毒力基因、蛋白及其用途的制作方法

专利名称：毒力基因、蛋白及其用途的制作方法
技术领域：
本发明涉及毒力基因和蛋白及其用途。更具体地说，本发明涉及从脑膜炎奈瑟氏球菌(Neisseria meningitidis)中得到的基因和蛋白质/肽，及其在治疗和筛选药物中的应用。
背景技术：
脑膜炎奈瑟氏球菌是一种引起败血症性休克和细菌性脑膜炎的革兰氏阴性致病菌。在发展中国家这种细菌是细菌性脑膜炎的主要病因，并在非洲和中国引起大规模流行。在英国，脑膜炎奈瑟氏球菌是除道路交通事故外儿童死亡的主要原因。该细菌天然栖居于人鼻咽部，然后进入血流并由此引起严重的败血症或脑膜炎。尽管现有的抗微生物药可以有效地将细菌从机体中清除，脑膜炎球菌性败血症的死亡率仍相当可观。期望提供治疗或预防由脑膜炎奈瑟氏球菌引起的病症的方法，例如通过免疫。
发明概述本发明是基于发现了脑膜炎奈瑟氏球菌中的毒力基因。
根据本发明的第一方面，本发明的肽是由操纵子编码的，所述操纵子包括权利要求1中鉴定的任何核苷酸序列，或其在革兰氏阴性细菌中的同源物、或其功能片段，用于治疗或诊断。
所述肽对于治疗奈瑟氏球菌感染具有许多治疗应用，包括用于预防性应用的疫苗中。
根据第二方面，编码上述肽的多核苷酸也可以用于治疗或诊断。
根据第三方面，编码所述肽的基因可以用于制备减毒微生物。减毒微生物通常具有破坏在此鉴定的一个或多个基因的表达的突变，从而提供缺乏毒力的菌株。这些微生物也可用于治疗和诊断。
根据第四方面，本发明的肽、基因和减毒微生物可以用于治疗或预防与奈瑟氏球菌或革兰氏阴性细菌感染有关的病症。
发明详述本发明是基于发现了编码涉及毒力的肽的基因。因此本发明的肽和基因可用于制备治疗感染的治疗剂。应该理解治疗还包括预防性治疗，如接种疫苗。此外，尽管本发明的产物主要旨在治疗人类患者的感染，认为兽医应用也在本发明的范围之内。
本发明针对脑膜炎奈瑟氏球菌进行描述。然而所有的奈瑟氏球菌菌株和许多其它革兰氏阴性菌株很可能包括与在此鉴定的肽或蛋白具有氨基酸序列同一性或相似性的相关肽或蛋白。可能含有所述肽的微生物包括但不限于沙门氏菌属(Salmonella)、肠杆菌属(Enterobacter)、克雷伯氏菌属(Klebsiella)、志贺氏菌属(Shigella)和耶尔森氏菌属(Yersinia)。
为鉴定本发明的毒力基因而进行的试验使用了脑膜炎奈瑟氏球菌B株。对A株数据库进行了同源性检索，然而优选B株的蛋白和基因。
优选地，可用于本发明各方面的肽与在此鉴定的肽具有大于40％的相似性。更优选地，所述肽具有大于60％的序列相似性。最优选地，所述肽具有大于80％的序列相似性，如95％相似性。对于在此鉴定的多核苷酸序列，可用于本发明各方面的相关多核苷酸可以与在此鉴定的序列具有大于40％的同一性。更优选地，所述多核苷酸序列具有大于60％的序列同一性。最优选地，所述多核苷酸序列具有大于80％的序列同一性，如95％同一性。
术语“相似性”和“同一性”在本领域中是已知的。使用术语“同一性”是指基于在所比较序列中对应相同位点之间相同匹配的序列比较。术语“相似性”指氨基酸序列之间的比较，并且不仅考虑在相应位点的相同氨基酸，还考虑在相应位点的功能相似氨基酸。因而多肽序列之间的相似性除了序列相似性之外还表示功能相似性。
基因序列之间的同一性水平和氨基酸序列之间的同一性或相似性水平可以用已知方法计算。关于本发明，公众可得到的确定同一性和相似性的基于计算机的方法包括BLASTP、BLASTN和FASTA(Atschul等，J.Molec.Biol.，1990；215403-410)，可从NCBI得到的BLASTX程序，以及Genetics Computer Group，Madison WI的GAP程序。在此提供的相似性和同一性水平，是用GAP程序获得的，用GAP罚为12和GAP长度罚为4来确定氨基酸序列比较，用GAP罚为50和GAP长度罚为3来进行多核苷酸序列比较。
通过表征本发明的基因，可以使用所述基因序列在其它微生物中搜索相关的基因或肽。这可以通过在现有的数据库如EMBL或GenBank中搜索来进行。
本发明的肽或蛋白可以用本领域已知的方法进行纯化和分离。特别是，鉴定了基因序列后，可以使用重组技术在合适的宿主中表达所述基因。可以鉴定出活性片段和相关分子并用于治疗。例如，所述肽或其活性片段可以用作疫苗中的抗原决定簇以引发免疫应答。它们还可以用于制备抗体，用于被动免疫或诊断应用。合适的抗体包括单克隆抗体或其片段，包括单链Fv片段。制备抗体的方法对本领域的技术人员是显而易见的。
所述肽的活性片段是那些保留肽的生物学功能的片段。例如，当用于引发免疫应答时，所述片段的大小足以使由该片段产生的抗体区分该肽与细菌微生物上的其它肽。通常，片段大小为至少30个核苷酸(10个氨基酸)，优选60个核苷酸(20个氨基酸)，最优选大于90个核苷酸(30个氨基酸)。
同时应该理解，除了来自其它微生物的相关分子之外，本发明还包括对在此鉴定的肽和多核苷酸所作的不明显改变其生物学功能的修饰。本领域的技术人员很清楚，遗传密码子的简并性可以产生与在此鉴定的多核苷酸具有较小碱基改变的多核苷酸，但仍编码相同的肽。互补多核苷酸也在本发明范围之内。还可以预计在氨基酸水平的保守替换，即不同的酸性或碱性氨基酸可以被置换而实质上不丧失功能。
基于减毒微生物制备疫苗是本领域技术人员已知的。可以用合适的载体或佐剂如明矾，作为必需或理想成分，来配制疫苗组合物，以提供对抗感染的有效免疫。疫苗制剂的制备对本领域的技术人员是显而易见的。可以制备带有破坏在此鉴定的任何基因表达的突变的减毒微生物。本领域的技术人员知晓破坏特定基因表达的方法。可以使用的技术包括插入失活或基因缺失技术。本发明的减毒微生物还可以包含其它基因的额外突变，例如在第二个在此鉴定的基因或微生物生长所需的单独基因中，如aro突变，或对于沙门氏菌来说，在WO-A-96/17951中鉴定的位于SP12区的基因中。
还可以将减毒微生物用作递送异源性抗原、治疗性蛋白或核酸(DNA或RNA)的载体系统。在这个技术方案中，用减毒微生物递送异源性抗原、蛋白或核酸至体内的特定部位。可以通过常规技术将异源性抗原、肽或核酸引入减毒微生物，包括使用重组构建体，如载体，其包含表达异源性抗原或治疗性蛋白的多核苷酸，还包括适合的启动子序列。或者，可以将编码异源性抗原或蛋白的基因引入微生物的基因组，并且内源启动子用于控制表达。
更普遍地，正如本领域的技术人员所熟知的，可以选择合适量的本发明的活性成分以及合适的载体或赋形剂和给药途径用于治疗。可以根据已知的指标如待治疗的病症的性质/严重程度、受治疗者的类型和/或健康情况等选择或确定这些因素。
在一个独立的技术方案中，可以将本发明的产物用于鉴定潜在有效抗微生物药物或检测毒力的筛选试验中。常规的筛选试验是本领域技术人员熟知的，并可以用本发明的产物以适宜的方式作改动。例如，可以将本发明的产物用作潜在药物的作用靶，药物使靶失活或与靶结合的能力表示其潜在的抗微生物活性。
本发明的各种产物还可以用于兽医应用。
以下简要概括用于鉴定毒力基因的试验步骤。
用特征-标记诱变(STM)(Hensel等，Science，1995；269400-403)鉴定脑膜炎奈瑟氏球菌中引起败血症感染必需的基因。在STM中，用独特的序列标识标记各突变体，使得可以同时分析大量的突变体。但是，必需构建插入突变体的文库，这是目前在研究脑膜炎奈瑟氏球菌中的一个局限。用Tn10转座的纯化成分在体外修饰奈瑟氏球菌DNA从成功地完成诱变。由于脑膜炎奈瑟氏球菌能有效地摄取外源DNA，随后将经修饰的等位基因通过转化引入脑膜炎奈瑟氏球菌。然后筛选突变体引起全身感染的能力。
使用载体pSTM115(Sun等，Nature Medicine，2000；6(11)1269-1273)作为在体外诱变的转座子供体。在96个独立的转座反应中包括各含独特的特征标记的96个pSTM115衍生物。修复经修饰的基因组DNA，并通过转化返还宿主。为了确定Tn10插入是否发生在不同位点，通过DNA印迹分析评估来自单个转座反应的40个转化体。每个转化体均具有单一的不同的Tn10插入。为了确定Tn10整合在幼鼠全身感染期间是否稳定，比较6个突变体在经大鼠传代之前和之后的杂交模式。在感染之前和之后得到相同的杂交模式。
所用的试验条件如下细菌菌株和生长C311+是从一名侵袭性脑膜炎球菌感染患者中分离到的ET-5血清群B脑膜炎奈瑟氏球菌(Virji等，Mol.Microbiol.，1991；51831-1841)。在含有5％Levinthal补充物的脑-心浸液培养基上培养脑膜炎奈瑟氏球菌。在Luria Bertani培养基上繁殖大肠杆菌菌株。将卡那霉素按需分别以75μg/ml(脑膜炎奈瑟氏球菌)和50μg/ml(大肠杆菌)的浓度加入固体培养基。
在体外转座和插入位点表征用pSTM115中的pACYC184复制起点通过标记获救来分离插入位点。用染料终止法进行核苷酸测序(Perkin Elmer，Norwalk，Connecticut)，使用引物NG62(5’-TTGGTTAATTGGTTGTAACACTGG-3’)(SEQ ID NO.209)或NG99(5’-ATTCTCATGTTTGACAGCG-3’)(SEQ IDNO.210)。对蛋白质数据库(http//www.ncbi.nlm.nig.gov/)进行同源性检索，包括脑膜炎奈瑟氏球菌血清群A和B以及淋病奈瑟氏球菌(N.gonorrhoeae)基因组序列(分别在http//www.sanger.ac.uk/Projects/N_meningitidis和http//www.tigr.org，以及http//dna1.chem.ou.edu/gono.html)。
标记扩增、克隆和DNA印迹分析如Hensel等上文所述进行斑点印迹的杂交和制备，除外标记用引物NG13(5’-ATCCTACAACCTCAAGCT-3’)(SEQ ID NO.211)和NG14(5’-ATCCCATTCTAACCAAGC-3’)(SEQ ID NO.212)扩增，并将PCR产物而不是质粒DNA固定到膜上。将寡核苷酸S1(5’-AAGAGATTACGCGCAGACC-3’)(SEQ ID NO.213)和S2(5’-AATACGCAACCGCCTCTC-3’)(SEQ ID NO.214)与pSTM115中‘特征标记’两侧的序列退火，并用于从各pSTM115衍生物扩增367碱基对的产物。对于DNA印迹分析，用随机引物方法(NEB)标记来自pSTM115的卡那霉素抗性盒，并将其用作针对用ClaI消化的基因组DNA的探针。
动物模型为了筛选STM库，将突变体在微量滴定板中各培养18小时。收集细菌，然后重悬于PBS中。用100μl悬液对Wistar大鼠(出生5天)作腹膜内接种，并监测48小时。为了确定突变体的竞争指数，将野生型和突变体细菌在固体培养基上培养18小时，并收集到PBS中，用1∶1突变体对野生型细胞的比例以5×106CFU的总接种量接种大鼠。突变体(卡那霉素耐药)对野生型(卡那霉素敏感)细菌的比例通过将重复样本平板接种到添加有抗生素或无抗生素的培养基平板上培养来确定。
同源性搜索的结果如表1所示。
表1
对于在此鉴定的其余序列，没有获得同源性结果。
用基因产物产生多克隆抗体，将抗体在Elisa分析中针对各种脑膜炎奈瑟氏球菌菌株进行测试，以评价其作为候选疫苗的有效性。所用的菌株为脑膜炎奈瑟氏球菌(B)1000型脑膜炎奈瑟氏球菌(B)NGE31型脑膜炎奈瑟氏球菌(B)NGH15型脑膜炎奈瑟氏球菌(B)SW2107型脑膜炎奈瑟氏球菌(B)NHG38型脑膜炎奈瑟氏球菌(B)NGE28型脑膜炎奈瑟氏球菌(B)2996型这提供了关于被这些抗体识别的脑膜炎奈瑟氏球菌菌株的多样性的信息。
将脑膜炎奈瑟氏球菌在含有巧克力化马血的哥伦比亚琼脂(Oxoid)上在37℃5％CO2中培养14小时。从琼脂平板上将细胞刮下并重悬于50ml试管内的20ml PBS中。将细胞悬液在56℃加热30分钟以杀死细菌。
取50μl经加热杀死的脑膜炎奈瑟氏球菌样本铺展在含有巧克力化马血的哥伦比亚琼脂上并在37℃5％CO2中培养18小时。这可以证实所有的脑膜炎奈瑟氏球菌细胞已被杀死。相对于PBS将悬液的OD620调节到0.1OD单位。
用经加热杀死的脑膜炎奈瑟氏球菌进行Elisa采用下列方案用经加热杀死的脑膜炎奈瑟氏球菌进行Elisa测定。用经加热杀死的细胞将Elisa板包被过夜(向96孔板的每孔中加入50μl死细菌的PBS悬液，并在4℃温育)。
遵循标准的Elisa方案，所有的温育均在37℃进行1小时。使用PBS/3％BSA封闭液，PBS/Tween 0.1％冲洗液，抗兔AP结合二抗(Sigma)和Sigma Fast对硝基苯磷酸检测试剂(Sigma)。用适宜的微量滴定板读出器在405nm读取数据。所用的血清是初次加强接种后7天(初次接种后35天)得到的。
所测试的抗体是那些针对如SEQ ID NO.8，102，140，158和202所示基因产物产生的抗体。在每种情况下结果均显示抗血清识别几株不同的脑膜炎奈瑟氏球菌B菌株。
离体/体外筛选对人类脑膜炎球菌疾病的保护与存在对抗脑膜炎奈瑟氏球菌的杀菌性抗体有关(Goldscheider等，J.Exp.Med.，1969；1291307-1326)。还有证据提示存在可检测到的杀菌活性与体内模型中的保护相关(参见Martin，J.Bacteriol.，2000；8327-31)。因此，用产生的抗血清评价所产生的抗体的杀菌活性。
用免疫前血清和针对候选抗原产生的相应兔抗血清进行杀菌试验。进行预筛选以排除仅依靠补体的杀伤之后用市售的兔血清作为补体来源。在必要时用Dulbecco氏PBS(Gibco)作为缓冲液。在用于试验之前将脑膜炎奈瑟氏球菌菌株MC58在37℃(5％CO2)培养14小时。
将50μl体积的含200-400CFU的MC58在补体(50μl)存在下与100μl系列稀释的热灭活血清一起温育。将在0时间的样本平板接种到含有巧克力化马血的哥伦比亚琼脂(Oxoid)上培养。温育60分钟后，通过在含有巧克力化马血的哥伦比亚琼脂(Oxoid)上平板培养来估计存活的细菌数。杀菌活性表示为60分钟后细菌存活的百分比。所有的样本测试一式两份并且平板培养一式三份。使用所有适宜的阳性和阴性对照。在各测试样本中，杀菌活性实质上都大于免疫前血清。
体内筛选为了评估候选疫苗的保护效力，用在此鉴定的如SEQ IDNO.102和108所示的重组蛋白免疫成年小鼠，通过活细菌攻击测定保护性应答。对每种候选疫苗，用25μg抗原分别在相隔3周的两个时间对15只6周龄的小鼠(6周龄balb/C小鼠)进行接种。
免疫接种方案结束后一周，用同种细菌菌株MC58攻击该组。用在脑心浸液/0.5％铁葡聚糖培养基中的500μl细菌悬液以107cfu的剂量进行腹膜内接种。先前的结果显示在这些动物中需要铁来引发菌血性疾病。该模型之前被用于证实疫苗接种的保护性效力(Lissolo等，Infect.Immujn.，1995；63884-890)。
对照组包括单独用佐剂接种的动物(阴性对照)或用佐剂联合纯化PorA接种的动物(阳性对照)。PorA是一种仅由脑膜炎奈瑟氏球菌表达的外膜蛋白，并且是由外膜囊疫苗诱导产生的杀菌抗体的主要攻击目标。也已显示针对PorA的单克隆抗体在幼鼠模型中被动地保护动物。然而PorA在菌株之间差异很大，因此尽管其在用同种菌株攻击时引发某些保护，它并不是理想的候选疫苗。在攻击后监测存活率。阴性对照在48小时后无存活。用PorA接种的动物在72小时时有6只存活。而用SEQ ID NO.102和108蛋白接种的动物分别有5只和3只存活。
序列表<110>Microscience Limited<120>毒力基因和蛋白质及其用途<130>REP06436WO<140>not yet known<141>2001-05-08<150>0011108.8<151>2000-05-08<160>214<170>PatentIn Ver.2.1<210>1<211>1674<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1674)<400>1atg ctg acc tat acc ccg ccc gat gcc cgc ccg ccc gcc aaa acc cac48Met Leu Thr Tyr Thr Pro Pro Asp Ala Arg Pro Pro Ala Lys Thr His1 5 10 15gaa aag ccg tgg ctg ttg ctg ttg atg gcg ttt gcc tgg ttg tgg ccc96Glu Lys Pro Trp Leu Leu Leu Leu Met Ala Phe Ala Trp Leu Trp Pro20 25 30ggc gtg ttt tcc cac gat ttg tgg aat cct gac gaa cct gcc gtc tat144Gly Val Phe Ser His Asp Leu Trp Asn Pro Asp Glu Pro Ala Val Tyr35 40 45acc gcc gtc gaa gca ctg gca ggc agc ccc acc cct ttg gtt gcc cat192Thr Ala Val Glu Ala Leu Ala Gly Ser Pro Thr Pro Leu Val Ala His50 55 60ctg ttc ggt caa atc gat ttc ggc ata ccg ccc gtg tat ctt tgg gtt240Leu Phe Gly Gln Ile Asp Phe Gly Ile Pro Pro Val Tyr Leu Trp Val65 70 75 80
gcc gcc gcg ttc aaa cat ttg ctg tcg ccg tgg gct gcc gac ccg tat288Ala Ala Ala Phe Lys His Leu Leu Ser Pro Trp Ala Ala Asp Pro Tyr85 90 95gat gcc gca cgc ttt gcc ggc gtg ttt ttc gcc gtt gtc gga ctg act336Asp Ala Ala Arg Phe Ala Gly Val Phe Phe Ala Val Val Gly Leu Thr100 105 110tcc tgc ggc ttt gcc ggt ttc aac ttt ttg ggc aga cac cac ggg cgc384Ser Cys Gly Phe Ala Gly Phe Asn Phe Leu Gly Arg His His Gly Arg115 120 125agc gtc gtc ctg att ctc atc ggc tgt atc ggg ctg att ccg acc gta432Ser Val Val Leu Ile Leu Ile Gly Cys Ile Gly Leu Ile Pro Thr Val130 135 140cac ttt ctc aac ccc gct gcc gcc gcc ttt gcc gcc gcc gga ctg gtg480His Phe Leu Asn Pro Ala Ala Ala Ala Phe Ala Ala Ala Gly Leu Val145 150 155 160ctg cac ggt tat tct ttg gct cgc cgg cgc gtg att gcc gcc tct ttt528Leu His Gly Tyr Ser Leu Ala Arg Arg Arg Val Ile Ala Ala Ser Phe165 170 175ctg ctc ggt acg ggt tgg acg ctg atg tcg ttg gca gca gct tat ccg576Leu Leu Gly Thr Gly Trp Thr Leu Met Ser Leu Ala Ala Ala Tyr Pro180 185 190gcg gca ttt gcc ctg atg ctg ccc ctg ccc gtg ctg atg ttt ttc cgt624Ala Ala Phe Ala Leu Met Leu Pro Leu Pro Val Leu Met Phe Phe Arg195 200 205ccg tgg caa agc agg cgt ttg atg ttg acg gca gtc gcc tcg ctt gcc672Pro Trp Gln Ser Arg Arg Leu Met Leu Thr Ala Val Ala Ser Leu Ala210 215 220ttt gcc ctg ccg ctt atg acc gtt tac ccg ctg ctc ttg gca aaa acg720Phe Ala Leu Pro Leu Met Thr Val Tyr Pro Leu Leu Leu Ala Lys Thr225 230 235 240cag ccc gcg ctg ttc gcg caa tgg ctc gac gat cac gtt ttc ggt acg768Gln Pro Ala Leu Phe Ala Gln Trp Leu Asp Asp His Val Phe Gly Thr245 250 255ttc ggc ggc gtg cgg cac att cag acg gca ttc agt ttg ttt tac tat816Phe Gly Gly Val Arg His Ile Gln Thr Ala Phe Ser Leu Phe Tyr Tyr260 265 270
ctg aaa aac ctg ctt tgg ttt gca ttg cct gcg ctg ccg ctg gcg gtt864Leu Lys Asn Leu Leu Trp Phe Ala Leu Pro Ala Leu Pro Leu Ala Val275 280 285tgg acg gtt tgc cgc acg cgc ctg ttt tcg acc gac tgg ggg att ttg912Trp Thr Val Cys Arg Thr Arg Leu Phe Ser Thr Asp Trp Gly Ile Leu290 295 300ggc gtc gtc tgg atg ctt gcc gtt ttg gtg ctg ctt gcc gtc aat ccg960Gly Val Val Trp Met Leu Ala Val Leu Val Leu Leu Ala Val Asn Pro305 310 315 320cag cgt ttt cag gat aac ctc gtc tgg ctg ctt ccg ccg ctt gcc ctg1008Gln Arg Phe Gln Asp Asn Leu Val Trp Leu Leu Pro Pro Leu Ala Leu325 330 335ttc ggc gcg gcg caa ctg gac agc ctg aga cgc ggc gcg gcg gcg ttt1056Phe Gly Ala Ala Gln Leu Asp Ser Leu Arg Arg Gly Ala Ala Ala Phe340 345 350gtc aac tgg ttc ggc att atg gcg ttc gga ctg ttt gcc gtg ttc ctg1104Val Asn Trp Phe Gly Ile Met Ala Phe Gly Leu Phe Ala Val Phe Leu355 360 365tgg acg ggc ttt ttc gcc atg aat tac ggc tgg ccc gcc aag ctt gcc1152Trp Thr Gly Phe Phe Ala Met Asn Tyr Gly Trp Pro Ala Lys Leu Ala370 375 380gaa cgc gcc gcc tat ttc agc ccg tat tat gtt cct gat atc gat ccc1200Glu Arg Ala Ala Tyr Phe Ser Pro Tyr Tyr Val Pro Asp Ile Asp Pro385 390 395 400att ccg atg gcg gtt gcc gta ctg ttc aca ccc ttg tgg ctg tgg gcg1248Ile Pro Met Ala Val Ala Val Leu Phe Thr Pro Leu Trp Leu Trp Ala405 410 415att acc cgc aaa aac ata cgc ggc agg cag gcg gtt acc aac tgg gcg1296Ile Thr Arg Lys Asn Ile Arg Gly Arg Gln Ala Val Thr Asn Trp Ala420 425 430gca ggc gtt acc ctg acc tgg gct ttg ctg atg acg ctg ttc ctg ccg1344Ala Gly Val Thr Leu Thr Trp Ala Leu Leu Met Thr Leu Phe Leu Pro435 440 445tgg ctg gac gcg gcg aaa agc cac gcg ccc gtc gtc cgg agt atg gag1392Trp Leu Asp Ala Ala Lys Ser His Ala Pro Val Val Arg Ser Met Glu450 455 460
gca tcg ctt tcc ccg gaa tta aaa cgg gag ctt tca gac ggc atc gag1440Ala Ser Leu Ser Pro Glu Leu Lys Arg Glu Leu Ser Asp Gly Ile Glu465 470 475 480tgt atc gac ata ggc ggc ggc gac cta cac acg cgg att gtt tgg acg1488Cys Ile Asp Ile Gly Gly Gly Asp Leu His Thr Arg Ile Val Trp Thr485 490 495cag tac ggc aca ttg ccg cac cgc gtc ggc gat gta caa tgc cgc tac1536Gln Tyr Gly Thr Leu Pro His Arg Val Gly Asp Val Gln Cys Arg Tyr500 505 510cgc atc gtc cgc ttg ccc caa aac gcg gat gcg ccg caa ggc tgg cag1584Arg Ile Val Arg Leu Pro Gln Asn Ala Asp Ala Pro Gln Gly Trp Gln515 520 525acg gtc tgg cag ggt gcg cgc ccg cgc aac aaa gac agt aag ttc gca1632Thr Val Trp Gln Gly Ala Arg Pro Arg Asn Lys Asp Ser Lys Phe Ala530 535 540ctg ata cgg aaa acc ggg gaa aat ata tta aaa aca aca gat1674Leu Ile Arg Lys Thr Gly Glu Asn Ile Leu Lys Thr Thr Asp545 550 555<210>2<211>558<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>2Met Leu Thr Tyr Thr Pro Pro Asp Ala Arg Pro Pro Ala Lys Thr His1 5 10 15Glu Lys Pro Trp Leu Leu Leu Leu Met Ala Phe Ala Trp Leu Trp Pro20 25 30Gly Val Phe Ser His Asp Leu Trp Asn Pro Asp Glu Pro Ala Val Tyr35 40 45Thr Ala Val Glu Ala Leu Ala Gly Ser Pro Thr Pro Leu Val Ala His50 55 60Leu Phe Gly Gln Ile Asp Phe Gly Ile Pro Pro Val Tyr Leu Trp Val65 70 75 80Ala Ala Ala Phe Lys His Leu Leu Ser Pro Trp Ala Ala Asp Pro Tyr85 90 95
Asp Ala Ala Arg Phe Ala Gly Val Phe Phe Ala Val Val Gly Leu Thr100 105 110Ser Cys Gly Phe Ala Gly Phe Asn Phe Leu Gly Arg His His Gly Arg115 120 125Ser Val Val Leu Ile Leu Ile Gly Cys Ile Gly Leu Ile Pro Thr Val130 135 140His Phe Leu Asn Pro Ala Ala Ala Ala Phe Ala Ala Ala Gly Leu Val145 150 155 160Leu His Gly Tyr Ser Leu Ala Arg Arg Arg Val Ile Ala Ala Ser Phe165 170 175Leu Leu Gly Thr Gly Trp Thr Leu Met Ser Leu Ala Ala Ala Tyr Pro180 185 190Ala Ala Phe Ala Leu Met Leu Pro Leu Pro Val Leu Met Phe Phe Arg195 200 205Pro Trp Gln Ser Arg Arg Leu Met Leu Thr Ala Val Ala Ser Leu Ala210 215 220Phe Ala Leu Pro Leu Met Thr Val Tyr Pro Leu Leu Leu Ala Lys Thr225 230 235 240Gln Pro Ala Leu Phe Ala Gln Trp Leu Asp Asp His Val Phe Gly Thr245 250 255Phe Gly Gly Val Arg His Ile Gln Thr Ala Phe Ser Leu Phe Tyr Tyr260 265 270Leu Lys Asn Leu Leu Trp Phe Ala Leu Pro Ala Leu Pro Leu Ala Val275 280 285Trp Thr Val Cys Arg Thr Arg Leu Phe Ser Thr Asp Trp Gly Ile Leu290 295 300Gly Val Val Trp Met Leu Ala Val Leu Val Leu Leu Ala Val Asn Pro305 310 315 320Gln Arg Phe Gln Asp Asn Leu Val Trp Leu Leu Pro Pro Leu Ala Leu325 330 335Phe Gly Ala Ala Gln Leu Asp Ser Leu Arg Arg Gly Ala Ala Ala Phe340 345 350
Val Asn Trp Phe Gly Ile Met Ala Phe Gly Leu Phe Ala Val Phe Leu355 360 365Trp Thr Gly Phe Phe Ala Met Asn Tyr Gly Trp Pro Ala Lys Leu Ala370 375 380Glu Arg Ala Ala Tyr Phe Ser Pro Tyr Tyr Val Pro Asp Ile Asp Pro385 390 395 400Ile Pro Met Ala Val Ala Val Leu Phe Thr Pro Leu Trp Leu Trp Ala405 410 415Ile Thr Arg Lys Asn Ile Arg Gly Arg Gln Ala Val Thr Asn Trp Ala420 425 430Ala Gly Val Thr Leu Thr Trp Ala Leu Leu Met Thr Leu Phe Leu Pro435 440 445Trp Leu Asp Ala Ala Lys Ser His Ala Pro Val Val Arg Ser Met Glu450 455 460Ala Ser Leu Ser Pro Glu Leu Lys Arg Glu Leu Ser Asp Gly Ile Glu465 470 475 480Cys Ile Asp Ile Gly Gly Gly Asp Leu His Thr Arg Ile Val Trp Thr485 490 495Gln Tyr Gly Thr Leu Pro His Arg Val Gly Asp Val Gln Cys Arg Tyr500 505 510Arg Ile Val Arg Leu Pro Gln Asn Ala Asp Ala Pro Gln Gly Trp Gln515 520 525Thr Val Trp Gln Gly Ala Arg Pro Arg Asn Lys Asp Ser Lys Phe Ala530 535 540Leu Ile Arg Lys Thr Gly Glu Asn Ile Leu Lys Thr Thr Asp545 550 555<210>3<211>1077<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1077)<400>3atg aaa aca ctg acc gta cac acc ccg tcc cac agc tac ccc atc ttt48Met Lys Thr Leu Thr Val His Thr Pro Ser His Ser Tyr Pro Ile Phe1 5 10 15atc ggc aac gga ctg ctg ccg cag gca gga agc ctg ctc aaa ccg cat96Ile Gly Asn Gly Leu Leu Pro Gln Ala Gly Ser Leu Leu Lys Pro His20 25 30ttg ggc aaa cgc gcc gcc atc atc acc aac gaa acc gtc gcc ccg ctc144Leu Gly Lys Arg Ala Ala Ile Ile Thr Asn Glu Thr Val Ala Pro Leu35 40 45tac ctc ggc acg ctt cag acg gca ttg gat gcg gca ggc gta tcc cat192Tyr Leu Gly Thr Leu Gln Thr Ala Leu Asp Ala Ala Gly Val Ser His50 55 60ttc agc atc atc ctg ccc gac ggc gag gcg cac aaa aac tgg cag acg240Phe Ser Ile Ile Leu Pro Asp Gly Glu Ala His Lys Asn Trp Gln Thr65 70 75 80ctc aac ctc atc ttt gac ggg ctg atg caa aac cgc gcc gaa cgc aaa288Leu Asn Leu Ile Phe Asp Gly Leu Met Gln Asn Arg Ala Glu Arg Lys85 90 95acc acg ctc atc gca ctg ggc ggc ggc gtg atc ggc gat atg acg ggt336Thr Thr Leu Ile Ala Leu Gly Gly Gly Val Ile Gly Asp Met Thr Gly100 105 110ttt gcg gcg gct act tat caa cgc ggc gcg cca ttt gtt caa att ccc384Phe Ala Ala Ala Thr Tyr Gln Arg Gly Ala Pro Phe Val Gln Ile Pro115 120 125act act tta tta agt cag gtc gat tcc tcc gtc ggc ggc aaa acc gcc432Thr Thr Leu Leu Ser Gln Val Asp Ser Ser Val Gly Gly Lys Thr Ala130 135 140atc aac cac ccg ctc ggc aaa aat atg atc ggc gcg ttc tac cag ccg480Ile Asn His Pro Leu Gly Lys Asn Met Ile Gly Ala Phe Tyr Gln Pro145 150 155 160cag gcg gtg ctt gcc gac ttg gac acg ctg cac acc ctg ccc gcc cgc528Gln Ala Val Leu Ala Asp Leu Asp Thr Leu His Thr Leu Pro Ala Arg165 170 175
gaa ctg tcc gcc ggt atg gcg gaa gtc atc aaa tac ggc acg ctc ggc576Glu Leu Ser Ala Gly Met Ala Glu Val Ile Lys Tyr Gly Thr Leu Gly180 185 190gac att agt ttt ttt gaa tgg ctg gaa cag cat atg ccc gaa ctg atg624Asp Ile Ser Phe Phe Glu Trp Leu Glu Gln His Met Pro Glu Leu Met195 200 205gca ctc gaa cgc gcg ccc ctc atc caa gcc gtg tac cgc tgt tgc caa672Ala Leu Glu Arg Ala Pro Leu Ile Gln Ala Val Tyr Arg Cys Cys Gln210 215 220atg aag gca gac atc gtc gcc caa gac gaa acc gaa cag ggc ata cgc720Met Lys Ala Asp Ile Val Ala Gln Asp Glu Thr Glu Gln Gly Ile Arg225 230 235 240gca tgg ctc aac ctc gga cac acc ttc gga cac gcc att gaa acc gag768Ala Trp Leu Asn Leu Gly His Thr Phe Gly His Ala Ile Glu Thr Glu245 250 255atg ggt tac ggt act tgg ctg cac ggc gag gcc gtc gcc gcc ggc tgc816Met Gly Tyr Gly Thr Trp Leu His Gly Glu Ala Val Ala Ala Gly Cys260 265 270gtg ttg gcg gcg cgt ttg tcc gaa caa ctg ggc aaa atc tcc gcc gca864Val Leu Ala Ala Arg Leu Ser Glu Gln Leu Gly Lys Ile Ser Ala Ala275 280 285gat acc gcg cgg ctc gcc gcc ctg ctc gaa gcc gcc gga ctg ccg tcc912Asp Thr Ala Arg Leu Ala Ala Leu Leu Glu Ala Ala Gly Leu Pro Ser290 295 300gcg cca ccc gtg ttt gcc ttt gaa aaa tgg ctg gaa cac atg agc cac960Ala Pro Pro Val Phe Ala Phe Glu Lys Trp Leu Glu His Met Ser His305 310 315 320gat aaa aaa gtc agc ggc ggc atc atg cgc ttt atc ggt ctg aac cgg1008Asp Lys Lys Val Ser Gly Gly Ile Met Arg Phe Ile Gly Leu Asn Arg325 330 335ctg ggc gaa gcc aac atc acc gaa att acc gac acg gac atc ctc cgc1056Leu Gly Glu Ala Asn Ile Thr Glu Ile Thr Asp Thr Asp Ile Leu Arg340 345 350cgc acc ctg caa ccg tat ctc1077Arg Thr Leu Gln Pro Tyr Leu355
<210>4<211>359<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>4Met Lys Thr Leu Thr Val His Thr Pro Ser His Ser Tyr Pro Ile Phe1 5 10 15Ile Gly Asn Gly Leu Leu Pro Gln Ala Gly Ser Leu Leu Lys Pro His20 25 30Leu Gly Lys Arg Ala Ala Ile Ile Thr Asn Glu Thr Val Ala Pro Leu35 40 45Tyr Leu Gly Thr Leu Gln Thr Ala Leu Asp Ala Ala Gly Val Ser His50 55 60Phe Ser Ile Ile Leu Pro Asp Gly Glu Ala His Lys Asn Trp Gln Thr65 70 75 80Leu Asn Leu Ile Phe Asp Gly Leu Met Gln Asn Arg Ala Glu Arg Lys85 90 95Thr Thr Leu Ile Ala Leu Gly Gly Gly Val Ile Gly Asp Met Thr Gly100 105 110Phe Ala Ala Ala Thr Tyr Gln Arg Gly Ala Pro Phe Val Gln Ile Pro115 120 125Thr Thr Leu Leu Ser Gln Val Asp Ser Ser Val Gly Gly Lys Thr Ala130 135 140Ile Asn His Pro Leu Gly Lys Asn Met Ile Gly Ala Phe Tyr Gln Pro145 150 155 160Gln Ala Val Leu Ala Asp Leu Asp Thr Leu His Thr Leu Pro Ala Arg165 170 175Glu Leu Ser Ala Gly Met Ala Glu Val Ile Lys Tyr Gly Thr Leu Gly180 185 190Asp Ile Ser Phe Phe Glu Trp Leu Glu Gln His Met Pro Glu Leu Met195 200 205Ala Leu Glu Arg Ala Pro Leu Ile Gln Ala Val Tyr Arg Cys Cys Gln210 215 220
Met Lys Ala Asp Ile Val Ala Gln Asp Glu Thr Glu Gln Gly Ile Arg225 230 235 240Ala Trp Leu Asn Leu Gly His Thr Phe Gly His Ala Ile Glu Thr Glu245 250 255Met Gly Tyr Gly Thr Trp Leu His Gly Glu Ala Val Ala Ala Gly Cys260 265 270Val Leu Ala Ala Arg Leu Ser Glu Gln Leu Gly Lys Ile Ser Ala Ala275 280 285Asp Thr Ala Arg Leu Ala Ala Leu Leu Glu Ala Ala Gly Leu Pro Ser290 295 300Ala Pro Pro Val Phe Ala Phe Glu Lys Trp Leu Glu His Met Ser His305 310 315 320Asp Lys Lys Val Ser Gly Gly Ile Met Arg Phe Ile Gly Leu Asn Arg325 330 335Leu Gly Glu Ala Asn Ile Thr Glu Ile Thr Asp Thr Asp Ile Leu Arg340 345 350Arg Thr Leu Gln Pro Tyr Leu355<210>5<211>1053<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1053)<400>5atg aca cac cat tac ccc aca gac gat att aag att aaa gaa gtt aaa48Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys1 5 10 15gag ttg ttg ccg ccg att gcc cat ctt tac gag ctg ccg att tcc aaa96Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys20 25 30
gag gct tcg ggc ttg gtt cac cgc acc cgt cag gaa att tcc gat ttg144Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu35 40 45gtt cac ggc agg gac aag cgg ctg ttg gtt att atc ggg ccg tgt tcg192Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser50 55 60att cac gat ccg aaa gcg gcg ttg gaa tat gcg gag cgt ttg ttg aaa240Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys65 70 75 80ctc cgc aag cag tat gaa aac gag ctt ttg att gtg atg cgc gtt tat288Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr85 90 95ttc gag aag ccg agg acg acg gtg ggt tgg aaa ggt ttg att aac gac336Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp100 105 110ccg cat ttg gac ggt acg ttt gac atc aat ttc ggt ttg cgt cag gca384Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala115 120 125cgc agc ctg ttg ttg tcg ctg aac aat atg ggt atg cct gcc tct acc432Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr130 135 140gag ttt ttg gat atg att acg ccg caa tat tat gcg gac ttg att tct480Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser145 150 155 160tgg ggg gca atc ggc gcg cgg acg acc gaa agc caa gtt cac cgc gaa528Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu165 170 175ttg gca agc ggg ctg tcc tgc ccc gtc ggc ttt aaa aac ggt acg gat576Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp180 185 190ggc aat ttg aag att gcc atc gac gca atc ggt gcg gcg agc cat tcg624Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser195 200 205cat cat ttc ctg tct gta acc aag gcc ggg cat tcc gcc att gtc cat672His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His210 215 220
acc ggc ggc aat cct gac tgt cat gtc att ttg cgc ggc gga aaa gag720Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu225 230 235 240ccg aat tat gat gcg gga cac gtc agc gag gcg gcg gaa caa ctg cgt768Pro Asn Tyr Asp Ala Gly His Val Ser Glu Ala Ala Glu Gln Leu Arg245 250 255gcg gca ggc gta acc gac aag ctg atg att gat tgc agc cac gcc aac816Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn260 265 270agc cgc aag gat tac acc cga cag atg gaa gtg gcg caa gac att gcc864Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala275 280 285gcc caa ttg gaa cag gac ggc ggc aat att atg ggc gtg atg gtg gaa912Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu290 295 300agc cat ttg gtc gaa ggc agg cag gac aag ccg gaa gtg tac ggc aaa960Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys305 310 315 320agc att acc gat gcg tgt att ggt tgg gac gcg act gaa gaa ctg ttg1008Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu325 330 335gca ttg ttg gca ggt gca aac aaa aaa cgt atg gcg cgc gcc ggt1053Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala Gly340 345 350<210>6<211>351<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>6Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys1 5 10 15Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys20 25 30Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu35 40 45
Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser50 55 60Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys65 70 75 80Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr85 90 95Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp100 105 110Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala115 120 125Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr130 135 140Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser145 150 155 160Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu165 170 175Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp180 185 190Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser195 200 205His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His210 215 220Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu225 230 235 240Pro Asn Tyr Asp Ala Gly His Val Ser Glu Ala Ala Glu Gln Leu Arg245 250 255Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn260 265 270Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala275 280 285Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu290 295 300
Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys305 310 315 320Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu325 330 335Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala Gly340 345 350<210>7<211>1686<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1686)<400>7atg tta caa tcc gaa aat tcg aaa aat tta atc tct tgt tca ata aag48Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys1 5 10 15gct tta cca atc atg att tct acc aac ggc atc acc atg cag ttc ggc96Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly20 25 30gcg aag ccg ctg ttt gaa aac gta tcc gtt aaa ttc ggc gaa ggc aac144Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn35 40 45cgc tac ggt ttg atc ggc gcg aac ggc tca ggc aaa tcc acc ttc atg192Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met50 55 60aaa atc ctc ggc ggc gat ttg gaa cag aca gcc ggc gaa gtg gcg att240Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile65 70 75 80gaa aac ggc gtg cgt ttg ggt aaa ttg cgc caa gac cag ttt gcc tac288Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr85 90 95gaa gat atg cgc gtg ctg gac gtg gta atg atg ggt cac acc gaa atg336Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met100 105 110
tgg gcg gcg atg acc gaa cgt gat gcg att tac gcc aat ccc gaa gcc384Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala115 120 125acc gaa gac gac tac atg aaa gcc gca gaa ctg gaa gcc aag ttc gcc432Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala130 135 140gaa tac gac ggc tac acc gcc gaa gcg cgt gcc gcc gag ttg ttg agc480Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser145 150 155 160ggc gtg ggc att tcc gaa gat ttg cac aat gca acc atg gca gaa gtt528Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val165 170 175gcc ccg ggc ttc aaa ctg cgc gta ttg ctg gcg caa gcc ctg ttc tcc576Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser180 185 190aag ccg gat gta ttg ctc ttg gac gaa ccg acc aat aac ttg gac att624Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile195 200 205aat acc atc cgt tgg ttg gaa ggc gtg ttg aac cag tac gac tcc acg672Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr210 215 220atg att atc atc tcg cac gac cgc cac ttc ttg aac gaa gtc tgc acg720Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr225 230 235 240cat atg gca gat ttg gat tac aac acc atc acc atc tat ccg ggc aac768His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn245 250 255tac gac gac tat atg ctc gcc tcc gcc caa tcg cgc gaa cgc gcc ctg816Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu260 265 270aaa gac aat gcc aag gcg aag gaa aaa ttg cag gaa ttg caa gaa ttt864Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe275 280 285gtg gcg cgg ttc agt gcc aac aaa tcc aaa gcc cgt cag gca acc agc912Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser290 295 300
cgt ctg aaa cag gca gac aaa atc aaa tcg gag atg gtc gag gtc aaa960Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys305 310 315 320ccc tct acc cgt caa aac ccg tat atc cgt ttt gaa gcc gat gaa aaa1008Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys325 330 335gcc aag ctg cac cgt cag gct gtg gaa gtt gaa aaa ctg gcg aaa cgc1056Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg340 345 350ttt gaa acc cag ttg ttt aaa aac ctg aac ttt atc ctt gaa gcg gga1104Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly355 360 365caa cgc ctc gcc atc atc ggc ccg aac ggc gcg ggc aaa tcc acc ctg1152Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu370 375 380ctg aaa ctc ttg gcc ggc gcg tac aac ccc gaa tat tca gac ggt ctg1200Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu385 390 395 400ctg ccg gac gaa ggc agc atc aaa tgg gcg gaa aaa gcc agc gtc ggc1248Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly405 410 415tac tat ccg caa gat cac gaa aac gac ttc gat gtc gat atg gat ttg1296Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu420 425 430agc gaa tgg atg cgc caa tgg ggg cag gac ggc gac gac gaa caa gtc1344Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val435 440 445atc cgc ggc act ttg ggg cgt ttg ctc ttc ggc agt aac gat gtc gtg1392Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val450 455 460aaa aaa gtg aag gtt ctc tcc ggt ggt gaa aaa ggc cgt atg ctt tac1440Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr465 470 475 480ggc aaa ctg ttg ctg ttg aaa ccc aat gtc tta gtc atg gat gaa ccg1488Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro485 490 495
acc aac cac atg gac atg gaa agc atc gaa tcc ttg aac atg gcg ctg1536Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu500 505 510gaa aaa tac aac ggc acg ctg att ttc gtc tcc cac gac cgt cag ttc1584Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe515 520 525gtt tct tcc ctg gct acc caa atc att gaa ttg gac ggc aaa ggc gga1632Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly530 535 540tat gaa cac tac ttg ggc gat tac gaa agc tat ctc gag aaa aaa ggc1680Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly545 550 555 560gta gca1686Val Ala<210>8<211>562<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>8Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys1 5 10 15Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly20 25 30Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn35 40 45Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met50 55 60Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile65 70 75 80Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr85 90 95Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met100 105 110
Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala115 120 125Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala130 135 140Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser145 150 155 160Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val165 170 175Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser180 185 190Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile195 200 205Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr210 215 220Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr225 230 235 240His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn245 250 255Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu260 265 270Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe275 280 285Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser290 295 300Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys305 310 315 320Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys325 330 335Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg340 345 350Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly355 360 365
Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu370 375 380Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu385 390 395 400Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly405 410 415Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu420 425 430Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val435 440 445Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val450 455 460Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr465 470 475 480Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro485 490 495Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu500 505 510Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe515 520 525Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly530 535 540Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly545 550 555 560Val Ala<210>9<211>1632<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS
<222>(1)..(1632)<400>9atg ata aaa ccg aac ctg agg ccg aag ctc ggc tct tcc gcg ctg att48Met Ile Lys Pro Asn Leu Arg Pro Lys Leu Gly Ser Ser Ala Leu Ile1 5 10 15gcc ttc ctt tcc ctg tat tcc tcg ctg gta ttg aat tac gcc ttt ttt96Ala Phe Leu Ser Leu Tyr Ser Ser Leu Val Leu Asn Tyr Ala Phe Phe20 25 30gcc aaa gtt gtc gag ctt cat cct ttt aac ggc acc ggg gcg gat atc144Ala Lys Val Val Glu Leu His Pro Phe Asn Gly Thr Gly Ala Asp Ile35 40 45ttc ctc tat acg atg ccg gtg gtg ctg ttt ttt tta agt aat ttc gtt192Phe Leu Tyr Thr Met Pro Val Val Leu Phe Phe Leu Ser Asn Phe Val50 55 60ttt cac gtc att gcc ctg cct ttc gtg cat aag gta ttg att ccg ttg240Phe His Val Ile Ala Leu Pro Phe Val His Lys Val Leu Ile Pro Leu65 70 75 80ata ttg gtt atc agt gcg gcg gtg tct tac caa gaa ata ttt ttc aat288Ile Leu Val Ile Ser Ala Ala Val Ser Tyr Gln Glu Ile Phe Phe Asn85 90 95atc tat ttc aac aag tcg atg ttg aat aat gtc ttg caa act acg gct336Ile Tyr Phe Asn Lys Ser Met Leu Asn Asn Val Leu Gln Thr Thr Ala100 105 110gcc gaa agc gcg cgc ctg att acg ccg ggc tat gtg ctg tgg att gta384Ala Glu Ser Ala Arg Leu Ile Thr Pro Gly Tyr Val Leu Trp Ile Val115 120 125tgt ttg ggc gta ttg ccc gcg ctg gcg tat atc gcc gtc aag gtt aaa432Cys Leu Gly Val Leu Pro Ala Leu Ala Tyr Ile Ala Val Lys Val Lys130 135 140tac cgc gtt tgg tat aag gag ctt ttg acg cgc ctt gtg ctt gcc gcc480Tyr Arg Val Trp Tyr Lys Glu Leu Leu Thr Arg Leu Val Leu Ala Ala145 150 155 160gtt tcc ttt ttg tgc gcg ttg ggc atc gca atg ttg caa tat cag gat528Val Ser Phe Leu Cys Ala Leu Gly Ile Ala Met Leu Gln Tyr Gln Asp165 170 175tac gcc tcg ttt ttc cgc aac aat aaa tca gta acc cat ctg att gtg576
Tyr Ala Ser Phe Phe Arg Asn Asn Lys Ser Val Thr His Leu Ile Val180 185 190cca tct aat ttc atc ggc gcg ggc gtg tcg aaa tac aaa gat tgg aag624Pro Ser Asn Phe Ile Gly Ala Gly Val Ser Lys Tyr Lys Asp Trp Lys195 200 205cgt tcc aat att cct tat acg caa ttg gat atg gcg gtc gtg caa aac672Arg Ser Asn Ile Pro Tyr Thr Gln Leu Asp Met Ala Val Val Gln Asn210 215 220cgc ccg gcc ggc agc ctg cgc cgt ttc gtg gtg ctg gtc gtg ggc gag720Arg Pro Ala Gly Ser Leu Arg Arg Phe Val Val Leu Val Val Gly Glu225 230 235 240acc acg cgt gcc gcc aac tgg ggt ttg aac ggt tac agc cgc caa act768Thr Thr Arg Ala Ala Asn Trp Gly Leu Asn Gly Tyr Ser Arg Gln Thr245 250 255acg ccg ctg ctt gcc gcg cgc ggc gat gaa att gtc aat ttc ccg cag816Thr Pro Leu Leu Ala Ala Arg Gly Asp Glu Ile Val Asn Phe Pro Gln260 265 270gtc aga agc tgc ggt aca tcg acc gcg cac tcc ctg ccg tgt atg ttc864Val Arg Ser Cys Gly Thr Ser Thr Ala His Ser Leu Pro Cys Met Phe275 280 285tca acc ttc gac cgc acg gat tat gac gaa atc aaa gcc gaa cac caa912Ser Thr Phe Asp Arg Thr Asp Tyr Asp Glu Ile Lys Ala Glu His Gln290 295 300gac aac ctg ctg gac atc gtg cag cgc gcc ggc gtg gaa gtt acc tgg960Asp Asn Leu Leu Asp Ile Val Gln Arg Ala Gly Val Glu Val Thr Trp305 310 315 320ttg gaa aac gat tcc ggc tgc aag ggc gtg tgc ggc aaa gtg ccg aat1008Leu Glu Asn Asp Ser Gly Cys Lys Gly Val Cys Gly Lys Val Pro Asn325 330 335acc gac gtt acc tcg ctc aac ctg ccc gaa tac tgc cgc aac ggc gag1056Thr Asp Val Thr Ser Leu Asn Leu Pro Glu Tyr Cys Arg Asn Gly Glu340 345 350tgc ctc gac aat atc ctg ctg acc aag ttc gac gaa gtc ctc aac aaa1104Cys Leu Asp Asn Ile Leu Leu Thr Lys Phe Asp Glu Val Leu Asn Lys355 360 365aac gat aaa gac gcg gtt tta atc ctg cat acc atc ggc agc cac ggg1152
Asn Asp Lys Asp Ala Val Leu Ile Leu His Thr Ile Gly Ser His Gly370 375 380ccg acg tat tac gaa cgc tat acc gaa gcc gaa cgc aaa ttc acg ccg1200Pro Thr Tyr Tyr Glu Arg Tyr Thr Glu Ala Glu Arg Lys Phe Thr Pro385 390 395 400acc tgc gac acc aac gaa atc aac aaa tgc acc cgc gcc acg ctg gtc1248Thr Cys Asp Thr Asn Glu Ile Asn Lys Cys Thr Arg Ala Thr Leu Val405 410 415aac act tac gac aat acg gtt ttg tat gtg gac cag ttt atc gac aag1296Asn Thr Tyr Asp Asn Thr Val Leu Tyr Val Asp Gln Phe Ile Asp Lys420 425 430gtt atc cgc aaa ctt gaa aac cgc gac gat ttg gaa agc gtg gtg cat1344Val Ile Arg Lys Leu Glu Asn Arg Asp Asp Leu Glu Ser Val Val His435 440 445tat gtt tcc gac cac ggc gaa agt ttg ggc gaa aac ggg atg tac ctg1392Tyr Val Ser Asp His Gly Glu Ser Leu Gly Glu Asn Gly Met Tyr Leu450 455 460cac gcc gcg cct tac gcc atc gcg cct tcc ggg cag acg cat atc ccg1440His Ala Ala Pro Tyr Ala Ile Ala Pro Ser Gly Gln Thr His Ile Pro465 470 475 480atg gtt atg tgg ttt tcc aaa gcc ttc cgc caa cac ggg ggc ata gat1488Met Val Met Trp Phe Ser Lys Ala Phe Arg Gln His Gly Gly Ile Asp485 490 495ttc caa tgc ctc aaa caa aaa gcg gcg gaa aac gaa tat tcg cac gac1536Phe Gln Cys Leu Lys Gln Lys Ala Ala Glu Asn Glu Tyr Ser His Asp500 505 510cac tat ttc agc acg gta ttg ggg ctg atg gac att tcc aac agc caa1584His Tyr Phe Ser Thr Val Leu Gly Leu Met Asp Ile Ser Asn Ser Gln515 520 525acc tat cgg aag gaa atg gat ata ttg gca gcc tgc cgc cgt ccg cgc1632Thr Tyr Arg Lys Glu Met Asp Ile Leu Ala Ala Cys Arg Arg Pro Arg530 535 540<210>10<211>544<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)
<400>10Met Ile Lys Pro Asn Leu Arg Pro Lys Leu Gly Ser Ser Ala Leu Ile1 5 10 15Ala Phe Leu Ser Leu Tyr Ser Ser Leu Val Leu Asn Tyr Ala Phe Phe20 25 30Ala Lys Val Val Glu Leu His Pro Phe Asn Gly Thr Gly Ala Asp Ile35 40 45Phe Leu Tyr Thr Met Pro Val Val Leu Phe Phe Leu Ser Asn Phe Val50 55 60Phe His Val Ile Ala Leu Pro Phe Val His Lys Val Leu Ile Pro Leu65 70 75 80Ile Leu Val Ile Ser Ala Ala Val Ser Tyr Gln Glu Ile Phe Phe Asn85 90 95Ile Tyr Phe Asn Lys Ser Met Leu Asn Asn Val Leu Gln Thr Thr Ala100 105 110Ala Glu Ser Ala Arg Leu Ile Thr Pro Gly Tyr Val Leu Trp Ile Val115 120 125Cys Leu Gly Val Leu Pro Ala Leu Ala Tyr Ile Ala Val Lys Val Lys130 135 140Tyr Arg Val Trp Tyr Lys Glu Leu Leu Thr Arg Leu Val Leu Ala Ala145 150 155 160Val Ser Phe Leu Cys Ala Leu Gly Ile Ala Met Leu Gln Tyr Gln Asp165 170 175Tyr Ala Ser Phe Phe Arg Asn Asn Lys Ser Val Thr His Leu Ile Val180 185 190Pro Ser Asn Phe Ile Gly Ala Gly Val Ser Lys Tyr Lys Asp Trp Lys195 200 205Arg Ser Asn Ile Pro Tyr Thr Gln Leu Asp Met Ala Val Val Gln Asn210 215 220Arg Pro Ala Gly Ser Leu Arg Arg Phe Val Val Leu Val Val Gly Glu225 230 235 240Thr Thr Arg Ala Ala Asn Trp Gly Leu Asn Gly Tyr Ser Arg Gln Thr
245 250 255Thr Pro Leu Leu Ala Ala Arg Gly Asp Glu Ile Val Asn Phe Pro Gln260 265 270Val Arg Ser Cys Gly Thr Ser Thr Ala His Ser Leu Pro Cys Met Phe275 280 285Ser Thr Phe Asp Arg Thr Asp Tyr Asp Glu Ile Lys Ala Glu His Gln290 295 300Asp Asn Leu Leu Asp Ile Val Gln Arg Ala Gly Val Glu Val Thr Trp305 310 315 320Leu Glu Asn Asp Ser Gly Cys Lys Gly Val Cys Gly Lys Val Pro Asn325 330 335Thr Asp Val Thr Ser Leu Asn Leu Pro Glu Tyr Cys Arg Asn Gly Glu340 345 350Cys Leu Asp Asn Ile Leu Leu Thr Lys Phe Asp Glu Val Leu Asn Lys355 360 365Asn Asp Lys Asp Ala Val Leu Ile Leu His Thr Ile Gly Ser His Gly370 375 380Pro Thr Tyr Tyr Glu Arg Tyr Thr Glu Ala Glu Arg Lys Phe Thr Pro385 390 395 400Thr Cys Asp Thr Asn Glu Ile Asn Lys Cys Thr Arg Ala Thr Leu Val405 410 415Asn Thr Tyr Asp Asn Thr Val Leu Tyr Val Asp Gln Phe Ile Asp Lys420 425 430Val Ile Arg Lys Leu Glu Asn Arg Asp Asp Leu Glu Ser Val Val His435 440 445Tyr Val Ser Asp His Gly Glu Ser Leu Gly Glu Asn Gly Met Tyr Leu450 455 460His Ala Ala Pro Tyr Ala Ile Ala Pro Ser Gly Gln Thr His Ile Pro465 470 475 480Met Val Met Trp Phe Ser Lys Ala Phe Arg Gln His Gly Gly Ile Asp485 490 495Phe Gln Cys Leu Lys Gln Lys Ala Ala Glu Asn Glu Tyr Ser His Asp
500 505 510His Tyr Phe Ser Thr Val Leu Gly Leu Met Asp Ile Ser Asn Ser Gln515 520 525Thr Tyr Arg Lys Glu Met Asp Ile Leu Ala Ala Cys Arg Arg Pro Arg530 535 540<210>11<211>1052<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1050)<400>11atg aca cac cat tac ccc aca gac gat att aag att aaa gaa gtt aaa48Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys1 5 10 15gag ttg ttg ccg ccg att gcc cat ctt tac gag ctg ccg att tcc aaa96Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys20 25 30gag gct tcg ggc ttg gtt cac cgc acc cgt cag gaa att tcc gat ttg144Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu35 40 45gtt cac ggc agg gac aag cgg ctg ttg gtt att atc ggg ccg tgt tcg192Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser50 55 60att cac gat ccg aaa gcg gcg ttg gaa tat gcg gag cgt ttg ttg aaa240Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys65 70 75 80ctc cgc aag cag tat gaa aac gag ctt ttg att gtg atg cgc gtt tat288Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr85 90 95ttc gag aag ccg agg acg acg gtg ggt tgg aaa ggt ttg att aac gac336Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp100 105 110
ccg cat ttg gac ggt acg ttt gac atc aat ttc ggt ttg cgt cag gca384Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala115 120 125cgc agc ctg ttg ttg tcg ctg aac aat atg ggt atg cct gcc tct acc432Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr130 135 140gag ttt ttg gat atg att acg ccg caa tat tat gcg gac ttg att tct480Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser145 150 155 160tgg ggg gca atc ggc gcg cgg acg acc gaa agc caa gtt cac cgc gaa528Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu165 170 175ttg gca agc ggg ctg tcc tgc ccc gtc ggc ttt aaa aac ggt acg gat576Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp180 185 190ggc aat ttg aag att gcc atc gac gca atc ggt gcg gcg agc cat tcg624Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser195 200 205cat cat ttc ctg tct gta acc aag gcc ggg cat tcc gcc att gtc cat672His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His210 215 220acc ggc ggc aat cct gac tgt cat gtc att ttg cgc ggc gga aaa gag720Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu225 230 235 240ccg aat tat gat gcg gga cac gtc agc gag gcg gcg gaa caa ctg cgt768Pro Asn Tyr Asp Ala Gly His Val Ser Glu Ala Ala Glu Gln Leu Arg245 250 255gcg gca ggc gta acc gac aag ctg atg att gat tgc agc cac gcc aac816Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn260 265 270agc cgc aag gat tac acc cga cag atg gaa gtg gcg caa gac att gcc864Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala275 280 285gcc caa ttg gaa cag gac ggc ggc aat att atg ggc gtg atg gtg gaa912Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu290 295 300
agc cat ttg gtc gaa ggc agg cag gac aag ccg gaa gtg tac ggc aaa960Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys305 310 315 320agc att acc gat gcg tgt att ggt tgg gac gcg act gaa gaa ctg ttg1008Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu325 330 335gca ttg ttg gca ggt gca aac aaa aaa cgt atg gcg cgc gcc gg 1052Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala340 345 350<210>12<211>350<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>12Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys1 5 10 15Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys20 25 30Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu35 40 45Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser50 55 60Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys65 70 75 80Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr85 90 95Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp100 105 110Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala115 120 125Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr130 135 140Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser145 150 155 160
Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu165 170 175Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp180 185 190Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser195 200 205His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His210 215 220Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu225 230 235 240Pro Asn Tyr Asp Ala Gly His Val ser Glu Ala Ala Glu Gln Leu Arg245 250 255Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn260 265 270Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala275 280 285Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu290 295 300Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys305 310 315 320Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu325 330 335Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala340 345 350<210>13<211>432<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(432)
<400>13atg gca ttt ggt tcg atg aat tcc ggc gac gat tct ccg atg tcc gac48Met Ala Phe Gly Ser Met Asn Ser Gly Asp Asp Ser Pro Met Ser Asp1 5 10 15atc aac gtt acg ccg ttg gtg gac gtg atg ctg gtg ttg ctg att gtg96Ile Asn Val Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ile Val20 25 30ttt atg att act atg ccg gtg ctg acg cat tcc atc cct ttg gaa ctg144Phe Met Ile Thr Met Pro Val Leu Thr His Ser Ile Pro Leu Glu Leu35 40 45ccg acc gcg tcc gag cag aca aac aag cag gac aaa cag cct aaa gac192Pro Thr Ala Ser Glu Gln Thr Asn Lys Gln Asp Lys Gln Pro Lys Asp50 55 60ccc ctg cgc ctg acg att gat gcg aac ggc ggc tat tat gtc ggc ggg240Pro Leu Arg Leu Thr Ile Asp Ala Asn Gly Gly Tyr Tyr Val Gly Gly65 70 75 80gat tct gca agc aaa gtg gaa atc ggg gaa gtg gaa agc cgt ctg aaa288Asp Ser Ala Ser Lys Val Glu Ile Gly Glu Val Glu Ser Arg Leu Lys85 90 95gcc gcc aag gag cag aat gaa aac gtg att gtg gcg att gcg gca gac336Ala Ala Lys Glu Gln Asn Glu Asn Val Ile Val Ala Ile Ala Ala Asp100 105 110aag gcg gtg gaa tac gat tat gta aac aaa gct tta gaa gcc gcc cgt384Lys Ala Val Glu Tyr Asp Tyr Val Asn Lys Ala Leu Glu Ala Ala Arg115 120 125cag gca gga atc acc aaa atc ggt ttt gta acc gaa acc aag gcg caa432Gln Ala Gly Ile Thr Lys Ile Gly Phe Val Thr Glu Thr Lys Ala Gln130 135 140<210>14<211>144<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>14Met Ala Phe Gly Ser Met Asn Ser Gly Asp Asp Ser Pro Met Ser Asp1 5 10 15Ile Asn Val Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ile Val
20 25 30Phe Met Ile Thr Met Pro Val Leu Thr His Ser Ile Pro Leu Glu Leu35 40 45Pro Thr Ala Ser Glu Gln Thr Asn Lys Gln Asp Lys Gln Pro Lys Asp50 55 60Pro Leu Arg Leu Thr Ile Asp Ala Asn Gly Gly Tyr Tyr Val Gly Gly65 70 75 80Asp Ser Ala Ser Lys Val Glu Ile Gly Glu Val Glu Ser Arg Leu Lys85 90 95Ala Ala Lys Glu Gln Asn Glu Asn Val Ile Val Ala Ile Ala Ala Asp100 105 110Lys Ala Val Glu Tyr Asp Tyr Val Asn Lys Ala Leu Glu Ala Ala Arg115 120 125Gln Ala Gly Ile Thr Lys Ile Gly Phe Val Thr Glu Thr Lys Ala Gln130 135 140<210>15<211>267<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(267)<400>15atg ctc aaa caa tcc atc gaa atc atc aac aaa ctc gga ctc cac gcc48Met Leu Lys Gln Ser Ile Glu Ile Ile Asn Lys Leu Gly Leu His Ala1 5 10 15cgc gcg tcc aac aag ttc acc caa acc gcg tcc caa ttc aaa agc gaa96Arg Ala Ser Asn Lys Phe Thr Gln Thr Ala Ser Gln Phe Lys Ser Glu20 25 30gtc tgg gtt acg aaa aac gac agc cgc gtc aac ggc aaa agc att atg144Val Trp Val Thr Lys Asn Asp Ser Arg Val Asn Gly Lys Ser Ile Met35 40 45ggg ctg atg atg ctc gcc gcc gcc aag ggt acg gtc atc gaa ctg gag192
Gly Leu Met Met Leu Ala Ala Ala Lys Gly Thr Val Ile Glu Leu Glu50 55 60acg gac ggc gcg gac gag gcg gaa gcg atg cgc gcc ctg acc gac tta240Thr Asp Gly Ala Asp Glu Ala Glu Ala Met Arg Ala Leu Thr Asp Leu65 70 75 80atc aac ggc tac ttc ggc gag ggc gaa267Ile Asn Gly Tyr Phe Gly Glu Gly Glu85<210>16<211>89<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>16Met Leu Lys Gln Ser Ile Glu Ile Ile Asn Lys Leu Gly Leu His Ala1 5 10 15Arg Ala Ser Asn Lys Phe Thr Gln Thr Ala Ser Gln Phe Lys Ser Glu20 25 30Val Trp Val Thr Lys Asn Asp Ser Arg Val Asn Gly Lys Ser Ile Met35 40 45Gly Leu Met Met Leu Ala Ala Ala Lys Gly Thr Val Ile Glu Leu Glu50 55 60Thr Asp Gly Ala Asp Glu Ala Glu Ala Met Arg Ala Leu Thr Asp Leu65 70 75 80Ile Asn Gly Tyr Phe Gly Glu Gly Glu85<210>17<211>633<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(633)<400>17
atg ccc atg aac ctt ttt caa aac gcc aaa ttc ttc acg acg gta aac48Met Pro Met Asn Leu Phe Gln Asn Ala Lys Phe Phe Thr Thr Val Asn1 5 10 15cat ctc aaa gac ctg ccg gac aca ccg ctc gaa att gcc ttt gtc ggc96His Leu Lys Asp Leu Pro Asp Thr Pro Leu Glu Ile Ala Phe Val Gly20 25 30agg agc aat gcc gga aaa tcc agt gcc atc aat acc ctg acc aac cat144Arg Ser Asn Ala Gly Lys Ser Ser Ala Ile Asn Thr Leu Thr Asn His35 40 45gtc cgt ctt gcc tac gtt tca aaa aca ccc gga cgg acg cag cat atc192Val Arg Leu Ala Tyr Val Ser Lys Thr Pro Gly Arg Thr Gln His Ile50 55 60aac ttc ttc gag ctg cag aac ggc aat ttt atg gtc gat ttg ccc ggc240Asn Phe Phe Glu Leu Gln Asn Gly Asn Phe Met Val Asp Leu Pro Gly65 70 75 80tac ggt tat gcc caa gtc ccc gaa gca gta cgc gca cat tgg gtc aat288Tyr Gly Tyr Ala Gln Val Pro Glu Ala Val Arg Ala His Trp Val Asn85 90 95ctg ctc ggc gac tat ctg caa cag cgc aaa cag ctt atc ggg ctg gtt336Leu Leu Gly Asp Tyr Leu Gln Gln Arg Lys Gln Leu Ile Gly Leu Val100 105 110ttg att atg gat gcc cgc cat cct tta aaa gaa ctc gac atc cgt atg384Leu Ile Met Asp Ala Arg His Pro Leu Lys Glu Leu Asp Ile Arg Met115 120 125ctg gac ttt ttc cac acg acc ggc aga ccg gtt cac atc ctg ctg tca432Leu Asp Phe Phe His Thr Thr Gly Arg Pro Val His Ile Leu Leu Ser130 135 140aaa gcc gac aaa tta tcc aaa aac gaa cag ata aaa acc ctg tcc caa480Lys Ala Asp Lys Leu Ser Lys Asn Glu Gln Ile Lys Thr Leu Ser Gln145 150 155 160gtc aaa aaa ctg ctc aaa cct tat tcc gac agg caa aac atc agc gta528Val Lys Lys Leu Leu Lys Pro Tyr Ser Asp Arg Gln Asn Ile Ser Val165 170 175cag ctg ttt tcc agc ctg aaa aaa caa ggt att gac gag gcc aac cga576Gln Leu Phe Ser Ser Leu Lys Lys Gln Gly Ile Asp Glu Ala Asn Arg180 185 190
act gtc gga agc tgg ttt gac gca gca gat gcc gcc gct tcc tct cca624Thr Val Gly Ser Trp Phe Asp Ala Ala Asp Ala Ala Ala Ser Ser Pro195 200 205aag gaa aac633Lys Glu Asn210<210>18<211>211<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>18Met Pro Met Asn Leu Phe Gln Asn Ala Lys Phe Phe Thr Thr Val Asn1 5 10 15His Leu Lys Asp Leu Pro Asp Thr Pro Leu Glu Ile Ala Phe Val Gly20 25 30Arg Ser Asn Ala Gly Lys Ser Ser Ala Ile Asn Thr Leu Thr Asn His35 40 45Val Arg Leu Ala Tyr Val Ser Lys Thr Pro Gly Arg Thr Gln His Ile50 55 60Asn Phe Phe Glu Leu Gln Asn Gly Asn Phe Met Val Asp Leu Pro Gly65 70 75 80Tyr Gly Tyr Ala Gln Val Pro Glu Ala Val Arg Ala His Trp Val Asn85 90 95Leu Leu Gly Asp Tyr Leu Gln Gln Arg Lys Gln Leu Ile Gly Leu Val100 105 110Leu Ile Met Asp Ala Arg His Pro Leu Lys Glu Leu Asp Ile Arg Met115 120 125Leu Asp Phe Phe His Thr Thr Gly Arg Pro Val His Ile Leu Leu Ser130 135 140Lys Ala Asp Lys Leu Ser Lys Asn Glu Gln Ile Lys Thr Leu Ser Gln145 150 155 160Val Lys Lys Leu Leu Lys Pro Tyr Ser Asp Arg GLn Asn Ile Ser Val165 170 175
Gln Leu Phe Ser Ser Leu Lys Lys Gln Gly Ile Asp Glu Ala Asn Arg180 185 190Thr Val Gly Ser Trp Phe Asp Ala Ala Asp Ala Ala Ala Ser Ser Pro195 200 205Lys Glu Asn210<210>19<211>621<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(621)<400>19atg aaa cga ttg act tta ttg gcc ttt gtt ttg gct gcc ggt gcg gtt48Met Lys Arg Leu Thr Leu Leu Ala Phe Val Leu Ala Ala Gly Ala Val1 5 10 15tcc gca tct ccc aaa gca gac gtg gaa aaa ggc aaa cag gtt gcc gca96Ser Ala Ser Pro Lys Ala Asp Val Glu Lys Gly Lys Gln Val Ala Ala20 25 30acg gtt tgt gcg gct tgc cat gca gca gac ggt aac agc ggc att gcg144Thr Val Cys Ala Ala Cys His Ala Ala Asp Gly Asn Ser Gly Ile Ala35 40 45atg tat ccg cgt ttg gcg gca cag cat act gct tac atc tat cat caa192Met Tyr Pro Arg Leu Ala Ala Gln His Thr Ala Tyr Ile Tyr His Gln50 55 60acc atc ggc atc cgc gac ggt aaa cgc acc cac ggt tcg gca gct gtg240Thr Ile Gly Ile Arg Asp Gly Lys Arg Thr His Gly Ser Ala Ala Val65 70 75 80atg aaa ccg gtg gta atg aat ttg agc gat cag gat att ttg aac gta288Met Lys Pro Val Val Met Asn Leu Ser Asp Gln Asp Ile Leu Asn Val85 90 95tcc gca ttc tat gcc aaa cag cag ccc aaa tcc ggt gaa gcc aat cct336Ser Ala Phe Tyr Ala Lys Gln Gln Pro Lys Ser Gly Glu Ala Asn Pro100 105 110
aag gaa aat ccc gaa ttg ggt gcg aaa atc tat cgc ggc ggt ttg agc384Lys Glu Asn Pro Glu Leu Gly Ala Lys Ile Tyr Arg Gly Gly Leu Ser115 120 125gat aaa aaa gtg ccg gcg tgt atg tcc tgc cac ggt ccg agc ggt gcg432Asp Lys Lys Val Pro Ala Cys Met Ser Cys His Gly Pro Ser Gly Ala130 135 140ggt atg ccg ggg ggc gga agc gaa att cag gct tat ccg cgt ttg ggc480Gly Met Pro Gly Gly Gly Ser Glu Ile Gln Ala Tyr Pro Arg Leu Gly145 150 155 160ggt cag cat cag gca tat att gtt gaa cag atg aat gcc tac aag tcc528Gly Gln His Gln Ala Tyr Ile Val Glu Gln Met Asn Ala Tyr Lys Ser165 170 175ggt cag cgt aaa aat acc atc atg gaa gat att gca aac cgt atg tct576Gly Gln Arg Lys Asn Thr Ile Met Glu Asp Ile Ala Asn Arg Met Ser180 185 190gaa gaa gat ttg aaa gcg gtc gcc aac ttt atc caa ggt ttg cgt621Glu Glu Asp Leu Lys Ala Val Ala Asn Phe Ile Gln Gly Leu Arg195 200 205<210>20<211>207<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>20Met Lys Arg Leu Thr Leu Leu Ala Phe Val Leu Ala Ala Gly Ala Val1 5 10 15Ser Ala Ser Pro Lys Ala Asp Val Glu Lys Gly Lys Gln Val Ala Ala20 25 30Thr Val Cys Ala Ala Cys His Ala Ala Asp Gly Asn Ser Gly Ile Ala35 40 45Met Tyr Pro Arg Leu Ala Ala Gln His Thr Ala Tyr Ile Tyr His Gln50 55 60Thr Ile Gly Ile Arg Asp Gly Lys Arg Thr His Gly Ser Ala Ala Val65 70 75 80Met Lys Pro Val Val Met Asn Leu Ser Asp Gln Asp Ile Leu Asn Val
85 90 95Ser Ala Phe Tyr Ala Lys Gln Gln Pro Lys Ser Gly Glu Ala Asn Pro100 105 110Lys Glu Asn Pro Glu Leu Gly Ala Lys Ile Tyr Arg Gly Gly Leu Ser115 120 125Asp Lys Lys Val Pro Ala Cys Met Ser Cys His Gly Pro Ser Gly Ala130 135 140Gly Met Pro Gly Gly Gly Ser Glu Ile Gln Ala Tyr Pro Arg Leu Gly145 150 155 160Gly Gln His Gln Ala Tyr Ile Val Glu Gln Met Asn Ala Tyr Lys Ser165 170 175Gly Gln Arg Lys Asn Thr Ile Met Glu Asp Ile Ala Asn Arg Met Ser180 185 190Glu Glu Asp Leu Lys Ala Val Ala Asn Phe Ile Gln Gly Leu Arg195 200 205<210>21<211>765<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(765)<400>2latg ccg tct gaa gcc cga ttt ttc agg ctt cag acg gca ttt ccc cgt48Met Pro Ser Glu Ala Arg Phe Phe Arg Leu Gln Thr Ala Phe Pro Arg1 5 10 15ttg att tgc ggt ata atc cgc ctt tac cca ttg ttt gca aag cac aat96Leu Ile Cys Gly Ile Ile Arg Leu Tyr Pro Leu Phe Ala Lys His Asn20 25 30atg aca cgc aaa atc ctc gtt acc tcc gcc ctg ccc tat gcc aac ggc144Met Thr Arg Lys Ile Leu Val Thr Ser Ala Leu Pro Tyr Ala Asn Gly35 40 45agc atc cac ctc ggc cac atg gtc gaa cac atc caa acc gac gtt tgg192
Ser Ile His Leu Gly His Met Val Glu His Ile Gln Thr Asp Val Trp50 55 60gtg cgc ttt caa aaa ctg cgc ggc aac gaa tgc cac tac tgc tgc gcc240Val Arg Phe Gln Lys Leu Arg Gly Asn Glu Cys His Tyr Cys Cys Ala65 70 75 80gac gac acc cac ggc acg ccc gtg atg ctt gcc gcg caa aaa caa ggc288Asp Asp Thr His Gly Thr Pro Val Met Leu Ala Ala Gln Lys Gln Gly85 90 95atc gcg ccc gaa gac atg att gcc aaa gtg cgc gaa gag cac ctc gcc336Ile Ala Pro Glu Asp Met Ile Ala Lys Val Arg Glu Glu His Leu Ala100 105 110gac ttt act ggc ttt ttc atc ggt tac gac aat tat tac agc acc cat384Asp Phe Thr Gly Phe Phe Ile Gly Tyr Asp Asn Tyr Tyr Ser Thr His115 120 125tcc cct gaa aac aaa cag ttt tcc caa gac att tac cgc gcg ctg aaa432Ser Pro Glu Asn Lys Gln Phe Ser Gln Asp Ile Tyr Arg Ala Leu Lys130 135 140gcc aac ggc aag att gag agc cgc gtc atc gag cag ctt ttc gac ccc480Ala Asn Gly Lys Ile Glu Ser Arg Val Ile Glu Gln Leu Phe Asp Pro145 150 155 160gaa aaa caa atg ttc ctg ccc gac cgc ttc gtt aaa ggc gaa tgc ccg528Glu Lys Gln Met Phe Leu Pro Asp Arg Phe Val Lys Gly Glu Cys Pro165 170 175aaa tgc cac gcc caa gac caa tac ggc gac aac tgc gaa gtc tgc ggc576Lys Cys His Ala Gln Asp Gln Tyr Gly Asp Asn Cys Glu Val Cys Gly180 185 190acg acc tat tcc ccg acc gaa ctg att aac ccg tat tcc gcc gtt tcc624Thr Thr Tyr Ser Pro Thr Glu Leu Ile Asn Pro Tyr Ser Ala Val Ser195 200 205ggc gcg aaa ccc gaa ttg cgc gaa tcc gaa cac ttc ttc ttc aaa ctg672Gly Ala Lys Pro Glu Leu Arg Glu Ser Glu His Phe Phe Phe Lys Leu210 215 220gga gaa tgc gcc gac ttc ctc aaa gca tgg act tcc ggc aac aac ccg720Gly Glu Cys Ala Asp Phe Leu Lys Ala Trp Thr Ser Gly Asn Asn Pro225 230 235 240cac gac ggc aag ccc cat ctg caa gcc gaa gcc ctc aac aaa atg765
His Asp Gly Lys Pro His Leu Gln Ala Glu Ala Leu Asn Lys Met245 250 255<210>22<211>255<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>22Met Pro Ser Glu Ala Arg Phe Phe Arg Leu Gln Thr Ala Phe Pro Arg1 5 10 15Leu Ile Cys Gly Ile Ile Arg Leu Tyr Pro Leu Phe Ala Lys His Asn20 25 30Met Thr Arg Lys Ile Leu Val Thr Ser Ala Leu Pro Tyr Ala Asn Gly35 40 45Ser Ile His Leu Gly His Met Val Glu His Ile Gln Thr Asp Val Trp50 55 60Val Arg Phe Gln Lys Leu Arg Gly Asn Glu Cys His Tyr Cys Cys Ala65 70 75 80Asp Asp Thr His Gly Thr Pro Val Met Leu Ala Ala Gln Lys Gln Gly85 90 95Ile Ala Pro Glu Asp Met Ile Ala Lys Val Arg Glu Glu His Leu Ala100 105 110Asp Phe Thr Gly Phe Phe Ile Gly Tyr Asp Asn Tyr Tyr Ser Thr His115 120 125Ser Pro Glu Asn Lys Gln Phe Ser Gln Asp Ile Tyr Arg Ala Leu Lys130 135 140Ala Asn Gly Lys Ile Glu Ser Arg Val Ile Glu Gln Leu Phe Asp Pro145 150 155 160Glu Lys Gln Met Phe Leu Pro Asp Arg Phe Val Lys Gly Glu Cys Pro165 170 175Lys Cys His Ala Gln Asp Gln Tyr Gly Asp Asn Cys Glu Val Cys Gly180 185 190Thr Thr Tyr Ser Pro Thr Glu Leu Ile Asn Pro Tyr Ser Ala Val Ser195 200 205
Gly Ala Lys Pro Glu Leu Arg Glu Ser Glu His Phe Phe Phe Lys Leu210 215 220Gly Glu Cys Ala Asp Phe Leu Lys Ala Trp Thr Ser Gly Asn Asn Pro225 230 235 240His Asp Gly Lys Pro His Leu Gln Ala Glu Ala Leu Asn Lys Met245 250 255<210>23<211>1539<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1539)<400>23atg aag ttt tta gac cgt gag gca agc att gcc aag ccg ggt ttc aac48Met Lys Phe Leu Asp Arg Glu Ala Ser Ile Ala Lys Pro Gly Phe Asn1 5 10 15cgt tgg ctc gta ccg ccc gca gca ttg gcg gta cac ctt gcc atc ggg96Arg Trp Leu Val Pro Pro Ala Ala Leu Ala Val His Leu Ala Ile Gly20 25 30cag att tac gcc tat tcc gta ttc aac gcg ccg ctg acc aaa ctt atc144Gln Ile Tyr Ala Tyr Ser Val Phe Asn Ala Pro Leu Thr Lys Leu Ile35 40 45ggc ata acc gaa tcg gcg gcc gga gat tgg aag ctg acg acc gta ggt192Gly Ile Thr Glu Ser Ala Ala Gly Asp Trp Lys Leu Thr Thr Val Gly50 55 60tgg att ttc agt atc gca ctc gcg atg ctg ggc gcg tcg gcc gcc ctg240Trp Ile Phe Ser Ile Ala Leu Ala Met Leu Gly Ala Ser Ala Ala Leu65 70 75 80ttc ggt acg tgg atg gaa cgg gta ggg ccg cgc aaa gcc ata ttt gcc288Phe Gly Thr Trp Met Glu Arg Val Gly Pro Arg Lys Ala Ile Phe Ala85 90 95gcc gcc tgc tgt ttc agc ctg ggc ttc ttc gta tcc gca ttc ggc gtg336Ala Ala Cys Cys Phe Ser Leu Gly Phe Phe Val Ser Ala Phe Gly Val
100 105 110cgt acg cac aac ctc ttc ctg ctc tat ttg ggc aac ggc gtc atc ggc384Arg Thr His Asn Leu Phe Leu Leu Tyr Leu Gly Asn Gly Val Ile Gly115 120 125ggc gta ggc ttg ggt ttg ggc tac atc ggg ccg gtt tcc aca ctg atg432Gly Val Gly Leu Gly Leu Gly Tyr Ile Gly Pro Val Ser Thr Leu Met130 135 140aaa tgg ttt ccc gac aag ccg ggt atg gcg acc ggt ttg gcg att atg480Lys Trp Phe Pro Asp Lys Pro Gly Met Ala Thr Gly Leu Ala Ile Met145 150 155 160ggt ttc ggt ggc ggc gca atg ctg gcc tcg ccg ctt tcc gta tca ctg528Gly Phe Gly Gly Gly Ala Met Leu Ala Ser Pro Leu Ser Val Ser Leu165 170 175atg aac acc ttt tca aac gct act tcg gtt ggg gtt gcc gaa acc ttc576Met Asn Thr Phe Ser Asn Ala Thr Ser Val Gly Val Ala Glu Thr Phe180 185 190gcc gta ttg ggt ctg ctt tac ctc gca ctg atg atg ttc ggc gcg ttt624Ala Val Leu Gly Leu Leu Tyr Leu Ala Leu Met Met Phe Gly Ala Phe195 200 205acc atc cgc gta cct gcc gac ggc tgg aaa cct gaa ggc tat acc gcg672Thr Ile Arg Val Pro Ala Asp Gly Trp Lys Pro Glu Gly Tyr Thr Ala210 215 220ccg aaa acg caa aac aag ctg gtc agc agc aat cat gtc aac gtg tcc720Pro Lys Thr Gln Asn Lys Leu Val Ser Ser Asn His Val Asn Val Ser225 230 235 240caa gcc atg aaa acg ccg cag ttt tgg ctg ttg ttc tgg gta ttg tgc768Gln Ala Met Lys Thr Pro Gln Phe Trp Leu Leu Phe Trp Val Leu Cys245 250 255ctg aac gta act gcc ggc atc ggc gta ttg ggt cag gca tcc gtg atg816Leu Asn Val Thr Ala Gly Ile Gly Val Leu Gly Gln Ala Ser Val Met260 265 270att cag gaa ctc ttt tcc gaa acc tcc ata ggc agg cag gcg gca gtc864Ile Gln Glu Leu Phe Ser Glu Thr Ser Ile Gly Arg Gln Ala Ala Val275 280 285ggc gca ggt gcg gcg gca ggc ttc gtc agc ctc ctg agc ctg ttt aac912Gly Ala Gly Ala Ala Ala Gly Phe Val Ser Leu Leu Ser Leu Phe Asn
290 295 300atg ggc gga cgc ttt ttg tgg tcg agc gtt tcc gac aaa atc gga cgc960Met Gly Gly Arg Phe Leu Trp Ser Ser Val Ser Asp Lys Ile Gly Arg305 310 315 320aaa aac acc tac acc atc ttc ttc gta ctc ggt tcg ctg ctg tat ttc1008Lys Asn Thr Tyr Thr Ile Phe Phe Val Leu Gly Ser Leu Leu Tyr Phe325 330 335gcc gtt ccc tcc atc ggc gag ggc ggc agc aaa gcc ctg ttc atc atc1056Ala Val Pro Ser Ile Gly Glu Gly Gly Ser Lys Ala Leu Phe Ile Ile340 345 350ggc ttt tgc gtg att att tcc atg tac ggc ggc gga ttt gcc gcc att1104Gly Phe Cys Val Ile Ile Ser Met Tyr Gly Gly Gly Phe Ala Ala Ile355 360 365ccc gcc tac ctg aaa gac ctg ttc ggc acc tat cag gtc ggc gcg att1152Pro Ala Tyr Leu Lys Asp Leu Phe Gly Thr Tyr Gln Val Gly Ala Ile370 375 380cac gga cgc atc ctg ctg gcc tgg tca acc gcc gcc gtc atc ggc ccg1200His Gly Arg Ile Leu Leu Ala Trp Ser Thr Ala Ala Val Ile Gly Pro385 390 395 400gta ctg gtc aat tac ata cgc caa agc caa atc gac agc ggc ata ccg1248Val Leu Val Asn Tyr Ile Arg Gln Ser Gln Ile Asp Ser Gly Ile Pro405 410 415gcg gca cag gca tac agc gta acc atg tac atc atg gcg ggt ctg ctg1296Ala Ala Gln Ala Tyr Ser Val Thr Met Tyr Ile Met Ala Gly Leu Leu420 425 430att atc ggt ttg ttg tgc aac ctc gcc gtc aaa tcc gta cac gaa aaa1344Ile Ile Gly Leu Leu Cys Asn Leu Ala Val Lys Ser Val His Glu Lys435 440 445cac cac gaa aaa gac atc aaa acc gcc gca cac agc ggc aac ccc gat1392His His Glu Lys Asp Ile Lys Thr Ala Ala His Ser Gly Asn Pro Asp450 455 460gac gaa acc gcc ata tcc gac gct tac ctt gtg ggc gaa aaa gtt tcc1440Asp Glu Thr Ala Ile Ser Asp Ala Tyr Leu Val Gly Glu Lys Val Ser465 470 475 480ggc ggc ggc ata tcg gtc tgg tgg cgt tgg gca ttg gcc gtc ata ccg1488Gly Gly Gly Ile Ser Val Trp Trp Arg Trp Ala Leu Ala Val Ile Pro
485 490 495ctc gcc tac ggc gtg gtg atg atc ttt gtc aaa gca ctc gac ctt ttc1536Leu Ala Tyr Gly Val Val Met Ile Phe Val Lys Ala Leu Asp Leu Phe500 505 510tcc1539Ser<210>24<211>513<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>24Met Lys Phe Leu Asp Arg Glu Ala Ser Ile Ala Lys Pro Gly Phe Ash1 5 10 15Arg Trp Leu Val Pro Pro Ala Ala Leu Ala Val His Leu Ala Ile Gly20 25 30Gln Ile Tyr Ala Tyr Ser Val Phe Asn Ala Pro Leu Thr Lys Leu Ile35 40 45Gly Ile Thr Glu Ser Ala Ala Gly Asp Trp Lys Leu Thr Thr Val Gly50 55 60Trp Ile Phe Ser Ile Ala Leu Ala Met Leu Gly Ala Ser Ala Ala Leu65 70 75 80Phe Gly Thr Trp Met Glu Arg Val Gly Pro Arg Lys Ala Ile Phe Ala85 90 95Ala Ala Cys Cys Phe Ser Leu Gly Phe Phe Val Ser Ala Phe Gly Val100 105 110Arg Thr His Asn Leu Phe Leu Leu Tyr Leu Gly Asn Gly Val Ile Gly115 120 125Gly Val Gly Leu Gly Leu Gly Tyr Ile Gly Pro Val Ser Thr Leu Met130 135 140Lys Trp Phe Pro Asp Lys Pro Gly Met Ala Thr Gly Leu Ala Ile Met145 150 155 160Gly Phe Gly Gly Gly Ala Met Leu Ala Ser Pro Leu Ser Val Ser Leu165 170 175
Met Asn Thr Phe Ser Asn Ala Thr Ser Val Gly Val Ala Glu Thr Phe180 185 190Ala Val Leu Gly Leu Leu Tyr Leu Ala Leu Met Met Phe Gly Ala Phe195 200 205Thr Ile Arg Val Pro Ala Asp Gly Trp Lys Pro Glu Gly Tyr Thr Ala210 215 220Pro Lys Thr Gln Asn Lys Leu Val Ser Ser Asn His Val Asn Val Ser225 230 235 240Gln Ala Met Lys Thr Pro Gln Phe Trp Leu Leu Phe Trp Val Leu Cys245 250 255Leu Asn Val Thr Ala Gly Ile Gly Val Leu Gly Gln Ala Ser Val Met260 265 270Ile Gln Glu Leu Phe Ser Glu Thr Ser Ile Gly Arg Gln Ala Ala Val275 280 285Gly Ala Gly Ala Ala Ala Gly Phe Val Ser Leu Leu Ser Leu Phe Asn290 295 300Met Gly Gly Arg Phe Leu Trp Ser Ser Val Ser Asp Lys Ile Gly Arg305 310 315 320Lys Asn Thr Tyr Thr Ile Phe Phe Val Leu Gly Ser Leu Leu Tyr Phe325 330 335Ala Val Pro Ser Ile Gly Glu Gly Gly Ser Lys Ala Leu Phe Ile Ile340 345 350Gly Phe Cys Val Ile Ile Ser Met Tyr Gly Gly Gly Phe Ala Ala Ile355 360 365Pro Ala Tyr Leu Lys Asp Leu Phe Gly Thr Tyr Gln Val Gly Ala Ile370 375 380His Gly Arg Ile Leu Leu Ala Trp Ser Thr Ala Ala Val Ile Gly Pro385 390 395 400Val Leu Val Asn Tyr Ile Arg Gln Ser Gln Ile Asp Ser Gly Ile Pro405 410 415Ala Ala Gln Ala Tyr Ser Val Thr Met Tyr Ile Met Ala Gly Leu Leu420 425 430
Ile Ile Gly Leu Leu Cys Asn Leu Ala Val Lys Ser Val His Glu Lys435 440 445His His Glu Lys Asp Ile Lys Thr Ala Ala His Ser Gly Asn Pro Asp450 455 460Asp Glu Thr Ala Ile Ser Asp Ala Tyr Leu Val Gly Glu Lys Val Ser465 470 475 480Gly Gly Gly Ile Ser Val Trp Trp Arg Trp Ala Leu Ala Val Ile Pro485 490 495Leu Ala Tyr Gly Val Val Met Ile Phe Val Lys Ala Leu Asp Leu Phe500 505 510Ser<210>25<211>1038<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1038)<400>25ttg cag cct tta gtc agc gta ttg att tgc gcc tac aac gta gaa aaa48Leu Gln Pro Leu Val Ser Val Leu Ile Cys Ala Tyr Asn Val Glu Lys1 5 10 15tat ttc gcc caa tca tta gcc acc gtc gtg aat cag act tgg cgc aac96Tyr Phe Ala Gln Ser Leu Ala Thr Val Val Asn Gln Thr Trp Arg Asn20 25 30ttg gag att ttg att gtc gat gac ggc tcg aca gac ggt acg ctt gcc144Leu Glu Ile Leu Ile Val Asp Asp Gly Ser Thr Asp Gly Thr Leu Ala35 40 45att gcc aag gat ttt caa aag cgg gac agc cgt atc aaa atc ctt gca192Ile Ala Lys Asp Phe Gln Lys Arg Asp Ser Arg Ile Lys Ile Leu Ala50 55 60caa gct caa aat tcc ggc ctg att ccc tct tta aac atc ggg ctg gac240
Gln Ala Gln Asn Ser Gly Leu Ile Pro Ser Leu Asn Ile Gly Leu Asp65 70 75 80gaa ttg gca aag tca gga atg ggg gaa tat att gca cgc acc gat gcc288Glu Leu Ala Lys Ser Gly Met Gly Glu Tyr Ile Ala Arg Thr Asp Ala85 90 95gac gat att gcc gcc ccc gac tgg att gag aaa atc gtg ggc gag atg336Asp Asp Ile Ala Ala Pro Asp Trp Ile Glu Lys Ile Val Gly Glu Met100 105 110gaa aaa gac cgc agc atc atc gcg atg ggc gcg tgg ctg gaa gtt ttg384Glu Lys Asp Arg Ser Ile Ile Ala Met Gly Ala Trp Leu Glu Val Leu115 120 125tcg gaa gaa aag gac ggc aac cgg ctg gcg cgg cat cac agg cac ggc432Ser Glu Glu Lys Asp Gly Asn Arg Leu Ala Arg His His Arg His Gly130 135 140aaa att tgg aaa aag ccg acc cgg cac gaa gat att gcc gac ttt ttc480Lys Ile Trp Lys Lys Pro Thr Arg His Glu Asp Ile Ala Asp Phe Phe145 150 155 160cct ttc ggc aac ccc ata cac aac aac acg atg att atg cgg cgc agc528Pro Phe Gly Asn Pro Ile His Asn Asn Thr Met Ile Met Arg Arg Ser165 170 175gtc att gac ggc gga ttg cgt tac aac acc gag cgg gat tgg gcg gaa576Val Ile Asp Gly Gly Leu Arg Tyr Asn Thr Glu Arg Asp Trp Ala Glu180 185 190gat tac caa ttt tgg tac gat gtc agc aaa ttg ggc agg ctg gct tat624Asp Tyr Gln Phe Trp Tyr Asp Val Ser Lys Leu Gly Arg Leu Ala Tyr195 200 205tat ccc gaa gcc ttg gtc aaa tac cgc ctt cac gcc aat cag gtt tca672Tyr Pro Glu Ala Leu Val Lys Tyr Arg Leu His Ala Asn Gln Val Ser210 215 220tcc aaa tac agc atc cgc caa cac gaa atc gcg caa ggc atc caa aaa720Ser Lys Tyr Ser Ile Arg Gln His Glu Ile Ala Gln Gly Ile Gln Lys225 230 235 240acc gcc aga aac gat ttt ttg cag tct atg ggt ttt aaa acc cgg ttc768Thr Ala Arg Asn Asp Phe Leu Gln Ser Met Gly Phe Lys Thr Arg Phe245 250 255gac agc ctt gaa tac cgc caa ata aaa gca gta gcg tat gaa ttg ctg816
Asp Ser Leu Glu Tyr Arg Gln Ile Lys Ala Val Ala Tyr Glu Leu Leu260 265 270gag aaa cat ttg ccg gaa gaa gat ttt gaa cgc gcc cgc cgg ttt ttg864Glu Lys His Leu Pro Glu Glu Asp Phe Glu Arg Ala Arg Arg Phe Leu275 280 285tac caa tgc ttc aaa cgg acg gac acg ccg ccc gcc ggc gcg tgg ctg912Tyr Gln cys Phe Lys Arg Thr Asp Thr Pro Pro Ala Gly Ala Trp Leu290 295 300gat ttc gcg gca gac ggc aag atg agg cgg ctg ttt acc atg agg caa960Asp Phe Ala Ala Asp Gly Lys Met Arg Arg Leu Phe Thr Met Arg Gln305 310 315 320tac ttc ggc att ttg cac cgg ctg att aaa aac cgc cgg cag gcg cgg1008Tyr Phe Gly Ile Leu His Arg Leu Ile Lys Asn Arg Arg Gln Ala Arg325 330 335tcg gat tcg gca ggg aaa gaa cag gag att1038Ser Asp Ser Ala Gly Lys Glu Gln Glu Ile340 345<210>26<211>346<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>26Leu Gln Pro Leu Val Ser Val Leu Ile Cys Ala Tyr Asn Val Glu Lys1 5 10 15Tyr Phe Ala Gln Ser Leu Ala Thr Val Val Asn Gln Thr Trp Arg Asn20 25 30Leu Glu Ile Leu Ile Val Asp Asp Gly Ser Thr Asp Gly Thr Leu Ala35 40 45Ile Ala Lys Asp Phe Gln Lys Arg Asp Ser Arg Ile Lys Ile Leu Ala50 55 60Gln Ala Gln Asn Ser Gly Leu Ile Pro Ser Leu Asn Ile Gly Leu Asp65 70 75 80Glu Leu Ala Lys Ser Gly Met Gly Glu Tyr Ile Ala Arg Thr Asp Ala85 90 95
Asp Asp Ile Ala Ala Pro Asp Trp Ile Glu Lys Ile Val Gly Glu Met100 105 110Glu Lys Asp Arg Ser Ile Ile Ala Met Gly Ala Trp Leu Glu Val Leu115 120 125Ser Glu Glu Lys Asp Gly Asn Arg Leu Ala Arg His His Arg His Gly130 135 140Lys Ile Trp Lys Lys Pro Thr Arg His Glu Asp Ile Ala Asp Phe Phe145 150 155 160Pro Phe Gly Asn Pro Ile His Asn Asn Thr Met Ile Met Arg Arg Ser165 170 175Val Ile Asp Gly Gly Leu Arg Tyr Asn Thr Glu Arg Asp Trp Ala Glu180 185 190Asp Tyr Gln Phe Trp Tyr Asp Val Ser Lys Leu Gly Arg Leu Ala Tyr195 200 205Tyr Pro Glu Ala Leu Val Lys Tyr Arg Leu His Ala Asn Gln Val Ser210 215 220Ser Lys Tyr Ser Ile Arg Gln His Glu Ile Ala Gln Gly Ile Gln Lys225 230 235 240Thr Ala Arg Asn Asp Phe Leu Gln Ser Met Gly Phe Lys Thr Arg Phe245 250 255Asp Ser Leu Glu Tyr Arg Gln Ile Lys Ala Val Ala Tyr Glu Leu Leu260 265 270Glu Lys His Leu Pro Glu Glu Asp Phe Glu Arg Ala Arg Arg Phe Leu275 280 285Tyr Gln Cys Phe Lys Arg Thr Asp Thr Pro Pro Ala Gly Ala Trp Leu290 295 300Asp Phe Ala Ala Asp Gly Lys Met Arg Arg Leu Phe Thr Met Arg Gln305 310 315 320Tyr Phe Gly Ile Leu His Arg Leu Ile Lys Asn Arg Arg Gln Ala Arg325 330 335Ser Asp Ser Ala Gly Lys Glu Gln Glu Ile340 345
