaagaaa ctggctgtgg ggtcccagac atgccactgt gatccagctg ttggggcggg781 gggagtgggc aggacttccc agggagggag gcagctggct ggggagtcag aagtccagag841 tcttgggccc caagccagct gctggctgca gaagaaaaga caggtgagtg gccaggtgca901 ctcctcagac ctgtgcacag gaagggtccc actggagggg ccagagctga gcacctaacc961 caggctgcag gaaatctgcc tccaggaggg gaagtgggac ttcccagtgg agaaaaaatg1021 cccctgacac tgcaggatga cggtccctga gctgcggaaa tccccctggc ctcctttctc1081 cgatttaccc tcagggtcaa tacctctgag accgctgtgc cctcctcatc ctgacagccg1141 gggaaaaggg gagggtgcag ggagagggga ggcggggacg gtgtgcccaa gggccaccca1201 cctgggcatc atttggtgct gatataagga caggcccacc cagagagaaa aagcatccca1261 cctggggagg aaaggaaggg ctgggaaaga ccccagaacg gcacccctcc aacaaggcag1321 gaagggagaa ggacagcccc tccggctggg tggaggatgc caggaagggg ctgaaccacg1381 gcctgctggg aatcacggcc cttcctttcc tcagatcgcc ttgcggcctg gcactggagc1441 tggtgctgac agggacgctg gccaacaggg tggtattttt cacccgggtg atctgagctg1501 ctggcaggta gggggtgggc tgggggaggc gggtgagggc tggtcttaga taggaatgca1561 gcccagaagg gaccaagcac ttgcccatcc tcactggctt tcaaaaaata aacagtaaaa1621 ataaaagtcc catgaacctt<210>14<211>1219<212>DNA<213>Homo sapiens<400>141 gatgcttttt aaactttttt ttactaccct gtggtccctg aggagcatta cactgagaag61 ttttctccta ttttgtcttt cattctccac atcctctttt gttctagtgc atggcatggg121 aagccctctc taggaggatg ctgtggccac acaagtgctg gacgaaccgc tggagtaggt181 gacttccaag gtgtcctgat gtagtagcta ttagacaagc tcctgcattt ggccagtaat241 tagcatgctg ctgcacattg ccactaggtg gtgctgctgc tccattccca agtaacccac301 atgcatccct ggctggggtc agccttgggg tttcccaagt gtagaggaat ccatctctgt361 gcctgtggta atggctggac accaggagag accctgtctc aaaacaaaac agaaataaca421 aaaaataagg tgacttgctg gaggccacat ggctgtgagc caaatacagg tctgggttat481 cagggctcac atacttctaa gtacacccta ctgccttgga atctgctgaa gaccaagccc541 ctgcccccaa gccatggcaa agaaggaggg aaggaagcaa aggtgcccag cggggacaac601 tcggggaggg gcgaggtgcc cagggcccag gaaggccaag cagcatgtgg cagggcagca661 tcaggtgact cccaagaagg aatgaggaga ggatatgagg aaagagccac agcacagagg721 cctgctgtta ggtcagcgga gaccacggcc catgggacct ggatctaccc ttgatgctaa781 caatgttctt tggggaaaaa atctataatc acaaagtttc tgcaactgga ctgtagtcat841 ggttgcagaa ctgtatagat ttactaggaa ccatcaaatt gttcacttac aatgggtaaa901 ttgtacagta cataggttat ccctcagtaa agctgtatga aatttatagt catgaaacta961 atagtgacaa acgagctggg taagtaggtc tcagctgttc tgtaggcact ttgagaagag1021 gaagagtagc atctcggttt taataaaaga aagcctggcc catggcgtcc agcttctgct
1081 tgaatacttt cagtgcccgg gagctcagta tctcaaagca gcccactcct gtttaagaga1141 actctaaacc ttagaatgtt gaaatacatc attattattc tagtactgct gtgaaaaata1201 aatgtctttg ttttgccac<210>15<211>1969<212>DNA<213>Homo sapiens<400>151 aggttccctg agagctaccg gccaggggtc gggaggctat gggagctcag ggcaggcacc61 tcccatgctc ccgcgggagc caccaggaca tgaaggcctc aggagccggg acactccctg121 agtcctctgg gagcccttaa gccacactga gaacacagac cctgggagaa gcagccagca181 gtgaggaatc ctggaacccc ttcccaggga gagccttccc atgaccccca tgaagagatc241 agtgcaaaca caggtgtcag agcccttcat ggagtcctgg ggtgaggagt ccctgccgga301 gctacccgca gagcagtccc tgacggagta ctctgacctc gaggaggctc cctcggcgca361 cactctctat gtgggccatc tgaaccccca gttctcagtg ccggtgcttg cctgcctgct421 gcgagacacc ctggagcggc tggagatgcc ggtggcgcgg gagcacattg aagtggtgag481 gcggccgcgg aaggcctatg cactggtgca ggtgactgtc cacagggaca ccctggcctc541 cctcccctgg cgcctgcaga cggccctgga ggagcaccta atcctcaagg agctggcagc601 cagtgggaag gacctgctat tgagtgaggc ccaagggccc ttcagccaca gagaggagaa661 ggaggaggag gaggaggaca gtggcctgag ccctggcccc agtccaggct ctggtgtccc721 gctgcccacc tggcctacac acacgctgcc tgataggccc caggcccagc agctgcagag781 ctgccagggc cggcccagcg gcgtgtgctc cgacagtgcc attgtgcacc agcagatcgt841 gggcaaggac cagctcttcc agggtgcctt cctgggcagc gagacccgca atatggagtt901 caagcggggt agcggcgagt acctcagcct ggccttcaag caccacgtgc ggcgctacgt961 gtgcgccttc ctcaacagcg agggcggcag cctgctcgtg ggagtagagg acagcggcct1021 ggtgcagggc atccgctgca gccaccgtga cgaggaccgc gcacgcctgc tggtggactc1081 catcctgcag ggcttcaagc ctcagatctt tcccgatgcc tacactctca ccttcatccc1141 tgtgatcagt acctcggaga ccagcgtccc cctcaaggtg atccgcctga ccgtgcacac1201 ccccaaggcc cagagccagc cgcaactcta ccagacagac cagggggagg tgtttctgcg1261 gcgcgacggg agcatccagg gcccgctgtc tgccagcgcc atccaggagt ggtgcaggca1321 gaggtggctg gtggagctgg gcaagctgga agagaagatg aaggcgctga tgatggagaa1381 ggagcagctc cagcagcagc tgcagcagca cgggcctgtg tcctgcacct gctgtgtcct1441 gtgagggccc tggggagcag gcaggacggc acggcactct ccacctgaga cccagggatt1501 tcctgtttga gtgtaaggcc aaccagtaaa gcccatgcgg gctgctgaga ggcggacagg1561 gactccttca acatggcaca tgagcaggca cccatgtggc ttcaaccctg acagacccat1621 ctgtgtagcc aagaaactgc tctcagccct gtccccaaat gaccttactt tcagaaagaa1681 tgtgtaaaac cctgcccaga gctcccctag ggctaagcta taagggattg tccttctccc1741 taaaatgctc atttggccca ggctgaggtc tgtgactcca gttggctaca cagtgccaga1801 aaggaatctg tcatctcagg aaagcccctc aaagatggcg aggcatattt gatgactgtg1861 gttacagggc aagaggccac cctgcagccc ccacccctga cttgctggaa cttgtgactg1921 tcaaagctcc attaataaat tacatgcacc tggaaaaaaa aaaaaaaaa
