γ-catenin基因,γ-catenin gene
1)γ-catenin geneγ-catenin基因
1.Effect of 5-Aza-2’-deoxycytidine on growth inhibition of renal carcinoma cell line OS-RC-2 and reversion of γ-catenin gene hypermethylation5-氮杂-2’-脱氧胞苷抑制肾癌细胞增殖及逆转γ-catenin基因甲基化作用
2.Objective:To investigate the influence of 5-Aza-2\'-deoxycytidine (5-Aza-CdR) on the proliferation and apoptosis of human renal carcinoma cell line OS-RC-2,and to study the influence of 5-Aza-CdR on methylati on ofγ-catenin gene,so as to provide insights into origin of renal carcinoma and the possibility of its application in clinical treatment.目的:研究5-氮杂-2′-脱氧胞苷(5-Aza-CdR)对人肾癌OS-RC-2细胞株增殖、凋亡的影响,进一步分析5-Aza-CdR处理对γ-catenin基因甲基化状态的影响,初步探讨肾癌发病机制及临床治疗的可行性。
3.The methylation status of γ-catenin gene promoter region was reversed with 5-Aza-CdR 10-5mol/L treating for 72h.以甲基化特异性PCR(MSP)检测细胞处理前后γ-catenin基因的甲基化状态。
英文短句/例句

1.Effect of 5-Aza-2’-deoxycytidine on growth inhibition of renal carcinoma cell line OS-RC-2 and reversion of γ-catenin gene hypermethylation5-氮杂-2’-脱氧胞苷抑制肾癌细胞增殖及逆转γ-catenin基因甲基化作用
2.RNAi Specifically Inhibits the Expression of β-catenin Gene in Gastric Carcinoma Cells;RNAi特异性抑制胃癌细胞β-catenin基因表达的研究
3.Construction and identification of shRNA eukaryotic vector targeting human β-catenin针对人β-catenin基因shRNA真核表达载体的构建与鉴定
4.Ablation of p120-Catenin Altering the Activity of Small GTPase in Human Lung Cancer Cells肺癌细胞系中p120-catenin的基因缺失调控small GTP酶活性
5.Cloning and Bioinformatics Analysis of cDNA of β-catenin Gene in Peking Duck北京鸭β-catenin基因cDNA的克隆和生物信息学分析
6.The Role of Methylation in Runx_3 and Expressions of TGF-β1/β-catenin in Oncogenesis of Colonic CarcinomaRunx3基因甲基化及TGF-β1、β-catenin在结肠癌发生中的作用
7.Expression of the γ-catenin and CD44V6 and its Significance in the Primary Hepatocellular Carcinomaγ-catenin与CD44V6表达对原发性肝细胞肝癌的临床意义
8.Negative Regulation of β-catenin Signal Pathway by Pancreas Duodenum Homeobox-1;胰、十二指肠同源盒基因-1对β-catenin信号通路的调节机制研究
9.Studies on β-Catenin Mutation and Aberrant Expression in Sporadic Colorectal Cancers and Raman Spectra of Single Optically Trapped Sporadic Colorectal Cancer Cells;散发性结直肠癌的β-Catenin基因突变及表达和单细胞拉曼光谱研究
10.Study the Significance for Cell Apoptosis and β-catenin Gene Effected on Craniopharyngioma in Aetiology and Prognosis;细胞凋亡及β-catenin基因在颅咽管瘤发病及预后中的意义探讨
11.A Clinicopathologic Study of Cystic and Solid Tumors of Pancreas and the Analysis of β-catenin Mutation;胰腺囊性-实性肿瘤临床病理学及β-catenin基因突变研究
12.Expression of APC and β-catenin Gene and Their Clinical Significance in Human Sporadic Colorectal Carcinoma;散发性结直肠腺癌APC、β-catenin基因的表达及其临床意义
13.Studies on the Effects of NGX6 Gene in Wnt/Beta-catenin Signaling Pathway;NGX6基因在Wnt/Beta-catenin信号传导通路中的作用机制研究
14.The Peking Duck Embryo Follicle of Developmental Characteristics and β-Catenin Gene Cloning and Expression北京鸭胚胎期皮肤毛囊的发育特征及β-catenin基因的克隆与表达
15.Studying on the Relevance Between Aging Kidney-Yang Deficiency Syndrome and the Wnt/β-catenin Signaling Pathway by cDNA Microarray Assay运用基因芯片技术分析老龄肾阳虚证与Wnt/β-catenin信号通路的相关性
16.Detection of Beta-Catenin Protein Expression and Gene Mutation in Tumorigenesis of Endometrioid Adenocarcinoma子宫内膜样腺癌发生过程中β-catenin蛋白异常表达和基因突变的检测
17.Aberrant expression and mutation of β-catenin in sporadic colorectal cancerβ-Catenin蛋白在散发性结直肠癌中的异常表达和基因突变
18.Relationship between gene expression of β-catenin and embryonic neural tube defects induced by Retinoic acid维甲酸诱导胚胎神经管畸形与β-catenin基因表达的关系
相关短句/例句

β-catenin geneβ-catenin基因
1.Abnormalities of APC gene/β-catenin gene in Wnt pathway in desmoid-type fibromatosis;韧带样型纤维瘤病Wnt通路中APC/β-catenin基因异常
2.Objective To explore the relationship of the expression of β-catenin gene with pathological type of craniopharyngiomas and prognosis of the patients with craniopharyngiomas.目的探讨β-catenin基因和颅咽管瘤病理类型及预后的关系。
3.PurposeTo analyze the clinicopathologic features of desmoid-type fibromatosis, and to detect trisomy 8 and mutations of the APC gene and β-catenin gene in this tumor with a purpose of exploring the mechanism of the tumorigenesis and progression of this disease.运用免疫组织化学EnVision~+两步法检测69例存档石蜡包埋组织中β-catenin、cyclinD1、c-myc、Ki-67等蛋白的表达;用DNA末端转移酶介导的缺口标记法(Terminal Deoxynucleotidyl Transferase biotin-dUTP Nick End Labeling,TUNEL)检测病变中细胞凋亡;用聚合酶链反应(PCR)-变性液相高效质谱分析(Denaturing High Performance Liquid Chromatography,DHPLC)-直接测序的方法检测APC和β-catenin基因突变。
3)beta-catenin genebeta-catenin基因
4)γ-catenin expressionγ-catenin表达
1.Abnormal γ-catenin expression was found in 28/48(.方法:应用免疫组织化学方法(SP)对48例膀胱移行细胞癌和8例正常膀胱粘膜进行γ-catenin表达的研究。
5)γ-catenin proteinγ-catenin蛋白
6)γ-GCS geneγ-GCS基因
1.Study of RNAi γ-GCS gene in carcinoma of pancreas against chemiotherapy;γ-GCS基因的RNA干扰逆转胰腺癌抗化疗的实验研究
延伸阅读

β-catenin分子式:CAS号:性质:原癌基因编码的蛋白质,参与钙依黏附蛋白(cadehrin)胞内结构域介导的信号转导的重要分子。正常细胞内它的浓度较低。在由它介导信号转导的结果中都发现APC(adenomatous polyposis coli,是一种肿瘤抑制蛋白质),是一个β-连蛋白信号转导的负调节剂。显然β-连蛋白在恶性肿瘤病因研究领域中占有相当重要的地位。一旦APC或β连蛋白发生突变,即可发生信号转导减弱,细胞增殖加快与抑制细胞凋亡等作用,这是至今所了解的正常细胞发生恶变的β-连蛋白作用分子机制。