<210>27<211>1856<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1857)<400>27atg cca gaa tac cgc tcc aaa acc tcc acc cac ggt cgc aat atg gcg48Met Pro Glu Tyr Arg Ser Lys Thr Ser Thr His Gly Arg Asn Met Ala1 5 10 15ggc gcg cgc gcg ttg tgg cgc gcc acc ggc gtg atg gaa acc gac ttc96Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Val Met Glu Thr Asp Phe20 25 30ggc aaa ccg att atc gcc gtt gcc aac tcg ttc acc caa ttc gtg cca144Gly Lys Pro Ile Ile Ala Val Ala Asn Ser Phe Thr Gln Phe Val Pro35 40 45ggt cat gtc cac ctg cac aat atg ggc cag ctg gtt gcc cgc gaa atc192Gly His Val His Leu His Asn Met Gly Gln Leu Val Ala Arg Glu Ile50 55 60gaa aaa gcc ggc gcc atc gcc aaa gaa ttc aac acc atc gcc atc gac240Glu Lys Ala Gly Ala Ile Ala Lys Glu Phe Asn Thr Ile Ala Ile Asp65 70 75 80gac ggc atc gct atg gga cac agc ggt atg ctg tat tcc ctg ccc agc288Asp Gly Ile Ala Met Gly His Ser Gly Met Leu Tyr Ser Leu Pro Ser85 90 95cgc gat ttg att gcc gac tcc atc gaa tat atg gtc aat gcc cac tgc336Arg Asp Leu Ile Ala Asp Ser Ile Glu Tyr Met Val Asn Ala His Cys100 105 110gcc gac gcg ctg gtg tgc att tcc aac tgc gac aaa atc acc ccg ggc384Ala Asp Ala Leu Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly115 120 125atg ctg att gcc gcg atg cgc ctg aac atc ccg acc atc ttc gtt tcc432Met Leu Ile Ala Ala Met Arg Leu Asn Ile Pro Thr Ile Phe Val Ser130 135 140
ggc ggt ccg atg gaa gca ggt aaa gtt atc ggc gtg gca aac atc cag480Gly Gly Pro Met Glu Ala Gly Lys Val Ile Gly Val Ala Asn Ile Gln145 150 155 160ccc gaa cgc cgt ttg gac ttg att gac gcg atg att gaa tcg gcg gac528Pro Glu Arg Arg Leu Asp Leu Ile Asp Ala Met Ile Glu Ser Ala Asp165 170 175gac aat atc agc aac cgg caa gtt gaa gaa gtc gaa caa aac gcc tgc576Asp Asn Ile Ser Asn Arg Gln Val Glu Glu Val Glu Gln Asn Ala Cys180 185 190ccg acc tgc ggc tcg tgt tcg ggt atg ttt acg gca aac tcg atg aac624Pro Thr Cys Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn195 200 205tgc ctg acc gaa gca ctc ggg ctg tcc ctg ccg ggc aac ggt tct tac672Cys Leu Thr Glu Ala Leu Gly Leu Ser Leu Pro Gly Asn Gly Ser Tyr210 215 220ctc gcc acc cac gtc ggc cgc aaa gaa ctg ttc ctc gaa gcc ggc cgt720Leu Ala Thr His Val Gly Arg Lys Glu Leu Phe Leu Glu Ala Gly Arg225 230 235 240atg att gtc gaa atc acc aaa cgc tat tac gag caa aac gat gaa acc768Met Ile Val Glu Ile Thr Lys Arg Tyr Tyr Glu Gln Asn Asp Glu Thr245 250 255gtg tta ccg cgc agc att gcc acc aaa aaa gcg ttt gaa aac gct atg816Val Leu Pro Arg Ser Ile Ala Thr Lys Lys Ala Phe Glu Asn Ala Met260 265 270acc atg gac att gcc atg ggc ggc agc acc aac act att ttg cat tta864Thr Met Asp Ile Ala Met Gly Gly Ser Thr Asn Thr Ile Leu His Leu275 280 285ctc gcc gtt gcc aac gaa gcg ggc gtg gat ttc aaa atg gca gac atc912Leu Ala Val Ala Asn Glu Ala Gly Val Asp Phe Lys Met Ala Asp Ile290 295 300gac cgc tta agc cgc gtt gtg ccc tgc atc tgc aaa acc gca ccc aac960Asp Arg Lau Ser Arg Val Val Pro Cys Ile Cys Lys Thr Ala Pro Asn305 310 315 320aac cac gac tac tat atg gaa gac gtg cac cga gcc ggc ggc atc ttc1008Asn His Asp Tyr Tyr Met Glu Asp Val His Arg Ala Gly Gly Ile Phe325 330 335
gcc atc ctg aaa gaa ttg gac aaa gcg ggc aag ctg cac acc gac gtg1056Ala Ile Leu Lys Glu Leu Asp Lys Ala Gly Lys Leu His Thr Asp Val340 345 350cac act atc cac gcg ccg acg ctg aaa gac gcg att gaa aaa tgg gac1104His Thr Ile His Ala Pro Thr Leu Lys Asp Ala Ile Glu Lys Trp Asp355 360 365gta acc aac cct gaa aac acc cac gcc atc gaa cgc ttc aaa gcc gcg1152Val Thr Asn Pro Glu Asn Thr His Ala Ile Glu Arg Phe Lys Ala Ala370 375 380ccc ggc ggc gta cgc acc acc caa gcg ttc tcg caa aac cgt atg tgg1200Pro Gly Gly Val Arg Thr Thr Gln Ala Phe Ser Gln Asn Arg Met Trp385 390 395 400aaa acc ctc gac ctc gac cgc gaa aaa ggc tgt atc cgc gac gtg gca1248Lys Thr Leu Asp Leu Asp Arg Glu Lys Gly Cys Ile Arg Asp Val Ala405 410 415cac gcc tac tcg caa gac ggc ggt ttg gcg gtc ttg ttc ggc aac atc1296His Ala Tyr Ser Gln Asp Gly Gly Leu Ala Val Leu Phe Gly Asn Ile420 425 430gcc gag cgc ggc tgc gtg gta aaa acc gca ggc gtg gac gag agc atc1344Ala Glu Arg Gly Cys Val Val Lys Thr Ala Gly Val Asp Glu Ser Ile435 440 445ctc aaa ttc acc ggc cgc gcc cgc gtg ttt gaa agc caa gaa gac gca1392Leu Lys Phe Thr Gly Arg Ala Arg Val Phe Glu Ser Gln Glu Asp Ala450 455 460gta gaa ggc att ttg ggc aac caa atc gtc gcc ggc gac atc gtc atc1440Val Glu Gly Ile Leu Gly Asn Gln Ile Val Ala Gly Asp Ile Val Ile465 470 475 480atc cgc tac gaa ggc ccg aaa ggc ggc ccg ggc atg cag gaa atg ctg1488Ile Arg Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu485 490 495tat ccg act tcc tac ctg aaa tct aaa ggc ctc ggc aaa gcc tgc gct1536Tyr Pro Thr Ser Tyr Leu Lys Ser Lys Gly Leu Gly Lys Ala Cys Ala500 505 510ctc tta acc gac gga cgc ttc tcc ggc ggc aca tca ggt ttg tcc atc1584Leu Leu Thr Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile515 520 525
gga cac gcc tcg ccc gaa gcg gcg gaa ggt ggc gcg atc ggt ttg gta1632Gly His Ala Ser Pro Glu Ala Ala Glu Gly Gly Ala Ile Gly Leu Val530 535 540cac gaa ggc gat acc gtc gaa atc gac atc ccc aac cgc agc atc cgc1680His Glu Gly Asp Thr Val Glu Ile Asp Ile Pro Asn Arg Ser Ile Arg545 550 555 560ctt gtc att tcc gac gaa gaa ctc gcc gcc cgc cgt gcc gaa atg gaa1728Leu Val Ile Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Glu Met Glu565 570 575gca cgc ggc agc aaa gcg tgg aaa ccg gaa aac cgc gac cgc tac gtc1776Ala Arg Gly Ser Lys Ala Trp Lys Pro Glu Asn Arg Asp Arg Tyr Val580 585 590tcc gcc gca tta aga gct tac ggc gcg atg gcg act tcc gcc gac aaa1824Ser Ala Ala Leu Arg Ala Tyr Gly Ala Met Ala Thr Ser Ala Asp Lys595 600 605ggc gcg gtg cgc gac gta gcg caa atc gaa aga1857Gly Ala Val Arg Asp Val Ala Gln Ile Glu Arg610 615<210>28<211>619<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>28Met Pro Glu Tyr Arg Ser Lys Thr Ser Thr His Gly Arg Asn Met Ala1 5 10 15Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Val Met Glu Thr Asp Phe20 25 30Gly Lys Pro Ile Ile Ala Val Ala Asn Ser Phe Thr Gln Phe Val Pro35 40 45Gly His Val His Leu His Asn Met Gly Gln Leu Val Ala Arg Glu Ile50 55 60Glu Lys Ala Gly Ala Ile Ala Lys Glu Phe Asn Thr Ile Ala Ile Asp65 70 75 80Asp Gly Ile Ala Met Gly His Ser Gly Met Leu Tyr Ser Leu Pro Ser85 90 95
Arg Asp Leu Ile Ala Asp Ser Ile Glu Tyr Met Val Asn Ala His Cys100 105 110Ala Asp Ala Leu Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly115 120 125Met Leu Ile Ala Ala Met Arg Leu Asn Ile Pro Thr Ile Phe Val Ser130 135 140Gly Gly Pro Met Glu Ala Gly Lys Val Ile Gly Val Ala Asn Ile Gln145 150 155 160Pro Glu Arg Arg Leu Asp Leu Ile Asp Ala Met Ile Glu Ser Ala Asp165 170 175Asp Asn Ile Ser Asn Arg Gln Val Glu Glu Val Glu Gln Asn Ala Cys180 185 190Pro Thr Cys Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn195 200 205Cys Leu Thr Glu Ala Leu Gly Leu Ser Leu Pro Gly Asn Gly Ser Tyr210 215 220Leu Ala Thr His Val Gly Arg Lys Glu Leu Phe Leu Glu Ala Gly Arg225 230 235 240Met Ile Val Glu Ile Thr Lys Arg Tyr Tyr Glu Gln Asn Asp Glu Thr245 250 255Val Leu Pro Arg Ser Ile Ala Thr Lys Lys Ala Phe Glu Asn Ala Met260 265 270Thr Met Asp Ile Ala Met Gly Gly Ser Thr Asn Thr Ile Leu His Leu275 280 285Leu Ala Val Ala Asn Glu Ala Gly Val Asp Phe Lys Met Ala Asp Ile290 295 300Asp Arg Leu Ser Arg Val Val Pro Cys Ile Cys Lys Thr Ala Pro Asn305 310 315 320Asn His Asp Tyr Tyr Met Glu Asp Val His Arg Ala Gly Gly Ile Phe325 330 335Ala Ile Leu Lys Glu Leu Asp Lys Ala Gly Lys Lau His Thr Asp Val340 345 350
His Thr Ile His Ala Pro Thr Leu Lys Asp Ala Ile Glu Lys Trp Asp355 360 365Val Thr Asn Pro Glu Asn Thr His Ala Ile Glu Arg Phe Lys Ala Ala370 375 380Pro Gly Gly Val Arg Thr Thr Gln Ala Phe Ser Gln Asn Arg Met Trp385 390 395 400Lys Thr Leu Asp Leu Asp Arg Glu Lys Gly Cys Ile Arg Asp Val Ala405 410 415His Ala Tyr Ser Gln Asp Gly Gly Leu Ala Val Leu Phe Gly Asn Ile420 425 430Ala Glu Arg Gly Cys Val Val Lys Thr Ala Gly Val Asp Glu Ser Ile435 440 445Leu Lys Phe Thr Gly Arg Ala Arg Val Phe Glu Ser Gln Glu Asp Ala450 455 460Val Glu Gly Ile Leu Gly Asn Gln Ile Val Ala Gly Asp Ile Val Ile465 470 475 480Ile Arg Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu485 490 495Tyr Pro Thr Ser Tyr Leu Lys Ser Lys Gly Leu Gly Lys Ala Cys Ala500 505 510Leu Leu Thr Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile515 520 525Gly His Ala Ser Pro Glu Ala Ala Glu Gly Gly Ala Ile Gly Leu Val530 535 540His Glu Gly Asp Thr Val Glu Ile Asp Ile Pro Asn Arg Ser Ile Arg545 550 555 560Leu Val Ile Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Glu Met Glu565 570 575Ala Arg Gly Ser Lys Ala Trp Lys Pro Glu Asn Arg Asp Arg Tyr Val580 585 590Ser Ala Ala Leu Arg Ala Tyr Gly Ala Met Ala Thr Ser Ala Asp Lys595 600 605
Gly Ala Val Arg Asp Val Ala Gln Ile Glu Arg610 615<210>29<211>1725<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1725)<400>29atg cag cta tca ggc gcg caa atc ata gtg cag agt ctc aaa gcc gaa48Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu1 5 10 15ggt gtc gag tac gtt ttc ggt tat ccc ggc ggt gcg gtt atc gaa atc96Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile20 25 30tac gat gcc ctt ttc caa ctc aat aaa ttc aag cac att ctg acc cgt144Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile LeH Thr Arg35 40 45cac gag cag gcg gca gta cac gcg gca gat gcg tat gcg cgc gtc agc192His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser50 55 60ggt aag gtg ggc gtg gca ttg gtt aca tcc ggc ccg ggc gtt acc aat240Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn65 70 75 80gca ctg acc ggt att gct act gcc tat acg gat tcg att ccg atg gtg288Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val85 90 95gtc atc agc ggg cag gta ggc aat tcc ctg att ggt acg gat gcg ttc336Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe100 105 110caa gaa gtt gat acg gtg ggt att acc cgt ccg tgc gtc aaa cac aat384Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn115 120 125
ttc ctg gtt acg gac atc aat gag ttg gcg gaa acc att aaa aag gcg432Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala130 135 140ttc caa att gcc gca agc ggc cga ccg ggg ccc gtg gtg gtt gat gtc480Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val145 150 155 160ccg aaa gat gtt acg cag gcg atg gcg aaa ttc agc tat cct cag gaa528Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu165 170 175gac att ttt atc cgt tcg tat caa ccg gtt gtt caa ggg cat atc ggt576Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly180 185 190cag att aaa aag gcc gtg cag atg ttg gca tct gcc aaa cgt ccg gtc624Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val195 200 205gtc tat ttt ggc ggc ggc gtg gtg ttg ggt aat gct tct gaa gag ctg672Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu210 215 220acc cga ttt gtc cga atg acg ggt gct ccg tgc acg ggt acg ctg atg720Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met225 230 235 240ggc ttg ggc gct tat cct tcc ggc gac cgc caa ttc ctc ggt atg ctc768Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu245 250 255ggt atg cac ggt act tac gag gca aac ctt gcc atg cag aat gcg gat816Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp260 265 270gtc gtt ctt gcc gta ggt gcg cgt ttt gac gac cgt gtg gtt tcc gta864Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val275 280 285ccg tcc aaa ttt ttc gag aag gcg aag aag gtt atc cat atc gat gtc912Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val290 295 300gat cct tcc agc atc gcc aaa cgc gtg aag gcg gac att ccg att gtc960Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val305 310 315 320
ggc gac gtg aaa aac gtt ttg tcc gag atg gtt gcg ctg tgg caa aaa1008Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys325 330 335caa gag tcc gtg ccg tct gaa gat gct ttg ggc aaa tgg tgg aaa acc1056Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr340 345 350ata gag gaa tgg cgt tcc cgc gat tgc ttg tgg ttt gac aac ggc agc1104Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser355 360 365gaa att atc aag cca caa tat gtg att cag aag ctt gcc gag att acc1152Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr370 375 380ggc aat tcg gca atc atc aca tcg gat gta ggg cag cat caa atg ttt1200Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe385 390 395 400gcg gct caa tat tat ccc ttc gaa cgt ccg cgc caa tgg ctc aac tcc1248Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser405 410 415ggc ggt ttg ggt acg atg ggc gtt ggt ctg cct tat gcg att ggt gca1296Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala420 425 430aaa ctt gcc gcc ccg gat caa gac gta ttc tgt att acc ggc gac ggc1344Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly435 440 445tcg atc cag atg aac atc caa gag ctg tcc acc tgt ttc caa tat cgg1392Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg450 455 460att ccg gtt aac gtc att acg ctg aac aac ggt tat ctc ggt atg gta1440Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val465 470 475 480cgc cag tgg cag gaa ata tat tac ggc gga cga gag tcg gaa acc tat1488Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr485 490 495ttc gat tct ttg ccc gat ttc gtc aaa ctt gcc gag gca tac ggc cat1536Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His500 505 510
atc ggt atc cgc gtg gac aag aag tct gat gtg gaa ggt gcg ttg ttg1584Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu515 520 525gaa gca ttg aac caa aaa gac agg ctg gtg ttt atc gac ttc ctg acc1632Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr530 535 540gac cag aaa cag aat gtg atg ccc atg gtc ggc aac ggc aaa ggt ttg1680Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu545 550 555 560gac gaa atg gta ctt ccg ccg cat atg cgt gcg gac gga aag gcg1725Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala565 570 575<210>30<211>575<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>30Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu1 5 10 15Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile20 25 30Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile Leu Thr Arg35 40 45His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser50 55 60Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn65 70 75 80Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val85 90 95Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe100 105 110Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn115 120 125Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala
130 135 140Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val145 150 155 160Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu165 170 175Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly180 185 190Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val195 200 205Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu210 215 220Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met225 230 235 240Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu245 250 255Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp260 265 270Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val275 280 285Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val290 295 300Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val305 310 315 320Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys325 330 335Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr340 345 350Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser355 360 365Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr370 375 380Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe
385 390 395 400Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser405 410 415Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala420 425 430Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly435 440 445Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg450 455 460Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val465 470 475 480Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr485 490 495Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His500 505 510Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu515 520 525Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr530 535 540Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu545 550 555 560Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala565 570 575<210>31<211>651<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(651)<400>31atg ttt tcc gta ccg cgt tcc ttt ttg ccg ggc gtt ttc gta ctt gcc48
Met Phe Ser Val Pro Arg Ser Phe Leu Pro Gly Val Phe Val Leu Ala1 5 10 15gcg ctt gcc gcc tgc aaa cct caa gac aac agt gcg gcg caa gtc gct96Ala Leu Ala Ala Cys Lys Pro Gln Asp Asn Ser Ala Ala Gln Val Ala20 25 30tct tca agt gca tcc gcg tcg gct gcg gaa aat gcg gca aag ccg caa144Ser Ser Ser Ala Ser Ala Ser Ala Ala Glu Asn Ala Ala Lys Pro Gln35 40 45acg cgc ggt acg gat atg cgt aag gaa gac atc ggc ggc gat ttc acg192Thr Arg Gly Thr Asp Met Arg Lys Glu Asp Ile Gly Gly Asp Phe Thr50 55 60ctg acc gac ggc gaa ggc aag cct ttc aac ctg agc gat ttg aaa ggc240Leu Thr Asp Gly Glu Gly Lys Pro Phe Asn Leu Ser Asp Leu Lys Gly65 70 75 80aag gtc gtg att ctg tct ttc ggc ttt acg cac tgt ccc gat gtc tgc288Lys Val Val Ile Leu Ser Phe Gly Phe Thr His Cys Pro Asp Val Cys85 90 95ccg aca gag ctt ttg acg tac agc gac acg ttg aag cag ttg ggc ggg336Pro Thr Glu Leu Leu Thr Tyr Ser Asp Thr Leu Lys Gln Leu Gly Gly100 105 110cag gct aag gac gtg aaa gtg gtg ttc gtc agc atc gat ccg gaa cgc384Gln Ala Lys Asp Val Lys Val Val Phe Val Ser Ile Asp Pro Glu Arg115 120 125gac acg cct gaa atc atc ggc aag tat gcc aaa cag ttc aat ccg gac432Asp Thr Pro Glu Ile Ile Gly Lys Tyr Ala Lys Gln Phe Asn Pro Asp130 135 140ttt atc ggt ctg acg gca acg ggc gac caa aac ctg ccg gtc atc aag480Phe Ile Gly Leu Thr Ala Thr Gly Asp Gln Asn Leu Pro Val Ile Lys145 150 155 160cag caa tac cgc gtg gtt tct gcc aaa gtc aat caa aaa gac gac agc528Gln Gln Tyr Arg Val Val Ser Ala Lys Val Asn Gln Lys Asp Asp Ser165 170 175gaa aac tat ttg gtc gac cac tct tcc ggt gcg tat ctc atc gac aaa576Glu Asn Tyr Leu Val Asp His Ser Ser Gly Ala Tyr Leu Ile Asp Lys180 185 190aac ggt gag gtt gcc att ttc tcg cct tac gga agc gag ccg gaa acg624
Asn Gly Glu Val Ala Ile Phe Ser Pro Tyr Gly Ser Glu Pro Glu Thr195 200 205att gct gcc gat gta agg acc ctg ctc 651Ile Ala Ala Asp Val Arg Thr Leu Leu210 215<210>32<211>217<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>32Met Phe Ser Val Pro Arg Ser Phe Leu Pro Gly Val Phe Val Leu Ala1 5 10 15Ala Leu Ala Ala Cys Lys Pro Gln Asp Asn Ser Ala Ala Gln Val Ala20 25 30Ser Ser Ser Ala Ser Ala Ser Ala Ala Glu Asn Ala Ala Lys Pro Gln35 40 45Thr Arg Gly Thr Asp Met Arg Lys Glu Asp Ile Gly Gly Asp Phe Thr50 55 60Leu Thr Asp Gly Glu Gly Lys Pro Phe Asn Leu Ser Asp Leu Lys Gly65 70 75 80Lys Val Val Ile Leu Ser Phe Gly Phe Thr His Cys Pro Asp Val Cys85 90 95Pro Thr Glu Leu Leu Thr Tyr Ser Asp Thr Leu Lys Gln Leu Gly Gly100 105 110Gln Ala Lys Asp Val Lys Val Val Phe Val Ser Ile Asp Pro Glu Arg115 120 125Asp Thr Pro Glu Ile Ile Gly Lys Tyr Ala Lys Gln Phe Asn Pro Asp130 135 140Phe Ile Gly Leu Thr Ala Thr Gly Asp Gln Asn Leu Pro Val Ile Lys145 150 155 160Gln Gln Tyr Arg Val Val Ser Ala Lys Val Asn Gln Lys Asp Asp Ser165 170 175Glu Asn Tyr Leu Val Asp His Ser Ser Gly Ala Tyr Leu Ile Asp Lys
180 185 190Asn Gly Glu Val Ala Ile Phe Ser Pro Tyr Gly Ser Glu Pro Glu Thr195 200 205Ile Ala Ala Asp Val Arg Thr Leu Leu210 215<210>33<211>330<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(330)<400>33ttg ccg ctg ctt tgt tgt ctt tgg ttt tgg cag cct gcg gcg gtg aaa48Leu Pro Leu Leu Cys Cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys1 5 10 15aag ccg ctg aag ctc ccg ctg ctg aag cac ctg ccg ccg aag ctc ccg96Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro20 25 30cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg aag cac ctg ccg144Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro35 40 45ccg aag ctc ctg cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg192Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu50 55 60aag ctg ccg cta ccg aag cac ctg ccg ctg aag ctg ccg cta ccg aag240Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys65 70 75 80cac ctg ccg ctg aag ctc ctg ctg ccg aag ctg caa aat aag cat ttt288His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe85 90 95ccg ctt gca aaa aag cag gat acg ttc agt atc ctg ctt ttt330Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe100 105 110
<210>34<211>110<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>34Leu Pro Leu Leu Cys Cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys1 5 10 15Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro20 25 30Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro35 40 45Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu50 55 60Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys65 70 75 80His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe85 90 95Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe100 105 110<210>35<211>2118<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(2118)<400>35atg ttc gac aaa cac gtt aag acc ttc caa tac ggt aat cag acc gtt48Met Phe Asp Lys His Val Lys Thr Phe Gln Tyr Gly Asn Gln Thr Val1 5 10 15act ttg gaa acc ggc gaa att gcc cgc caa gcc gcc gct gcc gtt aaa96Thr Leu Glu Thr Gly Glu Ile Ala Arg Gln Ala Ala Ala Ala Val Lys20 25 30
gtc tct atg ggc gac acc gtg gtt ttg gtt gcc gtt acc acc aac aaa144Val Ser Met Gly Asp Thr Val Val Leu Val Ala Val Thr Thr Asn Lys35 40 45gaa gtg aaa gaa ggc caa gac ttc ttc ccc ctg acc gtc gat tat ttg192Glu Val Lys Glu Gly Gln Asp Phe Phe Pro Leu Thr Val Asp Tyr Leu50 55 60gaa cgc act tac gcc gca ggt aaa atc ccc ggc ggt ttc ttc aaa cgc240Glu Arg Thr Tyr Ala Ala Gly Lys Ile Pro Gly Gly Phe Phe Lys Arg65 70 75 80gaa ggc aaa caa agc gaa aaa gaa atc ctg acc agc cgt ctg atc gac288Glu Gly Lys Gln Ser Glu Lys Glu Ile Leu Thr Ser Arg Leu Ile Asp85 90 95cgc ccg att cgt ccg ctg ttc ccc gaa ggt ttc tac cac gac atc caa336Arg Pro Ile Arg Pro Leu Phe Pro Glu Gly Phe Tyr His Asp Ile Gln100 105 110atc gta gcg atg gtc gtg tcc gtc gat ccc gaa atc gat tcc gac att384Ile Val Ala Met Val Val Ser Val Asp Pro Glu Ile Asp Ser Asp Ile115 120 125cct gca atg ttg ggc gcg tct gcc gcg ctg gtg ttg agc ggc gta ccg432Pro Ala Met Leu Gly Ala Ser Ala Ala Leu Val Leu Ser Gly Val Pro130 135 140ttt gcc ggt ccg att ggt gcg gca cgc gtg ggt tat ata aac ggc gtg480Phe Ala Gly Pro Ile Gly Ala Ala Arg Val Gly Tyr Ile Asn Gly Val145 150 155 160tac gtt ttg aac ccg act aaa gcc gaa ttg gcg aaa tcg caa ttg gac528Tyr Val Leu Asn Pro Thr Lys Ala Glu Leu Ala Lys Ser Gln Leu Asp165 170 175ttg gtg gtc gcc ggt act tca aaa gcc gtg ttg atg gtg gaa tcc gaa576Leu Val Val Ala Gly Thr Ser Lys Ala Val Leu Met Val Glu Ser Glu180 185 190gcc aaa atc ctg ccc gaa gac gtg atg ctg ggc gcg gtg gtt tac ggc624Ala Lys Ile Leu Pro Glu Asp Val Met Leu Gly Ala Val Val Tyr Gly195 200 205cac gat caa atg cag gtt gcc atc aat gca atc aat gaa ttt gcc gac672His Asp Gln Met GLn Val Ala Ile Asn Ala Ile Asn Glu Phe Ala Asp210 215 220
gaa gtc aat ccg gaa ctt tgg gat tgg aaa gca cct gaa acc aat gag720Glu Val Asn Pro Glu Leu Trp Asp Trp Lys Ala Pro Glu Thr Asn Glu225 230 235 240gaa ctg gtt gcc aaa gtc cgc ggg att gcc ggc gaa acc att aaa gaa768Glu Leu Val Ala Lys Val Arg Gly Ile Ala Gly Glu Thr Ile Lys Glu245 250 255gcg ttc aaa atc cgt caa aaa caa gcg cgt tct gcc aaa ttg gac gaa816Ala Phe Lys Ile Arg Gln Lys Gln Ala Arg Ser Ala Lys Leu Asp Glu260 265 270gct tgg agt gcg gta aaa gaa gcc ttg att acc gaa gaa acc gac acg864Ala Trp Ser Ala Val Lys Glu Ala Leu Ile Thr Glu Glu Thr Asp Thr275 280 285ctg gca gcc aac gaa atc aaa ggc att ttc aaa cac ttg gaa gcc gat912Leu Ala Ala Asn Glu Ile Lys Gly Ile Phe Lys His Leu Glu Ala Asp2902 95 300gtc gtc cgc agc caa att ttg gac ggc caa ccg cgc atc gac ggc cgc960Val Val Arg Ser Gln Ile Leu Asp Gly Gln Pro Arg Ile Asp Gly Arg3053 10 315 320gac acc cgc acc gtc cgt ccg ctg aac atc caa acc ggc gta ttg ccg1008Asp Thr Arg Thr Val Arg Pro Leu Asn Ile Gln Thr Gly Val Leu Pro325 330 335cgc acg cac ggt tcc gca ttg ttt acc cgt ggc gaa acc caa gcc ctt1056Arg Thr His Gly Ser Ala Leu Phe Thr Arg Gly Glu Thr Gln Ala Leu340 345 350gcc gta gcg act ttg ggt act tcg cgc gac gag caa atc atc gac gcg1104Ala Val Ala Thr Leu Gly Thr Ser Arg Asp Glu Gln Ile Ile Asp Ala355 360 365ctg tcc ggc gaa tac acc gac cgc ttt atg ctg cac tac aac ttt ccg1152Leu Ser Gly Glu Tyr Thr Asp Arg Phe Met Leu His Tyr Asn Phe Pro370 375 380ccg tac tct acc ggc gaa gtg ggc cgc atg ggc gcg ccg aaa cgc cgt1200Pro Tyr Ser Thr Gly Glu Val Gly Arg Met Gly Ala Pro Lys Arg Arg385 390 395 400gaa atc ggt cac ggt cgt ttg gct aaa cgt gca ttg ttg gcc gta ttg1248Glu Ile Gly His Gly Arg Leu Ala Lys Arg Ala Leu Leu Ala Val Leu405 410 415
ccg aaa cct gaa gat ttc agc tac acc atg cgc gtg gtc tcc gaa att1296Pro Lys Pro Glu Asp Phe Ser Tyr Thr Met Arg Val Val Ser Glu Ile420 425 430acc gaa tcc aac ggc tct tcc tct atg gct tcc gtc tgc ggc ggc tgc1344Thr Glu Ser Asn Gly Ser Ser Ser Met Ala Ser Val Cys Gly Gly Cys435 440 445ttg agc ctg ctg tcc gcc ggc gtg cct ttg aaa gca cac gtt gcc ggt1392Leu Ser Leu Leu Ser Ala Gly Val Pro Leu Lys Ala His Val Ala Gly450 455 460atc gcg atg ggt ctg att ctg gaa ggc aat aag ttt gcc gtc ctg acc1440Ile Ala Met Gly Leu Ile Leu Glu Gly Asn Lys Phe Ala Val Leu Thr465 470 475 480gac att ttg ggc gac gaa gac cac ttg ggc gat atg gac ttt aaa gtg1488Asp Ile Leu Gly Asp Glu Asp His Leu Gly Asp Met Asp Phe Lys Val485 490 495gct ggt acg acc gaa ggc gtt acc gcg ctg caa atg gac atc aaa atc1536Ala Gly Thr Thr Glu Gly Val Thr Ala Leu Gln Met Asp Ile Lys Ile500 505 510caa ggc att acc aaa gag att atg caa atc gct ttg gcg cag gcc aaa1584Gln Gly Ile Thr Lys Glu Ile Met Gln Ile Ala Leu Ala Gln Ala Lys515 520 525gaa gcg cgt ctg cac atc ttg gat cag atg aaa gcc gcc gtt gcg ggc1632Glu Ala Arg Leu His Ile Leu Asp Gln Met Lys Ala Ala Val Ala Gly530 535 540ccg caa gag ctg tcc gca cac gcg cca cgc ttg ttc acg atg aaa atc1680Pro Gln Glu Leu Ser Ala His Ala Pro Arg Leu Phe Thr Met Lys Ile545 550 555 560aac caa gac aaa atc cgc gaa gtt atc ggt aag ggc ggt gaa acc atc1728Asn Gln Asp Lys Ile Arg Glu Val Ile Gly Lys Gly Gly Glu Thr Ile565 570 575cgt gcg att acc gct gaa acc ggt acg gaa atc aat att gcc gaa gac1776Arg Ala Ile Thr Ala Glu Thr Gly Thr Glu Ile Asn Ile Ala Glu Asp580 585 590ggt acg att acc att gcc gca acc act caa gaa gcc ggc gat gcg gcg1824Gly Thr Ile Thr Ile Ala Ala Thr Thr Gln Glu Ala Gly Asp Ala Ala595 600 605
aaa aaa cgc atc gag cag att act gcc gaa gtg gaagtg ggc aaa gtg1872Lys Lys Arg Ile Glu Gln Ile Thr Ala Glu Val Glu Val Gly Lys Val610 615 620tac gaa ggc act gtg gtg aaa atc ctc gac aac aat gtc ggc gcg att1920Tyr Glu Gly Thr Val Val Lys Ile Leu Asp Asn Asn Val Gly Ala Ile625 630 635 640gtc agt gtg atg ccg ggc aaa gac ggt ttg gta cac atc agc caa atc1968Val Ser Val Met Pro Gly Lys Asp Gly Leu Val His Ile Ser Gln Ile645 650 655gcc cac gag cgc gta cgc aat gtc ggc gac tac ctg caa gtc ggt cag2016Ala His Glu Arg Val Arg Asn Val Gly Asp Tyr Leu Gln Val Gly Gln660 665 670gtg gtg aac gtg aaa gca ttg gaa gtg gac gac aga ggc cgt gtc cgt2064Val Val Asn Val Lys Ala Leu Glu Val Asp Asp Arg Gly Arg Val Arg675 680 685ctg tcc atc aaa gcc ctg ctg gac gcg cct gcc cgt gag gaa aat gcc2112Leu Ser Ile Lys Ala Leu Leu Asp Ala Pro Ala Arg Glu Glu Asn Ala690 695 700gcc gag2118Ala Glu705<210>36<211>706<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>36Met Phe Asp Lys His Val Lys Thr Phe Gln Tyr Gly Asn Gln Thr Val1 5 10 15Thr Leu Glu Thr Gly Glu Ile Ala Arg Gln Ala Ala Ala Ala Val Lys20 25 30Val Ser Met Gly Asp Thr Val Val Leu Val Ala Val Thr Thr Asn Lys35 40 45Glu Val Lys Glu Gly Gln Asp Phe Phe Pro Leu Thr Val Asp Tyr Leu50 55 60Glu Arg Thr Tyr Ala Ala Gly Lys Ile Pro Gly Gly Phe Phe Lys Arg
65 70 75 80Glu Gly Lys Gln Ser Glu Lys Glu Ile Leu Thr Ser Arg Leu Ile Asp85 90 95Arg Pro Ile Arg Pro Leu Phe Pro Glu Gly Phe Tyr His Asp Ile Gln100 105 110Ile Val Ala Met Val Val Ser Val Asp Pro Glu Ile Asp Ser Asp Ile115 120 125Pro Ala Met Leu Gly Ala Ser Ala Ala Leu Val Leu Ser Gly Val Pro130 135 140Phe Ala Gly Pro Ile Gly Ala Ala Arg Val Gly Tyr Ile Asn Gly Val145 150 155 160Tyr Val Leu Asn Pro Thr Lys Ala Glu Leu Ala Lys Ser Gln Leu Asp165 170 175Leu Val Val Ala Gly Thr Ser Lys Ala Val Leu Met Val Glu Ser Glu180 185 190Ala Lys Ile Leu Pro Glu Asp Val Met Leu Gly Ala Val Val Tyr Gly195 200 205His Asp Gln Met Gln Val Ala Ile Asn Ala Ile Asn Glu Phe Ala Asp210 215 220Glu Val Asn Pro Glu Leu Trp Asp Trp Lys Ala Pro Glu Thr Asn Glu225 230 235 240Glu Leu Val Ala Lys Val Arg Gly Ile Ala Gly Glu Thr Ile Lys Glu245 250 255Ala Phe Lys Ile Arg Gln Lys Gln Ala Arg Ser Ala Lys Leu Asp Glu260 265 270Ala Trp Ser Ala Val Lys Glu Ala Leu Ile Thr Glu Glu Thr Asp Thr275 280 285Leu Ala Ala Asn Glu Ile Lys Gly Ile Phe Lys His Leu Glu Ala Asp290 295 300Val Val Arg Ser Gln Ile Leu Asp Gly Gln Pro Arg Ile Asp Gly Arg305 310 315 320Asp Thr Arg Thr Val Arg Pro Leu Asn Ile Gln Thr Gly Val Leu Pro
325 330 335Arg Thr His Gly Ser Ala Leu Phe Thr Arg Gly Glu Thr Gln Ala Leu340 345 350Ala Val Ala Thr Leu Gly Thr Ser Arg Asp Glu Gln Ile Ile Asp Ala355 360 365Leu Ser Gly Glu Tyr Thr Asp Arg Phe Met Leu His Tyr Asn Phe Pro370 375 380Pro Tyr Ser Thr Gly Glu Val Gly Arg Met Gly Ala Pro Lys Arg Arg385 390 395 400Glu Ile Gly His Gly Arg Leu Ala Lys Arg Ala Leu Leu Ala Val Leu405 410 415Pro Lys Pro Glu Asp Phe Ser Tyr Thr Met Arg Val Val Ser Glu Ile420 425 430Thr Glu Ser Asn Gly Ser Ser Ser Met Ala Ser Val Cys Gly Gly Cys435 440 445Leu Ser Leu Leu Ser Ala Gly Val Pro Leu Lys Ala His Val Ala Gly450 455 460Ile Ala Met Gly Leu Ile Leu Glu Gly Asn Lys Phe Ala Val Leu Thr465 470 475 480Asp Ile Leu Gly Asp Glu Asp His Leu Gly Asp Met Asp Phe Lys Val485 490 495Ala Gly Thr Thr Glu Gly Val Thr Ala Leu Gln Met Asp Ile Lys Ile500 505 510Gln Gly Ile Thr Lys Glu Ile Met Gln Ile Ala Leu Ala Gln Ala Lys515 520 525Glu Ala Arg Leu His Ile Leu Asp Gln Met Lys Ala Ala Val Ala Gly530 535 540Pro Gln Glu Leu Ser Ala His Ala Pro Arg Leu Phe Thr Met Lys Ile545 550 555 560Asn Gln Asp Lys Ile Arg Glu Val Ile Gly Lys Gly Gly Glu Thr Ile565 570 575Arg Ala Ile Thr Ala Glu Thr Gly Thr Glu Ile Asn Ile Ala Glu Asp
580 585 590Gly Thr Ile Thr Ile Ala Ala Thr Thr Gln Glu Ala Gly Asp Ala Ala595 600 605Lys Lys Arg Ile Glu Gln Ile Thr Ala Glu Val Glu Val Gly Lys Val610 615 620Tyr Glu Gly Thr Val Val Lys Ile Leu Asp Asn Asn Val Gly Ala Ile625 630 635 640Val Ser Val Met Pro Gly Lys Asp Gly Leu Val His Ile Ser Gln Ile645 650 655Ala His Glu Arg Val Arg Asn Val Gly Asp Tyr Leu Gln Val Gly Gln660 665 670Val Val Asn Val Lys Ala Leu Glu Val Asp Asp Arg Gly Arg Val Arg675 680 685Leu Ser Ile Lys Ala Leu Leu Asp Ala Pro Ala Arg Glu Glu Asn Ala690 695 700Ala Glu705<210>37<211>3972<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(3972)<400>37gtg agc cga att atg tct gtc gtt ttg ccc ttg cgc ggc gtt acc gcc48Val Ser Arg Ile Met Ser Val Val Leu Pro Leu Arg Gly Val Thr Ala1 5 10 15ctt tcc gat ttc cgt gtt gaa aaa ctc ttg caa aaa gcc gcc gca ctc96Leu Ser Asp Phe Arg Val Glu Lys Leu Leu Gln Lys Ala Ala Ala Leu20 25 30ggt ctg ccc gaa gtc aaa tta agc agc gaa ttt tgg tat ttc gtc ggc144Gly Leu Pro Glu Val Lys Leu Ser Ser Glu Phe Trp Tyr Phe Val Gly
35 40 45agc gag aaa gca ctt gat gcc gcg act gtc gaa aaa ctg caa gcc ttg192Ser Glu Lys Ala Leu Asp Ala Ala Thr Val Glu Lys Leu Gln Ala Leu50 55 60ttg gcg gcg caa agc gtt gaa caa acg cca aaa gcg cgc gag ggc ttg240Leu Ala Ala Gln Ser Val Glu Gln Thr Pro Lys Ala Arg Glu Gly Leu65 70 75 80cat ttg ttt ttg gtc acg ccc cgt ttg ggt acg att tcg ccg tgg gct288His Leu Phe Leu Val Thr Pro Arg Leu Gly Thr Ile Ser Pro Trp Ala85 90 95tcc aag gcg acc aat atc gcg gaa aac tgc ggt ttg gca ggc atc gaa336Ser Lys Ala Thr Asn Ile Ala Glu Asn Cys Gly Leu Ala Gly Ile Glu100 105 110cgc atc gag cgc ggc atg gcg gtg tgg ctg gaa ggt gcg ctt acc gat384Arg Ile Glu Arg Gly Met Ala Val Trp Leu Glu Gly Ala Leu Thr Asp115 120 125gaa cag caa cag caa tgg gcg gct ttg ctg cac gac cgc atg act gaa432Glu Gln Gln Gln Gln Trp Ala Ala Leu Leu His Asp Arg Met Thr Glu130 135 140tcc gtg ctg ccc gat ttt cag acg gca tcc aaa tta ttc cac cat ctc480Ser Val Leu Pro Asp Phe Gln Thr Ala Ser Lys Leu Phe His His Leu145 150 155 160gaa tcc gaa acc ttt tcc acc gtc gat gtt ttg ggc ggc ggt aaa gag528Glu Ser Glu Thr Phe Ser Thr Val Asp Val Leu Gly Gly Gly Lys Glu165 170 175gct ttg gtc aaa gcc aat acc gaa atg ggt ttg gca ctc tcc gcc gac576Ala Leu Val Lys Ala Asn Thr Glu Met Gly Leu Ala Leu Ser Ala Asp180 185 190gaa atc gat tat ctg gtt gaa aac tat cag gct ttg cag cgc aat ccg624Glu Ile Asp Tyr Leu Val Glu Asn Tyr Gln Ala Leu Gln Arg Asn Pro195 200 205tct gat gtg gag ctg atg atg ttc gcg cag gca aac agc gaa cac tgc672Ser Asp Val Glu Leu Met Met Phe Ala Gln Ala Asn Ser Glu His Cys210 215 220cgc cac aaa atc ttc aac gcc gac ttc atc ctc aac ggc gaa aaa cag720Arg His Lys Ile Phe Asn Ala Asp Phe Ile Leu Asn Gly Glu Lys Gln
225 230 235 240ccg aaa tcg ctc ttc ggt atg ata cgc gac acg cac aac gcg cat ccc768Pro Lys Ser Leu Phe Gly Met Ile Arg Asp Thr His Asn Ala His Pro245 250 255gaa ggc aca gtc gtt gcc tac aaa gac aac tca tcc gtg atc gaa ggc816Glu Gly Thr Val Val Ala Tyr Lys Asp Asn Ser Ser Val Ile Glu Gly260 265 270gca aaa gtc gaa cgt ttc tat cca aat gcg gca gaa aac caa ggc tac864Ala Lys Val Glu Arg Phe Tyr Pro Asn Ala Ala Glu Asn Gln Gly Tyr275 280 285cgt ttc cac gag gaa gac acg cat atc atc atg aaa gtg gaa acg cac912Arg Phe His Glu Glu Asp Thr His Ile Ile Met Lys Val Glu Thr His290 295 300aac cac ccg acc gcc atc gcg ccg ttt gcg ggc gcg gca acg ggc gcg960Asn His Pro Thr Ala Ile Ala Pro Phe Ala Gly Ala Ala Thr Gly Ala305 310 315 320ggc ggc gaa atc cgc gac gaa ggt gcg acg ggc aaa ggt tcg cgt ccg1008Gly Gly Glu Ile Arg Asp Glu Gly Ala Thr Gly Lys Gly Ser Arg Pro325 330 335aaa gca ggc ttg acc ggc ttt acc gtg tcc aac ctc aac atc ccc ggc1056Lys Ala Gly Leu Thr Gly Phe Thr Val Ser Asn Leu Asn Ile Pro Gly340 345 350ctc aaa cag ccg tgg gaa caa gat tac ggc aag ccg gaa cat att tcc1104Leu Lys Gln Pro Trp Glu Gln Asp Tyr Gly Lys Pro Glu His Ile Ser355 360 365tcg ccg ctg gac att atg att gaa ggc ccc atc ggc ggc gcg gcg ttc1152Ser Pro Leu Asp Ile Met Ile Glu Gly Pro Ile Gly Gly Ala Ala Phe370 375 380aac aac gaa ttc ggc cgc ccc aac ctc ttg ggc tac ttc cgc act ttt1200Asn Asn Glu Phe Gly Arg Pro Asn Leu Leu Gly Tyr Phe Arg Thr Phe385 390 395 400gaa gaa aaa ttt gac ggt cag gtt cgc ggc tac cac aaa ccg att atg1248Glu Glu Lys Phe Asp Gly Gln Val Arg Gly Tyr His Lys Pro Ile Met405 410 415att gcc ggc ggc ttg ggc agc att cag gcg cag cag acg cat aaa gac1296Ile Ala Gly Gly Leu Gly Ser Ile Gln Ala Gln Gln Thr His Lys Asp
420 425 430gaa atc ccc gaa ggc gcg ttg ctg atc caa ctg ggc ggc ccg ggt atg1344Glu Ile Pro Glu Gly Ala Leu Leu Ile Gln Leu Gly Gly Pro Gly Met435 440 445ctt atc ggc ttg ggc ggc ggc gcg gct tct tcg atg gat acc ggc aca1392Leu Ile Gly Leu Gly Gly Gly Ala Ala Ser Ser Met Asp Thr Gly Thr450 455 460aac gac gcg tct tta gac ttc aac tcc gta caa cgc ggc aac ccc gaa1440Asn Asp Ala Ser Leu Asp Phe Asn Ser Val Gln Arg Gly Asn Pro Glu465 470 475 480atc gaa cgc cgc gcg cag gaa gtg atc gac cgc tgc tgg cag ctc ggc1488Ile Glu Arg Arg Ala Gln Glu Val Ile Asp Arg Cys Trp Gln Leu Gly485 490 495gac aaa aac ccg att atc tcc atc cac gac gtt ggc gcg ggc ggc ttg1536Asp Lys Asn Pro Ile Ile Ser Ile His Asp Val Gly Ala Gly Gly Leu500 505 510tcc aac gcc ttc ccc gaa ctc gtc aac gat gcc gga cgc ggc gcg gta1584Ser Asn Ala Phe Pro Glu Leu Val Asn Asp Ala Gly Arg Gly Ala Val515 520 525ttc aag ctg cgc gaa gtg ccg ctg gaa gaa cac ggt ctc aac ccg ctg1632Phe Lys Leu Arg Glu Val Pro Leu Glu Glu His Gly Leu Asn Pro Leu530 535 540caa atc tgg tgc aac gaa tcg caa gag cgt tat gta ttg tcg att ttg1680Gln Ile Trp Cys Asn Glu Ser Gln Glu Arg Tyr Val Leu Ser Ile Leu545 550 555 560gaa aaa gat ttg gac atc ttc cgc tcc atc tgc gaa cgt gaa cgc tgc1728Glu Lys Asp Leu Asp Ile Phe Arg Ser Ile Cys Glu Arg Glu Arg Cys565 570 575ccg ttt gcg gta gtc ggt acg gcg acc gac gac ggc cat ttg aaa gta1776Pro Phe Ala Val Val Gly Thr Ala Thr Asp Asp Gly His Leu Lys Val580 585 590cgc gac gat ttg ttc tcc aac aac cct gtc gat ttg ccg ttg aac gtc1824Arg Asp Asp Leu Phe Ser Asn Asn Pro Val Asp Leu Pro Leu Asn Val595 600 605ttg ctc ggc aaa ccg ccc aaa acc acg cgt acc gac aaa acg gtt gcg1872Leu Leu Gly Lys Pro Pro Lys Thr Thr Arg Thr Asp Lys Thr Val Ala
610 615 620ccg tcc aaa aaa ccg ttt cac gcg ggc gat atc gac att act gaa gcc1920Pro Ser Lys Lys Pro Phe His Ala Gly Asp Ile Asp Ile Thr Glu Ala625 630 635 640gcc tac cgc gtt ctg cgc ctg cct gcc gta gcc gcc aaa aac ttc ctg1968Ala Tyr Arg Val Leu Arg Leu Pro Ala Val Ala Ala Lys Asn Phe Leu645 650 655att acc atc ggc gac cgc agc gtc ggc ggc atg acc cac cgc gac caa2016Ile Thr Ile Gly Asp Arg Ser Val Gly Gly Met Thr His Arg Asp Gln660 665 670atg gtc ggc aaa tac caa acc ccc gta gcc gac tgc gcc gtt acc atg2064Met Val Gly Lys Tyr Gln Thr Pro Val Ala Asp Cys Ala Val Thr Met675 680 685atg ggc ttc aac act tat cgc ggc gaa gcg atg agc atg ggc gaa aaa2112Met Gly Phe Asn Thr Tyr Arg Gly Glu Ala Met Ser Met Gly Glu Lys690 695 700ccg acc gtc gcc ctg ttt gac gcg cct gct tcg ggc aga atg tgc gtc2160Pro Thr Val Ala Leu Phe Asp Ala Pro Ala Ser Gly Arg Met Cys Val705 710 715 720ggc gaa gcc atc acc aac atc gcg gca gcc aat atc ggc gac atc ggc2208Gly Glu Ala Ile Thr Asn Ile Ala Ala Ala Asn Ile Gly Asp Ile Gly725 730 735aac atc aaa ctc tcc gcc aac tgg atg gcg gcg tgc ggc aac gaa ggc2256Asn Ile Lys Leu Ser Ala Asn Trp Met Ala Ala Cys Gly Asn Glu Gly740 745 750gaa gac gaa aaa ctc tac cgc acc gtc gaa gcg gtt tcc aaa gcc tgt2304Glu Asp Glu Lys Leu Tyr Arg Thr Val Glu Ala Val Ser Lys Ala Cys755 760 765cag gca ttg gat ttg agc att ccc gtg ggc aaa gac agc ctg tcg atg2352Gln Ala Leu Asp Leu Ser Ile Pro Val Gly Lys Asp Ser Leu Ser Met770 775 780aaa acc gtg tgg cag gac ggc gaa gag aaa aaa tcc gtc gtt tcg ccg2400Lys Thr Val Trp Gln Asp Gly Glu Glu Lys Lys Ser Val Val Ser Pro785 790 795 800ttg agc ctg att atc tcc gcg ttc gcg ccg gtt caa gac gta cgc aaa2448Leu Ser Leu Ile Ile Ser Ala Phe Ala Pro Val Gln Asp Val Arg Lys
805 810 815acc gtt acg ccc gaa ttg aaa aac gtc gag gac agc gta ttg ctg ttt2496Thr Val Thr Pro Glu Leu Lys Asn Val Glu Asp Ser Val Leu Leu Phe820 825 830gtc gat ttg ggc ttc ggc aaa gcg cgt atg ggc ggc tcg gcg ttt ggt2544Val Asp Leu Gly Phe Gly Lys Ala Arg Met Gly Gly Ser Ala Phe Gly835 840 845cag gtg tac aac aat atg agc ggc gac gcg ccc gat ttg gac gat aca2592Gln Val Tyr Asn Asn Met Ser Gly Asp Ala Pro Asp Leu Asp Asp Thr850 855 860agt cgt ctg aaa gcg ttt tac aac gtg att cag cag ctt gtc gcc gaa2640Ser Arg Leu Lys Ala Phe Tyr Asn Val Ile Gln Gln Leu Val Ala Glu865 870 875 880gac aaa ctc ttg gcg tat cac gac cgc agc gac ggc ggc ttg ttt gcc2688Asp Lys Leu Leu Ala Tyr His Asp Arg Ser Asp Gly Gly Leu Phe Ala885 890 895gtt ttg gta gaa atg gcg ttt gca ggg cgg tgc ggc ttg gat ata gat2736Val Leu Val Glu Met Ala Phe Ala Gly Arg Cys Gly Leu Asp Ile Asp900 905 910tta aat tta ttg ctt gca caa aca ttt att acc aac cat acc gct ctg2784Leu Asn Leu Leu Leu Ala Gln Thr Phe Ile Thr Asn His Thr Ala Leu915 920 925tct caa tca ttg cgg act gaa gag gta aaa gcg ttg gct gaa tgg caa2832Ser Gln Ser Leu Arg Thr Glu Glu Val Lys Ala Leu Ala Glu Trp Gln930 935 940gaa acc att gcc cgc aca tta ttt aat gaa gag ttg ggt gct gtt atc2880Glu Thr Ile Ala Arg Thr Leu Phe Asn Glu Glu Leu Gly Ala Val Ile945 950 955 960caa gtt aga aaa caa gat gtt gcc gat att atc aat tta ttc tat caa2928Gln Val Arg Lys Gln Asp Val Ala Asp Ile Ile Asn Leu Phe Tyr Gln965 970 975caa cag ctg cat cat aat gtc ttt gaa atc ggt acg tta act gat gag2976Gln Gln Leu His His Asn Val Phe Glu Ile Gly Thr Leu Thr Asp Glu980 985 990aac acg tta atc atc cgc gac ggg caa acg cac ctt att tct gac aac3024Asn Thr Leu Ile Ile Arg Asp Gly Gln Thr His Leu Ile Ser Asp Asn
99510001005cta atc aaa ctg caa caa acc tgg caa gaa acc agc cat caa atc caa3072Leu Ile Lys Leu Gln Gln Thr Trp Gln Glu Thr Ser His Gln Ile Gln101010151020cgc ctg cgc gac aac cct gcc tgc gcc gac agc gag ttt gcc ctg att3120Arg Leu Arg Asp Asn Pro Ala Cys Ala Asp Ser Glu Phe Ala Leu Ile1025 103010351040ggc gac aac gga cgc agc gca ttg ttt gcc aac ctg aaa ttc gac gtg3168Gly Asp Asn Gly Arg Ser Ala Leu Phe Ala Asn Leu Lys Phe Asp Val104510501055aac gaa gac atc gcc gcg ccg ttt atc aac agc ggc gcg aaa ccc aaa3216Asn Glu Asp Ile Ala Ala Pro Phe Ile Asn Ser Gly Ala Lys Pro Lys106010651070atc gcc atc ctg cgc gaa cag ggc gta aac ggg caa atc gaa atg gcc3264Ile Ala Ile Leu Arg Glu Gln Gly Val Asn Gly Gln Ile Glu Met Ala107510801085gcc gcc ttc acc cgt gcc ggt ttc gat gcc tac gac gtg cat atg tcc3312Ala Ala Phe Thr Arg Ala Gly Phe Asp Ala Tyr Asp Val His Met Ser109010951100gac ctg atg gca ggc cgc gtc cac ctt gcc gac ttc aaa atg ctg gcg3360Asp Leu Met Ala Gly Arg Val His Leu Ala Asp Phe Lys Met Leu Ala1105 111011151120gcg tgc ggc ggc ttc agc tac ggc gac gta ctc ggc gcg ggc aaa ggc3408Ala Cys Gly Gly Phe Ser Tyr Gly Asp Val Leu Gly Ala Gly Lys Gly112511301135tgg gcg aaa tcc atc ctg ttc cac ccc gcc tta cgc gac cag ttc gcc3456Trp Ala Lys Ser Ile Leu Phe His Pro Ala Leu Arg Asp Gln Phe Ala114011451150gcc ttc ttc acc gac ccg aac acg ctg aca ttg ggc gtg tgc aac ggc3504Ala Phe Phe Thr Asp Pro Asn Thr Leu Thr Leu Gly Val Cys Asn Gly115511601165tgc cag atg gtc agc aac ctc gcc gaa atc atc ccc ggc acg gca ggc3552Cys Gln Met Val Ser Asn Leu Ala Glu Ile Ile Pro Gly Thr Ala Gly117011751180tgg ccg aag ttc aag cgc aac ctg agc gaa cag ttc gaa gcg cgc ctg3600Trp Pro Lys Phe Lys Arg Asn Leu Ser Glu Gln Phe Glu Ala Arg Leu
1185 119011951200agc atg gtt cac gtc ccc aaa tca gcc tcc ctg att ctg aac gaa atg3648Ser Met Val His Val Pro Lys Ser Ala Ser Leu Ile Leu Asn Glu Met120512101215caa ggc tcc agc ctg ccc gtc gtc gtc agc cac ggc gaa ggc cgc gcc3696Gln Gly Ser Ser Leu Pro Val Val Val Ser His Gly Glu Gly Arg Ala122012251230gac ttc gcg ctt cac ggc ggc aac att tct gcc gat ttg ggc att gcg3744Asp Phe Ala Leu His Gly Gly Asn Ile Ser Ala Asp Leu Gly Ile Ala123512401245ttg caa tat gtg gac gga caa aac caa att acc caa acc tac ccg ctc3792Leu Gln Tyr Val Asp Gly Gln Asn Gln Ile Thr Gln Thr Tyr Pro Leu125012551260aac ccc aac ggc tcg ccg caa ggc atc gcc ggc gtg acc aac gcc gac3840Asn Pro Asn Gly Ser Pro Gln Gly Ile Ala Gly Val Thr Asn Ala Asp1265 127012751280ggc cgc gtt acc atc atg atg ccg cat cct gaa cgt gta tac cgc gcc3888Gly Arg Val Thr Ile Met Met Pro His Pro Glu Arg Val Tyr Arg Ala128512901295gca caa atg agc tgg aaa ccg gaa gac tgg acg gaa ttg tcc ggc tgg3936Ala Gln Met Ser Trp Lys Pro Glu Asp Trp Thr Glu Leu Ser Gly Trp130013051310tac cgc ctc ttc gcc ggc gca cgt aaa gcc ttg ggc3972Tyr Arg Leu Phe Ala Gly Ala Arg Lys Ala Leu Gly13151320<210>38<211>1324<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>38Val Ser Arg Ile Met Ser Val Val Leu Pro Leu Arg Gly Val Thr Ala1 5 10 15Leu Ser Asp Phe Arg Val Glu Lys Leu Leu Gln Lys Ala Ala Ala Leu20 25 30Gly Leu Pro Glu Val Lys Leu Ser Ser Glu Phe Trp Tyr Phe Val Gly
35 40 45Ser Glu Lys Ala Leu Asp Ala Ala Thr Val Glu Lys Leu Gln Ala Leu50 55 60Leu Ala Ala Gln Ser Val Glu Gln Thr Pro Lys Ala Arg Glu Gly Leu65 70 75 80His Leu Phe Leu Val Thr Pro Arg Leu Gly Thr Ile Ser Pro Trp Ala85 90 95Ser Lys Ala Thr Asn Ile Ala Glu Asn cys Gly Leu Ala Gly Ile Glu100 105 110Arg Ile Glu Arg Gly Met Ala Val Trp Leu Glu Gly Ala Leu Thr Asp115 120 125Glu Gln Gln Gln Gln Trp Ala Ala Leu Leu His Asp Arg Met Thr Glu130 135 140Ser Val Leu Pro Asp Phe Gln Thr Ala Ser Lys Leu Phe His His Leu145 150 155 160Glu Ser Glu Thr Phe Ser Thr Val Asp Val Leu Gly Gly Gly Lys Glu165 170 175Ala Leu Val Lys Ala Asn Thr Glu Met Gly Leu Ala Leu Ser Ala Asp180 185 190Glu Ile Asp Tyr Leu Val Glu Asn Tyr Gln Ala Leu Gln Arg Asn Pro195 200 205Ser Asp Val Glu Leu Met Met Phe Ala Gln Ala Asn Ser Glu His Cys210 215 220Arg His Lys Ile Phe Asn Ala Asp Phe Ile Leu Asn Gly Glu Lys Gln225 230 235 240Pro Lys Ser Leu Phe Gly Met Ile Arg Asp Thr His Asn Ala His Pro245 250 255Glu Gly Thr Val Val Ala Tyr Lys Asp Asn Ser Ser Val Ile Glu Gly260 265 270Ala Lys Val Glu Arg Phe Tyr Pro Asn Ala Ala Glu Asn Gln Gly Tyr275 280 285Arg Phe His Glu Glu Asp Thr His Ile Ile Met Lys Val Glu Thr His
290 295 300Asn His Pro Thr Ala Ile Ala Pro Phe Ala Gly Ala Ala Thr Gly Ala305 310 315 320Gly Gly Glu Ile Arg Asp Glu Gly Ala Thr Gly Lys Gly Ser Arg Pro325 330 335Lys Ala Gly Leu Thr Gly Phe Thr Val Ser Asn Leu Asn Ile Pro Gly340 345 350Leu Lys Gln Pro Trp Glu Gln Asp Tyr Gly Lys Pro Glu His Ile Ser355 360 365Ser Pro Leu Asp Ile Met Ile Glu Gly Pro Ile Gly Gly Ala Ala Phe370 375 380Asn Asn Glu Phe Gly Arg Pro Asn Leu Leu Gly Tyr Phe Arg Thr Phe385 390 395 400Glu Glu Lys Phe Asp Gly Gln Val Arg Gly Tyr His Lys Pro Ile Met405 410 415Ile Ala Gly Gly Leu Gly Ser Ile Gln Ala Gln Gln Thr His Lys Asp420 425 430Glu Ile Pro Glu Gly Ala Leu Leu Ile Gln Leu Gly Gly Pro Gly Met435 440 445Leu Ile Gly Leu Gly Gly Gly Ala Ala Ser Ser Met Asp Thr Gly Thr450 455 460Asn Asp Ala Ser Leu Asp Phe Asn Ser Val Gln Arg Gly Asn Pro Glu465 470 475 480Ile Glu Arg Arg Ala Gln Glu Val Ile Asp Arg Cys Trp Gln Leu Gly485 490 495Asp Lys Asn Pro Ile Ile Ser Ile His Asp Val Gly Ala Gly Gly Leu500 505 510Ser Asn Ala Phe Pro Glu Leu Val Asn Asp Ala Gly Arg Gly Ala Val515 520 525Phe Lys Leu Arg Glu Val Pro Leu Glu Glu His Gly Leu Asn Pro Leu530 535 540Gln Ile Trp Cys Asn Glu Ser Gln Glu Arg Tyr Val Leu Ser Ile Leu
545 550 555 560Glu Lys Asp Leu Asp Ile Phe Arg Ser Ile Cys Glu Arg Glu Arg Cys565 570 575Pro Phe Ala Val Val Gly Thr Ala Thr Asp Asp Gly His Leu Lys Val580 585 590Arg Asp Asp Leu Phe Ser Asn Asn Pro Val Asp Leu Pro Leu Asn Val595 600 605Leu Leu Gly Lys Pro Pro Lys Thr Thr Arg Thr Asp Lys Thr Val Ala610 615 620Pro Ser Lys Lys Pro Phe His Ala Gly Asp Ile Asp Ile Thr Glu Ala625 630 635 640Ala Tyr Arg Val Leu Arg Leu Pro Ala Val Ala Ala Lys Asn Phe Leu645 650 655Ile Thr Ile Gly Asp Arg Ser Val Gly Gly Met Thr His Arg Asp Gln660 665 670Met Val Gly Lys Tyr Gln Thr Pro Val Ala Asp Cys Ala Val Thr Met675 680 685Met Gly Phe Asn Thr Tyr Arg Gly Glu Ala Met Ser Met Gly Glu Lys690 695 700Pro Thr Val Ala Leu Phe Asp Ala Pro Ala Ser Gly Arg Met Cys Val705 710 715 720Gly Glu Ala Ile Thr Asn Ile Ala Ala Ala Asn Ile Gly Asp Ile Gly725 730 735Asn Ile Lys Leu Ser Ala Asn Trp Met Ala Ala Cys Gly Asn Glu Gly740 745 750Glu Asp Glu Lys Leu Tyr Arg Thr Val Glu Ala Val Ser Lys Ala Cys755 760 765Gln Ala Leu Asp Leu Ser Ile Pro Val Gly Lys Asp Ser Leu Ser Met770 775 780Lys Thr Val Trp Gln Asp Gly Glu Glu Lys Lys Ser Val Val Ser Pro785 790 795 800Leu Ser Leu Ile Ile Ser Ala Phe Ala Pro Val Gln Asp Val Arg Lys
805 810 815Thr Val Thr Pro Glu Leu Lys Asn Val Glu Asp Ser Val Leu Leu Phe820 825 830Val Asp Leu Gly Phe Gly Lys Ala Arg Met Gly Gly Ser Ala Phe Gly835 840 845Gln Val Tyr Asn Asn Met Ser Gly Asp Ala Pro Asp Leu Asp Asp Thr850 855 860Ser Arg Leu Lys Ala Phe Tyr Asn Val Ile Gln Gln Leu Val Ala Glu865 870 875 880Asp Lys Leu Leu Ala Tyr His Asp Arg Ser Asp Gly Gly Leu Phe Ala885 890 895Val Leu Val Glu Met Ala Phe Ala Gly Arg Cys Gly Leu Asp Ile Asp900 905 910Leu Asn Leu Leu Leu Ala Gln Thr Phe Ile Thr Asn His Thr Ala Leu915 920 925Ser Gln Ser Leu Arg Thr Glu Glu Val Lys Ala Leu Ala Glu Trp Gln930 935 940Glu Thr Ile Ala Arg Thr Leu Phe Asn Glu Glu Leu Gly Ala Val Ile945 950 955 960Gln Val Arg Lys Gln Asp Val Ala Asp Ile Ile Asn Leu Phe Tyr Gln965 970 975Gln Gln Leu His His Asn Val Phe Glu Ile Gly Thr Leu Thr Asp Glu980 985 990Asn Thr Leu Ile Ile Arg Asp Gly Gln Thr His Leu Ile Ser Asp Asn99510001005Leu Ile Lys Leu Gln Gln Thr Trp Gln Glu Thr Ser His Gln Ile Gln101010151020Arg Leu Arg Asp Asn Pro Ala Cys Ala Asp Ser Glu Phe Ala Leu Ile025103010351040Gly Asp Asn Gly Arg Ser Ala Leu Phe Ala Asn Leu Lys Phe Asp Val104510501055Asn Glu Asp Ile Ala Ala Pro Phe Ile Asn Ser Gly Ala Lys Pro Lys
106010651070Ile Ala Ile Leu Arg Glu Gln Gly Val Asn Gly Gln Ile Glu Met Ala107510801085Ala Ala Phe Thr Arg Ala Gly Phe Asp Ala Tyr Asp Val His Met Ser109010951100Asp Leu Met Ala Gly Arg Val His Leu Ala Asp Phe Lys Met Leu Ala105111011151120Ala Cys Gly Gly Phe Ser Tyr Gly Asp Val Leu Gly Ala Gly Lys Gly112511301135Trp Ala Lys Ser Ile Leu Phe His Pro Ala Leu Arg Asp Gln Phe Ala114011451150Ala Phe Phe Thr Asp Pro Asn Thr Leu Thr Leu Gly Val Cys Asn Gly115511601165Cys Gln Met Val Ser Asn Leu Ala Glu Ile Ile Pro Gly Thr Ala Gly117011751180Trp Pro Lys Phe Lys Arg Asn Leu Ser Glu Gln Phe Glu Ala Arg Leu185119011951200Ser Met Val His Val Pro Lys Ser Ala Ser Leu Ile Leu Asn Glu Met120512101215Gln Gly Ser Ser Leu Pro Val Val Val Ser His Gly Glu Gly Arg Ala122012251230Asp Phe Ala Leu His Gly Gly Asn Ile Ser Ala Asp Leu Gly Ile Ala123512401245Leu Gln Tyr Val Asp Gly Gln Asn Gln Ile Thr Gln Thr Tyr Pro Leu125012551260Asn Pro Asn Gly Ser Pro Gln Gly Ile Ala Gly Val Thr Asn Ala Asp265127012751280Gly Arg Val Thr Ile Met Met Pro His Pro Glu Arg Val Tyr Arg Ala128512901295Ala Gln Met Ser Trp Lys Pro Glu Asp Trp Thr Glu Leu Ser Gly Trp130013051310Tyr Arg Leu Phe Ala Gly Ala Arg Lys Ala Leu Gly
13151320<210>39<211>471<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(471)<400>39atg tcc cgc aat acc gaa gag ctg caa ggc atc tcg ctt ttg ggt aat48Met Ser Arg Asn Thr Glu Glu Leu Gln Gly Ile Ser Leu Leu Gly Asn1 5 10 15cag aaa acc cga tat ccg acc ggc tac gcg cct gaa att ctc gaa gca96Gln Lys Thr Arg Tyr Pro Thr Gly Tyr Ala Pro Glu Ile Leu Glu Ala20 25 30ttc gac aac aaa cat ccc gac aac gac tat ttc gtc aaa ttc gtc tgc144Phe Asp Asn Lys His Pro Asp Asn Asp Tyr Phe Val Lys Phe Val cys35 40 45cca gag ttc acc agc ctc tgc ccc atg acc ggg cag ccc gac ttc gcc192Pro Glu Phe Thr Ser Leu Cys Pro Met Thr Gly Gln Pro Asp Phe Ala50 55 60acc atc tac atc cgc tac att ccg cac atc aaa atg gtg gaa agc aaa240Thr Ile Tyr Ile Arg Tyr Ile Pro His Ile Lys Met Val Glu Ser Lys65 70 75 80tcc ctg aaa ctc tac ctc ttc agc ttc cgc aac cac ggc gat ttt cat288Ser Leu Lys Leu Tyr Leu Phe Ser Phe Arg Asn His Gly Asp Phe His85 90 95gaa gac tgc gtc aac atc atc atg aaa gac ctc att gcc ctg atg gat336Glu Asp Cys Val Asn Ile Ile Met Lys Asp Leu Ile Ala Leu Met Asp100 105 110ccg aaa tac atc gaa gta ttc ggc gag ttc aca ccg cgc ggc ggc atc384Pro Lys Tyr Ile Glu Val Phe Gly Glu Phe Thr Pro Arg Gly Gly Ile115 120 125gcc att cat cct ttc gcc aat tac ggc aaa gca ggc acc gag ttt gaa432Ala Ile His Pro Phe Ala Asn Tyr Gly Lys Ala Gly Thr Glu Phe Glu
130 135 140gca ttg gcg cgt aaa cgc ctg ttt gag cac gac gca caa471Ala Leu Ala Arg Lys Arg Leu Phe Glu His Asp Ala Gln145 150 155<210>40<211>157<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>40Met Ser Arg Asn Thr Glu Glu Leu Gln Gly Ile Ser Leu Leu Gly Asn1 5 10 15Gln Lys Thr Arg Tyr Pro Thr Gly Tyr Ala Pro Glu Ile Leu Glu Ala20 25 30Phe Asp Asn Lys His Pro Asp Asn Asp Tyr Phe Val Lys Phe Val Cys35 40 45Pro Glu Phe Thr Ser Leu Cys Pro Met Thr Gly Gln Pro Asp Phe Ala50 55 60Thr Ile Tyr Ile Arg Tyr Ile Pro His Ile Lys Met Val Glu Ser Lys65 70 75 80Ser Leu Lys Leu Tyr Leu Phe Ser Phe Arg Asn His Gly Asp Phe His85 90 95Glu Asp Cys Val Asn Ile Ile Met Lys Asp Leu Ile Ala Leu Met Asp100 105 110Pro Lys Tyr Ile Glu Val Phe Gly Glu Phe Thr Pro Arg Gly Gly Ile115 120 125Ala Ile His Pro Phe Ala Asn Tyr Gly Lys Ala Gly Thr Glu Phe Glu130 135 140Ala Leu Ala Arg Lys Arg Leu Phe Glu His Asp Ala Gln145 150 155<210>41<211>504<212>DNA
<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(504)<400>41atg ccc cta cta gac agt ttc aaa gtc gat cac acc cgt atg cat gcc48Met Pro Leu Leu Asp Ser Phe Lys Val Asp His Thr Arg Met His Ala1 5 10 15ccc gcc gta cgc gtg gcg aaa acc atg acc acg ccc aaa ggc gac acc96Pro Ala Val Arg Val Ala Lys Thr Met Thr Thr Pro Lys Gly Asp Thr20 25 30att acc gtg ttc gac ctg cgc ttt tgc gtt ccc aat aaa gaa atc ctg144Ile Thr Val Phe Asp Leu Arg Phe Cys Val Pro Asn Lys Glu Ile Leu35 40 45cct gaa aaa ggc ata cac acg ctg gag cat ttg ttc gca ggt ttt atg192Pro Glu Lys Gly Ile His Thr Leu Glu His Leu Phe Ala Gly Phe Met50 55 60cgc gac cac ttg aac ggc aac ggc gtg gaa atc atc gac att tcc ccg240Arg Asp His Leu Asn Gly Asn Gly Val Glu Ile Ile Asp Ile Ser Pro65 70 75 80atg ggc tgc cgc acc ggt ttt tat atg agc ctt atc ggc acg cct tcc288Met Gly Cys Arg Thr Gly Phe Tyr Met Ser Leu Ile Gly Thr Pro Ser85 90 95gaa cag cag gtc gcc gat gcg tgg ctg gct tcg atg cag gat gtt ttg336Glu Gln Gln Val Ala Asp Ala Trp Leu Ala Ser Met Gln Asp Val Leu100 105 110aat gtc aaa gac caa agc aaa atc ccc gag ttg aac gaa tac caa tgc384Asn Val Lys Asp Gln Ser Lys Ile Pro Glu Leu Asn Glu Tyr Gln Cys115 120 125ggc act tat caa atg cac tcg ctc gcc gaa gcg cag caa atc gcg caa432Gly Thr Tyr Gln Met His Ser Leu Ala Glu Ala Gln Gln Ile Ala Gln130 135 140aac gtg ttg gcg cgc aaa gtg gcg gtg aac aaa aat gaa gag ctg acg480Asn Val Leu Ala Arg Lys Val Ala Val Asn Lys Asn Glu Glu Leu Thr145 150 155 160ctg gat gaa ggg ctg ctg aac gcc504
Leu Asp Glu Gly Leu Leu Asn Ala165<210>42<211>168<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>42Met Pro Leu Leu Asp Ser Phe Lys Val Asp His Thr Arg Met His Ala1 5 10 15Pro Ala Val Arg Val Ala Lys Thr Met Thr Thr Pro Lys Gly Asp Thr20 25 30Ile Thr Val Phe Asp Leu Arg Phe Cys Val Pro Asn Lys Glu Ile Leu35 40 45Pro Glu Lys Gly Ile His Thr Leu Glu His Leu Phe Ala Gly Phe Met50 55 60Arg Asp His Leu Asn Gly Asn Gly Val Glu Ile Ile Asp Ile Ser Pro65 70 75 80Met Gly Cys Arg Thr Gly Phe Tyr Met Ser Leu Ile Gly Thr Pro Ser85 90 95Glu Gln Gln Val Ala Asp Ala Trp Leu Ala Ser Met Gln Asp Val Leu100 105 110Asn Val Lys Asp Gln Ser Lys Ile Pro Glu Leu Asn Glu Tyr Gln Cys115 120 125Gly Thr Tyr Gln Met His Ser Leu Ala Glu Ala Gln Gln Ile Ala Gln130 135 140Asn Val Leu Ala Arg Lys Val Ala Val Asn Lys Asn Glu Glu Leu Thr145 150 155 160Leu Asp Glu Gly Leu Leu Asn Ala165<210>43<211>813<212>DNA
<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(813)<400>43atg act atg cac gcc ctc ccc cgc tac gcc gtt ttt ggc aac ccc gtc48Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val1 5 10 15gcc cac agc aaa tcg ccg caa att cat caa caa ttt gcc ctt cag gaa96Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu20 25 30ggc gtt gac att gaa tac gaa cgc att tgc gcc gac atc ggc ggt ttc144Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe35 40 45gcg cag gcg gtt tcg aca ttt ttt gaa aca ggc ggt tgc ggg gca aac192Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn50 55 60gtt acc gta ccg ttc aag cag gaa gcg ttt cat ctg gcg gac gag cat240Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His65 70 75 80tct gaa cgc gca ttg gct gcc ggc gcg gtc aac acg ctg att ttt ctg288Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu85 90 95aaa aac gga aaa ctg cgc ggc gac aat acc gac ggt atc ggt ttg gcc336Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala100 105 110aac gac atc acg cag gtc aaa aac att gcc atc gaa ggc aaa acc atc384Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile115 120 125ttg ctt ttg ggc gcg ggc ggc gcg gtg cgc ggc gtg att cct gtt ttg432Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu130 135 140aaa gaa cac cgt cct gcc cgt atc gtc att gcc aac cgt acc cgc gcc480Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala145 150 155 160aaa gcc gag gaa ttg gcg cag ctt ttc ggc att gaa gcc gtc ccg atg528
Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met165 170 175gcg gat gtg aac ggc ggt ttt gat atc atc atc aac ggc acg tcg ggc576Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly180 185 190ggt cta aac ggt cag att ccc gat att ccg ccc gat att ttt caa aac624Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn195 200 205tgc gcg ctt gcc tac gat atg gtg tac ggc tgc gcg gca aaa ccg ttt672Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe210 215 220tta gat ttt gca cga caa tcg ggt gcg aaa aaa act gcc gac gga ctg720Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu225 230 235 240ggt atg cta gtc ggt caa gcg gcg gct tcc tac gcc ctc tgg cgc gga768Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly245 250 255ttt acg ccc gat atc cgc ccc gtt atc gaa tac atg aaa gcc cta813Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala Leu260 265 270<210>44<211>271<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>44Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val1 5 10 15Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu20 25 30Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe35 40 45Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn50 55 60Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His65 70 75 80
Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu85 90 95Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala100 105 110Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile115 120 125Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu130 135 140Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala145 150 155 160Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met165 170 175Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly180 185 190Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn195 200 205Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe210 215 220Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu225 230 235 240Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly245 250 255Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala Leu260 265 270<210>45<211>546<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(546)
<400>45ttg ctt tct cat ttg gat atg aaa ttc gtc agc gac ctt ttg tct gtc48Leu Leu Ser His Leu Asp Met Lys Phe Val Ser Asp Leu Leu Ser Val1 5 10 15atc ttg ttt ttt gct act tat acc gtt acc aaa aat atg att gcc gct96Ile Leu Phe Phe Ala Thr Tyr Thr Val Thr Lys Asn Met Ile Ala Ala20 25 30acg gcg gtt gcc ttg gtt gcc ggt gtg gtt cag gcg gct ttt ctg tat144Thr Ala Val Ala Leu Val Ala Gly Val Val Gln Ala Ala Phe Leu Tyr35 40 45tgg aaa tat aaa aag ctg gat acg atg cag tgg gtc gga ctg gtg ctg192Trp Lys Tyr Lys Lys Leu Asp Thr Met Gln Trp Val Gly Leu Val Leu50 55 60att gtc gta ttc ggc ggc gca acc att gtt ttg ggc gac agc cgc ttc240Ile Val Val Phe Gly Gly Ala Thr Ile Val Leu Gly Asp Ser Arg Phe65 70 75 80att atg tgg aag ccg agc gtt ttg ttt tgg ctg ggc gcg ctg ttc ctg288Ile Met Trp Lys Pro Ser Val Leu Phe Trp Leu Gly Ala Leu Phe Leu85 90 95tgg ggc agc cac ctc gcc ggt aaa aac ggc ttg aag gcg agt atc ggc336Trp Gly Ser His Leu Ala Gly Lys Asn Gly Leu Lys Ala Ser Ile Gly100 105 110agg gag att cag ctt ccg gat gcc gta tgg gcg aaa ttg acg tat atg384Arg Glu Ile Gln Leu Pro Asp Ala Val Trp Ala Lys Leu Thr Tyr Met115 120 125tgg gtc ggt ttc ctg att ttt atg ggt atc gcc aac tgg ttt gtg ttt432Trp Val Gly Phe Leu Ile Phe Met Gly Ile Ala Asn Trp Phe Val Phe130 135 140acc cgg ttc gag tcg caa tgg gtc aac tat aaa atg ttc ggc tcg act480Thr Arg Phe Glu Ser Gln Trp Val Asn Tyr Lys Met Phe Gly Ser Thr145 150 155 160gca ctg atg ctt gtt ttc ttt att att cag ggt att tat ctg agt acc528Ala Leu Met Leu Val Phe Phe Ile Ile Gln Gly Ile Tyr Leu Ser Thr165 170 175tgt ctg aaa aag gag gat546Cys Leu Lys Lys Glu Asp180
<210>46<211>182<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>46Leu Leu Ser His Leu Asp Met Lys Phe Val Ser Asp Leu Leu Ser Val1 5 10 15Ile Leu Phe Phe Ala Thr Tyr Thr Val Thr Lys Asn Met Ile Ala Ala20 25 30Thr Ala Val Ala Leu Val Ala Gly Val Val Gln Ala Ala Phe Leu Tyr35 40 45Trp Lys Tyr Lys Lys Leu Asp Thr Met Gln Trp Val Gly Leu Val Leu50 55 60Ile Val Val Phe Gly Gly Ala Thr Ile Val Leu Gly Asp Ser Arg Phe65 70 75 80Ile Met Trp Lys Pro Ser Val Leu Phe Trp Leu Gly Ala Leu Phe Leu85 90 95Trp Gly Ser His Leu Ala Gly Lys Asn Gly Leu Lys Ala Ser Ile Gly100 105 110Arg Glu Ile Gln Leu Pro Asp Ala Val Trp Ala Lys Leu Thr Tyr Met115 120 125Trp Val Gly Phe Leu Ile Phe Met Gly Ile Ala Asn Trp Phe Val Phe130 135 140Thr Arg Phe Glu Ser Gln Trp Val Asn Tyr Lys Met Phe Gly Ser Thr145 150 155 160Ala Leu Met Leu Val Phe Phe Ile Ile Gln Gly Ile Tyr Leu Ser Thr165 170 175Cys Leu Lys Lys Glu Asp180<210>47<211>585
<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(585)<400>47ttg aat att aaa ctg aaa acc ttg tta ttg ccc ttc gcc acg ctg gca48Leu Asn Ile Lys Leu Lys Thr Leu Leu Leu Pro Phe Ala Thr Leu Ala1 5 10 15ttg tgc acc aat gct ttt gcc gcc ccg ccc agc gac gcg tcg ttg gcg96Leu Cys Thr Asn Ala Phe Ala Ala Pro Pro Ser Asp Ala Ser Leu Ala20 25 30cgt tgg ctg gat acg cag aat ttt gac cgg gat ata gaa aaa aat atg144Arg Trp Leu Asp Thr Gln Asn Phe Asp Arg Asp Ile Glu Lys Asn Met35 40 45att gag ggc ttt aat gcc gga ttt aaa ccg tat gcg gac aaa gcc ctt192Ile Glu Gly Phe Asn Ala Gly Phe Lys Pro Tyr Ala Asp Lys Ala Leu50 55 60gcc gaa atg ccg gaa gcg aaa aaa gat cag gcg gca gaa gcc ttt aac240Ala Glu Met Pro Glu Ala Lys Lys Asp Gln Ala Ala Glu Ala Phe Asn65 70 75 80cgt tat cgt gag aat gtt ttg aaa gat ttg att acg ccc gaa gtg aaa288Arg Tyr Arg Glu Asn Val Leu Lys Asp Leu Ile Thr Pro Glu Val Lys85 90 95cag gct gtc cgc aat act tta ttg aag aat gcc cgt gag ata tac acg336Gln Ala Val Arg Asn Thr Leu Leu Lys Asn Ala Arg Glu Ile Tyr Thr100 105 110caa gaa gaa att gac ggc atg att gcc ttt tac ggt tcg cct gtc ggt384Gln Glu Glu Ile Asp Gly Met Ile Ala Phe Tyr Gly Ser Pro Val Gly115 120 125cag tcc gtc gtt gcc aaa aat ccg cgc tta atc aag aaa tcg atg agt432Gln Ser Val Val Ala Lys Asn Pro Arg Leu Ile Lys Lys Ser Met Ser130 135 140gaa ata gcg gta tct tgg act gca ttg tca ggg aaa atc gcg caa cat480Glu Ile Ala Val Ser Trp Thr Ala Leu Ser Gly Lys Ile Ala Gln His145 150 155 160
cat ctg ccc gag ttt acg gaa gag ttg cgg cgc atc atc tgc ggc ggt528His Leu Pro Glu Phe Thr Glu Glu Leu Arg Arg Ile Ile Cys Gly Gly165 170 175aaa aat ccc gat gcg ggc tgt aaa caa gcc gga cag gtt ggg aaa agg576Lys Asn Pro Asp Ala Gly Cys Lys Gln Ala Gly Gln Val Gly Lys Arg180 185 190cat cag aaa585His Gln Lys195<210>48<211>195<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>48Leu Asn Ile Lys Leu Lys Thr Leu Leu Leu Pro Phe Ala Thr Leu Ala1 5 10 15Leu Cys Thr Asn Ala Phe Ala Ala Pro Pro Ser Asp Ala Ser Leu Ala20 25 30Arg Trp Leu Asp Thr Gln Asn Phe Asp Arg Asp Ile Glu Lys Asn Met35 40 45Ile Glu Gly Phe Asn Ala Gly Phe Lys Pro Tyr Ala Asp Lys Ala Leu50 55 60Ala Glu Met Pro Glu Ala Lys Lys Asp Gln Ala Ala Glu Ala Phe Asn65 70 75 80Arg Tyr Arg Glu Asn Val Leu Lys Asp Leu Ile Thr Pro Glu Val Lys85 90 95Gln Ala Val Arg Asn Thr Leu Leu Lys Asn Ala Arg Glu Ile Tyr Thr100 105 110Gln Glu Glu Ile Asp Gly Met Ile Ala Phe Tyr Gly Ser Pro Val Gly115 120 125Gln Ser Val Val Ala Lys Asn Pro Arg Leu Ile Lys Lys Ser Met Ser130 135 140Glu Ile Ala Val Ser Trp Thr Ala Leu Ser Gly Lys Ile Ala Gln His145 150 155 160
His Leu Pro Glu Phe Thr Glu Glu Leu Arg Arg Ile Ile Cys Gly Gly165 170 175Lys Asn Pro Asp Ala Gly Cys Lys Gln Ala Gly Gln Val Gly Lys Arg180 185 190His Gln Lys195<210>49<211>462<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(462)<400>49ttg ctt tgc ccg gaa aaa atg tcg ggg atg gcg gga cag tat ccg tac48Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr1 5 10 15ggc gtc cgg tcg ggt ttg cgg agg aac ggc ttg aaa ctt tgg gat att96Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile20 25 30cat ttt aga atg acc cgt ttt atc gtc gca aga tgc ggt tta ttg ttt144His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe35 40 45gca acc ctt aaa gga aaa acc atg aag aaa atg ttc gtg ctg ttc tgt192Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys50 55 60atg ctg ttc tcc tgc gcc ttc tcc ctt gcg gcg gta aac atc aat gcg240Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala65 70 75 80gct tcg cag cag gag ctg gag gcg ctg ccg ggc ata ggc cct gcg aag288Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys85 90 95gcg aag gcc att gcg gaa tac cgt gcg caa aac ggt gcg ttc aag tct336Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser
100 105 110gta gac gat ttg acc aag gta aag ggc atc ggc cct gcg gtg ctg gcg384Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala115 120 125aag ctg aag gat cag gct tct gtc ggt gcg ccc gca cca aaa ggc cca432Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro130 135 140gct aaa cca gtg ctg ccc gcg gat aaa aaa462Ala Lys Pro Val Leu Pro Ala Asp Lys Lys145 150<210>50<211>154<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>50Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr1 5 10 15Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile20 25 30His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe35 40 45Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys50 55 60Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala65 70 75 80Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys85 90 95Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser100 105 110Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala115 120 125Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro130 135 140
Ala Lys Pro Val Leu Pro Ala Asp Lys Lys145 150<210>51<211>969<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(969)<400>51atg tcc gcc aag ttc caa caa gaa acc ctc aaa tcc cgt ttc gcg caa48Met Ser Ala Lys Phe Gln Gln Glu Thr Leu Lys Ser Arg Phe Ala Gln1 5 10 15gcc aaa gtc ctg gtt gtc ggc gac gtg atg ctc gac cgc tat tgg ttc96Ala Lys Val Leu Val Val Gly Asp Val Met Leu Asp Arg Tyr Trp Phe20 25 30ggc gat gtg tcc cgt att tcg ccc gaa gcc ccc gtg ccg gtg gcg aaa144Gly Asp Val Ser Arg Ile Ser Pro Glu Ala Pro Val Pro Val Ala Lys35 40 45atc gga cga atc gac caa cgc gcg ggc gga gcg gca aat gtc gcg cgc192Ile Gly Arg Ile Asp Gln Arg Ala Gly Gly Ala Ala Asn Val Ala Arg50 55 60aac atc gct tcg ctg ggc ggc aaa gta ggg ctg ttg tcg gta acc ggt240Asn Ile Ala Ser Leu Gly Gly Lys Val Gly Leu Leu Ser Val Thr Gly65 70 75 80aac gac gaa gcc gcc gac gcg ctc gac gcg ctg atg gtg cag gac ggc288Asn Asp Glu Ala Ala Asp Ala Leu Asp Ala Leu Met Val Gln Asp Gly85 90 95gtc gcc tcc tat ctg atg cgc gac aaa caa atc gcc acc acc gtc aaa336Val Ala Ser Tyr Leu Met Arg Asp Lys Gln Ile Ala Thr Thr Val Lys100 105 110ctg cgc gtc gtc gcc cgc aac cag cag ctt atc cgc ctt gat ttt gaa384Leu Arg Val Val Ala Arg Asn Gln Gln Leu Ile Arg Leu Asp Phe Glu115 120 125gaa cat ccc aac cgc gaa gtg ttg gaa caa atc aag cgg aaa tac cgc432
Glu His Pro Asn Arg Glu Val Leu Glu Gln Ile Lys Arg Lys Tyr Arg130 135 140gaa atc ttg ccc gaa tac gac gca atc att ttt tca gac tac ggc aaa480Glu Ile Leu Pro Glu Tyr Asp Ala Ile Ile Phe Ser Asp Tyr Gly Lys145 150 155 160ggc ggc ctg tcg cac atc tcc gat atg atc gat tgg gcg aaa cac gaa528Gly Gly Leu Ser His Ile Ser Asp Met Ile Asp Trp Ala Lys His Glu165 170 175ggc aaa acc gta tta atc gac ccc aaa ggc gac gat tac gaa aaa tac576Gly Lys Thr Val Leu Ile Asp Pro Lys Gly Asp Asp Tyr Glu Lys Tyr180 185 190gcc ggc gca acc ctg att acg ccc aac cgc gcc gaa ttg aaa gaa gtg624Ala Gly Ala Thr Leu Ile Thr Pro Asn Arg Ala Glu Leu Lys Glu Val195 200 205gtc ggc agc tgg aaa aac gaa aat gat ttg acc gaa aaa gcc caa aac672Val Gly Ser Trp Lys Asn Glu Asn Asp Leu Thr Glu Lys Ala Gln Asn210 215 220ctg cgc cgc cac ctc gac ttg acc gct att tta ctg acc cga agc gaa720Leu Arg Arg His Leu Asp Leu Thr Ala Ile Leu Leu Thr Arg Ser Glu225 230 235 240gaa ggc atg acc ttg ttc agc gaa ggc gaa ccc att tac cag ccc acc768Glu Gly Met Thr Leu Phe Ser Glu Gly Glu Pro Ile Tyr Gln Pro Thr245 250 255cgc gcc caa gaa gtt tac gac gta tcc ggt gcg ggc gac acc gtc att816Arg Ala Gln Glu Val Tyr Asp Val Ser Gly Ala Gly Asp Thr Val Ile260 265 270gcc gga atg ggc ttg ggt ttg gcg gca ggc tgc acc atg ccc gaa gcc864Ala Gly Met Gly Leu Gly Leu Ala Ala Gly Cys Thr Met Pro Glu Ala275 280 285atg tac ctt gcc aat act gcg gcc ggg gtt gtc gtg gcg aaa ctc ggt912Met Tyr Leu Ala Asn Thr Ala Ala Gly Val Val Val Ala Lys Leu Gly290 295 300acg gcg gtt tgc tcg ttt gcc gaa ttg acc aag gca ttg tca ggg caa960Thr Ala Val Cys Ser Phe Ala Glu Leu Thr Lys Ala Leu Ser Gly Gln305 310 315 320tca aca atg969
Ser Thr Met<210>52<211>323<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>52Met Ser Ala Lys Phe Gln Gln Glu Thr Leu Lys Ser Arg Phe Ala Gln1 5 10 15Ala Lys Val Leu Val Val Gly Asp Val Met Leu Asp Arg Tyr Trp Phe20 25 30Gly Asp Val Ser Arg Ile Ser Pro Glu Ala Pro Val Pro Val Ala Lys35 40 45Ile Gly Arg Ile Asp Gln Arg Ala Gly Gly Ala Ala Asn Val Ala Arg50 55 60Asn Ile Ala Ser Leu Gly Gly Lys Val Gly Leu Leu Ser Val Thr Gly65 70 75 80Asn Asp Glu Ala Ala Asp Ala Leu Asp Ala Leu Met Val Gln Asp Gly85 90 95Val Ala Ser Tyr Leu Met Arg Asp Lys Gln Ile Ala Thr Thr Val Lys100 105 110Leu Arg Val Val Ala Arg Asn Gln Gln Leu Ile Arg Leu Asp Phe Glu115 120 125Glu His Pro Asn Arg Glu Val Leu Glu Gln Ile Lys Arg Lys Tyr Arg130 135 140Glu Ile Leu Pro Glu Tyr Asp Ala Ile Ile Phe Ser Asp Tyr Gly Lys145 150 155 160Gly Gly Leu Ser His Ile Ser Asp Met Ile Asp Trp Ala Lys His Glu165 170 175Gly Lys Thr Val Leu Ile Asp Pro Lys Gly Asp Asp Tyr Glu Lys Tyr180 185 190Ala Gly Ala Thr Leu Ile Thr Pro Asn Arg Ala Glu Leu Lys Glu Val195 200 205