<210>16<211>2097<212>DNA<213>Homo sapiens<400>161 gaaaaaaacg ttgctgatta gagctgccgg gtcagaaaca gctgtgagac actaaagtcc61 ccactgttat aattattcaa tatgttccca ctgactgagg aaaacaagca tgtggcccag121 ttgttgctca atactggtac ttgtccaaga tgtatcttca gattctgtgg tgtggatttt181 catgcacctt acaaacttcc atacaaggag ttgctcaatg aactacagaa atttctggaa241 actgaaaaag atgaattaat tttggaagtt atgaacccac ctcccaagaa aattcgactg301 caagaactgg aagatagtat tgataatcta agtcaaaatg gagagggaag gatctctgtt361 agtcatgttg gaagcactgc ttccaagaac tcaaatttaa atgtatgtaa tgtatgccta421 ggaattcttc aagaattctg tgagaaagat ttcattaaaa aggtgtgcca aaaggttgag481 gcctctgggt ttgaattcac cagcttggta ttttcagtct ccttcccacc acaactatct541 gtaagagagc atgctgcatg gttgctggta aaacaggaaa tgggaaagca gagtctgtcg601 ctgggaagag atgatatagt tcagctaaaa gaagcctaca aatggataac tcaccccctg661 ttttcagagg aactgggtgt tcccattgat ggaaagagct tgcttgaagt gagtgtggtc721 tttgctcacc cagaaacagt tgaggattgc cacttcctag ctgcgatatg cccagattgt781 tttaagccag ccaaaaacaa acagtctgta ttcactagaa tggcagttat gaaagccttg841 aataagataa aggaagagga tttccttaag cagtttcctt gtcctccaaa ctcaccaaag901 gctgtatgcg ctgttcttga aattgaatgt gctcatggtg ctgtttttgt ggctgggaga961 tataataaat actccaggaa tctaccacaa actccttgga taattgatgg agaaaggaag1021 ctggaatctt cagtggaaga attaatttca gatcatctgt tggcagtatt taaagcagag1081 agttttaatt tttcatcctc tggaagagaa gatgtagatg tgagaacatt aggaaatgga1141 aggccctttg caattgagct ggtgaatcct catagagtac atttcacttc acaagaaatt1201 aaggaacttc agcagaaaat taataactca tctaacaaaa tccaagtacg tgacttgcag1261 cttgtcacaa gagaggcaat aggacatatg aaagaaggtg aagaagaaaa gacaaagacc1321 tacagtgcct taatttggac aaataaagcg atacagaaga aagacattga attcctaaat1381 gacataaagg acttaaagat cgaccagaaa acacctttgc gcgtccttca ccgaaggccc1441 ctggctgtgc gagctcgcgt cattcacttc atggagacac agtacgtgga tgagcaccac1501 ttccgcctcc acttgaaaac tcaggctggc acctacatta aagagtttgt acatggagac1561 ttcgggagaa ccaagccaaa cattgggtcc ctgatgaatg tgactgcaga cattctggag1621 ctggatgttg agtctgtaga tgttgactgg ccacctgctc tggatgacta gctttcaaat1681 ttggagacaa agagtatggt tttcctggca tgatgtggac atccatggag cacatgccgt1741 aaaatggctg tttacccacc ataacggtgt cttgaaaact atttggatca tgttgatcta1801 tataattgtt aatttgttgt aacatctcag gatctatata tgtgtatatt ttgtgttaaa1861 ttgttccaag gatgtcttag gatttttctc attccctctt tcacccccac aaaccaaact1921 atgaataatg aaataattct ccttaattct ttcatttaga gaggtgcaca aacaggacac1981 attctctgtt aacctaagaa gctgtaattt cagcaagatt tccctccaca agagatatac2041 cacctttaaa atcatgttct aatttttgta aattatctga ataaaagtta tatctag
<210>17<211>1990<212>DNA<213>Homo sapiens<400>171 aggcggtgct gcagggctgg tccgggaggt gacgaccggc ttcggagagt ctatcatggc61 agctcggact ggtcatacgg ccttgagaag ggtagtctcg ggatgccgtc cgaagtcggc121 gacagcggcc ggggcgcagg cgcccgtgcg gaatggcaga tatttagctt cctgtggtat181 actgatgagc agaactcttc cactacatac ctcaattttg cctaaggaga tatgtgcacg241 aactttcttc aaaatcactg caccattaat aaacaaaagg aaagaatatt cagagagaag301 aattttagga tattcaatgc aggaaatgta tgatgtagta tcgggagtgg aggattacaa361 gcattttgtt ccttggtgca aaaaatcaga tgttatatca aagagatctg gatattgtaa421 aacaagatta gaaattggat ttccacctgt gttggagcga tatacatcag tagtaacctt481 ggtgaaacct catttagtaa aggcatcttg tactgatggg agacttttca atcatttgga541 gactatttgg cgttttagcc caggtcttcc tggctaccca agaacttgta ccttggattt601 ttcaatttct tttgaatttc gatcacttct acattcccag cttgccacac tcttttttga661 tgaagttgtg aagcagatgg tagctgcctt tgaaagaaga gcatgtaagc tgtatggtcc721 agaaacaaat atacctcggg agttaatgct tcatgaagtc catcacacat aaaggcaaaa781 aagaactggt gccacctgct tctgacttta gtttgttcac ttttaggaag tattttcatg841 acatgttttc agaagccaga aagcatttgt taaacgcagc tttggttata aacctgcacc901 attgaaaatt tgcacataga atatagactc acttgtacat agaattattt cttcaagtat961 aattcaaaat aatatggaca ttatcatgtt ctgcattaca ataatgggat gtcatcacca1021 ttgctagaat actggcatga ttcttctgag cagaagttga aactgtaaat ttaaaccttt1081 taattatcac cttacctgaa agaggttagt taagatattc acacagtatg tattatatta1141 accatatcac acttaagtta ttaaattcag actatttgta acttattgtt atagggcctg1201 ccgtatggct taggatattt gagtaatcat atatttaaag taaaaacttt gggctgggca1261 cagtggctca cacctgtaat cccagcactt ggggaagctg aggtgggcag atcagttgag1321 gtcaggagtt ctagaccagc ctggtcaaca tggcgaaacc ccatctctac taaaaataca1381 aaaattagct gggcgtggtg gcacacacct gtaatcccag ttacttggga ggctgaggca1441 caagaatcgc ttgaacccgg gaggcggagg ttgcagttag ccaagatcgc cctgctgcac1501 tccagcctgg gcaacagagg gagactctgt ctccaaaaac aaaaacaaaa actgttagtg1561 aaggttccct gggacttttg atattttaaa aattgttctt atgactagta gataaattca1621 ttgccataat gaggctagct cccagataaa cagtgtattt tcttcttttt tttttttttt1681 ttggtgagtg gtccagagct ttaagctact tttccagtag tttgccactt tctccgaggt1741 agtttggctg ctctttcagt aatgctaatt gtgtgtcaaa ttttgtctac aacagtaggc1801 aacagatgaa gataagttgg ttgaatgtct ccagcactat gcatccctat tttctattta1861 ttgtgtacac tcactttcag taatgtgttt caaactggta ttttttaaaa aacaaatcaa1921 tgtaaggact gaagttgaag tagcaatgta ataaagttaa tttgtttatt ttttgaaaaa1981 aaaaaaaaaa<210>18