Val Gly Ser Trp Lys Asn Glu Asn Asp Leu Thr Glu Lys Ala Gln Asn210 215 220Leu Arg Arg His Leu Asp Leu Thr Ala Ile Leu Leu Thr Arg Ser Glu225 230 235 240Glu Gly Met Thr Leu Phe Ser Glu Gly Glu Pro Ile Tyr Gln Pro Thr245 250 255Arg Ala Gln Glu Val Tyr Asp Val Ser Gly Ala Gly Asp Thr Val Ile260 265 270Ala Gly Met Gly Leu Gly Leu Ala Ala Gly Cys Thr Met Pro Glu Ala275 280 285Met Tyr Leu Ala Asn Thr Ala Ala Gly Val Val Val Ala Lys Leu Gly290 295 300Thr Ala Val Cys Ser Phe Ala Glu Leu Thr Lys Ala Leu Ser Gly Gln305 310 315 320Ser Thr Met<210>53<211>864<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(864)<400>53atg aaa gca aaa atc ctg act tcc gtt gca ctg ctt gcc tgt tcc ggc48Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly1 5 10 15agc ctg ttt gcc caa acg ctg gca acc gtc aac ggt cag aaa atc gac96Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp20 25 30agt tcc gtc att gat gcg cag gtt gcc gca ttc cgt gcg gaa aac agc144Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser35 40 45
cgt gcc gaa gac acg ccg caa ctg cgc caa tcc ctg ctg gaa aac gaa192Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu50 55 60gtg gtc aac acc gtg gtc gca cag gaa gtg aaa cgc ctg aaa ctc gac240Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp65 70 75 80cgg tcg gca gag ttt aaa aat gcg ctt gcc aaa ttg cgt gcc gaa gcg288Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala85 90 95aaa aag tcg ggc gac gac aag aaa ccg tcc ttc aaa acc gtt tgg cag336Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln100 105 110gcg gta aaa tat ggc ttg aac ggc gag gca tac gcg ctg cat atc gcc384Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala115 120 125aaa acc caa ccg gtt tcc gag cag gaa gta aaa gcc gca tat gac aat432Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn130 135 140atc agc ggt ttt tac aaa ggt acg cag gaa gtc cag ttg ggc gaa atc480Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile145 150 155 160ctg acc gac aag gaa gaa aat gca aaa aaa gcg gtt gcc gac ttg aag528Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys165 170 175gcg aaa aaa ggt ttc gat gcc gtc ttg aaa caa tat tcc ctc aac gac576Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp180 185 190cgt acc aaa cag acc ggt gcg ccg gtc gga tat gtg ccg ctg aaa gat624Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp195 200 205ttg gaa cag ggt gtt ccg ccg ctt tat cag gca att aag gac ttg aaa672Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys210 215 220aaa ggc gaa ttt acg gca acg ccg ctg aaa aac ggc gat ttc tac ggc720Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly225 230 235 240
gtt tat tat gtc aac gac agc cgc gag gta aaa gtg cct tct ttt gat 768Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp245 250 255gaa atg aaa gga cag att gcg ggc aac ctt cag gcg gaa cgg att gac 816Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp260 265 270cgt gcc gtc ggt gca ctg ttg ggc aag gca aac atc aaa cct gca aaa 864Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys275 280 285<210>54<211>288<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>54Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly1 5 10 15Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp20 25 30Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser35 40 45Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu50 55 60Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp65 70 75 80Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala85 90 95Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln100 105 110Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala115 120 125Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn130 135 140Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile145 150 155 160
Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys165 170 175Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp180 185 190Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp195 200 205Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys210 215 220Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly225 230 235 240Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp245 250 255Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp260 265 270Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys275 280 285<210>55<211>1257<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1257)<400>55atg aaa cag acc gtc ctc aaa aat aac ctg caa aac ctg ctt gaa agc48Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser1 5 10 15gca gaa aat atc ctg ctg ctt caa ggc cct gtc ggc gat ttt ttt ctg96Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu20 25 30cgc ctt gcc gac tgg ctg act gca aac ggc aaa acc gta cat aaa ttc144Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe35 40 45
aac ttt aat gca ggc gac gac tat ttt tat ccg ccc act caa gcg cat192Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His50 55 60acc gtt gtt ttt aac gac aac tac gat gcc ttt cct gag ttt ttg caa240Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln65 70 75 80gaa tac atc act caa cat cac atc cag gcc gtt gtc tgc ttt ggc gac288Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp85 90 95aca cgc cct tat cac gtc att gca aaa cgc att gca aac gaa aac caa336Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln100 105 110gcc agt ttc tgg gcg ttt gaa gaa ggc tat ttc cgc ccc tac tac atc384Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile115 120 125acc tta gaa aaa gac ggc gtc aac gca ttt tcc ccg ttg ccg cgc cgt432Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg130 135 140gcc gac ttt ttt ctt gaa caa ttc cct aag ctt gcc cag caa gaa tat480Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr145 150 155 160aaa gcg cca acg ccg gta cac ggc ggt ttt acg ccc atg gca aaa aac528Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn165 170 175gct atc cgt tac tat atc gag ttg ttc cgc aat cta cgc aaa tac ccc576Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Asn Leu Arg Lys Tyr Pro180 185 190gac tac atc cac cac cgc gca ccc aat gcc ggc cat tac ctc aaa ccg624Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro195 200 205tgg tcg ctc tcc atc ctc aag cgt ttg aac tac tat att gaa gac atc672Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile210 215 220caa atc gcc aaa cgt gtg gaa gca ggc aaa tac ggc aag ttt ttt att720Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile225 230 235 240
gtt ccc ttg cag gta ttc aac gac agc caa gtc cgt atc cat tgc gac768Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp245 250 255ttt ccc agc gtc cgc agc ttc ctg ctc cat gtt ttg agt tca ttt gcc816Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala260 265 270gaa cac gcg cct gcc gat acc aac atc atc atc aag cat cat cct atg864Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met275 280 285gac cgc ggc ttt atc gac tac tgg cgc gac att aaa cgc ttt atc aaa912Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys290 295 300gaa cac ccc gaa ctc aaa ggc cgt gtg att tat gtc cat gat gtc ccc960Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro305 310 315 320ctg ccc gtt ttc ctg cgc cac ggt ctc ggc atg gtt acc atc aac agc1008Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser325 330 335acc agc ggc ctg tcc gga ctg att cac aat atg cca gtt aag gtt ctc1056Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu340 345 350ggc cgt gcc tat tat gat att ccc ggc att act gac caa aat acc ttg1104Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu355 360 365gca gaa ttt tgg aat cat ccg aca ccg cct gac aaa gag ctg ttc cat1152Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His370 375 380gcc tac cga atg tac cac ctc aac gtg acc caa att aac ggc aac ttc1200Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe385 390 395 400tac agt cag gtc ttt ttt cct aac aaa aac aca tcc gac tct tcc aca1248Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr405 410 415cca aca acc1257Pro Thr Thr
<210>56<211>419<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>56Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser1 5 10 15Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu20 25 30Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe35 40 45Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His50 55 60Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln65 70 75 80Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp85 90 95Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln100 105 110Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile115 120 125Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg130 135 140Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr145 150 155 160Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn165 170 175Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Asn Leu Arg Lys Tyr Pro180 185 190Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro195 200 205Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile210 215 220
Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile225 230 235 240Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp245 250 255Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala260 265 270Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met275 280 285Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys290 295 300Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro305 310 315 320Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser325 330 335Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu340 345 350Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu355 360 365Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His370 375 380Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe385 390 395 400Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr405 410 415Pro Thr Thr<210>57<211>1407<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1407)<400>57atg acc tcc aca ttc ccc cgc cgc ctc gcc cgc aaa atc cgc caa acc48Met Thr Ser Thr Phe Pro Arg Arg Leu Ala Arg Lys Ile Arg Gln Thr1 5 10 15cgc cgc ctg tcg cgc aaa agc atc gcc ttt ctg ttc ctt ttg gca ggt96Arg Arg Leu Ser Arg Lys Ser Ile Ala Phe Leu Phe Leu Leu Ala Gly20 25 30tcg gca ctc gtc gcc ctg acc gcg ctg ttt ttt gcc cat ctt gcc gat144Ser Ala Leu Val Ala Leu Thr Ala Leu Phe Phe Ala His Leu Ala Asp35 40 45ttt gcg ctg gaa ctg aac gcc aaa ctg gtt caa caa tac ccg tgg ttc192Phe Ala Leu Glu Leu Asn Ala Lys Leu Val Gln Gln Tyr Pro Trp Phe50 55 60gcg tgg gtc gcg ctt cct ttg ggt tta ccg ctt att gcg tgg ctc aca240Ala Trp Val Ala Leu Pro Leu Gly Leu Pro Leu Ile Ala Trp Leu Thr65 70 75 80cgc aaa ttc gcc ccc ttc acc gcc ggc agc ggc atc ccg cag gtc atc288Arg Lys Phe Ala Pro Phe Thr Ala Gly Ser Gly Ile Pro Gln Val Ile85 90 95gcc tca ctg tcg ctg ccc tac ggc gca cag aaa acg cgg ctg atc cgc336Ala Ser Leu Ser Leu Pro Tyr Gly Ala Gln Lys Thr Arg Leu Ile Arg100 105 110ctc ggg cag acg ctg ctg aag att ccg cta acc ttt ttg ggt atg ctg384Leu Gly Gln Thr Leu Leu Lys Ile Pro Leu Thr Phe Leu Gly Met Leu115 120 125ttc ggc gcg tcc atc gga cgc gaa ggt ccg tcc gtg cag gtc ggc gcg432Phe Gly Ala Ser Ile Gly Arg Glu Gly Pro Ser Val Gln Val Gly Ala130 135 140gca gtg atg ggc gcg tgg ggc gcg tgg tgc aag aaa cac ggc ttg gca480Ala Val Met Gly Ala Trp Gly Ala Trp Cys Lys Lys His Gly Leu Ala145 150 155 160ttc aaa ggg atg cag gaa aac gat ttg atg gcg gcg ggc gcg gcg ggc528Phe Lys Gly Met Gln Glu Asn Asp Leu Met Ala Ala Gly Ala Ala Gly165 170 175
ggt ttg gca gcc gcg ttc aac gcg ccg ctg gcg ggc gtg att ttc gcc576Gly Leu Ala Ala Ala Phe Asn Ala Pro Leu Ala Gly Val Ile Phe Ala180 185 190att gag gaa ctc ggg cgc ggc atc atg ttg cgc tgg gag agg caa att624Ile Glu Glu Leu Gly Arg Gly Ile Met Leu Arg Trp Glu Arg Gln Ile195 200 205ctt ttg ggc gtg ctc gcc tcc ggt ttc ata cag gtc gcc att cag ggc672Leu Leu Gly Val Leu Ala Ser Gly Phe Ile Gln Val Ala Ile Gln Gly210 215 220aac aac ccg tat ttt tcc ggc ttc aac ggc ggc gta ttg gaa cat atc720Asn Asn Pro Tyr Phe Ser Gly Phe Asn Gly Gly Val Leu Glu His Ile225 230 235 240ttt ctg tgg gtc gca ctg tcc ggc ctg gtt tgc ggc gcg gcg ggc ggg768Phe Leu Trp Val Ala Leu Ser Gly Leu Val Cys Gly Ala Ala Gly Gly245 250 255ctg ttc gga cgt ttg ctc tat cgc ggt gcg gcg gcg ttt gca ccg cgc816Leu Phe Gly Arg Leu Leu Tyr Arg Gly Ala Ala Ala Phe Ala Pro Arg260 265 270aag ata cgc ggc ttc atc cgc aac cgt ccg ctg ctg ctg gcg gca ctg864Lys Ile Arg Gly Phe Ile Arg Asn Arg Pro Leu Leu Leu Ala Ala Leu275 280 285atg ggg ctg ctg ctc gcc ctg ctc ggc acg ttc tac caa ggc aaa acc912Met Gly Leu Leu Leu Ala Leu Leu Gly Thr Phe Tyr Gln Gly Lys Thr290 295 300tac ggc acc ggc tac cac gaa gcc gcc caa gcc ctg cac ggc atc tac960Tyr Gly Thr Gly Tyr His Glu Ala Ala Gln Ala Leu His Gly Ile Tyr305 310 315 320gaa gcc ccc ttc gga ctc gcc gcc gcc aaa tgg ctc gcc acc gta ttc1008Glu Ala Pro Phe Gly Leu Ala Ala Ala Lys Trp Leu Ala Thr Val Phe325 330 335agc tat tgg gca ggc gtt ccg ggc ggc att ttc act ccc tcg ctg acc1056Ser Tyr Trp Ala Gly Val Pro Gly Gly Ile Phe Thr Pro Ser Leu Thr340 345 350ata ggc gcg gtt ttg ggc gag cat atc gcc gcc atc gcc gac ata tcg1104Ile Gly Ala Val Leu Gly Glu His Ile Ala Ala Ile Ala Asp Ile Ser355 360 365
cag ggt gca aac atc atc gtc ctc atc tgc atg gcg gca ttt ctg gcg1152Gln Gly Ala Asn Ile Ile Val Leu Ile Cys Met Ala Ala Phe Leu Ala370 375 380ggc gcg aca caa tcc ccg att act tcc gcc gtc gtc gtc atg gaa atg1200Gly Ala Thr Gln Ser Pro Ile Thr Ser Ala Val Val Val Met Glu Met385 390 395 400acg ggc gga caa agc ctg ctg ttt tgg atg ctg att gcc tgc att ttc1248Thr Gly Gly Gln Ser Leu Leu Phe Trp Met Leu Ile Ala Cys Ile Phe405 410 415gcc tcg cag gtt tcg cgc cag ttt tcg ccg cgt ccg ttc tac cac gca1296Ala Ser Gln Val Ser Arg Gln Phe Ser Pro Arg Pro Phe Tyr His Ala420 425 430tcg gga atg cgc ttc cgc cag cgc gtg ctt caa gaa acc gcc gcc caa1344Ser Gly Met Arg Phe Arg Gln Arg Val Leu Gln Glu Thr Ala Ala Gln435 440 445acc ggc aat gcg ccc gca aga ccg caa aca gca aac agc aaa acg gga1392Thr Gly Asn Ala Pro Ala Arg Pro Gln Thr Ala Asn Ser Lys Thr Gly450 455 460atg ccg tct gaa aat1407Met Pro Ser Glu Asn465<210>58<211>469<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>58Met Thr Ser Thr Phe Pro Arg Arg Leu Ala Arg Lys Ile Arg Gln Thr1 5 10 15Arg Arg Leu Ser Arg Lys Ser Ile Ala Phe Leu Phe Leu Leu Ala Gly20 25 30Ser Ala Leu Val Ala Leu Thr Ala Leu Phe Phe Ala His Leu Ala Asp35 40 45Phe Ala Leu Glu Leu Asn Ala Lys Leu Val Gln Gln Tyr Pro Trp Phe50 55 60Ala Trp Val Ala Leu Pro Leu Gly Leu Pro Leu Ile Ala Trp Leu Thr
65 70 75 80Arg Lys Phe Ala Pro Phe Thr Ala Gly Ser Gly Ile Pro Gln Val Ile85 90 95Ala Ser Leu Ser Leu Pro Tyr Gly Ala Gln Lys Thr Arg Leu Ile Arg100 105 110Leu Gly Gln Thr Leu Leu Lys Ile Pro Leu Thr Phe Leu Gly Met Leu115 120 125Phe Gly Ala Ser Ile Gly Arg Glu Gly Pro Ser Val Gln Val Gly Ala130 135 140Ala Val Met Gly Ala Trp Gly Ala Trp Cys Lys Lys His Gly Leu Ala145 150 155 160Phe Lys Gly Met Gln Glu Asn Asp Leu Met Ala Ala Gly Ala Ala Gly165 170 175Gly Leu Ala Ala Ala Phe Asn Ala Pro Leu Ala Gly Val Ile Phe Ala180 185 190Ile Glu Glu Leu Gly Arg Gly Ile Met Leu Arg Trp Glu Arg Gln Ile195 200 205Leu Leu Gly Val Leu Ala Ser Gly Phe Ile Gln Val Ala Ile Gln Gly210 215 220Asn Asn Pro Tyr Phe Ser Gly Phe Asn Gly Gly Val Leu Glu His Ile225 230 235 240Phe Leu Trp Val Ala Leu Ser Gly Leu Val Cys Gly Ala Ala Gly Gly245 250 255Leu Phe Gly Arg Leu Leu Tyr Arg Gly Ala Ala Ala Phe Ala Pro Arg260 265 270Lys Ile Arg Gly Phe Ile Arg Asn Arg Pro Leu Leu Leu Ala Ala Leu275 280 285Met Gly Leu Leu Leu Ala Leu Leu Gly Thr Phe Tyr Gln Gly Lys Thr290 295 300Tyr Gly Thr Gly Tyr His Glu Ala Ala Gln Ala Leu His Gly Ile Tyr305 310 315 320Glu Ala Pro Phe Gly Leu Ala Ala Ala Lys Trp Leu Ala Thr Val Phe
325 330 335Ser Tyr Trp Ala Gly Val Pro Gly Gly Ile Phe Thr Pro Ser Leu Thr340 345 350Ile Gly Ala Val Leu Gly Glu His Ile Ala Ala Ile Ala Asp Ile Ser355 360 365Gln Gly Ala Asn Ile Ile Val Leu Ile Cys Met Ala Ala Phe Leu Ala370 375 380Gly Ala Thr Gln Ser Pro Ile Thr Ser Ala Val Val Val Met Glu Met385 390 395 400Thr Gly Gly Gln Ser Leu Leu Phe Trp Met Leu Ile Ala Cys Ile Phe405 410 415Ala Ser Gln Val Ser Arg Gln Phe Ser Pro Arg Pro Phe Tyr His Ala420 425 430Ser Gly Met Arg Phe Arg Gln Arg Val Leu Gln Glu Thr Ala Ala Gln435 440 445Thr Gly Asn Ala Pro Ala Arg Pro Gln Thr Ala Asn Ser Lys Thr Gly450 455 460Met Pro Ser Glu Asn465<210>59<211>423<212>DMA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(423)<400>59atg aca caa gaa acc gct ttg ggc gca gca ctg aaa tcc gcc gtc caa48Met Thr Gln Glu Thr Ala Leu Gly Ala Ala Leu Lys Ser Ala Val Gln1 5 10 15act atg agc aaa aag aaa cag aca gaa atg att gcc gac cac atc tac96Thr Met Ser Lys Lys Lys Gln Thr Glu Met Ile Ala Asp His Ile Tyr20 25 30
ggc aaa tat gat gta ttc aaa cga ttt aaa ccg ttg gca ctc ggt atc144Gly Lys Tyr Asp Val Phe Lys Arg Phe Lys Pro Leu Ala Leu Gly Ile35 40 45gat cag gat ttg att gcc gct ttg ccc caa tac gat gcc gca ctg att192Asp Gln Asp Leu Ile Ala Ala Leu Pro Gln Tyr Asp Ala Ala Leu Ile50 55 60gca cgc gtc ctc gcc aac cac tgc cgc cgt ccg cgc tat ctg aaa gcc240Ala Arg Val Leu Ala Asn His Cys Arg Arg Pro Arg Tyr Leu Lys Ala65 70 75 80ttg gcg cgc ggt ggc aaa cgt ttc gat ttg aac aac cgt ttc aaa ggc288Leu Ala Arg Gly Gly Lys Arg Phe Asp Leu Asn Asn Arg Phe Lys Gly85 90 95gaa gtt acc ccc gaa gaa cag gca atc gcg caa aac cat cct ttc gtg336Glu Val Thr Pro Glu Glu Gln Ala Ile Ala Gln Asn His Pro Phe Val100 105 110cag cag gct ttg caa cag cag tcc gcc caa gct gtc gcc gaa acg ccg384Gln Gln Ala Leu Gln Gln Gln Ser Ala Gln Ala Val Ala Glu Thr Pro115 120 125tct gtt gaa gcc gaa gca gcc gaa tct tcc aca aca gaa423Ser Val Glu Ala Glu Ala Ala Glu Ser Ser Thr Thr Glu130 135 140<210>60<211>141<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>60Met Thr Gln Glu Thr Ala Leu Gly Ala Ala Leu Lys Ser Ala Val Gln1 5 10 15Thr Met Ser Lys Lys Lys Gln Thr Glu Met Ile Ala Asp His Ile Tyr20 25 30Gly Lys Tyr Asp Val Phe Lys Arg Phe Lys Pro Leu Ala Leu Gly Ile35 40 45Asp Gln Asp Leu Ile Ala Ala Leu Pro Gln Tyr Asp Ala Ala Leu Ile50 55 60
Ala Arg Val Leu Ala Asn His Cys Arg Arg Pro Arg Tyr Leu Lys Ala65 70 75 80Leu Ala Arg Gly Gly Lys Arg Phe Asp Leu Asn Asn Arg Phe Lys Gly85 90 95Glu Val Thr Pro Glu Glu Gln Ala Ile Ala Gln Asn His Pro Phe Val100 105 110Gln Gln Ala Leu Gln Gln Gln Ser Ala Gln Ala Val Ala Glu Thr Pro115 120 125Ser Val Glu Ala Glu Ala Ala Glu Ser Ser Thr Thr Glu130 135 140<210>61<211>1377<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1377)<400>61atg ttc gct ttc aaa tcc tta ctc gat atg ccg cgc ggt gag gca ctt48Met Phe Ala Phe Lys Ser Leu Leu Asp Met Pro Arg Gly Glu Ala Leu1 5 10 15gcc gtc gtc gtc gct ctg att gcc gcg atg ggc tat acc atc att tca96Ala Val Val Val Ala Leu Ile Ala Ala Met Gly Tyr Thr Ile Ile Ser20 25 30ttg gag tgg ctg ccg cat atg tcc att att gcc gcc atc gtc gtg ctg144Leu Glu Trp Leu Pro His Met Ser Ile Ile Ala Ala Ile Val Val Leu35 40 45att ttg tac ggc ttg gcg cgc ggt ttg aaa tac aac gat atg cag cag192Ile Leu Tyr Gly Leu Ala Arg Gly Leu Lys Tyr Asn Asp Met Gln Gln50 55 60ggc atg ata ggc gcg ttg aat cag ggt atg ggc gcg att tac ctg ttt240Gly Met Ile Gly Ala Leu Asn Gln Gly Met Gly Ala Ile Tyr Leu Phe65 70 75 80ttc ttc atc ggg ctg atg gtc agc gcg ctg atg atg agc ggc gcg att288
Phe Phe Ile Gly Leu Met Val Ser Ala Leu Met Met Ser Gly Ala Ile85 90 95ccg acg ctg atg tat tac ggt ttc gga ctg att tcc ccg act tat ttt336Pro Thr Leu Met Tyr Tyr Gly Phe Gly Leu Ile Ser Pro Thr Tyr Phe100 105 110tat ttt tcc gcc ttc gcg ctg tgt tcc gtc atc ggc gtg tcc atc ggc384Tyr Phe Ser Ala Phe Ala Leu Cys Ser Val Ile Gly Val Ser Ile Gly115 120 125agc agc ctg acc acc tgc gcc act gtc ggc gtt gcc ttt atg ggt atg432Ser Ser Leu Thr Thr Cys Ala Thr Val Gly Val Ala Phe Met Gly Met130 135 140gcg gcg gcg ttt cag gcc gat atg gcg atg acg gcg ggc gcg att gtt480Ala Ala Ala Phe Gln Ala Asp Met Ala Met Thr Ala Gly Ala Ile Val145 150 155 160tcg ggc gca ttt ttt ggc gac aaa atg tcc ccg ctt tcc gat acg acg528Ser Gly Ala Phe Phe Gly Asp Lys Met Ser Pro Leu Ser Asp Thr Thr165 170 175ggc att tcc gcg tcc att gtc ggt atc gac ctg ttt gaa cac atc aaa576Gly Ile Ser Ala Ser Ile Val Gly Ile Asp Leu Phe Glu His Ile Lys180 185 190aat atg atg tac acc acc att ccc gcg tgg ctc atc agt gcg gca ctg624Asn Met Met Tyr Thr Thr Ile Pro Ala Trp Leu Ile Ser Ala Ala Leu195 200 205atg ctg tgg ctt ctt ccc agc gtc gcc gcg cag gat ttg aac agc gtc672Met Leu Trp Leu Leu Pro Ser Val Ala Ala Gln Asp Leu Asn Ser Val210 215 220gaa tcc ttc cgc agc cag ctt gaa gcc acg gga ttg gtg cac tgc tat720Glu Ser Phe Arg Ser Gln Leu Glu Ala Thr Gly Leu Val His Cys Tyr225 230 235 240tcg ctg att ccg ttt gcg ctg ttg gtc gtt ttg gca ttg atg cgc gtc768Ser Leu Ile Pro Phe Ala Leu Leu Val Val Leu Ala Leu Met Arg Val245 250 255aat gcc gtg gtc gct atg ctc ttt acc gtc att gcc gcc gtt gcc gta816Asn Ala Val Val Ala Met Leu Phe Thr Val Ile Ala Ala Val Ala Val260 265 270acg tat ctg cac agc acg ccc gat ctg cgt cag ctc ggc gcg tgg ttt864
Thr Tyr Leu His Ser Thr Pro Asp Leu Arg Gln Leu Gly Ala Trp Phe275 280 285tac ggc ggc tac aaa ctc gaa ggc gaa gcg ttt aaa gac att gcc aaa912Tyr Gly Gly Tyr Lys Leu Glu Gly Glu Ala Phe Lys Asp Ile Ala Lys290 295 300ctc att tct cgc ggc ggt ttg gaa agt atg ttt ttc acg cag acc atc960Leu Ile Ser Arg Gly Gly Leu Glu Ser Met Phe Phe Thr Gln Thr Ile305 310 315 320gtg att ctt ggg atg agc ctt ggc ggg ctg ctg ttt gca ctg ggc gcg1008Val Ile Leu Gly Met Ser Leu Gly Gly Leu Leu Phe Ala Leu Gly Ala325 330 335att cct tcc ctg ctg gat gcc gtc cgc agc ttt ttg acg aat gcc ggg1056Ile Pro Ser Leu Leu Asp Ala Val Arg Ser Phe Leu Thr Asn Ala Gly340 345 350cgt gcc aca ttc agc gtt gcc atg act tcg gtc ggg gtt aat ttc ctg1104Arg Ala Thr Phe Ser Val Ala Met Thr Ser Val Gly Val Asn Phe Leu355 360 365atc ggc gag caa tat ttg agt att ttg ttg tcg ggt gaa acg ttc aaa1152Ile Gly Glu Gln Tyr Leu Ser Ile Leu Leu Ser Gly Glu Thr Phe Lys370 375 380cct gtt tac gat aag ctc ggt ctg cat tcg cgc aat ctg tcg cgg acg1200Pro Val Tyr Asp Lys Leu Gly Leu His Ser Arg Asn Leu Ser Arg Thr385 390 395 400ctg gaa gat gcg ggg acg gtc atc aac ccg ctc gta ccg tgg agc gta1248Leu Glu Asp Ala Gly Thr Val Ile Asn Pro Leu Val Pro Trp Ser Val405 410 415tgc ggc gtg ttc atc agc cac gcg ctg ggc gtg ccg gtt tgg gaa tat1296Cys Gly Val Phe Ile Ser His Ala Leu Gly Val Pro Val Trp Glu Tyr420 425 430ctg ccg tat gcc ttt ttc tgc tat ttg agt ttg gct ttg acc ctg tta1344Leu Pro Tyr Ala Phe Phe Cys Tyr Leu Ser Leu Ala Leu Thr Leu Leu435 440 445ttc ggt tgg acg ggg ctg act ttg agc aaa aaa1377Phe Gly Trp Thr Gly Leu Thr Leu Ser Lys Lys450 455
<210>62<211>459<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>62Met Phe Ala Phe Lys Ser Leu Leu Asp Met Pro Arg Gly Glu Ala Leu1 5 10 15Ala Val Val Val Ala Leu Ile Ala Ala Met Gly Tyr Thr Ile Ile Ser20 25 30Leu Glu Trp Leu Pro His Met Ser Ile Ile Ala Ala Ile Val Val Leu35 40 45Ile Leu Tyr Gly Leu Ala Arg Gly Leu Lys Tyr Asn Asp Met Gln Gln50 55 60Gly Met Ile Gly Ala Leu Asn Gln Gly Met Gly Ala Ile Tyr Leu Phe65 70 75 80Phe Phe Ile Gly Leu Met Val Ser Ala Leu Met Met Ser Gly Ala Ile85 90 95Pro Thr Leu Met Tyr Tyr Gly Phe Gly Leu Ile Ser Pro Thr Tyr Phe100 105 110Tyr Phe Ser Ala Phe Ala Leu Cys Ser Val Ile Gly Val Ser Ile Gly115 120 125Ser Ser Leu Thr Thr Cys Ala Thr Val Gly Val Ala Phe Met Gly Met130 135 140Ala Ala Ala Phe Gln Ala Asp Met Ala Met Thr Ala Gly Ala Ile Val145 150 155 160Ser Gly Ala Phe Phe Gly Asp Lys Met Ser Pro Leu Ser Asp Thr Thr165 170 175Gly Ile Ser Ala Ser Ile Val Gly Ile Asp Leu Phe Glu His Ile Lys180 185 190Asn Met Met Tyr Thr Thr Ile Pro Ala Trp Leu Ile Ser Ala Ala Leu195 200 205Met Leu Trp Leu Leu Pro Ser Val Ala Ala Gln Asp Leu Asn Ser Val210 215 220
Glu Ser Phe Arg Ser Gln Leu Glu Ala Thr Gly Leu Val His Cys Tyr225 230 235 240Ser Leu Ile Pro Phe Ala Leu Leu Val Val Leu Ala Leu Met Arg Val245 250 255Asn Ala Val Val Ala Met Leu Phe Thr Val Ile Ala Ala Val Ala Val260 265 270Thr Tyr Leu His Ser Thr Pro Asp Leu Arg Gln Leu Gly Ala Trp Phe275 280 285Tyr Gly Gly Tyr Lys Leu Glu Gly Glu Ala Phe Lys Asp Ile Ala Lys290 295 300Leu Ile Ser Arg Gly Gly Leu Glu Ser Met Phe Phe Thr Gln Thr Ile305 310 315 320Val Ile Leu Gly Met Ser Leu Gly Gly Leu Leu Phe Ala Leu Gly Ala325 330 335Ile Pro Ser Leu Leu Asp Ala Val Arg Ser Phe Leu Thr Asn Ala Gly340 345 350Arg Ala Thr Phe Ser Val Ala Met Thr Ser Val Gly Val Asn Phe Leu355 360 365Ile Gly Glu Gln Tyr Leu Ser Ile Leu Leu Ser Gly Glu Thr Phe Lys370 375 380Pro Val Tyr Asp Lys Leu Gly Leu His Ser Arg Asn Leu Ser Arg Thr385 390 395 400Leu Glu Asp Ala Gly Thr Val Ile Asn Pro Leu Val Pro Trp Ser Val405 410 415Cys Gly Val Phe Ile Ser His Ala Leu Gly Val Pro Val Trp Glu Tyr420 425 430Leu Pro Tyr Ala Phe Phe Cys Tyr Leu Ser Leu Ala Leu Thr Leu Leu435 440 445Phe Gly Trp Thr Gly Leu Thr Leu Ser Lys Lys450 455<210>63
<211>1098<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1098)<400>63atg gca ggc aac act ttc gga caa ctc ttc acc gtt acc acc ttc ggc48Met Ala Gly Asn Thr Phe Gly Gln Leu Phe Thr Val Thr Thr Phe Gly1 5 10 15gaa agc cac ggc gcg ggt ttg ggc tgt atc atc gac ggc tgc ccg ccc96Glu Ser His Gly Ala Gly Leu Gly Cys Ile Ile Asp Gly Cys Pro Pro20 25 30ggc ttg gaa tta agc gaa gcg gat atc caa ttt gac ctc gac cga cgc144Gly Leu Glu Leu Ser Glu Ala Asp Ile Gln Phe Asp Leu Asp Arg Arg35 40 45aaa ccc ggc acc agc cgc cac gtt acc caa cgc cgc gaa gcc gac caa192Lys Pro Gly Thr Ser Arg His Val Thr Gln Arg Arg Glu Ala Asp Gln50 55 60gtc gaa atc ctc tcc ggc gta ttc gaa ggc aaa acc acc ggc acg ccc240Val Glu Ile Leu Ser Gly Val Phe Glu Gly Lys Thr Thr Gly Thr Pro65 70 75 80atc gcc ctc tta atc cgc aat acc gac cag cgc agc aaa gac tac ggc288Ile Ala Leu Leu Ile Arg Asn Thr Asp Gln Arg Ser Lys Asp Tyr Gly85 90 95aac atc gcc acc agc ttc cgc ccc ggc cac gcc gac tat acc tat tgg336Asn Ile Ala Thr Ser Phe Arg Pro Gly His Ala Asp Tyr Thr Tyr Trp100 105 110cac aaa tac ggc acg cgc gac tac cgg ggc ggc ggc agg agt tcc gcc384His Lys Tyr Gly Thr Arg Asp Tyr Arg Gly Gly Gly Arg Ser Ser Ala115 120 125cgc gaa acc gcc gcc cgc gtt gcc gcc gga gcc gtt gcc aaa aaa tgg432Arg Glu Thr Ala Ala Arg Val Ala Ala Gly Ala Val Ala Lys Lys Trp130 135 140ttg aaa gaa aaa ttc ggc acg gaa atc acc gcc tac gtt acc caa gtc480Leu Lys Glu Lys Phe Gly Thr Glu Ile Thr Ala Tyr Val Thr Gln Val145 150 155 160
ggc gaa aaa gaa atc cgg ttt gaa ggc tgc gaa cac att tcc caa aat528Gly Glu Lys Glu Ile Arg Phe Glu Gly Cys Glu His Ile Ser Gln Asn165 170 175cct ttt ttt gcc gcc aac cat agc caa att gcc gag ctg gaa aac tat576Pro Phe Phe Ala Ala Asn His Ser Gln Ile Ala Glu Leu Glu Asn Tyr180 185 190atg gac agc gtg cgc aaa tcc ttg gat tcc gtc ggc gcg aag ctg cat624Met Asp Ser Val Arg Lys Ser Leu Asp Ser Val Gly Ala Lys Leu His195 200 205att gaa gcc gcc aac gtc ccc gtc ggc ttg ggc gaa ccc gta ttc gac672Ile Glu Ala Ala Asn Val Pro Val Gly Leu Gly Glu Pro Val Phe Asp210 215 220cgc ctc gat gcc gaa atc gcc tac gcc atg atg ggc atc aac gcc gtc720Arg Leu Asp Ala Glu Ile Ala Tyr Ala Met Met Gly Ile Asn Ala Val225 230 235 240aaa ggc gtg gaa atc ggc gca ggt ttt gac agc gta acg caa cgc ggc768Lys Gly Val Glu Ile Gly Ala Gly Phe Asp Ser Val Thr Gln Arg Gly245 250 255agc gaa cac ggc gac gaa ctc acc ccg caa ggc ttc ctg tcc aac cac816Ser Glu His Gly Asp Glu Leu Thr Pro Gln Gly Phe Leu Ser Asn His260 265 270tca ggc ggc atc ctc ggc ggc atc agc acc gga caa gac atc cac gtc864Ser Gly Gly Ile Leu Gly Gly Ile Ser Thr Gly Gln Asp Ile His Val275 280 285aat atc gcc atc aaa ccc acc agc tcc atc gcc acc ccg cgc cgc agt912Asn Ile Ala Ile Lys Pro Thr Ser Ser Ile Ala Thr Pro Arg Arg Ser290 295 300atc gac atc aac ggc aac ccc atc gaa ctc gcc acg cac ggc agg cac960Ile Asp Ile Asn Gly Asn Pro Ile Glu Leu Ala Thr His Gly Arg His305 310 315 320gac ccc tgc gtc ggc ttg cgc gcc gcg ccg att gca gaa gct atg ctg1008Asp Pro Cys Val Gly Leu Arg Ala Ala Pro Ile Ala Glu Ala Met Leu325 330 335gca ttg gtt tta atc gac cac gcc ctg cgc cat cgc gcg caa aat gcg1056Ala Leu Val Leu Ile Asp His Ala Leu Arg His Arg Ala Gln Asn Ala340 345 350
gat gtt cag gtt aat acg ccc gac att acc ctt tca aac aaa1098Asp Val Gln Val Asn Thr Pro Asp Ile Thr Leu Ser Asn Lys355 360 365<210>64<211>366<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>64Met Ala Gly Asn Thr Phe Gly Gln Leu Phe Thr Val Thr Thr Phe Gly1 5 10 15Glu Ser His Gly Ala Gly Leu Gly Cys Ile Ile Asp Gly Cys Pro Pro20 25 30Gly Leu Glu Leu Ser Glu Ala Asp Ile Gln Phe Asp Leu Asp Arg Arg35 40 45Lys Pro Gly Thr Ser Arg His Val Thr Gln Arg Arg Glu Ala Asp Gln50 55 60Val Glu Ile Leu Ser Gly Val Phe Glu Gly Lys Thr Thr Gly Thr Pro65 70 75 80Ile Ala Leu Leu Ile Arg Asn Thr Asp Gln Arg Ser Lys Asp Tyr Gly85 90 95Asn Ile Ala Thr Ser Phe Arg Pro Gly His Ala Asp Tyr Thr Tyr Trp100 105 110His Lys Tyr Gly Thr Arg Asp Tyr Arg Gly Gly Gly Arg Ser Ser Ala115 120 125Arg Glu Thr Ala Ala Arg Val Ala Ala Gly Ala Val Ala Lys Lys Trp130 135 140Leu Lys Glu Lys Phe Gly Thr Glu Ile Thr Ala Tyr Val Thr Gln Val145 150 155 160Gly Glu Lys Glu Ile Arg Phe Glu Gly Cys Glu His Ile Ser Gln Asn165 170 175Pro Phe Phe Ala Ala Asn His Ser Gln Ile Ala Glu Leu Glu Asn Tyr180 185 190
Met Asp Ser Val Arg Lys Ser Leu Asp Ser Val Gly Ala Lys Leu His195 200 205Ile Glu Ala Ala Asn Val Pro Val Gly Leu Gly Glu Pro Val Phe Asp210 215 220Arg Leu Asp Ala Glu Ile Ala Tyr Ala Met Met Gly Ile Asn Ala Val225 230 235 240Lys Gly Val Glu Ile Gly Ala Gly Phe Asp Ser Val Thr Gln Arg Gly245 250 255Ser Glu His Gly Asp Glu Leu Thr Pro Gln Gly Phe Leu Ser Asn His260 265 270Ser Gly Gly Ile Leu Gly Gly Ile Ser Thr Gly Gln Asp Ile His Val275 280 285Asn Ile Ala Ile Lys Pro Thr Ser Ser Ile Ala Thr Pro Arg Arg Ser290 295 300Ile Asp Ile Asn Gly Asn Pro Ile Glu Leu Ala Thr His Gly Arg His305 310 315 320Asp Pro Cys Val Gly Leu Arg Ala Ala Pro Ile Ala Glu Ala Met Leu325 330 335Ala Leu Val Leu Ile Asp His Ala Leu Arg His Arg Ala Gln Asn Ala340 345 350Asp Val Gln Val Asn Thr Pro Asp Ile Thr Leu Ser Asn Lys355 360 365<210>65<211>461<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(459)<400>65atg caa agc ggt ttt aac gct att ttc agg aat gac acc atg cag gtt48Met Gln Ser Gly Phe Asn Ala Ile Phe Arg Asn Asp Thr Met Gln Val1 5 10 15
aca tca aaa tgg ata gac gga atg tgc ttt gtc gga aca acg gaa ggc96Thr Ser Lys Trp Ile Asp Gly Met Cys Phe Val Gly Thr Thr Glu Gly20 25 30ggg cac agc gtc gtt atg gag ggg tcg gcg gca gaa ggt gcg gcc aag144Gly His Ser Val Val Met Glu Gly Ser Ala Ala Glu Gly Ala Ala Lys35 40 45cgc ggg ccc agc cct ttg gaa atg ctg ctg ttg ggc gtg gcg ggc tgt192Arg Gly Pro Ser Pro Leu Glu Met Leu Leu Leu Gly Val Ala Gly Cys50 55 60tcg agc atc gat gtg gtg atg att gcc gaa aaa cag cgt cag aaa gtg240Ser Ser Ile Asp Val Val Met Ile Ala Glu Lys Gln Arg Gln Lys Val65 70 75 80act gac tgc cgt gcg acg gtt acg gcg aaa cgg gcg gac gat gcg ccg288Thr Asp Cys Arg Ala Thr Val Thr Ala Lys Arg Ala Asp Asp Ala Pro85 90 95cgc gtg ttt acc gaa atc cac atc cat ttc aaa gta ttc ggg cat gat336Arg Val Phe Thr Glu Ile His Ile His Phe Lys Val Phe Gly His Asp100 105 110ttg aaa gaa tcg gcc att gag cgc gcc gtt cag atg tct gcc gaa aaa384Leu Lys Glu Ser Ala Ile Glu Arg Ala Val Gln Met Ser Ala Glu Lys115 120 125tac tgt tcg gct tcg att atg ttg ggc aaa gcg gca aag att acc cac432Tyr Cys Ser Ala Ser Ile Met Leu Gly Lys Ala Ala Lys Ile Thr His130 135 140agt ttt gaa att gcc ggg gca gat aaa ta 461Ser Phe Glu Ile Ala Gly Ala Asp Lys145 150<210>66<211>153<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>66Met Gln Ser Gly Phe Asn Ala Ile Phe Arg Asn Asp Thr Met Gln Val1 5 10 15Thr Ser Lys Trp Ile Asp Gly Met Cys Phe Val Gly Thr Thr Glu Gly
20 25 30Gly His Ser Val Val Met Glu Gly Ser Ala Ala Glu Gly Ala Ala Lys35 40 45Arg Gly Pro Ser Pro Leu Glu Met Leu Leu Leu Gly Val Ala Gly Cys50 55 60Ser Ser Ile Asp Val Val Met Ile Ala Glu Lys Gln Arg Gln Lys Val65 70 75 80Thr Asp Cys Arg Ala Thr Val Thr Ala Lys Arg Ala Asp Asp Ala Pro85 90 95Arg Val Phe Thr Glu Ile His Ile His Phe Lys Val Phe Gly His Asp100 105 110Leu Lys Glu Ser Ala Ile Glu Arg Ala Val Gln Met Ser Ala Glu Lys115 120 125Tyr Cys Ser Ala Ser Ile Met Leu Gly Lys Ala Ala Lys Ile Thr His130 135 140Ser Phe Glu Ile Ala Gly Ala Asp Lys145 150<210>67<211>1659<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1659)<400>67atg act gac aac agc cct cct cca aac gga cac gcc caa gca cgc gtc48Met Thr Asp Asn Ser Pro Pro Pro Asn Gly His Ala Gln Ala Arg Val1 5 10 15cgc aaa aac aac acc ttc ctc tct gcc gtc tgg ctg gtt ccg ctg atc96Arg Lys Asn Asn Thr Phe Leu Ser Ala Val Trp Leu Val Pro Leu Ile20 25 30gcg ctg att gcc ggc ggc tgg ctt tgg gtt aag gaa atc cgc aac agg144Ala Leu Ile Ala Gly Gly Trp Leu Trp Val Lys Glu Ile Arg Asn Arg
35 40 45ggg cct gtg gtt acg ctc ttg atg gac agc gcg gaa ggc att gag gtc192Gly Pro Val Val Thr Leu Leu Met Asp Ser Ala Glu Gly Ile Glu Val50 55 60aac aat acg gtc atc aaa gta ttg agc atc gat gtc gga cgc gtt acc240Asn Asn Thr Val Ile Lys Val Leu Ser Ile Asp Val Gly Arg Val Thr65 70 75 80cga atc aaa ctg cgc gac gac caa aaa ggc gtg gaa gta acc gcc caa288Arg Ile Lys Leu Arg Asp Asp Gln Lys Gly Val Glu Val Thr Ala Gln85 90 95ctc aat gcg gac gta tcc ggc ctc atc cgc agc gat acc cag ttt tgg336Leu Asn Ala Asp Val Ser Gly Leu Ile Arg Ser Asp Thr Gln Phe Trp100 105 110gtg gtc aag ccg cgt atc gac caa agc ggc gta acc ggt ttg ggt acg384Val Val Lys Pro Arg Ile Asp Gln Ser Gly Val Thr Gly Leu Gly Thr115 120 125ctg ctt tcg ggt tcg tac atc gcc ttt aca ccc ggc aaa agc gac gag432Leu Leu Ser Gly Ser Tyr Ile Ala Phe Thr Pro Gly Lys Ser Asp Glu130 135 140gca aaa gac gtg ttc caa gtg cag gac att ccg ccc gtt acc gcc atc480Ala Lys Asp Val Phe Gln Val Gln Asp Ile Pro Pro Val Thr Ala Ile145 150 155 160ggg caa agc ggg ctg cgc ttg aat ttg att ggt aaa aac gac cgc atc528Gly Gln Ser Gly Leu Arg Leu Asn Leu Ile Gly Lys Asn Asp Arg Ile165 170 175ctc aac gtc aac agc cct gtt ttg tat gaa aac ttt atg gtc ggg caa576Leu Asn Val Asn Ser Pro Val Leu Tyr Glu Asn Phe Met Val Gly Gln180 185 190gtc gaa agc gcg cat ttc gac ccg tcc gac caa agc gtg cat tac acc624Val Glu Ser Ala His Phe Asp Pro Ser Asp Gln Ser Val His Tyr Thr195 200 205atc ttc atc caa agc ccc aac gac aaa ctg att cat tcc gcc agc cgt672Ile Phe Ile Gln Ser Pro Asn Asp Lys Leu Ile His Ser Ala Ser Arg210 215 220ttc tgg ctg gaa agc ggc atc aat atc gaa acc aca ggc agc ggc atc720Phe Trp Leu Glu Ser Gly Ile Asn Ile Glu Thr Thr Gly Ser Gly Ile
225 230 235 240aaa ctc aat tcc gcc cct ctg cct gcc ctg ctg tcg ggc gcg att tca768Lys Leu Asn Ser Ala Pro Leu Pro Ala Leu Leu Ser Gly Ala Ile Ser245 250 255ttt gat tcg ccg aaa acc aaa aac agt aaa aac gtc aaa agc gaa gac816Phe Asp Ser Pro Lys Thr Lys Asn Ser Lys Asn Val Lys Ser Glu Asp260 265 270agc ttc acg ctt tac gac agc cgc agc gaa gtc gcc aac ctg cct gat864Ser Phe Thr Leu Tyr Asp Ser Arg Ser Glu Val Ala Asn Leu Pro Asp275 280 285gac cgt tcg ctg tac tac acc gcg ttt ttc aaa caa tcc gtg cgc gga912Asp Arg Ser Leu Tyr Tyr Thr Ala Phe Phe Lys Gln Ser Val Arg Gly290 295 300ctg acc gtc ggt tcg cct gtc gag tac aaa ggg ctg aat gtc ggc gtg960Leu Thr Val Gly Ser Pro Val Glu Tyr Lys Gly Leu Asn Val Gly Val305 310 315 320gtt tcc gat gtt cct tat ttc gac cgc aac gac agc ctg cac ctg ttt1008Val Ser Asp Val Pro Tyr Phe Asp Arg Asn Asp Ser Leu His Leu Phe325 330 335gaa aac ggc tgg att ccc gta cgc atc cgt att gag cct tcc cgt ttg1056Glu Asn Gly Trp Ile Pro Val Arg Ile Arg Ile Glu Pro Ser Arg Leu340 345 350gaa atc aat gcc gac gaa caa agc aaa gaa cat tgg aaa caa caa ttt1104Glu Ile Asn Ala Asp Glu Gln Ser Lys Glu His Trp Lys Gln Gln Phe355 360 365cag acg gcc tta aac aaa ggc ctg acc gcc acc atc tcc agc aac aac1152Gln Thr Ala Leu Asn Lys Gly Leu Thr Ala Thr Ile Ser Ser Asn Asn370 375 380ctg ctg acc ggc agc aaa atg att gag ttg aac gat cag cct tcc gcc1200Leu Leu Thr Gly Ser Lys Met Ile Glu Leu Asn Asp Gln Pro Ser Ala385 390 395 400tcg ccc aag ctg cga ccg cat acc gtt tat gca ggc gat acc gtt atc1248Ser Pro Lys Leu Arg Pro His Thr Val Tyr Ala Gly Asp Thr Val Ile405 410 415gcg acc cag ggc ggc ggt ttg gac gat ttg cag gtc aaa ttg gcg gat1296Ala Thr Gln Gly Gly Gly Leu Asp Asp Leu Gln Val Lys Leu Ala Asp
420 425 430ttg ctg gac aag ttc gac aaa ctg cct tta gat aag acg gtt gcc gaa1344Leu Leu Asp Lys Phe Asp Lys Leu Pro Leu Asp Lys Thr Val Ala Glu435 440 445ttg aac ggt tcg ctt gcc gag ctc aaa tcc aca ctc aaa tct gcc aat1392Leu Asn Gly Ser Leu Ala Glu Leu Lys Ser Thr Leu Lys Ser Ala Asn450 455 460gcc gcc cta agc tcc atc gac aaa ctg gtc ggc aaa ccg cag aca caa1440Ala Ala Leu Ser Ser Ile Asp Lys Leu Val Gly Lys Pro Gln Thr Gln465 470 475 480aac att ccg aac gaa ctg aac caa acc ctg aaa gag ttg cgc aca acc1488Asn Ile Pro Asn Glu Leu Asn Gln Thr Leu Lys Glu Leu Arg Thr Thr485 490 495ctg caa ggc gta tcg cct caa tcg cct atc tac ggc gac gta caa aat1536Leu Gln Gly Val Ser Pro Gln Ser Pro Ile Tyr Gly Asp Val Gln Asn500 505 510acg ctg caa agt ttg gac aaa acc tta aaa gac gtt caa ccc gtc att1584Thr Leu Gln Ser Leu Asp Lys Thr Leu Lys Asp Val Gln Pro Val Ile515 520 525aac act ttg aaa gaa aaa ccc aac gcg ctg att ttc aac agc agc agc1632Asn Thr Leu Lys Glu Lys Pro Asn Ala Leu Ile Phe Asn Ser Ser Ser530 535 540aaa gac cct atc ccg aaa gga agc cga1659Lys Asp Pro Ile Pro Lys Gly Ser Arg545 550<210>68<211>553<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>68Met Thr Asp Asn Ser Pro Pro Pro Asn Gly His Ala Gln Ala Arg Val1 5 10 15Arg Lys Asn Asn Thr Phe Leu Ser Ala Val Trp Leu Val Pro Leu Ile20 25 30Ala Leu Ile Ala Gly Gly Trp Leu Trp Val Lys Glu Ile Arg Asn Arg
35 40 45Gly Pro Val Val Thr Leu Leu Met Asp Ser Ala Glu Gly Ile Glu Val50 55 60Asn Asn Thr Val Ile Lys Val Leu Ser Ile Asp Val Gly Arg Val Thr65 70 75 80Arg Ile Lys Leu Arg Asp Asp Gln Lys Gly Val Glu Val Thr Ala Gln85 90 95Leu Asn Ala Asp Val Ser Gly Leu Ile Arg Ser Asp Thr Gln Phe Trp100 105 110Val Val Lys Pro Arg Ile Asp Gln Ser Gly Val Thr Gly Leu Gly Thr115 120 125Leu Leu Ser Gly Ser Tyr Ile Ala Phe Thr Pro Gly Lys Ser Asp Glu130 135 140Ala Lys Asp Val Phe Gln Val Gln Asp Ile Pro Pro Val Thr Ala Ile145 150 155 160Gly Gln Ser Gly Leu Arg Leu Asn Leu Ile Gly Lys Asn Asp Arg Ile165 170 175Leu Asn Val Asn Ser Pro Val Leu Tyr Glu Asn Phe Met Val Gly Gln180 185 190Val Glu Ser Ala His Phe Asp Pro Ser Asp Gln Ser Val His Tyr Thr195 200 205Ile Phe Ile Gln Ser Pro Asn Asp Lys Leu Ile His Ser Ala Ser Arg210 215 220Phe Trp Leu Glu Ser Gly Ile Asn Ile Glu Thr Thr Gly Ser Gly Ile225 230 235 240Lys Leu Asn Ser Ala Pro Leu Pro Ala Leu Leu Ser Gly Ala Ile Ser245 250 255Phe Asp Ser Pro Lys Thr Lys Asn Ser Lys Asn Val Lys Ser Glu Asp260 265 270Ser Phe Thr Leu Tyr Asp Ser Arg Ser Glu Val Ala Asn Leu Pro Asp275 280 285Asp Arg Ser Leu Tyr Tyr Thr Ala Phe Phe Lys Gln Ser Val Arg Gly
290 295 300Leu Thr Val Gly Ser Pro Val Glu Tyr Lys Gly Leu Asn Val Gly Val305 310 315 320Val Ser Asp Val Pro Tyr Phe Asp Arg Asn Asp Ser Leu His Leu Phe325 330 335Glu Asn Gly Trp Ile Pro Val Arg Ile Arg Ile Glu Pro Ser Arg Leu340 345 350Glu Ile Asn Ala Asp Glu Gln Ser Lys Glu His Trp Lys Gln Gln Phe355 360 365Gln Thr Ala Leu Asn Lys Gly Leu Thr Ala Thr Ile Ser Ser Asn Asn370 375 380Leu Leu Thr Gly Ser Lys Met Ile Glu Leu Asn Asp Gln Pro Ser Ala385 390 395 400Ser Pro Lys Leu Arg Pro His Thr Val Tyr Ala Gly Asp Thr Val Ile405 410 415Ala Thr Gln Gly Gly Gly Leu Asp Asp Leu Gln Val Lys Leu Ala Asp420 425 430Leu Leu Asp Lys Phe Asp Lys Leu Pro Leu Asp Lys Thr Val Ala Glu435 440 445Leu Asn Gly Ser Leu Ala Glu Leu Lys Ser Thr Leu Lys Ser Ala Asn450 455 460Ala Ala Leu Ser Ser Ile Asp Lys Leu Val Gly Lys Pro Gln Thr Gln465 470 475 480Asn Ile Pro Asn Glu Leu Asn Gln Thr Leu Lys Glu Leu Arg Thr Thr485 490 495Leu Gln Gly Val Ser Pro Gln Ser Pro Ile Tyr Gly Asp Val Gln Asn500 505 510Thr Leu Gln Ser Leu Asp Lys Thr Leu Lys Asp Val Gln Pro Val Ile515 520 525Asn Thr Leu Lys Glu Lys Pro Asn Ala Leu Ile Phe Asn Ser Ser Ser530 535 540Lys Asp Pro Ile Pro Lys Gly Ser Arg
545 550<210>69<211>330<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(330)<400>69ttg ccg ctg ctt tgt tgt ctt tgg ttt tgg cag cct gcg gcg gtg aaa48Leu Pro Leu Leu cys cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys1 5 10 15aag ccg ctg aag ctc ccg ctg ctg aag cac ctg ccg ccg aag ctc ccg96Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro20 25 30cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg aag cac ctg ccg144Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro35 40 45ccg aag ctc ctg cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg192Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu50 55 60aag ctg ccg cta ccg aag cac ctg ccg ctg aag ctg ccg cta ccg aag240Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys65 70 75 80cac ctg ccg ctg aag ctc ctg ctg ccg aag ctg caa aat aag cat ttt288His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe85 90 95ccg ctt gca aaa aag cag gat acg ttc agt atc ctg ctt ttt330Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe100 105 110<210>70<211>110<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)
<400>70Leu Pro Leu Leu Cys Cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys1 5 10 15Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro20 25 30Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro35 40 45Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu50 55 60Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys65 70 75 80His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe85 90 95Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe100 105 110<210>71<211>2274<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(2274)<400>71atg aca aca tta cat ttc tca ggc ttc ccg cgt gtc ggt gcc ttc cgc48Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg1 5 10 15gaa ttg aaa ttc gca caa gaa aaa tac tgg cgc aaa gaa atc agc gag96Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu20 25 30caa gaa ttg ctg gct gtt gct aaa gac ttg cgc gag aaa aac tgg aaa144Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys35 40 45cac cag gcc gct gcc aac gcc gat tac gtt gcc gta ggc gat ttc act192His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr
50 55 60ttc tac gac cac atc ctc gac ctg caa gtc gcc acc ggc gcg att ccc240Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro65 70 75 80gcc cgc ttc ggc ttc gac agc caa aac cta tct ttg gaa caa ttc ttc288Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe85 90 95caa ctg gcg cgc ggt aac aaa gac caa ttc gct atc gaa atg acc aaa336Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys100 105 110tgg ttc gac acc aac tac cac tac ttg gtg cct gaa ttc cac gcc gat384Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp115 120 125acc gaa ttt aaa gcc aat gcc aaa cac tac gtt caa cag ctg caa gaa432Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu130 135 140gcc caa gct ttg ggc ctg aaa gcc aaa ccg acc gtt gtg ggt ccg ttg480Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu145 150 155 160act ttc ctg tgg gtc ggt aaa gaa aaa ggc gcc gtt gaa ttc gac cgt528Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg165 170 175ctg agc ctg ttg cct aaa ctg ttg cct gtt tac gtt gaa atc ctg act576Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr180 185 190gct ttg gtt gaa gcc ggt gcc gag tgg att caa atc gac gag cct gct624Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala195 200 205ttg act gtt gac ctg cct aaa gaa tgg gta gaa gca tac aaa gac gtt672Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val210 215 220tac gcc act ttg agc aaa gta agt gcc aaa atc ctg ctg agc act tac720Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr225 230 235 240ttc ggt tct gtt gcc gaa cac gcc gca ttg ttg aaa tcc ctg cct gtt768Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val
245 250 255gac ggc ctg cac atc gac ttg gta cgc gct cct gaa caa ctg gat gcg816Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala260 265 270ttc gcc gac tac gac aaa gtt ctg tct gcc ggc gtc att gac ggc cgc864Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg275 280 285aat att tgg cgc gcc aac ctg aac aaa gtt ttg gaa act gtt gag ctt912Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu290 295 300ctg caa gcc aaa ctg ggc gac cgt ttg tgg att tcc agc tct tgc tcg960Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser305 310 315 320ctg ctg cac act ccg ttt gac ttg tca gtt gaa gaa aaa ctg aaa gcc1008Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala325 330 335aac aaa ccc gac ctg tac tct tgg ttg gca ttc acc ctg caa aaa acc1056Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr340 345 350caa gaa ttg cgc gtc ctg aaa gcc gca ttg aac gaa ggc cgt gat tct1104Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser355 360 365gtt gcc gaa gaa ctg gct gcc agc caa gct gct gcc gac tcc cgt gcc1152Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala370 375 380aac agc agc gaa atc cac cgt gca gac gtt gcc aaa cgc ctg gcc gat1200Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp385 390 395 400ttg cct gcc aac gca gac caa cgc aaa tcc cca ttt gcc gac cgt atc1248Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile405 410 415aaa gcg caa caa gca tgg ttg aac ctg cct ctg ctg ccg acg acc aac1296Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn420 425 430atc ggt tct ttc ccg caa act acc gaa atc cgc caa gca cgc gca gcc1344Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala
435 440 445ttc aaa aaa ggc gaa ctg tct gcc gcc gat tac gaa gcc gcg atg aaa1392Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys450 455 460aaa gaa atc gcc ttg gtg gtt gaa gag caa gaa aaa ctg gac ttg gac1440Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp465 470 475 480gta ctg gta cac ggc gaa gcc gag cgt aac gac atg gtt gaa tac ttc1488Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe485 490 495ggc gaa ttg ttg agc ggt ttt gca ttc acc caa tat ggc tgg gta caa1536Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln500 505 510agc tac ggt tct cgc tgc gtt aaa cca ccg att atc ttc ggt gac gta1584Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val515 520 525agc cgt cct gaa gcc atg acc gta gct tgg tct act tac gca caa agc1632Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser530 535 540ctg acc aaa cgc ccg atg aaa ggt atg ttg acc ggc cct gta acc att1680Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile545 550 555 560ctg caa tgg tct ttc gtc cgc aac gat att cct cgc tct acc gtg tgt1728Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys565 570 575aaa caa atc gca ctg gct ctg aac gac gaa gta ttg gat ctg gaa aaa1776Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys580 585 590gca ggc atc aaa gtc atc caa atc gac gaa cct gcc atc cgc gaa ggc1824Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly595 600 605ctg cct ttg aaa cgt gcc gat tgg gat gcc tac ctg aac tgg gcc ggc1872Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly610 615 620gaa tct ttc cgc ctg tcc tct acc ggt tgc gaa gac agc act caa atc1920Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile
625 630 635 640cac acc cat atg tgc tac tct gag ttc aac gac atc ctg cct gcg att1968His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile645 650 655gct gca atg gat gcg gac gtg atc acc atc gag act tca cgt tcc gac2016Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp660 665 670atg gaa ctc ttg acc gcg ttc ggc gaa ttc aaa tac ccg aac gac atc2064Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile675 680 685ggc ccg ggg gtt tac gac atc cac agc ccg cgc gta ccg aca gaa gcc2112Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala690 695 700gaa gtg gag cac ctg ttg cgc aaa gcc atc gag gtt gta ccg gtt gaa2160Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu705 710 715 720cgt ctg tgg gtt aac ccg gac tgc ggc ctg aaa aca cgc ggc tgg aaa2208Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys725 730 735gaa act ctg gaa caa ctc caa gtg atg atg aac gta acc cac aaa ttg2256Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu740 745 750cgt gcc gaa ttg gcg aaa2274Arg Ala Glu Leu Ala Lys755<210>72<211>758<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>72Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg1 5 10 15Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu20 25 30Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys
35 40 45His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr50 55 60Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro65 70 75 80Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe85 90 95Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys100 105 110Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp115 120 125Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu130 135 140Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu145 150 155 160Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg165 170 175Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr180 185 190Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala195 200 205Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val210 215 220Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr225 230 235 240Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val245 250 255Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala260 265 270Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg275 280 285Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu
290 295 300Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser305 310 315 320Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala325 330 335Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr340 345 350Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser355 360 365Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala370 375 380Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp385 390 395 400Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile405 410 415Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn420 425 430Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala435 440 445Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys450 455 460Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp465 470 475 480Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe485 490 495Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln500 505 510Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val515 520 525Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser530 535 540Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile
545 550 555 560Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys565 570 575Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys580 585 590Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly595 600 605Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly610 615 620Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile625 630 635 640His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile645 650 655Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp660 665 670Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp lle675 680 685Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala690 695 700Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu705 710 715 720Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys725 730 735Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu740 745 750Arg Ala Glu Leu Ala Lys755<210>73<211>2118<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)
<220>
<221>CDS<222>(1)..(2118)<400>73atg cgc cgt ttt cta ccg atc gca gcc ata tgc gcc gtc gtc ctg ttg48Met Arg Arg Phe Leu Pro Ile Ala Ala Ile Cys Ala Val Val Leu Leu1 5 10 15tac gga ctg acg gcg gca acc ggc agc acc agt tcg ctg gcg gat tat96Tyr Gly Leu Thr Ala Ala Thr Gly Ser Thr Ser Ser Leu Ala Asp Tyr20 25 30ttc tgg tgg att gtt gcg ttc agc gca atg ctg ctg ctg gtg ttg tcc144Phe Trp Trp Ile Val Ala Phe Ser Ala Met Leu Leu Leu Val Leu Ser35 40 45gcc gtt ttg gca cgt tat gtc ata ttg ctg ttg aaa gac agg cgc gac192Ala Val Leu Ala Arg Tyr Val Ile Leu Leu Leu Lys Asp Arg Arg Asp50 55 60ggc gta ttc ggt tcg cag att gcc aaa cgc ctt tcc ggg atg ttt acg240Gly Val Phe Gly Ser Gln Ile Ala Lys Arg Leu Ser Gly Met Phe Thr65 70 75 80ctg gtt gcc gta ctg ccc ggc gtg ttt ctg ttc ggc gtt tcc gca cag288Leu Val Ala Val Leu Pro Gly Val Phe Leu Phe Gly Val Ser Ala Gln85 90 95ttt atc aac ggc acg att aat tcg tgg ttc ggc aac gat acc cac gag336Phe Ile Asn Gly Thr Ile Asn Ser Trp Phe Gly Asn Asp Thr His Glu100 105 110gcg ctt gaa cgc agc ctc aat ttg agc aag tcc gca ttg aat ctg gcg384Ala Leu Glu Arg Ser Leu Asn Leu Ser Lys Ser Ala Leu Asn Leu Ala115 120 125gca gac aac gcc ctt ggc aac gcc atc ccc gtg cag ata gac ctc atc432Ala Asp Asn Ala Leu Gly Asn Ala Ile Pro Val Gln Ile Asp Leu Ile130 135 140ggc gcg gct tcc ctg ccc ggg gat atg ggc agg gtg ctg gaa cat tac480Gly Ala Ala Ser Leu Pro Gly Asp Met Gly Arg Val Leu Glu His Tyr145 150 155 160gcc ggc agc ggt ttt gcc cag ctt gcc ctg tac aat gcc gca agc ggc528Ala Gly Ser Gly Phe Ala Gln Leu Ala Leu Tyr Asn Ala Ala Ser Gly165 170 175
aaa atc gaa aaa agc atc aac ccg cac aag ctc gat cag ccg ttt cca576Lys Ile Glu Lys Ser Ile Asn Pro His Lys Leu Asp Gln Pro Phe Pro180 185 190ggt aag gcg cgt tgg gaa aaa atc caa cag gcg ggt tcg gtc agg gat624Gly Lys Ala Arg Trp Glu Lys Ile Gln Gln Ala Gly Ser Val Arg Asp195 200 205ttg gaa agc ata ggc ggc gta ttg tac gcg cag ggc tgg ctg tcg gca672Leu Glu Ser Ile Gly Gly Val Leu Tyr Ala Gln Gly Trp Leu Ser Ala210 215 220ggt acg cac aac ggg cgc gat tac gcc ttg ttt ttc cgt cag ccg gtt720Gly Thr His Asn Gly Arg Asp Tyr Ala Leu Phe Phe Arg Gln Pro Val225 230 235 240ccc aaa ggc gtg gca gag gat gcc gtc tta atc gaa aag gca agg gcg768Pro Lys Gly Val Ala Glu Asp Ala Val Leu Ile Glu Lys Ala Arg Ala245 250 255aaa tat gct gag ttg agt tac agc aaa aaa ggt ttg cag acc ttt ttc816Lys Tyr Ala Glu Leu Ser Tyr Ser Lys Lys Gly Leu Gln Thr Phe Phe260 265 270ctg gca acc ctg ctg att gcc tcg ctg ctg tcg att ttt ctt gca ctg864Leu Ala Thr Leu Leu Ile Ala Ser Leu Leu Ser Ile Phe Leu Ala Leu275 280 285gtc atg gca ctg tat ttc gcc cgc cgt ttc gtc gaa ccc gtc cta tcg912Val Met Ala Leu Tyr Phe Ala Arg Arg Phe Val Glu Pro Val Leu Ser290 295 300ctt gcc gag ggg gcg aag gcg gtg gcg caa ggc gat ttc agc cag acg960Leu Ala Glu Gly Ala Lys Ala Val Ala Gln Gly Asp Phe Ser Gln Thr305 310 315 320cgc ccc gtg ttg cgc aac gac gag ttc gga cgc ttg acc aag ttg ttc1008Arg Pro Val Leu Arg Asn Asp Glu Phe Gly Arg Leu Thr Lys Leu Phe325 330 335aac cac atg acc gag cag ctt tcc atc gcc aaa gaa gca gac gag cgc1056Asn His Met Thr Glu Gln Leu Ser Ile Ala Lys Glu Ala Asp Glu Arg340 345 350aac cgc cgg cgc gag gaa gcc gcc aga cat tat ctc gaa tgc gtg ttg1104Asn Arg Arg Arg Glu Glu Ala Ala Arg His Tyr Leu Glu Cys Val Leu355 360 365
gag ggg ctg acc acg ggc gtg gtg gtg ttt gac gaa caa ggc tgt ctg1152Glu Gly Leu Thr Thr Gly Val Val Val Phe Asp Glu Gln Gly Cys Leu370 375 380aaa acc ttc aac aaa gcg gcg gaa cag att ttg ggg atg ccg ctt acc1200Lys Thr Phe Asn Lys Ala Ala Glu Gln Ile Leu Gly Met Pro Leu Thr385 390 395 400ccc ctg tgg ggc agc agc cgg cac ggt tgg cac ggc gtt tcg gcg cag1248Pro Leu Trp Gly Ser Ser Arg His Gly Trp His Gly Val Ser Ala Gln405 410 415cag tcc ctg ctt gcc gaa gtg ttt gcc gcc atc ggc gcg gcg gca ggt1296Gln Ser Leu Leu Ala Glu Val Phe Ala Ala Ile Gly Ala Ala Ala Gly420 425 430acg gac aaa ccg gtc cat gtg aaa tat gcc gcg ccg gac gat gcc aaa1344Thr Asp Lys Pro Val His Val Lys Tyr Ala Ala Pro Asp Asp Ala Lys435 440 445atc ctg ctg ggc aag gca acc gtc ctg ccc gaa gac aac ggc aac ggc1392Ile Leu Leu Gly Lys Ala Thr Val Leu Pro Glu Asp Asn Gly Asn Gly450 455 460gtg gta atg gtg att gac gac atc acc gtt ttg ata cac gcg caa aaa1440Val Val Met Val Ile Asp Asp Ile Thr Val Leu Ile His Ala Gln Lys465 470 475 480gaa gcc gcg tgg ggc gaa gtg gca aaa cgg ctg gca cac gaa atc cgc1488Glu Ala Ala Trp Gly Glu Val Ala Lys Arg Leu Ala His Glu Ile Arg485 490 495aat ccg ctc acg ccc atc cag ctt tct gcc gaa cgg ctg gcg tgg aaa1536Asn Pro Leu Thr Pro Ile Gln Leu Ser Ala Glu Arg Leu Ala Trp Lys500 505 510ttg ggc ggg aag ctg gac gag cag gac gcg caa atc ctg aca cgt tcg1584Leu Gly Gly Lys Leu Asp Glu Gln Asp Ala Gln Ile Leu Thr Arg Ser515 520 525acc gac acc atc atc aaa caa gtg gcg gca tta aaa gaa atg gtc gag1632Thr Asp Thr Ile Ile Lys Gln Val Ala Ala Leu Lys Glu Met Val Glu530 535 540gca ttc cgc aat tac gcg cgt tcc cct tcg ctc aaa ttg gaa aat cag1680Ala Phe Arg Asn Tyr Ala Arg Ser Pro Ser Leu Lys Leu Glu Asn Gln545 550 555 560
gat ttg aac gcc tta atc ggc gat gtg ttg gca ttg tac gaa gct ggt1728Asp Leu Asn Ala Leu Ile Gly Asp Val Leu Ala Leu Tyr Glu Ala Gly565 570 575ccg tgc cgg ttt gcg gcg gaa ctt gcc ggc gaa ccg ctg atg atg gcg1776Pro Cys Arg Phe Ala Ala Glu Leu Ala Gly Glu Pro Leu Met Met Ala580 585 590gcg gat acg acc gcc atg cgg cag gtg ctg cac aat att ttc aaa aat1824Ala Asp Thr Thr Ala Met Arg Gln Val Leu His Asn Ile Phe Lys Asn595 600 605gcc gcc gaa gcg gcg gaa gaa gcc gat gtg ccc gaa gtc agg gta aaa1872Ala Ala Glu Ala Ala Glu Glu Ala Asp Val Pro Glu Val Arg Val Lys610 615 620tcg gaa gcg ggg cag gac gga cgg att gtc ctg aca gtt tgc gac aac1920Ser Glu Ala Gly Gln Asp Gly Arg Ile Val Leu Thr Val Cys Asp Asn625 630 635 640ggc aag ggg ttc ggc agg gaa atg ctg cac aat gcc ttc gag ccg tat1968Gly Lys Gly Phe Gly Arg Glu Met Leu His Asn Ala Phe Glu Pro Tyr645 650 655gta acg gac aaa ccg gct gga acg gga ttg gga ctg ccc gtg gtg aaa2016Val Thr Asp Lys Pro Ala Gly Thr Gly Leu Gly Leu Pro Val Val Lys660 665 670aaa atc att gaa gaa cac ggc ggc cgc atc agc ctg agc aat cag gat2064Lys Ile Ile Glu Glu His Gly Gly Arg Ile Ser Leu Ser Asn Gln Asp675 680 685gcg ggc ggc gcg tgt gtc aga atc atc ttg cca aaa acg gta gaa act2112Ala Gly Gly Ala Cys Val Arg Ile Ile Leu Pro Lys Thr Val Glu Thr690 695 700tat gcg2118Tyr Ala705<210>74<211>706<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>74
Met Arg Arg Phe Leu Pro Ile Ala Ala Ile Cys Ala Val Val Leu Leu1 5 10 15Tyr Gly Leu Thr Ala Ala Thr Gly Ser Thr Ser Ser Leu Ala Asp Tyr20 25 30Phe Trp Trp Ile Val Ala Phe Ser Ala Met Leu Leu Leu Val Leu Ser35 40 45Ala Val Leu Ala Arg Tyr Val Ile Leu Leu Leu Lys Asp Arg Arg Asp50 55 60Gly Val Phe Gly Ser Gln Ile Ala Lys Arg Leu Ser Gly Met Phe Thr65 70 75 80Leu Val Ala Val Leu Pro Gly Val Phe Leu Phe Gly Val Ser Ala Gln85 90 95Phe Ile Asn Gly Thr Ile Asn Ser Trp Phe Gly Asn Asp Thr His Glu100 105 110Ala Leu Glu Arg Ser Leu Asn Leu Ser Lys Ser Ala Leu Asn Leu Ala115 120 125Ala Asp Asn Ala Leu Gly Asn Ala Ile Pro Val Gln Ile Asp Leu Ile130 135 140Gly Ala Ala Ser Leu Pro Gly Asp Met Gly Arg Val Leu Glu His Tyr145 150 155 160Ala Gly Ser Gly Phe Ala Gln Leu Ala Leu Tyr Asn Ala Ala Ser Gly165 170 175Lys Ile Glu Lys Ser Ile Asn Pro His Lys Leu Asp Gln Pro Phe Pro180 185 190Gly Lys Ala Arg Trp Glu Lys Ile Gln Gln Ala Gly Ser Val Arg Asp195 200 205Leu Glu Ser Ile Gly Gly Val Leu Tyr Ala Gln Gly Trp Leu Ser Ala210 215 220Gly Thr His Asn Gly Arg Asp Tyr Ala Leu Phe Phe Arg Gln Pro Val225 230 235 240Pro Lys Gly Val Ala Glu Asp Ala Val Leu Ile Glu Lys Ala Arg Ala245 250 255
Lys Tyr Ala Glu Leu Ser Tyr Ser Lys Lys Gly Leu Gln Thr Phe Phe260 265 270Leu Ala Thr Leu Leu Ile Ala Ser Leu Leu Ser Ile Phe Leu Ala Leu275 280 285Val Met Ala Leu Tyr Phe Ala Arg Arg Phe Val Glu Pro Val Leu Ser290 295 300Leu Ala Glu Gly Ala Lys Ala Val Ala Gln Gly Asp Phe Ser Gln Thr305 310 315 320Arg Pro Val Leu Arg Asn Asp Glu Phe Gly Arg Leu Thr Lys Leu Phe325 330 335Asn His Met Thr Glu Gln Leu Ser Ile Ala Lys Glu Ala Asp Glu Arg340 345 350Asn Arg Arg Arg Glu Glu Ala Ala Arg His Tyr Leu Glu Cys Val Leu355 360 365Glu Gly Leu Thr Thr Gly Val Val Val Phe Asp Glu Gln Gly Cys Leu370 375 380Lys Thr Phe Asn Lys Ala Ala Glu Gln Ile Leu Gly Met Pro Leu Thr385 390 395 400Pro Leu Trp Gly Ser Ser Arg His Gly Trp His Gly Val Ser Ala Gln405 410 415Gln Ser Leu Leu Ala Glu Val Phe Ala Ala Ile Gly Ala Ala Ala Gly420 425 430Thr Asp Lys Pro Val His Val Lys Tyr Ala Ala Pro Asp Asp Ala Lys435 440 445Ile Leu Leu Gly Lys Ala Thr Val Leu Pro Glu Asp Asn Gly Asn Gly450 455 460Val Val Met Val Ile Asp Asp Ile Thr Val Leu Ile His Ala Gln Lys465 470 475 480Glu Ala Ala Trp Gly Glu Val Ala Lys Arg Leu Ala His Glu Ile Arg485 490 495Asn Pro Leu Thr Pro Ile Gln Leu Ser Ala Glu Arg Leu Ala Trp Lys500 505 510
Leu Gly Gly Lys Leu Asp Glu Gln Asp Ala Gln Ile Leu Thr Arg Ser515 520 525Thr Asp Thr Ile Ile Lys Gln Val Ala Ala Leu Lys Glu Met Val Glu530 535 540Ala Phe Arg Asn Tyr Ala Arg Ser Pro Ser Leu Lys Leu Glu Asn Gln545 550 555 560Asp Leu Asn Ala Leu Ile Gly Asp Val Leu Ala Leu Tyr Glu Ala Gly565 570 575Pro Cys Arg Phe Ala Ala Glu Leu Ala Gly Glu Pro Leu Met Met Ala580 585 590Ala Asp Thr Thr Ala Met Arg Gln Val Leu His Asn Ile Phe Lys Asn595 600 605Ala Ala Glu Ala Ala Glu Glu Ala Asp Val Pro Glu Val Arg Val Lys610 615 620Ser Glu Ala Gly Gln Asp Gly Arg Ile Val Leu Thr Val Cys Asp Asn625 630 635 640Gly Lys Gly Phe Gly Arg Glu Met Leu His Asn Ala Phe Glu Pro Tyr645 650 655Val Thr Asp Lys Pro Ala Gly Thr Gly Leu Gly Leu Pro Val Val Lys660 665 670Lys Ile Ile Glu Glu His Gly Gly Arg Ile Ser Leu Ser Asn Gln Asp675 680 685Ala Gly Gly Ala Cys Val Arg Ile Ile Leu Pro Lys Thr Val Glu Thr690 695 700Tyr Ala705<210>75<211>1686<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS
<222>(1)..(1686)<400>75atg tta caa tcc gaa aat tcg aaa aat tta atc tct tgt tca ata aag 48Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys1 5 10 15gct tta cca atc atg att tct acc aac ggc atc acc atg cag ttc ggc 96Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly20 25 30gcg aag ccg ctg ttt gaa aac gta tcc gtt aaa ttc ggc gaa ggc aac 144Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn35 40 45cgc tac ggt ttg atc ggc gcg aac ggc tca ggc aaa tcc acc ttc atg 192Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met50 55 60aaa atc ctc ggc ggc gat ttg gaa cag aca gcc ggc gaa gtg gcg att 240Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile65 70 75 80gaa aac ggc gtg cgt ttg ggt aaa ttg cgc caa gac cag ttt gcc tac 288Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr85 90 95gaa gat atg cgc gtg ctg gac gtg gta atg atg ggt cac acc gaa atg 336Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met100 105 110tgg gcg gcg atg acc gaa cgt gat gcg att tac gcc aat ccc gaa gcc 384Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala115 120 125acc gaa gac gac tac atg aaa gcc gca gaa ctg gaa gcc aag ttc gcc 432Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala130 135 140gaa tac gac ggc tac acc gcc gaa gcg cgt gcc gcc gag ttg ttg agc 480Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser145 150 155 160ggc gtg ggc att tcc gaa gat ttg cac aat gca acc atg gca gaa gtt 528Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val165170 175gcc ccg ggc ttc aaa ctg cgc gta ttg ctg gcg caa gcc ctg ttc tcc 576
Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser180 185 190aag ccg gat gta ttg ctc ttg gac gaa ccg acc aat aac ttg gac att 624Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile195 200 205aat acc atc cgt tgg ttg gaa ggc gtg ttg aac cag tac gac tcc acg 672Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr210 215 220atg att atc atc tcg cac gac cgc cac ttc ttg aac gaa gtc tgc acg 720Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr225 230 235 240cat atg gca gat ttg gat tac aac acc atc acc atc tat ccg ggc aac 768His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn245 250 255tac gac gac tat atg ctc gcc tcc gcc caa tcg cgc gaa cgc gcc ctg 816Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu260 265 270aaa gac aat gcc aag gcg aag gaa aaa ttg cag gaa ttg caa gaa ttt 864Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe275 280 285gtg gcg cgg ttc agt gcc aac aaa tcc aaa gcc cgt cag gca acc agc 912Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser290 295 300cgt ctg aaa cag gca gac aaa atc aaa tcg gag atg gtc gag gtc aaa 960Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys305 310 315 320ccc tct acc cgt caa aac ccg tat atc cgt ttt gaa gcc gat gaa aaa1008Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys325 330 335gcc aag ctg cac cgt cag gct gtg gaa gtt gaa aaa ctg gcg aaa cgc1056Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg340 345 350ttt gaa acc cag ttg ttt aaa aac ctg aac ttt atc ctt gaa gcg gga1104Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly355 360 365caa cgc ctc gcc atc atc ggc ccg aac ggc gcg ggc aaa tcc acc ctg1152
Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu370 375 380ctg aaa ctc ttg gcc ggc gcg tac aac ccc gaa tat tca gac ggt ctg1200Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu385 390 395 400ctg ccg gac gaa ggc agc atc aaa tgg gcg gaa aaa gcc agc gtc ggc1248Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly405 410 415tac tat ccg caa gat cac gaa aac gac ttc gat gtc gat atg gat ttg1296Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu420 425 430agc gaa tgg atg cgc caa tgg ggg cag gac ggc gac gac gaa caa gtc1344Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val435 440 445atc cgc ggc act ttg ggg cgt ttg ctc ttc ggc agt aac gat gtc gtg1392Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val450 455 460aaa aaa gtg aag gtt ctc tcc ggt ggt gaa aaa ggc cgt atg ctt tac1440Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr465 470 475 480ggc aaa ctg ttg ctg ttg aaa ccc aat gtc tta gtc atg gat gaa ccg1488Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro485 490 495acc aac cac atg gac atg gaa agc atc gaa tcc ttg aac atg gcg ctg1536Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu500 505 510gaa aaa tac aac ggc acg ctg att ttc gtc tcc cac gac cgt cag ttc1584Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe515 520 525gtt tct tcc ctg gct acc caa atc att gaa ttg gac ggc aaa ggc gga1632Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly530 535 540tat gaa cac tac ttg ggc gat tac gaa agc tat ctc gag aaa aaa ggc1680Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly545 550 555 560gta gca1686
Val Ala<210>76<211>562<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>76Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys1 5 10 15Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly20 25 30Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn35 40 45Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met50 55 60Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile65 70 75 80Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr85 90 95Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met100 105 110Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala115 120 125Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala130 135 140Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser145 150 155 160Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val165 170 175Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser180 185 190Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile195 200 205
Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr210 215 220Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr225 230 235 240His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn245 250 255Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu260 265 270Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe275 280 285Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser290 295 300Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys305 310 315 320Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys325 330 335Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg340 345 350Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly355 360 365Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu370 375 380Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu385 390 395 400Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly405 410 415Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu420 425 430Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val435 440 445Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val450 455 460
Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr465 470 475 480Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro485 490 495Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu500 505 510Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe515 520 525Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly530 535 540Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly545 550 555 560Val Ala<210>77<211>1773<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1773)<400>77atg agt atc gtg ctg cac ggc gtg gcg gcg ggc aaa ggc att gcc gtc 48Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val1 5 10 15ggt tgc gcc cac ctg att gcg cgc ggt acg gag gaa gtg ccg cag tat 96Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr20 25 30gat gtt gcg gag gcg gac acc gat gcc gaa gcc gaa cgt ttc gat gcc 144Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala35 40 45gcc gtc aaa gcc acg cgc aaa gag ttg gaa cag ctc cgc agc gcg att 192Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile50 55 60
ccc gaa aac gcc ccg acc gag ttg ggc gcg ttc atc tcg ctg cac ctg 240Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu65 70 75 80atg ctc ttg acc gat gtt acc ttg tcg cgc gaa ccc gtc gat att tta 288Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu85 90 95agg gaa caa aaa atc aac gcc gag tgg gca ttg aag cag cag agc gac 336Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp100 105 110aaa ctc gcc gcc caa ttc gac aat atg gac gat gcc tat ttg cgc gaa 384Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu115 120 125cgc aag cag gat atg ctg caa gtc gtc cgc cgc atc cac aac aac ctg 432Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu130 135 140atc ggg cag ggc aac gag ttg gaa gtt gcc gac aac ctg ttt gac gaa 480Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu145 150 155 160acc gtt ctg att gca aac gac ctt tcg ccc gcc gac acg gtt ttg ttt 528Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe165 170 175aaa gag cag cgc att gcc gcc ttc gtt acc gat gcc ggc ggc ccc acc 576Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr180 185 190ggg cat acg gcg att ttg ggc agg agc ttg gac atc ccg tcc gtc gtc 624Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val195 200 205ggg ctg cac aac gcg cgc aaa ctg att acc gag ggc gaa acg gtc att 672Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile210 215 220gtg gac ggt atc aac ggc gtg ttg att atc gcg ccg gat gag tcg gtg 720Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val225 230 235 240ttg aac gaa tac cgc cgc cgt gcc cgc gaa tac cgc agc cac aaa cgc 768Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg245 250 255
gat ttg aac aag ctc aaa aaa acc gcc gcc gcc acc gct gac ggg gtc 816Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val260 265 270tgc atc gag ctt gtg ggc aat ata gaa tcc gcc gaa gac gtg aaa ccg 864Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro275 280 285ctg cac aac ctc ggc gca gac ggc atc ggg ctg ttc cgc agc gag ttt 912Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe290 295 300ctt tac ctg aac cgc gat acg atg ccg tct gaa gac gag cag tac gaa 960Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu305 310 315 320gtg tac agc gcg att gtc aaa aaa atg aaa ggc aaa agc gta acg ata1008Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile325 330 335cgg aca gtc gat ttg ggt gtg gac aaa aac ccg cgc tgg ttc ggg aaa1056Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys340 345 350aac agc acg ccc aac ggc agc ctc aac ccc gcg ctg ggc atg acc ggc1104Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly355 360 365atc cgc ctg tgc ctt gcc gaa ccg gtc atg ttc cgc acc cag atg cgc1152Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg370 375 380gcc atc ctc cgc gcc gcc gcc cac ggc ccc gtg cgg atg atg tgg ccg1200Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro385 390 395 400atg att acc tcc gta tcc gaa gtg cgc cag tgc ctc atc cac ctc gac1248Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp405 410 415acc gcg caa cgc cag ctt gcc gaa cgc ggc gat gcc ttc ggt aaa gtc1296Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val420 425 430ggc atc ggc tgt atg att gaa att ccg tct gcc gcg ctg acc gtc ggc1344Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly435 440 445
agt att ttg aaa ctg gtc gat ttc atc tcc gtc ggt acc aac gac ctg1392Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu450 455 460att caa tac atc ttg tcc gtc gat cgc ggc gac gac agc gtc agc cac1440Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His465 470 475 480ctc tac cag ccc ggc cat ccc gcc gtg ctg aaa atg ctg caa cac gtc1488Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val485 490 495atc cgt acc gcc aac cgc atg gac aaa gac gta tcc gta tgc ggc gag1536Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu500 505 510atg gcg ggc gat acc gcg ttt acc cgc gtt tta ttg ggt atg ggg ctg1584Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu515 520 525cgc cgt ttt tcc atg aac ccc aac aac atc ctg ccc gtc aaa aac atc1632Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile530 535 540att ctg cac agc aat gtc gga cag ctc gaa agc gat att gtg aaa gtc1680Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val545 550 555 560atc cgc tgc gaa gac gaa gag aag tcg gaa aag ctg atc aaa cag atg1728Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met565 570 575aac agc gtg tct gtc gag gaa gaa gcc gac ttc aag ggg cgg aaa1773Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys580 585 590<210>78<211>591<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>78Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val1 5 10 15Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr
20 25 30Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala35 40 45Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile50 55 60Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu65 70 75 80Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu85 90 95Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp100 105 110Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu115 120 125Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu130 135 140Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu145 150 155 160Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe165 170 175Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr180 185 190Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val195 200 205Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile210 215 220Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val225 230 235 240Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg245 250 255Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val260 265 270Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro
275 280 285Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe290 295 300Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu305 310 315 320Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile325 330 335Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys340 345 350Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly355 360 365Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg370 375 380Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro385 390 395 400Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp405 410 415Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val420 425 430Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly435 440 445Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu450 455 460Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His465 470 475 480Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val485 490 495Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu500 505 510Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu515 520 525Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile
530 535 540Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val545 550 555 560Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met565 570 575Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys580 585 590<210>79<211>1062<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1062)<400>79atg gaa aaa gaa ttc agg ata tta aat atc gta tcg gcc aag att tgg 48Met Glu Lys Glu Phe Arg Ile Leu Asn Ile Val Ser Ala Lys Ile Trp1 5 10 15ggt gga ggc gaa caa tat gtc tat gat gtt tca aaa gca ttg ggg ctt 96Gly Gly Gly Glu Gln Tyr Val Tyr Asp Val Ser Lys Ala Leu Gly Leu20 25 30cgg gac tgc aca atg ttt acc gcc gtc aat aaa aat aat gaa ttg atg 144Arg Asp Cys Thr Met Phe Thr Ala Val Asn Lys Asn Asn Glu Leu Met35 40 45cac agg cga ttt tcc gaa gtt tct tcc gtt ttc acg aca cgc ctt cac 192His Arg Arg Phe Ser Glu Val Ser Ser Val Phe Thr Thr Arg Leu His50 55 60acg ctc aac ggg ctg ttt tcg ctc tac gca ctt acc cgc ttt atc cgg 240Thr Leu Asn Gly Leu Phe Ser Leu Tyr Ala Leu Thr Arg Phe Ile Arg65 70 75 80aaa aac cgc att tcc cac ctg atg ata cac acc ggc aaa att gcc gcc 288Lys Asn Arg Ile Ser His Leu Met Ile His Thr Gly Lys Ile Ala Ala85 90 95tta tcc ata ctt ttg aaa aaa ctg acc ggg gtg cgc ctg ata ttt gtc 336
Leu Ser Ile Leu Leu Lys Lys Leu Thr Gly Val Arg Leu Ile Phe Val100 105 110aaa cat aat gtt gtc gcc aac aaa act gat ttt tat cac cgc ctg ata384Lys His Asn Val Val Ala Asn Lys Thr Asp Phe Tyr His Arg Leu Ile115 120 125cag aaa aac acc gac cgc ttt att tgc gtt tcc cgt ctg gtt tac gat432Gln Lys Asn Thr Asp Arg Phe Ile Cys Val Ser Arg Leu Val Tyr Asp130 135 140gtg caa acc gcc gac aat ccc ttt aaa gaa aaa tac cgg att gtt cat480Val Gln Thr Ala Asp Asn Pro Phe Lys Glu Lys Tyr Arg Ile Val His145 150 155 160aac ggt atc gat acc ggc cgt ttc cct ccc cct caa gaa aaa ccc gac528Asn Gly Ile Asp Thr Gly Arg Phe Pro Pro Pro Gln Glu Lys Pro Asp165 170 175agc cgt ttt ttt acc gtc gcc tac gcc ggc agg atc agt ccg gaa aaa576Ser Arg Phe Phe Thr Val Ala Tyr Ala Gly Arg Ile Ser Pro Glu Lys180 185 190gga ttg gaa aac ctg att gaa gcc tgt gtg ata ctg cat cgg aaa tat624Gly Leu Glu Asn Leu Ile Glu Ala Cys Val Ile Leu His Arg Lys Tyr195 200 205cct caa atc agg ctc aaa ttg gca ggg gac gga cat ccg gat tat atg672Pro Gln Ile Arg Leu Lys Leu Ala Gly Asp Gly His Pro Asp Tyr Met210 215 220tgt cgc ctg aag cgg gac gta tct gct tcg gga gca gaa cca ttt gtt720Cys Arg Leu Lys Arg Asp Val Ser Ala Ser Gly Ala Glu Pro Phe Val225 230 235 240tct ttt gaa ggg ttt acc gaa aaa ctt gct tcg ttt tac cgc caa agc768Ser Phe Glu Gly Phe Thr Glu Lys Leu Ala Ser Phe Tyr Arg Gln Ser245 250 255gat gtc gtg gtt ttg ccc agc ctc gtc ccg gag gca ttc ggt ttg tca816Asp Val Val Val Leu Pro Ser Leu Val Pro Glu Ala Phe Gly Leu Ser260 265 270tta tgc gag gcg atg tac tgc cga acg gcg gtg att tcc aat act ttg864Leu Cys Glu Ala Met Tyr Cys Arg Thr Ala Val Ile Ser Asn Thr Leu275 280 285ggc gcg caa aag gaa att atc gaa cat cat caa tcg ggg att ctg ctg912
Gly Ala Gln Lys Glu Ile Ile Glu His His Gln Ser Gly Ile Leu Leu290 295 300gat agg ctg aca cct gaa tct ttg gcg gac gaa atc gaa cgc ctc gtc960Asp Arg Leu Thr Pro Glu Ser Leu Ala Asp Glu Ile Glu Arg Leu Val305 310 315 320tta aac cct gaa acg aaa aac gca ctg gca acg gca gga cat caa tgc1008Leu Asn Pro Glu Thr Lys Asn Ala Leu Ala Thr Ala Gly His Gln Cys325 330 335gtc gcc aac cgt ttt acc atc aac cat acc gcc gac aaa tta ttg gat1056Val Ala Asn Arg Phe Thr Ile Asn His Thr Ala Asp Lys Leu Leu Asp340 345 350gca ata1062Ala Ile<210>80<211>354<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>80Met Glu Lys Glu Phe Arg Ile Leu Asn Ile Val Ser Ala Lys Ile Trp1 5 10 15Gly Gly Gly Glu Gln Tyr Val Tyr Asp Val Ser Lys Ala Leu Gly Leu20 25 30Arg Asp Cys Thr Met Phe Thr Ala Val Asn Lys Asn Asn Glu Leu Met35 40 45His Arg Arg Phe Ser Glu Val Ser Ser Val Phe Thr Thr Arg Leu His50 55 60Thr Leu Asn Gly Leu Phe Ser Leu Tyr Ala Leu Thr Arg Phe Ile Arg65 70 75 80Lys Asn Arg Ile Ser His Leu Met Ile His Thr Gly Lys Ile Ala Ala85 90 95Leu Ser Ile Leu Leu Lys Lys Leu Thr Gly Val Arg Leu Ile Phe Val100 105 110Lys His Asn Val Val Ala Asn Lys Thr Asp Phe Tyr His Arg Leu Ile115 120 125
Gln Lys Asn Thr Asp Arg Phe Ile Cys Val Ser Arg Leu Val Tyr Asp130 135 140Val Gln Thr Ala Asp Asn Pro Phe Lys Glu Lys Tyr Arg Ile Val His145 150 155 160Asn Gly Ile Asp Thr Gly Arg Phe Pro Pro Pro Gln Glu Lys Pro Asp165 170 175Ser Arg Phe Phe Thr Val Ala Tyr Ala Gly Arg Ile Ser Pro Glu Lys180 185 190Gly Leu Glu Asn Leu Ile Glu Ala Cys Val Ile Leu His Arg Lys Tyr195 200 205Pro Gln Ile Arg Leu Lys Leu Ala Gly Asp Gly His Pro Asp Tyr Met210 215 220Cys Arg Leu Lys Arg Asp Val Ser Ala Ser Gly Ala Glu Pro Phe Val225 230 235 240Ser Phe Glu Gly Phe Thr Glu Lys Leu Ala Ser Phe Tyr Arg Gln Ser245 250 255Asp Val Val Val Leu Pro Ser Leu Val Pro Glu Ala Phe Gly Leu Ser260 265 270Leu Cys Glu Ala Met Tyr Cys Arg Thr Ala Val Ile Ser Asn Thr Leu275 280 285Gly Ala Gln Lys Glu Ile Ile Glu His His Gln Ser Gly Ile Leu Leu290 295 300Asp Arg Leu Thr Pro Glu Ser Leu Ala Asp Glu Ile Glu Arg Leu Val305 310 315 320Leu Asn Pro Glu Thr Lys Asn Ala Leu Ala Thr Ala Gly His Gln Cys325 330 335Val Ala Asn Arg Phe Thr Ile Asn His Thr Ala Asp Lys Leu Leu Asp340 345 350Ala Ile
<210>81<211>795<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(795)<400>81atg gcg gct gtt ttt tct gta tgt gcc tgt ttt atg tgt tcc tgc ctt48Met Ala Ala Val Phe Ser Val Cys Ala Cys Phe Met Cys Ser Cys Leu1 5 10 15gtt gtc aaa aat acc gtt atc gga agc gga cgc acc aaa atc gcc gtg96Val Val Lys Asn Thr Val Ile Gly Ser Gly Arg Thr Lys Ile Ala Val20 25 30ccg ctt gtc gcc cgc gat gcc gcc gta ctt tcc gcc gta ctt gac caa144Pro Leu Val Ala Arg Asp Ala Ala Val Leu Ser Ala Val Leu Asp Gln35 40 45atc aaa aac ctg ccc ttc gat atc gtc gag ttc cgc gcc gat ttt ttg192Ile Lys Asn Leu Pro Phe Asp Ile Val Glu Phe Arg Ala Asp Phe Leu50 55 60gaa tgc gcg ggc agc atc ggc gaa gta ttg cgc cac acg cag acc gtc240Glu Cys Ala Gly Ser Ile Gly Glu Val Leu Arg His Thr Gln Thr Val65 70 75 80cgc gac gcg cta ccc gac aag ccg ctg ctg ttt acg ttc aga cgg cat288Arg Asp Ala Leu Pro Asp Lys Pro Leu Leu Phe Thr Phe Arg Arg His85 90 95ggc gaa ggc ggc tcg ttc ccg tgt tcg gac gat tat tat ttt gaa ctg336Gly Glu Gly Gly Ser Phe Pro Cys Ser Asp Asp Tyr Tyr Phe Glu Leu100 105 110ctc gac gcg ctg atc gaa agc cgc ctg ccc gac atc atc gac atc gag384Leu Asp Ala Leu Ile Glu Ser Arg Leu Pro Asp Ile Ile Asp Ile Glu115 120 125ctg ttt tcc ggc gaa acc gcc gtc cgg tgc gcc gtg gca aat gct caa432Leu Phe Ser Gly Glu Thr Ala Val Arg Cys Ala Val Ala Asn Ala Gln130 135 140aaa aac ggc atc gcc gcc ctg ctc tgc aat cat gag ttt cac cgc acg480Lys Asn Gly Ile Ala Ala Leu Leu Cys Asn His Glu Phe His Arg Thr
145 150 155 160ccg ccg caa gaa gaa atc gta tgc cgt ctg aaa cag atg gag gac tgc528Pro Pro Gln Glu Glu Ile Val Cys Arg Leu Lys Gln Met Glu Asp Cys165 170 175ggc gcg gac atc tgc aaa att gcg gtg atg ccg caa agc gcg gaa gat576Gly Ala Asp Ile Cys Lys Ile Ala Val Met Pro Gln Ser Ala Glu Asp180 185 190gtg ctg act ttg ctt tcc gcc acg ctc aaa gcg aaa gag ctt gcc gcc624Val Leu Thr Leu Leu Ser Ala Thr Leu Lys Ala Lys Glu Leu Ala Ala195 200 205aaa ccg att gtt acg atg tcg atg ggg cag acg ggg gcg gtc agc cgg672Lys Pro Ile Val Thr Met Ser Met Gly Gln Thr Gly Ala Val Ser Arg210 215 220ctt gcc gga cag gtg ttc ggc tca agc atc acg ttc ggt tcg gga acg720Leu Ala Gly Gln Val Phe Gly Ser Ser Ile Thr Phe Gly Ser Gly Thr225 230 235 240caa aac tcc gcg ccg ggg caa atc ggc gta tcc gcc ctc cgt gcg aca768Gln Asn Ser Ala Pro Gly Gln Ile Gly Val Ser Ala Leu Arg Ala Thr245 250 255ctc gac tgc ctc gaa aac gga gca gac795Leu Asp Cys Leu Glu Asn Gly Ala Asp260 265<210>82<211>265<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>82Met Ala Ala Val Phe Ser Val Cys Ala Cys Phe Met Cys Ser Cys Leu1 5 10 15Val Val Lys Asn Thr Val Ile Gly Ser Gly Arg Thr Lys Ile Ala Val20 25 30Pro Leu Val Ala Arg Asp Ala Ala Val Leu Ser Ala Val Leu Asp Gln35 40 45Ile Lys Asn Leu Pro Phe Asp Ile Val Glu Phe Arg Ala Asp Phe Leu50 55 60
Glu Cys Ala Gly Ser Ile Gly Glu Val Leu Arg His Thr Gln Thr Val65 70 75 80Arg Asp Ala Leu Pro Asp Lys Pro Leu Leu Phe Thr Phe Arg Arg His85 90 95Gly Glu Gly Gly Ser Phe Pro Cys Ser Asp Asp Tyr Tyr Phe Glu Leu100 105 110Leu Asp Ala Leu Ile Glu Ser Arg Leu Pro Asp Ile Ile Asp Ile Glu115 120 125Leu Phe Ser Gly Glu Thr Ala Val Arg Cys Ala Val Ala Asn Ala Gln130 135 140Lys Asn Gly Ile Ala Ala Leu Leu Cys Asn His Glu Phe His Arg Thr145 150 155 160Pro Pro Gln Glu Glu Ile Val Cys Arg Leu Lys Gln Met Glu Asp Cys165 170 175Gly Ala Asp Ile Cys Lys Ile Ala Val Met Pro Gln Ser Ala Glu Asp180 185 190Val Leu Thr Leu Leu Ser Ala Thr Leu Lys Ala Lys Glu Leu Ala Ala195 200 205Lys Pro Ile Val Thr Met Ser Met Gly Gln Thr Gly Ala Val Ser Arg210 215 220Leu Ala Gly Gln Val Phe Gly Ser Ser Ile Thr Phe Gly Ser Gly Thr225 230 235 240Gln Asn Ser Ala Pro Gly Gln Ile Gly Val Ser Ala Leu Arg Ala Thr245 250 255Leu Asp Cys Leu Glu Asn Gly Ala Asp260 265<210>83<211>876<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(876)<400>83ttg acc gtc cga acg aaa aag acg gcg cat tat acc cta ttc cat tcc48Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser1 5 10 15gac cga aaa ccg aac atg act act ctc aaa ccc gcc ctg ccc gct tat96Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr20 25 30ctg gac aac atc cgc atc atc ctc acg cgc acc agc cat ccc gcc aac144Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn35 40 45atc ggc tct gcc gcg cgc gcg atg aaa aca atg ggt ctg cac aaa ctg192Ile Gly ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu50 55 60acc atc gtc gcc cca aat ctg atg gca acg ccg atg acg gaa aac ccg240Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro65 70 75 80ccc gtg ttt gac ccg gag cat cct caa tcg ttt aaa tta ccg gaa gaa288Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu85 90 95agc ttc atc ctc gct tcc ggc gcg gca gac gtt ttg gaa aat gcc acc336Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr100 105 110att gcc gct tct ttg gac gaa gcc ctt gcc gac acc acc atc gcc tgc384Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys115 120 125gcc ctg acc agc cgc cgc cgc gaa att act gcg ccg ctg caa acc ccg432Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro130 135 140cgc gat ttg gta tcc gaa tta ctg cag acc gca aac cga ggc gag aaa480Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys145 150 155 160gtg gca ctg gtt ttc ggc aac gag act ttc ggc ttg agc atc gaa gaa528Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu165 170 175
gtc caa gcc tgc aac cga ctg atg acc atc aac ggc aat ccc gac tat576Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr180 185 190ttc tcg ctc aac ctc gcc caa gcc gtg cag gtc gtg tgc tac gaa atc624Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile195 200 205ttc agc caa acc ggt tcg ccc atg acc cat ctt caa caa gaa gac cac672Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His210 215 220gct gcg acc cac gag caa atc aaa ggc atg gtc gcc cac atg gaa agc720Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser225 230 235 240gtg atg aac gac atc ggc ttt ttc aac cgc cgc aac ggc gag cgt ctg768Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu245 250 255atg cgc cgt atg cag agc ctg ttc gga cgc gcc aac acg caa acc gaa816Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu260 265 270gac atc gat atc ctg cgc ggt ttt ttc aat acc gtc agc cat cgt atc864Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile275 280 285cat aaa aaa gac876His Lys Lys Asp290<210>84<211>292<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>84Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser1 5 10 15Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr20 25 30Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn35 40 45
Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu50 55 60Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro65 70 75 80Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu85 90 95Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr100 105 110Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys115 120 125Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro130 135 140Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys145 150 155 160Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu165 170 175Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr180 185 190Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile195 200 205Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His210 215 220Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser225 230 235 240Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu245 250 255Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu260 265 270Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile275 280 285His Lys Lys Asp290
<210>85<211>1545<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1545)<400>85gtg cgt ctc aat cat ttc ata atg ata gcg att att ata tat gtg att48Val Arg Leu Asn His Phe Ile Met Ile Ala Ile Ile Ile Tyr Val Ile1 5 10 15tcc cct gca aac aag ccg gcc cgc cgc cac agc gtt ccc act tat ccg96Ser Pro Ala Asn Lys Pro Ala Arg Arg His Ser Val Pro Thr Tyr Pro20 25 30gct ttg cct tat aat tgc ttt ttt tat gta aca gat tta cct atg aat144Ala Leu Pro Tyr Asn Cys Phe Phe Tyr Val Thr Asp Leu Pro Met Asn35 40 45ttc ccc aaa aca gcg gcc tcc ctg ctg ctg ctt ctc gcc tcc ctc gcc192Phe Pro Lys Thr Ala Ala Ser Leu Leu Leu Leu Leu Ala Ser Leu Ala50 55 60gca cac gcg ctc gat aca ggt cgc att ccg caa aac gaa atc gcc gta240Ala His Ala Leu Asp Thr Gly Arg Ile Pro Gln Asn Glu Ile Ala Val65 70 75 80tat gtc caa gag ctt gac agc gga aaa gtc atc att gac cac cgc tcg288Tyr Val Gln Glu Leu Asp Ser Gly Lys Val Ile Ile Asp His Arg Ser85 90 95gat gtc ccc gtc aac ccc gcc tcc aca atg aaa ctc gtt acc gcg ttt336Asp Val Pro Val Asn Pro Ala Ser Thr Met Lys Leu Val Thr Ala Phe100 105 110gcc gcc ttc aaa acc ttc ggc agc aat tac cgc tgg gcg acc gag ttt384Ala Ala Phe Lys Thr Phe Gly Ser Asn Tyr Arg Trp Ala Thr Glu Phe115 120 125aaa agc aac ggt acg gta aac gac ggc acg ctt gac gga aac ctg tat432Lys Ser Asn Gly Thr Val Asn Asp Gly Thr Leu Asp Gly Asn Leu Tyr130 135 140
tgg gcg ggc agc ggc gac ccc gtt ttc aat cag gaa aac ctg ctt gcc480Trp Ala Gly Ser Gly Asp Pro Val Phe Asn Gln Glu Asn Leu Leu Ala145 150 155 160gtc caa cgc cag ttg cgc gaa caa ggc ata cgc aat atc acg gga cac528Val Gln Arg Gln Leu Arg Glu Gln Gly Ile Arg Asn Ile Thr Gly His165 170 175ctg atg ctc gac cac agc ctg tgg ggc gaa gtc ggc agc ccc gac gat576Leu Met Leu Asp His Ser Leu Trp Gly Glu Val Gly Ser Pro Asp Asp180 185 190ttc gaa gcc gac agc ggt tcg ccg ttt atg acg ccc ccc aat cca act624Phe Glu Ala Asp Ser Gly Ser Pro Phe Met Thr Pro Pro Asn Pro Thr195 200 205atg ctg tct gcc ggt atg gtt atg gtg cgc gcc gaa cgc aat gcc gcc672Met Leu Ser Ala Gly Met Val Met Val Arg Ala Glu Arg Asn Ala Ala210 215 220gac agt acc gac atc ctc acc gat ccg cct ttg ccg cat att ttc gcc720Asp Ser Thr Asp Ile Leu Thr Asp Pro Pro Leu Pro His Ile Phe Ala225 230 235 240caa aac aac ttg aaa att acc gcc tcc caa gct gcc tgc cct tcg atc768Gln Asn Asn Leu Lys Ile Thr Ala Ser Gln Ala Ala Cys Pro Ser Ile245 250 255aaa aaa ctg atg cgt gca tct ttt tcg gac aat acg ctg aaa ttg cgc816Lys Lys Leu Met Arg Ala Ser Phe Ser Asp Asn Thr Leu Lys Leu Arg260 265 270ggc aat att ccc gag agc tgt ttg ggc aag cct gtc ggt gtc cgg atg864Gly Asn Ile Pro Glu Ser Cys Leu Gly Lys Pro Val Gly Val Arg Met275 280 285ttc gcg ctt gac gaa ctg atc cgg caa agt ttt acc aac cac tgg ctg912Phe Ala Leu Asp Glu Leu Ile Arg Gln Ser Phe Thr Asn His Trp Leu290 295 300ctc ggc ggc gga cgg att tca gac ggc atc ggc ata tcc gac acg ccg960Leu Gly Gly Gly Arg Ile Ser Asp Gly Ile Gly Ile Ser Asp Thr Pro305 310 315 320gaa ggc gcg cag acg ctt gcc gtt gca cac tca aag ccg atg aag gaa1008Glu Gly Ala Gln Thr Leu Ala Val Ala His Ser Lys Pro Met Lys Glu325 330 335
att ttg acg gac atg aac aag cgt tcg gac aat cta att gcg cgt tcc1056Ile Leu Thr Asp Met Asn Lys Arg Ser Asp Asn Leu Ile Ala Arg Ser340 345 350gtc ttc ctc aaa ctc ggc ggc gac ggc aaa ctg ccc gcc gtt tcc gaa1104Val Phe Leu Lys Leu Gly Gly Asp Gly Lys Leu Pro Ala Val Ser Glu355 360 365cag gca gcg tct gcc gtc cgg cgt gaa ctt gcc gtg tcg ggc atc gat1152Gln Ala Ala Ser Ala Val Arg Arg Glu Leu Ala Val Ser Gly Ile Asp370 375 380gtt gcg gat ttg gtt ttg gaa aac ggt tca ggt ctg tcc aga aaa gaa1200Val Ala Asp Leu Val Leu Glu Asn Gly Ser Gly Leu Ser Arg Lys Glu385 390 395 400agg gta acg gcg aga atg atg gcg caa atg ttg gaa acg gct tat ttc1248Arg Val Thr Ala Arg Met Met Ala Gln Met Leu Glu Thr Ala Tyr Phe405 410 415agc ccg ttt gca caa gat ttc atc gat acg ctg ccc atc gcc ggc aca1296Ser Pro Phe Ala Gln Asp Phe Ile Asp Thr Leu Pro Ile Ala Gly Thr420 425 430gac ggg act tta cgc aac cgc ttc aaa caa agc ggc ggg ctg ttg cgc1344Asp Gly Thr Leu Arg Asn Arg Phe Lys Gln Ser Gly Gly Leu Leu Arg435 440 445tta aaa acc ggc acg ctc aac aat gtc cgc gcc ctt gca ggt tat tgg1392Leu Lys Thr Gly Thr Leu Asn Asn Val Arg Ala Leu Ala Gly Tyr Trp450 455 460ctg ggc gac aaa ccg atg gcg gtg gtc gtc atc atc aac agc ggc cgc1440Leu Gly Asp Lys Pro Met Ala Val Val Val Ile Ile Asn Ser Gly Arg465 470 475 480gcc gtt tcc ctg ctg ccc gac ttg gac aac ttc gtt gcc aac aac atc1488Ala Val Ser Leu Leu Pro Asp Leu Asp Asn Phe Val Ala Asn Asn Ile485 490 495atc tcc ggc ggc gat ggc tgg ctg gat gcg aaa ctg atg tgc aaa gaa1536Ile Ser Gly Gly Asp Gly Trp Leu Asp Ala Lys Leu Met Cys Lys Glu500 505 510cgc cga gcc1545Arg Arg Ala515
<210>86<211>515<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>86Val Arg Leu Asn His Phe Ile Met Ile Ala Ile Ile Ile Tyr Val Ile1 5 10 15Ser Pro Ala Asn Lys Pro Ala Arg Arg His Ser Val Pro Thr Tyr Pro20 25 30Ala Leu Pro Tyr Asn Cys Phe Phe Tyr Val Thr Asp Leu Pro Met Asn35 40 45Phe Pro Lys Thr Ala Ala Ser Leu Leu Leu Leu Leu Ala Ser Leu Ala50 55 60Ala His Ala Leu Asp Thr Gly Arg Ile Pro Gln Asn Glu Ile Ala Val65 70 75 80Tyr Val Gln Glu Leu Asp Ser Gly Lys Val Ile Ile Asp His Arg Ser85 90 95Asp Val Pro Val Asn Pro Ala Ser Thr Met Lys Leu Val Thr Ala Phe100 105 110Ala Ala Phe Lys Thr Phe Gly Ser Asn Tyr Arg Trp Ala Thr Glu Phe115 120 125Lys Ser Asn Gly Thr Val Asn Asp Gly Thr Leu Asp Gly Asn Leu Tyr130 135 140Trp Ala Gly Ser Gly Asp Pro Val Phe Asn Gln Glu Asn Leu Leu Ala145 150 155 160Val Gln Arg Gln Leu Arg Glu Gln Gly Ile Arg Asn Ile Thr Gly His165 170 175Leu Met Leu Asp His Ser Leu Trp Gly Glu Val Gly Ser Pro Asp Asp180 185 190Phe Glu Ala Asp Ser Gly Ser Pro Phe Met Thr Pro Pro Asn Pro Thr195 200 205Met Leu Ser Ala Gly Met Val Met Val Arg Ala Glu Arg Asn Ala Ala210 215 220
Asp Ser Thr Asp Ile Leu Thr Asp Pro Pro Leu Pro His Ile Phe Ala225 230 235 240Gln Asn Asn Leu Lys Ile Thr Ala Ser Gln Ala Ala Cys Pro Ser Ile245 250 255Lys Lys Leu Met Arg Ala Ser Phe Ser Asp Asn Thr Leu Lys Leu Arg260 265 270Gly Asn Ile Pro Glu Ser Cys Leu Gly Lys Pro Val Gly Val Arg Met275 280 285Phe Ala Leu Asp Glu Leu Ile Arg Gln Ser Phe Thr Asn His Trp Leu290 295 300Leu Gly Gly Gly Arg Ile Ser Asp Gly Ile Gly Ile Ser Asp Thr Pro305 310 315 320Glu Gly Ala Gln Thr Leu Ala Val Ala His Ser Lys Pro Met Lys Glu325 330 335Ile Leu Thr Asp Met Asn Lys Arg Ser Asp Asn Leu Ile Ala Arg Ser340 345 350Val Phe Leu Lys Leu Gly Gly Asp Gly Lys Leu Pro Ala Val Ser Glu355 360 365Gln Ala Ala Ser Ala Val Arg Arg Glu Leu Ala Val Ser Gly Ile Asp370 375 380Val Ala Asp Leu Val Leu Glu Asn Gly Ser Gly Leu Ser Arg Lys Glu385 390 395 400Arg Val Thr Ala Arg Met Met Ala Gln Met Leu Glu Thr Ala Tyr Phe405 410 415Ser Pro Phe Ala Gln Asp Phe Ile Asp Thr Leu Pro Ile Ala Gly Thr420 425 430Asp Gly Thr Leu Arg Asn Arg Phe Lys Gln Ser Gly Gly Leu Leu Arg435 440 445Leu Lys Thr Gly Thr Leu Asn Asn Val Arg Ala Leu Ala Gly Tyr Trp450 455 460Leu Gly Asp Lys Pro Met Ala Val Val Val Ile Ile Asn Ser Gly Arg465 470 475 480
Ala Val Ser Leu Leu Pro Asp Leu Asp Asn Phe Val Ala Asn Asn Ile485 490 495Ile Ser Gly Gly Asp Gly Trp Leu Asp Ala Lys Leu Met Cys Lys Glu500 505 510Arg Arg Ala515<210>87<211>840<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(840)<400>87atg gat aaa gaa cga att tta acc ccc gca gtc gtg ttt tcc gtc gca48Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala1 5 10 15ctg ctg cat ttg gca atg gtg gca ttg ctc tgg cag gcg cac aag ctg96Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu20 25 30ccc gtg ata gag tca ggc aat gtt att gaa ttt gtc gat ttg ggc gat144Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp35 40 45ttt ggc gga ggg gac ggc gca ccc gaa ggt gca ggc gcg cct gcc gcg192Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala50 55 60ccc gaa ccg caa ccc gtg ccc gag ccg ccc aaa cct gtc gag ccg ccc240Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro65 70 75 80aag ccg gtt ttg aag ccg gtg gtt acg aaa aag gcg gat gcg gat att288Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile85 90 95cag cag cct aag gaa gag ccg aaa cct gaa gaa aag ccg aaa ccc gaa336Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu
100 105 110gaa aaa ccg aaa cca gag cct aag ccg gaa gcg aag cct gtc ccg aaa384Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys115 120 125ccg gcg gaa aaa ccg gtc gag aag ccg tct gaa aaa cct gcc gaa cat432Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His130 135 140ccc ggc aat gct tct gcc aaa gca gac agc gag cag ggc aat ggg gaa480Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu145 150 155 160gat aag gga acc ggt atc aaa gga gac gga acg ggg cgc gga gaa ggc528Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly165 170 175agc ggt aaa ggt agc ggc ggt gtc aaa ggc gaa cac ggg gaa gga gcc576Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala180 185 190ggc agc agc aaa ggc aat cct tta cgc gcc aac ggc agc att ccg cgc624Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg195 200 205ccg gct tat ccc acg ctt tct atg gag aat gat gag cag ggt acg gtt672Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val210 215 220gtt ttg agc gtt ttg gtt tct ccg ggc ggt cat gtt gag tcc gtt aaa720Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys225 230 235 240atc gtg aaa agc agt ggt ttt tcc cgg ttg gac aat gcg gca cgc aag768Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys245 250 255gcg gcg caa aac ggg cat ttt caa gcc aat gcc tgg acg gag ttt aaa816Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys260 265 270gtc ccc gtc aag ttt gaa ttg aat840Val Pro Val Lys Phe Glu Leu Asn275 280<210>88
<211>280<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>88Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala1 5 10 15Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu20 25 30Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp35 40 45Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala50 55 60Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro65 70 75 80Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile85 90 95Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu100 105 110Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys115 120 125Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His130 135 140Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu145 150 155 160Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly165 170 175Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala180 185 190Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg195 200 205Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val210 215 220Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys
225 230 235 240Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys245 250 255Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys260 265 270Val Pro Val Lys Phe Glu Leu Asn275 280<210>89<211>1584<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1584)<400>89atg gca ctt ttc ctc agc ata ttc ccc atc gtc ctg ctg att tgg ctg48Met Ala Leu Phe Leu Ser Ile Phe Pro Ile Val Leu Leu Ile Trp Leu1 5 10 15atg gtg aaa aaa aac agt atg ccc tcc tac gtc gcg ctg ccg att acc96Met Val Lys Lys Asn Ser Met Pro Ser Tyr Val Ala Leu Pro Ile Thr20 25 30gca gtg ctg att tac gcc atc aaa ctt ttc tac ttc gac gat gcg ggc144Ala Val Leu Ile Tyr Ala Ile Lys Leu Phe Tyr Phe Asp Asp Ala Gly35 40 45atg ctg ctc aac gcc acc gcc gct tcc ggc ctc gtc aaa acg ctc acg192Met Leu Leu Asn Ala Thr Ala Ala Ser Gly Leu Val Lys Thr Leu Thr50 55 60ccg att acc gtg att ttc ggc gcg att atg ttc aac cgt atg atg gaa240Pro Ile Thr Val Ile Phe Gly Ala Ile Met Phe Asn Arg Met Met Glu65 70 75 80acc acg ggc tgc atc gat gtc atc cgc aaa tgg ctg gcg acc atc agc288Thr Thr Gly Cys Ile Asp Val Ile Arg Lys Trp Leu Ala Thr Ile Ser85 90 95ccc aac ccc gta gcg caa ctg atg att atc ggc tgg gct ttt gcc ttt336
Pro Asn Pro Val Ala Gln Leu Met Ile Ile Gly Trp Ala Phe Ala Phe100 105 110atg att gaa ggc gca tcc ggc ttc ggc acg cct gcc gcg att gcc gcg384Met Ile Glu Gly Ala Ser Gly Phe Gly Thr Pro Ala Ala Ile Ala Ala115 120 125ccg att ctg atg agc ttg ggc ttc aac ccg ttg aaa gtg gcg att ttc432Pro Ile Leu Met Ser Leu Gly Phe Asn Pro Leu Lys Val Ala Ile Phe130 135 140act ttg gtg atg aac tcc gtc ccc gtc tct ttc ggc gcg gtc ggt acg480Thr Leu Val Met Asn Ser Val Pro Val Ser Phe Gly Ala Val Gly Thr145 150 155 160ccg acc tgg ttc ggt ttc gca ccg ctg aac ctg agt gcc gaa gac atc528Pro Thr Trp Phe Gly Phe Ala Pro Leu Asn Leu Ser Ala Glu Asp Ile165 170 175ctc gcc atc ggc agg cag acc ggc gta atg cac ttc ttc gca ggt ttc576Leu Ala Ile Gly Arg Gln Thr Gly Val Met His Phe Phe Ala Gly Phe180 185 190gtc atc ccc gtc atc ggc ttg ggc ttc atc gta cct tgg tct gaa atc624Val Ile Pro Val Ile Gly Leu Gly Phe Ile Val Pro Trp Ser Glu Ile195 200 205cgc aaa aac ttg ggc ttc gtc gcc att gcc gtc ttc tcc tgc acc att672Arg Lys Asn Leu Gly Phe Val Ala Ile Ala Val Phe Ser Cys Thr Ile210 215 220cct tat gtc gca ttg gcg atg gtc aac gaa gaa ttc ccg tcg ctc gtc720Pro Tyr Val Ala Leu Ala Met Val Asn Glu Glu Phe Pro Ser Leu Val225 230 235 240gcc ggc gcg atc ggc ctg atg gtg tcc gta ttc gcc gcc aac caa ggc768Ala Gly Ala Ile Gly Leu Met Val Ser Val Phe Ala Ala Asn Gln Gly245 250 255tgg ggc ttg agc aaa gac cac gcc aaa gac ccg aat gcc gaa aaa gtg816Trp Gly Leu Ser Lys Asp His Ala Lys Asp Pro Asn Ala Glu Lys Val260 265 270ccg ttc gcc caa gtc gcc aaa gca ctc gcc cct ttg ggt atg ctg atc864Pro Phe Ala Gln Val Ala Lys Ala Leu Ala Pro Leu Gly Met Leu Ile275 280 285ggc atg ctg gtg gtt acg cgc atc aaa cag ctc ggc atc aaa ggc att912
Gly Met Leu Val Val Thr Arg Ile Lys Gln Leu Gly Ile Lys Gly Ile290 295 300ttg acc agc aaa gaa gaa tgg ttc agc ttc caa ctg ccg ttt gat ttg960Leu Thr Ser Lys Glu Glu Trp Phe Ser Phe Gln Leu Pro Phe Asp Leu305 310 315 320tcc aaa atc acc gtc agc gac tcc ctg acg att act ttc ggc aat att1008Ser Lys Ile Thr Val Ser Asp Ser Leu Thr Ile Thr Phe GlV Asn Ile325 330 335ttc gga caa gat gtc agc gcg tct tac caa acg ctg tac gtc ccg gct1056Phe Gly Gln Asp Val Ser Ala Ser Tyr Gln Thr Leu Tyr Val Pro Ala340 345 350tgg att ccg ttt gtg ctg acc gtt tgg att tgc atc ctg ctg tat aaa1104Trp Ile Pro Phe Val Leu Thr Val Trp Ile Cys Ile Leu Leu Tyr Lys355 360 365acc aaa ttc aaa gat gcc tgg acg att tat tcc gta act ttc aat caa1152Thr Lys Phe Lys Asp Ala Trp Thr Ile Tyr Ser Val Thr Phe Asn Gln370 375 380acc aaa aaa ccg ctg ctt gcc ctg atg ggc gcg ctg att atg gtt cag1200Thr Lys Lys Pro Leu Leu Ala Leu Met Gly Ala Leu Ile Met Val Gln385 390 395 400ctg atg ctg gtc ggc ggc gac aat tcg atg gtg aaa atc atc ggt aag1248Leu Met Leu Val Gly Gly Asp Asn Ser Met Val Lys Ile Ile Gly Lys405 410 415gaa ttt gcc gca atg gcg ggc gaa cac tgg gtt tat ttc tcg ccg tat1296Glu Phe Ala Ala Met Ala Gly Glu His Trp Val Tyr Phe Ser Pro Tyr420 425 430ctg ggc gcg atc ggt gcg ttc ttc tcc ggt tcc aac acc gtg tcc aac1344Leu Gly Ala Ile Gly Ala Phe Phe Ser Gly Ser Asn Thr Val Ser Asn435 440 445ctg acc ttc ggc ccg att cag cag caa atc gcc ttg gat acc ggc ctg1392Leu Thr Phe Gly Pro Ile Gln Gln Gln Ile Ala Leu Asp Thr Gly Leu450 455 460tcc gtt acc ctg att ctg gcg ttg cag tcc gtc ggc ggc gcg atg ggc1440Ser Val Thr Leu Ile Leu Ala Leu Gln Ser Val Gly Gly Ala Met Gly465 470 475 480aat atg gtg tgc ctc aac aac atc atc gcc gta tgt acc gta ttg gat1488
Asn Met Val Cys Leu Asn Asn Ile Ile Ala Val Cys Thr Val Leu Asp485 490 495gtg aaa aat tcc gaa ggt gcg att atc aag aaa acc gtt atc ccg atg1536Val Lys Asn Ser Glu Gly Ala Ile Ile Lys Lys Thr Val Ile Pro Met500 505 510gcg att tac ggc gtg att gcc gtc gtc gcg gca atg att ttc ttc ctc1584Ala Ile Tyr Gly Val Ile Ala Val Val Ala Ala Met Ile Phe Phe Leu515 520 525<210>90<211>528<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>90Met Ala Leu Phe Leu Ser Ile Phe Pro Ile Val Leu Leu Ile Trp Leu1 5 10 15Met Val Lys Lys Asn Ser Met Pro Ser Tyr Val Ala Leu Pro Ile Thr20 25 30Ala Val Leu Ile Tyr Ala Ile Lys Leu Phe Tyr Phe Asp Asp Ala Gly35 40 45Met Leu Leu Asn Ala Thr Ala Ala Ser Gly Leu Val Lys Thr Leu Thr50 55 60Pro Ile Thr Val Ile Phe Gly Ala Ile Met Phe Asn Arg Met Met Glu65 70 75 80Thr Thr Gly Cys Ile Asp Val Ile Arg Lys Trp Leu Ala Thr Ile Ser85 90 95Pro Asn Pro Val Ala Gln Leu Met Ile Ile Gly Trp Ala Phe Ala Phe100 105 110Met Ile Glu Gly Ala Ser Gly Phe Gly Thr Pro Ala Ala Ile Ala Ala115 120 125Pro Ile Leu Met Ser Leu Gly Phe Asn Pro Leu Lys Val Ala Ile Phe130 135 140Thr Leu Val Met Asn Ser Val Pro Val Ser Phe Gly Ala Val Gly Thr145 150 155 160
Pro Thr Trp Phe Gly Phe Ala Pro Leu Asn Leu Ser Ala Glu Asp Ile165 170 175Leu Ala Ile Gly Arg Gln Thr Gly Val Met His Phe Phe Ala Gly Phe180 185 190Val Ile Pro Val Ile Gly Leu Gly Phe Ile Val Pro Trp Ser Glu Ile195 200 205Arg Lys Asn Leu Gly Phe Val Ala Ile Ala Val Phe Ser Cys Thr Ile210 215 220Pro Tyr Val Ala Leu Ala Met Val Asn Glu Glu Phe Pro Ser Leu Val225 230 235 240Ala Gly Ala Ile Gly Leu Met Val Ser Val Phe Ala Ala Asn Gln Gly245 250 255Trp Gly Leu Ser Lys Asp His Ala Lys Asp Pro Asn Ala Glu Lys Val260 265 270Pro Phe Ala Gln Val Ala Lys Ala Leu Ala Pro Leu Gly Met Leu Ile275 280 285Gly Met Leu Val Val Thr Arg Ile Lys Gln Leu Gly Ile Lys Gly Ile290 295 300Leu Thr Ser Lys Glu Glu Trp Phe Ser Phe Gln Leu Pro Phe Asp Leu305 310 315 320Ser Lys Ile Thr Val Ser Asp Ser Leu Thr Ile Thr Phe Gly Asn Ile325 330 335Phe Gly Gln Asp Val Ser Ala Ser Tyr Gln Thr Leu Tyr Val Pro Ala340 345 350Trp Ile Pro Phe Val Leu Thr Val Trp Ile Cys Ile Leu Leu Tyr Lys355 360 365Thr Lys Phe Lys Asp Ala Trp Thr Ile Tyr Ser Val Thr Phe Asn Gln370 375 380Thr Lys Lys Pro Leu Leu Ala Leu Met Gly Ala Leu Ile Met Val Gln385 390 395 400Leu Met Leu Val Gly Gly Asp Asn Ser Met Val Lys Ile Ile Gly Lys405 410 415
Glu Phe Ala Ala Met Ala Gly Glu His Trp Val Tyr Phe Ser Pro Tyr420 425 430Leu Gly Ala Ile Gly Ala Phe Phe Ser Gly Ser Asn Thr Val Ser Asn435 440 445Leu Thr Phe Gly Pro Ile Gln Gln Gln Ile Ala Leu Asp Thr Gly Leu450 455 460Ser Val Thr Leu Ile Leu Ala Leu Gln Ser Val Gly Gly Ala Met Gly465 470 475 480Asn Met Val Cys Leu Asn Asn Ile Ile Ala Val Cys Thr Val Leu Asp485 490 495Val Lys Asn Ser Glu Gly Ala Ile Ile Lys Lys Thr Val Ile Pro Met500 505 510Ala Ile Tyr Gly Val Ile Ala Val Val Ala Ala Met Ile Phe Phe Leu515 520 525<210>91<211>1686<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1686)<400>91atg tta caa tcc gaa aat tcg aaa aat tta atc tct tgt tca ata aag48Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys1 5 10 15gct tta cca atc atg att tct acc aac ggc atc acc atg cag ttc ggc96Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly20 25 30gcg aag ccg ctg ttt gaa aac gta tcc gtt aaa ttc ggc gaa ggc aac144Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn35 40 45cgc tac ggt ttg atc ggc gcg aac ggc tca ggc aaa tcc acc ttc atg192Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met50 55 60
aaa atc ctc ggc ggc gat ttg gaa cag aca gcc ggc gaa gtg gcg att240Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile65 70 75 80gaa aac ggc gtg cgt ttg ggt aaa ttg cgc caa gac cag ttt gcc tac288Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr85 90 95gaa gat atg cgc gtg ctg gac gtg gta atg atg ggt cac acc gaa atg336Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met100 105 110tgg gcg gcg atg acc gaa cgt gat gcg att tac gcc aat ccc gaa gcc384Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala115 120 125acc gaa gac gac tac atg aaa gcc gca gaa ctg gaa gcc aag ttc gcc432Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala130 135 140gaa tac gac ggc tac acc gcc gaa gcg cgt gcc gcc gag ttg ttg agc480Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser145 150 155 160ggc gtg ggc att tcc gaa gat ttg cac aat gca acc atg gca gaa gtt528Gly Val Gly Ile Ser Glu Asp Lau His Asn Ala Thr Met Ala Glu Val165 170 175gcc ccg ggc ttc aaa ctg cgc gta ttg ctg gcg caa gcc ctg ttc tcc576Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser180 185 190aag ccg gat gta ttg ctc ttg gac gaa ccg acc aat aac ttg gac att624Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile195 200 205aat acc atc cgt tgg ttg gaa ggc gtg ttg aac cag tac gac tcc acg672Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr210 215 220atg att atc atc tcg cac gac cgc cac ttc ttg aac gaa gtc tgc acg720Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr225 230 235 240cat atg gca gat ttg gat tac aac acc atc acc atc tat ccg ggc aac768His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr IIe Tyr Pro Gly Asn245 250 255
tac gac gac tat atg ctc gcc tcc gcc caa tcg cgc gaa cgc gcc ctg816Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu260 265 270aaa gac aat gcc aag gcg aag gaa aaa ttg cag gaa ttg caa gaa ttt864Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe275 280 285gtg gcg cgg ttc agt gcc aac aaa tcc aaa gcc cgt cag gca acc agc912Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser290 295 300cgt ctg aaa cag gca gac aaa atc aaa tcg gag atg gtc gag gtc aaa960Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys305 310 315 320ccc tct acc cgt caa aac ccg tat atc cgt ttt gaa gcc gat gaa aaa1008Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys325 330 335gcc aag ctg cac cgt cag gct gtg gaa gtt gaa aaa ctg gcg aaa cgc1056Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg340 345 350ttt gaa acc cag ttg ttt aaa aac ctg aac ttt atc ctt gaa gcg gga1104Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly355 360 365caa cgc ctc gcc atc atc ggc ccg aac ggc gcg ggc aaa tcc acc ctg1152Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu370 375 380ctg aaa ctc ttg gcc ggc gcg tac aac ccc gaa tat tca gac ggt ctg1200Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu385 390 395 400ctg ccg gac gaa ggc agc atc aaa tgg gcg gaa aaa gcc agc gtc ggc1248Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly405 410 415tac tat ccg caa gat cac gaa aac gac ttc gat gtc gat atg gat ttg1296Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu420 425 430agc gaa tgg atg cgc caa tgg ggg cag gac ggc gac gac gaa caa gtc1344Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val435 440 445
atc cgc ggc act ttg ggg cgt ttg ctc ttc ggc agt aac gat gtc gtg1392Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val450 455 460aaa aaa gtg aag gtt ctc tcc ggt ggt gaa aaa ggc cgt atg ctt tac1440Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr465 470 475 480ggc aaa ctg ttg ctg ttg aaa ccc aat gtc tta gtc atg gat gaa ccg1488Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro485 490 495acc aac cac atg gac atg gaa agc atc gaa tcc ttg aac atg gcg ctg1536Thr Asn His Met Mep Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu500 505 510gaa aaa tac aac ggc acg ctg att ttc gtc tcc cac gac cgt cag ttc1584Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe515 520 525gtt tct tcc ctg gct acc caa atc att gaa ttg gac ggc aaa ggc gga1632Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly530 535 540tat gaa cac tac ttg ggc gat tac gaa agc tat ctc gag aaa aaa ggc1680Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly545 550 555 560gta gca1686Val Ala<210>92<211>562<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>92Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys1 5 10 15Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly20 25 30Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn35 40 45
Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met50 55 60Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile65 70 75 80Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr85 90 95Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met100 105 110Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala115 120 125Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala130 135 140Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser145 150 155 160Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val165 170 175Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser180 185 190Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile195 200 205Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr210 215 220Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr225 230 235 240His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn245 250 255Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu260 265 270Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe275 280 285Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser290 295 300
Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys305 310 315 320Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys325 330 335Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg340 345 350Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly355 360 365Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu370 375 380Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu385 390 395 400Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly405 410 415Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu420 425 430Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val435 440 445Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val450 455 460Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr465 470 475 480Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro485 490 495Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu500 505 510Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe515 520 525Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly530 535 540Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly545 550 555 560
Val Ala<210>93<211>1126<212>DMA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1125)<400>93atg aac acc tcg caa cgc aac cgc ctc gtc agc cgc tgg ctc aac tcc48Met Asn Thr Ser Gln Arg Asn Arg Leu Val Ser Arg Trp Leu Asn Ser1 5 10 15tac gaa cgc tac cgc tac cgc cgc ctc atc cac gcc gtc cgg ctc ggc96Tyr Glu Arg Tyr Arg Tyr Arg Arg Leu Ile His Ala Val Arg Leu Gly20 25 30ggg gcc gtc ctg ttc gcc acc gcc tcc gcc cgg ctg ctc cac ctc caa144Gly Ala Val Leu Phe Ala Thr Ala Ser Ala Arg Leu Leu His Leu Gln35 40 45cac ggc gag tgg ata ggg atg acc gtc ttc gtc gtc ctc ggc atg ctc192His Gly Glu Trp Ile Gly Met Thr Val Phe Val Val Leu Gly Met Leu50 55 60cag ttt caa ggg gcg att tac tcc aag gcg gtg gaa cgt atg ctc ggc240Gln Phe Gln Gly Ala Ile Tyr Ser Lys Ala Val Glu Arg Met Leu Gly65 70 75 80acg gtc atc ggg ctg ggc gcg ggt ttg ggc gtt tta tgg ctg aac cag288Thr Val Ile Gly Leu Gly Ala Gly Leu Gly Val Leu Trp Leu Asn Gln85 90 95cat tat ttc cac ggc aac ctc ctc ttc tac ctc acc gtc ggc acg gca336His Tyr Phe His Gly Asn Leu Leu Phe Tyr Leu Thr Val Gly Thr Ala100 105 110agc gca ctg gcc ggc tgg gcg gcg gtc ggc aaa aac ggc tac gtc cct384Ser Ala Leu Ala Gly Trp Ala Ala Val Gly Lys Asn Gly Tyr Val Pro115 120 125atg ctg gcg ggg ctg acg atg tgc atg ctc atc ggc gac aac ggc agc432
Met Leu Ala Gly Leu Thr Met Cys Met Leu Ile Gly Asp Asn Gly Ser130 135 140gaa tgg ttc gac agc ggc ctg atg cgc gcg atg aac gtc ctc atc ggc480Glu Trp Phe Asp Ser Gly Leu Met Arg Ala Met Asn Val Leu Ile Gly145 150 155 160gcg gcc atc gcc atc gcc gcc gcc aaa ctg ctg ccg ctg aaa tcc aca528Ala Ala Ile Ala Ile Ala Ala Ala Lys Leu Leu Pro Leu Lys Ser Thr165 170 175ctg atg tgg cgt ttc atg ctt gcc gac aac ctg acc gac tgc agc aaa576Leu Met Trp Arg Phe Met Leu Ala Asp Asn Leu Thr Asp Cys Ser Lys180 185 190atg att gcc gaa atc agc aac ggc agg cgc atg acc cgc gaa cgc ctc624Met Ile Ala Glu Ile Ser Asn Gly Arg Arg Met Thr Arg Glu Arg Leu195 200 205gaa gag aac atg gcg aaa atg cgc caa atc aac gca cgc atg gtc aaa672Glu Glu Asn Met Ala Lys Met Arg Gln Ile Asn Ala Arg Met Val Lys210 215 220agc cgc agc cac ctc gcc gcc aca tcg ggc gaa agc cgc atc agc ccc720Ser Arg Ser His Leu Ala Ala Thr Ser Gly Glu Ser Arg Ile Ser Pro225 230 235 240gcc atg atg gaa gcc atg cag cac gcc cac cgt aaa att gtc aac acc768Ala Met Met Glu Ala Met Gln His Ala His Arg Lys Ile Val Asn Thr245 250 255acc gag ctg ctc ctg acc acc gcc gcc aag ctg caa tct ccc aaa ctc816Thr Glu Leu Leu Leu Thr Thr Ala Ala Lys Leu Gln Ser Pro Lys Leu260 265 270aac ggc agc gaa atc cgg ctg ctt gac cgc cac ttc aca ctg ctc caa864Asn Gly Ser Glu Ile Arg Leu Leu Asp Arg His Phe Thr Leu Leu Gln275 280 285acc gac ctg caa caa acc gtc gcc ctt atc aac ggc aga cac gcc cgc912Thr Asp Leu Gln Gln Thr Val Ala Leu Ile Asn Gly Arg His Ala Arg290 295 300cgc atc cgc atc gac acc gcc atc aac ccc gaa ctg gaa gcc ctc gcc960Arg Ile Arg Ile Asp Thr Ala Ile Asn Pro Glu Leu Glu Ala Leu Ala305 310 315 320gaa cac ctc cac tac caa tgg cag gge ttc ctc tgg ctc agc acc aat1008
Glu His Leu His Tyr Gln Trp Gln Gly Phe Leu Trp Leu Ser Thr Asn325 330 335atg cgt cag gaa att tcc gcc ctc gtc atc ctg ctg caa cgc acc cgc1056Met Arg Gln Glu Ile Ser Ala Leu Val Ile Leu Leu Gln Arg Thr Arg340 345 350cgc aaa tgg ctg gat gcc cac gaa cgc caa cac ctg cgc caa agc ctg1104Arg Lys Trp Leu Asp Ala His Glu Arg Gln His Leu Arg Gln Ser Leu355 360 365ctt gaa aca cgg gaa cac agt t 1126Leu Glu Thr Arg Glu His Ser370 375<210>94<211>375<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>94Met Asn Thr Ser Gln Arg Asn Arg Leu Val Ser Arg Trp Leu Asn Ser1 5 10 15Tyr Glu Arg Tyr Arg Tyr Arg Arg Leu Ile His Ala Val Arg Leu Gly20 25 30Gly Ala Val Leu Phe Ala Thr Ala Ser Ala Arg Leu Leu His Leu Gln35 40 45His Gly Glu Trp Ile Gly Met Thr Val Phe Val Val Leu Gly Met Leu50 55 60Gln Phe Gln Gly Ala Ile Tyr Ser Lys Ala Val Glu Arg Met Leu Gly65 70 75 80Thr Val Ile Gly Leu Gly Ala Gly Leu Gly Val Leu Trp Leu Asn Gln85 90 95His Tyr Phe His Gly Asn Leu Leu Phe Tyr Leu Thr Val Gly Thr Ala100 105 110Ser Ala Leu Ala Gly Trp Ala Ala Val Gly Lys Asn Gly Tyr Val Pro115 120 125Met Leu Ala Gly Leu Thr Met Cys Met Leu Ile Gly Asp Asn Gly Ser130 135 140
Glu Trp Phe Asp Ser Gly Leu Met Arg Ala Met Asn Val Leu Ile Gly145 150 155 160Ala Ala Ile Ala Ile Ala Ala Ala Lys Leu Leu Pro Leu Lys Ser Thr165 170 175Leu Met Trp Arg Phe Met Leu Ala Asp Asn Leu Thr Asp Cys Ser Lys180 185 190Met Ile Ala Glu Ile Ser Asn Gly Arg Arg Met Thr Arg Glu Arg Leu195 200 205Glu Glu Asn Met Ala Lys Met Arg Gln Ile Asn Ala Arg Met Val Lys210 215 220Ser Arg Ser His Leu Ala Ala Thr Ser Gly Glu Ser Arg Ile Ser Pro225 230 235 240Ala Met Met Glu Ala Met Gln His Ala His Arg Lys Ile Val Asn Thr245 250 255Thr Glu Leu Leu Leu Thr Thr Ala Ala Lys Leu Gln Ser Pro Lys Leu260 265 270Asn Gly Ser Glu Ile Arg Leu Leu Asp Arg His Phe Thr Leu Leu Gln275 280 285Thr Asp Leu Gln Gln Thr Val Ala Leu Ile Asn Gly Arg His Ala Arg290 295 300Arg Ile Arg Ile Asp Thr Ala Ile Asn Pro Glu Leu Glu Ala Leu Ala305 310 315 320Glu His Leu His Tyr Gln Trp Gln Gly Phe Leu Trp Leu Ser Thr Asn325 330 335Met Arg Gln Glu Ile Ser Ala Leu Val Ile Leu Leu Gln Arg Thr Arg340 345 350Arg Lys Trp Leu Asp Ala His Glu Arg Gln His Leu Arg Gln Ser Leu355 360 365Leu Glu Thr Arg Glu His Ser370 375
<210>95<211>1725<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1725)<400>95atg cag cta tca ggc gcg caa atc ata gtg cag agt ctc aaa gcc gaa48Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu1 5 10 15ggt gtc gag tac gtt ttc ggt tat ccc ggc ggt gcg gtt atc gaa atc96Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile20 25 30tac gat gcc ctt ttc caa ctc aat aaa ttc aag cac att ctg acc cgt144Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile Leu Thr Arg35 40 45cac gag cag gcg gca gta cac gcg gca gat gcg tat gcg cgc gtc agc192His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser50 55 60ggt aag gtg ggc gtg gca ttg gtt aca tcc ggc ccg ggc gtt acc aat240Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn65 70 75 80gca ctg acc ggt att gct act gcc tat acg gat tcg att ccg atg gtg288Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val85 90 95gtc atc agc ggg cag gta ggc aat tcc ctg att ggt acg gat gcg ttc336Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe100 105 110caa gaa gtt gat acg gtg ggt att acc cgt ccg tgc gtc aaa cac aat384Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn115 120 125ttc ctg gtt acg gac atc aat gag ttg gcg gaa acc att aaa aag gcg432Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala130 135 140ttc caa att gcc gca agc ggc cga ccg ggg ccc gtg gtg gtt gat gtc480Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val
145 150 155 160ccg aaa gat gtt acg cag gcg atg gcg aaa ttc agc tat cct cag gaa528Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu165 170 175gac att ttt atc cgt tcg tat caa ccg gtt gtt caa ggg cat atc ggt576Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly180 185 190cag att aaa aag gcc gtg cag atg ttg gca tct gcc aaa cgt ccg gtc624Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val195 200 205gtc tat ttt ggc ggc ggc gtg gtg ttg ggt aat gct tct gaa gag ctg672Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu210 215 220acc cga ttt gtc cga atg acg ggt gct ccg tgc acg ggt acg ctg atg720Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met225 230 235 240ggc ttg ggc gct tat cct tcc ggc gac cgc caa ttc ctc ggt atg ctc768Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu245 250 255ggt atg cac ggt act tac gag gca aac ctt gcc atg cag aat gcg gat816Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp260 265 270gtc gtt ctt gcc gta ggt gcg cgt ttt gac gac cgt gtg gtt tcc gta864Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val275 280 285ccg tcc aaa ttt ttc gag aag gcg aag aag gtt atc cat atc gat gtc912Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val290 295 300gat cct tcc agc atc gcc aaa cgc gtg aag gcg gac att ccg att gtc960Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val305 310 315 320ggc gac gtg aaa aac gtt ttg tcc gag atg gtt gcg ctg tgg caa aaa1008Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys325 330 335caa gag tcc gtg ccg tct gaa gat gct ttg ggc aaa tgg tgg aaa acc1056Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr
340 345 350ata gag gaa tgg cgt tcc cgc gat tgc ttg tgg ttt gac aac ggc agc1104Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser355 360 365gaa att atc aag cca caa tat gtg att cag aag ctt gcc gag att acc1152Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr370 375 380ggc aat tcg gca atc atc aca tcg gat gta ggg cag cat caa atg ttt1200Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe385 390 395 400gcg gct caa tat tat ccc ttc gaa cgt ccg cgc caa tgg ctc aac tcc1248Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser405 410 415ggc ggt ttg ggt acg atg ggc gtt ggt ctg cct tat gcg att ggt gca1296Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala420 425 430aaa ctt gcc gcc ccg gat caa gac gta ttc tgt att acc ggc gac ggc1344Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly435 440 445tcg atc cag atg aac atc caa gag ctg tcc acc tgt ttc caa tat cgg1392Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg450 455 460att ccg gtt aac gtc att acg ctg aac aac ggt tat ctc ggt atg gta1440Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val465 470 475 480cgc cag tgg cag gaa ata tat tac ggc gga cga gag tcg gaa acc tat1488Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr485 490 495ttc gat tct ttg ccc gat ttc gtc aaa ctt gcc gag gca tac ggc cat1536Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His500 505 510atc ggt atc cgc gtg gac aag aag tct gat gtg gaa ggt gcg ttg ttg1584Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu515 520 525gaa gca ttg aac caa aaa gac agg ctg gtg ttt atc gac ttc ctg acc1632Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr
530 535 540gac cag aaa cag aat gtg atg ccc atg gtc ggc aac ggc aaa ggt ttg1680Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu545 550 555 560gac gaa atg gta ctt ccg ccg cat atg cgt gcg gac gga aag gcg 1725Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala565 570 575<210>96<211>575<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>96Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu1 5 10 15Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile20 25 30Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile Leu Thr Arg35 40 45His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser50 55 60Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn65 70 75 80Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val85 90 95Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe100 105 110Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn115 120 125Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala130 135 140Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val145 150 155 160Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu
165 170 175Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly180 185 190Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val195 200 205Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu210 215 220Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met225 230 235 240Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu245 250 255Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp260 265 270Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val275 280 285Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val290 295 300Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val305 310 315 320Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys325 330 335Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr340 345 350Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser355 360 365Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr370 375 380Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe385 390 395 400Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser405 410 415Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala
420 425 430Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly435 440 445Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg450 455 460Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val465 470 475 480Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr485 490 495Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His500 505 510Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu515 520 525Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr530 535 540Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu545 550 555 560Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala565 570 575<210>97<211>570<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(570)<400>97atg gac aat cac gcc gaa gca cac tgg caa aac ggc tgg ctt caa agc48Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser1 5 10 15ata cgc cat acc ccg tcg ccc aat ttc agc ccg agg gaa acg ggg gaa96Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu20 25 30
acg gtt tcc ctg atc gtg ttg cac aac att tca ctg ccg ccg ttc gaa144Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu35 40 45tac ggc acg gat gct gtg gaa aag ctg ttt gcc aac cgg ctc gac ccc192Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro50 55 60aac gga cat ccg ttc ttc agc ctg ata cac act ttg cgc gta tcc agc240Asn Gly His Pro Phe Phe Ser Leu Ile His Thr Leu Arg Val Ser Ser65 70 75 80cat ttc tta atc aaa cgc gac ggc aaa acg gtg cag ttc gta tca tgc288His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys85 90 95ggc gat atg gcg tac cac gcg ggc gta tcc tcg ttt cgc gga cgg gaa336Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu100 105 110aaa tgc aac gca ttt tcc atc ggc atc gaa ttg gaa ggc tgc gat ttc384Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe115 120 125gaa ccc ttt acc gaa gcg caa tac cgt tcg ctc gaa aca ttg ttg gaa432Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu130 135 140gca ctc tgc cgc cgc tac ccc gtt acc gca gta acc gga cat cag gac480Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp145 150 155 160atc gcg ccc ggc cgc aaa acc gac ccc ggc cac ttt ttc gac tgg cgg528Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg165 170 175cgg ata cgg gag aaa ggg ttt ccc gta gac aga aat gcc gtc570Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val180 185 190<210>98<211>190<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>98
Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser1 5 10 15Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu20 25 30Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu35 40 45Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro50 55 60Asn Gly His Pro Phe Phe Ser LeuIle His Thr Leu Arg Val Ser Ser65 70 75 80His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys85 90 95Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu100 105 110Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe115 120 125Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu130 135 140Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp145 150 155 160Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg165 170 175Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val180 185 190<210>99<211>1515<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1515)<400>99
atg ttg tat ttc aga tac ggt ttt ttg gtt gtt tgg tgt gcg gca ggt48Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly1 5 10 15gtt tct gcc gcc tat ggg gcg gat gcg ccc gcg att ttg gat gac aag96Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys20 25 30gca ttg ttg cag gtg cag cgg tcg gtg tcg gat aag tgg gcg gaa tcg144Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser35 40 45gat tgg aaa gtt gac aat gat gcc ccg cgc gtg gtt gac ggg gat ttt192Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe50 55 60ttg ttg gcg cat ccg aaa atg ttg gaa cat agt ttg cgc gac gtg ctc240Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu65 70 75 80aac ggc aat cag gcg gat ttg atc gct tcg ttg gcg gat ttg tat gcc288Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala85 90 95aag ctg ccg gat tat gac gcg gtt ttg tac ggc agg gcg cgg gct ttg336Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu100 105 110ctg gcg aaa ttg gcg gga agg ccg gcg gag gcg gtg gcg cgg tat cgg384Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg115 120 125gaa ctg cac ggg gaa aat gcg gca gac gag cgg att ttg ctg gat ttg432Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu130 135 140gcg gcg gcg gag ttt gac gat ttc cgg ctg aag tcg gca gaa agg cat480Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His145 150 155 160ttt gcc gag gcg gaa aaa ttg gat ttg ccg gcg ccg gtt ttg gaa aat528Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn165 170 175gtg ggg cgt ttt cgg aaa aaa gcg gag ggg ctg acg ggc tgg cgt ttt576Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe180 185 190
tcg ggc ggc atc agt ccg gcg gtc aat aga aat gcc aat aat gcc gcg624Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala195 200 205ccg cag tat tgc cgg caa aac gga ggc cgg cag ata tgc agt gtc agc672Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser210 215 220cgg gcg gag cgg gcg gca ggc ttg aat tat gaa atc gag gcg gaa aaa720Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys225 230 235 240ctg acg gcg ttg gca gat aat cat tat ttg ttg ttc cgt tcc aat atc768Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile245 250 255ggc ggc acg agc tat tat ttc agt aaa aaa tca gct tat gac gac ggg816Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly260 265 270ttc ggc aga gcg tat ttg ggt tgg cag tat aaa aat gca cgg cag acg864Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr275 280 285gcg ggg att ttg ccg ttt tat cag gtg cag ttg tcg ggc agc gac ggc912Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly290 295 300ttt gat gcg aaa aca aaa cgg gta aac aac cgc cgc ctg ccg ccg tat960Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr305 310 315 320atg ctg gcg cac gga gtc ggc gtg cag ttg tcc cat act tac cgc cca1008Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro325 330 335aac ccg gga tgg caa ttt tcg gtc gcg ctg gaa cat tac cgc caa cgc1056Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg340 345 350tac cgc gaa cag gat agg gcg gaa tac aat aac ggt cgg cag gac ggg1104Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly355 360 365ttt tat gtt tcg tcg gca aaa cgt ttg ggc gaa tcg gca act gtg ttc1152Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe370 375 380
ggc ggc tgg cag ttt gtg cgg ttt gtg ccg aaa cgc gaa acg gtg ggc1200Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly385 390 395 400ggc gcg gtc aat aat gcc gcc tac cgg cgc aac ggt gtt tat gcc ggc1248Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly405 410 415tgg gcg cag gag tgg cgg cag ttg ggc ggt ttg aac agt cgg gtt tcc1296Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser420 425 430gcg tct tat gcc cgc cgc aac tat aag ggc gtt gcg gct ttc tcg aca1344Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr435 440 445gag gcg caa cgc aac cgc gaa tgg aat gtc tcg ctg gct ttg agc cac1392Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His450 455 460gac aag ttg tcg tac aaa ggt atc gtg ccc gcg ttg aat tat cgt ttc1440Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe465 470 475 480ggc agg acg gaa agt aat gtg ccg tat gcg aaa cgc cgc aac agc gag1488Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu485 490 495gtg ttt gtg tcg gcg gat tgg cgg ttt1515Val Phe Val Ser Ala Asp Trp Arg Phe500 505<210>100<211>505<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>100Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly1 5 10 15Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys20 25 30Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser35 40 45
Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe50 55 60Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu65 70 75 80Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala85 90 95Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu100 105 110Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg115 120 125Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu130 135 140Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His145 150 155 160Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn165 170 175Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe180 185 190Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala195 200 205Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser210 215 220Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys225 230 235 240Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile245 250 255Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly260 265 270Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr275 280 285Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly290 295 300
Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr305 310 315 320Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro325 330 335Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg340 345 350Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly355 360 365Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe370 375 380Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly385 390 395 400Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly405 410 415Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser420 425 430Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr435 440 445Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His450 455 460Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe465 470 475 480Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu485 490 495Val Phe Val Ser Ala Asp Trp Arg Phe500 505<210>101<211>1476<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS
<222>(1)..(1476)<400>101atg aaa tac aaa gac ctg cgc gac ttc atc gcc atg ctc gag cag cag48Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln1 5 10 15ggc aaa ctc aaa cgc atc gcg cac ccc gtt tcc ccg cat ttg gaa atg96Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met20 25 30acc gaa atc gcc gac cgc gtg ctg cgc gcc gaa ggg ccg gcg ttg ttg144Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu35 40 45ttt gaa cac cca gtt aag ccc gac ggt acg cgc tat gat tat ccc gtg192Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val50 55 60ttg gca aac ctg ttc ggc acg ccc gaa cgt gtg gcg atg ggc atg ggc240Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly65 70 75 80gcg gac agc gtg tcc aag ctg cgc gaa atc ggg cag acg ctg gcg tat288Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr85 90 95ttg aaa gaa ccc gaa ccg ccc aaa ggc att aaa gac gcg ttt tcc aaa336Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys100 105 110ctg ccg ctc ttg aaa gac att tgg agc atg gcg ccg aac gtg gtg aaa384Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys115 120 125aat gcg ccg tgt cag gaa atc gta tgg gaa ggc gaa gac gtt gat ttg432Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu130 135 140tat caa ctt ccg att cag cat tgc tgg ccg gaa gac gtt gcg ccg ctg480Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu145 150 155 160gta acg tgg ggc ttg acc gtc acg cgc ggg ccg cac aaa aaa cgc caa528Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln165 170 175aat ctc ggc att tac cgc caa caa tta atc ggc ata aac aag ctg att576
Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile180 185 190atg cgc tgg ctg tcg cat cgc ggc ggc gcg ctg gat tat cag gaa ttc624Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe195 200 205cgc aaa ctc aat ccc gat acg ccg tat ccc gtc gcc gtc gtg ctc ggc672Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly210 215 220tgc gac cct gcc acc att ttg ggc gcg gta acg ccc gtt ccc gat acc720Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr225 230 235 240ttg agc gaa tac cag ttt gcc gga ctg ctg cgc ggt tcg cgg acg gaa768Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu245 250 255ctg gtg aaa tgt atc ggc aac gat ttg caa gtg cct gcc cgc gca gaa816Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu260 265 270atc gtg ttg gaa ggc gtc atc cat cca aac gaa acc gcg ttg gaa ggt864Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly275 280 285cca tac ggc gac cac acg ggc tat tac aac gag cag gac cat ttc ccc912Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro290 295 300gtg ttt acg gtc gaa cgc atc acc atg cgc gaa aac ccg att tac cac960Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His305 310 315 320tct acc tac aca ggc aaa ccg ccc gat gaa ccc gcc gtt ttg ggc gtg1008Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val325 330 335gcg ttg aao gaa gtg ttc gta ccg ctt ttg caa aag cag ttc ccc gaa1056Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu340 345 350atc acc gat ttt tac ctg ccg ccc gaa ggc tgc tcc tac cgc atg gcg1104Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala355 360 365gtg gtg agc atg aaa aaa cag tac gcc gga cac gcc aag cgc gtg atg1152
Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met370 375 380atg ggc tgc tgg tcg ttc ctg cgc cag ttt atg tac acc aaa ttc atc1200Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile385 390 395 400att gtg gtg gat gac gat gtg gat gtg cgc gac tgg aaa gaa gtc atc1248Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile405 410 415tgg gcg gta acc acg cgc atg gac ccc gtg cgc gat acc gtt ttg atg1296Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met420 425 430gaa aac acg ccc atc gac tac ctc gac ttc gcc agc ccc gtc agc gga1344Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly435 440 445ctt ggc ggc aaa atg ggt ttg gat gcg acc aac aag tgg ccg ggc gaa1392Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu450 455 460acc gac cgc gaa tgg gga cgg gtg att aaa aaa gac cct gcg gtt acg1440Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr465 470 475 480gct aag att gat gag att tgg gag gaa ttg ggg ttg1476Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu485 490<210>102<211>492<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>102Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln1 5 10 15Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met20 25 30Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu35 40 45Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val
50 55 60Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly65 70 75 80Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr85 90 95Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys100 105 110Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys115 120 125Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu130 135 140Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu145 150 155 160Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln165 170 175Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile180 185 190Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe195 200 205Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly210 215 220Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr225 230 235 240Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu245 250 255Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu260 265 270Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly275 280 285Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro290 295 300Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His
305 310 315 320Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val325 330 335Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu340 345 350Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala355 360 365Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met370 375 380Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile385 390 395 400Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile405 410 415Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met420 425 430Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly435 440 445Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu450 455 460Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr465 470 475 480Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu485 490<210>103<211>1089<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1089)<400>103atg agt ttg aaa tgc ggc atc gtc ggt ttg ccc aac gtc ggc aaa tcc48
Met Ser Leu Lys Cys Gly Ile Val Gly Leu Pro Asn Val Gly Lys Ser1 5 10 15acc ctt ttt aac gcg ctg acc caa tcg ggt atc gaa gcg gca aac tat96Thr Leu Phe Asn Ala Leu Thr Gln Ser Gly Ile Glu Ala Ala Asn Tyr20 25 30cct ttc tgt acc atc gaa ccc aac gtc ggc atc gtc gaa gtc ccc gat144Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val Glu Val Pro Asp35 40 45ccg cgt atg gcc gaa ttg gca aaa atc gtc aat ccg caa aaa atg cag192Pro Arg Met Ala Glu Leu Ala Lys Ile Val Asn Pro Gln Lys Met Gln50 55 60cct gcc atc gtc gaa ttt gtc gat att gcc ggt ttg gtt gca ggc gcg240Pro Ala Ile Val Glu Phe Val Asp Ile Ala Gly Leu Val Ala Gly Ala65 70 75 80agc aaa ggc gag ggc ttg ggc aac cag ttc ctt gcc aac atc cgc gaa288Ser Lys Gly Glu Gly Leu Gly Asn Gln Phe Leu Ala Asn Ile Arg Glu85 90 95acc gat gcg att gtg aat gtc gtg cgc tgc ttt gac gac gac aac atc336Thr Asp Ala Ile Val Asn Val Val Arg Cys Phe Asp Asp Asp Asn Ile100 105 110gtc cac gtt gca ggc cgc gtc gat ccg att gcc gac att gaa acc atc384Val His Val Ala Gly Arg Val Asp Pro Ile Ala Asp Ile Glu Thr Ile115 120 125ggc aca gag ttg gca ctt gcc gac ctg gca agt gtc gaa aaa gcc atc432Gly Thr Glu Leu Ala Leu Ala Asp Leu Ala Ser Val Glu Lys Ala Ile130 135 140gtc cgc gaa gaa aaa cgc gcc cgc tca ggc gac aaa gac gcg caa aag480Val Arg Glu Glu Lys Arg Ala Arg Ser Gly Asp Lys Asp Ala Gln Lys145 150 155 160ctg gtc gat ttg tgc aaa aaa ctg ctg ccg cat ctg gac gaa ggc aaa528Leu Val Asp Leu Cys Lys Lys Leu Leu Pro His Leu Asp Glu Gly Lys165 170 175ccc gtg cgt tcc ttc ggt ttg gac gcg gaa gaa cgc gcg atg ctc aaa576Pro Val Arg Ser Phe Gly Leu Asp Ala Glu Glu Arg Ala Met Leu Lys180 185 190ccg ctg ttc ctg ctg acc gcc aaa ccg gcg atg tat gtg ggc aac gtc624
Pro Leu Phe Leu Leu Thr Ala Lys Pro Ala Met Tyr Val Gly Asn Val195 200 205gcc gaa gac ggt ttt gaa aac aat ccg cac ctc gac cgc ctg aaa gaa672Ala Glu Asp Gly Phe Glu Asn Asn Pro His Leu Asp Arg Leu Lys Glu210 215 220ttg gcg gca aaa gaa aac gcc ccc gtc gtc gcc gtt tgc gcc gcg atg720Leu Ala Ala Lys Glu Asn Ala Pro Val Val Ala Val Cys Ala Ala Met225 230 235 240gag agc gaa att gcc gaa ttg gaa gac gac gaa aaa gcc gag ttc ctc768Glu Ser Glu Ile Ala Glu Leu Glu Asp Asp Glu Lys Ala Glu Phe Leu245 250 255gcc gaa atg ggc ttg gaa gaa ccg ggc ctg aac cgc ctg att cgt gcc816Ala Glu Met Gly Leu Glu Glu Pro Gly Leu Asn Arg Leu Ile Arg Ala260 265 270ggt tac gac ctc ttg ggg ctg caa acc tat ttc acc gcc ggt gtg aaa864Gly Tyr Asp Leu Leu Gly Leu Gln Thr Tyr Phe Thr Ala Gly Val Lys275 280 285gaa gtc cgc gcg tgg acg ata cac aaa ggc gat acc gcc ccg caa gcc912Glu Val Arg Ala Trp Thr Ile His Lys Gly Asp Thr Ala Pro Gln Ala290 295 300gcc ggc gtg att cac acc gac ttt gag cgc ggc ttc atc cgc gcc caa960Ala Gly Val Ile His Thr Asp Phe Glu Arg Gly Phe Ile Arg Ala Gln305 310 315 320gtc att tct tac gac gac ttt gtc tcg ctc ggc ggc gaa gcc aaa gcc1008Val Ile Ser Tyr Asp Asp Phe Val Ser Leu Gly Gly Glu Ala Lys Ala325 330 335aaa gaa gcc ggc aaa atg cgt gtg gaa ggt aag gaa tac gtc gtg cag1056Lys Glu Ala Gly Lys Met Arg Val Glu Gly Lys Glu Tyr Val Val Gln340 345 350gac ggc gat gta atg cac ttt ttg ttt aac gtg1089Asp Gly Asp Val Met His Phe Leu Phe Asn Val355 360<210>104<211>363<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)
<400>104Met Ser Leu Lys Cys Gly Ile Val Gly Leu Pro Asn Val Gly Lys Ser1 5 10 15Thr Leu Phe Asn Ala Leu Thr Gln Ser Gly Ile Glu Ala Ala Asn Tyr20 25 30Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val Glu Val Pro Asp35 40 45Pro Arg Met Ala Glu Leu Ala Lys Ile Val Asn Pro Gln Lys Met Gln50 55 60Pro Ala Ile Val Glu Phe Val Asp Ile Ala Gly Leu Val Ala Gly Ala65 70 75 80Ser Lys Gly Glu Gly Leu Gly Asn Gln Phe Leu Ala Asn Ile Arg Glu85 90 95Thr Asp Ala Ile Val Asn Val Val Arg Cys Phe Asp Asp Asp Asn Ile100 105 110Val His Val Ala Gly Arg Val Asp Pro Ile Ala Asp Ile Glu Thr Ile115 120 125Gly Thr Glu Leu Ala Leu Ala Asp Leu Ala Ser Val Glu Lys Ala Ile130 135 140Val Arg Glu Glu Lys Arg Ala Arg Ser Gly Asp Lys Asp Ala Gln Lys145 150 155 160Leu Val Asp Leu Cys Lys Lys Leu Leu Pro His Leu Asp Glu Gly Lys165 170 175Pro Val Arg Ser Phe Gly Leu Asp Ala Glu Glu Arg Ala Met Leu Lys180 185 190Pro Leu Phe Leu Leu Thr Ala Lys Pro Ala Met Tyr Val Gly Asn Val195 200 205Ala Glu Asp Gly Phe Glu Asn Asn Pro His Leu Asp Arg Leu Lys Glu210 215 220Leu Ala Ala Lys Glu Asn Ala Pro Val Val Ala Val Cys Ala Ala Met225 230 235 240Glu Ser Glu Ile Ala Glu Leu Glu Asp Asp Glu Lys Ala Glu Phe Leu
245 250 255Ala Glu Met Gly Leu Glu Glu Pro Gly Leu Asn Arg Leu Ile Arg Ala260 265 270Gly Tyr Asp Leu Leu Gly Leu Gln Thr Tyr Phe Thr Ala Gly Val Lys275 280 285Glu Val Arg Ala Trp Thr Ile His Lys Gly Asp Thr Ala Pro Gln Ala290 295 300Ala Gly Val Ile His Thr Asp Phe Glu Arg Gly Phe Ile Arg Ala Gln305 310 315 320Val Ile Ser Tyr Asp Asp Phe Val Ser Leu Gly Gly Glu Ala Lys Ala325 330 335Lys Glu Ala Gly Lys Met Arg Val Glu Gly Lys Glu Tyr Val Val Gln340 345 350Asp Gly Asp Val Met His Phe Leu Phe Asn Val355 360<210>105<211>1177<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1176)<400>105atg gca aaa atg atg aaa tgg gcg gct gtt gcg gcg gtc gcg gcg gca48Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala1 5 10 15gcg gtt tgg ggc gga tgg tct tat ctg aag ccc gag ccg cag gct gct96Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala20 25 30tat att acg gaa acg gtc agg cgc ggc gac atc agc cgg acg gtt tct144Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser35 40 45gca aca ggg gag att tcg ccg tcc aac ctg gta tcg gtc ggc gcg cag192
Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln50 55 60gca tcg ggg cag att aag aaa ctt tat gtc aaa ctc ggg caa cag gtt240Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val65 70 75 80aaa aag ggc gat ttg att gcg gaa atc aat tcg acc tcg cag acc aat288Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn85 90 95acg ctc aat acg gaa aaa tcc aaa ttg gaa acg tat cag gcg aag ctg336Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu100 105 110gtg tcg gca cag att gca ttg ggc agc gcg gag aag aaa tat aag cgt384Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg115 120 125cag gcg gcg ttg tgg aag gat gat gcg acc gct aaa gaa gat ttg gaa432Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu130 135 140agc gca cag gat gcg ctt gcc gcc gcc aaa gcc aat gtt gcc gag ctg480Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu145 150 155 160aag gct cta atc aga cag agc aaa att tcc atc aat acc gcc gag tcg528Lys Ala Leu Ile Arg Gln Ser Lys Ile Set Ile Asn Thr Ala Glu Ser165 170 175gaa ttg ggc tac acg cgc att acc gca acg atg gac ggc acg gtg gtg576Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val180 185 190gcg att ctc gtg gaa gag ggg cag act gtg aac gcg gcg cag tct acg624Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr195 200 205ccg acg att gtc caa ttg gcg aat ctg gat atg atg ttg aac aaa atg672Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met210 215 220cag att gcc gag ggc gat att acc aag gtg aag gcg ggg cag gat att720Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile225 230 235 240tcg ttt acg att ttg tcc gaa ccg gat acg ccg att aag gcg aag ctc768
Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu245 250 255gac agc gtc gac ccc ggg ctg acc acg atg tcg tcg ggc ggc tac aac 816Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn260 265 270agc agt acg gat acg gct tcc aat gcg gtc tac tat tat gcc cgt tcg 864Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser275 280 285ttt gtg ccg aat ccg gac ggc aaa ctc gcc acg ggg atg acg acg cag 912Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln290 295 300aat acg gtt gaa atc gac ggt gtg aaa aat gtg ctg att att ccg tcg 960Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser305 310 315 320ctg acc gtg aaa aat egc ggc ggc agg gcg ttt gtg cgc gtg ttg ggt 1008Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arg Val Leu Gly325 330 335gca gac ggc aag gcg gcg gaa egc gaa atc egg acc ggt atg aga gac 1056Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp340 345 350agt atg aat acc gaa gta aaa agc ggg ttg aaa gag ggg gac aaa gtg 1104Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val355 360 365gtc atc tcc gaa ata acc gcc gcc gag cag cag gaa agc ggc gaa cgc 1152Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg370 375 380gcc cta ggc ggc ccg ccg cgc cga t1177Ala Leu Gly Gly Pro Pro Arg Arg385 390<210>106<211>392<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>106Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala1 5 10 15
Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala20 25 30Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser35 40 45Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln50 55 60Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val65 70 75 80Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn85 90 95Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu100 105 110Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg115 120 125Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu130 135 140Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu145 150 155 160Lys Ala Leu Ile Arg Gln Ser Lys Ile Ser Ile Asn Thr Ala Glu Ser165 170 175Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val180 185 190Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr195 200 205Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met210 215 220Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile225 230 235 240Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu245 250 255Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn260 265 270
Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser275 280 285Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln290 295 300Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser305 310 315 320Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arg Val Leu Gly325 330 335Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp340 345 350Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val355 360 365Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg370 375 380Ala Leu Gly Gly Pro Pro Arg Arg385 390<210>107<211>1185<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1185)<400>107atg aca gag gac gaa cgt ttc gcg tgg ctg caa ttg gcg ttt acg ccc48Met Thr Glu Asp Glu Arg Phe Ala Trp Leu Gln Leu Ala Phe Thr Pro1 5 10 15tat atc ggc gcg gaa agt ttc ctg ctg ctg atg cgc cgt ttc ggc agc96Tyr Ile Gly Ala Glu Ser Phe Leu Leu Leu Met Arg Arg Phe Gly Ser20 25 30gcg caa aat gcc ctg tcc gca ccg gcg gaa cag gtg gcg gca ctg ata144Ala Gln Asn Ala Leu Ser Ala Pro Ala Glu Gln Val Ala Ala Leu Ile35 40 45
cgg cac aaa cag gcg ctt gag gct tgg cgc aat gcg gaa aaa cgc gct192Arg His Lys Gln Ala Leu Glu Ala Trp Arg Asn Ala Glu Lys Arg Ala50 55 60ctg gcg cgg cag gcg gca gaa gcg gcg ttg gaa tgg gaa atg cgg gac240Leu Ala Arg Gln Ala Ala Glu Ala Ala Leu Glu Trp Glu Met Arg Asp65 70 75 80gga tgc cgc ctg atg ctg ctt cag gat gaa gat ttc ccc gaa atg ctg288Gly Cys Arg Leu Met Leu Leu Gln Asp Glu Asp Phe Pro Glu Met Leu85 90 95acg cag ggg ctg acc gcg ccg ccg gtt ttg ttt ttg cgc ggc aac gtg336Thr Gln Gly Leu Thr Ala Pro Pro Val Leu Phe Leu Arg Gly Asn Val100 105 110cgg ctg ctg cac aag cct tcc gcc gcc atc gtc ggc agc cgc cat gcc384Arg Leu Leu His Lys Pro Ser Ala Ala Ile Val Gly Ser Arg His Ala115 120 125acg ccg cag gcg atg cgg att gcc aaa gat ttc ggc aag tcg ttg ggc432Thr Pro Gln Ala Met Arg Ile Ala Lys Asp Phe Gly Lys Ser Leu Gly130 135 140ggg caa aat atc ccc gtt gtg tcg ggt atg gct tcc ggt atc gat act480Gly Gln Asn Ile Pro Val Val Ser Gly Met Ala Ser Gly Ile Asp Thr145 150 155 160gcc gcc cat cag ggc gca ctg gag gca gaa ggc ggc acc atc gcc gtg528Ala Ala His Gln Gly Ala Leu Glu Ala Glu Gly Gly Thr Ile Ala Val165 170 175tgg ggg acg ggt ata gac cgc att tac ccg ccg tcc aat aaa aac ctt576Trp Gly Thr Gly Ile Asp Arg Ile Tyr Pro Pro Ser Asn Lys Asn Leu180 185 190gcc tat gaa atc gcc gaa aaa gga ttg att gtc agc gag ttt ccc atc624Ala Tyr Glu Ile Ala Glu Lys Gly Leu Ile Val Ser Glu Phe Pro Ile195 200 205ggt acg cgc ccg tat gcc ggc aat ttt ccg cgc cgc aac cgc ctg att672Gly Thr Arg Pro Tyr Ala Gly Asn Phe Pro Arg Arg Asn Arg Leu Ile210 215 220gcc gcc ctg tcg caa gta acg ctg gtg gtt gaa gcc gcc ttg gaa tcc720Ala Ala Leu Ser Gln Val Thr Leu Val Val Glu Ala Ala Leu Glu Ser225 230 235 240
ggt tcg ctg att acc gcc ggc ctg gcg gca gaa atg ggg cgc gaa gtg768Gly Ser Leu Ile Thr Ala Gly Leu Ala Ala Glu Met Gly Arg Glu Val245 250 255atg gcg gta ccc ggt tcg ata gac aat ccg cac agc aaa ggc tgc cac816Met Ala Val Pro Gly Ser Ile Asp Asn Pro His Ser Lys Gly Cys His260 265 270aaa ctg att aaa gac ggc gca aaa ttg gtg gaa tgc ctg gac gac atc864Lys Leu Ile Lys Asp Gly Ala Lys Leu Val Glu Cys Leu Asp Asp Ile275 280 285ctg aac gaa tgc ccg ggg cta ttg caa aat acg ggt gct tca tca tat912Leu Asn Glu Cys Pro Gly Leu Leu Gln Asn Thr Gly Ala Ser Ser Tyr290 295 300tct ata aat aag gat acg ccc gac acg gga cgc cgc gcc gtt cag acg960Ser Ile Asn Lys Asp Thr Pro Asp Thr Gly Arg Arg Ala Val Gln Thr305 310 315 320gca tac gcc ccg ccg cct gcc gca aaa atg ccg tct gaa gcg gcg gca1008Ala Tyr Ala Pro Pro Pro Ala Ala Lys Met Pro Ser Glu Ala Ala Ala325 330 335ggc ggc aca gcc gtc ggc ggc ata ctg gat aaa atg ggt ttc gac ccc1056Gly Gly Thr Ala Val Gly Gly Ile Leu Asp Lys Met Gly Phe Asp Pro340 345 350atc cat ccc gac gtg ctt gcc gga cag ttg gct atg cct gcc gca gat1104Ile His Pro Asp Val Leu Ala Gly Gln Leu Ala Met Pro Ala Ala Asp355 360 365ttg tat gcc gca ctg ttg gaa ttg gaa ttg gac ggc agc gtt gcc gca1152Leu Tyr Ala Ala Leu Leu Glu Leu Glu Leu Asp Gly Ser Val Ala Ala370 375 380atg ccc agc ggc aga tac cag cgt atc cga act1185Met Pro Ser Gly Arg Tyr Gln Arg Ile Arg Thr385 390 395<210>108<211>395<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>108
Met Thr Glu Asp Glu Arg Phe Ala Trp Leu Gln Leu Ala Phe Thr Pro1 5 10 15Tyr Ile Gly Ala Glu Ser Phe Leu Leu Leu Met Arg Arg Phe Gly Ser20 25 30Ala Gln Asn Ala Leu Ser Ala Pro Ala Glu Gln Val Ala Ala Leu Ile35 40 45Arg His Lys Gln Ala Leu Glu Ala Trp Arg Asn Ala Glu Lys Arg Ala50 55 60Leu Ala Arg Gln Ala Ala Glu Ala Ala Leu Glu Trp Glu Met Arg Asp65 70 75 80Gly Cys Arg Leu Met Leu Leu Gln Asp Glu Asp Phe Pro Glu Met Leu85 90 95Thr Gln Gly Leu Thr Ala Pro Pro Val Leu Phe Leu Arg Gly Asn Val100 105 110Arg Leu Leu His Lys Pro Ser Ala Ala Ile Val Gly Ser Arg His Ala115 120 125Thr Pro Gln Ala Met Arg Ile Ala Lys Asp Phe Gly Lys Ser Leu Gly130 135 140Gly Gln Asn Ile Pro Val Val Ser Gly Met Ala Ser Gly Ile Asp Thr145 150 155 160Ala Ala His Gln Gly Ala Leu Glu Ala Glu Gly Gly Thr Ile Ala Val165 170 175Trp Gly Thr Gly Ile Asp Arg Ile Tyr Pro Pro Ser Asn Lys Asn Leu180 185 190Ala Tyr Glu Ile Ala Glu Lys Gly Leu Ile Val Ser Glu Phe Pro Ile195 200 205Gly Thr Arg Pro Tyr Ala Gly Asn Phe Pro Arg Arg Asn Arg Leu Ile210 215 220Ala Ala Leu Ser Gln Val Thr Leu Val Val Glu Ala Ala Leu Glu Ser225 230 235 240Gly Ser Leu Ile Thr Ala Gly Leu Ala Ala Glu Met Gly Arg Glu Val245 250 255
Met Ala Val Pro Gly Ser Ile Asp Asn Pro His Ser Lys Gly Cys His260 265 270Lys Leu Ile Lys Asp Gly Ala Lys Leu Val Glu Cys Leu Asp Asp Ile275 280 285Leu Asn Glu Cys Pro Gly Leu Leu Gln Asn Thr Gly Ala Ser Ser Tyr290 295 300Ser Ile Asn Lys Asp Thr Pro Asp Thr Gly Arg Arg Ala Val Gln Thr305 310 315 320Ala Tyr Ala Pro Pro Pro Ala Ala Lys Met Pro Ser Glu Ala Ala Ala325 330 335Gly Gly Thr Ala Val Gly Gly Ile Leu Asp Lys Met Gly Phe Asp Pro340 345 350Ile His Pro Asp Val Leu Ala Gly Gln Leu Ala Met Pro Ala Ala Asp355 360 365Leu Tyr Ala Ala Leu Leu Glu Leu Glu Leu Asp Gly Ser Val Ala Ala370 375 380Met Pro Ser Gly Arg Tyr Gln Arg Ile Arg Thr385 390 395<210>109<211>1257<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1257)<400>109atg aaa cag acc gtc ctc aaa aat aac ctg caa aac ctg ctt gaa agc48Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser1 5 10 15gca gaa aat atc ctg ctg ctt caa ggc cct gtc ggc gat ttt ttt ctg96Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu20 25 30cgc ctt gcc gac tgg ctg act gca aac ggc aaa acc gta cat aaa ttc144
Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe35 40 45aac ttt aat gca ggc gac gac tat ttt tat ccg ccc act caa gcg cat 192Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His50 55 60acc gtt gtt ttt aac gac aac tac gat gcc ttt cct gag ttt ttg caa240Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln65 70 75 80gaa tac atc act caa cat cac atc cag gcc gtt gtc tgc ttt ggc gac288Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp85 90 95aca cgc cct tat cac gtc att gca aaa cgc att gca aac gaa aac caa336Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln100 105 110gcc agt ttc tgg gcg ttt gaa gaa ggc tat ttc cgc ccc tac tac atc384Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile115 120 125acc tta gaa aaa gac ggc gtc aac gca ttt tcc ccg ttg ccg cgc cgt432Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg130 135 140gcc gac ttt ttt ctt gaa caa ttc cct aag ctt gcc cag caa gaa tat480Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr145 150 155 160aaa gcg cca acg ccg gta cac ggc ggt ttt acg ccc atg gca aaa aac528Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn165 170 175gct atc cgt tac tat atc gag ttg ttc cgc aat cta cgc aaa tac ccc576Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Ash Leu Arg Lys Tyr Pro180 185 190gac tac atc cac cac cgc gca ccc aat gcc ggc cat tac ctc aaa ccg624Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro195 200 205tgg tcg ctc tcc atc ctc aag cgt ttg aac tac tat att gaa gac atc672Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile210 215 220caa atc gcc aaa cgt gtg gaa gca ggc aaa tac ggc aag ttt ttt att720
Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile225 230 235 240gtt ccc ttg cag gta ttc aac gac agc caa gtc cgt atc cat tgc gac768Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp245 250 255ttt ccc agc gtc cgc agc ttc ctg ctc cat gtt ttg agt tca ttt gcc816Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala260 265 270gaa cac gcg cct gcc gat acc aac atc atc atc aag cat cat cct atg864Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met275 280 285gac cgc ggc ttt atc gac tac tgg cgc gac att aaa cgc ttt atc aaa912Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys290 295 300gaa cac ccc gaa ctc aaa ggc cgt gtg att tat gtc cat gat gtc ccc960Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro305 310 315 320ctg ccc gtt ttc ctg cgc cac ggt ctc ggc atg gtt acc atc aac agc1008Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser325 330 335acc agc ggc ctg tcc gga ctg att cac aat atg cca gtt aag gtt ctc1056Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu340 345 350ggc cgt gcc tat tat gat att ccc ggc att act gac caa aat acc ttg1104Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu355 360 365gca gaa ttt tgg aat cat ccg aca ccg cct gac aaa gag ctg ttc cat1152Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His370 375 380gcc tac cga atg tac cac ctc aac gtg acc caa att aac ggc aac ttc1200Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe385 390 395 400tac agt cag gtc ttt ttt cct aac aaa aac aca tcc gac tct tcc aca1248Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr405 410 415cca aca acc1257
Pro Thr Thr<210>110<211>419<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>110Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser1 5 10 15Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu20 25 30Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe35 40 45Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His50 55 60Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln65 70 75 80Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp85 90 95Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln100 105 110Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile115 120 125Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg130 135 140Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr145 150 155 160Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn165 170 175Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Asn Leu Arg Lys Tyr Pro180 185 190Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro195 200 205
Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile210 215 220Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile225 230 235 240Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp245 250 255Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala260 265 270Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met275 280 285Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys290 295 300Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro305 310 315 320Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser325 330 335Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu340 345 350Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu355 360 365Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His370 375 380Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe385 390 395 400Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr405 410 415Pro Thr Thr<210>111<211>1674<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)
<220>
<221>CDS<222>(1)..(1674)<400>111atg agt ttc aaa acc gat gcc gaa atc gcc caa tcc tcc acc atg cgc48Met Ser Phe Lys Thr Asp Ala Glu Ile Ala Gln Ser Ser Thr Met Arg1 5 10 15ccg att ggc gaa att gcc gcc aag ctg ggt ttg aac gtt gac aac att96Pro Ile Gly Glu Ile Ala Ala Lys Leu Gly Leu Asn Val Asp Asn Ile20 25 30gag cct tac ggt cat tac aaa gcc aaa atc aat cct gcc gaa gcg ttc144Glu Pro Tyr Gly His Tyr Lys Ala Lys Ile Asn Pro Ala Glu Ala Phe35 40 45aaa ctg ccg caa aaa cag ggc agg ctg att ttg gtt acc gcc atc aac192Lys Leu Pro Gln Lys Gln Gly Arg Leu Ile Leu Val Thr Ala Ile Asn50 55 60ccg act ccg gcg ggc gaa ggt aaa acc acc gta acc atc ggt ttg gcg240Pro Thr Pro Ala Gly Glu Gly Lys Thr Thr Val Thr Ile Gly Leu Ala65 70 75 80gac gca ttg cgc cat atc ggc aaa gac tct gtg att gct ttg cgc gag288Asp Ala Leu Arg His Ile Gly Lys Asp Ser Val Ile Ala Leu Arg Glu85 90 95cct tct ttg ggt ccg gtg ttc ggc gtg aaa ggc ggc gcg gca ggc ggc336Pro Ser Leu Gly Pro Val Phe Gly Val Lys Gly Gly Ala Ala Gly Gly100 105 110ggc tat gcc caa gtt ttg ccg atg gaa gac atc aac ctg cac ttc acc384Gly Tyr Ala Gln Val Leu Pro Met Glu Asp Ile Asn Leu His Phe Thr115 120 125gga gat ttt cac gcc atc ggt gcg gca aat aat ctg ctt gcc gcg atg432Gly Asp Phe His Ala Ile Gly Ala Ala Asn Asn Leu Leu Ala Ala Met130 135 140ctc gac aac cat atc tac caa ggc aac gag ttg aac atc gac ccc aaa480Leu Asp Asn His Ile Tyr Gln Gly Asn Glu Leu Asn Ile Asp Pro Lys145 150 155 160cgc gtg ctg tgg cgg cgc gtg gtc gat atg aac gac cgc cag ttg cgc528Arg Val Leu Trp Arg Arg Val Val Asp Met Asn Asp Arg Gln Leu Arg
165 170 175aac atc atc gac ggc atg ggc aag cct gtt gac ggc gtg atg cgt cct576Asn Ile Ile Asp Gly Met Gly Lys Pro Val Asp Gly Val Met Arg Pro180 185 190gac ggt ttc gat att acc gtt gct tcc gaa gtg atg gcg gta ttc tgt624Asp Gly Phe Asp Ile Thr Val Ala Ser Glu Val Met Ala Val Phe Cys195 200 205ctt gcc aaa gac atc agc gat ttg aaa gag cgt ttg ggc aac atc ctt672Leu Ala Lys Asp Ile Ser Asp Leu Lys Glu Arg Leu Gly Asn Ile Leu210 215 220gtc gcc tac gcc aaa gac ggc agc ccc gtt tac gcc aaa gat ttg aaa720Val Ala Tyr Ala Lys Asp Gly Ser Pro Val Tyr Ala Lys Asp Leu Lys225 230 235 240gcg aat ggc gcg atg gcg gca ttg ctt aaa gat gcg att aag ccc aac768Ala Asn Gly Ala Met Ala Ala Leu Leu Lys Asp Ala Ile Lys Pro Asn245 250 255ttg gtg caa acc atc gaa ggc acg ccc gcc ttc gta cac ggc ggc ccg816Leu Val Gln Thr Ile Glu Gly Thr Pro Ala Phe Val His Gly Gly Pro260 265 270ttc gcc aac atc gcc cac ggc tgc aac tcc gta acc gca acc cgt ctg864Phe Ala Asn Ile Ala His Gly Cys Asn Ser Val Thr Ala Thr Arg Leu275 280 285gcg aaa cac ctt gcc gat tac gcc gta acc gaa gca ggc ttc ggc gcg912Ala Lys His Leu Ala Asp Tyr Ala Val Thr Glu Ala Gly Phe Gly Ala290 295 300gac ttg ggc gcg gaa aaa ttc tgc gac atc aaa tgc cgc ctt gcc ggt960Asp Leu Gly Ala Glu Lys Phe Cys Asp Ile Lys Cys Arg Leu Ala Gly305 310 315 320ttg aaa cct gat gcg gct gtt gtc gtg gcg act gtc cgc gcg ttg aaa1008Leu Lys Pro Asp Ala Ala Val Val Val Ala Thr Val Arg Ala Leu Lys325 330 335tat aac ggc ggc gtg gaa cgc gcc aac ctc ggc gaa gaa aat tta gac1056Tyr Asn Gly Gly Val Glu Arg Ala Asn Leu Gly Glu Glu Asn Leu Asp340 345 350gct ttg gaa aaa ggt ttg ccc aac ctg ctg aaa cac att tcc aac ctg1104Ala Leu Glu Lys Gly Leu Pro Asn Leu Leu Lys His Ile Ser Asn Leu
355 360 365aaa aac gta ttc gga ctg ccc gtc gtc gtt gcg ctc aac cgc ttc gtg1152Lys Asn Val Phe Gly Leu Pro Val Val Val Ala Leu Asn Arg Phe Val370 375 380tcc gac tcc gat gcc gag ttg gcg atg att gaa aaa gcc tgt gcc gaa1200Ser Asp Ser Asp Ala Glu Leu Ala Met Ile Glu Lys Ala Cys Ala Glu385 390 395 400cac ggc gtt gaa gtt tcc ctg acc gaa gtg tgg ggc aaa ggt ggt gcg1248His Gly Val Glu Val Ser Leu Thr Glu Val Trp Gly Lys Gly Gly Ala405 410 415ggc ggc gcg gat ttg gcg cgc aaa gtc gtc aac gcc att gaa agt caa1296Gly Gly Ala Asp Leu Ala Arg Lys Val Val Asn Ala Ile Glu Ser Gln420 425 430acc aat aac ttc ggt ttc gcc tac gat gtc gag ttg ggc atc aaa gac1344Thr Asn Asn Phe Gly Phe Ala Tyr Asp Val Glu Leu Gly Ile Lys Asp435 440 445aaa atc cgt gcg att gcc caa aaa gtg tac ggc gcg gaa gat gtt gat1392Lys Ile Arg Ala Ile Ala Gln Lys Val Tyr Gly Ala Glu Asp Val Asp450 455 460ttc agc gcg gaa gcg tct gcc gaa atc gct tca ctg gaa aaa ctg ggc1440Phe Ser Ala Glu Ala Ser Ala Glu Ile Ala Ser Leu Glu Lys Leu Gly465 470 475 480ttg gac aaa atg ccg atc tgc atg gcg aaa acc caa tac tct ttg agc1488Leu Asp Lys Met Pro Ile Cys Met Ala Lys Thr Gln Tyr Ser Leu Ser485 490 495gac aac gcc aaa ctg ttg ggc tgc ccc gaa gac ttc cgc atc gcc gtg1536Asp Asn Ala Lys Leu Leu Gly Cys Pro Glu Asp Phe Arg Ile Ala Val500 505 510cgc ggc atc acc gtt tcc gca ggc gca ggt ttc atc gtc gcc ctg tgc1584Arg Gly Ile Thr Val Ser Ala Gly Ala Gly Phe Ile Val Ala Leu Cys515 520 525ggc aac atg atg aaa atg ccc ggc ctg ccc aaa gtt ccg gct gcc gag1632Gly Asn Met Met Lys Met Pro Gly Leu Pro Lys Val Pro Ala Ala Glu530 535 540aaa atc gat gtg gac gca gaa ggc gtg att cac ggc ttg ttc1674Lys Ile Asp Val Asp Ala Glu Gly Val Ile His Gly Leu Phe
545 550 555<210>112<211>558<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>112Met Ser Phe Lys Thr Asp Ala Glu Ile Ala Gln Ser Ser Thr Met Arg1 5 10 15Pro Ile Gly Glu Ile Ala Ala Lys Leu Gly Leu Asn Val Asp Asn Ile20 25 30Glu Pro Tyr Gly His Tyr Lys Ala Lys Ile Asn Pro Ala Glu Ala Phe35 40 45Lys Leu Pro Gln Lys Gln Gly Arg Leu Ile Leu Val Thr Ala Ile Asn50 55 60Pro Thr Pro Ala Gly Glu Gly Lys Thr Thr Val Thr Ile Gly Leu Ala65 70 75 80Asp Ala Leu Arg His Ile Gly Lys Asp Ser Val Ile Ala Leu Arg Glu85 90 95Pro Ser Leu Gly Pro Val Phe Gly Val Lys Gly Gly Ala Ala Gly Gly100 105 110Gly Tyr Ala Gln Val Leu Pro Met Glu Asp Ile Asn Leu His Phe Thr115 120 125Gly Asp Phe His Ala Ile Gly Ala Ala Asn Asn Leu Leu Ala Ala Met130 135 140Leu Asp Asn His Ile Tyr Gln Gly Asn Glu Leu Asn Ile Asp Pro Lys145 150 155 160Arg Val Leu Trp Arg Arg Val Val Asp Met Asn Asp Arg Gln Leu Arg165 170 175Asn Ile Ile Asp Gly Met Gly Lys Pro Val Asp Gly Val Met Arg Pro180 185 190Asp Gly Phe Asp Ile Thr Val Ala Ser Glu Val Met Ala Val Phe Cys195 200 205
Leu Ala Lys Asp Ile Ser Asp Leu Lys Glu Arg Leu Gly Asn Ile Leu210 215 220Val Ala Tyr Ala Lys Asp Gly Ser Pro Val Tyr Ala Lys Asp Leu Lys225 230 235 240Ala Asn Gly Ala Met Ala Ala Leu Leu Lys Asp Ala Ile Lys Pro Asn245 250 255Leu Val Gln Thr Ile Glu Gly Thr Pro Ala Phe Val His Gly Gly Pro260 265 270Phe Ala Asn Ile Ala His Gly Cys Asn Ser Val Thr Ala Thr Arg Leu275 280 285Ala Lys His Leu Ala Asp Tyr Ala Val Thr Glu Ala Gly Phe Gly Ala290 295 300Asp Leu Gly Ala Glu Lys Phe Cys Asp Ile Lys Cys Arg Leu Ala Gly305 310 315 320Leu Lys Pro Asp Ala Ala Val Val Val Ala Thr Val Arg Ala Leu Lys325 330 335Tyr Asn Gly Gly Val Glu Arg Ala Asn Leu Gly Glu Glu Asn Leu Asp340 345 350Ala Leu Glu Lys Gly Leu Pro Asn Leu Leu Lys His Ile Ser Asn Leu355 360 365Lys Asn Val Phe Gly Leu Pro Val Val Val Ala Leu Asn Arg Phe Val370 375 380Ser Asp Ser Asp Ala Glu Leu Ala Met Ile Glu Lys Ala Cys Ala Glu385 390 395 400His Gly Val Glu Val Ser Leu Thr Glu Val Trp Gly Lys Gly Gly Ala405 410 415Gly Gly Ala Asp Leu Ala Arg Lys Val Val Asn Ala Ile Glu Ser Gln420 425 430Thr Asn Asn Phe Gly Phe Ala Tyr Asp Val Glu Leu Gly Ile Lys Asp435 440 445Lys Ile Arg Ala Ile Ala Gln Lys Val Tyr Gly Ala Glu Asp Val Asp450 455 460
Phe Ser Ala Glu Ala Ser Ala Glu Ile Ala Ser Leu Glu Lys Leu Gly465 470 475 480Leu Asp Lys Met Pro Ile Cys Met Ala Lys Thr Gln Tyr Ser Leu Ser485 490 495Asp Asn Ala Lys Leu Leu Gly Cys Pro Glu Asp Phe Arg Ile Ala Val500 505 510Arg Gly Ile Thr Val Ser Ala Gly Ala Gly Phe Ile Val Ala Leu Cys515 520 525Gly Asn Met Met Lys Met Pro Gly Leu Pro Lys Val Pro Ala Ala Glu530 535 540Lys Ile Asp Val Asp Ala Glu Gly Val Ile His Gly Leu Phe545 550 555<210>113<211>475<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(474)<400>113atg gaa cac cta ttt gag gaa tgg ttg ccc gac ctg ccc gcc gac gtt48Met Glu His Leu Phe Glu Glu Trp Leu Pro Asp Leu Pro Ala Asp Val1 5 10 15tca gac ggc atc ggc ctg ccg atg agc cgg tta ttg aaa gcc cgg tcg96Ser Asp Gly Ile Gly Leu Pro Met Ser Arg Leu Leu Lys Ala Arg Ser20 25 30ctg act gcc gca ttg cgc gcc ttg ccg cat ctg ttt tcg gta gaa ctg144Leu Thr Ala Ala Leu Arg Ala Leu Pro His Leu Phe Ser Val Glu Leu35 40 45ctg aaa ctg ggc gaa ttg gaa acg gaa tgc gga ggg cgg ctg gtg cgc192Leu Lys Leu Gly Glu Leu Glu Thr Glu Cys Gly Gly Arg Leu Val Arg50 55 60gaa gtt ttg ttg aag ctg gac ggt atc cct gtt gtc gcg gca agg agc240Glu Val Leu Leu Lys Leu Asp Gly Ile Pro Val Val Ala Ala Arg Ser
65 70 75 80gaa tgc cgt atc ggt tcg gcg ttt tgg caa aac att ttg gac tgc ggc288Glu Cys Arg Ile Gly Ser Ala Phe Trp Gln Asn Ile Leu Asp Cys Gly85 90 95acg cgt cct ttg ggc gaa cgt ctg ttt caa gcc gat ttg gaa ggg gcg336Thr Arg Pro Leu Gly Glu Arg Leu Phe Gln Ala Asp Leu Glu Gly Ala100 105 110cgt tcg gcg ttt gag ttt gcc gtt ttc ggc gaa gga tgc gga cgg tac384Arg Ser Ala Phe Glu Phe Ala Val Phe Gly Glu Gly Cys Gly Arg Tyr115 120 125ttt gcc gct cgg cgt tcg cgg ttt tcc cat cac ggc gag gaa atg ctg432Phe Ala Ala Arg Arg Ser Arg Phe Ser His His Gly Glu Glu Met Leu130 135 140ctg acc gag tat ttt ctg ccc gaa ctg aaa cgc ttt atc gga t 475Leu Thr Glu Tyr Phe Leu Pro Glu Leu Lys Arg Phe Ile Gly145 150 155<210>114<211>158<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>114Met Glu His Leu Phe Glu Glu Trp Leu Pro Asp Leu Pro Ala Asp Val1 5 10 15Ser Asp Gly Ile Gly Leu Pro Met Ser Arg Leu Leu Lys Ala Arg Ser20 25 30Leu Thr Ala Ala Leu Arg Ala Leu Pro His Leu Phe Ser Val Glu Leu35 40 45Leu Lys Leu Gly Glu Leu Glu Thr Glu Cys Gly Gly Arg Leu Val Arg50 55 60Glu Val Leu Leu Lys Leu Asp Gly Ile Pro Val Val Ala Ala Arg Ser65 70 75 80Glu cys Arg Ile Gly Ser Ala Phe Trp Gln Asn Ile Leu Asp Cys Gly85 90 95Thr Arg Pro Leu Gly Glu Arg Leu Phe Gln Ala Asp Leu Glu Gly Ala
100 105 110Arg Ser Ala Phe Glu Phe Ala Val Phe Gly Glu Gly Cys Gly Arg Tyr115 120 125Phe Ala Ala Arg Arg Ser Arg Phe Ser His His Gly Glu Glu Met Leu130 135 140Leu Thr Glu Tyr Phe Leu Pro Glu Leu Lys Arg Phe Ile Gly145 150 155<210>115<211>1476<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1476)<400>115atg aaa tac aaa gac ctg cgc gac ttc atc gcc atg ctc gag cag cag48Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln1 5 10 15ggc aaa ctc aaa cgc atc gcg cac ccc gtt tcc ccg cat ttg gaa atg96Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met20 25 30acc gaa atc gcc gac cgc gtg ctg cgc gcc gaa ggg ccg gcg ttg ttg144Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu35 40 45ttt gaa cac cca gtt aag ccc gac ggt acg cgc tat gat tat ccc gtg192Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val50 55 60ttg gca aac ctg ttc ggc acg ccc gaa cgt gtg gcg atg ggc atg ggc240Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly65 70 75 80gcg gac agc gtg tcc aag ctg cgc gaa atc ggg cag acg ctg gcg tat288Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr85 90 95ttg aaa gaa ccc gaa ccg ccc aaa ggc att aaa gac gcg ttt tcc aaa336
Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys100 105 110ctg ccg ctc ttg aaa gac att tgg agc atg gcg ccg aac gtg gtg aaa384Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys115 120 125aat gcg ccg tgt cag gaa atc gta tgg gaa ggc gaa gac gtt gat ttg432Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu130 135 140tat caa ctt ccg att cag cat tgc tgg ccg gaa gac gtt gcg ccg ctg480Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu145 150 155 160gta acg tgg ggc ttg acc gtc acg cgc ggg ccg cac aaa aaa cgc caa528Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln165 170 175aat ctc ggc att tac cgc caa caa tta atc ggc ata aac aag ctg att576Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile180 185 190atg cgc tgg ctg tcg cat cgc ggc ggc gcg ctg gat tat cag gaa ttc624Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe195 200 205cgc aaa ctc aat ccc gat acg ccg tat ccc gtc gcc gtc gtg ctc ggc672Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly210 215 220tgc gac cct gcc acc att ttg ggc gcg gta acg ccc gtt ccc gat acc720Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr225 230 235 240ttg agc gaa tac cag ttt gcc gga ctg ctg cgc ggt tcg cgg acg gaa768Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu245 250 255ctg gtg aaa tgt atc ggc aac gat ttg caa gtg cct gcc cgc gca gaa816Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu260 265 270atc gtg ttg gaa ggc gtc atc cat cca aac gaa acc gcg ttg gaa ggt864Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly275 280 285cca tac ggc gac cac acg ggc tat tac aac gag cag gac cat ttc ccc912
Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro290 295 300gtg ttt acg gtc gaa cgc atc acc atg cgc gaa aac ccg att tac cac960Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His305 310 315 320tct acc tac aca ggc aaa ccg ccc gat gaa ccc gcc gtt ttg ggc gtg1008Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val325 330 335gcg ttg aac gaa gtg ttc gta ccg ctt ttg caa aag cag ttc ccc gaa1056Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu340 345 350atc acc gat ttt tac ctg ccg ccc gaa ggc tgc tcc tac cgc atg gcg1104Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala355 360 365gtg gtg agc atg aaa aaa cag tac gcc gga cac gcc aag cgc gtg atg1152Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met370 375 380atg ggc tgc tgg tcg ttc ctg cgc cag ttt atg tac acc aaa ttc atc1200Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile385 390 395 400att gtg gtg gat gac gat gtg gat gtg cgc gac tgg aaa gaa gtc atc1248Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile405 410 415tgg gcg gta acc acg cgc atg gac ccc gtg cgc gat acc gtt ttg atg1296Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met420 425 430gaa aac acg ccc atc gac tac ctc gac ttc gcc agc ccc gtc agc gga1344Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly435 440 445ctt ggc ggc aaa atg ggt ttg gat gcg acc aac aag tgg ccg ggc gaa1392Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu450 455 460acc gac cgc gaa tgg gga cgg gtg att aaa aaa gac cct gcg gtt acg1440Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr465 470 475 480gct aag att gat gag att tgg gag gaa ttg ggg ttg1476
Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu485 490<210>116<211>492<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>116Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln1 5 10 15Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met20 25 30Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu35 40 45Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val50 55 60Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly65 70 75 80Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr85 90 95Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys100 105 110Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys115 120 125Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu130 135 140Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu145 150 155 160Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln165 170 175Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile180 185 190Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe195 200 205
Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly210 215 220Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr225 230 235 240Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu245 250 255Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu260 265 270Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly275 280 285Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro290 295 300Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His305 310 315 320Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val325 330 335Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu340 345 350Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala355 360 365Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met370 375 380Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile385 390 395 400Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile405 410 415Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met420 425 430Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly435 440 445Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu450 455 460
Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr465 470 475 480Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu485 490<210>117<211>1515<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1515)<400>117atg ttg tat ttc aga tac ggt ttt ttg gtt gtt tgg tgt gcg gca ggt48Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly1 5 10 15gtt tct gcc gcc tat ggg gcg gat gcg ccc gcg att ttg gat gac aag96Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys20 25 30gca ttg ttg cag gtg cag cgg tcg gtg tcg gat aag tgg gcg gaa tcg144Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser35 40 45gat tgg aaa gtt gac aat gat gcc ccg cgc gtg gtt gac ggg gat ttt192Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe50 55 60ttg ttg gcg cat ccg aaa atg ttg gaa cat agt ttg cgc gac gtg ctc240Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu65 70 75 80aac ggc aat cag gcg gat ttg atc gct tcg ttg gcg gat ttg tat gcc288Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala85 90 95aag ctg ccg gat tat gac gcg gtt ttg tac ggc agg gcg cgg gct ttg336Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu100 105 110ctg gcg aaa ttg gcg gga agg ccg gcg gag gcg gtg gcg cgg tat cgg384
Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg115 120 125gaa ctg cac ggg gaa aat gcg gca gac gag cgg att ttg ctg gat ttg432Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu130 135 140gcg gcg gcg gag ttt gac gat ttc cgg ctg aag tcg gca gaa agg cat480Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His145 150 155 160ttt gcc gag gcg gaa aaa ttg gat ttg ccg gcg ccg gtt ttg gaa aat528Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn165 170 175gtg ggg cgt ttt cgg aaa aaa gcg gag ggg ctg acg ggc tgg cgt ttt576Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe180 185 190tcg ggc ggc atc agt ccg gcg gtc aat aga aat gcc aat aat gcc gcg624Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala195 200 205ccg cag tat tgc cgg caa aac gga ggc cgg cag ata tgc agt gtc agc672Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser210 215 220cgg gcg gag cgg gcg gca ggc ttg aat tat gaa atc gag gcg gaa aaa720Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys225 230 235 240ctg acg gcg ttg gca gat aat cat tat ttg ttg ttc cgt tcc aat atc768Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile245 250 255ggc ggc acg agc tat tat ttc agt aaa aaa tca gct tat gac gac ggg816Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly260 265 270ttc ggc aga gcg tat ttg ggt tgg cag tat aaa aat gca cgg cag acg864Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr275 280 285gcg ggg att ttg ccg ttt tat cag gtg cag ttg tcg ggc agc gac ggc912Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly290 295 300ttt gat gcg aaa aca aaa cgg gta aac aac cgc cgc ctg ccg ccg tat960
Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr305 310 315 320atg ctg gcg cac gga gtc ggc gtg cag ttg tcc cat act tac cgc cca1008Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro325 330 335aac ccg gga tgg caa ttt tcg gtc gcg ctg gaa cat tac cgc caa cgc1056Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg340 345 350tac cgc gaa cag gat agg gcg gaa tac aat aac ggt cgg cag gac ggg1104Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly355 360 365ttt tat gtt tcg tcg gca aaa cgt ttg ggc gaa tcg gca act gtg ttc1152Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe370 375 380ggc ggc tgg cag ttt gtg cgg ttt gtg ccg aaa cgc gaa acg gtg ggc1200Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly385 390 395 400ggc gcg gtc aat aat gcc gcc tac cgg cgc aac ggt gtt tat gcc ggc1248Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly405 410 415tgg gcg cag gag tgg cgg cag ttg ggc ggt ttg aac agt cgg gtt tcc1296Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser420 425 430gcg tct tat gcc cgc cgc aac tat aag ggc gtt gcg gct ttc tcg aca1344Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr435 440 445gag gcg caa cgc aac cgc gaa tgg aat gtc tcg ctg gct ttg agc cac1392Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His450 455 460gac aag ttg tcg tac aaa ggt atc gtg ccc gcg ttg aat tat cgt ttc1440Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe465 470 475 480ggc agg acg gaa agt aat gtg ccg tat gcg aaa cgc cgc aac agc gag1488Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu485 490 495gtg ttt gtg tcg gcg gat tgg cgg ttt1515
Val Phe Val Ser Ala Asp Trp Arg Phe500 505<210>118<211>505<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>118Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly1 5 10 15Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys20 25 30Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser35 40 45Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe50 55 60Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu65 70 75 80Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala85 90 95Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu100 105 110Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg115 120 125Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu130 135 140Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His145 150 155 160Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn165 170 175Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe180 185 190Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala195 200 205
Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser210 215 220Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys225 230 235 240Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile245 250 255Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly260 265 270Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr275 280 285Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly290 295 300Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr305 310 315 320Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro325 330 335Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg340 345 350Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly355 360 365Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe370 375 380Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly385 390 395 400Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly405 410 415Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser420 425 430Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr435 440 445Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His450 455 460
Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe465 470 475 480Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu485 490 495Val Phe Val Ser Ala Asp Trp Arg Phe500 505<210>119<211>756<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(756)<400>119atg gaa acg cat tcg ggc tgt ttt ttg cgg aag acg gta atg aaa gac48Met Glu Thr His Ser Gly Cys Phe Leu Arg Lys Thr Val Met Lys Asp1 5 10 15gat gtt ttg aaa cag cag gca cac gcg gcg ata cag aag aaa ctg ggc96Asp Val Leu Lys Gln Gln Ala His Ala Ala Ile Gln Lys Lys Leu Gly20 25 30tac gcg ttc cgc gat att tcg ctt ttg cgg cag gct ttg acg cac agg144Tyr Ala Phe Arg Asp Ile Ser Leu Leu Arg Gln Ala Leu Thr His Arg35 40 45agc cat cat gcg aag cac aac gag cgg ttc gag ttt gtc ggc gat tcg192Ser His His Ala Lys His Asn Glu Arg Phe Glu Phe Val Gly Asp Ser50 55 60att ttg aat tat acg gtg gcg cgg atg ctg ttt gac gcg ttt ccg aag240Ile Leu Asn Tyr Thr Val Ala Arg Met Leu Phe Asp Ala Phe Pro Lys65 70 75 80ttg acc gag ggc gag ttg tcg cgg ttg cgg gca agt ctg gtc aat gag288Leu Thr Glu Gly Glu Leu Ser Arg Leu Arg Ala Ser Leu Val Asn Glu85 90 95ggc gtg ctg gcg gaa atg gcg gcg gaa atg aat gtc ggc gac ggc ctg336Gly Val Leu Ala Glu Met Ala Ala Glu Met Asn Val Gly Asp Gly Leu
100 105 110tac ttg ggg gcg ggc gag ttg aag agc ggc ggc ttc aga cgg cct tcg384Tyr Leu Gly Ala Gly Glu Leu Lys Ser Gly Gly Phe Arg Arg Pro Ser115 120 125ata ctg gcg gac gcg atg gag gcg atg ttt gcg gcg gtc agc ttc gat432Ile Leu Ala Asp Ala Met Glu Ala Met Phe Ala Ala Val Ser Phe Asp130 135 140gcg gat ttc aac acg gcg gaa aag gtg gtg cgc cat ttg ttt gca gaa480Ala Asp Phe Asn Thr Ala Glu Lys Val Val Arg His Leu Phe Ala Glu145 150 155 160cgc gtc cgg cga gtc gat ttc caa aat cag gca aaa gac ggc aaa act528Arg Val Arg Arg Val Asp Phe Gln Asn Gln Ala Lys Asp Gly Lys Thr165 170 175gct ttg cag gag gcg ttg cag gcg cgc cgt ttc gcc ttg ccg aaa tac576Ala Leu Gln Glu Ala Leu Gln Ala Arg Arg Phe Ala Leu Pro Lys Tyr180 185 190cgt atc gaa gag caa atc ggc cat gcc aac gac agt atg ttt gtc att624Arg Ile Glu Glu Gln Ile Gly His Ala Asn Asp Ser Met Phe Val Ile195 200 205tcc tgc gat ttg ggc gaa ctg ggt ttc gtg tgc cgt gcc aaa ggg acg672Ser Cys Asp Leu Gly Glu Leu Gly Phe Val Cys Arg Ala Lys Gly Thr210 215 220agc cgc aag gcg gcg gag cag gaa gcg gcg aaa gag gct ttg aaa tgg720Ser Arg Lys Ala Ala Glu Gln Glu Ala Ala Lys Glu Ala Leu Lys Trp225 230 235 240ctg gaa gag aag ctg ccg ctg aag aag aaa aag aaa756Leu Glu Glu Lys Leu Pro Leu Lys Lys Lys Lys Lys245 250<210>120<211>252<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>120Met Glu Thr His Ser Gly Cys Phe Leu Arg Lys Thr Val Met Lys Asp1 5 10 15
Asp Val Leu Lys Gln Gln Ala His Ala Ala Ile Gln Lys Lys Leu Gly20 25 30Tyr Ala Phe Arg Asp Ile Ser Leu Leu Arg Gln Ala Leu Thr His Arg35 40 45Ser His His Ala Lys His Asn Glu Arg Phe Glu Phe Val Gly Asp Ser50 55 60Ile Leu Asn Tyr Thr Val Ala Arg Met Leu Phe Asp Ala Phe Pro Lys65 70 75 80Leu Thr Glu Gly Glu Leu Ser Arg Leu Arg Ala Ser Leu Val Asn Glu85 90 95Gly Val Leu Ala Glu Met Ala Ala Glu Met Asn Val Gly Asp Gly Leu100 105 110Tyr Leu Gly Ala Gly Glu Leu Lys Ser Gly Gly Phe Arg Arg Pro Ser115 120 125Ile Leu Ala Asp Ala Met Glu Ala Met Phe Ala Ala Val Ser Phe Asp130 135 140Ala Asp Phe Asn Thr Ala Glu Lys Val Val Arg His Leu Phe Ala Glu145 150 155 160Arg Val Arg Arg Val Asp Phe Gln Asn Gln Ala Lys Asp Gly Lys Thr165 170 175Ala Leu Gln Glu Ala Leu Gln Ala Arg Arg Phe Ala Leu Pro Lys Tyr180 185 190Arg Ile Glu Glu Gln Ile Gly His Ala Asn Asp Ser Met Phe Val Ile195 200 205Ser Cys Asp Leu Gly Glu Leu Gly Phe Val Cys Arg Ala Lys Gly Thr210 215 220Ser Arg Lys Ala Ala Glu Gln Glu Ala Ala Lys Glu Ala Leu Lys Trp225 230 235 240Leu Glu Glu Lys Leu Pro Leu Lys Lys Lys Lys Lys245 250<210>121
<211>570<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(570)<400>121atg gac aat cac gcc gaa gca cac tgg caa aac ggc tgg ctt caa agc48Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser1 5 10 15ata cgc cat acc ccg tcg ccc aat ttc agc ccg agg gaa acg ggg gaa96Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu20 25 30acg gtt tcc ctg atc gtg ttg cac aac att tca ctg ccg ccg ttc gaa144Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu35 40 45tac ggc acg gat gct gtg gaa aag ctg ttt gcc aac cgg ctc gac ccc192Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro50 55 60aac gga cat ccg ttc ttc agc ctg ata cac act ttg cgc gta tcc agc240Asn Gly His Pro Phe Phe Ser Leu Ile His Thr Leu Arg Val Ser Ser65 70 75 80cat ttc tta atc aaa cgc gac ggc aaa acg gtg cag ttc gta tca tgc288His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys85 90 95ggc gat atg gcg tac cac gcg ggc gta tcc tcg ttt cgc gga cgg gaa336Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu100 105 110aaa tgc aac gca ttt tcc atc ggc atc gaa ttg gaa ggc tgc gat ttc384Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe115 120 125gaa ccc ttt acc gaa gcg caa tac cgt tcg ctc gaa aca ttg ttg gaa432Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu130 135 140gca ctc tgc cgc cgc tac ccc gtt acc gca gta acc gga cat cag gac480Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp145 150 155 160
atc gcg ccc ggc cgc aaa acc gac ccc ggc cac ttt ttc gac tgg cgg528Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg165 170 175cgg ata cgg gag aaa ggg ttt ccc gta gac aga aat gcc gtc570Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val180 185 190<210>122<211>190<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>122Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser1 5 10 15Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu20 25 30Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu35 40 45Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro50 55 60Asn Gly His Pro Phe Phe Ser Leu Ile His Thr Leu Arg Val Ser Ser65 70 75 80His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys85 90 95Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu100 105 110Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe115 120 125Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu130 135 140Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp145 150 155 160Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg165 170 175
Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val180 185 190<210>123<211>2274<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(2274)<400>123atg aca aca tta cat ttc tca ggc ttc ccg cgt gtc ggt gcc ttc cgc 48Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg1 5 10 15gaa ttg aaa ttc gca caa gaa aaa tac tgg cgc aaa gaa atc agc gag 96Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu20 25 30caa gaa ttg ctg gct gtt gct aaa gac ttg cgc gag aaa aac tgg aaa 144Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys35 40 45cac cag gcc gct gcc aac gcc gat tac gtt gcc gta ggc gat ttc act 192His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr50 55 60ttc tac gac cac atc ctc gac ctg caa gtc gcc acc ggc gcg att ccc 240Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro65 70 75 80gcc cgc ttc ggc ttc gac agc caa aac cta tct ttg gaa caa ttc ttc 288Ala Arg Phe Gly Phe Asp Set Gln Asn Leu Set Leu Glu Gln Phe Phe85 90 95caa ctg gcg cgc ggt aac aaa gac caa ttc gct atc gaa atg acc aaa 336Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys100 105 110tgg ttc gac acc aac tac cac tac ttg gtg cct gaa ttc cac gcc gat 384Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp115 120 125
acc gaa ttt aaa gcc aat gcc aaa cac tac gtt caa cag ctg caa gaa432Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu130 135 140gcc caa gct ttg ggc ctg aaa gcc aaa ccg acc gtt gtg ggt ccg ttg480Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu145 150 155 160act ttc ctg tgg gtc ggt aaa gaa aaa ggc gcc gtt gaa ttc gac cgt528Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg165 170 175ctg agc ctg ttg cct aaa ctg ttg cct gtt tac gtt gaa atc ctg act576Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr180 185 190gct ttg gtt gaa gcc ggt gcc gag tgg att caa atc gac gag cct gct624Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala195 200 205ttg act gtt gac ctg cct aaa gaa tgg gta gaa gca tac aaa gac gtt672Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val210 215 220tac gcc act ttg agc aaa gta agt gcc aaa atc ctg ctg agc act tac720Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr225 230 235 240ttc ggt tct gtt gcc gaa cac gcc gca ttg ttg aaa tcc ctg cct gtt768Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val245 250 255gac ggc ctg cac atc gac ttg gta cgc gct cct gaa caa ctg gat gcg816Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala260 265 270ttc gcc gac tac gac aaa gtt ctg tct gcc ggc gtc att gac ggc cgc864Phe Ala Asp Tyr Aap Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg275 280 285aat att tgg cgc gcc aac ctg aac aaa gtt ttg gaa act gtt gag ctt912Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu290 295 300ctg caa gcc aaa ctg ggc gac cgt ttg tgg att tcc agc tct tgc tcg960Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser305 310 315 320
ctg ctg cac act ccg ttt gac ttg tca gtt gaa gaa aaa ctg aaa gcc1008Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala325 330 335aac aaa ccc gac ctg tac tct tgg ttg gca ttc acc ctg caa aaa acc1056Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr340 345 350caa gaa ttg cgc gtc ctg aaa gcc gca ttg aac gaa ggc cgt gat tct1104Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser355 360 365gtt gcc gaa gaa ctg gct gcc agc caa gct gct gcc gac tcc cgt gcc1152Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala370 375 380aac agc agc gaa atc cac cgt gca gac gtt gcc aaa cgc ctg gcc gat1200Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp385 390 395 400ttg cct gcc aac gca gac caa cgc aaa tcc cca ttt gcc gac cgt atc1248Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile405 410 415aaa gcg caa caa gca tgg ttg aac ctg cct ctg ctg ccg acg acc aac1296Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn420 425 430atc ggt tct ttc ccg caa act acc gaa atc cgc caa gca cgc gca gcc1344Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala435 440 445ttc aaa aaa ggc gaa ctg tct gcc gcc gat tac gaa gcc gcg atg aaa1392Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys450 455 460aaa gaa atc gcc ttg gtg gtt gaa gag caa gaa aaa ctg gac ttg gac1440Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp465 470 475 480gta ctg gta cac ggc gaa gcc gag cgt aac gac atg gtt gaa tac ttc1488Val Lau Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe485 490 495ggc gaa ttg ttg agc ggt ttt gca ttc acc caa tat ggc tgg gta caa1536Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln500 505 510
agc tac ggt tct cgc tgc gtt aaa cca ccg att atc ttc ggt gac gta1584Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val515 520 525agc cgt cct gaa gcc atg acc gta gct tgg tct act tac gca caa agc1632Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser530 535 540ctg acc aaa cgc ccg atg aaa ggt atg ttg acc ggc cct gta acc att1680Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile545 550 555 560ctg caa tgg tct ttc gtc cgc aac gat att cct cgc tct acc gtg tgt1728Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys565 570 575aaa caa atc gca ctg gct ctg aac gac gaa gta ttg gat ctg gaa aaa1776Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys580 585 590gca ggc atc aaa gtc atc caa atc gac gaa cct gcc atc cgc gaa ggc1824Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly595 600 605ctg cct ttg aaa cgt gcc gat tgg gat gcc tac ctg aac tgg gcc ggc1872Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly610 615 620gaa tct ttc cgc ctg tcc tct acc ggt tgc gaa gac agc act caa atc1920Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile625 630 635 640cac acc cat atg tgc tac tct gag ttc aac gac atc ctg cct gcg att1968His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile645 650 655gct gca atg gat gcg gac gtg atc acc atc gag act tca cgt tcc gac2016Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp660 665 670atg gaa ctc ttg acc gcg ttc ggc gaa ttc aaa tac ccg aac gac atc2064Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile675 680 685ggc ccg ggg gtt tac gac atc cac agc ccg cgc gta ccg aca gaa gcc2112Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala690 695 700
gaa gtg gag cac ctg ttg cgc aaa gcc atc gag gtt gta ccg gtt gaa2160Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu705 710 715 720cgt ctg tgg gtt aac ccg gac tgc ggc ctg aaa aca cgc ggc tgg aaa2208Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys725 730 735gaa act ctg gaa caa ctc caa gtg atg atg aac gta acc cac aaa ttg2256Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu740 745 750cgt gcc gaa ttg gcg aaa2274Arg Ala Glu Leu Ala Lys755<210>124<211>758<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>124Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg1 5 10 15Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu20 25 30Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys35 40 45His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr50 55 60Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro65 70 75 80Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe85 90 95Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys100 105 110Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp115 120 125Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu
130 135 140Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu145 150 155 160Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg165 170 175Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr180 185 190Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala195 200 205Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val210 215 220Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr225 230 235 240Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val245 250 255Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala260 265 270Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg275 280 285Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu290 295 300Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser305 310 315 320Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala325 330 335Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr340 345 350Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser355 360 365Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala370 375 380Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp
385 390 395 400Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile405 410 415Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn420 425 430Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala435 440 445Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys450 455 460Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp465 470 475 480Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe485 490 495Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln500 505 510Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val515 520 525Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser530 535 540Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile545 550 555 560Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys565 570 575Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys580 585 590Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly595 600 605Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly610 615 620Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile625 630 635 640His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile
645 650 655Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp660 665 670Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile675 680 685Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala690 695 700Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu705 710 715 720Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys725 730 735Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu740 745 750Arg Ala Glu Leu Ala Lys755<210>125<211>1137<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1137)<400>125atg agc cgt tta tgg ttt ttt gcc gca aaa aac att ata atc cgc ctt48Met Ser Arg Leu Trp Phe Phe Ala Ala Lys Asn Ile Ile Ile Arg Leu1 5 10 15att tac cta ttg ccc aag gag aca caa atg gca ctc gta tcc atg cgc96Ile Tyr Leu Leu Pro Lys Glu Thr Gln Met Ala Leu Val Ser Met Arg20 25 30caa ctg ctt gat cat gct gcc gaa aac agc tac ggc ctg ccc gcg ttc144Gln Leu Leu Asp His Ala Ala Glu Asn Ser Tyr Gly Leu Pro Ala Phe35 40 45aac gtc aac aac ctc gaa caa atg cgc gcc att atg gaa gcc gcc gac192
Asn Val Asn Asn Leu Glu Gln Met Arg Ala Ile Met Glu Ala Ala Asp50 55 60caa gtc aac gcg ccc gtc atc gta cag gcg agc gca ggt gcg cgc aaa240Gln Val Asn Ala Pro Val Ile Val Gln Ala Ser Ala Gly Ala Arg Lys65 70 75 80tac gcg ggc gcg ccg ttt ttg cgc cac ctg att ttg gcg gct gtc gaa288Tyr Ala Gly Ala Pro Phe Leu Arg His Leu Ile Leu Ala Ala Val Glu85 90 95gaa ttt ccg cac atc ccc gtc gtg atg cac caa gac cac ggc gca tcg336Glu Phe Pro His Ile Pro Val Val Met His Gln Asp His Gly Ala Ser100 105 110ccc gac gtg tgc caa cgc tcc atc caa ctg ggc ttt tcc tcc gtg atg384Pro Asp Val Cys Gln Arg Ser Ile Gln Leu Gly Phe Ser Ser Val Met115 120 125atg gac ggc tcg ctg atg gaa gac ggc aaa acc cct tct tct tat gaa432Met Asp Gly Ser Leu Met Glu Asp Gly Lys Thr Pro Ser Ser Tyr Glu130 135 140tac aac gtc aac gcc acc cgt acc gtg gtt aat ttc tcc cac gcc tgc480Tyr Asn Val Asn Ala Thr Arg Thr Val Val Asn Phe Ser His Ala Cys145 150 155 160ggc gta tcc gtt gaa ggc gaa atc ggc gta ttg ggc aac ctc gaa act528Gly Val Ser Val Glu Gly Glu Ile Gly Val Leu Gly Asn Leu Glu Thr165 170 175ggc gaa gcc ggc gaa gaa gac ggt gta ggc gca gtg ggc aaa ctt tcc576Gly Glu Ala Gly Glu Glu Asp Gly Val Gly Ala Val Gly Lys Leu Ser180 185 190cac gac caa atg ctc acc agc gtc gaa gat gcc gtg cgt ttc gtt aaa624His Asp Gln Met Leu Thr Ser Val Glu Asp Ala Val Arg Phe Val Lys195 200 205gat acc ggc gtt gac gca ttg gcg att gcc gtc ggc acc agc cac ggc672Asp Thr Gly Val Asp Ala Leu Ala Ile Ala Val Gly Thr Ser His Gly210 215 220gcg tac aaa ttc acc cgt ccg ccc aca ggc gac gtg ttg cgt atc gac720Ala Tyr Lys Phe Thr Arg Pro Pro Thr Gly Asp Val Leu Arg Ile Asp225 230 235 240cgc atc aaa gaa atc cac caa gcc ctg ccc aat aca cac atc gtg atg768