<211>1814<212>DNA<213>Homo sapiens<400>181 atgggccacg ggcccccacc gccgcccgcc gggaggaccg agcctaagag ggcagccgcc61 tgaaggaacg cgacggcggc gcccgcagta tttttcagtg ctgtacaagc gtcttgaatt121 actctggtag cttttccaga aagacccatg acttcaccac atttctcgag ttacgatgaa181 ggtcctctgg atgtcagcat ggcagccaca aacctggaga accagctgca cagcgcacag241 aagaacctcc tgttccttca gcgggagcat gccagcacgc tcaaggggct gcactccgag301 atcaggcggc tgcagcagca ctgcacagat ttaacatatg agctgacagt caaaagttcg361 gaacagacag gagacgggac ttctaaaagc agtgaattaa agaaaagatg tgaagagctg421 gaagcccaac tgaaagtgaa agagaacgaa aatgctgagt tgttgaaaga actggagcag481 aaaaacgcga tgatcacagt gctggagaac accatcaagg agcgagagaa gaagtacctg541 gaggagctga aggccaagag tcacaagctg accctgctgt ctagcgagct ggagcagcgg601 gccagcacca tcgcctacct gacctcccag ctgcacgccg ccaagaagaa gctcatgagc661 tccagcggga cctcagatgc cagcccgtca gggagccccg tgctggccag ctacaagcca721 gcgcccccca aagacaagct acccgaaacg cctcgccgcc gcatgaaaaa gagcctctca781 gcccccttgc acccggaatt tgaagaggtc tacagattcg gggcagagag caggaaactc841 cttttgcggg aaccagtgga tgctatgccc gaccccaccc catttctgct ggctagggag901 tccgccgagg tccacctcat caaagagagg cccctcgtca tcccccccat cgcctccgac961 cgaagcggcg agcagcacag cccggcccgc gaaaagccgc acaaggccca cgtcggggtg1021 gcacatcgga tccaccacgc caccccgccg caggcccagc ccgaggtgaa gaccctggcg1081 gtcgaccagg tgaacggagg caaggtggtg aggaagcact cagggacgga cagaactgtg1141 tgaagcccgc cgtgccccac cccgcgctgt ccatgcactg tgagcaccac tgggaaatct1201 cagccacacc ttttctgttt aatcccatgc atgccaaaca cttttcacac ctaccgaccc1261 attctccttc tgcttctctt gccctcttct tcacaccaaa atatgatcgt gtccctgccg1321 cagaatatgt atttcctaat tgctgtggcc aagcgcctgt gtgccgaatc gcttgcttct1381 gatcccgctc cgtgtaacct aagtgcgctg caggcaaagc ccaggccacg gctgcgtcac1441 tactgatgtt cacgatgcca cacagtcaca cacctaattc attctcaagt cggagcaaca1501 cataccaacc ttgaccttat cctcaagctc cagggcagcc tggccgagca gcccctgctc1561 cctcctggag acccttgtca cctcccgagc tcctcctgga gacccctgtc acctcctgac1621 caacctttcc cagggcggca ccgatcaccg agcagccgtg cgtgtatctc aaggaactaa1681 ataagatgac gctactcctc atagcaccac aacctgaatg tgtgttcata tttttttgtt1741 agttttatcc aaaatgttta agatcccaac aaactttatt ttctaaacct gccaaaaaaa1801 aaaaaaaaaa aaaa<210>19<211>1921<212>DNA<213>Homo sapiens<400>19
1 ctgtatggcc acaccctcac ccctgagcag cccggggggc cacagcaaga ggtacacatg61 ctgtggacac cagcaccccc agacctgacc cttggggaag gtgaggaggc taggacgtgg121 gacttcctga cagcagtggg cggcagccag gctgaggctc aggcctgcct cactgaggcc181 ctgcagctgc aggccagggg agctctgtat acggctcacg cacaggcctg ggcccagctc241 tgggtagaat gtggcttgga cgtggtgggg cccctgcagc tgcgccaggc cctgcgtggc301 tccctctact acctgctcag tgccctgccc cagcccaagg ccccaggata catctgccat361 ggcctcagtc ctgggggcct ctccaatggg agccgtgagg aatgctactg gggccacgtc421 ttctgggacc aggacctctg gatgttcccg agtatcctga tgttccaccc agaagccgcc481 agggccatcc tggagtaccg catccgcacg ctggacgggg ccctggagaa cgcccagaac541 ctgggctacc agggagccaa gtttgcctgg gagagtgcag actccggcct agaggtttgc601 cctgaggaca tttacggagt ccaggaggtc cacgtcaacg gggccgtggt gttggccttc661 gagctgtact accataccac ccaggacctg cagctatttc gagaggctgg tggctgggac721 gtggtcaggg ctgtggccga gttttggtgc agtcgtgttg agtggagccc cagggaggaa781 aagtaccacc tgaggggagt catgtccccc gacgagtacc actcaggggt caacaactct841 gtgtacacca acgtcctggt ccagaacagc ctgcgctttg ctgctgccct ggcccaggac901 ctgggtcttc ccatccccag ccagtggctg gcggtggctg acaagatcaa ggtacccttt961 gacgtggagc agaacttcca cccgaagttc cagctccgag ttccctggga ggactttttc1021 agatgttagg gacccgctcc agagccccct ctgggtcacc ctgggttcct ccagccaggc1081 tctcagggaa ggtccatgct gcttggcctg agttcaaggc tttctgcctg tagcctggac1141 tcccgtggac ccccgtgggc aggtggcttc cccgtggcat ctccacaccg cctctgcctg1201 cccctgtgga ctgatgctat cgcgcacggt cccacgaccc caccccgagc tcctgaagcc1261 ggggtctgag cctgcatcac ctctggcctc tcatccccca ctctcctgag agcagtggtc1321 acagcggccg gccgctctgc tgagaaggca gagaggcagg ctcaggcctc agcgtggaca1381 gcagggataa ggggcacgaa ggacggggac tcggcccctt cagaattcct caggactctc1441 aggtgcagct ttgccaaaaa ggaacttttc atgtcatgca gttgagggga cttagtctca1501 atcccaggct cctcttgact ctgggcagct ttaatcaggt tgggcagcct ctgctacagc1561 gtggagtggg atggctctct tccctcagcc acgccgcttg tgaggacaga ggtgggggag1621 tgggaagtgg gaagtcacca gagaacagga gagggatttg agggcgagac cccagcgctc1681 tccacggacc agccagaggg actggagcca ggtgtgcatg ggtccaaggc cctggccctg1741 cccagcctct gtcttgggag ctcagcccca gggttcggtc gtcagcagtt tcccaagaac1801 aagatgtgat ggcatctgct gctgaaaccc tgatgaggac caggccccct gcaccgctgt1861 cagcctgagg aattaaagct ttggtgctgg gaagagcaaa aaaaaaaaaa aaaaaaaaaa1921 a<210>20<211>2052<212>DNA<213>Homo sapiens<400>201 aatcgacccc tggaagccaa gaccgcatca caaaactgcc taggaagagg aatggaacaa61 gtagcaaaga agttaggggt ggctcatgaa gagattcaaa ggctcactga tgagctacaa121 gtgaaggaga aggaacaatg taaattagat tctgcactta agaaggctca actagaaatt
181 gacaaattga aggaaaattt ggtaaagctg aaagaaaatg atgcagctga cctacagaaa241 gcaaaggaac aaaatcagag actggatgag gaaattctgg ctttaagaaa tagggttcga301 tcacttgact cagaaaaaaa ggtgcttggt gaaatggttg aaagacttaa aggagaggtg361 tgtgaatctc aagagaataa gcaacttgga aaccactccc ctggaaaaac tgtgggtggt421 gaacagagag aacagattga ggcttccatg ttagagcctg aattatcagt aacataggaa481 gatagaagag aaaccagtac aaaagatcaa gagacaaagt acaagatttg aatgagatcc541 tgaaaatgag ccaagaaaaa aatgaaatgt ttgaaagtga gtggtcaaaa gagagagaga601 gagagaagca gttggcatct ggtcttgaca ctgcagagaa ggccttgaaa gttgaaagtg661 aggtattacc attcaggaag ctgttttctt cttcttgtag ttctaattta gggatttcat721 gttatcattt ttaaataaag tataactatg tgtctcagct tgggctgcca taaccaaaca781 ccacagacta ggtgtctcaa agaacagaat tttattttct cacagttatg gaggagggga841 agtccaagat caaggtgcca gccaagtcag ttcctggtga gggttctctt cctggcttgc901 agatggccac cttcttgctg tgtcctcaca tgacagagtg agcaagctct ggtgtctctt961 cctcttccta taaaggcact aaccctattg gattaaggcc ccacccttat atcctcattt1021 gacctttatc acctccttat caaccctatc tatctccaaa tacagtccat attgggaatt1081 agggtttcaa caatatgaat agggagggag agcacaattc agtccatagc actgtagaat1141 acgtgtttct ataataataa tggggtagct ctgttgtttc tccaagctga gttctagcac1201 taagcaaaga gtcctttatt tagcagacgt ttgattgttg tagtgttcat agagtcatgg1261 gcttatcgct cgttttaact tcttgtcctg ccatcttgga aagatctatc aggagacata1321 atcagcctat attatgaaaa gagacctgga agtgagttca tggaagtcta aatcagtaat1381 ttagaggata gtgacactca atcagtttgt agtttgcagt gcccctaatc tcatcctaat1441 gacctacagg aattttcagt gaaataagat aggaaatcaa ttatcattta ccctcttcct1501 gtggttttgg gaggccaccc tctaccttct tgcctttttg tctaagcctt tctaatcagc1561 atttacctcc cactttgact tcaaggcttt gggaaaatac caagtagctc ctctcctgaa1621 gtaaatttta tgtaacctat tcccttcatt gagcaccaca gactgactct caacccaaag1681 tcttccacca gccaatcagt gcacatcctg tgtcatcaat gtaaaaatct gttaaaaatc1741 tgcatttagg ttgggcacgg tggctcacgc ttgtaatccc agcactttgg gaggccaagg1801 tgggcggatc acctgaggtc aggagttcga gaccagcctg accaacatgg agaaacccca1861 tctctcccga aaatacaaaa ttagccaggc gtggtggtgc atgcctataa tcccaggtac1921 ttgggaggct gaggcaggag aatcacttga acccaggagg cagagattgc agtgagctga1981 gatcatgcca ttgcactcca gcctgggcaa caagagaaga aactccatct caaaaaaaaa2041 aaaaaaaaaa aa<210>21<211>2057<212>DNA<213>Homo sapiens<400>211 tagaaacaga cccacactgg ccaccgcacc agattcaagg catttgttac tgttagggac61 tatgatggcc acatcagttt aagtgttaag tgctccaagg aggttactac tgccatccaa121 gggaccatca ccctggccaa gctttccatt gtccctatgc ggagaggtta ctgggggaac181 aagatcggca agtcctacac caccccctgt atggttacag gctgctgtag ctctgggcta
241 gtacacctta tccctgcccc caggaacaat ggcatcatct cgactcctgt gcccaagatg301 ctgctgctga tggccggtat tgacaactgc tacacctcag ccaggggctg cactgccgcc361 ctggacaact tcaccaaggc caccttcaat gccatctcca ggacctatag ctgcctgacc421 cccagcctct ggaaagagac tattcaccaa gcctccctgt ggaatgcact gaccatcaca481 tcaagaccca caccagagcc tccatgcaga ggacccaggc tccagctgtg gttacagcat541 aagctttcat acaagaataa tagtgaatta cacctgttaa aaataataag cagaagaaaa601 tgaaattgaa caaaccagcc accgtagtcc cttctaaagc gacgtggtct gcgggcatca661 gtgcccttcc tctctggcta tagctcttcg gcatctgaag aaagttatcc taactattgg721 gtgatccaga tttgggcact gtctgctatg atgatgccag ctggtcggga aggaatataa781 agtataggct caacccttcc acagtcactg tactgggaat tcaggctttt cctctctgtt841 gatgtcaaga attaacctgt agataacatt cttttttttt tctttttttt ttttttcaat901 ttttccttgt tcttgtcaaa ggctgtgtcg cttaaaacca aatcttgata gattcttcat961 ctttatcact ctctatgaga agtaaatatg atttaagtga accacagtga gaggcctgtc1021 ctcactacag caaataagat gtgtcccagg tgacaagtcc agtctccttt taacatggtg1081 cccagaattc cacatacctg agctttgggg gctgatacaa agccactgcc tctgatccca1141 cggaatgacc tgaatttact atcagttttg ccacaatcag tgcagtttga ggatacgtag1201 acccctgaga tgaggcctga gatagatgtt ctgggaaacc ccaaggaagc taaagtacct1261 gccatggttt ctttcatggc aggttgagta agccaagctc ctgagaatga ttggtcacat1321 tgtctttgct gttaaggttt cttggtttac agatggtgaa gttgcagaca agttagcaaa1381 ccaactgaat tttaataaag gaagctttag gaaaatggat gaagatgcag ttggaaaatt1441 aaagtcatgc ttccttgata catacctcaa ttctggcaac ttctcacttg gaattttcca1501 aagtcagttt ttggtaatct tgccatttgt attatcttta tttatatagt tctggttatg1561 cttggtgtgt gccagctgtt ttgggagtga tgtttttcct tatttctctt ggctcctgtt1621 aagtgttaag ttgctgaaac tgacctttaa tgcttccaaa gcaatcagca tctttctctc1681 tggatggctt ttagaagtgg acacagttta ctgatttagc cagtgaagag aaagctttcc1741 atagtgtggt ttactcagag caggtgacaa aaggatgaat ttctggctgg gcccagtggc1801 tcacgcctat aatcccagca ctttaggagg ccaaggtggg caatcatttg aggtcaggag1861 tttgagacca gcctggccaa catggcaaaa ccctatctct actaaaaata caaaaattaa1921 ccaggtgtgg tgacaggcac atgtagctac tcaggaggct gagacaagaa tcacttgaac1981 ccgggaggca aaggttgcgg taagctgcga gcatgccact gtactccagc ctgagctaca2041 gagcaagact ctgcctc<210>22<211>1975<212>DNA<213>Homo sapiens<400>221 actggtgctg caagtcgctg agctgacagt tgtgccgagg actgtcacca ttgggcaggc61 atggtggcca gctcctcact tggctgaggt ccagggatgg acacaggtcc gctgaacgcg121 gccagcctga gggaggagca gctccacctg tccttgctgg tgtccagcgg ctggagaaca181 atcagcttcc acgtggtgcc cgtggtgaga aggaagcttg gggcgcctgc cctggagggg