Arg Ile Lys Glu Ile His Gln Ala Leu Pro Asn Thr His Ile Val Met245 250 255cac ggc tcc agc tcc gtt ccg caa gaa tgg ctg aaa gtc atc aac gaa816His Gly Ser Ser Ser Val Pro Gln Glu Trp Leu Lys Val Ile Asn Glu260 265 270tac ggc ggc aat atc ggc gaa acc tac ggc gtg ccg gtt gaa gaa atc864Tyr Gly Gly Asn Ile Gly Glu Thr Tyr Gly Val Pro Val Glu Glu Ile275 280 285gtc gaa ggc atc aaa cac ggc gtg cgt aaa gtc aac atc gat acc gac912Val Glu Gly Ile Lys His Gly Val Arg Lys Val Asn Ile Asp Thr Asp290 295 300ttg cgc ctt gct tcc acc ggc gcg gta cgc cgc tac ctt gcc gaa aac960Leu Arg Leu Ala Ser Thr Gly Ala Val Arg Arg Tyr Leu Ala Glu Asn305 310 315 320ccg tcc gac ttc gat ccg cgc aaa tat ttg agc aaa acc att gaa gcg1008Pro Ser Asp Phe Asp Pro Arg Lys Tyr Leu Ser Lys Thr Ile Glu Ala325 330 335atg aag caa atc tgc ctc gac cgc tac ctc gcg ttc ggt tgc gaa ggt1056Met Lys Gln Ile Cys Leu Asp Arg Tyr Leu Ala Phe Gly Cys Glu Gly340 345 350cag gca ggc aaa atc aaa ccg gtt tcc ttg gaa aaa atg gca aac cgt1104Gln Ala Gly Lys Ile Lys Pro Val Ser Leu Glu Lys Met Ala Asn Arg355 360 365tat gcc aag ggc gaa ttg aac caa atc gtc aaa1137Tyr Ala Lys Gly Glu Leu Asn Gln Ile Val Lys370 375<210>126<211>379<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>126Met Ser Arg Leu Trp Phe Phe Ala Ala Lys Asn Ile Ile Ile Arg Leu1 5 10 15Ile Tyr Leu Leu Pro Lys Glu Thr Gln Met Ala Leu Val Ser Met Arg20 25 30
Gln Leu Leu Asp His Ala Ala Glu Asn Ser Tyr Gly Leu Pro Ala Phe35 40 45Asn Val Asn Asn Leu Glu Gln Met Arg Ala Ile Met Glu Ala Ala Asp50 55 60Gln Val Asn Ala Pro Val Ile Val Gln Ala Ser Ala Gly Ala Arg Lys65 70 75 80Tyr Ala Gly Ala Pro Phe Leu Arg His Leu Ile Leu Ala Ala Val Glu85 90 95Glu Phe Pro His Ile Pro Val Val Met His Gln Asp His Gly Ala Ser100 105 110Pro Asp Val Cys Gln Arg Ser Ile Gln Leu Gly Phe Ser Ser Val Met115 120 125Met Asp Gly Ser Leu Met Glu Asp Gly Lys Thr Pro Ser Ser Tyr Glu130 135 140Tyr Asn Val Asn Ala Thr Arg Thr Val Val Asn Phe Ser His Ala Cys145 150 155 160Gly Val Ser Val Glu Gly Glu Ile Gly Val Leu Gly Asn Leu Glu Thr165 170 175Gly Glu Ala Gly Glu Glu Asp Gly Val Gly Ala Val Gly Lys Leu Ser180 185 190His Asp Gln Met Leu Thr Ser Val Glu Asp Ala Val Arg Phe Val Lys195 200 205Asp Thr Gly Val Asp Ala Leu Ala Ile Ala Val Gly Thr Ser His Gly210 215 220Ala Tyr Lys Phe Thr Arg Pro Pro Thr Gly Asp Val Leu Arg Ile Asp225 230 235 240Arg Ile Lys Glu Ile His Gln Ala Leu Pro Asn Thr His Ile Val Met245 250 255His Gly Ser Ser Ser Val Pro Gln Glu Trp Leu Lys Val Ile Asn Glu260 265 270Tyr Gly Gly Asn Ile Gly Glu Thr Tyr Gly Val Pro Val Glu Glu Ile275 280 285
Val Glu Gly Ile Lys His Gly Val Arg Lys Val Asn Ile Asp Thr Asp290 295 300Leu Arg Leu Ala Ser Thr Gly Ala Val Arg Arg Tyr Leu Ala Glu Asn305 310 315 320Pro Ser Asp Phe Asp Pro Arg Lys Tyr Leu Ser Lys Thr Ile Glu Ala325 330 335Met Lys Gln Ile Cys Leu Asp Arg Tyr Leu Ala Phe Gly Cys Glu Gly340 345 350Gln Ala Gly Lys Ile Lys Pro Val Ser Leu Glu Lys Met Ala Asn Arg355 360 365Tyr Ala Lys Gly Glu Leu Asn Gln Ile Val Lys370 375<210>127<211>444<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(444)<400>127gtg gat gct gca gca acg ctc ctg aca tac aaa tgc ccg gcg gaa aac48Val Asp Ala Ala Ala Thr Leu Leu Thr Tyr Lys Cys Pro Ala Glu Asn1 5 10 15cgc cca aac aca aaa aaa att ggt aat ttt tcc tat tca agg cta caa96Arg Pro Asn Thr Lys Lys Ile Gly Asn Phe Ser Tyr Ser Arg Leu Gln20 25 30ttc gac acg cac agg gca tct gcc cga ttt cac aat cat aat agc gga144Phe Asp Thr His Arg Ala Ser Ala Arg Phe His Asn His Asn Ser Gly35 40 45gtt aaa aat atg aca gct aaa gga caa atg ttg caa gat ccc ttc ctg192Val Lys Asn Met Thr Ala Lys Gly Gln Met Leu Gln Asp Pro Phe Leu50 55 60aac gcc ctg cgt aaa gag cat gtt ccg gtt tcg att tac tta gtt aac240Asn Ala Leu Arg Lys Glu His Val Pro Val Ser Ile Tyr Leu Val Asn
65 70 75 80ggt atc aaa ttg caa ggt cag gtt gag tct ttc gat caa tac gtt gtt288Gly Ile Lys Leu Gln Gly Gln Val Glu Ser Phe Asp Gln Tyr Val Val85 90 95ctc ctg aga aac act tcc gtc acc caa atg gtt tac aaa cac gcc att336Leu Leu Arg Asn Thr Ser Val Thr Gln Met Val Tyr Lys His Ala Ile100 105 110tcc acc atc gta ccg gca cgc tcc gtc aac cta caa cat gaa aac aga384Ser Thr Ile Val Pro Ala Arg Ser Val Asn Leu Gln His Glu Asn Arg115 120 125ccc caa gcc gca ccg act tcg acc ctc gtc caa gtg gaa acc gtc cag432Pro Gln Ala Ala Pro Thr Ser Thr Leu Val Gln Val Glu Thr Val Gln130 135 140cag cct gcc gaa444Gln Pro Ala Glu145<210>128<211>148<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>128Val Asp Ala Ala Ala Thr Leu Leu Thr Tyr Lys Cys Pro Ala Glu Asn1 5 10 15Arg Pro Asn Thr Lys Lys Ile Gly Asn Phe Ser Tyr Ser Arg Leu Gln20 25 30Phe Asp Thr His Arg Ala Ser Ala Arg Phe His Asn His Asn Ser Gly35 40 45Val Lys Asn Met Thr Ala Lys Gly Gln Met Leu Gln Asp Pro Phe Leu50 55 60Asn Ala Leu Arg Lys Glu His Val Pro Val Ser Ile Tyr Leu Val Asn65 70 75 80Gly Ile Lys Leu Gln Gly Gln Val Glu Ser Phe Asp Gln Tyr Val Val85 90 95Leu Leu Arg Asn Thr Ser Val Thr Gln Met Val Tyr Lys His Ala Ile
100 105 110Ser Thr Ile Val Pro Ala Arg Ser Val Asn Leu Gln His Glu Asn Arg115 120 125Pro Gln Ala Ala Pro Thr Ser Thr Leu Val Gln Val Glu Thr Val Gln130 135 140Gln Pro Ala Glu145<210>129<211>1308<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1308)<400>129atg tac gct aaa aaa ggc ggt ttg gga ctg gtt aaa agc cgc cgt ttc48Met Tyr Ala Lys Lys Gly Gly Leu Gly Leu Val Lys Ser Arg Arg Phe1 5 10 15gca cct ctt ttc gct acg cag ttt ctc ggc gcg ttc aac gac aat gtg96Ala Pro Leu Phe Ala Thr Gln Phe Leu Gly Ala Phe Asn Asp Asn Val20 25 30ttc aaa acc gcg ctg ttt gtg atg att ggg ttt tac ggt ttg ggg caa144Phe Lys Thr Ala Leu Phe Val Met Ile Gly Phe Tyr Gly Leu Gly Gln35 40 45aac ggc ttc ctg cct gcc gga cag atg ttg aac ttg ggc gcg ttg ctg192Asn Gly Phe Leu Pro Ala Gly Gln Met Leu Asn Leu Gly Ala Leu Leu50 55 60ttt att ttg ccg tat ttc ctg ttt tcc tcg ctg tcg ggg cag ttg ggt240Phe Ile Leu Pro Tyr Phe Leu Phe Ser Ser Leu Ser Gly Gln Leu Gly65 70 75 80aac aaa ttc gac aag gcc gtt ttg gcg cgt tgg gcc aag gtg ctg gaa288Asn Lys Phe Asp Lys Ala Val Leu Ala Arg Trp Ala Lys Val Leu Glu85 90 95atg atc att atg gcg gtg gcg gca tac ggg ttt tat atc cgg tct gcc336
Met Ile Ile Met Ala Val Ala Ala Tyr Gly Phe Tyr Ile Arg Ser Ala100 105 110ccg ctg ctt ttg gcg tgt ctg ttt tgc atg ggc gcg caa tcg acg ctg384Pro Leu Leu Leu Ala Cys Leu Phe Cys Met Gly Ala Gln Ser Thr Leu115 120 125ttc ggg ccg ctg aaa tac gcc atc ctg ccc gat tat ctc gac gac aaa432Phe Gly Pro Leu Lys Tyr Ala Ile Leu Pro Asp Tyr Leu Asp Asp Lys130 135 140gag ttg atg atg ggc aac agc ctg att gaa tcg ggt acg ttt gtc gcc480Glu Leu Met Met Gly Asn Ser Leu Ile Glu Ser Gly Thr Phe Val Ala145 150 155 160atc ctg ttc ggt cag ata ctg ggg act gcg gtg gca ggt gta ccg cct528Ile Leu Phe Gly Gln Ile Leu Gly Thr Ala Val Ala Gly Val Pro Pro165 170 175tat att gtc ggg ata ctg gtt ttg ctg gtc gcc gta gga ggc acg gtc576Tyr Ile Val Gly Ile Leu Val Leu Leu Val Ala Val Gly Gly Thr Val180 185 190ggc agc ctg ttt atg ccg tcc gta ccc gcc aag gct gcc gat aca caa624Gly Ser Leu Phe Met Pro Ser Val Pro Ala Lys Ala Ala Asp Thr Gln195 200 205att gag tgg aat att gtc cgg ggt aca aaa tcc ctg ctg cgt gaa acg672Ile Glu Trp Asn Ile Val Arg Gly Thr Lys Ser Leu Leu Arg Glu Thr210 215 220gtg cgg cac aag ccc gtt ttt acc gcc att atc ggt att tcg tgg ttt720Val Arg His Lys Pro Val Phe Thr Ala Ile Ile Gly Ile Ser Trp Phe225 230 235 240tgg ttt gtc ggc gcg gtt tat acc acg caa ctg ccg acc ttt acc caa768Trp Phe Val Gly Ala Val Tyr Thr Thr Gln Leu Pro Thr Phe Thr Gln245 250 255atc cat cta ggc ggc aac gac aat gtt ttc aac ctg atg ctt gcc ctg816Ile His Leu Gly Gly Asn Asp Asn Val Phe Asn Leu Met Leu Ala Leu260 265 270ttt tcc atc ggt att gcc gcc ggt tcg gta ctg tgt gcc aag ttc agc864Phe Ser Ile Gly Ile Ala Ala Gly Ser Val Leu Cys Ala Lys Phe Ser275 280 285agg gaa cgg ctg agg ttg gct tgg gta acg gtt ggt gcg ttg ggt ttg912
Arg Glu Arg Leu Arg Leu Ala Trp Val Thr Val Gly Ala Leu Gly Leu290 295 300acg gtt tgc ggc ttg gtt ttg gtg tgg ctg acg cac gga cac cgt ttt960Thr Val Cys Gly Leu Val Leu Val Trp Leu Thr His Gly His Arg Phe305 310 315 320gaa ggg ctg aac ggc att ttt tgg ttt tta tcg caa gga tgg gca tat1008Glu Gly Leu Asn Gly Ile Phe Trp Phe Leu Ser Gln Gly Trp Ala Tyr325 330 335ccc gtg atg gcg gtg atg acg ctg atc ggc ttt ttc ggc gga ttt ttc1056Pro Val Met Ala Val Met Thr Leu Ile Gly Phe Phe Gly Gly Phe Phe340 345 350tcc gtt ccg ctc tat acc tgg ctg caa acc gcc agt agc gag act ttc1104Ser Val Pro Leu Tyr Thr Trp Leu Gln Thr Ala Ser Ser Glu Thr Phe355 360 365cgc gcc cgc gcc gtt gcc gcc aac aat atc gtt aac ggt att ttt atg1152Arg Ala Arg Ala Val Ala Ala Asn Asn Ile Val Asn Gly Ile Phe Met370 375 380gtt tcc gct gcc gtt ttg agc gcg gtg ttg ctg ttt ttg ttt gac agc1200Val Ser Ala Ala Val Leu Ser Ala Val Leu Leu Phe Leu Phe Asp Ser385 390 395 400att tcc ttg ttg tat ctg att gtc gct ttg ggc aat att ccg ttg tcg1248Ile Ser Leu Leu Tyr Leu Ile Val Ala Leu Gly Asn Ile Pro Leu Ser405 410 415gta ttt ttg att aag cgc gaa agg cgg ttt tta ggc gcg gcg gca atc1296Val Phe Leu Ile Lys Arg Glu Arg Arg Phe Leu Gly Ala Ala Ala Ile420 425 430agg aaa aaa cct1308Arg Lys Lys Pro435<210>130<211>436<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>130Met Tyr Ala Lys Lys Gly Gly Leu Gly Leu Val Lys Ser Arg Arg Phe1 5 10 15
Ala Pro Leu Phe Ala Thr Gln Phe Leu Gly Ala Phe Asn Asp Asn Val20 25 30Phe Lys Thr Ala Leu Phe Val Met Ile Gly Phe Tyr Gly Leu Gly Gln35 40 45Asn Gly Phe Leu Pro Ala Gly Gln Met Leu Asn Leu Gly Ala Leu Leu50 55 60Phe Ile Leu Pro Tyr Phe Leu Phe Ser Ser Leu Ser Gly Gln Leu Gly65 70 75 80Asn Lys Phe Asp Lys Ala Val Leu Ala Arg Trp Ala Lys Val Leu Glu85 90 95Met Ile Ile Met Ala Val Ala Ala Tyr Gly Phe Tyr Ile Arg Ser Ala100 105 110Pro Leu Leu Leu Ala Cys Leu Phe Cys Met Gly Ala Gln Ser Thr Leu115 120 125Phe Gly Pro Leu Lys Tyr Ala Ile Leu Pro Asp Tyr Leu Asp Asp Lys130 135 140Glu Leu Met Met Gly Asn Ser Leu Ile Glu Ser Gly Thr Phe Val Ala145 150 155 160Ile Leu Phe Gly Gln Ile Leu Gly Thr Ala Val Ala Gly Val Pro Pro165 170 175Tyr Ile Val Gly Ile Leu Val Leu Leu Val Ala Val Gly Gly Thr Val180 185 190Gly Ser Leu Phe Met Pro Ser Val Pro Ala Lys Ala Ala Asp Thr Gln195 200 205Ile Glu Trp Asn Ile Val Arg Gly Thr Lys Ser Leu Leu Arg Glu Thr210 215 220Val Arg His Lys Pro Val Phe Thr Ala Ile Ile Gly Ile Ser Trp Phe225 230 235 240Trp Phe Val Gly Ala Val Tyr Thr Thr Gln Leu Pro Thr Phe Thr Gln245 250 255Ile His Leu Gly Gly Asn Asp Asn Val Phe Asn Leu Met Leu Ala Leu260 265 270
Phe Ser Ile Gly Ile Ala Ala Gly Ser Val Leu Cys Ala Lys Phe Ser275 280 285Arg Glu Arg Leu Arg Leu Ala Trp Val Thr Val Gly Ala Leu Gly Leu290 295 300Thr Val Cys Gly Leu Val Leu Val Trp Leu Thr His Gly His Arg Phe305 310 315 320Glu Gly Leu Asn Gly Ile Phe Trp Phe Leu Ser Gln Gly Trp Ala Tyr325 330 335Pro Val Met Ala Val Met Thr Leu Ile Gly Phe Phe Gly Gly Phe Phe340 345 350Ser Val Pro Leu Tyr Thr Trp Leu Gln Thr Ala Ser Ser Glu Thr Phe355 360 365Arg Ala Arg Ala Val Ala Ala Asn Asn Ile Val Asn Gly Ile Phe Met370 375 380Val Ser Ala Ala Val Leu Ser Ala Val Leu Leu Phe Leu Phe Asp Ser385 390 395 400Ile Ser Leu Leu Tyr Leu Ile Val Ala Leu Gly Asn Ile Pro Leu Ser405 410 415Val Phe Leu Ile Lys Arg Glu Arg Arg Phe Leu Gly Ala Ala Ala Ile420 425 430Arg Lys Lys Pro435<210>131<211>876<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(876)<400>131atg aat tac gca aaa gaa atc aat gcg tta aat aac agc ctt tcc gat48Met Asn Tyr Ala Lys Glu Ile Asn Ala Leu Asn Asn Ser Leu Ser Asp
1 5 10 15ttg aaa ggc gac atc aac gtt tcg ttt gaa ttt ttt cca ccg aaa aac96Leu Lys Gly Asp Ile Aan Val Ser Phe Glu Phe Phe Pro Pro Lys Asn20 25 30gag caa atg gaa acg atg ctg tgg gat tcc atc cac cgt ctg caa acc144Glu Gln Met Glu Thr Met Leu Trp Asp Ser Ile His Arg Leu Gln Thr35 40 45ctg cat ccc aag ttc gta tcc gta acc tac ggc gca aac tcc ggc gaa192Leu His Pro Lys Phe Val Ser Val Thr Tyr Gly Ala Asn Ser Gly Glu50 55 60cgc gac cgc acg cac ggc atc gtc aaa cgc atc aaa cag gaa acc ggc240Arg Asp Arg Thr His Gly Ile Val Lys Arg Ile Lys Gln Glu Thr Gly65 70 75 80ttg gaa gca gca ccg cac ctg acc ggc atc gac gca tcc ccc gac gaa288Leu Glu Ala Ala Pro His Leu Thr Gly Ile Asp Ala Ser Pro Asp Glu85 90 95ttg cgc caa atc gcc aaa gac tat tgg gac agc ggc atc cgc cgc att336Leu Arg Gln Ile Ala Lys Asp Tyr Trp Asp Ser Gly Ile Arg Arg Ile100 105 110gtc gcc ctg cgt ggc gac gag ccg ccc ggt tat gag aaa aaa ccg ttt384Val Ala Leu Arg Gly Asp Glu Pro Pro Gly Tyr Glu Lys Lys Pro Phe115 120 125tac gcc gaa gac ttg gtt aag cta tta cgc tcc gtc gcc gac ttc gac432Tyr Ala Glu Asp Leu Val Lys Leu Leu Arg Ser Val Ala Asp Phe Asp130 135 140atc tct gtg gcg gca tat ccc gaa gtg cat ccc gaa gcc aaa tcc gca480Ile Ser Val Ala Ala Tyr Pro Glu Val His Pro Glu Ala Lys Ser Ala145 150 155 160caa gcc gat ctg att aat ctg aag cgc aaa atc gat gcg ggt gca aac528Gln Ala Asp Leu Ile Asn Leu Lys Arg Lys Ile Asp Ala Gly Ala Asn165 170 175cac gtc atc acc caa ttt ttc ttt gac gta gaa cgc tac ctg cgc ttc576His Val Ile Thr Gln Phe Phe Phe Asp Val Glu Arg Tyr Leu Arg Phe180 185 190cgc gac cgc tgc gtg atg ttg ggt atc gat gtg gaa atc gtc cct ggt624Arg Asp Arg Cys Val Met Leu Gly Ile Asp Val Glu Ile Val Pro Gly
195 200 205att ttg cct gtt acc aac ttc aag cag ctc ggc aaa atg gcg caa gta672Ile Leu Pro Val Thr Asn Phe Lys Gln Leu Gly Lys Met Ala Gln Val210 215 220acc aac gtc aaa atc cca agc tgg ctg tcg caa atg tat gaa ggt ttg720Thr Asn Val Lys Ile Pro Ser Trp Leu Ser Gln Met Tyr Glu Gly Leu225 230 235 240gac gac gac caa ggc acg cgc aac ctc gtc gcc gcc agt atc gcc atc768Asp Asp Asp Gln Gly Thr Arg Asn Leu Val Ala Ala Ser Ile Ala Ile245 250 255gat atg gtc aaa gtc ctg tcc cgc gaa ggc gtg aaa gat ttc cac ttc816Asp Met Val Lys Val Leu Ser Arg Glu Gly Val Lys Asp Phe His Phe260 265 270tac acg ctc aac cgc agc gag ctg act tac gcc atc tgc cat att tta864Tyr Thr Leu Asn Arg Ser Glu Leu Thr Tyr Ala Ile Cys His Ile Leu275 280 285ggc gtg cgc cct876Gly Val Arg Pro290<210>132<211>292<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>132Met Asn Tyr Ala Lys Glu Ile Asn Ala Leu Asn Asn Ser Leu Ser Asp1 5 10 15Leu Lys Gly Asp Ile Asn Val Ser Phe Glu Phe Phe Pro Pro Lys Asn20 25 30Glu Gln Met Glu Thr Met Leu Trp Asp Ser Ile His Arg Leu Gln Thr35 40 45Leu His Pro Lys Phe Val Ser Val Thr Tyr Gly Ala Asn Ser Gly Glu50 55 60Arg Asp Arg Thr His Gly Ile Val Lys Arg Ile Lys Gln Glu Thr Gly65 70 75 80
Leu Glu Ala Ala Pro His Leu Thr Gly Ile Asp Ala Ser Pro Asp Glu85 90 95Leu Arg Gln Ile Ala Lys Asp Tyr Trp Asp Ser Gly Ile Arg Arg Ile100 105 110Val Ala Leu Arg Gly Asp Glu Pro Pro Gly Tyr Glu Lys Lys Pro Phe115 120 125Tyr Ala Glu Asp Leu Val Lys Leu Leu Arg Ser Val Ala Asp Phe Asp130 135 140Ile Ser Val Ala Ala Tyr Pro Glu Val His Pro Glu Ala Lys Ser Ala145 150 155 160Gln Ala Asp Leu Ile Asn Leu Lys Arg Lys Ile Asp Ala Gly Ala Asn165 170 175His Val Ile Thr Gln Phe Phe Phe Asp Val Glu Arg Tyr Leu Arg Phe180 185 190Arg Asp Arg Cys Val Met Leu Gly Ile Asp Val Glu Ile Val Pro Gly195 200 205Ile Leu Pro Val Thr Asn Phe Lys Gln Leu Gly Lys Met Ala Gln Val210 215 220Thr Asn Val Lys Ile Pro Ser Trp Leu Ser Gln Met Tyr Glu Gly Leu225 230 235 240Asp Asp Asp Gln Gly Thr Arg Asn Leu Val Ala Ala Ser Ile Ala Ile245 250 255Asp Met Val Lys Val Leu Ser Arg Glu Gly Val Lys Asp Phe His Phe260 265 270Tyr Thr Leu Asn Arg Ser Glu Leu Thr Tyr Ala Ile Cys His Ile Leu275 280 285Gly Val Arg Pro290<210>133<211>1371<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)
<220>
<221>CDS<222>(1)..(1371)<400>133atg agt aat cca ttt tcc tct tta ggt ttg ggt acg gaa ctc gtt tcc48Met Ser Asn Pro Phe Ser Ser Leu Gly Leu Gly Thr Glu Leu Val Ser1 5 10 15gca ctg acc gcg caa ggt tac gaa aac ccg aca ccc atc caa gcc gcc96Ala Leu Thr Ala Gln Gly Tyr Glu Asn Pro Thr Pro Ile Gln Ala Ala20 25 30gcc att ccc aaa gca ctc gcc ggt cat gat ttg cta gcc gcc gcg caa144Ala Ile Pro Lys Ala Leu Ala Gly His Asp Leu Leu Ala Ala Ala Gln35 40 45acc ggc aca ggc aaa acc gcc gcc ttt atg ctg ccc agt ctg gaa cgc192Thr Gly Thr Gly Lys Thr Ala Ala Phe Met Leu Pro Ser Leu Glu Arg50 55 60ctc aaa cgt tac gcc acc gcc agc acc tcg ccc gcg atg cac ccc gtg240Leu Lys Arg Tyr Ala Thr Ala Ser Thr Ser Pro Ala Met His Pro Val65 70 75 80cgt atg ctc gtc ctc acc ccc acg cgc gaa ctt gcc gac caa atc gac288Arg Met Leu Val Leu Thr Pro Thr Arg Glu Leu Ala Asp Gln Ile Asp85 90 95caa aac gtg cag ggc tac atc aaa aac ctg ccg ctg cgc cac acc gtc336Gln Asn Val Gln Gly Tyr Ile Lys Asn Leu Pro Leu Arg His Thr Val100 105 110ttg ttc ggc ggt atg aat atg gac aaa cag acc gcc gac ctg cgt gcc384Leu Phe Gly Gly Met Asn Met Asp Lys Gln Thr Ala Asp Leu Arg Ala115 120 125ggc tgc gaa atc gtc gtc gcc acc gtc gga cgg ctg ctc gac cac gtg432Gly Cys Glu Ile Val Val Ala Thr Val Gly Arg Leu Leu Asp His Val130 135 140aaa cag aaa aac atc cat ttg aac aaa gtc gaa atc gtc gtt ttg gac480Lys Gln Lys Asn Ile His Leu Asn Lys Val Glu Ile Val Val Leu Asp145 150 155 160gaa gcc gac cgt atg ctg gat atg ggt ttt atc gac gac atc cgc aaa528Glu Ala Asp Arg Met Leu Asp Met Gly Phe Ile Asp Asp Ile Arg Lys
165 170 175atc atg cag atg ctg ccc cgc caa cgc caa acc ctg ctc ttt tcc gcc576Ile Met Gln Met Leu Pro Arg Gln Arg Gln Thr Leu Leu Phe Ser Ala180 185 190acc ttc tcc gcc ccg ata cgc aaa ctg gcg caa gac ttc atg aac gcg624Thr Phe Ser Ala Pro Ile Arg Lys Leu Ala Gln Asp Phe Met Asn Ala195 200 205ccc gaa acc gtc gaa gtc gcc gcg caa gac acc acc aac gcc aac gtc672Pro Glu Thr Val Glu Val Ala Ala Gln Asp Thr Thr Asn Ala Asn Val210 215 220gag cag cac atc atc gcc gtc gat acc att cag aag cgc aac ctg ctc720Glu Gln His Ile Ile Ala Val Asp Thr Ile Gln Lys Arg Asn Leu Leu225 230 235 240gaa cgg ctg att gtc gat ttg cat atg aac cag gtc atc gtg ttc tgc768Glu Arg Leu Ile Val Asp Leu His Met Asn Gln Val Ile Val Phe Cys245 250 255aaa acc aaa caa agc gtc gac cgc gta acg cgc gaa ctg gtg cgc cgc816Lys Thr Lys Gln Ser Val Asp Arg Val Thr Arg Glu Leu Val Arg Arg260 265 270aac ctg tcc gca cag gcg ata cac ggc gac cgt tcc caa caa agc cgg864Asn Leu Ser Ala Gln Ala Ile His Gly Asp Arg Ser Gln Gln Ser Arg275 280 285ctc gaa aca ctc aac gcc ttc aaa gac ggc aac ctg cgc gtc ctc gtc912Leu Glu Thr Leu Asn Ala Phe Lys Asp Gly Asn Leu Arg Val Leu Val290 295 300gcc acc gat atc gcc gcg cgg ggg ctg gat att gcc gaa ctg ccc ttc960Ala Thr Asp Ile Ala Ala Arg Gly Leu Asp Ile Ala Glu Leu Pro Phe305 310 315 320gtc atc aat tac gaa atg ccc gcc cag ccc gaa gac tac gtc cac cgc1008Val Ile Asn Tyr Glu Met Pro Ala Gln Pro Glu Asp Tyr Val His Arg325 330 335atc ggg cgc acg ggg cgc gcg ggc gcg gac ggc gtg gcg att tcc ctg1056Ile Gly Arg Thr Gly Arg Ala Gly Ala Asp Gly Val Ala Ile Ser Leu340 345 350atg gac gaa tcc gaa cag aaa atg ttt gaa tcc att aaa gag ctg acc1104Met Asp Glu Ser Glu Gln Lys Met Phe Glu Ser Ile Lys Glu Leu Thr
355 360 365ggc aac aag ctg ctc atc gag cgc atc gag ggc ttc gag ccg caa tgg1152Gly Asn Lys Leu Leu Ile Glu Arg Ile Glu Gly Phe Glu Pro Gln Trp370 375 380tgg gaa cag ggc ggc gca aaa ccg gaa aaa ccc gaa atg cgc gaa cca1200Trp Glu Gln Gly Gly Ala Lys Pro Glu Lys Pro Glu Met Arg Glu Pro385 390 395 400aga caa cgc aac cgc tac gaa tcc gcc aaa gcg caa cgc gaa aaa aac1248Arg Gln Arg Asn Arg Tyr Glu Ser Ala Lys Ala Gln Arg Glu Lys Asn405 410 415acc cgg ccg gaa aat gcg gca aac gat gcg ggc gcg gct tgc gga aaa1296Thr Arg Pro Glu Asn Ala Ala Asn Asp Ala Gly Ala Ala Cys Gly Lys420 425 430att gcc gga cgc agc cgc cga agc cgc cgg gaa cac cgg acg tgc gcc1344Ile Ala Gly Arg Ser Arg Arg Ser Arg Arg Glu His Arg Thr Cys Ala435 440 445ctg ctc caa ccg cgt tac ggc gta aaa1371Leu Leu Gln Pro Arg Tyr Gly Val Lys450 455<210>134<211>457<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>134Met Ser Asn Pro Phe Ser Ser Leu Gly Leu Gly Thr Glu Leu Val Ser1 5 10 15Ala Leu Thr Ala Gln Gly Tyr Glu Asn Pro Thr Pro Ile Gln Ala Ala20 25 30Ala Ile Pro Lys Ala Leu Ala Gly His Asp Leu Leu Ala Ala Ala Gln35 40 45Thr Gly Thr Gly Lys Thr Ala Ala Phe Met Leu Pro Ser Leu Glu Arg50 55 60Leu Lys Arg Tyr Ala Thr Ala ger Thr Ser Pro Ala Met His Pro Val65 70 75 80
Arg Met Leu Val Leu Thr Pro Thr Arg Glu Leu Ala Asp Gln Ile Asp85 90 95Gln Asn Val Gln Gly Tyr Ile Lys Asn Leu Pro Leu Arg His Thr Val100 105 110Leu Phe Gly Gly Met Asn Met Asp Lys Gln Thr Ala Asp Leu Arg Ala115 120 125Gly Cys Glu Ile Val Val Ala Thr Val Gly Arg Leu Leu Asp His Val130 135 140Lys Gln Lys Asn Ile His Leu Asn Lys Val Glu Ile Val Val Leu Asp145 150 155 160Glu Ala Asp Arg Met Leu Asp Met Gly Phe Ile Asp Asp Ile Arg Lys165 170 175Ile Met Gln Met Leu Pro Arg Gln Arg Gln Thr Leu Leu Phe Ser Ala180 185 190Thr Phe Ser Ala Pro Ile Arg Lys Leu Ala Gln Asp Phe Met Asn Ala195 200 205Pro Glu Thr Val Glu Val Ala Ala Gln Asp Thr Thr Asn Ala Asn Val210 215 220Glu Gln His Ile Ile Ala Val Asp Thr Ile Gln Lys Arg Asn Leu Leu225 230 235 240Glu Arg Leu Ile Val Asp Leu His Met Asn Gln Val Ile Val Phe Cys245 250 255Lys Thr Lys Gln Ser Val Asp Arg Val Thr Arg Glu Leu Val Arg Arg260 265 270Asn Leu Ser Ala Gln Ala Ile His Gly Asp Arg Ser Gln Gln Ser Arg275 280 285Leu Glu Thr Leu Asn Ala Phe Lys Asp Gly Asn Leu Arg Val Leu Val290 295 300Ala Thr Asp Ile Ala Ala Arg Gly Leu Asp Ile Ala Glu Leu Pro Phe305 310 315 320Val Ile Asn Tyr Glu Met Pro Ala Gln Pro Glu Asp Tyr Val His Arg325 330 335
Ile Gly Arg Thr Gly Arg Ala Gly Ala Asp Gly Val Ala Ile Ser Leu340345 350Met Asp Glu Ser Glu Gln Lys Met Phe Glu Ser Ile Lys Glu Leu Thr355 360 365Gly Asn Lys Leu Leu Ile Glu Arg Ile Glu Gly Phe Glu Pro Gln Trp370 375 380Trp Glu Gln Gly Gly Ala Lys Pro Glu Lys Pro Glu Met Arg Glu Pro385 390 395 400Arg Gln Arg Asn Arg Tyr Glu Ser Ala Lys Ala Gln Arg Glu Lys Asn405 410 415Thr Arg Pro Glu Asn Ala Ala Asn Asp Ala Gly Ala Ala Cys Gly Lys420 425 430Ile Ala Gly Arg Ser Arg Arg Ser Arg Arg Glu His Arg Thr Cys Ala435 440 445Leu Leu Gln Pro Arg Tyr Gly Val Lys450 455<210>135<211>1374<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1374)<400>135atg aaa cac atc cac att atc ggt atc ggc ggc acg ttt atg ggt ggg48Met Lys His Ile His Ile Ile Gly Ile Gly Gly Thr Phe Met Gly Gly1 5 10 15att gcc gcc att gcc aaa gaa gca ggg ttt gaa gtc agc ggt tgc gat96Ile Ala Ala Ile Ala Lys Glu Ala Gly Phe Glu Val Ser Gly Cys Asp20 25 30gcg aag atg tat ccg ccg atg agc acc cag ctc gaa gcc ttg ggc ata144Ala Lys Met Tyr Pro Pro Met Ser Thr Gln Leu Glu Ala Leu Gly Ile35 40 45
ggc gtg tat gaa ggc ttc gac acc gcg cag ttg gac gaa ttt aaa gcc192Gly Val Tyr Glu Gly Phe Asp Thr Ala Gln Leu Asp Glu Phe Lys Ala50 55 60gac gtt tac gtt atc ggc aat gtc gcc aag cgc ggg atg gat gtg gtt240Asp Val Tyr Val Ile Gly Asn Val Ala Lys Arg Gly Met Asp Val Val65 70 75 80gaa gcg att ttg aac cgt ggg ctg cct tat att tcc ggc ccg caa tgg288Glu Ala Ile Leu Asn Arg Gly Leu Pro Tyr Ile Ser Gly Pro Gln Trp85 90 95ctg gct gaa aac gtg ctg cac cat cat tgg gta ctc ggc gtg gcg ggg336Leu Ala Glu Asn Val Leu His His His Trp Val Leu Gly Val Ala Gly100 105 110acg cac ggc aaa acg acc acc gcg tct atg ctc gcg tgg gtt ttg gaa384Thr His Gly Lys Thr Thr Thr Ala Ser Met Leu Ala Trp Val Leu Glu115 120 125tat gcc gga ctc gca ccg ggc ttc ctt atc ggc ggc gta ccg gaa aac432Tyr Ala Gly Leu Ala Pro Gly Phe Leu Ile Gly Gly Val Pro Glu Asn130 135 140ttc agc gtt tcc gcc cgc ctg ccg caa acg ccg cgc caa gac ccg aac480Phe Ser Val Ser Ala Arg Leu Pro Gln Thr Pro Arg Gln Asp Pro Asn145 150 155 160agc caa tcg ccg ttt ttc gtc att gaa gcc gac gaa tac gac acc gcg528Ser Gln Ser Pro Phe Phe Val Ile Glu Ala Asp Glu Tyr Asp Thr Ala165 170 175ttt ttc gac aaa cgc tcc aaa ttc gtg cat tac cgt ccg cgt acc gcc576Phe Phe Asp Lys Arg Ser Lys Phe Val His Tyr Arg Pro Arg Thr Ala180 185 190gtg ttg aac aat ctg gaa ttc gac cac gcc gac atc ttc gcc gat ttg624Val Leu Asn Asn Leu Glu Phe Asp His Ala Asp Ile Phe Ala Asp Leu195 200 205ggc gcg ata cag acc cag ttc cac cac ctc gtg cgt acc gtg ccg tct672Gly Ala Ile Gln Thr Gln Phe His His Leu Val Arg Thr Val Pro Ser210 215 220gaa ggc ctc atc gtc tgc aac gga cgg cag caa agc ctg caa gac act720Glu Gly Leu Ile Val Cys Asn Gly Arg Gln Gln Ser Leu Gln Asp Thr225 230 235 240
ttg gac aaa ggc tgc tgg acg ccg gtg gaa aaa ttc ggc acg gaa cac768Leu Asp Lys Gly Cys Trp Thr Pro Val Glu Lys Phe Gly Thr Glu His245 250 255ggc tgg cag gcc ggc gaa gcc aat gcc gat ggc tcg ttc gac gtg ttg816Gly Trp Gln Ala Gly Glu Ala Asn Ala Asp Gly Ser Phe Asp Val Leu260 265 270ctt gac ggc aaa aaa gcc gga cac gtc gct tgg agt ttg atg ggc gga864Leu Asp Gly Lys Lys Ala Gly His Val Ala Trp Ser Leu Met Gly Gly275 280 285cac aac cgc atg aac gcg ctc gcc gtc atc gcc gcc gcg cgt cat gcc912His Asn Arg Met Asn Ala Leu Ala Val Ile Ala Ala Ala Arg His Ala290 295 300gga gtc gac att cag acg gcc tgc gaa gcc ttg agc acg ttt aaa aac960Gly Val Asp Ile Gln Thr Ala Cys Glu Ala Leu Ser Thr Phe Lys Asn305 310 315 320gtc aaa cgc cgc atg gaa atc aaa ggc acg gca aac ggt atc acc gtt1008Val Lys Arg Arg Met Glu Ile Lys Gly Thr Ala Asn Gly Ile Thr Val325 330 335tac gac gac ttc gcc cac cat ccg acc gct atc gaa acc acg att caa1056Tyr Asp Asp Phe Ala His His Pro Thr Ala Ile Glu Thr Thr Ile Gln340 345 350ggt ttg cgc cag cgc gtc ggc ggc gcg cgc atc ctc gcc gtc ctc gaa1104Gly Leu Arg Gln Arg Val Gly Gly Ala Arg Ile Leu Ala Val Leu Glu355 360 365ccg cgt tcc aat acg atg aag ctg ggt acg atg aaa gcc gcc ctg ccc1152Pro Arg Ser Asn Thr Met Lys Leu Gly Thr Met Lys Ala Ala Leu Pro370 375 380gca agc ctc aaa gaa gcc gac caa gtg ttc tgc tac gcc ggc ggc gcg1200Ala Ser Leu Lys Glu Ala Asp Gln Val Phe Cys Tyr Ala Gly Gly Ala385 390 395 400gac tgg gac gtt gcc gaa gcc ctc gcg cct ttg ggc ggc agg ctg cac1248Asp Trp Asp Val Ala Glu Ala Leu Ala Pro Leu Gly Gly Arg Leu His405 410 415gtc ggc aaa gsc ttc gat gcc ttc gtt gcc gaa atc gtg aaa aac gcc1296Val Gly Lys Asp Phe Asp Ala Phe Val Ala Glu Ile Val Lys Asn Ala420 425 430
gaa gca ggc gac cat att ttg gtg atg agc aac ggc ggt ttc ggc gga1344Glu Ala Gly Asp His Ile Leu Val Met Ser Asn Gly Gly Phe Gly Gly435 440 445ata cac acc aaa ctg ctg gac gct ttg aga1374Ile His Thr Lys Leu Leu Asp Ala Leu Arg450 455<210>136<211>458<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>136Met Lys His Ile His Ile Ile Gly Ile Gly Gly Thr Phe Met Gly Gly1 5 10 15Ile Ala Ala Ile Ala Lys Glu Ala Gly Phe Glu Val Ser Gly Cys Asp20 25 30Ala Lys Met Tyr Pro Pro Met Ser Thr Gln Leu Glu Ala Leu Gly Ile35 40 45Gly Val Tyr Glu Gly Phe Asp Thr Ala Gln Leu Asp Glu Phe Lys Ala50 55 60Asp Val Tyr Val Ile Gly Asn Val Ala Lys Arg Gly Met Asp Val Val65 70 75 80Glu Ala Ile Leu Asn Arg Gly Leu Pro Tyr Ile Ser Gly Pro Gln Trp85 90 95Leu Ala Glu Asn Val Leu His His His Trp Val Leu Gly Val Ala Gly100 105 110Thr His Gly Lys Thr Thr Thr Ala Ser Met Leu Ala Trp Val Leu Glu115 120 125Tyr Ala Gly Leu Ala Pro Gly Phe Leu Ile Gly Gly Val Pro Glu Asn130 135 140Phe Ser Val Ser Ala Arg Leu Pro Gln Thr Pro Arg Gln Asp Pro Asn145 150 155 160Ser Gln Ser Pro Phe Phe Val Ile Glu Ala Asp Glu Tyr Asp Thr Ala165 170 175
Phe Phe Asp Lys Arg Ser Lys Phe Val His Tyr Arg Pro Arg Thr Ala180 185 190Val Leu Asn Asn Leu Glu Phe Asp His Ala Asp Ile Phe Ala Asp Leu195 200 205Gly Ala Ile Gln Thr Gln Phe His His Leu Val Arg Thr Val Pro Ser210 215 220Glu Gly Leu Ile Val Cys Asn Gly Arg Gln Gln Ser Leu Gln Asp Thr225 230 235 240Leu Asp Lys Gly Cys Trp Thr Pro Val Glu Lys Phe Gly Thr Glu His245 250 255Gly Trp Gln Ala Gly Glu Ala Asn Ala Asp Gly Ser Phe Asp Val Leu260 265 270Leu Asp Gly Lys Lys Ala Gly His Val Ala Trp Ser Leu Met Gly Gly275 280 285His Asn Arg Met Asn Ala Leu Ala Val Ile Ala Ala Ala Arg His Ala290 295 300Gly Val Asp Ile Gln Thr Ala Cys Glu Ala Leu Ser Thr Phe Lys Asn305 310 315 320Val Lys Arg Arg Met Glu Ile Lys Gly Thr Ala Asn Gly Ile Thr Val325 330 335Tyr Asp Asp Phe Ala His His Pro Thr Ala Ile Glu Thr Thr Ile Gln340 345 350Gly Leu Arg Gln Arg Val Gly Gly Ala Arg Ile Leu Ala Val Leu Glu355 360 365Pro Arg Ser Asn Thr Met Lys Leu Gly Thr Met Lys Ala Ala Leu Pro370 375 380Ala Ser Leu Lys Glu Ala Asp Gln Val Phe Cys Tyr Ala Gly Gly Ala385 390 395 400Asp Trp Asp Val Ala Glu Ala Leu Ala Pro Leu Gly Gly Arg Leu His405 410 415Val Gly Lys Asp Phe Asp Ala Phe Val Ala Glu Ile Val Lys Asn Ala420 425 430
Glu Ala Gly Asp His Ile Leu Val Met Ser Asn Gly Gly Phe Gly Gly435 440 445Ile His Thr Lys Leu Leu Asp Ala Leu Arg450 455<210>137<211>876<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(876)<400>137ttg acc gtc cga acg aaa aag acg gcg cat tat acc cta ttc cat tcc48Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser1 5 10 15gac cga aaa ccg aac atg act act ctc aaa ccc gcc ctg ccc gct tat96Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr20 25 30ctg gac aac atc cgc atc atc ctc acg cgc acc agc cat ccc gcc aac144Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn35 40 45atc ggc tct gcc gcg cgc gcg atg aaa aca atg ggt ctg cac aaa ctg192Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu50 55 60acc atc gtc gcc cca aat ctg atg gca acg ccg atg acg gaa aac ccg240Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro65 70 75 80ccc gtg ttt gac ccg gag cat cct caa tcg ttt aaa tta ccg gaa gaa288Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu85 90 95agc ttc atc ctc gct tcc ggc gcg gca gac gtt ttg gaa aat gcc acc336Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr100 105 110att gcc gct tct ttg gac gaa gcc ctt gcc gac acc acc atc gcc tgc384Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys
115 120 125gcc ctg acc agc cgc cgc cgc gaa att act gcg ccg ctg caa acc ccg432Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro130 135 140cgc gat ttg gta tcc gaa tta ctg cag acc gca aac cga ggc gag aaa480Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys145 150 155 160gtg gca ctg gtt ttc ggc aac gag act ttc ggc ttg agc atc gaa gaa528Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu165 170 175gtc caa gcc tgc aac cga ctg atg acc atc aac ggc aat ccc gac tat576Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr180 185 190ttc tcg ctc aac ctc gcc caa gcc gtg cag gtc gtg tgc tac gaa atc624Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile195 200 205ttc agc caa acc ggt tcg ccc atg acc cat ctt caa caa gaa gac cac672Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His210 215 220gct gcg acc cac gag caa atc aaa ggc atg gtc gcc cac atg gaa agc720Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser225 230 235 240gtg atg aac gac atc ggc ttt ttc aac cgc cgc aac ggc gag cgt ctg768Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu245 250 255atg cgc cgt atg cag agc ctg ttc gga cgc gcc aac acg caa acc gaa816Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu260 265 270gac atc gat atc ctg cgc ggt ttt ttc aat acc gtc agc cat cgt atc864Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile275 280 285cat aaa aaa gac876His Lys Lys Asp290<210>138
<211>292<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>138Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser1 5 10 15Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr20 25 30Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn35 40 45Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu50 55 60Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro65 70 75 80Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu85 90 95Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr100 105 110Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys115 120 125Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro130 135 140Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys145 150 155 160Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu165 170 175Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr180 185 190Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile195 200 205Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His210 215 220Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser
225 230 235 240Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu245 250 255Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu260 265 270Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile275 280 285His Lys Lys Asp290<210>139<211>708<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(708)<400>139ttg cgg cag ctt gga tgt ttg att ggt ttt ttc agt gtt gga atc att48Leu Arg Gln Leu Gly Cys Leu Ile Gly Phe Phe Ser Val Gly Ile Ile1 5 10 15atg aat ttg aaa tta gtg ttt gaa tcg ggc gat ccc gtc ctg atc ggt96Met Asn Leu Lys Leu Val Phe Glu Ser Gly Asp Pro Val Leu Ile Gly20 25 30gtg ttt gtg ttg atg ctg ttg atg agt atc gta acg tgg tgt ttg gtt144Val Phe Val Leu Met Leu Leu Met Ser Ile Val Thr Trp Cys Leu Val35 40 45gtc ttg cgc tgc atc aag ctg tat cgg gcg cgc aaa ggg aat gcc gcc192Val Leu Arg Cys Ile Lys Leu Tyr Arg Ala Arg Lys Gly Asn Ala Ala50 55 60gtc aaa cgg cat atg cgc gat act ttg tcg ctg aac gac gcg gtc gaa240Val Lys Arg His Met Arg Asp Thr Leu Ser Leu Asn Asp Ala Val Glu65 70 75 80aaa gtg cgc gcc gtc gat gcg cct ttg tcc aaa ctg gcg caa gag gca288Lys Val Arg Ala Val Asp Ala Pro Leu Ser Lys Leu Ala Gln Glu Ala
85 90 95ttg cag tct tac cgc aac tac cgc cga aac gaa gcg tcc gaa ctg gcg336Leu Gln Ser Tyr Arg Asn Tyr Arg Arg Asn Glu Ala Ser Glu Leu Ala100 105 110cag gct ttg ccg ttg aac gag tat ttg gtc att caa atc cgc aac agt384Gln Ala Leu Pro Leu Asn Glu Tyr Leu Val Ile Gln Ile Arg Asn Ser115 120 125atg gcg cag att atg cgc cgg ttt gat tac ggg atg acc gcg ctt gcc432Met Ala Gln Ile Met Arg Arg Phe Asp Tyr Gly Met Thr Ala Leu Ala130 135 140tcc atc ggc gcg acc gcg ccg ttt atc ggg ttg ttc ggc acg gtt tgg480Ser Ile Gly Ala Thr Ala Pro Phe Ile Gly Leu Phe Gly Thr Val Trp145 150 155 160ggg att tac cac gcc ctg atc aat atc ggg caa agc ggg cag atg agt528Gly Ile Tyr His Ala Leu Ile Asn Ile Gly Gln Ser Gly Gln Met Ser165 170 175att gcg gcg gtt gcc ggc ccg att ggc gag gca ctg gtg gcg acg gcg576Ile Ala Ala Val Ala Gly Pro Ile Gly Glu Ala Leu Val Ala Thr Ala180 185 190gcg ggt ttg ttc gtg gcg att ccg gcg gtg ttg gca tac aac ttc ctc624Ala Gly Leu Phe Val Ala Ile Pro Ala Val Leu Ala Tyr Asn Phe Leu195 200 205aat cgc ggc aca aaa ata ctg acc cag gat ttg gat gcg atg gcg cac672Asn Arg Gly Thr Lys Ile Leu Thr Gln Asp Leu Asp Ala Met Ala His210 215 220gat ttg cac gtc cgc ctg ctt aat caa aag gat agc708Asp Leu His Val Arg Leu Leu Asn Gln Lys Asp Ser225 230 235<210>140<211>236<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>140Leu Arg Gln Leu Gly Cys Leu Ile Gly Phe Phe Ser Val Gly Ile Ile1 5 10 15
Met Asn Leu Lys Leu Val Phe Glu Ser Gly Asp Pro Val Leu Ile Gly20 25 30Val Phe Val Leu Met Leu Leu Met Ser Ile Val Thr Trp Cys Leu Val35 40 45Val Leu Arg Cys Ile Lys Leu Tyr Arg Ala Arg Lys Gly Asn Ala Ala50 55 60Val Lys Arg His Met Arg Asp Thr Leu Ser Leu Asn Asp Ala Val Glu65 70 75 80Lys Val Arg Ala Val Asp Ala Pro Leu Ser Lys Leu Ala Gln Glu Ala85 90 95Leu Gln Ser Tyr Arg Asn Tyr Arg Arg Asn Glu Ala Ser Glu Leu Ala100 105 110Gln Ala Leu Pro Leu Asn Glu Tyr Leu Val Ile Gln Ile Arg Asn Ser115 120 125Met Ala Gln Ile Met Arg Arg Phe Asp Tyr Gly Met Thr Ala Leu Ala130 135 140Ser Ile Gly Ala Thr Ala Pro Phe Ile Gly Leu Phe Gly Thr Val Trp145 150 155 160Gly Ile Tyr His Ala Leu Ile Asn Ile Gly Gln Ser Gly Gln Met Ser165 170 175Ile Ala Ala Val Ala Gly Pro Ile Gly Glu Ala Leu Val Ala Thr Ala180 185 190Ala Gly Leu Phe Val Ala Ile Pro Ala Val Leu Ala Tyr Asn Phe Leu195 200 205Asn Arg Gly Thr Lys Ile Leu Thr Gln Asp Leu Asp Ala Met Ala His210 215 220Asp Leu His Val Arg Leu Leu Asn Gln Lys Asp Ser225 230 235<210>141<211>812<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)
<220>
<221>CDS<222>(1)..(810)<400>141atg act atg cac gcc ctc ccc cgc tac gcc gtt ttt ggc aac ccc gtc48Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val1 5 10 15gcc cac agc aaa tcg ccg caa att cat caa caa ttt gcc ctt cag gaa96Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu20 25 30ggc gtt gac att gaa tac gaa cgc att tgc gcc gac atc ggc ggt ttc144Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe35 40 45gcg cag gcg gtt tcg aca ttt ttt gaa aca ggc ggt tgc ggg gca aac192Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn50 55 60gtt acc gta ccg ttc aag cag gaa gcg ttt cat ctg gcg gac gag cat240Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His65 70 75 80tct gaa cgc gca ttg gct gcc ggc gcg gtc aac acg ctg att ttt ctg288Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu85 90 95aaa aac gga aaa ctg cgc ggc gac aat acc gac ggt atc ggt ttg gcc336Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala100 105 110aac gac atc acg cag gtc aaa aac att gcc atc gaa ggc aaa acc atc384Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile115 120 125ttg ctt ttg ggc gcg ggc ggc gcg gtg cgc ggc gtg att cct gtt ttg432Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu130 135 140aaa gaa cac cgt cct gcc cgt atc gtc att gcc aac cgt acc cgc gcc480Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala145 150 155 160aaa gcc gag gaa ttg gcg cag ctt ttc ggc att gaa gcc gtc ccg atg528Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met
165 170 175gcg gat gtg aac ggc ggt ttt gat atc atc atc aac ggc acg tcg ggc576Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly180 185 190ggt cta aac ggt cag att ccc gat att ccg ccc gat att ttt caa aac624Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn195 200 205tgc gcg ctt gcc tac gat atg gtg tac ggc tgc gcg gca aaa ccg ttt672Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe210 215 220tta gat ttt gca cga caa tcg ggt gcg aaa aaa act gcc gac gga ctg720Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu225 230 235 240ggt atg cta gtc ggt caa gcg gcg gct tcc tac gcc ctc tgg cgc gga768Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly245 250 255ttt acg ccc gat atc cgc ccc gtt atc gaa tac atg aaa gcc ct 812Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala260 265 270<210>142<211>270<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>142Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val1 5 10 15Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu20 25 30Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe35 40 45Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn50 55 60Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His65 70 75 80
Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu85 90 95Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala100 105 110Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile115 120 125Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu130 135 140Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala145 150 155 160Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met165 170 175Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly180 185 190Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn195 200 205Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe210 215 220Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu225 230 235 240Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly245 250 255Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala260 265 270<210>143<211>1515<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1515)<400>143
atg ttg tat ttc aga tac ggt ttt ttg gtt gtt tgg tgt gcg gca ggt48Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly1 5 10 15gtt tct gcc gcc tat ggg gcg gat gcg ccc gcg att ttg gat gac aag96Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys20 25 30gca ttg ttg cag gtg cag cgg tcg gtg tcg gat aag tgg gcg gaa tcg144Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser35 40 45gat tgg aaa gtt gac aat gat gcc ccg cgc gtg gtt gac ggg gat ttt192Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe50 55 60ttg ttg gcg cat ccg aaa atg ttg gaa cat agt ttg cgc gac gtg ctc240Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu65 70 75 80aac ggc aat cag gcg gat ttg atc gct tcg ttg gcg gat ttg tat gcc288Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala85 90 95aag ctg ccg gat tat gac gcg gtt ttg tac ggc agg gcg cgg gct ttg336Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu100 105 110ctg gcg aaa ttg gcg gga agg ccg gcg gag gcg gtg gcg cgg tat cgg384Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg115 120 125gaa ctg cac ggg gaa aat gcg gca gac gag cgg att ttg ctg gat ttg432Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu130 135 140gcg gcg gcg gag ttt gac gat ttc cgg ctg aag tcg gca gaa agg cat480Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His145 150 155 160ttt gcc gag gcg gaa aaa ttg gat ttg ccg gcg ccg gtt ttg gaa aat528Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn165 170 175gtg ggg cgt ttt cgg aaa aaa gcg gag ggg ctg acg ggc tgg cgt ttt576Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe180 185 190
tcg ggc ggc atc agt ccg gcg gtc aat aga aat gcc aat aat gcc gcg624Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala195 200 205ccg cag tat tgc cgg caa aac gga ggc cgg cag ata tgc agt gtc agc672Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser210 215 220cgg gcg gag cgg gcg gca ggc ttg aat tat gaa atc gag gcg gaa aaa720Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys225 230 235 240ctg acg gcg ttg gca gat aat cat tat ttg ttg ttc cgt tcc aat atc768Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile245 250 255ggc ggc acg agc tat tat ttc agt aaa aaa tca gct tat gac gac ggg816Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly260 265 270ttc ggc aga gcg tat ttg ggt tgg cag tat aaa aat gca cgg cag acg864Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr275 280 285gcg ggg att ttg ccg ttt tat cag gtg cag ttg tcg ggc agc gac ggc912Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly290 295 300ttt gat gcg aaa aca aaa cgg gta aac aac cgc cgc ctg ccg ccg tat960Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr305 310 315 320atg ctg gcg cac gga gtc ggc gtg cag ttg tcc cat act tac cgc cca1008Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro325 330 335aac ccg gga tgg caa ttt tcg gtc gcg ctg gaa cat tac cgc caa cgc1056Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg340 345 350tac cgc gaa cag gat agg gcg gaa tac aat aac ggt cgg cag gac ggg1104Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly355 360 365ttt tat gtt tcg tcg gca aaa cgt ttg ggc gaa tcg gca act gtg ttc1152Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe370 375 380
ggc ggc tgg cag ttt gtg cgg ttt gtg ccg aaa cgc gaa acg gtg ggc 1200Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly385 390 395 400ggc gcg gtc aat aat gcc gcc tac cgg cgc aac ggt gtt tat gcc ggc 1248Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly405 410 415tgg gcg cag gag tgg cgg cag ttg ggc ggt ttg aac agt cgg gtt tcc 1296Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser420 425 430gcg tct tat gcc cgc cgc aac tat aag ggc gtt gcg gct ttc tcg aca 1344Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr435 440 445gag gcg caa cgc aac cgc gaa tgg aat gtc tcg ctg gct ttg agc cac 1392Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His450 455 460gac aag ttg tcg tac aaa ggt atc gtg ccc gcg ttg aat tat cgt ttc 1440Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe465 470 475 480ggc agg acg gaa agt aat gtg ccg tat gcg aaa cgc cgc aac agc gag 1488Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu485 490 495gtg ttt gtg tcg gcg gat tgg cgg ttt 1515Val Phe Val Ser Ala Asp Trp Arg Phe500 505<210>144<211>505<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>144Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly1 5 10 15Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys20 25 30Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser35 40 45
Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe50 55 60Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu65 70 75 80Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala85 90 95Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu100 105 110Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg115 120 125Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu130 135 140Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His145 150 155 160Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn165 170 175Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe180 185 190Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala195 200 205Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser210 215 220Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys225 230 235 240Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile245 250 255Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly260 265 270Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr275 280 285Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly290 295 300
Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr305 310 315 320Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro325 330 335Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg340 345 350Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly355 360 365Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe370 375 380Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly385 390 395 400Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly405 410 415Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser420 425 430Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr435 440 445Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His450 455 460Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe465 470 475 480Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu485 490 495Val Phe Val Ser Ala Asp Trp Arg Phe500 505<210>145<211>840<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS
<222>(1)..(840)<400>145atg gat aaa gaa cga att tta acc ccc gca gtc gtg ttt tcc gtc gca48Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala1 5 10 15ctg ctg cat ttg gca atg gtg gca ttg ctc tgg cag gcg cac aag ctg96Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu20 25 30ccc gtg ata gag tca ggc aat gtt att gaa ttt gtc gat ttg ggc gat144Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp35 40 45ttt ggc gga ggg gac ggc gca ccc gaa ggt gca ggc gcg cct gcc gcg192Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala50 55 60ccc gaa ccg caa ccc gtg ccc gag ccg ccc aaa cct gtc gag ccg ccc240Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro65 70 75 80aag ccg gtt ttg aag ccg gtg gtt acg aaa aag gcg gat gcg gat att288Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile85 90 95cag cag cct aag gaa gag ccg aaa cct gaa gaa aag ccg aaa ccc gaa336Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu100 105 110gaa aaa ccg aaa cca gag cct aag ccg gaa gcg aag cct gtc ccg aaa384Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys115 120 125ccg gcg gaa aaa ccg gtc gag aag ccg tct gaa aaa cct gcc gaa cat432Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His130 135 140ccc ggc aat gct tct gcc aaa gca gac agc gag cag ggc aat ggg gaa480Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu145 150 155 160gat aag gga acc ggt atc aaa gga gac gga acg ggg cgc gga gaa ggc528Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly165 170 175agc ggt aaa ggt agc ggc ggt gtc aaa ggc gaa cac ggg gaa gga gcc576
Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala180 185 190ggc agc agc aaa ggc aat cct tta cgc gcc aac ggc agc att ccg cgc624Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg195 200 205ccg gct tat ccc acg ctt tct atg gag aat gat gag cag ggt acg gtt672Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val210 215 220gtt ttg agc gtt ttg gtt tct ccg ggc ggt cat gtt gag tcc gtt aaa720Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys225 230 235 240atc gtg aaa agc agt ggt ttt tcc cgg ttg gac aat gcg gca cgc aag768Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys245 250 255gcg gcg caa aac ggg cat ttt caa gcc aat gcc tgg acg gag ttt aaa816Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys260 265 270gtc ccc gtc aag ttt gaa ttg aat840Val Pro Val Lys Phe Glu Leu Asn275 280<210>146<211>280<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>146Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala1 5 10 15Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu20 25 30Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp35 40 45Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala50 55 60Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro65 70 75 80
Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile85 90 95Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu100 105 110Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys115 120 125Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His130 135 140Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu145 150 155 160Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly165 170 175Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala180 185 190Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg195 200 205Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val210 215 220Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys225 230 235 240Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys245 250 255Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys260 265 270Val Pro Val Lys Phe Glu Leu Asn275 280<210>147<211>1572<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1572)<400>147atg ttc aga cgg tat ctt ccg aac aga cag atg aat atg gtt tcc aaa48Met Phe Arg Arg Tyr Leu Pro Asn Arg Gln Met Asn Met Val Ser Lys1 5 10 15ctg gac aaa tac tgg cag cac ccc gcc ctc tac tgg cct ttg ctc atc96Leu Asp Lys Tyr Trp Gln His Pro Ala Leu Tyr Trp Pro Leu Leu Ile20 25 30ctt ttt gcc gcc gcc acc ccc ttt acc ttc gca ccc tac tac cac ttt144Leu Phe Ala Ala Ala Thr Pro Phe Thr Phe Ala Pro Tyr Tyr His Phe35 40 45tgg ctg atg ccc ttg att ttc ggt gcc ttc gtc cgc ctc atc gaa ctg192Trp Leu Met Pro Leu Ile Phe Gly Ala Phe Val Arg Leu Ile Glu Leu50 55 60cgt ccg cgt ttt gct gtc tct tcc gcc tac ctg ttc ggc ctg acc gca240Arg Pro Arg Phe Ala Val Ser Ser Ala Tyr Leu Phe Gly Leu Thr Ala65 70 75 80tac acg aca cag ttc tac tgg ata cac acc gcc ctg cac gac gtt tcc288Tyr Thr Thr Gln Phe Tyr Trp Ile His Thr Ala Leu His Asp Val Ser85 90 95ggc ctg ccc gac ctc tat gcc gta ccg ctg acc ttc cta ctc ccc gcc336Gly Leu Pro Asp Leu Tyr Ala Val Pro Leu Thr Phe Leu Leu Pro Ala100 105 110tac ctt gcc ctt tat ccg gca ctg tgt ttc tgg ctg tgg aaa aaa ttt384Tyr Leu Ala Leu Tyr Pro Ala Leu Cys Phe Trp Leu Trp Lys Lys Phe115 120 125acc ctg cct cgg ggc ata aaa atc ggt ttg gta ctg ccc atc ctg tgg432Thr Leu Pro Arg Gly Ile Lys Ile Gly Leu Val Leu Pro Ile Leu Trp130 135 140aca ctg acc gag ttt gcc cgc gaa cgt ttc ctg acc gga ttc ggc tgg480Thr Leu Thr Glu Phe Ala Arg Glu Arg Phe Leu Thr Gly Phe Gly Trp145 150 155 160ggc gca atc ggc tac tcc caa atc acc ccg gac agc ccg ctc gcc ggc528Gly Ala Ile Gly Tyr Ser Gln Ile Thr Pro Asp Ser Pro Leu Ala Gly165 170 175
ttt gcc cca ttt ggc ggc atc cac atg gtt aca ctg gca acc gcc ttt576Phe Ala Pro Phe Gly Gly Ile His Met Val Thr Leu Ala Thr Ala Phe180 185 190ctc ggt gtc tgg ctg gtt ttg gcg agt gat aac acc gca cgt tcg ggc624Leu Gly Val Trp Leu Val Leu Ala Ser Asp Asn Thr Ala Arg Ser Gly195 200 205aaa cgc ctg ctt cca att atc ctg att gcc gcc ctg ctt gcc gca ggc672Lys Arg Leu Leu Pro Ile Ile Leu Ile Ala Ala Leu Leu Ala Ala Gly210 215 220tac acc gcc cga caa acc gac ttc acc cgc ccc gac ggc agc cgc agc720Tyr Thr Ala Arg Gln Thr Asp Phe Thr Arg Pro Asp Gly Ser Arg Ser225 230 235 240acc gtc gcc ctg ctt caa ggc aac atc gac caa acc ctc aaa tgg cgt768Thr Val Ala Leu Leu Gln Gly Asn Ile Asp Gln Thr Leu Lys Trp Arg245 250 255gaa gac caa gtc atc ccg acc ata cag aaa tat tac gaa cag gtc ggc816Glu Asp Gln Val Ile Pro Thr Ile Gln Lys Tyr Tyr Glu Gln Val Gly260 265 270aaa acc act gcc gac atc gtc atc ctg ccc gaa acc gcc atc ccc gtc864Lys Thr Thr Ala Asp Ile Val Ile Leu Pro Glu Thr Ala Ile Pro Val275 280 285atg cgc caa aac ctg ccg gaa aac ata ctg gca aaa ttt gcc gaa cag912Met Arg Gln Asn Leu Pro Glu Asn Ile Leu Ala Lys Phe Ala Glu Gln290 295 300gcg caa aac aac ggc agc gcg ctc gcc gtc ggc atc agc caa tac act960Ala Gln Asn Asn Gly Ser Ala Leu Ala Val Gly Ile Ser Gln Tyr Thr305 310 315 320tcg gac ggc aac ggt tac gaa aac gcc gtc atc aac ctg acc ggt tat1008Ser Asp Gly Asn Gly Tyr Glu Asn Ala Val Ile Asn Leu Thr Gly Tyr325 330 335cag gaa aac aat cag gac ggc atc ccc tac tac gcc aaa aac cac ctc1056Gln Glu Asn Asn Gln Asp Gly Ile Pro Tyr Tyr Ala Lys Asn His Leu340 345 350gtc ccc ttc ggc gaa tac aaa ccg ctg ccc ttc ctg acc acg ccg ctt1104Val Pro Phe Gly Glu Tyr Lys Pro Leu Pro Phe Leu Thr Thr Pro Leu355 360 365
tac aaa atg atg aat atg ccc ctt tcc gac ttc cgc aaa ggc ggc ggt1152Tyr Lys Met Met Asn Met Pro Leu Ser Asp Phe Arg Lys Gly Gly Gly370 375 380aag caa tcc gcc ctg ctg atg aaa aac caa aaa atc gcc ttc aac atc1200Lys Gln Ser Ala Leu Leu Met Lys Asn Gln Lys Ile Ala Phe Asn Ile385 390 395 400tgt tac gaa gac gga ttc ggc gac gaa ctg att gcc gcc gcc aaa gat1248Cys Tyr Glu Asp Gly Phe Gly Asp Glu Leu Ile Ala Ala Ala Lys Asp405 410 415gcc aca ctg ctt gcc aat gcc agc aat atg gcg tgg tac gga aaa tcc1296Ala Thr Leu Leu Ala Asn Ala Ser Asn Met Ala Trp Tyr Gly Lys Ser420 425 430aac gcc atg tac cag cac ctc caa caa tcg cag gcg cgg gct atg gaa1344Asn Ala Met Tyr Gln His Leu Gln Gln Ser Gln Ala Arg Ala Met Glu435 440 445ctc gga cgc tat atg gtc cgt gcc acc aac acc ggc gca acc gcc atc1392Leu Gly Arg Tyr Met Val Arg Ala Thr Asn Thr Gly Ala Thr Ala Ile450 455 460atc tcc ccc aaa ggc aac atc atc gcc caa gcc caa ccc gat acg gaa1440Ile Ser Pro Lys Gly Asn Ile Ile Ala Gln Ala Gln Pro Asp Thr Glu465 470 475 480acc gta ttg gaa gga cac atc aaa ggc tat gtc ggc gaa acg ccc tat1488Thr Val Leu Glu Gly His Ile Lys Gly Tyr Val Gly Glu Thr Pro Tyr485 490 495atg aaa acc ggc agt tca tgg tgg ttg atg ggc ata ttg acc cta gcc1536Met Lys Thr Gly Ser Ser Trp Trp Leu Met Gly Ile Leu Thr Leu Ala500 505 510gca ctg att ctt ttc atc ttc cga aac aaa gaa cac1572Ala Leu Ile Leu Phe Ile Phe Arg Asn Lys Glu His515 520<210>148<211>524<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>148Met Phe Arg Arg Tyr Leu Pro Asn Arg Gln Met Asn Met Val Ser Lys
1 5 10 15Leu Asp Lys Tyr Trp Gln His Pro Ala Leu Tyr Trp Pro Leu Leu Ile20 25 30Leu Phe Ala Ala Ala Thr Pro Phe Thr Phe Ala Pro Tyr Tyr His Phe35 40 45Trp Leu Met Pro Leu Ile Phe Gly Ala Phe Val Arg Leu Ile Glu Leu50 55 60Arg Pro Arg Phe Ala Val Ser Ser Ala Tyr Leu Phe Gly Leu Thr Ala65 70 75 80Tyr Thr Thr Gln Phe Tyr Trp Ile His Thr Ala Leu His Asp Val Ser85 90 95Gly Leu Pro Asp Leu Tyr Ala Val Pro Leu Thr Phe Leu Leu Pro Ala100 105 110Tyr Leu Ala Leu Tyr Pro Ala Leu Cys Phe Trp Leu Trp Lys Lys Phe115 120 125Thr Leu Pro Arg Gly Ile Lys Ile Gly Leu Val Leu Pro Ile Leu Trp130 135 140Thr Leu Thr Glu Phe Ala Arg Glu Arg Phe Leu Thr Gly Phe Gly Trp145 150 155 160Gly Ala Ile Gly Tyr Ser Gln Ile Thr Pro Asp Ser Pro Leu Ala Gly165 170 175Phe Ala Pro Phe Gly Gly Ile His Met Val Thr Leu Ala Thr Ala Phe180 185 190Leu Gly Val Trp Leu Val Leu Ala Ser Asp Asn Thr Ala Arg Ser Gly195 200 205Lys Arg Leu Leu Pro Ile Ile Leu Ile Ala Ala Leu Leu Ala Ala Gly210 215 220Tyr Thr Ala Arg Gln Thr Asp Phe Thr Arg Pro Asp Gly Ser Arg Ser225 230 235 240Thr Val Ala Leu Leu Gln Gly Asn Ile Asp Gln Thr Leu Lys Trp Arg245 250 255Glu Asp Gln Val Ile Pro Thr Ile Gln Lys Tyr Tyr Glu Gln Val Gly
260 265 270Lys Thr Thr Ala Asp Ile Val Ile Leu Pro Glu Thr Ala Ile Pro Val275 280 285Met Arg Gln Asn Leu Pro Glu Asn Ile Leu Ala Lys Phe Ala Glu Gln290 295 300Ala Gln Asn Asn Gly Ser Ala Leu Ala Val Gly Ile Ser Gln Tyr Thr305 310 315 320Ser Asp Gly Asn Gly Tyr Glu Asn Ala Val Ile Asn Leu Thr Gly Tyr325 330 335Gln Glu Asn Asn Gln Asp Gly Ile Pro Tyr Tyr Ala Lys Asn His Leu340 345 350Val Pro Phe Gly Glu Tyr Lys Pro Leu Pro Phe Leu Thr Thr Pro Leu355 360 365Tyr Lys Met Met Asn Met Pro Leu Ser Asp Phe Arg Lys Gly Gly Gly370 375 380Lys Gln Ser Ala Leu Leu Met Lys Asn Gln Lys Ile Ala Phe Asn Ile385 390 395 400Cys Tyr Glu Asp Gly Phe Gly Asp Glu Leu Ile Ala Ala Ala Lys Asp405 410 415Ala Thr Leu Leu Ala Asn Ala Ser Asn Met Ala Trp Tyr Gly Lys Ser420 425 430Asn Ala Met Tyr Gln His Leu Gln Gln Ser Gln Ala Arg Ala Met Glu435 440 445Leu Gly Arg Tyr Met Val Arg Ala Thr Asn Thr Gly Ala Thr Ala Ile450 455 460Ile Ser Pro Lys Gly Asn Ile Ile Ala Gln Ala Gln Pro Asp Thr Glu465 470 475 480Thr Val Leu Glu Gly His Ile Lys Gly Tyr Val Gly Glu Thr Pro Tyr485 490 495Met Lys Thr Gly Ser Ser Trp Trp Leu Met Gly Ile Leu Thr Leu Ala500 505 510Ala Leu Ile Leu Phe Ile Phe Arg Asn Lys Glu His
515 520<210>149<211>558<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(558)<400>149ttg gat ctc tac aaa ctc ggt tac aaa caa cat acc cgt acc gat gcg48Leu Asp Leu Tyr Lys Leu Gly Tyr Lys Gln His Thr Arg Thr Asp Ala1 5 10 15gaa ggc tat atc gag aaa ctg cac att acc ccc gcc aat gcc cat gag96Glu Gly Tyr Ile Glu Lys Leu His Ile Thr Pro Ala Asn Ala His Glu20 25 30tgc aaa cac ctg ccg ccg ttg ttg gaa gga ctg ccc aaa ggt acg acc144Cys Lys His Leu Pro Pro Leu Leu Glu Gly Leu Pro Lys Gly Thr Thr35 40 45gtc tat gcc gac aaa ggc tac gac agt gcg gaa aac cgg caa cat ctg192Val Tyr Ala Asp Lys Gly Tyr Asp Ser Ala Glu Asn Arg Gln His Leu50 55 60gaa gaa cat cag ttg ttg gac ggc att atg cgc aaa gcc tgc cgc aac240Glu Glu His Gln Leu Leu Asp Gly Ile Met Arg Lys Ala Cys Arg Asn65 70 75 80cgt ccg ctg tcg gaa acg caa acc aaa cgc aac cgg tat ttg tcg aag288Arg Pro Leu Ser Glu Thr Gln Thr Lys Arg Asn Arg Tyr Leu Ser Lys85 90 95acc cgt tat agt gga tta aat tta aat cag gac aag gcg acg aag ccg336Thr Arg Tyr Ser Gly Leu Asn Leu Asn Gln Asp Lys Ala Thr Lys Pro100 105 110cag aca gta caa ata gta cgg caa ggc gag gca acg ccg tac tgg ttt384Gln Thr Val Gln Ile Val Arg Gln Gly Glu Ala Thr Pro Tyr Trp Phe115 120 125aaa ttt aat cca cta tat gtg gtc gaa cag agc ttc ggt acg ctg cac432Lys Phe Asn Pro Leu Tyr Val Val Glu Gln Ser Phe Gly Thr Leu His
130 135 140cgt aaa ttc cgc tat gcg cgg gca gcc tat ttc gga ctg att aaa gtg480Arg Lys Phe Arg Tyr Ala Arg Ala Ala Tyr Phe Gly Leu Ile Lys Val145 150 155 160agt gcg caa agc cat ctg aag gcg atg tgt ttg aac ctg ttg aaa gcc528Ser Ala Gln Ser His Leu Lys Ala Met Cys Leu Asn Leu Leu Lys Ala165 170 175gcc aac aag cta agt gcg ccc gct gcc gcc558Ala Asn Lys Leu Ser Ala Pro Ala Ala Ala180 185<210>150<211>186<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>150Leu Asp Leu Tyr Lys Leu Gly Tyr Lys Gln His Thr Arg Thr Asp Ala1 5 10 15Glu Gly Tyr Ile Glu Lys Leu His Ile Thr Pro Ala Asn Ala His Glu20 25 30Cys Lys His Leu Pro Pro Leu Leu Glu Gly Leu Pro Lys Gly Thr Thr35 40 45Val Tyr Ala Asp Lys Gly Tyr Asp Ser Ala Glu Asn Arg Gln His Leu50 55 60Glu Glu His Gln Leu Leu Asp Gly Ile Met Arg Lys Ala Cys Arg Asn65 70 75 80Arg Pro Leu Ser Glu Thr Gln Thr Lys Arg Asn Arg Tyr Leu Ser Lys85 90 95Thr Arg Tyr Ser Gly Leu Asn Leu Asn Gln Asp Lys Ala Thr Lys Pro100 105 110Gln Thr Val Gln Ile Val Arg Gln Gly Glu Ala Thr Pro Tyr Trp Phe115 120 125Lys Phe Asn Pro Leu Tyr Val Val Glu Gln Ser Phe Gly Thr Leu His130 135 140
Arg Lys Phe Arg Tyr Ala Arg Ala Ala Tyr Phe Gly Leu Ile Lys Val145 150 155 160Ser Ala Gln Ser His Leu Lys Ala Met Cys Leu Asn Leu Leu Lys Ala165 170 175Ala Asn Lys Leu Ser Ala Pro Ala Ala Ala180 185<210>151<211>1332<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1332)<400>151atg act gac ctg aac acc ctg ttt gcc aac ctc aaa caa cgc aat ccc48Met Thr Asp Leu Asn Thr Leu Phe Ala Asn Leu Lys Gln Arg Asn Pro1 5 10 15aat cag gag ccg ttc cat cag gcg gtt gaa gaa gtc ttc atg agt ctc96Asn Gln Glu Pro Phe His Gln Ala Val Glu Glu Val Phe Met Ser Leu20 25 30gat ccg ttt ttg gca aaa aat ccg aaa tac acc cag caa agc ctg ctg144Asp Pro Phe Leu Ala Lys Asn Pro Lys Tyr Thr Gln Gln Ser Leu Leu35 40 45gaa cgc atc gtc gaa ccc gaa cgc gtc gtg atg ttc cgc gta acc tgg192Glu Arg Ile Val Glu Pro Glu Arg Val Val Met Phe Arg Val Thr Trp50 55 60cag gac gat aaa ggg caa gtc caa gtc aac cgg ggc tac cgc gtg caa240Gln Asp Asp Lys Gly Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln65 70 75 80atg agt tcc gcc atc ggt cct tac aaa ggc ggc ctg cgc ttc cat ccg288Met Ser Ser Ala Ile Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro85 90 95acc gtc gat ttg ggc gta ttg aaa ttc ctc gct ttt gaa caa gtg ttc336Thr Val Asp Leu Gly Val Leu Lys Phe Leu Ala Phe Glu Gln Val Phe100 105 110
aaa aac gcc ttg acc acc ctg cct atg ggc ggc ggc aaa ggc ggt tcc384Lys Asn Ala Leu Thr Thr Leu Pro Met Gly Gly Gly Lys Gly Gly Ser115 120 125gac ttc gac ccc aaa ggc aaa tcc gat gcc gaa gta atg cgc ttc tgc432Asp Phe Asp Pro Lys Gly Lys Ser Asp Ala Glu Val Met Arg Phe Cys130 135 140caa gcc ttt atg acc gaa ctc tac cgc cac atc ggc gcg gac acc gat480Gln Ala Phe Met Thr Glu Leu Tyr Arg His Ile Gly Ala Asp Thr Asp145 150 155 160gtt ccg gcc ggc gac atc ggc gta ggc ggg cgc gaa atc ggc tac ctg528Val Pro Ala Gly Asp Ile Gly Val Gly Gly Arg Glu Ile Gly Tyr Leu165 170 175ttc gga caa tac aaa aaa atc cgc aac gag ttt tct tcc gtc ctg acc576Phe Gly Gln Tyr Lys Lys Ile Arg Asn Glu Phe Ser Ser Val Leu Thr180 185 190ggc aaa ggt ttg gaa tgg ggc ggc agc ctc atc cgt ccc gaa gcg acc624Gly Lys Gly Leu Glu Trp Gly Gly Ser Leu Ile Arg Pro Glu Ala Thr195 200 205ggc tac ggc tgc gtc tat ttc gcc caa gcg atg ctg caa acc cgc aac672Gly Tyr Gly Cys Val Tyr Phe Ala Gln Ala Met Leu Gln Thr Arg Asn210 215 220gat agt ttt gaa ggc aaa cgc gtc ctg att tcc ggt tcc ggc aac gtg720Asp Ser Phe Glu Gly Lys Arg Val Leu Ile Ser Gly Ser Gly Asn Val225 230 235 240gcg caa tac gcc gcc gaa aaa gcc atc caa ctg ggc gcg aaa gtg ctg768Ala Gln Tyr Ala Ala Glu Lys Ala Ile Gln Leu Gly Ala Lys Val Leu245 250 255acc gtt tcc gac tcc aac ggc ttc gtc ctc ttc ccc gac agc ggt atg816Thr Val Ser Asp Ser Asn Gly Phe Val Leu Phe Pro Asp Ser Gly Met260 265 270agc gaa gcg caa ctc gcc gcc ttg atc gaa ttg aaa gaa gtc cgc cgc864Ser Glu Ala Gln Leu Ala Ala Leu Ile Glu Leu Lys Glu Val Arg Arg275 280 285gaa cgg gtt gcc acc tac gcc aaa gag caa ggt ctg caa tac ttt gaa912Glu Arg Val Ala Thr Tyr Ala Lys Glu Gln Gly Leu Gln Tyr Phe Glu290 295 300
aac caa aaa ccg tgg ggc gtc gcc gcc gaa atc gcc ctg ccc tgc gcg960Asn Gln Lys Pro Trp Gly Val Ala Ala Glu Ile Ala Leu Pro Cys Ala305 310 315 320acc cag aac gaa ttg gac gaa gaa gcc gcc aaa acc ctg ttg gca aac1008Thr Gln Asn Glu Leu Asp Glu Glu Ala Ala Lys Thr Leu Leu Ala Asn325 330 335ggc tgc tac gtc gtt gcc gaa ggt gcg aat atg ccg tcg act ttg ggc1056Gly Cys Tyr Val Val Ala Glu Gly Ala Asn Met Pro Ser Thr Leu Gly340345 350gcg gtc gag caa ttt atc aaa gcc ggc atc ctc tac gcc ccg ggc aaa1104Ala Val Glu Gln Phe Ile Lys Ala Gly Ile Leu Tyr Ala Pro Gly Lys355 360 365gcc tcc aac gcc ggc ggc gta gca act tca ggt ttg gaa atg agc caa1152Ala Ser Asn Ala Gly Gly Val Ala Thr Ser Gly Leu Glu Met Ser Gln370 375 380aac gcc atc cgc ctg tct tgg act cgt gaa gaa gtc gac caa cgc ctg1200Asn Ala Ile Arg Leu Ser Trp Thr Arg Glu Glu Val Asp Gln Arg Leu385 390 395 400ttc ggc atc atg caa agc atc cac gaa tcc tgt ctg aaa tac ggc aaa1248Phe Gly Ile Met Gln Ser Ile His Glu Ser Cys Leu Lys Tyr Gly Lys405 410 415gtc ggc gac aca gta aac tac gtc aat ggt gcg aac att gcc ggt ttc1296Val Gly Asp Thr Val Asn Tyr Val Asn Gly Ala Asn Ile Ala Gly Phe420 425 430gtc aaa gtt gcc gat gcg atg ctg gcg caa ggc ttc1332Val Lys Val Ala Asp Ala Met Leu Ala Gln Gly Phe435 440<210>152<211>444<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>152Met Thr Asp Leu Asn Thr Leu Phe Ala Asn Leu Lys Gln Arg Asn Pro1 5 10 15Asn Gln Glu Pro Phe His Gln Ala Val Glu Glu Val Phe Met Ser Leu
20 25 30Asp Pro Phe Leu Ala Lys Asn Pro Lys Tyr Thr Gln Gln Ser Leu Leu35 40 45Glu Arg Ile Val Glu Pro Glu Arg Val Val Met Phe Arg Val Thr Trp50 55 60Gln Asp Asp Lys Gly Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln65 70 75 80Met Ser Ser Ala Ile Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro85 90 95Thr Val Asp Leu Gly Val Leu Lys Phe Leu Ala Phe Glu Gln Val Phe100 105 110Lys Asn Ala Leu Thr Thr Leu Pro Met Gly Gly Gly Lys Gly Gly Ser115 120 125Asp Phe Asp Pro Lys Gly Lys Ser Asp Ala Glu Val Met Arg Phe Cys130 135 140Gln Ala Phe Met Thr Glu Leu Tyr Arg His Ile Gly Ala Asp Thr Asp145 150 155 160Val Pro Ala Gly Asp Ile Gly Val Gly Gly Arg Glu Ile Gly Tyr Leu165 170 175Phe Gly Gln Tyr Lys Lys Ile Arg Asn Glu Phe Ser Ser Val Leu Thr180 185 190Gly Lys Gly Leu Glu Trp Gly Gly Ser Leu Ile Arg Pro Glu Ala Thr195 200 205Gly Tyr Gly Cys Val Tyr Phe Ala Gln Ala Met Leu Gln Thr Arg Asn210 215 220Asp Ser Phe Glu Gly Lys Arg Val Leu Ile Ser Gly Ser Gly Asn Val225 230 235 240Ala Gln Tyr Ala Ala Glu Lys Ala Ile Gln Leu Gly Ala Lys Val Leu245 250 255Thr Val Ser Asp Ser Asn Gly Phe Val Leu Phe Pro Asp Ser Gly Met260 265 270Ser Glu Ala Gln Leu Ala Ala Leu Ile Glu Leu Lys Glu Val Arg Arg
275 280 285Glu Arg Val Ala Thr Tyr Ala Lys Glu Gln Gly Leu Gln Tyr Phe Glu290 295 300Asn Gln Lys Pro Trp Gly Val Ala Ala Glu Ile Ala Leu Pro Cys Ala305 310 315 320Thr Gln Asn Glu Leu Asp Glu Glu Ala Ala Lys Thr Leu Leu Ala Asn325 330 335Gly Cys Tyr Val Val Ala Glu Gly Ala Asn Met Pro Ser Thr Leu Gly340 345 350Ala Val Glu Gln Phe Ile Lys Ala Gly Ile Leu Tyr Ala Pro Gly Lys355 360 365Ala Ser Asn Ala Gly Gly Val Ala Thr Ser Gly Leu Glu Met Ser Gln370 375 380Asn Ala Ile Arg Leu Ser Trp Thr Arg Glu Glu Val Asp Gln Arg Leu385 390 395 400Phe Gly Ile Met Gln Ser Ile His Glu Ser Cys Leu Lys Tyr Gly Lys405 410 415Val Gly Asp Thr Val Asn Tyr Val Asn Gly Ala Asn Ile Ala Gly Phe420 425 430Val Lys Val Ala Asp Ala Met Leu Ala Gln Gly Phe435 440<210>153<211>867<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(867)<400>153atg aaa ccc ata cgg aaa gcc gtc ttc ccc gtc gca ggg atg gga aca48Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr1 5 10 15
cgc ttc ctg ccc gcc acc aag gca agc ccg aaa gaa atg ctg ccc atc96Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile20 25 30gtc gac aag ccg ctg atc caa tac gcc gta gaa gaa gcc gtg gaa gcc144Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Glu Ala35 40 45ggc tgc acg gaa atg gtg ttt gtt acc gga cgc aac aaa cgc agc atc192Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile50 55 60gaa gac cat ttc gac aag gca tac gaa ctc gaa acc gag ttg gaa atg240Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met65 70 75 80cgc cat aaa gac aaa ttg ttg gaa cac gtc cgc aac atc ctg ccg ccg288Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro85 90 95aac att acc tgc ctc tac atc cgt cag gcg gaa gca ctg ggc ttg gga336Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly100 105 110cac gcc gtc ttg tgc gcc cgc gcc gcc atc ggc gac gaa ccc ttt gcc384His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala115 120 125gtg att ttg gct gac gat tta atc gat gcc caa aaa ggc gcg ctc aaa432Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys130 135 140caa atg gtc gaa gtg tac gaa cgc agc ggc aac agc att ttg ggc gta480Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val145 150 155 160gaa act gtc gaa ccg tcg caa acc ggc tca tac ggc atc gtc gaa acc528Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr165 170 175gaa cag ctc aaa cag ttc caa cgc att acc ggc att gtc gaa aaa ccc576Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro180 185 190aag ccc gaa gac gcg ccc tcc aac ctt gcc gtc gtc gga cgc tac atc624Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile195 200 205
ctt acc ccg cgc att ttc gac tta ctg acc gga ctg ccg cgc ggc gcg672Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala210 215 220ggc aac gaa atc cag ctt aca gac ggc atc gcc aag ctg ctc gat cac720Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His225 230 235 240gaa ttt gtc cta gcg cac ccc ttt gaa ggc acg cgc tac gac tgc ggc768Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly245 250 255agc aaa ctg ggc tat ctg gaa gcc acc gtc gcc tac ggc ctg aaa cac816Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His260 265 270ccc gaa acc ggc gaa ccc ttc cgc cgc ctt ttg gaa aaa tac cgt acc864Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr275 280 285gaa867Glu<210>154<211>289<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>154Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr1 5 10 15Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile20 25 30Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Glu Ala35 40 45Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile50 55 60Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met65 70 75 80Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro85 90 95
Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly100 105 110His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala115 120 125Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys130 135 140Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val145 150 155 160Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr165 170 175Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro180 185 190Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile195 200 205Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala210 215 220Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His225 230 235 240Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly245 250 255Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His260 265 270Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr275 280 285Glu<210>155<211>876<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS
<222>(1)..(876)<400>155ttg acc gtc cga acg aaa aag acg gcg cat tat acc cta ttc cat tcc 48Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser1 5 10 15gac cga aaa ccg aac atg act act ctc aaa ccc gcc ctg ccc gct tat 96Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr20 25 30ctg gac aac atc cgc atc atc ctc acg cgc acc agc cat ccc gcc aac144Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn35 40 45atc ggc tct gcc gcg cgc gcg atg aaa aca atg ggt ctg cac aaa ctg192Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu50 55 60acc atc gtc gcc cca aat ctg atg gca acg ccg atg acg gaa aac ccg240Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro65 70 75 80ccc gtg ttt gac ccg gag cat cct caa tcg ttt aaa tta ccg gaa gaa288Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu85 90 95agc ttc atc ctc gct tcc ggc gcg gca gac gtt ttg gaa aat gcc acc336Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr100 105 110att gcc gct tct ttg gac gaa gcc ctt gcc gac acc acc atc gcc tgc384Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys115 120 125gcc ctg acc agc cgc cgc cgc gaa att act gcg ccg ctg caa acc ccg432Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro130 135 140cgc gat ttg gta tcc gaa tta ctg cag acc gca aac cga ggc gag aaa480Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys145 150 155 160gtg gca ctg gtt ttc ggc aac gag act ttc ggc ttg agc atc gaa gaa528Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu165 170 175gtc caa gcc tgc aac cga ctg atg acc atc aac ggc aat ccc gac tat576
Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr180 185 190ttc tcg ctc aac ctc gcc caa gcc gtg cag gtc gtg tgc tac gaa atc624Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile195 200 205ttc agc caa acc ggt tcg ccc atg acc cat ctt caa caa gaa gac cac672Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His210 215 220gct gcg acc cac gag caa atc aaa ggc atg gtc gcc cac atg gaa agc720Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser225 230 235 240gtg atg aac gac atc ggc ttt ttc aac cgc cgc aac ggc gag cgt ctg768Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu245 250 255atg cgc cgt atg cag agc ctg ttc gga cgc gcc aac acg caa acc gaa816Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu260 265 270gac atc gat atc ctg cgc ggt ttt ttc aat acc gtc agc cat cgt atc864Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile275 280 285cat aaa aaa gac876His Lys Lys Asp290<210>156<211>292<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>156Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser1 5 10 15Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr20 25 30Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn35 40 45Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu
50 55 60Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro65 70 75 80Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu85 90 95Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr100 105 110Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys115 120 125Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro130 135 140Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys145 150 155 160Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu165 170 175Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr180 185 190Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile195 200 205Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His210 215 220Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser225 230 235 240Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu245 250 255Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu260 265 270Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile275 280 285His Lys Lys Asp290
<210>157<211>1008<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1008)<400>157atg tcc atc aaa atc ctg att att tcc ccc agt tgg ata ggc gac tgc48Met Ser Ile Lys Ile Leu Ile Ile Ser Pro Ser Trp Ile Gly Asp Cys1 5 10 15gtg atg acc cag ccc ttg ttc cgc cgt ttg aag gaa ctt cac ccc ggt96Val Met Thr Gln Pro Leu Phe Arg Arg Leu Lys Glu Leu His Pro Gly20 25 30tgc acg att gat gtg ttc gca ccg aag tgg tcg atg gcg gtg ttt gag144Cys Thr Ile Asp Val Phe Ala Pro Lys Trp Ser Met Ala Val Phe Glu35 40 45cgt atg ccg gaa gtg aat gag att ctt gaa aat ccg ttc gga cac ggt192Arg Met Pro Glu Val Asn Glu Ile Leu Glu Asn Pro Phe Gly His Gly50 55 60gcg ttg gag ttg aaa cgc cgt tgg cgg gtc ggt agg gat ttg ggg cgg240Ala Leu Glu Leu Lys Arg Arg Trp Arg Val Gly Arg Asp Leu Gly Arg65 70 75 80cgc gga tac gat cag gtt atc gtg ttg ccc ggt tct ttg aaa tcg gca288Arg Gly Tyr Asp Gln Val Ile Val Leu Pro Gly Ser Leu Lys Ser Ala85 90 95atc atc gcg ctg gcg aca ggt atc ggt aaa agg acg ggt tat gtc ggt336Ile Ile Ala Leu Ala Thr Gly Ile Gly Lys Arg Thr Gly Tyr Val Gly100 105 110gaa agc cgt tat ttt ctg ttg aac gat ata cgc agg ctg gat aag gaa384Glu Ser Arg Tyr Phe Leu Leu Asn Asp Ile Arg Arg Leu Asp Lys Glu115 120 125cgt ctg cct ttg atg gtg gac aga tat acg gct ctc gcg cat ccg agc432Arg Leu Pro Leu Met Val Asp Arg Tyr Thr Ala Leu Ala His Pro Ser130 135 140cag gag gat ttt gac ggg cat tcg gga ttc ccc gag ttt tcc att gat480
Gln Glu Asp Phe Asp Gly His Ser Gly Phe Pro Glu Phe Ser Ile Asp145 150 155 160gaa cgg cgg cgg gaa att tct gtc gaa acc ttt ggc ttg gat att gga528Glu Arg Arg Arg Glu Ile Ser Val Glu Thr Phe Gly Leu Asp Ile Gly165 170 175aag cct gtt ctg gct ttt tgt ccg ggt gcg gaa ttc ggg ccg gca aag576Lys Pro Val Leu Ala Phe Cys Pro Gly Ala Glu Phe Gly Pro Ala Lys180 185 190cgt tgg ccg aca agg tat ttt gcc gag ttg ggc aaa cat tat tcg gcg624Arg Trp Pro Thr Arg Tyr Phe Ala Glu Leu Gly Lys His Tyr Ser Ala195 200 205gcg ggt tgg cag gtt tgg ctg ttc ggt tcg caa aaa gat gat gaa att672Ala Gly Trp Gln Val Trp Leu Phe Gly Ser Gln Lys Asp Asp Glu Ile210 215 220gcc gag gaa atc aac tgc ctt tca gac ggt atg tgt gtc aat ttg tgc720Ala Glu Glu Ile Asn Cys Leu Ser Asp Gly Met Cys Val Asn Leu Cys225 230 235 240ggc aaa acc gat ttg tcg cag gca atg gat ttg ctg tcg ttg gcg gac768Gly Lys Thr Asp Leu Ser Gln Ala Met Asp Leu Leu Ser Leu Ala Asp245 250 255acg gtc gtg tgc aac gac agc ggg ctg atg cac ttg gcg gcg gca ttg816Thr Val Val Cys Asn Asp Ser Gly Leu Met His Leu Ala Ala Ala Leu260 265 270ggc agg aag gtg gtg gcg gtt tac ggt tct tcc agc ccg acg cat acg864Gly Arg Lys Val Val Ala Val Tyr Gly Ser Ser Ser Pro Thr His Thr275 280 285ccg cct ttg agc gac agg gcg aaa atc gtc agc ctg cac ttg gaa tgt912Pro Pro Leu Ser Asp Arg Ala Lys Ile Val Ser Leu His Leu Glu Cys290 295 300tcg ccc tgt ttt aag cgg gaa tgt ccg ctg ggg cat acc gac tgc ctc960Ser Pro Cys Phe Lys Arg Glu Cys Pro Leu Gly His Thr Asp Cys Leu305 310 315 320aac agg ctg tat ccc gag aag att gtg cag gcg gtt gaa gag gcg gta1008Asn Arg Leu Tyr Pro Glu Lys Ile Val Gln Ala Val Glu Glu Ala Val325 330 335
<210>158<211>336<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>158Met Ser Ile Lys Ile Leu Ile Ile Ser Pro Ser Trp Ile Gly Asp Cys1 5 10 15Val Met Thr Gln Pro Leu Phe Arg Arg Leu Lys Glu Leu His Pro Gly20 25 30Cys Thr Ile Asp Val Phe Ala Pro Lys Trp Ser Met Ala Val Phe Glu35 40 45Arg Met Pro Glu Val Asn Glu Ile Leu Glu Asn Pro Phe Gly His Gly50 55 60Ala Leu Glu Leu Lys Arg Arg Trp Arg Val Gly Arg Asp Leu Gly Arg65 70 75 80Arg Gly Tyr Asp Gln Val Ile Val Leu Pro Gly Ser Leu Lys Ser Ala85 90 95Ile Ile Ala Leu Ala Thr Gly Ile Gly Lys Arg Thr Gly Tyr Val Gly100 105 110Glu Ser Arg Tyr Phe Leu Leu Asn Asp Ile Arg Arg Leu Asp Lys Glu115 120 125Arg Leu Pro Leu Met Val Asp Arg Tyr Thr Ala Leu Ala His Pro Ser130 135 140Gln Glu Asp Phe Asp Gly His Ser Gly Phe Pro Glu Phe Ser Ile Asp145 150 155 160Glu Arg Arg Arg Glu Ile Ser Val Glu Thr Phe Gly Leu Asp Ile Gly165 170 175Lys Pro Val Leu Ala Phe Cys Pro Gly Ala Glu Phe Gly Pro Ala Lys180 185 190Arg Trp Pro Thr Arg Tyr Phe Ala Glu Leu Gly Lys His Tyr Ser Ala195 200 205Ala Gly Trp Gln Val Trp Leu Phe Gly Ser Gln Lys Asp Asp Glu Ile210 215 220
Ala Glu Glu Ile Asn Cys Leu Ser Asp Gly Met Cys Val Asn Leu Cys225 230 235 240Gly Lys Thr Asp Leu Ser Gln Ala Met Asp Leu Leu Ser Leu Ala Asp245 250 255Thr Val Val Cys Asn Asp Ser Gly Leu Met His Leu Ala Ala Ala Leu260 265 270Gly Arg Lys Val Val Ala Val Tyr Gly Ser Ser Ser Pro Thr His Thr275 280 285Pro Pro Leu Ser Asp Arg Ala Lys Ile Val Ser Leu His Leu Glu Cys290 295 300Ser Pro Cys Phe Lys Arg Glu Cys Pro Leu Gly His Thr Asp Cys Leu305 310 315 320Asn Arg Leu Tyr Pro Glu Lys Ile Val Gln Ala Val Glu Glu Ala Val325 330 335<210>159<211>381<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(381)<400>159atg gaa cct tcc tcc tac gcg gca gaa aaa aaa gga aaa ggc ggc atc48Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile1 5 10 15agg cgc gtc atc aac gca ttc ggc tat tcg ata gac ggc atc gcc gcc96Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala20 25 30gcc tac cgt tac gaa gcg gca ttc cgt cag gtt ttg tgg ctg aac gcg144Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala35 40 45ctg ctg gtg tgc gcg gca ttt ttt tgg gtt tcc gaa aag tcc ctc cgc192Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg50 55 60
ctg ccg ttg att atc gcg tct ttt gtg tcg gtc att gtc gaa ctg ttc240Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe65 70 75 80aac act gcc gtc gaa gcc gcc gtc gat cat act tcg act gaa aaa cac288Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His85 90 95gag ctg gct aaa cgc gcc aaa gac gca ggt tct gct gca cra ttg ttc336Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe100 105 110gcg atg ctg atg tta gcg gcg gtt tgg ctg tcc gcc ctg ttc ggg381Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly115 120 125<210>160<211>127<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>160Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile1 5 10 15Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala20 25 30Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala35 40 45Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg50 55 60Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe65 70 75 80Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His85 90 95Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe100 105 110Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly115 120 125
<210>161<211>990<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(990)<400>161atg aaa aaa gaa agc cgc ccc gcg ttt gac gcg gca gcc gta ttt gac48Met Lys Lys Glu Ser Arg Pro Ala Phe Asp Ala Ala Ala Val Phe Asp1 5 10 15gcg gca gcc gta ccg gta tcc gac agc ggg ttt gcc gcc aat gca aat96Ala Ala Ala Val Pro Val Ser Asp Ser Gly Phe Ala Ala Asn Ala Asn20 25 30gtc cgc cgt ttt gtg gac gat gaa gtc ggg aaa ggg gat ttt tcc cgg144Val Arg Arg Phe Val Asp Asp Glu Val Gly Lys Gly Asp Phe Ser Arg35 40 45gcg gaa tgg cag gat ttt ttt gac aaa gcg gct tac aag gcg gac atc192Ala Glu Trp Gln Asp Phe Phe Asp Lys Ala Ala Tyr Lys Ala Asp Ile50 55 60gtc aag att atg cac cgc ccc tcc aca tcg cgt ccg tgg tat gtg ttc240Val Lys Ile Met His Arg Pro Ser Thr Ser Arg Pro Trp Tyr Val Phe65 70 75 80cgc acg gga aat tcg ggc aag gcg aaa ttt cgc ggc gcg cgc cgg ttt288Arg Thr Gly Asn Ser Gly Lys Ala Lys Phe Arg Gly Ala Arg Arg Phe85 90 95tat gcg gaa aac cgc gcg ctt atc gat gat gtg gcg caa aaa tac ggc336Tyr Ala Glu Asn Arg Ala Leu Ile Asp Asp Val Ala Gln Lys Tyr Gly100 105 110gtg cct gcc gaa ctt atc gtg gcg gtt atc ggg att gaa acg aat tac384Val Pro Ala Glu Leu Ile Val Ala Val Ile Gly Ile Glu Thr Asn Tyr115 120 125ggc aaa aat acg ggc agt ttc cgt gtg gcg gac gca ttg gcg acc tta432Gly Lys Asn Thr Gly Ser Phe Arg Val Ala Asp Ala Leu Ala Thr Leu130 135 140
ggc ttt gat tac ccc cgc cgc gcc ggg ttt ttc caa aaa gaa ttg gtc480Gly Phe Asp Tyr Pro Arg Arg Ala Gly Phe Phe Gln Lys Glu Leu Val145 150 155 160gag ctt tta aag ctg gca aaa gaa gaa ggc ggc gat gtt ttc gcc ttt528Glu Leu Leu Lys Leu Ala Lys Glu Glu Gly Gly Asp Val Phe Ala Phe165 170 175aaa ggc agc tat gcg ggc gca atg ggg atg ccg caa ttt atg cct tcg576Lys Gly Ser Tyr Ala Gly Ala Met Gly Met Pro Gln Phe Met Pro Ser180 185 190agc tac cgg aaa tgg gcg gtg gat tat gac ggg gac gga cat cgg gac624Ser Tyr Arg Lys Trp Ala Val Asp Tyr Asp Gly Asp Gly His Arg Asp195 200 205ata tgg ggc aat gtt ggc gat gtc gcg gca tcg att gcc aat tat atg672Ile Trp Gly Asn Val Gly Asp Val Ala Ala Ser Ile Ala Asn Tyr Met210 215 220aag cag cac ggt tgg cgc acg ggc ggg aaa ata ctg gtg tct gca aca720Lys Gln His Gly Trp Arg Thr Gly Gly Lys Ile Leu Val Ser Ala Thr225 230 235 240ttg gcg ccg ggt gcg gat gtt cag gca atc att ggc gaa aaa acc gcc768Leu Ala Pro Gly Ala Asp Val Gln Ala Ile Ile Gly Glu Lys Thr Ala245 250 255ctg acg cgg acg gtg gcg gat ttg aag gcg tac ggc atc atc ccc ggc816Leu Thr Arg Thr Val Ala Asp Leu Lys Ala Tyr Gly Ile Ile Pro Gly260 265 270gaa gag ctt gcc gat gat gaa aag gcg gtt ttg ttc aaa ctg gaa acc864Glu Glu Leu Ala Asp Asp Glu Lys Ala Val Leu Phe Lys Leu Glu Thr275 280 285gca ccc ggc gtg ttt gaa tat tat ttg ggc ttg aac aat ttt tat acg912Ala Pro Gly Val Phe Glu Tyr Tyr Leu Gly Leu Asn Asn Phe Tyr Thr290 295 300gta tgg cag tac aat cac agt cgg atg tat gta acg gcg gtc agg gac960Val Trp Gln Tyr Asn His Ser Arg Met Tyr Val Thr Ala Val Arg Asp305 310 315 320att gcc aat tcg ctt ggc ggc ccg gga ttg990Ile Ala Asn Ser Leu Gly Gly Pro Gly Leu325 330
<210>162<211>330<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>162Met Lys Lys Glu Ser Arg Pro Ala Phe Asp Ala Ala Ala Val Phe Asp1 5 10 15Ala Ala Ala Val Pro Val Ser Asp Ser Gly Phe Ala Ala Asn Ala Asn20 25 30Val Arg Arg Phe Val Asp Asp Glu Val Gly Lys Gly Asp Phe Ser Arg35 40 45Ala Glu Trp Gln Asp Phe Phe Asp Lys Ala Ala Tyr Lys Ala Asp Ile50 55 60Val Lys Ile Met His Arg Pro Ser Thr Ser Arg Pro Trp Tyr Val Phe65 70 75 80Arg Thr Gly Asn Ser Gly Lys Ala Lys Phe Arg Gly Ala Arg Arg Phe85 90 95Tyr Ala Glu Asn Arg Ala Leu Ile Asp Asp Val Ala Gln Lys Tyr Gly100 105 110Val Pro Ala Glu Leu Ile Val Ala Val Ile Gly Ile Glu Thr Asn Tyr115 120 125Gly Lys Asn Thr Gly Ser Phe Arg Val Ala Asp Ala Leu Ala Thr Leu130 135 140Gly Phe Asp Tyr Pro Arg Arg Ala Gly Phe Phe Gln Lys Glu Leu Val145 150 155 160Glu Leu Leu Lys Leu Ala Lys Glu Glu Gly Gly Asp Val Phe Ala Phe165 170 175Lys Gly Ser Tyr Ala Gly Ala Met Gly Met Pro Gln Phe Met Pro Ser180 185 190Ser Tyr Arg Lys Trp Ala Val Asp Tyr Asp Gly Asp Gly His Arg Asp195 200 205Ile Trp Gly Asn Val Gly Asp Val Ala Ala Ser Ile Ala Asn Tyr Met210 215 220
Lys Gln His Gly Trp Arg Thr Gly Gly Lys Ile Leu Val Ser Ala Thr225 230 235 240Leu Ala Pro Gly Ala Asp Val Gln Ala Ile Ile Gly Glu Lys Thr Ala245 250 255Leu Thr Arg Thr Val Ala Asp Leu Lys Ala Tyr Gly Ile Ile Pro Gly260 265 270Glu Glu Leu Ala Asp Asp Glu Lys Ala Val Leu Phe Lys Leu Glu Thr275 280 285Ala Pro Gly Val Phe Glu Tyr Tyr Leu Gly Leu Asn Asn Phe Tyr Thr290 295 300Val Trp Gln Tyr Asn His Ser Arg Met Tyr Val Thr Ala Val Arg Asp305 310 315 320Ile Ala Asn Ser Leu Gly Gly Pro Gly Leu325 330<210>163<211>1773<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1773)<400>163atg agt atc gtg ctg cac ggc gtg gcg gcg ggc aaa ggc att gcc gtc48Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val1 5 10 15ggt tgc gcc cac ctg att gcg cgc ggt acg gag gaa gtg ccg cag tat96Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr20 25 30gat gtt gcg gag gcg gac acc gat gcc gaa gcc gaa cgt ttc gat gcc144Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala35 40 45gcc gtc aaa gcc acg cgc aaa gag ttg gaa cag ctc cgc agc gcg att192Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile
50 55 60ccc gaa aac gcc ccg acc gag ttg ggc gcg ttc atc tcg ctg cac ctg240Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu65 70 75 80atg ctc ttg acc gat gtt acc ttg tcg cgc gaa ccc gtc gat att tta288Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu85 90 95agg gaa caa aaa atc aac gcc gag tgg gca ttg aag cag cag agc gac336Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp100 105 110aaa ctc gcc gcc caa ttc gac aat atg gac gat gcc tat ttg cgc gaa384Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu115 120 125cgc aag cag gat atg ctg caa gtc gtc cgc cgc atc cac aac aac ctg432Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu130 135 140atc ggg cag ggc aac gag ttg gaa gtt gcc gac aac ctg ttt gac gaa480Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu145 150 155 160acc gtt ctg att gca aac gac ctt tcg ccc gcc gac acg gtt ttg ttt528Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe165 170 175aaa gag cag cgc att gcc gcc ttc gtt acc gat gcc ggc ggc ccc acc576Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr180 185 190ggg cat acg gcg att ttg ggc agg agc ttg gac atc ccg tcc gtc gtc624Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val195 200 205ggg ctg cac aac gcg cgc aaa ctg att acc gag ggc gaa acg gtc att672Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile210 215 220gtg gac ggt atc aac ggc gtg ttg att atc gcg ccg gat gag tcg gtg720Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val225 230 235 240ttg aac gaa tac cgc cgc cgt gcc cgc gaa tac cgc agc cac aaa cgc768Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg
245 250255gat ttg aac aag ctc aaa aaa acc gcc gcc gcc acc gct gac ggg gtc816Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val260 265 270tgc atc gag ctt gtg ggc aat ata gaa tcc gcc gaa gac gtg aaa ccg864Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro275 280 285ctg cac aac ctc ggc gca gac ggc atc ggg ctg ttc cgc agc gag ttt912Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe290 295 300ctt tac ctg aac cgc gat acg atg ccg tct gaa gac gag cag tac gaa960Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu305 310 315 320gtg tac agc gcg att gtc aaa aaa atg aaa ggc aaa agc gta acg ata1008Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile325 330 335cgg aca gtc gat ttg ggt gtg gac aaa aac ccg cgc tgg ttc ggg aaa1056Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys340 345 350aac agc acg ccc aac ggc agc ctc aac ccc gcg ctg ggc atg acc ggc1104Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly355 360 365atc cgc ctg tgc ctt gcc gaa ccg gtc atg ttc cgc acc cag atg cgc1152Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg370 375 380gcc atc ctc cgc gcc gcc gcc cac ggc ccc gtg cgg atg atg tgg ccg1200Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro385 390 395 400atg att acc tcc gta tcc gaa gtg cgc cag tgc ctc atc cac ctc gac1248Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp405 410 415acc gcg caa cgc cag ctt gcc gaa cgc ggc gat gcc ttc ggt aaa gtc1296Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val420 425 430ggc atc ggc tgt atg att gaa att ccg tct gcc gcg ctg acc gtc ggc1344Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly
435 440 445agt att ttg aaa ctg gtc gat ttc atc tcc gtc ggt acc aac gac ctg1392Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu450 455 460att caa tac atc ttg tcc gtc gat cgc ggc gac gac agc gtc agc cac1440Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His465 470 475 480ctc tac cag ccc ggc cat ccc gcc gtg ctg aaa atg ctg caa cac gtc1488Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val485 490 495atc cgt acc gcc aac cgc atg gac aaa gac gta tcc gta tgc ggc gag1536Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu500 505 510atg gcg ggc gat acc gcg ttt acc cgc gtt tta ttg ggt atg ggg ctg1584Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu515 520 525cgc cgt ttt tcc atg aac ccc aac aac atc ctg ccc gtc aaa aac atc1632Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile530 535 540att ctg cac agc aat gtc gga cag ctc gaa agc gat att gtg aaa gtc1680Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val545 550 555 560atc cgc tgc gaa gac gaa gag aag tcg gaa aag ctg atc aaa cag atg1728Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met565 570 575aac agc gtg tct gtc gag gaa gaa gcc gac ttc aag ggg cgg aaa1773Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys580 585 590<210>164<211>591<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>164Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val1 5 10 15
Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr20 25 30Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala35 40 45Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile50 55 60Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu65 70 75 80Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu85 90 95Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp100 105 110Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu115 120 125Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu130 135 140Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu145 150 155 160Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe165 170 175Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr180 185 190Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val195 200 205Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile210 215 220Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val225 230 235 240Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg245 250 255Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val260 265 270
Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro275 280 285Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe290 295 300Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu305 310 315 320Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile325 330 335Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys340 345 350Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly355 360 365Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg370 375 380Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro385 390 395 400Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp405 410 415Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val420 425 430Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly435 440 445Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu450 455 460Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His465 470 475 480Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val485 490 495Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu500 505 510Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu515 520 525
Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile530 535 540Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val545 550 555 560Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met565 570 575Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys580 585 590<210>165<211>381<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(381)<400>165atg gaa cct tcc tcc tac gcg gca gaa aaa aaa gga aaa ggc ggc atc48Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile1 5 10 15agg cgc gtc atc aac gca ttc ggc tat tcg ata gac ggc atc gcc gcc96Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala20 25 30gcc tac cgt tac gaa gcg gca ttc cgt cag gtt ttg tgg ctg aac gcg144Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala35 40 45ctg ctg gtg tgc gcg gca ttt ttt tgg gtt tcc gaa aag tcc ctc cgc192Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg50 55 60ctg ccg ttg att atc gcg tct ttt gtg tcg gtc att gtc gaa ctg ttc240Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe65 70 75 80aac act gcc gtc gaa gcc gcc gtc gat cat act tcg act gaa aaa cac288Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His85 90 95
gag ctg gct aaa cgc gcc aaa gac gca ggt tct gct gca caa ttg ttc 336Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe100 105 110gcg atg ctg atg tta gcg gcg gtt tgg ctg tcc gcc ctg ttc ggg 381Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly115 120 125<210>166<211>127<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>166Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile1 5 10 15Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala20 25 30Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala35 40 45Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg50 55 60Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe65 70 75 80Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His85 90 95Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe100 105 110Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly115 120 125<210>167<211>1257<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS
<222>(1)..(1257)<400>167atg agt atg gca ctt gcc caa aaa ctt gcc gcc gac agc att gcg gcg48Met Ser Met Ala Leu Ala Gln Lys Leu Ala Ala Asp Ser Ile Ala Ala1 5 10 15gtt gcc gaa gga cgc aac ctt cag gac gtg ttg gcg caa atc cgc acc96Val Ala Glu Gly Arg Asn Leu Gln Asp Val Leu Ala Gln Ile Arg Thr20 25 30gcg cat ccc gac ctt acg gcg cag gaa aac ggc gcg ttg cag gac atc144Ala His Pro Asp Leu Thr Ala Gln Glu Asn Gly Ala Leu Gln Asp Ile35 40 45gcc tac ggc tgc cag cgt tat ttg ggc agt ttg aaa cat atg ctc gcg192Ala Tyr Gly Cys Gln Arg Tyr Leu Gly Ser Leu Lys His Met Leu Ala50 55 60cag atg ctg aaa aag ccg att ggc aat ccg cag ctc gaa agt ctg ctt240Gln Met Leu Lys Lys Pro Ile Gly Asn Pro Gln Leu Glu Ser Leu Leu65 70 75 80ttg gcg gcg ttg tac caa ctg cat tac acg cgc aac gcg ccg cat gct288Leu Ala Ala Leu Tyr Gln Leu His Tyr Thr Arg Asn Ala Pro His Ala85 90 95gtg gtc aac gaa gct gtt gaa agc atc gcc aaa atc gga cgc ggg cag336Val Val Asn Glu Ala Val Glu Ser Ile Ala Lys Ile Gly Arg Gly Gln100 105 110tac cgt tcg ttt gcc aac gcg att ttg cgc cgc ttt ttg cgc gaa cgc384Tyr Arg Ser Phe Ala Asn Ala Ile Leu Arg Arg Phe Leu Arg Glu Arg115 120 125gac aag ctt gcg gct tcc tgc aaa aaa gac gat gtg gcg aaa cac aac432Asp Lys Leu Ala Ala Ser Cys Lys Lys Asp Asp Val Ala Lys His Asn130 135 140ctg ccg ctg tgg tgg gtg gct tac ttg aaa aac cat tat ccg aaa cac480Leu Pro Leu Trp Trp Val Ala Tyr Leu Lys Asn His Tyr Pro Lys His145 150 155 160tgg cac aac atc gcc gcc gcg ctg caa tcc cat ccg ccg atg acg ttg528Trp His Asn Ile Ala Ala Ala Leu Gln Ser His Pro Pro Met Thr Leu165 170 175cgc gtc aac cgc cga cac ggc aac gcc gaa agc tat ttg gaa aaa ctg576
Arg Val Asn Arg Arg His Gly Asn Ala Glu Ser Tyr Leu Glu Lys Leu180 185 190gct gcg gaa ggc att gcg gca aag gcg ttg gac gaa tat gcg gtt acg624Ala Ala Glu Gly Ile Ala Ala Lys Ala Leu Asp Glu Tyr Ala Val Thr195 200 205ttg gaa gaa gcc gtg ccg gtg aac cgc ctg ccc ggt ttt tca gac ggc672Leu Glu Glu Ala Val Pro Val Asn Arg Leu Pro Gly Phe Ser Asp Gly210 215 220att gtt tcg gta cag gac ttc ggc gcg cag cag gcg gcg tat ctc ctt720Ile Val Ser Val Gln Asp Phe Gly Ala Gln Gln Ala Ala Tyr Leu Leu225 230 235 240aac ccg aaa gac ggc gaa cgg att ttg gac gcg tgc gcc gcg ccg ggc768Asn Pro Lys Asp Gly Glu Arg Ile Leu Asp Ala Cys Ala Ala Pro Gly245 250 255ggc aag acg ggg cat atc ttg gaa ctg gcg gat tgc cgc gtt acc gcc816Gly Lys Thr Gly His Ile Leu Glu Leu Ala Asp Cys Arg Val Thr Ala260 265 270ttg gac att gat gca ggc cgt ctg aag cgt gtg gag gac aat atc gcc864Leu Asp Ile Asp Ala Gly Arg Leu Lys Arg Val Glu Asp Asn Ile Ala275 280 285cgt ttg ggc ttt cag acg gca tcg gcg gcg tgt gcc gat gcg cgg gat912Arg Leu Gly Phe Gln Thr Ala Ser Ala Ala Cys Ala Asp Ala Arg Asp290 295 300ttg gcg gcg tgg tat gat gga aag cct ttc gac aca atc ctt gcc gac960Leu Ala Ala Trp Tyr Asp Gly Lys Pro Phe Asp Thr Ile Leu Ala Asp305 310 315 320gtg cca tgc acc gct tcc ggc gtg gcg cgg cgc aat ccc gac gtg aaa1008Val Pro Cys Thr Ala Ser Gly Val Ala Arg Arg Asn Pro Asp Val Lys325 330 335tgg ctg cgc cgt ccg acc gac gcg ctc aaa acc gcc cgc cag cag gaa1056Trp Leu Arg Arg Pro Thr Asp Ala Leu Lys Thr Ala Arg Gln Gln Glu340 345 350gcc ctg ctg gac gca ctt tgg cag acg ctg aaa cag ggc ggc aga atg1104Ala Leu Leu Asp Ala Leu Trp Gln Thr Leu Lys Gln Gly Gly Arg Met355 360 365ctg ctt gcc acc tgt tcc gtg ttc gtc gaa gaa aac gac ggg caa ttg1152
Leu Leu Ala Thr Cys Ser Val Phe Val Glu Glu Asn Asp Gly Gln Leu370 375 380caa aaa ttc ctc aac cgc cat gcc gat gcc gaa ccg atc gaa tcg cgg1200Gln Lys Phe Leu Asn Arg His Ala Asp Ala Glu Pro Ile Glu Ser Arg385 390 395 400gtg ctt tta ccg aac aaa cac caa gat ggc ttt tat tac gcg ctt att1248Val Leu Leu Pro Asn Lys His Gln Asp Gly Phe Tyr Tyr Ala Leu Ile405 410 415caa aag cat1257Gln Lys His<210>168<211>419<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>168Met Ser Met Ala Leu Ala Gln Lys Leu Ala Ala Asp Ser Ile Ala Ala1 5 10 15Val Ala Glu Gly Arg Asn Leu Gln Asp Val Leu Ala Gln Ile Arg Thr20 25 30Ala His Pro Asp Leu Thr Ala Gln Glu Asn Gly Ala Leu Gln Asp Ile35 40 45Ala Tyr Gly Cys Gln Arg Tyr Leu Gly Ser Leu Lys His Met Leu Ala50 55 60Gln Met Leu Lys Lys Pro Ile Gly Asn Pro Gln Leu Glu Ser Leu Leu65 70 75 80Leu Ala Ala Leu Tyr Gln Leu His Tyr Thr Arg Asn Ala Pro His Ala85 90 95Val Val Asn Glu Ala Val Glu Ser Ile Ala Lys Ile Gly Arg Gly Gln100 105 110Tyr Arg Ser Phe Ala Asn Ala Ile Leu Arg Arg Phe Leu Arg Glu Arg115 120 125Asp Lys Leu Ala Ala Ser Cys Lys Lys Asp Asp Val Ala Lys His Asn130 135 140
Leu Pro Leu Trp Trp Val Ala Tyr Leu Lys Asn His Tyr Pro Lys His145 150 155 160Trp His Asn Ile Ala Ala Ala Leu Gln Ser His Pro Pro Met Thr Leu165 170 175Arg Val Asn Arg Arg His Gly Asn Ala Glu Ser Tyr Leu Glu Lys Leu180 185 190Ala Ala Glu Gly Ile Ala Ala Lys Ala Leu Asp Glu Tyr Ala Val Thr195 200 205Leu Glu Glu Ala Val Pro Val Asn Arg Leu Pro Gly Phe Ser Asp Gly210 215 220Ile Val Ser Val Gln Asp Phe Gly Ala Gln Gln Ala Ala Tyr Leu Leu225 230 235 240Asn Pro Lys Asp Gly Glu Arg Ile Leu Asp Ala Cys Ala Ala Pro Gly245 250 255Gly Lys Thr Gly His Ile Leu Glu Leu Ala Asp Cys Arg Val Thr Ala260 265 270Leu Asp Ile Asp Ala Gly Arg Leu Lys Arg Val Glu Asp Asn Ile Ala275 280 285Arg Leu Gly Phe Gln Thr Ala Ser Ala Ala Cys Ala Asp Ala Arg Asp290 295 300Leu Ala Ala Trp Tyr Asp Gly Lys Pro Phe Asp Thr Ile Leu Ala Asp305 310 315 320Val Pro Cys Thr Ala Ser Gly Val Ala Arg Arg Asn Pro Asp Val Lys325 330 335Trp Leu Arg Arg Pro Thr Asp Ala Leu Lys Thr Ala Arg Gln Gln Glu340 345 350Ala Leu Leu Asp Ala Leu Trp Gln Thr Leu Lys Gln Gly Gly Arg Met355 360 365Leu Leu Ala Thr Cys Ser Val Phe Val Glu Glu Asn Asp Gly Gln Leu370 375 380Gln Lys Phe Leu Asn Arg His Ala Asp Ala Glu Pro Ile Glu Ser Arg385 390 395 400
Va1 Leu Leu Pro Asn Lys His Gln Asp Gly Phe Tyr Tyr Ala Leu Ile405 410 4l5Gln Lys His<210>169<211>804<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(804)<400>169atg aat atg aaa aaa tgg att gcc gcc gcc ctt gcc tgt tcc gcg ctc48Met Asn Met Lys Lys Trp Ile Ala Ala Ala Leu Ala Cys Ser Ala Leu1 5 10 15gcg ctg tct gcc tgc ggc ggt cag ggt aaa gat gcc gcc gcg ccc gcc96Ala Leu Ser Ala Cys Gly Gly Gln Gly Lys Asp Ala Ala Ala Pro Ala20 25 30gca aat ccc gac aaa gtg tac cgc gtg gct tcc aac gcc gag ttt gcc144Ala Asn Pro Asp Lys Val Tyr Arg Val Ala Ser Asn Ala Glu Phe Ala35 40 45ccc ttt gaa tct tta gac tcg aaa ggc aat gtc gaa ggt ttc gat gtg192Pro Phe Glu Ser Leu Asp Ser Lys Gly Asn Val Glu Gly Phe Asp Val50 55 60gat ttg atg aac gcg atg gcg aag gcg ggc aat ttt aaa atc gaa ttc240Asp Leu Met Asn Ala Met Ala Lys Ala Gly Asn Phe Lys Ile Glu Phe65 70 75 80aaa cac cag ccg tgg gac agc ctt ttc ccc gcc ttg aac aac ggc gat288Lys His Gln Pro Trp Asp Ser Leu Phe Pro Ala Leu Asn Asn Gly Asp85 90 95gcg gac gtt gtg atg tcg ggc gta acc att acc gac gac cgc aaa cag336Ala Asp Val Val Met Ser Gly Val Thr Ile Thr Asp Asp Arg Lys Gln100 105 110tct atg gac ttc agc gac ccg tat ttt gaa atc acc caa gtc gtc ctc384Ser Met Asp Phe Ser Asp Pro Tyr Phe Glu Ile Thr Gln Val Val Leu
115 120 125gtt ccg aaa ggc aaa aaa ata tct tct tcc gaa gat ttg aaa aac atg432Val Pro Lys Gly Lys Lys Ile Ser Ser Ser Glu Asp Leu Lys Asn Met130 135 140aac aaa gtc ggc gtg gta acc ggc tac acg ggc gat ttc tcc gta tcc480Asn Lys Val Gly Val Val Thr Gly Tyr Thr Gly Asp Phe Ser Val Ser145 150 155 160aaa ctc ttg ggc aac gac aac ccg aaa atc gcg cgc ttt gaa aac gtt528Lys Leu Leu Gly Asn Asp Asn Pro Lys Ile Ala Arg Phe Glu Asn Val165 170 175ccc ctg att atc aaa gaa ctg gaa aac ggc ggc ttg gat tcc gtg gtc576Pro Leu Ile Ile Lys Glu Leu Glu Asn Gly Gly Leu Asp Ser Val Val180 185 190agc gac agc gca gtc atc gcc aat tat gtg aaa aac aat ccg acc aaa624Ser Asp Ser Ala Val Ile Ala Asn Tyr Val Lys Asn Asn Pro Thr Lys195 200 205ggg atg gac ttc gtt acc ctg ccc gac ttc acc acc gaa cac tac ggc672Gly Met Asp Phe Val Thr Leu Pro Asp Phe Thr Thr Glu His Tyr Gly210 215 220atc gcg gta cgc aaa ggc gac gaa gca acc gtc aaa atg ctg aac gat720Ile Ala Val Arg Lys Gly Asp Glu Ala Thr Val Lys Met Leu Asn Asp225 230 235 240gcg ttg aaa aaa gta cgc gaa agc ggc gaa tac gac aaa atc tac gcc768Ala Leu Lys Lys Val Arg Glu Ser Gly Glu Tyr Asp Lys Ile Tyr Ala245 250 255aaa tat ttt gca aaa gaa gac gga cag gcc gca aaa804Lys Tyr Phe Ala Lys Glu Asp Gly Gln Ala Ala Lys260 265<210>170<211>268<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>170Met Asn Met Lys Lys Trp Ile Ala Ala Ala Leu Ala Cys Ser Ala Leu1 5 10 15
Ala Leu Ser Ala Cys Gly Gly Gln Gly Lys Asp Ala Ala Ala Pro Ala20 25 30Ala Asn Pro Asp Lys Val Tyr Arg Val Ala Ser Asn Ala Glu Phe Ala35 40 45Pro Phe Glu Ser Leu Asp Ser Lys Gly Asn Val Glu Gly Phe Asp Val50 55 60Asp Leu Met Asn Ala Met Ala Lys Ala Gly Asn Phe Lys Ile Glu Phe65 70 75 80Lys His Gln Pro Trp Asp Ser Leu Phe Pro Ala Leu Asn Asn Gly Asp85 90 95Ala Asp Val Val Met Ser Gly Val Thr Ile Thr Asp Asp Arg Lys Gln100 105 110Ser Met Asp Phe Ser Asp Pro Tyr Phe Glu Ile Thr Gln Val Val Leu115 120 125Val Pro Lys Gly Lys Lys Ile Ser Ser Ser Glu Asp Leu Lys Asn Met130 135 140Asn Lys Val Gly Val Val Thr Gly Tyr Thr Gly Asp Phe Ser Val Ser145 150 155 160Lys Leu Leu Gly Asn Asp Asn Pro Lys Ile Ala Arg Phe Glu Asn Val165 170 175Pro Leu Ile Ile Lys Glu Leu Glu Asn Gly Gly Leu Asp Ser Val Val180 185 190Ser Asp Ser Ala Val Ile Ala Asn Tyr Val Lys Asn Asn Pro Thr Lys195 200 205Gly Met Asp Phe Val Thr Leu Pro Asp Phe Thr Thr Glu His Tyr Gly210 215 220Ile Ala Val Arg Lys Gly Asp Glu Ala Thr Val Lys Met Leu Asn Asp225 230 235 240Ala Leu Lys Lys Val Arg Glu Ser Gly Glu Tyr Asp Lys Ile Tyr Ala245 250 255Lys Tyr Phe Ala Lys Glu Asp Gly Gln Ala Ala Lys260 265
<210>171<211>864<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(864)<400>171atg aaa gca aaa atc ctg act tcc gtt gca ctg ctt gcc tgt tcc ggc48Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly1 5 10 15agc ctg ttt gcc caa acg ctg gca acc gtc aac ggt cag aaa atc gac96Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp20 25 30agt tcc gtc att gat gcg cag gtt gcc gca ttc cgt gcg gaa aac agc144Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser35 40 45cgt gcc gaa gac acg ccg caa ctg cgc caa tcc ctg ctg gaa aac gaa192Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu50 55 60gtg gtc aac acc gtg gtc gca cag gaa gtg aaa cgc ctg aaa ctc gac240Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp65 70 75 80cgg tcg gca gag ttt aaa aat gcg ctt gcc aaa ttg cgt gcc gaa gcg288Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala85 90 95aaa aag tcg ggc gac gac aag aaa ccg tcc ttc aaa acc gtt tgg cag336Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln100 105 110gcg gta aaa tat ggc ttg aac ggc gag gca tac gcg ctg cat atc gcc384Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala115 120 125aaa acc caa ccg gtt tcc gag cag gaa gta aaa gcc gca tat gac aat432Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn130 135 140
atc agc ggt ttt tac aaa ggt acg cag gaa gtc cag ttg ggc gaa atc480Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile145 150 155 160ctg acc gac aag gaa gaa aat gca aaa aaa gcg gtt gcc gac ttg aag528Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys165 170 175gcg aaa aaa ggt ttc gat gcc gtc ttg aaa caa tat tcc ctc aac gac576Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp180 185 190cgt acc aaa cag acc ggt gcg ccg gtc gga tat gtg ccg ctg aaa gat624Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp195 200 205ttg gaa cag ggt gtt ccg ccg ctt tat cag gca att aag gac ttg aaa672Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys210 215 220aaa ggc gaa ttt acg gca acg ccg ctg aaa aac ggc gat ttc tac ggc720Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly225 230 235 240gtt tat tat gtc aac gac agc cgc gag gta aaa gtg cct tct ttt gat768Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp245 250 255gaa atg aaa gga cag att gcg ggc aac ctt cag gcg gaa cgg att gac816Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp260 265 270cgt gcc gtc ggt gca ctg ttg ggc aag gca aac atc aaa cct gca aaa864Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys275 280 285<210>172<211>288<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>172Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly1 5 10 15Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp20 25 30
Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser35 40 45Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu50 55 60Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp65 70 75 80Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala85 90 95Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln100 105 110Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala115 120 125Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn130 135 140Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile145 150 155 160Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys165 170 175Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp180 185 190Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp195 200 205Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys210 215 220Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly225 230 235 240Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp245 250 255Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp260 265 270Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys275 280 285
<210>173<211>1794<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1794)<400>173ttg ccc cga att gcc atg ccc tat ttc gcc ctg ttt gac gat gcc gta48Leu Pro Arg Ile Ala Met Pro Tyr Phe Ala Leu Phe Asp Asp Ala Val1 5 10 15agc ggt cgc gca aaa cgc tat caa aat cat gtg gaa agc cgt ttt ttc96Ser Gly Arg Ala Lys Arg Tyr Gln Asn His Val Glu Ser Arg Phe Phe20 25 30cgt ccc gaa gaa ctc gat gct ttg gac ggc gcg ctg caa tcg ggc tgg144Arg Pro Glu Glu Leu Asp Ala Leu Asp Gly Ala Leu Gln Ser Gly Trp35 40 45caa aaa ggg ctg cat gcc gtg ttg ttt gca gac tac gga ttc ggt ttg192Gln Lys Gly Leu His Ala Val Leu Phe Ala Asp Tyr Gly Phe Gly Leu50 55 60ccg ctg acg ggg gtc gag tcc gaa cgc ggc ggc aac ctt gcc ctg cac240Pro Leu Thr Gly Val Glu Ser Glu Arg Gly Gly Asn Leu Ala Leu His65 70 75 80tgg ttt gcc gac tgc gcc gac acc gat gcc gca agc tgg ctt gcc cga288Trp Phe Ala Asp Cys Ala Asp Thr Asp Ala Ala Ser Trp Leu Ala Arg85 90 95cac tca gac ggc ctc ccc gcc ggc att tcc acg ccg caa tcc tcc gta336His Ser Asp Gly Leu Pro Ala Gly Ile Ser Thr Pro Gln Ser Ser Val100 105 110tcc gaa gcc gat tac ctc gac cat atc cgc caa atc cac gaa gcc atc384Ser Glu Ala Asp Tyr Leu Asp His Ile Arg Gln Ile His Glu Ala Ile115 120 125cga cgc ggc gac acc tat caa atc aac tac act acc cgc ctg cac ctg432Arg Arg Gly Asp Thr Tyr Gln Ile Asn Tyr Thr Thr Arg Leu His Leu130 135 140
caa gcc tac ggc aat ccc gtc aaa ctt tac caa cgc ctg cgc cag ccc480Gln Ala Tyr Gly Asn Pro Val Lys Leu Tyr Gln Arg Leu Arg Gln Pro145 150 155 160gtc ccc tat gcc gtt ttg tcc cac ctg ccc gat gca caa ggg caa tcc528Val Pro Tyr Ala Val Leu Ser His Leu Pro Asp Ala Gln Gly Gln Ser165 170 175gcg tgg acg ctg tgt ttc tcg ccc gaa ctc ttc ctc aaa atc ggt tcg576Ala Trp Thr Leu Cys Phe Ser Pro Glu Leu Phe Leu Lys Ile Gly Ser180 185 190gac ggc acc atc agc acc gaa ccg atg aaa ggc acc gcg ccg att ttg624Asp Gly Thr Ile Ser Thr Glu Pro Met Lys Gly Thr Ala Pro Ile Leu195 200 205ggc gac gga caa gac gaa cgc cgc gcc gcc gag ttg caa gca gac ccg672Gly Asp Gly Gln Asp Glu Arg Arg Ala Ala Glu Leu Gln Ala Asp Pro210 215 220aaa aac cgc gcc gaa aac gtg atg att gtc gat ttg ctg cgt aac gac720Lys Asn Arg Ala Glu Asn Val Met Ile Val Asp Leu Leu Arg Asn Asp225 230 235 240ctc ggc aaa atc gcc caa acc ggc aca gta tgc gta ccc gaa ccg ttt768Leu Gly Lys Ile Ala Gln Thr Gly Thr Val Cys Val Pro Glu Pro Phe245 250 255aaa gta tcg cgt ttc ggc agc gtt tgg cag atg acc agc acc atc caa816Lys Val Ser Arg Phe Gly Ser Val Trp Gln Met Thr Ser Thr Ile Gln260 265 270gcc caa gcc ttg ccg cac acc tcg ttc gcc gac atc ctc cgc gcc gcc864Ala Gln Ala Leu Pro His Thr Ser Phe Ala Asp Ile Leu Arg Ala Ala275 280 285ttc ccc tgc ggc agc atc acc ggc gcg ccc aaa aaa atg agt atg cag912Phe Pro Cys Gly Ser Ile Thr Gly Ala Pro Lys Lys Met Ser Met Gln290 295 300att atc gaa tcg ctc gaa gcc gaa gcg cgc gga ctt tat acg ggc agc960Ile Ile Glu Ser Leu Glu Ala Glu Ala Arg Gly Leu Tyr Thr Gly Ser305 310 315 320atc ggc tat ttg aac ccg tgt tcc ggc ggc ttg ggg ttt gaa ggc acg1008Ile Gly Tyr Leu Asn Pro Cys Ser Gly Gly Leu Gly Phe Glu Gly Thr325 330 335
ttc aac gtc gtt atc cgc acc ttg tcg ctc acg ccg ctt tca gac ggc1056Phe Asn Val Val Ile Arg Thr Leu Ser Leu Thr Pro Leu Ser Asp Gly340 345 350att tat caa ggc gtg tac ggt gtc ggt tcc ggc atc gtc atc gac agc1104Ile Tyr Gln Gly Val Tyr Gly Val Gly Ser Gly Ile Val Ile Asp Ser355 360 365gac cct gcc gcc gaa tat cgg gaa tgc ggc tgg aaa gcc cgt ttc ctc1152Asp Pro Ala Ala Glu Tyr Arg Glu Cys Gly Trp Lys Ala Arg Phe Leu370 375 380aac gaa ttg cgc ccc gac ttc ggc att ttt gaa acc ctg cgc gtg gaa1200Asn Glu Leu Arg Pro Asp Phe Gly Ile Phe Glu Thr Leu Arg Val Glu385 390 395 400aac gga cgc tgc gcc ctg ctc gac cgc cac cta tgc cgt ctg aaa acc1248Asn Gly Arg Cys Ala Leu Leu Asp Arg His Leu Cys Arg Leu Lys Thr405 410 415tcc gcc caa gcc ctc aac ctg ccc ctg ccc gac ggt tgc gaa aat caa1296Ser Ala Gln Ala Leu Asn Leu Pro Leu Pro Asp Gly Cys Glu Asn Gln420 425 430atc aaa caa tac atc gca cgc ttg ccc gac ggc gcg ttc cgc atc aaa1344Ile Lys Gln Tyr Ile Ala Arg Leu Pro Asp Gly Ala Phe Arg Ile Lys435 440 445gcc ctg ctc gct tca gac ggc atc agc ctg tcc cgc gcc gtt tta aac1392Ala Leu Leu Ala Ser Asp Gly Ile Ser Leu Ser Arg Ala Val Leu Asn450 455 460cgt ctg acc gac aaa caa cgc gtc atc att tcg ccg acc atc ctg ccc1440Arg Leu Thr Asp Lys Gln Arg Val Ile Ile Ser Pro Thr Ile Leu Pro465 470 475 480gca caa aac tac ctg cgc cgc ttc aaa acc acc tgc cgc acc gtc ttc1488Ala Gln Asn Tyr Leu Arg Arg Phe Lys Thr Thr Cys Arg Thr Val Phe485 490 495gac caa gcg tgg caa acc gcc gaa aca caa ggc gcg ttc gac agc ctg1536Asp Gln Ala Trp Gln Thr Ala Glu Thr Gln Gly Ala Phe Asp Ser Leu500 505 510ttt ttc aat tca gac ggc atc ctg ctc gaa ggc ggc aga agc aac gtg1584Phe Phe Asn Ser Asp Gly Ile Leu Leu Glu Gly Gly Arg Ser Asn Val515 520 525
ttc gtc aaa cat cgc gga caa tgg ctc acg ccc tct tta gat tta gac1632Phe Val Lys His Arg Gly Gln Trp Leu Thr Pro Ser Leu Asp Leu Asp530 535 540att tta aac ggc ata atg cgc caa gcc gtg ttg gac gaa ccg caa aaa1680Ile Leu Asn Gly Ile Met Arg Gln Ala Val Leu Asp Glu Pro Gln Lys545 550 555 560tat ttg caa aca aat caa gta atc gaa aca cac atc aca caa aaa aca1728Tyr Leu Gln Thr Asn Gln Val Ile Glu Thr His Ile Thr Gln Lys Thr565 570 575ctg caa gaa gcc gaa gaa atc cgc ctc tcc aac gcc ttg cgc ggc gta1776Leu Gln Glu Ala Glu Glu Ile Arg Leu Ser Asn Ala Leu Arg Gly Val580 585 590ttt gcc gcc gcc ctt gcc1794Phe Ala Ala Ala Leu Ala595<210>174<211>598<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>174Leu Pro Arg Ile Ala Met Pro Tyr Phe Ala Leu Phe Asp Asp Ala Val1 5 10 15Ser Gly Arg Ala Lys Arg Tyr Gln Asn His Val Glu Ser Arg Phe Phe20 25 30Arg Pro Glu Glu Leu Asp Ala Leu Asp Gly Ala Leu Gln Ser Gly Trp35 40 45Gln Lys Gly Leu His Ala Val Leu Phe Ala Asp Tyr Gly Phe Gly Leu50 55 60Pro Leu Thr Gly Val Glu Ser Glu Arg Gly Gly Asn Leu Ala Leu His65 70 75 80Trp Phe Ala Asp Cys Ala Asp Thr Asp Ala Ala Ser Trp Leu Ala Arg85 90 95His Ser Asp Gly Leu Pro Ala Gly Ile Ser Thr Pro Gln Ser Ser Val100 105 110
Ser Glu Ala Asp Tyr Leu Asp His Ile Arg Gln Ile His Glu Ala Ile115 120 125Arg Arg Gly Asp Thr Tyr Gln Ile Asn Tyr Thr Thr Arg Leu His Leu130 135 140Gln Ala Tyr Gly Asn Pro Val Lys Leu Tyr Gln Arg Leu Arg Gln Pro145 150 155 160Val Pro Tyr Ala Val Leu Ser His Leu Pro Asp Ala Gln Gly Gln Ser165 170 175Ala Trp Thr Leu Cys Phe Ser Pro Glu Leu Phe Leu Lys Ile Gly Ser180 185 190Asp Gly Thr Ile Ser Thr Glu Pro Met Lys Gly Thr Ala Pro Ile Leu195 200 205Gly Asp Gly Gln Asp Glu Arg Arg Ala Ala Glu Leu Gln Ala Asp Pro210 215 220Lys Asn Arg Ala Glu Asn Val Met Ile Val Asp Leu Leu Arg Asn Asp225 230 235 240Leu Gly Lys Ile Ala Gln Thr Gly Thr Val Cys Val Pro Glu Pro Phe245 250 255Lys Val Ser Arg Phe Gly Ser Val Trp Gln Met Thr Ser Thr Ile Gln260 265 270Ala Gln Ala Leu Pro His Thr Ser Phe Ala Asp Ile Leu Arg Ala Ala275 280 285Phe Pro Cys Gly Ser Ile Thr Gly Ala Pro Lys Lys Met Ser Met Gln290 295 300Ile Ile Glu Ser Leu Glu Ala Glu Ala Arg Gly Leu Tyr Thr Gly Ser305 310 315 320Ile Gly Tyr Leu Asn Pro Cys Ser Gly Gly Leu Gly Phe Glu Gly Thr325 330 335Phe Asn Val Val Ile Arg Thr Leu Ser Leu Thr Pro Leu Ser Asp Gly340 345 350Ile Tyr Gln Gly Val Tyr Gly Val Gly Ser Gly Ile Val Ile Asp Ser355 360 365
Asp Pro Ala Ala Glu Tyr Arg Glu Cys Gly Trp Lys Ala Arg Phe Leu370 375 380Asn Glu Leu Arg Pro Asp Phe Gly Ile Phe Glu Thr Leu Arg Val Glu385 390 395 400Asn Gly Arg Cys Ala Leu Leu Asp Arg His Leu Cys Arg Leu Lys Thr405 410 415Ser Ala Gln Ala Leu Asn Leu Pro Leu Pro Asp Gly Cys Glu Asn Gln420 425 430Ile Lys Gln Tyr Ile Ala Arg Leu Pro Asp Gly Ala Phe Arg Ile Lys435 440 445Ala Leu Leu Ala Ser Asp Gly Ile Ser Leu Ser Arg Ala Val Leu Asn450 455 460Arg Leu Thr Asp Lys Gln Arg Val Ile Ile Ser Pro Thr Ile Leu Pro465 470 475 480Ala Gln Asn Tyr Leu Arg Arg Phe Lys Thr Thr Cys Arg Thr Val Phe485 490 495Asp Gln Ala Trp Gln Thr Ala Glu Thr Gln Gly Ala Phe Asp Ser Leu500 505 510Phe Phe Asn Ser Asp Gly Ile Leu Leu Glu Gly Gly Arg Ser Asn Val515 520 525Phe Val Lys His Arg Gly Gln Trp Leu Thr Pro Ser Leu Asp Leu Asp530 535 540Ile Leu Asn Gly Ile Met Arg Gln Ala Val Leu Asp Glu Pro Gln Lys545 550 555 560Tyr Leu Gln Thr Asn Gln Val Ile Glu Thr His Ile Thr Gln Lys Thr565 570 575Leu Gln Glu Ala Glu Glu Ile Arg Leu Ser Asn Ala Leu Arg Gly Val580 585 590Phe Ala Ala Ala Leu Ala595
<210>175<211>279<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(279)<400>175ttg caa aac ttt cgg aaa ccc aat atg cag acc gtt acc atg tac aca48Leu Gln Asn Phe Arg Lys Pro Asn Met Gln Thr Val Thr Met Tyr Thr1 5 10 15ggt ccg ttt tgc ccc tac tgc acg atg gcg aaa agg ctg ctg cac gcg96Gly Pro Phe Cys Pro Tyr Cys Thr Met Ala Lys Arg Leu Leu His Ala20 25 30gca ggt gtc gga cat atc gac gaa atc cgt gtc gat gca agt ccc gaa144Ala Gly Val Gly His Ile Asp Glu Ile Arg Val Asp Ala Ser Pro Glu35 40 45gcc ttt gcc gaa atg cag cag ctt tcc gga cag cgc agc gtg ccg cag192Ala Phe Ala Glu Met Gln Gln Leu Ser Gly Gln Arg Ser Val Pro Gln50 55 60att ttc atc ggc gaa acg cac gtc ggc gga ttt acc gac ctc tac cgc240Ile Phe Ile Gly Glu Thr His Val Gly Gly Phe Thr Asp Leu Tyr Arg65 70 75 80ctc cag cag gaa ggc ggg ctg gac gga ctg ctg aac cct279Leu Gln Gln Glu Gly Gly Leu Asp Gly Leu Leu Asn Pro85 90<210>176<211>93<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>176Leu Gln Asn Phe Arg Lys Pro Asn Met Gln Thr Val Thr Met Tyr Thr1 5 10 15Gly Pro Phe Cys Pro Tyr Cys Thr Met Ala Lys Arg Leu Leu His Ala20 25 30Ala Gly Val Gly His Ile Asp Glu Ile Arg Val Asp Ala Ser Pro Glu
35 40 45Ala Phe Ala Glu Met Gln Gln Leu Ser Gly Gln Arg Ser Val Pro Gln50 55 60Ile Phe Ile Gly Glu Thr His Val Gly Gly Phe Thr Asp Leu Tyr Arg65 70 75 80Leu Gln Gln Glu Gly Gly Leu Asp Gly Leu Leu Asn Pro85 90<210>177<211>2274<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(2274)<400>177atg aca aca tta cat ttc tca ggc ttc ccg cgt gtc ggt gcc ttc cgc48Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg1 5 10 15gaa ttg aaa ttc gca caa gaa aaa tac tgg cgc aaa gaa atc agc gag96Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu20 25 30caa gaa ttg ctg gct gtt gct aaa gac ttg cgc gag aaa aac tgg aaa144Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys35 40 45cac cag gcc gct gcc aac gcc gat tac gtt gcc gta ggc gat ttc act192His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr50 55 60ttc tac gac cac atc ctc gac ctg caa gtc gcc acc ggc gcg att ccc240Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro65 70 75 80gcc cgc ttc ggc ttc gac agc caa aac cta tct ttg gaa caa ttc ttc288Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe85 90 95caa ctg gcg cgc ggt aac aaa gac caa ttc gct atc gaa atg acc aaa336
Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys100 105 110tgg ttc gac acc aac tac cac tac ttg gtg cct gaa ttc cac gcc gat384Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp115 120 125acc gaa ttt aaa gcc aat gcc aaa cac tac gtt caa cag ctg caa gaa432Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu130 135 140gcc caa gct ttg ggc ctg aaa gcc aaa ccg acc gtt gtg ggt ccg ttg480Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu145 150 155 160act ttc ctg tgg gtc ggt aaa gaa aaa ggc gcc gtt gaa ttc gac cgt528Thr Phe Leu Trp Val Gly Ays Glu Lys Gly Ala Val Glu Phe Asp Arg165 170 175ctg agc ctg ttg cct aaa ctg ttg cct gtt tac gtt gaa atc ctg act576Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr180 185 190gct ttg gtt gaa gcc ggt gcc gag tgg att caa atc gac gag cct gct624Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala195 200 205ttg act gtt gac ctg cct aaa gaa tgg gta gaa gca tac aaa gac gtt672Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val210 215 220tac gcc act ttg agc aaa gta agt gcc aaa atc ctg ctg agc act tac720Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr225 230 235 240ttc ggt tct gtt gcc gaa cac gcc gca ttg ttg aaa tcc ctg cct gtt768Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val245 250 255gac ggc ctg cac atc gac ttg gta cgc gct cct gaa caa ctg gat gcg816Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala260 265 270ttc gcc gac tac gac aaa gtt ctg tct gcc ggc gtc att gac ggc cgc864Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg275 280 285aat att tgg cgc gcc aac ctg aac aaa gtt ttg gaa act gtt gag ctt912
Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu290 295 300ctg caa gcc aaa ctg ggc gac cgt ttg tgg att tcc agc tct tgc tcg960Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser305 310 3l5 320ctg ctg cac act ccg ttt gac ttg tca gtt gaa gaa aaa ctg aaa gcc1008Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala325 330 335aac aaa ccc gac ctg tac tct tgg ttg gca ttc acc ctg caa aaa acc1056Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr340 345 350caa gaa ttg cgc gtc ctg aaa gcc gca ttg aac gaa ggc cgt gat tct1104Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser355 360 365gtt gcc gaa gaa ctg gct gcc agc caa gct gct gcc gac tcc cgt gcc1152Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala370 375 380aac agc agc gaa atc cac cgt gca gac gtt gcc aaa cgc ctg gcc gat1200Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp385 390 395 400ttg cct gcc aac gca gac caa cgc aaa tcc cca ttt gcc gac cgt atc1248Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile405 410 415aaa gcg caa caa gca tgg ttg aac ctg cct ctg ctg ccg acg acc aac1296Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn420 425 430atc ggt tct ttc ccg caa act acc gaa atc cgc caa gca cgc gca gcc1344Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala435 440 445ttc aaa aaa ggc gaa ctg tct gcc gcc gat tac gaa gcc gcg atg aaa1392Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys450 455 460aaa gaa atc gcc ttg gtg gtt gaa gag caa gaa aaa ctg gac ttg gac1440Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp465 470 475 480gta ctg gta cac ggc gaa gcc gag cgt aac gac atg gtt gaa tac ttc1488
Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe485 490 495ggc gaa ttg ttg agc ggt ttt gca ttc acc caa tat ggc tgg gta caa1536Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln500 505 510agc tac ggt tct cgc tgc gtt aaa cca ccg att atc ttc ggt gac gta1584Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val515 520 525agc cgt cct gaa gcc atg acc gta gct tgg tct act tac gca caa agc1632Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser530 535 540ctg acc aaa cgc ccg atg aaa ggt atg ttg acc ggc cct gta acc att1680Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile545 550 555 560ctg caa tgg tct ttc gtc cgc aac gat att cct cgc tct acc gtg tgt1728Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys565 570 575aaa caa atc gca ctg gct ctg aac gac gaa gta ttg gat ctg gaa aaa1776Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys580 585 590gca ggc atc aaa gtc atc caa atc gac gaa cct gcc atc cgc gaa ggc1824Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly595 600 605ctg cct ttg aaa cgt gcc gat tgg gat gcc tac ctg aac tgg gcc ggc1872Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly610 615 620gaa tct ttc cgc ctg tcc tct acc ggt tgc gaa gac agc act caa atc1920Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile625 630 635 640cac acc cat atg tgc tac tct gag ttc aac gac atc ctg cct gcg att1968His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile645 650 655gct gca atg gat gcg gac gtg atc acc atc gag act tca cgt tcc gac2016Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp660 665 670atg gaa ctc ttg acc gcg ttc ggc gaa ttc aaa tac ccg aac gac atc2064
Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile675 680 685ggc ccg ggg gtt tac gac atc cac agc ccg cgc gta ccg aca gaa gcc2112Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala690 695 700gaa gtg gag cac ctg ttg cgc aaa gcc atc gag gtt gta ccg gtt gaa2160Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu705 710 715 720cgt ctg tgg gtt aac ccg gac tgc ggc ctg aaa aca cgc ggc tgg aaa2208Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys725 730 735gaa act ctg gaa caa ctc caa gtg atg atg aac gta acc cac aaa ttg2256Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu740 745 750cgt gcc gaa ttg gcg aaa2274Arg Ala Glu Leu Ala Lys755<210>178<211>758<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>178Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg1 5 10 15Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu20 25 30Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys35 40 45His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr50 55 60Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro65 70 75 80Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe85 90 95
Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys100 105 110Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp115 120 125Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu130 135 140Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu145 150 155 160Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg165 170 175Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr180 185 190Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala195 200 205Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val210 215 220Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr225 230 235 240Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val245 250 255Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala260 265 270Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg275 280 285Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu290 295 300Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser305 310 315 320Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala325 330 335Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr340 345 350
Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser355 360 365Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala370 375 380Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp385 390 395 400Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile405 410 415Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn420 425 430Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala435 440 445Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys450 455 460Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp465 470 475 480Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe485 490 495Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln500 505 510Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val515 520 525Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser530 535 540Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile545 550 555 560Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg ger Thr Val Cys565 570 575Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys580 585 590Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly595 600 605
Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly610 615 620Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile625 630 635 640His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile645 650 655Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp660 665 670Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile675 680 685Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala690 695 700Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu705 710 715 720Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys725 730 735Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu740 745 750Arg Ala Glu Leu Ala Lys755<210>179<211>867<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(867)<400>179atg aaa ccc ata cgg aaa gcc gtc ttc ccc gtc gca ggg atg gga aca48Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr1 5 10 15cgc ttc ctg ccc gcc acc aag gca agc ccg aaa gaa atg ctg ccc atc96Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile
20 25 30gtc gac aag ccg ctg atc caa tac gcc gta gaa gaa gcc gtg gaa gcc144Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Clu Ala35 40 45ggc tgc acg gaa atg gtg ttt gtt acc gga cgc aac aaa cgc agc atc192Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile50 55 60gaa gac cat ttc gac aag gca tac gaa ctc gaa acc gag ttg gaa atg240Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met65 70 75 80cgc cat aaa gac aaa ttg ttg gaa cac gtc cgc aac atc ctg ccg ccg288Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro85 90 95aac att acc tgc ctc tac atc cgt cag gcg gaa gca ctg ggc ttg gga336Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly100 105 110cac gcc gtc ttg tgc gcc cgc gcc gcc atc ggc gac gaa ccc ttt gcc384His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala115 120 125gtg att ttg gct gac gat tta atc gat gcc caa aaa ggc gcg ctc aaa432Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys130 135 140caa atg gtc gaa gtg tac gaa cgc agc ggc aac agc att ttg ggc gta480Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val145 150 155 160gaa act gtc gaa ccg tcg caa acc ggc tca tac ggc atc gtc gaa acc528Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr165 170 175gaa cag ctc aaa cag ttc caa cgc att acc ggc att gtc gaa aaa ccc576Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro180 185 190aag ccc gaa gac gcg ccc tcc aac ctt gcc gtc gtc gga cgc tac atc624Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile195 200 205ctt acc ccg cgc att ttc gac tta ctg acc gga ctg ccg cgc ggc gcg672Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala
210 215 220ggc aac gaa atc cag ctt aca gac ggc atc gcc aag ctg ctc gat cac720Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His225 230 235 240gaa ttt gtc cta gcg cac ccc ttt gaa ggc acg cgc tac gac tgc ggc768Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly245 250 255agc aaa ctg ggc tat ctg gaa gcc acc gtc gcc tac ggc ctg aaa cac816Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His260 265 270ccc gaa acc ggc gaa ccc ttc cgc cgc ctt ttg gaa aaa tac cgt acc864Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr275 280 285gaa867Glu<210>180<211>289<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>180Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr1 5 10 15Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile20 25 30Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Glu Ala35 40 45Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile50 55 60Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met65 70 75 80Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro85 90 95Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly100 105 110
His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala115 120 125Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys130 135 140Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val145 150 155 160Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr165 170 175Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro180 185 190Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile195 200 205Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala210 215 220Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His225 230 235 240Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly245 250 255Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His260 265 270Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr275 280 285Glu<210>181<211>603<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(603)
<400>181atg aca ata atg aat atc aat act tcc gaa aat aaa gat gct gtt gcc48Met Thr Ile Met Asn Ile Asn Thr Ser Glu Asn Lys Asp Ala Val Ala1 5 10 15gaa cac acc gga caa tgg ttg gaa aaa gcc gtc atc ggt ctg aac ctg96Glu His Thr Gly Gln Trp Leu Glu Lys Ala Val Ile Gly Leu Asn Leu20 25 30tgt ccc ttt gcc aaa gcc ccc cac gtt aaa aac ctt gtc cgc atc gca144Cys Pro Phe Ala Lys Ala Pro His Val Lys Asn Leu Val Arg Ile Ala35 40 45atc agc gaa gcc aaa cac ctt gac agt ttt ttg gaa gac ttg gac gaa192Ile Ser Glu Ala Lys His Leu Asp Ser Phe Leu Glu Asp Leu Asp Glu50 55 60gaa ctg cag cga ctg ggc aat aca ccc gcc acc gaa ctg gaa act acc240Glu Leu Gln Arg Leu Gly Asn Thr Pro Ala Thr Glu Leu Glu Thr Thr65 70 75 80ctg ctg gtt cac ccg acc cta ttc ccc gat ttc gac gta ttc aac gat288Leu Leu Val His Pro Thr Leu Phe Pro Asp Phe Asp Val Phe Asn Asp85 90 95atg ctc gac att gcc gat gcc gcc gtt gtc gaa aac ggc ttg gaa ggc336Met Leu Asp Ile Ala Asp Ala Ala Val Val Glu Asn Gly Leu Glu Gly100 105 110atc atc caa atc gcc ccg ttt cat ccc gat ttc caa ttt gaa ggc acg384Ile Ile Gln Ile Ala Pro Phe His Pro Asp Phe Gln Phe Glu Gly Thr115 120 125gat tca gac gac atc ggc aac tac acc aac cgt tct ccc tat ccg acg432Asp Ser Asp Asp Ile Gly Asn Tyr Thr Asn Arg Ser Pro Tyr Pro Thr130 135 140ctg cac ctc atc cgc gaa gac agc att gcc aaa gcc gca caa gcc ttt480Leu His Leu Ile Arg Glu Asp Ser Ile Ala Lys Ala Ala Gln Ala Phe145 150 155 160ccc gac gct tcg gca ata ttc gaa cgc aat atc gcc ctg ctg gaa aaa528Pro Asp Ala Ser Ala Ile Phe Glu Arg Asn Ile Ala Leu Leu Glu Lys165 170 175atg gga cat gag ggc tgg gca aaa ctc ggt atc aca tcc tgc cct tat576Met Gly His Glu Gly Trp Ala Lys Leu Gly Ile Thr Ser Cys Pro Tyr180 185 190
ccg cac aat aag aaa aat att tca aaa 603Pro His Asn Lys Lys Asn Ile Ser Lys195 200<210>182<211>201<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>182Met Thr Ile Met Asn Ile Asn Thr Ser Glu Asn Lys Asp Ala Val Ala1 5 10 15Glu His Thr Gly Gln Trp Leu Glu Lys Ala Val Ile Gly Leu Asn Leu20 25 30Cys Pro Phe Ala Lys Ala Pro His Val Lys Asn Leu Val Arg Ile Ala35 40 45Ile Ser Glu Ala Lys His Leu Asp Ser Phe Leu Glu Asp Leu Asp Glu50 55 60Glu Leu Gln Arg Leu Gly Asn Thr Pro Ala Thr Glu Leu Glu Thr Thr65 70 75 80Leu Leu Val His Pro Thr Leu Phe Pro Asp Phe Asp Val Phe Asn Asp85 90 95Met Leu Asp Ile Ala Asp Ala Ala Val Val Glu Asn Gly Leu Glu Gly100 105 110Ile Ile Gln Ile Ala Pro Phe His Pro Asp Phe Gln Phe Glu Gly Thr115 120 125Asp Ser Asp Asp Ile Gly Asn Tyr Thr Asn Arg Ser Pro Tyr Pro Thr130 135 140Leu His Leu Ile Arg Glu Asp Ser Ile Ala Lys Ala Ala Gln Ala Phe145 150 155 160Pro Asp Ala Ser Ala Ile Phe Glu Arg Asn Ile Ala Leu Leu Glu Lys165 170 175Met Gly His Glu Gly Trp Ala Lys Leu Gly Ile Thr Ser Cys Pro Tyr180 185 190
Pro His Asn Lys Lys Asn Ile Ser Lys195 200<210>183<211>1338<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1338)<400>183ttg cac acc ctt cta gct ttt atc ttc gcc atc ctg att ttg gtc agc48Leu His Thr Leu Leu Ala Phe Ile Phe Ala Ile Leu Ile Leu Val Ser1 5 10 15ctg cac gaa ttc gga cac tac atc gtc gcc aga ttg tgc ggc gtc aag96Leu His Glu Phe Gly His Tyr Ile Val Ala Arg Leu Cys Gly Val Lys20 25 30gtt gtg cgt ttt tcc gtc ggc ttc ggc aaa ccg ttt ttc acc cga aag144Val Val Arg Phe Ser Val Gly Phe Gly Lys Pro Phe Phe Thr Arg Lys35 40 45cgc ggc gac acc gaa tgg tgc ctc gcc ccg att ccg ttg ggc ggt tac192Arg Gly Asp Thr Glu Trp Cys Leu Ala Pro Ile Pro Leu Gly Gly Tyr50 55 60gtc aaa atg gtc gac acg cgc gaa ggc gaa gta tca gaa gcc gat tta240Val Lys Met Val Asp Thr Arg Glu Gly Glu Val Ser Glu Ala Asp Leu65 70 75 80ccc tac gct ttt gac aaa caa cac ccc gcc aag cgc atc gcc atc gtc288Pro Tyr Ala Phe Asp Lys Gln His Pro Ala Lys Arg Ile Ala Ile Val85 90 95gcc gcc ggc ccg ctg acc aac ctc gca ctg gcg gtt ttg ctg tac gga336Ala Ala Gly Pro Leu Thr Asn Leu Ala Leu Ala Val Leu Leu Tyr Gly100 105 110ctg agc ttt tcc ttc ggc gtt acc gaa ctg cgc ccc tat gtc ggc aca384Leu Ser Phe Ser Phe Gly Val Thr Glu Leu Arg Pro Tyr Val Gly Thr115 120 125gtc gaa ccc gac acc att gcc gcc cgc gcc ggc ttc caa agc ggc gac432
Val Glu Pro Asp Thr Ile Ala Ala Arg Ala Gly Phe Gln Ser Gly Asp130 135 140aaa ata caa tcc gtc aac ggc aca ccc gtt gca gat tgg ggc agc gcg480Lys Ile Gln Ser Val Asn Gly Thr Pro Val Ala Asp Trp Gly Ser Ala145 150 155 160caa acc gaa atc gtc ctc aac ctc gaa gcc ggc aaa gtc gcc gtc ggc528Gln Thr Glu Ile Val Leu Asn Leu Glu Ala Gly Lys Val Ala Val Gly165 170 175gtt cag acg gca tcg ggc gcg caa acc gtc cgc acc atc gat gcc gca576Val Gln Thr Ala Ser Gly Ala Gln Thr Val Arg Thr Ile Asp Ala Ala180 185 190ggc acg ccg gaa gcc ggt aaa atc gca aaa aac caa ggc tac atc gga624Gly Thr Pro Glu Ala Gly Lys Ile Ala Lys Asn Gln Gly Tyr Ile Gly195 200 205ctg atg ccc ttt aaa atc aca acc gtt gcc ggc ggc gtg gaa aaa ggc672Leu Met Pro Phe Lys Ile Thr Thr Val Ala Gly Gly Val Glu Lys Gly210 215 220agc ccc gcc gaa aaa gca ggc ctg aaa ccg ggc gac agg ctg act gcc720Ser Pro Ala Glu Lys Ala Gly Leu Lys Pro Gly Asp Arg Leu Thr Ala225 230 235 240gcc gac ggc aaa ccc atc gcc tca tgg caa gaa tgg gca aac ctg acc768Ala Asp Gly Lys Pro Ile Ala Ser Trp Gln Glu Trp Ala Asn Leu Thr245 250 255cgc caa agc ccc ggc aaa aaa atc acc ctg acc tac gaa cgc gcc gga816Arg Gln Ser Pro Gly Lys Lys Ile Thr Leu Thr Tyr Glu Arg Ala Gly260 265 270caa acc cat acc gcc gac atc cgc ccc gat act gtc gaa cag ccc gac864Gln Thr His Thr Ala Asp Ile Arg Pro Asp Thr Val Glu Gln Pro Asp275 280 285cac acc ctg atc ggg cgc gtc ggc ctc cgt ccg cag ccg gac agg gcg912His Thr Leu Ile Gly Arg Val Gly Leu Arg Pro Gln Pro Asp Arg Ala290 295 300tgg gac gcg caa atc cgc cgc agc tac cgt ccg tct gtt gtc cgc gca960Trp Asp Ala Gln Ile Arg Arg Ser Tyr Arg Pro Ser Val Val Arg Ala305 310 315 320ttc ggc atg ggc tgg gaa aaa acc gtt tcc cac tcg tgg aca acc ctc1008
Phe Gly Met Gly Trp Glu Lys Thr Val Ser His Ser Trp Thr Thr Leu325 330 335aaa ttt ttc ggc aaa cta atc agc ggc aac gcc tcc gtc agc cat att1056Lys Phe Phe Gly Lys Leu Ile Ser Gly Asn Ala Ser Val Ser His Ile340 345 350tcc ggt ccg ctg acc att gcc gat att gcc gga cag tcc gcc gaa ctc1104Ser Gly Pro Leu Thr Ile Ala Asp Ile Ala Gly Gln Ser Ala Glu Leu355 360 365ggc ttg caa agt tat ttg gaa ttt ttg gca ctg gtc agc atc agc ctc1152Gly Leu Gln Ser Tyr Leu Glu Phe Leu Ala Leu Val Ser Ile Ser Leu370 375 380ggc gtg ctg aac ctg ctg ccc gtc ccc gtt ttg gac ggc ggc cac ctc1200Gly Val Leu Asn Leu Leu Pro Val Pro Val Leu Asp Gly Gly His Leu385 390 395 400gtg ttt tat act gcc gaa tgg ata cgc ggc aaa cct ttg ggc gaa cgc1248Val Phe Tyr Thr Ala Glu Trp Ile Arg Gly Lys Pro Leu Gly Glu Arg405 410 415gtc caa aac atc ggt ttg cgc ttc ggg ctt gcc ctc atg atg ctg atg1296Val Gln Asn Ile Gly Leu Arg Phe Gly Leu Ala Leu Met Met Leu Met420 425 430atg gcg gtc gcc ttc ttc aac gac gtt acc cgg ctg ctc ggt1338Met Ala Val Ala Phe Phe Asn Asp Val Thr Arg Leu Leu Gly435 440 445<210>184<211>446<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>184Leu His Thr Leu Leu Ala Phe Ile Phe Ala Ile Leu Ile Leu Val Ser1 5 10 15Leu His Glu Phe Gly His Tyr Ile Val Ala Arg Leu Cys Gly Val Lys20 25 30Val Val Arg Phe Ser Val Gly Phe Gly Lys Pro Phe Phe Thr Arg Lys35 40 45Arg Gly Asp Thr Glu Trp Cys Leu Ala Pro Ile Pro Leu Gly Gly Tyr