241 gtgcagcaga tgcccggatt ccctgagggc agcttgagaa gaatcctcag ccaaggggtg301 gacctggtgc cggccagtgc ccagctctgg aggacctcca ctgactacct gctcacgagg361 ctgctggggg agctgggctc cctgcagggt catcgcctgg acagcctctc catcctcgac421 cgggtcaacc acgagagctg gcgtgacagt ggccagactg acggcctgac ctttggccac481 ctgaagatgg tgctgctgtg ggcctctgtg ctcttcccgg cgcccgagga ctgggcagag541 ccgcagggcg ccgtgtaccg cctgctggtg gtgctgctct gttgcctggc cacgcggaag601 ctgccccact tcctccaccc gcagcgcaac ctgctgcagg gcagcggcct ggaccttggt661 gccatctacc agcgcgtgga gggcttcgcc agccagcccg aggcggccct gcgcatccac721 gccacccacc tgggccgcag ccccccgccg cgcatcggct ccgggctcaa ggcgctcctg781 cagctgccag ccagtgaccc cacttactgg gccactgcct acttcgacgt cctgctggac841 aagttccagg tcttcaacat ccaggataag gaccggatct ctgccatgca gagcatcttc901 cagaagacca ggactctggg aggcgaggag agctgagctg ggccacctgg tctcagccac961 ctgttcttgg ctccccaaca gactctgcac tgcaccatgg gaggctcctg ggatgtttgg1021 aagaagaaac gggcttctcc ttgagggggt agtggaggga ttttgtcccc agcagtggcc1081 tctgagagtc tttcagtgcc tggtggggca gggcaggcct cttggagcac ctcctccctg1141 ggtcagggcc tggatgcagg tgccaagctc tccatgtggt gcatgttgac ccagccacgt1201 ggtgttgtca agcaaacagc atcggcagga gacctggagc tgaggacttg gccctgcctg1261 cactgtatgc cattccttgg tgatgaaatg ctgtatattt ggttttgaaa aaatgaatgt1321 gctgggtata cacagcagaa agggtactgt ccactttttg tatatcagtg tgaaaaatat1381 ttcccctaga agtagaaaag gctcatgtgc tgatggataa ttttgagtct tctccattct1441 ctgtgaatga cccccttccc caggcatccc cacctcctac ctcgttctta gagcaaacta1501 aagccaactg agggtgcaca cacagccatg agcccacctg cccaggacta ctcccatctg1561 cttcttcccg tccccgtgga agtggcccct gatatggatt gtatctgtat ccccacccaa1621 atctcaggta gaattggatc tgtgtcccca cccaagtctc aggtagactt gtaatcccca1681 gtgttggagg aggggcccag tgggaggtga ttggatcatg ggggtggatt tctcccttac1741 tgttctcatg atagtgagtg agttctcatg agatctggtt ttttgagtgt gtggcccctc1801 cccctctcct tttgctctct tcctctttct ccggccatgt aagatatgcc tccttctcct1861 tcaccttcca ccatgattgt cagtttcctg aggcctccca gccatgcttc ctgtatagcc1921 tgcgggactg tgagtcaatt aaacctcttt attcattaaa aaaaaaaaaa aaaaa<210>23<211>1999<212>DNA<213>Homo sapiens<400>231 acgcgctctt agaccatggc gacccaggcg aagcgtccac gggtggcggg gcccgtggac61 ggcggcgacc tggatcctgt ggcctgcttc ctgagctggt gccggcgggt ggggctggag121 ctgagtccca aggtggcggt cagccggcag ggcacggtgg ccggctacgg catggtggcc181 cgggagagcg tgcaggccgg agagctgctg ttcgtggtgc cgcgggccgc gctcctgtcg241 cagcacacct gctccatcgg cggcctgctg gagcgagagc gagttgcgct gcagggccag301 tcgggctggg tgccactgct gctggcgctg ctccacgagc tgcaggcccc ggcctcacgc
361 tggaggccct actttgcgct ctggcccgag ctgggccgct tggagcaccc gatgttctgg421 ccagaggagg agcgccggtg cctgctccag ggcacaggcg tacctgaggc cgtggagaag481 gatttggcca acatccgcag cgagtaccag tccatcgtgc tgcccttcat ggaagcccac541 cccgatctct tcagcctcag ggttcgctcc ctagaactct accaccagct ggtggccctt601 gtgatggcct atagctttca ggtaccactg gaggaagaag aggatgaaaa ggagcccaac661 tcccccgtga tggtgcctgc tgcagacata ctaaaccact tagccaatca caacgccaat721 ctagaatact ctgcgaattg tcttcggatg gtagccactc agcccattcc taaaggccat781 gagattttca acacttatgg gcaaatggct aactggcaac tgattcatat gtacggtttt841 gttgaaccat atcctgacaa cacagatgac acagctgaca ttcagatggt gacagttcgt901 gaggcagcat tacagggaac aaaaactgaa gctgaaaggc acctagtgta cgagcgctgg961 gatttcctat gcaaactgga gatggtaggg gaagagggag cctttgtgat agggagggag1021 gaggtgctga ctgaagagga gctgaccacc acactaaagg tactgtgcat gcctgctgag1081 gagttcagag agcttaaaga ccaggatgga gggggagatg ataaaaggga agagggcagc1141 ctgacgatca caaatattcc caagctcaaa gcatcgtgga gacagctgct tcaaaacagt1201 gttctactga ctttgcagac ctatgccaca gacttaaaaa ctgaccaagg tttactcagt1261 aataaggaag tctatgcgaa actcagctgg agggaacagc aagccttaca ggttcgctat1321 ggtcagaaga tgatcttaca tcagttgttg gaactgacaa gttagcagtt tccctgttcc1381 ctgaaggaac agcaataaga actttattct aagctaatac tcattgatgt ttgaaaaaga1441 ggaaaatttg gatctttctt ttgcttacta aacaccaaga ggaaaagtag caaagttggt1501 gtgctaggat taactcaggt aagggtgatg tgttttagga ttgagaacag cagacttggg1561 aatcactgct aattgttact taaagcatgt tacagctgtt ttgttctcag ttttaaccaa1621 agccagtgga catacggtag taataactaa gtcttgttgt gtttcagcat ttaataatag1681 actttggagg tagacccctg gtttaaatct aagtctagtt tgaggaagtc acttaacctt1741 tattgaaaag actctggatt taataagctg tgtaactggt actcgatagt tacccaaagt1801 tcagtctaga tggcacaaac cacctctcag ggaataaacc ctaagacatc actcaaggag1861 gacttcaatt atttaatttt gaactgtttt gtcctctctg gccataaaac ttgacagtca1921 tgaaaggtaa ggcaaatttt aagtgggtta agtttttaaa tacgtatcta ctcattttct1981 ttaaaaaaaa aaaaaaaaa<210>24<211>1218<212>DNA<213>Homo sapiens<400>241 acacaacttc agctgaggaa cttggcacgg ccagcttggg acccaggacc ctaacgcaga61 ggcgctgtgt ttggaagtcc cgctatcacg gccccccaga tggggcctgg acgatgcctc121 ctgacggcct tgttgcttct ggccctggcg ccaccgccgg aagcctccca gtactgcggc181 cgccttgaat actggaaccc agacaacaag tgctgcagca gctgcctgca acgcttcggg241 ccgcccccct gcccggacta tgagttccgg gaaaactgcg gactcaatga ccacggcgat301 ttcgtaacgc ccccgttccg aaagtgttct tctgggcagt gcaaccccga cggcgcggag361 ctatgtagcc cctgcggcgg cggagccgtg acccctactc ccgccgcggg cgggggcaga