50 55 60Val Lys Met Val Asp Thr Arg Glu Gly Glu Val Ser Glu Ala Asp Leu65 70 75 80Pro Tyr Ala Phe Asp Lys Gln His Pro Ala Lys Arg Ile Ala Ile Val85 90 95Ala Ala Gly Pro Leu Thr Asn Leu Ala Leu Ala Val Leu Leu Tyr Gly100 105 110Leu Ser Phe Ser Phe Gly Val Thr Glu Leu Arg Pro Tyr Val Gly Thr115 120 125Val Glu Pro Asp Thr Ile Ala Ala Arg Ala Gly Phe Gln Ser Gly Asp130 135 140Lys Ile Gln Ser Val Asn Gly Thr Pro Val Ala Asp Trp Gly Ser Ala145 150 155 160Gln Thr Glu Ile Val Leu Asn Leu Glu Ala Gly Lys Val Ala Val Gly165 170 175Val Gln Thr Ala Ser Gly Ala Gln Thr Val Arg Thr Ile Asp Ala Ala180 185 190Gly Thr Pro Glu Ala Gly Lys Ile Ala Lys Asn Gln Gly Tyr Ile Gly195 200 205Leu Met Pro Phe Lys Ile Thr Thr Val Ala Gly Gly Val Glu Lys Gly210 215 220Ser Pro Ala Glu Lys Ala Gly Leu Lys Pro Gly Asp Arg Leu Thr Ala225 230 235 240Ala Asp Gly Lys Pro Ile Ala Ser Trp Gln Glu Trp Ala Asn Leu Thr245 250 255Arg Gln Ser Pro Gly Lys Lys Ile Thr Leu Thr Tyr Glu Arg Ala Gly260 265 270Gln Thr His Thr Ala Asp Ile Arg Pro Asp Thr Val Glu Gln Pro Asp275 280 285His Thr Leu Ile Gly Arg Val Gly Leu Arg Pro Gln Pro Asp Arg Ala290 295 300Trp Asp Ala Gln Ile Arg Arg Ser Tyr Arg Pro Ser Val Val Arg Ala
305 310 315 320Phe Gly Met Gly Trp Glu Lys Thr Val Ser His Ser Trp Thr Thr Leu325 330 335Lys Phe Phe Gly Lys Leu Ile Ser Gly Asn Ala Ser Val Ser His Ile340 345 350Ser Gly Pro Leu Thr Ile Ala Asp Ile Ala Gly Gln Ser Ala Glu Leu355 360 365Gly Leu Gln Ser Tyr Leu Glu Phe Leu Ala Leu Val Ser Ile Ser Leu370 375 380Gly Val Leu Asn Leu Leu Pro Val Pro Val Leu Asp Gly Gly His Leu385 390 395 400Val Phe Tyr Thr Ala Glu Trp Ile Arg Gly Lys Pro Leu Gly Glu Arg405 410 415Val Gln Asn Ile Gly Leu Arg Phe Gly Leu Ala Leu Met Met Leu Met420 425 430Met Ala Val Ala Phe Phe Asn Asp Val Thr Arg Leu Leu Gly435 440 445<210>185<211>1476<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1476)<400>185atg aaa tac aaa gac ctg cgc gac ttc atc gcc atg ctc gag cag cag48Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln1 5 10 15ggc aaa ctc aaa cgc atc gcg cac ccc gtt tcc ccg cat ttg gaa atg96Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met20 25 30acc gaa atc gcc gac cgc gtg ctg cgc gcc gaa ggg ccg gcg ttg ttg144Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu
35 40 45ttt gaa cac cca gtt aag ccc gac ggt acg cgc tat gat tat ccc gtg192Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr pro Val50 55 60ttg gca aac ctg ttc ggc acg ccc gaa cgt gtg gcg atg ggc atg ggc240Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly65 70 75 80gcg gac agc gtg tcc aag ctg cgc gaa atc ggg cag acg ctg gcg tat288Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr85 90 95ttg aaa gaa ccc gaa ccg ccc aaa ggc att aaa gac gcg ttt tcc aaa336Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys100 105 110ctg ccg ctc ttg aaa gac att tgg agc atg gcg ccg aac gtg gtg aaa384Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys115 120 125aat gcg ccg tgt cag gaa atc gta tgg gaa ggc gaa gac gtt gat ttg432Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu130 135 140tat caa ctt ccg att cag cat tgc tgg ccg gaa gac gtt gcg ccg ctg480Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu145 150 155 160gta acg tgg ggc ttg acc gtc acg cgc ggg ccg cac aaa aaa cgc caa528Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln165 170 175aat ctc ggc att tac cgc caa caa tta atc ggc ata aac aag ctg att576Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile180 185 190atg cgc tgg ctg tcg cat cgc ggc ggc gcg ctg gat tat cag gaa ttc624Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe195 200 205cgc aaa ctc aat ccc gat acg ccg tat ccc gtc gcc gtc gtg ctc ggc672Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly210 215 220tgc gac cct gcc acc att ttg ggc gcg gta acg ccc gtt ccc gat acc720Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr
225 230 235 240ttg agc gaa tac cag ttt gcc gga ctg ctg cgc ggt tcg cgg acg gaa768Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu245 250 255ctg gtg aaa tgt atc ggc aac gat ttg caa gtg cct gcc cgc gca gaa816Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu260 265 270atc gtg ttg gaa ggc gtc atc cat cca aac gaa acc gcgttg gaa ggt864Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly275 280 285cca tac ggc gac cac acg ggc tat tac aac gag cag gac cat ttc ccc912Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro290 295 300gtg ttt acg gtc gaa cgc atc acc atg cgc gaa aac ccg att tac cac960Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His305 310 315 320tct acc tac aca ggc aaa ccg ccc gat gaa ccc gcc gtt ttg ggc gtg1008Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val325 330 335gcg ttg aac gaa gtg ttc gta ccg ctt ttg caa aag cag ttc ccc gaa1056Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu340 345 350atc acc gat ttt tac ctg ccg ccc gaa ggc tgc tcc tac cgc atg gcg1104Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala355 360 365gtg gtg agc atg aaa aaa cag tac gcc gga cac gcc aag cgc gtg atg1152Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met370 375 380atg ggc tgc tgg tcg ttc ctg cgc cag ttt atg tac acc aaa ttc atc1200Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile385 390 395 400att gtg gtg gat gac gat gtg gat gtg cgc gac tgg aaa gaa gtc atc1248Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile405 410 415tgg gcg gta acc acg cgc atg gac ccc gtg cgc gat acc gtt ttg atg1296Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met
420 425 430gaa aac acg ccc atc gac tac ctc gac ttc gcc agc ccc gtc agc gga1344Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly435 440 445ctt ggc ggc aaa atg ggt ttg gat gcg acc aac aag tgg ccg ggc gaa1392Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu450 455 460acc gac cgc gaa tgg gga cgg gtg att aaa aaa gac cct gcg gtt acg1440Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr465 470 475 480gct aag att gat gag att tgg gag gaa ttg ggg ttg1476Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu485 490<210>186<211>492<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>186Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln1 5 10 15Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met20 25 30Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu35 40 45Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val50 55 60Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly65 70 75 80Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr85 90 95Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys100 105 110Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys115 120 125
Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu130 135 140Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu145 150 155 160Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln165 170 175Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile180 185 190Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe195 200 205Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly210 215 220Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr225 230 235 240Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu245 250 255Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu260 265 270Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly275 280 285Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro290 295 300Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His305 310 315 320Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val325 330 335Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu340 345 350Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala355 360 365Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met370 375 380
Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile385 390 395 400Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile405 410 415Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met420 425 430Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly435 440 445Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu450 455 460Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr465 470 475 480Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu485 490<210>187<211>1191<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1191)<400>187atg ttc ttc aag cac atc gaa gcc gcc ccc gcc gat ccg att ctc ggt48Met Phe Phe Lys His Ile Glu Ala Ala Pro Ala Asp Pro Ile Leu Gly1 5 10 15ttg ggc gaa gca ttc aaa gcc gaa acc cgc ccc gaa aaa gtc aac ctc96Leu Gly Glu Ala Phe Lys Ala Glu Thr Arg Pro Glu Lys Val Asn Leu20 25 30ggc atc ggc gtg tac aaa gac gca tcc ggc gcg aca cct att gtc aaa144Gly Ile Gly Val Tyr Lys Asp Ala Ser Gly Ala Thr Pro Ile Val Lys35 40 45gcc gtc aaa gaa gcc gaa aaa cgc ctg ttg gaa agc gaa aca act aaal92Ala Val Lys Glu Ala Glu Lys Arg Leu Leu Glu Ser Glu Thr Thr Lys
50 55 60aac tac ctc acc atc gac ggc gtt gcc gac tac aac gag caa acc caa240Asn Tyr Leu Thr Ile Asp Gly Val Ala Asp Tyr Asn Glu Gln Thr Gln65 70 75 80att ctg ctg ttc ggc aaa gac cac gaa atc atc gcc agc cgt cgc gcc288Ile Leu Leu Phe Gly Lys Asp His Glu Ile Ile Ala Ser Arg Arg Ala85 90 95aaa aca gcg caa agc ctt ggc ggt aca ggc gca ttg cgt att gcg gcc336Lys Thr Ala Gln Ser Leu Gly Gly Thr Gly Ala Leu Arg Ile Ala Ala100 105 110gag ttt gcc aaa cgt cag ttg aac gcg caa acc atc tgg att tcc aat384Glu Phe Ala Lys Arg Gln Leu Asn Ala Gln Thr Ile Trp Ile Ser Asn115 120 125ccg act tgg ccc aac cac aac gcc atc gcc aaa gcg gtc ggt atc caa432Pro Thr Trp Pro Asn His Asn Ala Ile Ala Lys Ala Val Gly Ile Gln130 135 140gac caa cct tat cgc tac tat gat gcc gcc aaa cac ggt ttg gat tgg480Asp Gln Pro Tyr Arg Tyr Tyr Asp Ala Ala Lys His Gly Leu Asp Trp145 150 155 160gac ggt atg att gaa gac ttg agc caa gcg caa aaa ggc gac atc gtc528Asp Gly Met Ile Glu Asp Leu Ser Gln Ala Gln Lys Gly Asp Ile Val165 170 175ctg ctg cac ggc tgc tgc cac aac cct acc ggt atc gac cct acg ccc576Leu Leu His Gly Cys Cys His Asn Pro Thr Gly Ile Asp Pro Thr Pro180 185 190gaa caa tgg gaa act ctg gca aaa ctt tct gcc gaa aaa ggc tgg tta624Glu Gln Trp Glu Thr Leu Ala Lys Leu Ser Ala Glu Lys Gly Trp Leu195 200 205ccg ctg ttt gac ttt gcc tac caa ggc ttc ggc aat ggt ttg gaa gaa672Pro Leu Phe Asp Phe Ala Tyr Gln Gly Phe Gly Asn Gly Leu Glu Glu210 215 220gat gcc tac ggc ctg cgc gtg ttc ttg aaa cac aat aca gaa ttg ctg720Asp Ala Tyr Gly Leu Arg Val Phe Leu Lys His Asn Thr Glu Leu Leu225 230 235 240att gcc agc tct tat tcc aaa aac ttc ggt atg tac aac gag cgc gtc768Ile Ala Ser Ser Tyr Ser Lys Asn Phe Gly Met Tyr Asn Glu Arg Val
245 250 255ggc gcg ttc act ttg gtg gcc gaa gat gaa gca acc gcc gcc cgc gcc816Gly Ala Phe Thr Leu Val Ala Glu Asp Glu Ala Thr Ala Ala Arg Ala260 265 270cac agc caa gtc aaa acc att atc cgt acc ttg tat tcc aac cct gct864His Ser Gln Val Lys Thr Ile Ile Arg Thr Leu Tyr Ser Asn Pro Ala275 280 285tca cac ggc gcg aac act att gcg ctg gtg ttg aaa aat gat gat ttg912Ser His Gly Ala Asn Thr Ile Ala Leu Val Leu Lys Asn Asp Asp Leu290 295 300aaa gca caa tgg att gcc gaa ctc gat gaa atg cgc ggc cgt atc aaa960Lys Ala Gln Trp Ile Ala Glu Leu Asp Glu Met Arg Gly Arg Ile Lys305 310 315 320gcc atg cgc caa aaa ttt gtc gag ttg ctc aaa gcc aaa ggt gca act1008Ala Met Arg Gln Lys Phe Val Glu Leu Leu Lys Ala Lys Gly Ala Thr325 330 335caa gac ttt gat ttc att atc gaa caa aac ggc atg ttc tcc ttc agc1056Gln Asp Phe Asp Phe Ile Ile Glu Gln Asn Gly Met Phe Ser Phe Ser340 345 350ggc ttg act ccc gaa caa gtc gac cgt tta aaa aac gag ttt gcc att1104Gly Leu Thr Pro Glu Gln Val Asp Arg Leu Lys Asn Glu Phe Ala Ile355 360 365tat gcc gtc cgc tcc ggc cgc atc aac gtc gcc ggc att acc gac gac1152Tyr Ala Val Arg Ser Gly Arg Ile Asn Val Ala Gly Ile Thr Asp Asp370 375 380aac atc gat tat ctg tgc gaa agt atc gta aaa gta ctg1191Asn Ile Asp Tyr Leu Cys Glu Ser Ile Val Lys Val Leu385 390 395<210>188<211>397<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>188Met Phe Phe Lys His Ile Glu Ala Ala Pro Ala Asp Pro Ile Leu Gly1 5 10 15
Leu Gly Glu Ala Phe Lys Ala Glu Thr Arg Pro Glu Lys Val Asn Leu20 25 30Gly Ile Gly Val Tyr Lys Asp Ala Ser Gly Ala Thr Pro Ile Val Lys35 40 45Ala Val Lys Glu Ala Glu Lys Arg Leu Leu Glu Ser Glu Thr Thr Lys50 55 60Asn Tyr Leu Thr Ile Asp Gly Val Ala Asp Tyr Asn Glu Gln Thr Gln65 70 75 80Ile Leu Leu Phe Gly Lys Asp His Glu Ile Ile Ala Ser Arg Arg Ala85 90 95Lys Thr Ala Gln Ser Leu Gly Gly Thr Gly Ala Leu Arg Ile Ala Ala100 105 110Glu Phe Ala Lys Arg Gln Leu Asn Ala Gln Thr Ile Trp Ile Ser Asn115 120 125Pro Thr Trp Pro Asn His Asn Ala Ile Ala Lys Ala Val Gly Ile Gln130 135 140Asp Gln Pro Tyr Arg Tyr Tyr Asp Ala Ala Lys His Gly Leu Asp Trp145 150 155 160Asp Gly Met Ile Glu Asp Leu Ser Gln Ala Gln Lys Gly Asp Ile Val165 170 175Leu Leu His Gly Cys Cys His Asn Pro Thr Gly Ile Asp Pro Thr Pro180 185 190Glu Gln Trp Glu Thr Leu Ala Lys Leu Ser Ala Glu Lys Gly Trp Leu195 200 205Pro Leu Phe Asp Phe Ala Tyr Gln Gly Phe Gly Asn Gly Leu Glu Glu210 215 220Asp Ala Tyr Gly Leu Arg Val Phe Leu Lys His Asn Thr Glu Leu Leu225 230 235 240Ile Ala Ser Ser Tyr Ser Lys Asn Phe Gly Met Tyr Asn Glu Arg Val245 250 255Gly Ala Phe Thr Leu Val Ala Glu Asp Glu Ala Thr Ala Ala Arg Ala260 265 270
His Ser Gln Val Lys Thr Ile Ile Arg Thr Leu Tyr Ser Asn Pro Ala275 280 285Ser His Gly Ala Asn Thr Ile Ala Leu Val Leu Lys Asn Asp Asp Leu290 295 300Lys Ala Gln Trp Ile Ala Glu Leu Asp Glu Met Arg Gly Arg Ile Lys305 310 315 320Ala Met Arg Gln Lys Phe Val Glu Leu Leu Lys Ala Lys Gly Ala Thr325 330 335Gln Asp Phe Asp Phe Ile Ile Glu Gln Asn Gly Met Phe Ser Phe Ser340 345 350Gly Leu Thr Pro Glu Gln Val Asp Arg Leu Lys Asn Glu Phe Ala Ile355 360 365Tyr Ala Val Arg Ser Gly Arg Ile Asn Val Ala Gly Ile Thr Asp Asp370 375 380Asn Ile Asp Tyr Leu Cys Glu Ser Ile Val Lys Val Leu385 390 395<210>189<211>462<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(462)<400>189ttg ctt tgc ccg gaa aaa atg tcg ggg atg gcg gga cag tat ccg tac48Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr1 5 10 15ggc gtc cgg tcg ggt ttg cgg agg aac ggc ttg aaa ctt tgg gat att96Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile20 25 30cat ttt aga atg acc cgt ttt atc gtc gca aga tgc ggt tta ttg ttt144His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe35 40 45
gca acc ctt aaa gga aaa acc atg aag aaa atg ttc gtg ctg ttc tgt192Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys50 55 60atg ctg ttc tcc tgc gcc ttc tcc ctt gcg gcg gta aac atc aat gcg240Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala65 70 75 80gct tcg cag cag gag ctg gag gcg ctg ccg ggc ata ggc cct gcg aag288Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys85 90 95gcg aag gcc att gcg gaa tac cgt gcg caa aac ggt gcg ttc aag tct336Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser100 105 110gta gac gat ttg acc aag gta aag ggc atc ggc cct gcg gtg ctg gcg384Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala115 120 125aag ctg aag gat cag gct tct gtc ggt gcg ccc gca cca aaa ggc ccg432Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro130 135140gca aaa ccg gct ctg ccc gca gct aaa aaa462Ala Lys Pro Ala Leu Pro Ala Ala Lys Lys145 150<210>190<211>154<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>190Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr1 5 10 15Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile20 25 30His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe35 40 45Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys50 55 60Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala
65 70 75 80Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys85 90 95Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser100 105 110Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala115 120 125Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro130 135 140Ala Lys Pro Ala Leu Pro Ala Ala Lys Lys145 150<210>191<211>684<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(684)<400>191atg ttt gct ttt tta gaa gcc ttt ttt gtc gaa tac ggt tat gcg gct48Met Phe Ala Phe Leu Glu Ala Phe Phe Val Glu Tyr Gly Tyr Ala Ala1 5 10 15gtt ttt ttt gta ttg gtc atc tgc ggt ttc ggc gtg ccg att ccc gag96Val Phe Phe Val Leu Val Ile Cys Gly Phe Gly Val Pro Ile Pro Glu20 25 30gat ttg acc ttg gta aca ggc ggc gtg att tcg ggt atg ggt tat acc144Asp Leu Thr Leu Val Thr Gly Gly Val Ile Ser Gly Met Gly Tyr Thr35 40 45aat ccg cat att atg ttt gca gtc ggt atg ctc ggc gta ttg gtc ggg192Asn Pro His Ile Met Phe Ala Val Gly Met Leu Gly Val Leu Val Gly50 55 60gac ggc atc atg ttc gcc gcc gga cga att tgg ggg cag aaa atc cta240Asp Gly Ile Met Phe Ala Ala Gly Arg Ile Trp Gly Gln Lys Ile Leu65 70 75 80
agg ttc aaa cct att gcg cgc atc atg acg ccg aaa cgt tat gag cag288Arg Phe Lys Pro Ile Ala Arg Ile Met Thr Pro Lys Arg Tyr Glu Gln85 90 95gtt cag gaa aaa ttc gac aaa tac ggt aac tgg gtc tta ttt gtc gcc336Val Gln Glu Lys Phe Asp Lys Tyr Gly Asn Trp Val Leu Phe Val Ala100 105 110cgt ttc ctg ccc ggt ttg aga acg gcc gta ttt gtt aca gcc ggt atc384Arg Phe Leu Pro Gly Leu Arg Thr Ala Val Phe Val Thr Ala Gly Ile115 120 125agc cgc aag gtt tca tac ttg cgt ttt atc att atg gat gga ctg gcc432Ser Arg Lys Val Ser Tyr Leu Arg Phe Ile Ile Met Asp Gly Leu Ala130 135 140gca ctg att tcc gtc cct att tgg att tat ctg ggc gaa tac ggt gcg480Ala Leu Ile Ser Val Pro Ile Trp Ile Tyr Leu Gly Glu Tyr Gly Ala145 150 155 160cac aac atc gat tgg ctg atg gcg aaa atg cac agc ctg caa tcg ggt528His Asn Ile Asp Trp Leu Met Ala Lys Met His Ser Leu Gln Ser Gly165 170 175att ttt gtt atc ttg ggt ata ggt gcg acc gtt gtc gct tgg att tgg576Ile Phe Val Ile Leu Gly Ile Gly Ala Thr Val Val Ala Trp Ile Trp180 185 190tgg aaa aaa cgc caa cgt atc cag ttt tac cgc agc aaa ttg aaa gaa624Trp Lys Lys Arg Gln Arg Ile Gln Phe Tyr Arg ser Lys Leu Lys Glu195 200 205aag cgg gcg caa cgc aaa gcc gcc aag gca gcc aaa aaa gcc gcg caa672Lys Arg Ala Gln Arg Lys Ala Ala Lys Ala Ala Lys Lys Ala Ala Gln210 215 220agc aaa caa taa684Ser Lys Gln225<210>192<211>227<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>192
Met Phe Ala Phe Leu Glu Ala Phe Phe Val Glu Tyr Gly Tyr Ala Ala1 5 10 15Val Phe Phe Val Leu Val Ile Cys Gly Phe Gly Val Pro Ile Pro Glu20 25 30Asp Leu Thr Leu Val Thr Gly Gly Val Ile Ser Gly Met Gly Tyr Thr35 40 45Asn Pro His Ile Met Phe Ala Val Gly Met Leu Gly Val Leu Val Gly50 55 60Asp Gly Ile Met Phe Ala Ala Gly Arg Ile Trp Gly Gln Lys Ile Leu65 70 75 80Arg Phe Lys Pro Ile Ala Arg Ile Met Thr Pro Lys Arg Tyr Glu Gln85 90 95Val Gln Glu Lys Phe Asp Lys Tyr Gly Asn Trp Val Leu Phe Val Ala100 105 110Arg Phe Leu Pro Gly Leu Arg Thr Ala Val Phe Val Thr Ala Gly Ile115 120 125Ser Arg Lys Val Ser Tyr Leu Arg Phe Ile Ile Met Asp Gly Leu Ala130 135 140Ala Leu Ile Ser Val Pro Ile Trp Ile Tyr Leu Gly Glu Tyr Gly Ala145 150 155 160His Asn Ile Asp Trp Leu Met Ala Lys Met His Ser Leu Gln Ser Gly165 170 175Ile Phe Val Ile Leu Gly Ile Gly Ala Thr Val Val Ala Trp Ile Trp180 185 190Trp Lys Lys Arg Gln Arg Ile Gln Phe Tyr Arg Ser Lys Leu Lys Glu195 200 205Lys Arg Ala Gln Arg Lys Ala Ala Lys Ala Ala Lys Lys Ala Ala Gln210 215 220Ser Lys Gln225<210>193
<211>1089<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1089)<400>193atg aat gac tac acg cag cag ctt caa ggt aaa aaa gac tac ctt aaa48Met Asn Asp Tyr Thr Gln Gln Leu Gln Gly Lys Lys Asp Tyr Leu Lys1 5 10 15acc ctt ttt gca ggt ttg gat gtt cct gag tgg gaa gtg tac gaa tct96Thr Leu Phe Ala Gly Leu Asp Val Pro Glu Trp Glu Val Tyr Glu Ser20 25 30ccg gac aaa cat tac cgt atg cgt gcc gag ttc cgt att tgg cac gaa144Pro Asp Lys His Tyr Arg Met Arg Ala Glu Phe Arg Ile Trp His Glu35 40 45ggc ggg gaa atg ttt tat gcc atg ttt gaa aaa ggg cag aaa gcc agc192Gly Gly Glu Met Phe Tyr Ala Met Phe Glu Lys Gly Gln Lys Ala Ser50 55 60ggc gca agc atg ata cgc tgc gac cgt ttt gaa gca gct tcc gag gct240Gly Ala Ser Met Ile Arg Cys Asp Arg Phe Glu Ala Ala Ser Glu Ala65 70 75 80gtc aac cgc ctc atg ccc gag ctg atc gcc gcc gcc gcg caa tcc ccc288Val Asn Arg Leu Met Pro Glu Leu Ile Ala Ala Ala Ala Gln Ser Pro85 90 95gaa ctc aaa aaa cgc tgg tat gcc gtc gaa ttt ctg tcc acg ctc agc336Glu Leu Lys Lys Arg Trp Tyr Ala Val Glu Phe Leu Ser Thr Leu Ser100 105 110ggg gaa atg ctg gtt acc atg att tac cac aaa agg ctt gat gct gag384Gly Glu Met Leu Val Thr Met Ile Tyr His Lys Arg Leu Asp Ala Glu115 120 125tgg atg cag gcg gcg caa gcg tta cag caa cag ttg gat att tcc gtt432Trp Met Gln Ala Ala Gln Ala Leu Gln Gln Gln Leu Asp Ile Ser Val130 135 140att ggg cgg agc agg gga cag aaa ata gtc tta aaa cag gac tat gta480Ile Gly Arg Ser Arg Gly Gln Lys Ile Val Leu Lys Gln Asp Tyr Val145 150 155 160
acg gaa act ttg aag gtc ggc aac cgg gat ttc cgt tat cgg caa att528Thr Glu Thr Leu Lys Val Gly Asn Arg Asp Phe Arg Tyr Arg Gln Ile165 170 175gaa ggc agt ttt acc caa ccg aat gcc gcc gtg tgt cag aaa atg ctt576Glu Gly Ser Phe Thr Gln Pro Asn Ala Ala Val Cys Gln Lys Met Leu180 185 190gaa tgg gcg tgc cgc acg gcg gaa ggc ttg ggc agc gac ctg ctc gaa624Glu Trp Ala Cys Arg Thr Ala Glu Gly Leu Gly Ser Asp Leu Leu Glu195 200 205ctg tat tgc gga aac ggc aat ttc acc ctg ccg ctg tcc cga tat ttc672Leu Tyr Cys Gly Asn Gly Asn Phe Thr Leu Pro Leu Ser Arg Tyr Phe210 215 220cga cag gtt ttg gca acc gaa atc tcc aaa acc tcc gtc agc gcg gcg720Arg Gln Val Leu Ala Thr Glu Ile Ser Lys Thr Ser Val Ser Ala Ala225 230 235 240caa tgg aat atc gaa gcc aac cgc atc ggc aac atc aaa atc gcc cgt768Gln Trp Asn Ile Glu Ala Asn Arg Ile Gly Asn Ile Lys Ile Ala Arg245 250 255ctg tct gct gaa gaa ttt acc gaa gcc tat acc gga aaa cgt gag ttt816Leu Ser Ala Glu Glu Phe Thr Glu Ala Tyr Thr Gly Lys Arg Glu Phe260 265 270aaa cgc ctt aag gat ggc ggt att gct ttg acg gat tac gca ttt tcc864Lys Arg Leu Lys Asp Gly Gly Ile Ala Leu Thr Asp Tyr Ala Phe Ser275 280 285act att ttc gtc gat ccg ccg cgt gcc ggt atc gat gag gaa act ttg912Thr Ile Phe Val Asp Pro Pro Arg Ala Gly Ile Asp Glu Glu Thr Leu290 295 300aag ctg gtg tcg cag ttt gac aac atc atc tac att tcc tgc aat ccc960Lys Leu Val Ser Gln Phe Asp Asn Ile Ile Tyr Ile Ser Cys Asn Pro305 310 315 320gaa acg ttg cgc gcc aat ttg gac acc ttg gcg gaa acc cat gcg gtc1008Glu Thr Leu Arg Ala Asn Leu Asp Thr Leu Ala Glu Thr His Ala Val325 330 335gaa cgt gcc gcc ctg ttc gac caa ttc ccg ttt acg cac cat atc gaa1056Glu Arg Ala Ala Leu Phe Asp Gln Phe Pro Phe Thr His His Ile Glu340 345 350
agt ggt gta ttg ttg aaa aag aaa atc ctt tga 1089Ser Gly Val Leu Leu Lys Lys Lys Ile Leu355 360<210>194<211>362<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>194Met Asn Asp Tyr Thr Gln Gln Leu Gln Gly Lys Lys Asp Tyr Leu Lys1 5 10 15Thr Leu Phe Ala Gly Leu Asp Val Pro Glu Trp Glu Val Tyr Glu Ser20 25 30Pro Asp Lys His Tyr Arg Met Arg Ala Glu Phe Arg Ile Trp His Glu35 40 45Gly Gly Glu Met Phe Tyr Ala Met Phe Glu Lys Gly Gln Lys Ala Ser50 55 60Gly Ala Ser Met Ile Arg Cys Asp Arg Phe Glu Ala Ala Ser Glu Ala65 70 75 80Val Asn Arg Leu Met Pro Glu Leu Ile Ala Ala Ala Ala Gln Ser Pro85 90 95Glu Leu Lys Lys Arg Trp Tyr Ala Val GIu Phe Leu Ser Thr Leu Ser100 105 110Gly Glu Met Leu Val Thr Met Ile Tyr His Lys Arg Leu Asp Ala Glu115 120 125Trp Met Gln Ala Ala Gln Ala Leu Gln Gln Gln Leu Asp Ile Ser Val130 135 140Ile Gly Arg Ser Arg Gly Gln Lys Ile Val Leu Lys Gln Asp Tyr Val145 150 155 160Thr Glu Thr Leu Lys Val Gly Asn Arg Asp Phe Arg Tyr Arg Gln Ile165 170 175Glu Gly Ser Phe Thr Gln Pro Asn Ala Ala Val Cys Gln Lys Met Leu180 185 190
Glu Trp Ala Cys Arg Thr Ala Glu Gly Leu Gly Ser Asp Leu Leu Glu195 200 205Leu Tyr Cys Gly Asn Gly Asn Phe Thr Leu Pro Leu Ser Arg Tyr Phe210 215 220Arg Gln Val Leu Ala Thr Glu Ile Ser Lys Thr Ser Val Ser Ala Ala225 230 235 240Gln Trp Asn Ile Glu Ala Asn Arg Ile Gly Asn Ile Lys Ile Ala Arg245 250 255Leu Ser Ala Glu Glu Phe Thr Glu Ala Tyr Thr Gly Lys Arg Glu Phe260 265 270Lys Arg Leu Lys Asp Gly Gly Ile Ala Leu Thr Asp Tyr Ala Phe Ser275 280 285Thr Ile Phe Val Asp Pro Pro Arg Ala Gly Ile Asp Glu Glu Thr Leu290 295 300Lys Leu Val Ser Gln Phe Asp Asn Ile Ile Tyr Ile Ser Cys Asn Pro305 310 315 320Glu Thr Leu Arg Ala Asn Leu Asp Thr Leu Ala Glu Thr His Ala Val325 330 335Glu Arg Ala Ala Leu Phe Asp Gln Phe Pro Phe Thr His His Ile Glu340 345 350Ser Gly Val Leu Leu Lys Lys Lys Ile Leu355 360<210>195<211>2145<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(2145)<400>195atg aat acc cca ttg ttc cgt ctc agc ctg ctc tcg ctt acc ctg gcg48Met Asn Thr Pro Leu Phe Arg Leu Ser Leu Leu Ser Leu Thr Leu Ala1 5 10 15
gca ggt ttt gcc cat gcg gca gaa aat aat gcc aag gtc gta ctg gat96Ala Gly Phe Ala His Ala Ala Glu Asn Asn Ala Lys Val Val Leu Asp20 25 30acc gtt acc gta aaa ggc gac cgc caa ggc agc aaa atc cgt acc aac144Thr Val Thr Val Lys Gly Asp Arg Gln Gly Ser Lys Ile Arg Thr Asn35 40 45atc gtt acg ctg caa caa aaa gac gaa agc acc gca acc gat atg cgc192Ile Val Thr Leu Gln Gln Lys Asp Glu Ser Thr Ala Thr Asp Met Arg50 55 60gaa ctc tta aaa gaa gag ccc tcc atc gat ttc ggc ggc ggc aac ggc240Glu Leu Leu Lys Glu Glu Pro Ser Ile Asp Phe Gly Gly Gly Asn Gly65 70 75 80acg tcc caa ttc ctg acg ctg cgc ggc atg ggt caa aac tct gtc gac288Thr Ser Gln Phe Leu Thr Leu Arg Gly Met Gly Gln Asn Ser Val Asp85 90 95atc aag gtg gac aac gcc tat tcc gac agc caa atc ctt tac cac caa336Ile Lys Val Asp Asn Ala Tyr Ser Asp Ser Gln Ile Leu Tyr His Gln100 105 110ggc aga ttt att gtc gat ccc gct ttg gtt aaa gtc gtt tcc gta caa384Gly Arg Phe Ile Val Asp Pro Ala Leu Val Lys Val Val Ser Val Gln115 120 125aaa ggc gcg ggt tcc gcc tct gcc ggt atc ggc gcg acc aac ggc gcg432Lys Gly Ala Gly Ser Ala Ser Ala Gly Ile Gly Ala Thr Asn Gly Ala130 135 140atc atc acc aaa acc gtc gat gcc caa gac ctg ctc aaa ggc ttg gat480Ile Ile Thr Lys Thr Val Asp Ala Gln Asp Leu Leu Lys Gly Leu Asp145 150 155 160aaa aac tgg ggc gtg cgc ctc aac agc ggc ttt gcc agc aac gaa ggc528Lys Asn Trp Gly Val Arg Leu Asn Ser Gly Phe Ala Ser Asn Glu Gly165 170 175gta agc tac ggc gca agc gta ttc ggg aaa gag ggc aac ttc gac ggc576Val Ser Tyr Gly Ala Ser Val Phe Gly Lys Glu Gly Asn Phe Asp Gly180 185 190ttg ttc tct tac aac cgc aac aat gaa aaa gat tac gaa gca ggt aaa624Leu Phe Ser Tyr Asn Arg Asn Asn Glu Lys Asp Tyr Glu Ala Gly Lys195 200 205
ggc ttc cgt aat aat ttc aac ggc ggc aaa acc gta ccg tac agc gcg672Gly Phe Arg Asn Asn Phe Asn Gly Gly Lys Thr Val Pro Tyr Ser Ala210 215 220ctg gac aaa cgc agc tac ctc gcc aaa atc gga aca agc ttc ggc gac720Leu Asp Lys Arg Ser Tyr Leu Ala Lys Ile Gly Thr Ser Phe Gly Asp225 230 235 240ggc gac cac cgc atc gta ttg agc cat atg aaa gac cag cac cgg ggc768Gly Asp His Arg Ile Val Leu Ser His Met Lys Asp Gln His Arg Gly245 250 255atc cgt acc gtc cgt gaa gaa ttt acc gtc ggc ggc gat aaa gag cga816Ile Arg Thr Val Arg Glu Glu Phe Thr Val Gly Gly Asp Lys Glu Arg260 265 270ata agt atg gaa cgc caa gcc cct gct tac cgc gaa acc aca caa tcc864Ile Ser Met Glu Arg Gln Ala Pro Ala Tyr Arg Glu Thr Thr Gln Ser275 280 285aac acc aat ttg gcg tac acg ggt aaa aac ctg ggc ttt gtc gaa aaa912Asn Thr Asn Leu Ala Tyr Thr Gly Lys Asn Leu Gly Phe Val Glu Lys290 295 300ctg gat gcc aac gcc tat gtg ttg gaa aaa gaa cgc tat tcc gcc gat960Leu Asp Ala Asn Ala Tyr Val Leu Glu Lys Glu Arg Tyr Ser Ala Asp305 310 315 320gac agc ggc acc ggt tac gca ggc aat gta aaa ggc ccc aac cat acc1008Asp Ser Gly Thr Gly Tyr Ala Gly Asn Val Lys Gly Pro Asn His Thr325 330 335caa atc acc act cgg ggt atg aac ttc aac ttc gac agc cgc ctt gcc1056Gln Ile Thr Thr Arg Gly Met Asn Phe Asn Phe Asp Ser Arg Leu Ala340 345 350gaa caa acc ctg ctg aaa tac ggt atc aac tac cgc cat cag gaa atc1104Glu Gln Thr Leu Leu Lys Tyr Gly Ile Asn Tyr Arg His Gln Glu Ile355 360 365aaa ccg caa gcg ttt ttg aat tca caa ttt aaa att gaa gat aaa gaa1152Lys Pro Gln Ala Phe Leu Asn Ser Gln Phe Lys Ile Glu Asp Lys Glu370 375 380aaa gca act gat gaa gag aaa aat aag aac cgt gaa aat gaa aaa att1200Lys Ala Thr Asp Glu Glu Lys Asn Lys Asn Arg Glu Asn Glu Lys Ile385 390 395 400
gcc aaa gcc tac cgt ctg acc aac ccg acc aaa acc gat acc ggc gcg1248Ala Lys Ala Tyr Arg Leu Thr Asn Pro Thr Lys Thr Asp Thr Gly Ala405 410 415tat atc gaa gcc att cac gag att gac ggc ttt acc ctg acc ggc ggg1296Tyr Ile Glu Ala Ile His Glu Ile Asp Gly Phe Thr Leu Thr Gly Gly420 425 430ctg cgt tac gac cgc ttc aag gtg aaa acc cac gac ggc aaa acc gtt1344Leu Arg Tyr Asp Arg Phe Lys Val Lys Thr His Asp Gly Lys Thr Val435 440 445tca agc aac aac ctt aac ccg agt ttc ggc gtg att tgg cag ccg cac1392Ser Ser Asn Asn Leu Asn Pro Ser Phe Gly Val Ile Trp Gln Pro His450 455 460gaa cac tgg agc ttc agc gcg agc cac aac tac gcc agc cgc agc ccg1440Glu His Trp Ser Phe Ser Ala Ser His Asn Tyr Ala Ser Arg Ser Pro465 470 475 480cgc ctg tat gac gcg ctg caa acc cac ggc aaa cgc ggc atc atc tcg1488Arg Leu Tyr Asp Ala Leu Gln Thr His Gly Lys Arg Gly Ile Ile Ser485 490 495att gcc gac ggc acg aaa gcc gaa cgc gcg cgc aat acc gaa atc ggc1536Ile Ala Asp Gly Thr Lys Ala Glu Arg Ala Arg Asn Thr Glu Ile Gly500 505 510ttc aac tac aac gac ggc acg ttt gcc gca aac ggc agc tac ttc tgg1584Phe Asn Tyr Asn Asp Gly Thr Phe Ala Ala Asn Gly Ser Tyr Phe Trp515 520 525cag acc atc aaa gac gcg ctt gcc aat ccg caa aac cgc cac gac tct1632Gln Thr Ile Lys Asp Ala Leu Ala Asn Pro Gln Asn Arg His Asp Ser530 535 540gtc gcc gtc cgt gaa gcc gtc aat gcc ggt tac atc aaa aac cac ggt1680Val Ala Val Arg Glu Ala Val Asn Ala Gly Tyr Ile Lys Asn His Gly545 550 555 560tac gaa ttg ggc gcg tcc tac cgc acc ggc ggc ctg act gcc aaa gtc1728Tyr Glu Leu Gly Ala Ser Tyr Arg Thr Gly Gly Leu Thr Ala Lys Val565 570 575ggc gta agc cac agc aaa ccg cgc ttt tac gat acg cac aaa gac aag1776Gly Val Ser His Ser Lys Pro Arg Phe Tyr Asp Thr His Lys Asp Lys580 585 590
ctg ttg agc gcg aat cct gaa ttt ggc gca caa gtc ggc cgc act tgg1824Leu Leu Ser Ala Asn Pro Glu Phe Gly Ala Gln Val Gly Arg Thr Trp595 600 605acg gct tcc ctt gcc tac cgc ttc caa aac ccg aat ctg gaa atc ggc1872Thr Ala Ser Leu Ala Tyr Arg Phe Gln Asn Pro Asn Leu Glu Ile Gly610 615 620tgg cgc ggc cgt tat gtt caa aaa gcc gtg ggt tcg ata ttg gtg gca1920Trp Arg Gly Arg Tyr Val Gln Lys Ala Val Gly Ser Ile Leu Val Ala625 630 635 640ggt caa aaa gac cgc aac ggc aaa ttg gaa aac gtt gta cgc aaa ggt1968Gly Gln Lys Asp Arg Asn Gly Lys Leu Glu Asn Val Val Arg Lys Gly645 650 655ttc ggt gtg aac gat gtc ttc gcc aac tgg aaa ccg ctg ggc aaa gac2016Phe Gly Val Asn Asp Val Phe Ala Asn Trp Lys Pro Leu Gly Lys Asp660 665 670acg ctc aat gtt aat ctt tcg gtt aac aac gtg ttc aac acg ttc tac2064Thr Leu Asn Val Asn Leu Ser Val Asn Asn Val Phe Asn Thr Phe Tyr675 680 685tat ccg cac agc caa cga tgg acc aat acc ctg ccg ggc gtg gga cgt2112Tyr Pro His Ser Gln Arg Trp Thr Asn Thr Leu Pro Gly Val Gly Arg690 695 700gat gta cgc ttg ggc gtg aac tac aag ttc taa2145Asp Val Arg Leu Gly Val Asn Tyr Lys Phe705 710 715<210>196<211>714<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>196Met Asn Thr Pro Leu Phe Arg Leu Ser Leu Leu Ser Leu Thr Leu Ala1 5 10 15Ala Gly Phe Ala His Ala Ala Glu Asn Asn Ala Lys Val Val Leu Asp20 25 30Thr Val Thr Val Lys Gly Asp Arg Gln Gly Ser Lys Ile Arg Thr Asn35 40 45
Ile Val Thr Leu Gln Gln Lys Asp Glu Ser Thr Ala Thr Asp Met Arg50 55 60Glu Leu Leu Lys Glu Glu Pro Ser Ile Asp Phe Gly Gly Gly Asn Gly65 70 75 80Thr Ser Gln Phe Leu Thr Leu Arg Gly Met Gly Gln Asn Ser Val Asp85 90 95Ile Lys Val Asp Asn Ala Tyr Ser Asp Ser Gln Ile Leu Tyr His Gln100 105 110Gly Arg Phe Ile Val Asp Pro Ala Leu Val Lys Val Val Ser Val Gln115 120 125Lys Gly Ala Gly Ser Ala Ser Ala Gly Ile Gly Ala Thr Asn Gly Ala130 135 140Ile Ile Thr Lys Thr Val Asp Ala Gln Asp Leu Leu Lys Gly Leu Asp145 150 155 160Lys Asn Trp Gly Val Arg Leu Asn Ser Gly Phe Ala Ser Asn Glu Gly165 170 175Val Ser Tyr Gly Ala Ser Val Phe Gly Lys Glu Gly Asn Phe Asp Gly180 185 190Leu Phe Ser Tyr Asn Arg Asn Asn Glu Lys Asp Tyr Glu Ala Gly Lys195 200 205Gly Phe Arg Asn Asn Phe Asn Gly Gly Lys Thr Val Pro Tyr Ser Ala210 215 220Leu Asp Lys Arg Ser Tyr Leu Ala Lys Ile Gly Thr Ser Phe Gly Asp225 230 235 240Gly Asp His Arg Ile Val Leu Ser His Met Lys Asp Gln His Arg Gly245 250 255Ile Arg Thr Val Arg Glu Glu Phe Thr Val Gly Gly Asp Lys Glu Arg260 265 270Ile Ser Met Glu Arg Gln Ala Pro Ala Tyr Arg Glu Thr Thr Gln Ser275 280 285Asn Thr Asn Leu Ala Tyr Thr Gly Lys Asn Leu Gly Phe Val Glu Lys290 295 300
Leu Asp Ala Asn Ala Tyr Val Leu Glu Lys Glu Arg Tyr Ser Ala Asp305 310 315 320Asp Ser Gly Thr Gly Tyr Ala Gly Asn Val Lys Gly Pro Asn His Thr325 330 335Gln Ile Thr Thr Arg Gly Met Asn Phe Asn Phe Asp Ser Arg Leu Ala340 345 350Glu Gln Thr Leu Leu Lys Tyr Gly Ile Asn Tyr Arg His Gln Glu Ile355 360 365Lys Pro Gln Ala Phe Leu Asn Ser Gln Phe Lys Ile Glu Asp Lys Glu370 375 380Lys Ala Thr Asp Glu Glu Lys Asn Lys Asn Arg Glu Asn Glu Lys Ile385 390 395 400Ala Lys Ala Tyr Arg Leu Thr Asn Pro Thr Lys Thr Asp Thr Gly Ala405 410 415Tyr Ile Glu Ala Ile His Glu Ile Asp Gly Phe Thr Leu Thr Gly Gly420 425 430Leu Arg Tyr Asp Arg Phe Lys Val Lys Thr His Asp Gly Lys Thr Val435 440 445Ser Ser Asn Asn Leu Asn Pro Ser Phe Gly Val Ile Trp Gln Pro His450 455 460Glu His Trp Ser Phe Ser Ala Ser His Asn Tyr Ala Ser Arg Ser Pro465 470 475 480Arg Leu Tyr Asp Ala Leu Gln Thr His Gly Lys Arg Gly Ile Ile Ser485 490 495Ile Ala Asp Gly Thr Lys Ala Glu Arg Ala Arg Asn Thr Glu Ile Gly500 505 510Phe Asn Tyr Asn Asp Gly Thr Phe Ala Ala Asn Gly Ser Tyr Phe Trp515 520 525Gln Thr Ile Lys Asp Ala Leu Ala Asn Pro Gln Asn Arg His Asp Ser530 535 540Val Ala Val Arg Glu Ala Val Asn Ala Gly Tyr Ile Lys Asn His Gly545 550 555 560
Tyr Glu Leu Gly Ala Ser Tyr Arg Thr Gly Gly Leu Thr Ala Lys Val565 570 575Gly Val Ser His Ser Lys Pro Arg Phe Tyr Asp Thr His Lys Asp Lys580 585 590Leu Leu Ser Ala Asn Pro Glu Phe Gly Ala Gln Val Gly Arg Thr Trp595 600 605Thr Ala Ser Leu Ala Tyr Arg Phe Gln Asn Pro Asn Leu Glu Ile Gly610 615 620Trp Arg Gly Arg Tyr Val Gln Lys Ala Val Gly Ser Ile Leu Val Ala625 630 635 640Gly Gln Lys Asp Arg Asn Gly Lys Leu Glu Asn Val Val Arg Lys Gly645 650 655Phe Gly Val Asn Asp Val Phe Ala Asn Trp Lys Pro Leu Gly Lys Asp660 665 670Thr Leu Asn Val Asn Leu Ser Val Asn Asn Val Phe Asn Thr Phe Tyr675 680 685Tyr Pro His Ser Gln Arg Trp Thr Asn Thr Leu Pro Gly Val Gly Arg690 695 700Asp Val Arg Leu Gly Val Asn Tyr Lys Phe705 710<210>197<211>2625<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(2625)<400>197atg aaa acc tcc gaa ctg cgc caa aaa ttc cta aaa ttt ttt gaa acc48Met Lys Thr Ser Glu Leu Arg Gln Lys Phe Leu Lys Phe Phe Glu Thr1 5 10 15aaa ggc cac acc gtc gtc cgc tct tcc agc ctc gtg ccg cac gac gac96
Lys Gly His Thr Val Val Arg Ser Ser Ser Leu Val Pro His Asp Asp20 25 30ccg acc ctg ctg ttt acc aac gcg ggc atg aac cag ttt aaa gac gta144Pro Thr Leu Leu Phe Thr Asn Ala Gly Met Asn Gln Phe Lys Asp Val35 40 45ttc tta ggt ttc gac aaa cgc ccg tac agc cgc gcc acc acc gcg caa192Phe Leu Gly Phe Asp Lys Arg Pro Tyr Ser Arg Ala Thr Thr Ala Gln50 55 60aaa tgc gta cgc gca ggc ggc aaa cac aac gac ttg gaa aac gtc ggc240Lys Cys Val Arg Ala Gly Gly Lys His Asn Asp Leu Glu Asn Val Gly65 70 75 80tac acc gcc cgc cac cac acc ttc ttt gaa atg atg ggc aac ttc tcc288Tyr Thr Ala Arg His His Thr Phe Phe Glu Met Met Gly Asn Phe Ser85 90 95ttc ggc gac tac ttc aaa cgc gac gcc atc cac ttc gct tgg gaa ttt336Phe Gly Asp Tyr Phe Lys Arg Asp Ala Ile His Phe Ala Trp Glu Phe100 105 110ctg act tcc ccc gaa tgg ctc aac atc cct aaa gac aaa ctg ttg gcg384Leu Thr Ser Pro Glu Trp Leu Asn Ile Pro Lys Asp Lys Leu Leu Ala115 120 125acc gtt tac gcg gaa gac gac gaa gcc tac aac atc tgg ttg aac gaa432Thr Val Tyr Ala Glu Asp Asp Glu Ala Tyr Asn Ile Trp Leu Asn Glu130 135 140atc ggt atg ccg tcc gag cgc atc gtc cgc atc ggc gac aac aaa ggc480Ile Gly Met Pro Ser Glu Arg Ile Val Arg Ile Gly Asp Asn Lys Gly145 150 155 160gcg aaa tac gca tcc gac aac ttc tgg caa atg ggc gac acc ggc cct528Ala Lys Tyr Ala Ser Asp Asn Phe Trp Gln Met Gly Asp Thr Gly Pro165 170 175tgc ggc ccc tgc tcc gaa att ttc tac gac cac ggc gaa gaa atc tgg576Cys Gly Pro Cys Ser Glu Ile Phe Tyr Asp His Gly Glu Glu Ile Trp180 185 190ggc ggc att ccc ggc agt ccc gaa gaa gac ggc gac cgc tgg atc gaa624Gly Gly Ile Pro Gly Ser Pro Glu Glu Asp Gly Asp Arg Trp Ile Glu195 200 205att tgg aac tgc gta ttt atg cag ttc aac cgc gac gaa caa ggc aat672
Ile Trp Asn Cys Val Phe Met Gln Phe Asn Arg Asp Glu Gln Gly Asn210 215 220atg aac ccg ctt ccc aaa cct tcc gtc gat acc ggt atg ggc ttg gaa720Met Asn Pro Leu Pro Lys Pro Ser Val Asp Thr Gly Met Gly Leu Glu225 230 235 240cgc ata gcc gcc gtc atg cag cat gtt cac agc aac tac gaa atc gac768Arg Ile Ala Ala Val Met Gln His Val His Ser Asn Tyr Glu Ile Asp245 250 255ttg ttc caa gac ctg ctc aaa gcc gtt gcc cgc gaa acc ggc gcg ccg816Leu Phe Gln Asp Leu Leu Lys Ala Val Ala Arg Glu Thr Gly Ala Pro260 265 270ttc aga atg gaa gaa ccc agc ctg aaa gtc atc gcc gac cac atc cgc864Phe Arg Met Glu Glu Pro Ser Leu Lys Val Ile Ala Asp His Ile Arg275 280 285tcc tgc tcg ttc ctg att gca gac ggc gtc ttg cct tcc aac gaa ggc912Ser Cys Ser Phe Leu Ile Ala Asp Gly Val Leu Pro Ser Asn Glu Gly290 295 300cgc ggc tac gta ttg cgc cgc att atc cgc cgc gcc gtg cgc cac ggt960Arg Gly Tyr Val Leu Arg Arg Ile Ile Arg Arg Ala Val Arg His Gly305 310 315 320tac aaa ctg ggt caa agc aaa ccg ttc ttc cac aaa ctc gtt gcc gat1008Tyr Lys Leu Gly Gln Ser Lys Pro Phe Phe His Lys Leu Val Ala Asp325 330 335ttg gtc aaa gag atg ggc ggt gcc tac cct gaa ttg aaa gaa aaa caa1056Leu Val Lys Glu Met Gly Gly Ala Tyr Pro Glu Leu Lys Glu Lys Gln340 345 350gcc caa atc gaa gaa gca ttg aaa aac gaa gaa agc cgt ttt gcc caa1104Ala Gln Ile Glu Glu Ala Leu Lys Asn Glu Glu Ser Arg Phe Ala Gln355 360 365acg ctg gaa acc ggt atg gct ttg ttg gaa aac gcg ctg gtc aaa ggc1152Thr Leu Glu Thr Gly Met Ala Leu Leu Glu Asn Ala Leu Val Lys Gly370 375 380ggc aaa aca ctc ggc ggc gaa atc atc ttc aaa ctc tac gat acc tac1200Gly Lys Thr Leu Gly Gly Glu Ile Ile Phe Lys Leu Tyr Asp Thr Tyr385 390 395 400ggt ttc cca tac gac ttg act gcc gac atc tgc cgc gaa cgc aat atc1248
Gly Phe Pro Tyr Asp Leu Thr Ala Asp Ile Cys Arg Glu Arg Asn Ile405 410 415gaa ccg gac gaa gca ggc ttc gag cgc gaa atg gaa gcc caa cgc gca1296Glu Pro Asp Glu Ala Gly Phe Glu Arg Glu Met Glu Ala Gln Arg Ala420 425 430cgc gca cgc gcc gcc caa agc ttc aaa gcc aac gcc caa ctg cct tat1344Arg Ala Arg Ala Ala Gln Ser Phe Lys Ala Asn Ala Gln Leu Pro Tyr435 440 445gac ggt caa gac acc gag ttt aaa ggt tat agc gaa cgc caa acc gaa1392Asp Gly Gln Asp Thr Glu Phe Lys Gly Tyr Ser Glu Arg Gln Thr Glu450 455 460tcc aaa gtc ctc gcc ctc tac aaa gac ggc gag caa gtc aac gaa ttg1440Ser Lys Val Leu Ala Leu Tyr Lys Asp Gly Glu Gln Val Asn Glu Leu465 470 475 480aac gaa ggc gac agc ggc gca gtc gtc atc gac ttt acc ccg ttc tat1488Asn Glu Gly Asp Ser Gly Ala Val Val Ile Asp Phe Thr Pro Phe Tyr485 490 495gca gaa tcc ggc ggc caa gtc ggc gat gtc ggc tat atc ttc tca ggc1536Ala Glu Ser Gly Gly Gln Val Gly Asp Val Gly Tyr Ile Phe Ser Gly500 505 510gaa aac cgc ttt gaa gta cgc gat acc caa aaa atc aaa gcg gcc gta1584Glu Asn Arg Phe Glu Val Arg Asp Thr Gln Lys Ile Lys Ala Ala Val515 520 525ttc ggt caa ttc ggc gta caa act tca ggc cgt ctg aaa gtc ggc gac1632Phe Gly Gln Phe Gly Val Gln Thr Ser Gly Arg Leu Lys Val Gly Asp530 535 540agc gtt acc gcc aaa gtg gac gac gaa atc cgc aat gcc aat atg cgc1680Ser Val Thr Ala Lys Val Asp Asp Glu Ile Arg Asn Ala Asn Met Arg545 550 555 560aac cac agc gca acc cac ttg atg cac aaa gcc ctg cgc gat gta ttg1728Asn His Ser Ala Thr His Leu Met His Lys Ala Leu Arg Asp Val Leu565 570 575ggc aga cac gtc gaa caa aaa ggc tct ttg gtt acc gcc gaa tcc acc1776Gly Arg His Val Glu Gln Lys Gly Ser Leu Val Thr Ala Glu Ser Thr580 585 590cgt ttc gac att tcc cat ccc caa gcg gta act gcc gaa gaa att gcc1824
Arg Phe Asp Ile Ser His Pro Gln Ala Val Thr Ala Glu Glu Ile Ala595 600 605gaa gta gaa cgc cgc gtc aac gaa gcc att ttg gcg aac gtt gcc gtc1872Glu Val Glu Arg Arg Val Asn Glu Ala Ile Leu Ala Asn Val Ala Val610 615 620aat gca gcc att atg agc atg gaa gac gcg caa aaa acc ggc gcg atg1920Asn Ala Ala Ile Met Ser Met Glu Asp Ala Gln Lys Thr Gly Ala Met625 630 635 640atg ctc ttc ggc gaa aaa tac ggc gaa gaa gtg cgc gta ctg caa atg1968Met Leu Phe Gly Glu Lys Tyr Gly Glu Glu Val Arg Val Leu Gln Met645 650 655ggc ggt ttc tct acc gaa ttg tgc ggc ggc aca cac gtt tca cgc acc2016Gly Gly Phe Ser Thr Glu Leu Cys Gly Gly Thr His Val Ser Arg Thr660 665 670ggc gac atc ggc ctc ttc aaa atc atc agc gaa ggc ggt att gcc gca2064Gly Asp Ile Gly Leu Phe Lys Ile Ile Ser Glu Gly Gly Ile Ala Ala675 680 685ggc gtg cgc cgt atc gaa gcc atc acc ggc ctg aac gca ctc aaa tgg2112Gly Val Arg Arg Ile Glu Ala Ile Thr Gly Leu Asn Ala Leu Lys Trp690 695 700gcg caa gag caa gag cgt ttg gtg aaa gac att att gcc gaa acc aaa2160Ala Gln Glu Gln Glu Arg Leu Val Lys Asp Ile Ile Ala Glu Thr Lys705 710 715 720gcc caa acc gaa aaa gac gta ctg gca aaa atc caa gca ggc gcg gca2208Ala Gln Thr Glu Lys Asp Val Leu Ala Lys Ile Gln Ala Gly Ala Ala725 730 735cac gcc aaa gca ttg gaa aaa gaa ttg gca cgc gcc aaa gcc gaa ctc2256His Ala Lys Ala Leu Glu Lys Glu Leu Ala Arg Ala Lys Ala Glu Leu740 745 750gcc gtc cac gca ggc gcc aaa ctc ttg gac gat gca aaa gac ttg ggc2304Ala Val His Ala Gly Ala Lys Leu Leu Asp Asp Ala Lys Asp Leu Gly755 760 765gca gcc aaa ctc gtt gcc gcc caa atc gaa gcc gac gca gcc gcc ctg2352Ala Ala Lys Leu Val Ala Ala Gln Ile Glu Ala Asp Ala Ala Ala Leu770 775 780cgc gaa atc gtt acc gat tta acc ggt aaa tcc gac aac gcc gtg att2400
Arg Glu Ile Val Thr Asp Leu Thr Gly Lys Ser Asp Asn Ala Val Ile785 790 795 800ctt tta gcg gca gta aac gac ggc aaa gtc tcc ctg tgc gcc ggc gta2448Leu Leu Ala Ala Val Asn Asp Gly Lys Val Ser Leu Cys Ala Gly Val805 810 815tcc aaa ccg ttg acc ggc aaa gtg aaa gca ggc gat ctg gtt aaa ttt2496Ser Lys Pro Leu Thr Gly Lys Val Lys Ala Gly Asp Leu Val Lys Phe820 825 830gca gcc gaa caa gtc ggc ggc aaa ggc ggc ggc aga cca gat ttg gcg2544Ala Ala Glu Gln Val Gly Gly Lys Gly Gly Gly Arg Pro Asp Leu Ala835 840 845caa gcc ggc ggc acg gat gcc gac aaa ttg ccc gcc gtg ttg gat agc2592Gln Ala Gly Gly Thr Asp Ala Asp Lys Leu Pro Ala Val Leu Asp Ser850 855 860gtg aaa gac tgg gtc ggc gcg aag ctg gtt tga2625Val Lys Asp Trp Val Gly Ala Lys Leu Val865 870 875<210>198<211>874<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>198Met Lys Thr Ser Glu Leu Arg Gln Lys Phe Leu Lys Phe Phe Glu Thr1 5 10 15Lys Gly His Thr Val Val Arg Ser Ser Ser Leu Val Pro His Asp Asp20 25 30Pro Thr Leu Leu Phe Thr Asn Ala Gly Met Asn Gln Phe Lys Asp Val35 40 45Phe Leu Gly Phe Asp Lys Arg Pro Tyr Ser Arg Ala Thr Thr Ala Gln50 55 60Lys Cys Val Arg Ala Gly Gly Lys His Asn Asp Leu Glu Asn Val Gly65 70 75 80Tyr Thr Ala Arg His His Thr Phe Phe Glu Met Met Gly Asn Phe Ser85 90 95
Phe Gly Asp Tyr Phe Lys Arg Asp Ala Ile His Phe Ala Trp Glu Phe100 105 110Leu Thr Ser Pro Glu Trp Leu Asn Ile Pro Lys Asp Lys Leu Leu Ala115 120 125Thr Val Tyr Ala Glu Asp Asp Glu Ala Tyr Asn Ile Trp Leu Asn Glu130 135 140Ile Gly Met Pro Ser Glu Arg Ile Val Arg Ile Gly Asp Asn Lys Gly145 150 155 160Ala Lys Tyr Ala Ser Asp Asn Phe Trp Gln Met Gly Asp Thr Gly Pro165 170 175Cys Gly Pro Cys Ser Glu Ile Phe Tyr Asp His Gly Glu Glu Ile Trp180 185 190Gly Gly Ile Pro Gly Ser Pro Glu Glu Asp Gly Asp Arg Trp Ile Glu195 200 205Ile Trp Asn Cys Val Phe Met Gln Phe Asn Arg Asp Glu Gln Gly Asn210 215 220Met Asn Pro Leu Pro Lys Pro Ser Val Asp Thr Gly Met Gly Leu Glu225 230 235 240Arg Ile Ala Ala Val Met Gln His Val His Ser Asn Tyr Glu Ile Asp245 250 255Leu Phe Gln Asp Leu Leu Lys Ala Val Ala Arg Glu Thr Gly Ala Pro260 265 270Phe Arg Met Glu Glu Pro Ser Leu Lys Val Ile Ala Asp His Ile Arg275 280 285Ser Cys Ser Phe Leu Ile Ala Asp Gly Val Leu Pro Ser Asn Glu Gly290 295 300Arg Gly Tyr Val Leu Arg Arg Ile Ile Arg Arg Ala Val Arg His Gly305 310 315 320Tyr Lys Leu Gly Gln Ser Lys Pro Phe Phe His Lys Leu Val Ala Asp325 330 335Leu Val Lys Glu Met Gly Gly Ala Tyr Pro Glu Leu Lys Glu Lys Gln340 345 350
Ala Gln Ile Glu Glu Ala Leu Lys Asn Glu Glu Ser Arg Phe Ala Gln355 360 365Thr Leu Glu Thr Gly Met Ala Leu Leu Glu Asn Ala Leu Val Lys Gly370 375 380Gly Lys Thr Leu Gly Gly Glu Ile Ile Phe Lys Leu Tyr Asp Thr Tyr385 390 395 400Gly Phe Pro Tyr Asp Leu Thr Ala Asp Ile Cys Arg Glu Arg Asn Ile405 410 415Glu Pro Asp Glu Ala Gly Phe Glu Arg Glu Met Glu Ala Gln Arg Ala420 425 430Arg Ala Arg Ala Ala Gln Ser Phe Lys Ala Asn Ala Gln Leu Pro Tyr435 440 445Asp Gly Gln Asp Thr Glu Phe Lys Gly Tyr Ser Glu Arg Gln Thr Glu450 455 460Ser Lys Val Leu Ala Leu Tyr Lys Asp Gly Glu Gln Val Asn Glu Leu465 470 475 480Asn Glu Gly Asp Ser Gly Ala Val Val Ile Asp Phe Thr Pro Phe Tyr485 490 495Ala Glu Ser Gly Gly Gln Val Gly Asp Val Gly Tyr Ile Phe Ser Gly500 505 510Glu Asn Arg Phe Glu Val Arg Asp Thr Gln Lys Ile Lys Ala Ala Val515 520 525Phe Gly Gln Phe Gly Val Gln Thr Ser Gly Arg Leu Lys Val Gly Asp530 535 540Ser Val Thr Ala Lys Val Asp Asp Glu Ile Arg Asn Ala Asn Met Arg545 550 555 560Asn His Ser Ala Thr His Leu Met His Lys Ala Leu Arg Asp Val Leu565 570 575Gly Arg His Val Glu Gln Lys Gly Ser Leu Val Thr Ala Glu Ser Thr580 585 590Arg Phe Asp Ile Ser His Pro Gln Ala Val Thr Ala Glu Glu Ile Ala595 600 605
Glu Val Glu Arg Arg Val Asn Glu Ala Ile Leu Ala Asn Val Ala Val610 615 620Asn Ala Ala Ile Met Ser Met Glu Asp Ala Gln Lys Thr Gly Ala Met625 630 635 640Met Leu Phe Gly Glu Lys Tyr Gly Glu Glu Val Arg Val Leu Gln Met645 650 655Gly Gly Phe Ser Thr Glu Leu Cys Gly Gly Thr His Val Ser Arg Thr660 665 670Gly Asp Ile Gly Leu Phe Lys Ile Ile Ser Glu Gly Gly Ile Ala Ala675 680 685Gly Val Arg Arg Ile Glu Ala Ile Thr Gly Leu Asn Ala Leu Lys Trp690 695 700Ala Gln Glu Gln Glu Arg Leu Val Lys Asp Ile Ile Ala Glu Thr Lys705 710 715 720Ala Gln Thr Glu Lys Asp Val Leu Ala Lys Ile Gln Ala Gly Ala Ala725 730 735His Ala Lys Ala Leu Glu Lys Glu Leu Ala Arg Ala Lys Ala Glu Leu740 745 750Ala Val His Ala Gly Ala Lys Leu Leu Asp Asp Ala Lys Asp Leu Gly755 760 765Ala Ala Lys Leu Val Ala Ala Gln Ile Glu Ala Asp Ala Ala Ala Leu770 775 780Arg Glu Ile Val Thr Asp Leu Thr Gly Lys Ser Asp Asn Ala Val Ile785 790 795 800Leu Leu Ala Ala Val Asn Asp Gly Lys Val Ser Leu Cys Ala Gly Val805 810 815Ser Lys Pro Leu Thr Gly Lys Val Lys Ala Gly Asp Leu Val Lys Phe820 825 830Ala Ala Glu Gln Val Gly Gly Lys Gly Gly Gly Arg Pro Asp Leu Ala835 840 845Gln Ala Gly Gly Thr Asp Ala Asp Lys Leu Pro Ala Val Leu Asp Ser850 855 860
Val Lys Asp Trp Val Gly Ala Lys Leu Val865 870<210>199<211>207<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(207)<400>199gtg caa aga ggc cgt ctg aaa ggt ctc gtt tgc cgt agg ttg ggt cgc 48Val Gln Arg Gly Arg Leu Lys Gly Leu Val Cys Arg Arg Leu Gly Arg1 5 10 15gac cca aca aat ttt gtg aag tat aaa aat gtt ggt cat gac cca acc 96Asp Pro Thr Asn Phe Val Lys Tyr Lys Asn Val Gly His Asp Pro Thr20 25 30tac ctg cct ttt tgt aca aag agg cta tct gaa agg cct tgt ttg ccg 144Tyr Leu Pro Phe Cys Thr Lys Arg Leu Ser Glu Arg Pro Cys Leu Pro35 40 45tat ggt ggg tcg cga ccc agc aga ttt tta tta ggg tat gac cca agc 192Tyr Gly Gly Set Arg Pro Ser Arg Phe Leu Leu Gly Tyr Asp Pro Set50 55 60tac ttg cta cga taa 207Tyr Leu Leu Arg65<210>200<211>68<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>200Val Gln Arg Gly Arg Leu Lys Gly Leu Val Cys Arg Arg Leu Gly Arg1 5 10 15Asp Pro Thr Asn Phe Val Lys Tyr Lys Asn Val Gly His Asp Pro Thr20 25 30
Tyr Leu Pro Phe Cys Thr Lys Arg Leu Ser Glu Arg Pro Cys Leu Pro35 40 45Tyr Gly Gly Ser Arg Pro Ser Arg Phe Leu Leu Gly Tyr Asp Pro Ser50 55 60Tyr Leu Leu Arg65<210>201<211>2277<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(2277)<400>201atg gca caa act aca ctc aaa ccc att gtt tta tca att ctt tta atc48Met Ala Gln Thr Thr Leu Lys Pro Ile Val Leu Ser Ile Leu Leu Ile1 5 10 15aac aca ccc ctc ctc gcc caa gcg cat gaa act gag caa tcg gtg gat96Asn Thr Pro Leu Leu Ala Gln Ala His Glu Thr Glu Gln Ser Val Asp20 25 30ttg gaa acg gtc agc gtc gtc ggc aaa agc cgt ccg cgc gcc acg tcg144Leu Glu Thr Val Ser Val Val Gly Lys Ser Arg Pro Arg Ala Thr Ser35 40 45ggg ctg ttg cac act tcg acc gcc tcc gac aaa atc atc tcc ggc gat192Gly Leu Leu His Thr Ser Thr Ala Ser Asp Lys Ile Ile Ser Gly Asp50 55 60acc ttg cgc caa aaa gcc gtc aac ttg ggc gac gct tta gac ggc gta240Thr Leu Arg Gln Lys Ala Val Asn Leu Gly Asp Ala Leu Asp Gly Val65 70 75 80ccg ggc atc cac gct tcg caa tac ggc ggc ggc gcg tct gct ccc gtc288Pro Gly Ile His Ala Ser Gln Tyr Gly Gly Gly Ala Ser Ala Pro Val85 90 95att cgc ggt caa aca ggc agg cgg att aaa gtg ttg aac cat cac ggc336Ile Arg Gly Gln Thr Gly Arg Arg Ile Lys Val Leu Asn His His Gly100 105 110
gaa aca ggc gat atg gcg gat ttt tcg ccc gat cac gcc att atg gta384Glu Thr Gly Asp Met Ala Asp Phe Ser Pro Asp His Ala Ile Met Val115 120 125gat acc gcc ttg tcg caa cag gtc gaa atc ctg cgc ggg ccg gtt acg432Asp Thr Ala Leu Ser Gln Gln Val Glu Ile Leu Arg Gly Pro Val Thr130 135 140ctc ttg tac agc tcg ggc aat gtg gcg ggg ctg gtc gat gtt gcc gat480Leu Leu Tyr Ser Ser Gly Asn Val Ala Gly Leu Val Asp Val Ala Asp145 150 155 160ggc aaa atc ccc gaa aaa atg cct gaa aac ggc gta tcg ggc gaa ctc528Gly Lys Ile Pro Glu Lys Met Pro Glu Asn Gly Val Ser Gly Glu Leu165 170 175gga ttg cgt ttg agc agc ggc aat ctg gaa aaa ctc acg tcc ggc ggc576Gly Leu Arg Leu Ser Ser Gly Asn Leu Glu Lys Leu Thr Ser Gly Gly180 185 190atc aat atc ggt ttg ggc aaa aac ttt gta ttg cac acg gaa ggg ctg624Ile Asn Ile Gly Leu Gly Lys Asn Phe Val Leu His Thr Glu Gly Leu195 200 205tac cgc aaa tcg ggg gat tac gcc gta ccg cgt tac cgc aat ctg aaa672Tyr Arg Lys Ser Gly Asp Tyr Ala Val Pro Arg Tyr Arg Asn Leu Lys210 215 220cgc ctg ccc gac agc cac gcc gat tcg caa acg ggc agc atc ggg ctg720Arg Leu Pro Asp Ser His Ala Asp Ser Gln Thr Gly Ser Ile Gly Leu225 230 235 240tct tgg gtt ggc gaa aaa ggt ttt atc ggc gta gcg tac agc gac cgt768Ser Trp Val Gly Glu Lys Gly Phe Ile Gly Val Ala Tyr Ser Asp Arg245 250 255cgc gac caa tat ggt ctg cct gcc cac agc cac gaa tac gat gat tgc816Arg Asp Gln Tyr Gly Leu Pro Ala His Ser His Glu Tyr Asp Asp Cys260 265 270cac gcc gac atc atc tgg caa aag agc ttg att aac aaa cgc tat tta864His Ala Asp Ile Ile Trp Gln Lys Ser Leu Ile Asn Lys Arg Tyr Leu275 280 285cag ctt tat ccg cac ctg ttg acc gaa gaa gac atc gat tac gac aat912Gln Leu Tyr Pro His Leu Leu Thr Glu Glu Asp Ile Asp Tyr Asp Asn290 295 300
ccg ggc ttg agc tgc ggc ttc cac gac gac gat aat gca cac gca cac960Pro Gly Leu Ser Cys Gly Phe His Asp Asp Asp Asn Ala His Ala His305 310 315 320acc cac agc ggc aga ccg tgg ata gac ctg cgc aac aaa cgc tac gaa1008Thr His Ser Gly Arg Pro Trp Ile Asp Leu Arg Asn Lys Arg Tyr Glu325 330 335ctc cgt gcc gaa tgg aag caa ccg ttc ccc ggt ttt gaa gcc ctg cgc1056Leu Arg Ala Glu Trp Lys Gln Pro Phe Pro Gly Phe Glu Ala Leu Arg340 345 350gta cac ctg aac cgc aac gac tac cgc cac gac gaa aaa gca ggc gat1104Val His Leu Asn Arg Asn Asp Tyr Arg His Asp Glu Lys Ala Gly Asp355 360 365gca gtc gaa aac ttt ttt aac aac caa acg caa aac gco cgc atc gag1152Ala Val Glu Asn Phe Phe Asn Asn Gln Thr Gln Asn Ala Arg Ile Glu370 375 380ttg cgc cac caa ccc ata ggt cgt ctg aaa ggc agc tgg ggc gtg caa1200Leu Arg His Gln Pro Ile Gly Arg Leu Lys Gly Ser Trp Gly Val Gln385 390 395 400tat tta caa caa aaa tcc agt gct tta tct gcc ata tcc gaa gcg gtt1248Tyr Leu Gln Gln Lys Ser Ser Ala Leu Ser Ala Ile Ser Glu Ala Val405 410 415aaa caa ccg atg ctg ctt gac aac aaa gtg caa cat tac agc ttt ttc1296Lys Gln Pro Met Leu Leu Asp Asn Lys Val Gln His Tyr Ser Phe Phe420 425 430ggt gta gaa cag gca aac tgg gac aac ttc acg ctt gaa gga ggc gta1344Gly Val Glu Gln Ala Asn Trp Asp Asn Phe Thr Leu Glu Gly Gly Val435 440 445cgc gtg gaa aaa caa aaa gcc tcc att cag tac gac aaa gca ttg att1392Arg Val Glu Lys Gln Lys Ala Ser Ile Gln Tyr Asp Lys Ala Leu Ile450 455 460gat cgg gaa aac tac tac aac cac ccc ctg ccc gac ctc ggc gcg cac1440Asp Arg Glu Asn Tyr Tyr Asn His Pro Leu Pro Asp Leu Gly Ala His465 470 475 480cgc caa acc gcc cgc tca ttc gca ctt tcg ggc aac tgg tat ttc acg1488Arg Gln Thr Ala Arg Ser Phe Ala Leu Ser Gly Asn Trp Tyr Phe Thr485 490 495
cca caa cac aaa ctc agc ctg acc gcc tcc cat cag gaa cgc ctg ccg1536Pro Gln His Lys Leu Ser Leu Thr Ala Ser His Gln Glu Arg Leu Pro500 505 510tca acg caa gag ctg tac gca cac ggc aaa cac gtc gcc acc aac acc1584Ser Thr Gln Glu Leu Tyr Ala His Gly Lys His Val Ala Thr Asn Thr515 520 525ttt gaa gtc ggc aac aaa cac ctc aac aaa gag cgt tcc aac aat atc1632Phe Glu Val Gly Asn Lys His Leu Asn Lys Glu Arg Ser Asn Asn Ile530 535 540gaa ctc gcg ctg ggc tac gaa ggc gac cgc tgg caa tac aat ctg gca1680Glu Leu Ala Leu Gly Tyr Glu Gly Asp Arg Trp Gln Tyr Asn Leu Ala545 550 555 560ctc tac cgc aac cgc ttc ggt aac tac att tac gGc caa acc tta aac1728Leu Tyr Arg Asn Arg Phe Gly Asn Tyr Ile Tyr Ala Gln Thr Leu Asn565 570 575gac gga cgc ggc ccc aaa tcc atc gaa gac gac agc gaa atg aag ctc1776Asp Gly Arg Gly Pro Lys Ser Ile Glu Asp Asp Ser Glu Met Lys Leu580 585 590gtg cgc tac aac caa tcc ggc gcc gac ttc tac ggc gcg gaa ggc gaa1824Val Arg Tyr Asn Gln Ser Gly Ala Asp Phe Tyr Gly Ala Glu Gly Glu595 600 605atc tac ttc aaa ccg aca ccg cgc tac cgc atc ggc gtt tcc ggc gac1872Ile Tyr Phe Lys Pro Thr Pro Arg Tyr Arg Ile Gly Val Ser Gly Asp610 615 620tat gta cga ggc cgt ctg aaa aac ctg cct tcc cta ccc ggc aga gaa1920Tyr Val Arg Gly Arg Leu Lys Asn Leu Pro Ser Leu Pro Gly Arg Glu625 630 635 640gat gcc tac ggc aac cgt cct ttc atc gca cag gac gac caa aat gcc1968Asp Ala Tyr Gly Asn Arg Pro Phe Ile Ala Gln Asp Asp Gln Asn Ala645 650 655ccc cgt gtt ccg gct gcg cgc ctc ggc ttc cac ctg aaa gcc tcg ctg2016Pro Arg Val Pro Ala Ala Arg Leu Gly Phe His Leu Lys Ala Ser Leu660 665 670acc gac cgt atc gat gcc aat ttg gac tac tac cgc gtg ttc gcc caa2064Thr Asp Arg Ile Asp Ala Asn Leu Asp Tyr Tyr Arg Val Phe Ala Gln675 680 685
aac aaa ctc gcc cgc tac gaa acg cgc acg ccc gga cac cat atg ctc2112Asn Lys Leu Ala Arg Tyr Glu Thr Arg Thr Pro Gly His His Met Leu690 695 700aac ctc ggc gca aac tac cgc cgc aat acg cgc tat ggc gag tgg aat2160Asn Leu Gly Ala Asn Tyr Arg Arg Asn Thr Arg Tyr Gly Glu Trp Asn705 710 715 720tgg tac gtc aaa gcc gac aac ctg ctc aac caa tcc gtt tac gcc cac2208Trp Tyr Val Lys Ala Asp Asn Leu Leu Asn Gln Ser Val Tyr Ala His725 730 735agc agc ttt ctc tct gat acg ccg caa atg ggc cgc agc ttt acc ggc2256Ser Ser Phe Leu Ser Asp Thr Pro Gln Met Gly Arg Ser Phe Thr Gly740 745 750ggc gtg aac gtg aag ttt taa2277Gly Val Asn Val Lys Phe755<210>202<211>758<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>202Met Ala Gln Thr Thr Leu Lys Pro Ile Val Leu Ser Ile Leu Leu Ile1 5 10 15Asn Thr Pro Leu Leu Ala Gln Ala His Glu Thr Glu Gln Ser Val Asp20 25 30Leu Glu Thr Val Ser Val Val Gly Lys Ser Arg Pro Arg Ala Thr Ser35 40 45Gly Leu Leu His Thr Ser Thr Ala Ser Asp Lys Ile Ile Ser Gly Asp50 55 60Thr Leu Arg Gln Lys Ala Val Asn Leu Gly Asp Ala Leu Asp Gly Val65 70 75 80Pro Gly Ile His Ala Ser Gln Tyr Gly Gly Gly Ala Ser Ala Pro Val85 90 95Ile Arg Gly Gln Thr Gly Arg Arg Ile Lys Val Leu Asn His His Gly100 105 110
Glu Thr Gly Asp Met Ala Asp Phe Ser Pro Asp His Ala Ile Met Val115 120 125Asp Thr Ala Leu Ser Gln Gln Val Glu Ile Leu Arg Gly Pro Val Thr130 135 140Leu Leu Tyr Ser Ser Gly Asn Val Ala Gly Leu Val Asp Val Ala Asp145 150 155 160Gly Lys Ile Pro Glu Lys Met Pro Glu Asn Gly Val Ser Gly Glu Leu165 170 175Gly Leu Arg Leu Ser Ser Gly Asn Leu Glu Lys Leu Thr Ser Gly Gly180 185 190Ile Asn Ile Gly Leu Gly Lys Asn Phe Val Leu His Thr Glu Gly Leu195 200 205Tyr Arg Lys Ser Gly Asp Tyr Ala Val Pro Arg Tyr Arg Asn Leu Lys210 215 220Arg Leu Pro Asp Ser His Ala Asp Ser Gln Thr Gly Ser Ile Gly Leu225 230 235 240Ser Trp Val Gly Glu Lys Gly Phe Ile Gly Val Ala Tyr Ser Asp Arg245 250 255Arg Asp Gln Tyr Gly Leu Pro Ala His Ser His Glu Tyr Asp Asp Cys260 265 270His Ala Asp Ile Ile Trp Gln Lys Ser Leu Ile Asn Lys Arg Tyr Leu275 280 285Gln Leu Tyr Pro His Leu Leu Thr Glu Glu Asp Ile Asp Tyr Asp Asn290 295 300Pro Gly Leu Ser Cys Gly Phe His Asp Asp Asp Asn Ala His Ala His305 310 315 320Thr His Ser Gly Arg Pro Trp Ile Asp Leu Arg Asn Lys Arg Tyr Glu325 330 335Leu Arg Ala Glu Trp Lys Gln Pro Phe Pro Gly Phe Glu Ala Leu Arg340 345 350Val His Leu Asn Arg Asn Asp Tyr Arg His Asp Glu Lys Ala Gly Asp355 360 365
Ala Val Glu Asn Phe Phe Asn Asn Gln Thr Gln Asn Ala Arg Ile Glu370 375 380Leu Arg His Gln Pro Ile Gly Arg Leu Lys Gly Ser Trp Gly Val Gln385 390 395 400Tyr Leu Gln Gln Lys Ser Ser Ala Leu Ser Ala Ile Ser Glu Ala Val405 410 415Lys Gln Pro Met Leu Leu Asp Asn Lys Val Gln His Tyr Ser Phe Phe420 425 430Gly Val Glu Gln Ala Asn Trp Asp Asn Phe Thr Leu Glu Gly Gly Val435 440 445Arg Val Glu Lys Gln Lys Ala Ser Ile Gln Tyr Asp Lys Ala Leu Ile450 455 460Asp Arg Glu Asn Tyr Tyr Asn His Pro Leu Pro Asp Leu Gly Ala His465 470 475 480Arg Gln Thr Ala Arg Ser Phe Ala Leu Ser Gly Asn Trp Tyr Phe Thr485 490 495Pro Gln His Lys Leu Ser Leu Thr Ala Ser His Gln Glu Arg Leu Pro500 505 510Ser Thr Gln Glu Leu Tyr Ala His Gly Lys His Val Ala Thr Asn Thr515 520 525Phe Glu Val Gly Asn Lys His Leu Asn Lys Glu Arg Ser Asn Asn Ile530 535 540Glu Leu Ala Leu Gly Tyr Glu Gly Asp Arg Trp Gln Tyr Asn Leu Ala545 550 555 560Leu Tyr Arg Asn Arg Phe Gly Asn Tyr Ile Tyr Ala Gln Thr Leu Asn565 570 575Asp Gly Arg Gly Pro Lys Ser Ile Glu Asp Asp Ser Glu Met Lys Leu580 585 590Val Arg Tyr Asn Gln Ser Gly Ala Asp Phe Tyr Gly Ala Glu Gly Glu595 600 605Ile Tyr Phe Lys Pro Thr Pro Arg Tyr Arg Ile Gly Val Ser Gly Asp610 615 620
Tyr Val Arg Gly Arg Leu Lys Asn Leu Pro Ser Leu Pro Gly Arg Glu625 630 635 640Asp Ala Tyr Gly Asn Arg Pro Phe Ile Ala Gln Asp Asp Gln Asn Ala645 650 655Pro Arg Val Pro Ala Ala Arg Leu Gly Phe His Leu Lys Ala Ser Leu660 665 670Thr Asp Arg Ile Asp Ala Asn Leu Asp Tyr Tyr Arg Val Phe Ala Gln675 680 685Asn Lys Leu Ala Arg Tyr Glu Thr Arg Thr Pro Gly His His Met Leu690 695 700Asn Leu Gly Ala Asn Tyr Arg Arg Asn Thr Arg Tyr Gly Glu Trp Asn705 710 715 720Trp Tyr Val Lys Ala Asp Asn Leu Leu Asn Gln Ser Val Tyr Ala His725 730 735Ser Ser Phe Leu Ser Asp Thr Pro Gln Met Gly Arg Ser Phe Thr Gly740 745 750Gly Val Asn Val Lys Phe755<210>203<211>225<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(225)<400>203atg agg ctg gca acc aag gat ttg gcg gaa gcc att agg aaa gga cag48Met Arg Leu Ala Thr Lys Asp Leu Ala Glu Ala Ile Arg Lys Gly Gln1 5 10 15gtt cgc aaa tca agc ttt aac aca gaa caa tta agg gca att gaa aaa96Val Arg Lys Ser Ser Phe Asn Thr Glu Gln Leu Arg Ala Ile Glu Lys20 25 30
gga gaa tct aaa ata ccg gat tac act tgg cat cat cat caa gat aca144Gly Glu Ser Lys Ile Pro Asp Tyr Thr Trp His His His Gln Asp Thr35 40 45gga agg atg caa ttg att cgt gaa ggc ttg cat cat gat acc ggc cat192Gly Arg Met Gln Leu Ile Arg Glu Gly Leu His His Asp Thr Gly His50 55 60att ggt tgg gaa gca atg aac aaa gga agg taa225Ile Gly Trp Glu Ala Met Asn Lys Gly Arg65 70 75<210>204<211>74<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>204Met Arg Leu Ala Thr Lys Asp Leu Ala Glu Ala Ile Arg Lys Gly Gln1 5 10 15Val Arg Lys Ser Ser Phe Asn Thr Glu Gln Leu Arg Ala Ile Glu Lys20 25 30Gly Glu Ser Lys Ile Pro Asp Tyr Thr Trp His His His Gln Asp Thr35 40 45Gly Arg Met Gln Leu Ile Arg Glu Gly Leu His His Asp Thr Gly His50 55 60Ile Gly Trp Glu Ala Met Asn Lys Gly Arg65 70<210>205<211>1176<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(1176)<400>205atg gca aaa atg atg aaa tgg gcg gct gtt gcg gcg gtc gcg gcg gca48Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala
1 5 10 15gcg gtt tgg ggc gga tgg tct tat ctg aag ccc gag ccg cag gct gct96Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala20 25 30tat att acg gaa acg gtc agg cgc ggc gac atc agc cgg acg gtt tct144Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser35 40 45gca aca ggg gag att tcg ccg tcc aac ctg gta tcg gtc ggc gcg cag192Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln50 55 60gca tcg ggg cag att aag aaa ctt tat gtc aaa ctc ggg caa cag gtt240Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val65 70 75 80aaa aag ggc gat ttg att gcg gaa atc aat tcg acc tcg cag acc aat288Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn85 90 95acg ctc aat acg gaa aaa tcc aaa ttg gaa acg tat cag gcg aag ctg336Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu100 105 110gtg tcg gca cag att gca ttg ggc agc gcg gag aag aaa tat aag cgt384Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg115 120 125cag gcg gcg ttg tgg aag gat gat gcg acc gct aaa gaa gat ttg gaa432Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu130 135 140agc gca cag gat gcg ctt gcc gcc gcc aaa gcc aat gtt gcc gag ctg480Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu145 150 155 160aag gct cta atc aga cag agc aaa att tcc atc aat acc gcc gag tcg528Lys Ala Leu Ile Arg Gln Ser Lys Ile Ser Ile Asn Thr Ala Glu Ser165 170 175gaa ttg ggc tac acg cgc att acc gca acg atg gac ggc acg gtg gtg576Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val180 185 190gcg att ctc gtg gaa gag ggg cag act gtg aac gcg gcg cag tct acg624Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr
195 200 205ccg acg att gtc caa ttg gcg aat ctg gat atg atg ttg aac aaa atg672Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met210 215 220cag att gcc gag ggc gat att acc aag gtg aag gcg ggg cag gat att720Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile225 230 235 240tcg ttt acg att ttg tcc gaa ccg gat acg ccg att aag gcg aag ctc768Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu245 250 255gac agc gtc gac ccc ggg ctg acc acg atg tcg tcg ggc ggc tac aac816Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn260 265 270agc agt acg gat acg gct tcc aat gcg gtc tac tat tat gcc cgt tcg864Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser275 280 285ttt gtg ccg aat ccg gac ggc aaa ctc gcc acg ggg atg acg acg cag912Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln290 295 300aat acg gtt gaa atc gac ggt gtg aaa aat gtg ctg att att ccg tcg960Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser305 310 315 320ctg acc gtg aaa aat cgc ggc ggc agg gcg ttt gtg cgc gtg ttg ggt1008Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arg Val Leu Gly325 330 335gca gac ggc aag gcg gcg gaa cgc gaa atc cgg acc ggt atg aga gac1056Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp340 345 350agt atg aat acc gaa gta aaa agc ggg ttg aaa gag ggg gac aaa gtg1104Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val355 360 365gtc atc tcc gaa ata acc gcc gcc gag cag cag gaa agc ggc gaa cgc1152Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg370 375 380gcc cta ggc ggc ccg ccg cgc cga1176Ala Leu Gly Gly Pro Pro Arg Arg
385 390<210>206<211>392<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>206Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala1 5 10 15Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala20 25 30Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser35 40 45Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln50 55 60Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val65 70 75 80Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn85 90 95Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu100 105 110Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg115 120 125Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu130 135 140Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu145 150 155 160Lys Ala Leu Ile Arg Gln Ser Lys Ile Ser Ile Asn Thr Ala Glu Ser165 170 175Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val180 185 190Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr195 200 205
Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met210 215 220Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile225 230 235 240Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu245 250 255Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn260 265 270Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser275 280 285Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln290 295 300Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser305 310 315 320Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arp Val Leu Gly325 330 335Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp340 345 350Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val355 360 365Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg370 375 380Ala Leu Gly Gly Pro Pro Arg Arg385 390<210>207<211>342<212>DNA<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<220>
<221>CDS<222>(1)..(342)<400>207
ttg ttt gta tgc ttt gaa aaa tgt ttg ttt ccg gat ttt gcc att ccc48Leu Phe Val Cys Phe Glu Lys Cys Leu Phe Pro Asp Phe Ala Ile Pro1 5 10 15atc cgg ttt tgc gct gta cga tgt gtt tta gcg cgg act tgc tca aaa96Ile Arg Phe Cys Ala Val Arg Cys Val Leu Ala Arg Thr Cys Ser Lys20 25 30tcg gat gtg gtt ccg gta ttt ggg gct ttg att agg gat gcg gac ttt144Ser Asp Val Val Pro Val Phe Gly Ala Leu Ile Arg Asp Ala Asp Phe35 40 45caa tat att ttt ctc agc tac aac aac gaa ggc ttg atg tct gtc ggg192Gln Tyr Ile Phe Leu Ser Tyr Asn Asn Glu Gly Leu Met Ser Val Gly50 55 60cag gta agg gag att ttt gag cgt ttc ggc aaa tat aat ttg gtt caa240Gln Val Arg Glu Ile Phe Glu Arg Phe Gly Lys Tyr Asn Leu Val Gln65 70 75 80acg gaa tat cgg cgt ttt aag gca gat aag aca gaa aac cgt aat cat288Thr Glu Tyr Arg Arg Phe Lys Ala Asp Lys Thr Glu Asn Arg Asn His85 90 95aag gca aat tcg ata ttc gaa tat ctg cat gag acc ttt gca aaa ata336Lys Ala Asn Ser Ile Phe Glu Tyr Leu His Glu Thr Phe Ala Lys Ile100 105 110gtc tgt342Val Cys<210>208<211>114<212>PRT<213>脑膜炎奈瑟氏球菌(Neisseria meningitidis)<400>208Leu Phe Val Cys Phe Glu Lys Cys Leu Phe Pro Asp Phe Ala Ile Pro1 5 10 15Ile Arg Phe Cys Ala Val Arg Cys Val Leu Ala Arg Thr Cys Ser Lys20 25 30Ser Asp Val Val Pro Val Phe Gly Ala Leu Ile Arg Asp Ala Asp Phe35 40 45Gln Tyr Ile Phe Leu Ser Tyr Asn Asn Glu Gly Leu Met Ser Val Gly
50 55 60Gln Val Arg Glu Ile Phe Glu Arg Phe Gly Lys Tyr Asn Leu Val Gln65 70 75 80Thr Glu Tyr Arg Arg Phe Lys Ala Asp Lys Thr Glu Asn Arg Asn His85 90 95Lys Ala Asn Ser Ile Phe Glu Tyr Leu His Glu Thr Phe Ala Lys Ile100 105 110Val Cys<210>209<211>24<212>DNA<213>人工序列<220>
<223>人工序列说明引物序列<400>209ttggttaatt ggttgtaaca ctgg24<210>210<211>19<212>DNA<213>人工序列<220>
<223>人工序列说明引物序列<400>210attctcatgt ttgacagcg 19<210>211<211>18<212>DNA<213>人工序列<220>
<223>人工序列说明引物序列
<400>211atcctacaac ctcaagct18<210>212<211>18<212>DNA<213>人工序列<220>
<223>人工序列说明引物序列<400>212atcccattct aaccaagc18<210>213<211>19<212>DNA<213>人工序列<220>
<223>人工序列说明引物序列<400>213aagagattac gcgcagacc 19<210>214<211>18<212>DNA<213>人工序列<220>
<223>人工序列说明引物序列<400>214aatacgcaac cgcctctc 18
权利要求
1.用于治疗或诊断应用的肽，由操纵子编码，所述操纵子包括在此鉴定的如SEQ ID NO.3，5，7，9，11，13，15，17，19，21，23，25，27，29，31，33，37，39，41，43，45，47，49，51，53，55，57，59，61，63，65，67，69，71，73，75，77，79，81，83，85，87，89，91，93，95，97，99，101，103，105，107，109，111，113，115，117，119，121，123，125，127，129，131，133，135，137，139，141，143，145，147，149，151，153，155，157，159，161，163，165，167，169，171，173，175，177，179，181，183，185，187，189，191，193，195，197，199，201，203，205，207所示的脑膜炎奈瑟氏球菌的任何核苷酸序列，或革兰氏阴性细菌中在肽或核苷酸水平具有至少60％序列相似性或同一性的相关分子，或其功能片段。
2.根据权利要求1的肽，其中序列相似性或同一性为至少90％。
3.根据权利要求1的肽，其包含在此鉴定的如SEQ IDNO.4，6，8，10，12，14，16，18，20，22，24，26，28，30，32，34，38，40，42，44，46，48，50，52，54，56，58，60，62，64，66，68，70，72，74，76，78，80，82，84，86，88，90，92，94，96，98，100，102，104，106，108，110，112，114，116，118，120，122，124，126，128，130，132，134，136，138，140，142，144，146，148，150，152，154，156，158，160，162，164，166，168，170，172，174，176，178，180，182，184，186，188，190，192，194，196，198，200，202，204，206和208所示的氨基酸序列。
4.编码任何一项前述权利要求的肽的多核苷酸，用于治疗或诊断应用。
5.经转化表达权利要求1-3中任一项的肽的宿主。
6.减毒微生物，其包含破坏下列核苷酸序列的表达的突变如SEQ II NO.1定义的核苷酸序列，或权利要求1中定义的任何核苷酸序列，除外如SEQ ID NO.89和157定义的核苷酸序列。
7.根据权利要求6的微生物，其中所述突变是插入失活或基因缺失。
8.根据权利要求6或7的微生物，其中所述微生物是脑膜炎奈瑟氏球菌。
9.根据权利要求6-8中任一项的微生物，其包含在第二条核苷酸序列中的第二个突变。
10.根据权利要求6-9中任一项的微生物，用于治疗或诊断应用。
11.根据权利要求6-10中任一项的微生物，其包含异源性抗原、治疗性肽或核酸。
12.疫苗，其包含权利要求1-3中任一项的肽，或其表达工具。
13.疫苗，其包含权利要求6-11中任一项的微生物。
14.针对权利要求1-3中任一项的肽产生的抗体。
15.权利要求1-11中任一项的产物在制备用于治疗或预防与奈瑟氏球菌属或革兰氏阴性细菌感染有关的病症的药物中的用途。
16.根据权利要求15的用途，其中所述病症是脑膜炎。
17.根据权利要求15或16的用途，用于兽医治疗。
18.权利要求1-11中任一项的产物在鉴定抗微生物药物的筛选试验中的用途。
全文摘要
本发明显示了一系列来自脑膜炎奈瑟氏球菌的基因编码的产物涉及毒力。因此鉴定这些基因可以产生减毒微生物。此外，所述基因或其编码产物可用于制备治疗用的疫苗。
文档编号C07K14/195GK1840665SQ200510136290
公开日2006年10月4日 申请日期2001年5月8日 优先权日2000年5月8日
发明者C·唐 申请人:微科学有限公司