421 accccgtggc gctgcagaga gaggccggtc cctgccaagg ggcactgccc cctcacacct481 ggaaacccag gcgcccctag ctcccaggag cgcagctcac cagcaagttc cattgcctgg541 aggacccctg agcctgtccc tcagcaggcc tggccgaatt tccttccgct cgtggtgctg601 gtcctgctcc tgaccttggc ggtgatagcg atcctcctgt ttattctgct ctggcatctc661 tgctggccca aggagaaagc cgacccctat ccctatcctg gcttggtctg cggagtcccc721 aacacccaca ccccttcctc ctcgcatctg tcctccccag gcgccctgga gacaggggac781 acatggaagg aggcctcact acttccactc ctgagcaggg aactgtccag tctggcgtca841 caacccctgt ctcgcctcct ggatgagctg gaggtgctgg aagagctgat tgtactgctg901 gaccctgagc ctgggccagg tgggggtatg gcccatggca ctactcgaca cctggccgca961 agatatgggc tgcctgctgc ctggtccacc tttgcctatt cgctgaggcc gagtcgctcg1021 ccgctgcggg ctctgattga gatggtggtg gcaagggagc cctctgcctc cctgggccag1081 cttggcacac acctcgccca gctagggcgg gcagatgcat tgcgggtgct gtccaagctt1141 ggctcatctg gggtttgctg ggcttaacac ccaataaaga actttgctga ctactaaaaa1201 aaaaaaaaaa aaaaaaaa<210>25<211>1951<212>DNA<213>Homo sapiens<400>251 gagcccggag caggccgggc tcaagaaaga ggaaagttga ggacgcccca cctcggagag61 gcggcgcccc tgagtaggcc aggagcctct cttgcaactt ctgccaccgc gggccaccgc121 ggccgcctga tcccgcagag gaaggtcgcg gccgtggagc gatgacccgc ggcggtccgg181 gcgggcgccc ggggctgcca cagccgccgc cgcttctgct gctgctgctg ctgctgccgc241 tgttgttagt caccgcggag ccgccgaaac ctgcaggagt ctactatgca actgcatact301 ggatgcctgc tgaaaagaca gtacaagtca aaaatgtaat ggacaagaat ggggacgcct361 atggctttta caataactct gtgaaaacca caggctgggg catcctggag atcagagctg421 gctatggctc tcaaaccctg agcaatgaga tcatcatgtt tgtggctggc tttttggagg481 gttacctcac tgccccacac atgaatgacc actacacaaa cctctaccca cagctgatca541 cgaaaccttc catcatggat aaagtgcagg attttatgga gaagcaagat aagtggaccc601 ggaaaaatat caaagaatac aagactgatt cattttggag acatacaggc tatgtgatgg661 cacaaataga tggcctctat gtaggagcaa agaagagggc tatattagaa gggacaaagc721 caatgaccct gttccagatt cagttcctga atagtgttgg agatctattg gatctgattc781 cctcactctc tcccacaaaa aacggcagcc taaaggtttt taagagatgg gacatgggac841 attgctccgc tcttatcaag gttcttcctg gatttgagaa catccttttt gctcactcaa901 gctggtacac gtatgcagcc atgctcagga tatataaaca ctgggacttc aacatcatag961 ataaagatac cagcagtagt cgcctctctt tcagcagtta cccagggttt ttggagtctc1021 tggatgattt ttacattctt agcagtggat tgatattgct gcagaccaca aacagtgtgt1081 ttaataaaac cctgctaaag caggtaatac ccgagactct cctgtcctgg caaagagtcc1141 gtgtggccaa tatgatggca gatagtggca agaggtgggc agacatcttt tcaaaataca1201 actctggcac ctataacaat caatacatgg ttctggacct gaagaaagta aagctgaacc
1261 acagtcttga caaaggcact ctgtacattg tggagcaaat tcctacatat gtagaatatt1321 ctgaacaaac tgatgttcta cggaaaggat attggccctc ctacaatgtt cctttccatg1381 aaaaaatcta caactggagt ggctatccac tgttagttca gaagctgggc ttggactact1441 cttatgattt agctccacga gccaaaattt tccggcgtga ccaagggaaa gtgactgata1501 cggcatccat gaaatatatc atgcgataca acaattataa gaaggatcct tacagtagag1561 gtgacccctg taataccatc tgctgccgtg aggacctgaa ctcacctaac ccaagtcctg1621 gaggttgtta tgacacaaag gtggcagata tctacctagc atctcagtac acatcctatg1681 ccataagtgg tcccacagta caaggtggcc tccctgtttt tcgctgggac cgtttcaaca1741 aaactctaca tcagggcatg ccagaggtct acaactttga ttttattacc atgaaaccaa1801 ttttgaaact tgatataaaa tgaaggaggg agatgacgga ctagaagact gtaaataaga1861 taccaaaggc actattttag ctatgttttt cccatcagaa ttatgcaata aaatatatta1921 atttgtcact ttcaaaaaaa aaaaaaaaaa a<210>26<211>1530<212>DNA<213>Homo sapiens<400>261 agttcccagc tgtccgaaag gtcttcggaa cttcggctct aaagcgttcc tcagcgccat61 ccgcccggaa acacgagcga cagagaaaag gtccgcgagg ccggcagact ccagagtggc121 tgggtccgag cgcggggcgg gttgccgaag ggcctcggcc tgggctgcgt gctggagagc181 ggggacgggg ccgactcacc agaggctgca gcaacaggtc cactttgctc tccagtctct241 ttctccgaca ccgctgaggc ggtttcccac cgacttcctt tccatacagc accggcaggc301 accggggtga agggtcataa aaatggcgct ggccgctcgt ttgctacccc agttcctgca361 ctctcggtcg ctgccctgcg gggccgtccg actccggact cctgctgtgg ccgaggtgag421 gctgccgtcg gccacacttt gctacttctg ccgctgtcgc ctcggcttgg gagcggcgtt481 atttccacga agcgctaggg ccttggcagc ctcggcgcta cctgcccagg gctcccggtg541 gccagtgctc agcagcccgg gactccccgc agccttcgct tctttccctg cctgccctca601 gcgcagctac agcacggagg agaagcccca gcagcaccag aaaaccaaga tgatcgtcct661 gggattctcc aaccccatca actgggttag gactcgaatt aaggccttcc ttatctgggc721 ctatttcgac aaagagttca gcatcacaga gttctccgag ggagcgaagc aggcttttgc781 tcatgtatcc aagttgctgt cacagtgtaa atttgatctg ttggaagaac ttgtggccaa841 agaggtgcta catgcattga aagaaaaggt tacttcacta cctgacaacc ataaaaatgc901 ccttgctgct aacatagatg aaattgtatt tacatcaaca ggaggcatct ccatttacta961 tgatgagaaa ggaaggaagt ttgttaacat cctgatgtgc ttttggtatc taaccagtgc1021 caacatcccc agtgaaactt taagaggagc cagtgtattc caggttaagt tggggaatca1081 gaatgtggaa actaaacaac ttcttagtgc aagctatgag tttcagaggg agttcacaca1141 aggagtaaag cctgactgga ccattgcacg gattgaacac tcaaaattat tagaataatt1201 ttcttggaaa aatcagctta tggactttag cagttgctgt gaaaaactaa ggaagaaaaa1261 ttttggggtc atttgatctt cacttaatct aagtctgtga attactttta tattattttg1321 aaatactcct tgcagtatat tggcatgata cagtaaaagc attttccaca gattgttatc
1381 accttcttta aaagaagtca aaatttaaaa aatacaatag cacgttgttg gtgtcatatt1441 caataacatt tccaatgcta catataattt tatagacata ataaagaagg tattgaaaaa1501 actaaaaaaa aaaaaaaaaa aaaaaaaaaa<210>27<211>1468<212>DNA<213>Homo sapiens<400>271 gggagagtgg tggcatctga gaggctggtc gtggactgtg gttgggggag gtgggagctg61 ttttaaccgt gtgccccctc tcctgtgccg gcgtgggcat cccccggggc agtggaacgc121 gggcgctcct ccagcttccg agtccagcca gcctgggcgc ggggcgccgc ccccgagaca181 cccgaggagt ccgttcctcc ctggttacgt ggactgtgga gctggtctct tgtggctcag241 cgccgtgcgg aggttgaagc gtacctgcgg aggtcgcacc agggcgtgag gaggaggagg301 aagggcatga gccgagcttg aggaatccgt gctccaaact ctacactcaa gggtggccct361 tgggtagggt gaagatcccc tgtctttatc ctagttccac accttggtgt gggttactgg421 gtgcaggatg aactgtcgct cggaggtgct ggaggtgtcg gtggaggggc ggcaggtgga481 ggaggccatg ctggctgtgc tgcacacggt gcttctgcac cgcagcacag gcaagttcca541 ctacaagaag gagggcacct actccattgg caccgtgggc acccaggatg ttgactgtga601 cttcatcgac ttcacttatg tgcgtgtctc ttctgaggaa ctggatcgtg ccctgcgcaa661 ggttgttggg gagttcaagg atgcactgcg caactctggt ggcgatgggc tggggcagat721 gtccttggag ttctaccaga agaagaagtc tcgctggcca ttctcagacg agtgcatccc781 atgggaagtg tggacggtca aggtgcatgt ggtagccctg gccacggagc aggagcggca841 gatctgccgg gagaaggtgg gtgagaaact ctgcgagaag atcatcaaca tcgtggaggt901 gatgaatcgg catgagtact tgcccaagat gcccacacag tcggaggtgg ataacgtgtt961 tgacacaggc ttgcgggacg tgcagcccta cctgtacaag atctccttcc agatcactga1021 tgccctgggc acctcagtca ccaccaccat gcgcaggctc atcaaagaca cccttgccct1081 ctgagcgtcg ctggatctct gggagctcct tgatggctcc cagaccttgg cttttgggaa1141 ttgcactttt gggcctttgg gctctggaac ctgctctggg tcattggtga gacttggaag1201 gggcagcccc cgctggcttc ttggttttgt ggttgccagc ctcaggtcat ccttttaatc1261 tttgctgacg gttcagtcct gcctctactg tctctccata gccctggtgg ggtccccctt132t ctttctccac tgtacagaag agccaccact gggatgggga ataaagttga gaacatgagt1381 ttgggctgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaa<210>28<211>1817<212>DNA<213>Homo sapiens
<400>281 aaaaatcaga ataagaagta cctgacatac tttctacatc tgtagttgcg gaagacattt61 taataggtct tctcatagcc tttctttgct aaggacattg tgactctcca gagagcaaca121 gtgatggctc tagaatgtct aggaaaaaga agggcttaat gtcaggagtc tgcttggggc181 acacaacact agaagatgtc cttctgcaca ttgtttcata tcgagtatgg aacccttcag241 atcaaagctt accaataaat tcagtatgta gaacagatta acgtagttga aatgaggaag301 aatgagagtt atctcaacca gccagcaccc cctatcccca ttcccacact ttccctcatg361 ggaggctgtc gggagcactt cgaaaaccac tggaaaggcc gggcacggtg gctcatgcct421 gtaatcccag cactttggga ggccaaggca ggcagatcac ctgaggtcag gagttcgaaa481 ccagcctggc caacatggcg aaaccccatc tttactaaaa atacgaaaat tagccaggta541 ttagaattat ttctgaatta tcagtctctc atttgtgctt tggagaagca gaaaaggcaa601 aaggggtctt tggccatctt ctgctggagc ttccagggag gatgtgtctc caagagacca661 gatgtaccga gtttgaaatc ccagaagccc aagaggaaaa gaatcacagg gaggaaaaga721 ctgtccaaag gcttctggag tcttctgttc tctaaccttg gaaggttttg aacaatattt781 ctcagaggat agcctttcac ttattcatct gtccagcatg actcatcccc gggagtgttg841 agtaagtgaa attttgctgt attcatgttt ttgtgactta taaaatagga tgataaggag901 agaacatgaa ctctggagtc agacctgtta cctcggacat gatactctta gctttgtcat961 ttagtatttg agtaattttg ggcaagctaa catctctggt cgttctcatc tgtaaaatga1021 gaataaatga aacccactaa ccagaattgg tatgaaaatg aaatgtggca gaaaaaaaat1081 gaaagtgaat agtatcacca ctgacacaca agcactaaag gcccttcctg tctccatcag1141 gtatggattt ggggcaacat ttggccagat cttgtttatc tttctgttca tctattctgt1201 ctaattcagt gctttgttta caacgaatgt cttacaaatg ctgactgaac actagcatac1261 ctgcatgaac aacaggtaaa taaattttag atgtgtttta atgtttatta atctatcctg1321 tcagagaaga actgccagtt atagataaat atgatgccag gtcagggctg aagagttggg1381 caggttgtta tctgcatggg gtcactaggt tccagtggag aggtgggggc taagctctca1441 cccgctctgc agccacctgg cacccggttt cagtttcctg aaagggagcc ttctacttgc1501 tgacgactgc ctcatctctt ctgaggtttc ctctgataaa caattttctc tgcttttttt1561 ttttaattat gaaatactta aaatgtaaag gagataatgt gacacacatt tacccataat1621 tgagattgcc ataattgcta taactttttc aaaattttga cttaatttca gacttttaga1681 aaaattggcc aggtgtgatg gctcatgcct gtaatcccag cactttggga ggccaaggtg1741 ggtaaattac ttgaacccag cagttcgaga cttgcctggg cggcatagtg agaccttgtc1801 tctactgaaa acaaact<210>29<211>1466<212>DNA<213>Homo sapiens<400>291 atactcacca ggatacccct cgttaagggc aaggcggctt ctggctcttc cgcaggctca61 gttgtgggtt cctgtgtgct tagtcatcgg gtccgacaca ggctggactg atctggagag
121 ccgcgaaggg cctgccttca caaagggacg taacgcaagt actgcgggca gtgtttgaat181 atggccctga acaatgtgtc cctgtcctcc ggtgatcaga ggagcagggt ggcctaccgc241 tcttcccatg gcgacctcag accgcgggcg tcagcgttgg cgatggtctc cggagacggc301 ttcctcgttt ccaggcctga agcgattcat ctaggacctc ggcaggcggt gcgaccaagc361 gttcgggccg agagccgtcg agtggatggt ggcggccgga gcccaaggga accagatggc421 cggggccgga gccgccaagc cagattctca ccttacccaa tccctgccgt tgaacccgat481 ctcctaagaa gtgtgctgca acagcgtttg attgcattag gaggtgttat cgcagctcga541 atttcagttt aaacgaacac ctttcctctg gccctcactt agcttgtgaa caggcctttt601 taaaatcctt tcttggtgta gcagcaatcg tgttgtttta tttttagatg gatgtatttt661 catttaatac gtgggagtta tatgaatatg tcctagcact aagggaagtg taacagttga721 ttgatttagg tggttttatg cagccagaac gattggaaca ggaaaggtgt ggaagggata781 ttcttaggtc gtcacaaagc tgagctgatg ggagcaccct ccccagaggt caacaatcca841 ttcgttaact cagacactta acctttacct ttacttctgt tggcgaaaaa gaagtgctcc901 tttttattac actgatttat ccttccatct tttccttggc atttaccatc ttccatctcc961 cccttcactt ttttcagata tgtctacaaa cagactccaa tctcagtcgc actaaaaata1021 agaacaaaac ctaaacctta cagttctttc aaattattaa atcaatttat tattcctttc1081 tttggcaaag gttccaaatt tttactttat atttgtaatt ttactatttg cattcagtcc1141 cagcgcatta atctgaatct gctgtcctaa aatacactgg tgaaaacatt acttgtacaa1201 tctcctatca gaaaactgtt catctactca ctgtagtgcc ctccttgaaa tgtgtgtttg1261 ttcattcaac taacaatatt tggggatccc tgtagtaaac actgtatgaa ttttacacag1321 tctggccatc aagaaagatc acggagtata ttctagatgg ggaggctact aagtgaatag1381 gaatcaccac gctgggctgt ttattaggta cagtaataaa cataagtact ggttgcagtg1441 aaaaaaaaaa aaaaaaaaaa aaaaaa<210>30<211>1925<212>DNA<213>Homo sapiens<400>301 gcggccgtcg cgtctgacag accactgcag accacgggcc gaggcccagc gcccgtccgc61 agcgcggccg gcatggcggc gacaaggagc cccacgcggg caagggagcg ggagcggtct121 ggcgctcccg ccgcaggaag tgaccaagtt cactcctgga tgctagctac aagccaagcc181 ttagacactg tctggagaat ggcaaaaggc tttgtgatgt tggcagtttc atttctggtg241 gctgccatct gctacttccg gaggctacat ttatattcag ggcacaagct gaaatggtgg301 attggatatc tgcagagaaa attcaaaagg aacctcagtg tggaggcaga ggttgattta361 ctcagttatt gtgcaagaga atggaaagga gagacacccc gtaacaagct gatgaggaag421 gcttatgagg agctattttg gcggcatcac attaaatgtg ttcgacaagt aaggagagat481 aactatgatg ctctcagatc agtgttattt cagatattca gccagggcat ctcttttcca541 tcatggatga aagaaaagga cattgttaag cttcctgaaa aactgctgtt ttcacaaggt601 tgtaattgga ttcagcagta cagttttggt cctgagaagt atacaggctc gaatgtgttt661 ggaaaactac ggaaatatgt ggaattattg aaaacacagt ggactgaatt taatggcatt
721 agagattatc acaagagagg aagtatgtgc aacacccttt tttcagatgc cattctggaa781 tataaacttt atgaagcttt aaagttcatc atgctgtatc aagtcactga agtttatgaa841 caaatgaaga ctaaaaaggt cattcccagt ctttttagac tcctgttttc cagggagaca901 tcctctgatc ctttgagctt catgatgaat cacctgaatt ctgtaggcga cacatgtgga961 ctagagcaga ttgatatgtt tatacttgga tactcccttg aagtaaagat aaaagtgttc1021 agactgttca agtttaactc cagagacttt gaagtctgct acccagagga gcctctcagg1081 gactggccgg agatctccct gctgaccgag aacgaccgcc actaccacat tccagtcttt1141 taagtccgct gggggccgaa cagcagtgct caccagtgac ggtggtcaca gttgcaataa1201 agtctctctc tgaaaccaaa gctagcattt cagcatggaa ggaattagga ccttttcttc1261 aggattacag gtacactgga tgcagccatg catggatggt ttttctttat ttttcagtga1321 tttcctctga agcagctgca ctgatacatt tgggagttgg tggcttgact ttgtccataa1381 ggggcgtggc cacttcacat gatggcgggc ctttaagagc acaaagaagt ttaatatgga1441 caacaacagg aaaaagcaag aagaaaacaa gtagggaaaa acagctaacc tggagagaaa1501 gaatttcttt aacctttatg ttcttcatta aaaatcttat cttggactga tttgagggat1561 ttttagaaac atggccttat tttatataag cattaccttc ccaggaatct ttgttgtata1621 ttaatttttg ataaccattt gattaacttt aaaattaagt atatgtgtgt atatatacat1681 atgtatgttt atatacacac atgtatctgt atagttttat atatacatat atacacatag1741 acatacagag aaccactact ttgtaatagt gtacagtttg ttttatatct ctttactttt1801 tttgttacta ttttatctgg ccagcgtaat agttttattt agatttttta aaattctgta1861 gattaaagca aatgacagtt attgaactat cacaaaacta ttaaactgtg gtacatttaa1921 tgtgt
权利要求
1.一类人类肝脏相关基因，其包括以下序列的基因(a)SEQ ID No.1～SEQ ID No.30所示的序列；(b)SEQ ID No.1～SEQ ID No.30所示的序列中每条序列的互补序列；(c)与SEQ ID No.1～SEQ IDNo.30所示的序列中每条序列有至少70％同源性的序列，及(d)上述(a)～(c)中一条或数条的组合。
2.根据权利要求1所述的一类人类肝脏相关基因，其特征在于所述人类肝脏相关基因包括具有SEQ ID No.1～SEQ ID No.30所示序列的基因。
3.一种探针分子，其特征在于所述的探针分子含有权利要求1中所述的序列中约8-100个连续的核苷酸。
全文摘要
本发明公开了一类人类肝脏相关基因。本发明的人类肝脏相关基因与一些肝脏疾病相关，在研究肝脏疾病的致病机理以及开发治疗肝脏疾病的药物中发挥重要作用。
文档编号C07H21/00GK1970754SQ20051011058
公开日2007年5月30日 申请日期2005年11月22日 优先权日2005年11月22日
发明者黄健, 韩泽广 申请人:上海人类基因组研究中心