1)radiosensitizers硝基吲唑
1.Research on targeting radiosensitizers——nitroinzadole derivatesIn order to search for the new safe and effective radiosensitizers with high potency,Using 5-nitroindazole-3-carboxylic acid as a lead compound, and based on the principles of hybridization with amino acid,a series of 5-nitroindazole derivates were designed and synthesized.本研究根据氨基酸在肿瘤组织高吸收的特点,将硝基吲唑与氨基酸拼合,合成了6个NIES系列放射增敏剂,以增加硝基吲唑母核的水溶性,降低其神经毒性。
英文短句/例句
1.Effects and Mechanism of 7-nitroindazole on Smoke Inhalation Lung Injury in Rats;7-硝基吲唑对烟雾吸入性肺损伤大鼠的保护性作用及其机制
2.Protective Effect of 7-Nitroindazole on Neonatal Rat Models with Hypoxic-Ischemic Brain Damage;7-硝基吲唑在新生鼠缺氧缺血性脑损伤中的保护作用
3.Investigation of Protective Effects of 7-nitroindinazole on Brain in Rats Undergoing Deep Hypothermic Circulatory Arrest;7-硝基吲唑对深低温停循环大鼠的脑保护作用的研究
4.PREPARATION OF 4-NITROINDOLE-3-ACETIC ACID4-硝基-3-吲(口乃木)乙酸的制备
5.Determination of 2-Methyl-5-nitroimidazole in Metronidazole and its Injection by GC甲硝唑及注射液中2-甲基-5-硝基咪唑的GC测定
6.Synthesis of indolo[1,2-b] indazole derivatives via copper(Ⅰ)-catalyzed intramolecular amination reactionCu(Ⅰ)催化的分子内氨基化反应合成吲哚并[1,2-b]吲哒唑类化合物
7.Synthesis of 3,5-Dinitropyrazole in the Different Nitration System;不同硝化体系中3,5-二硝基吡唑的合成
8.Synthesis of 1,3,3,5-tetramethyl-6-nitro-indoline spiroben-zopyrans1,3,3,5-四甲基-6-硝基吲哚啉螺苯并吡喃的合成
9.Synthesis of 1-Methyl-4,5-dinitroimidazole1-甲基-4,5-二硝基咪唑合成工艺
10.Determination of 2-Methyl-5-Nitroimid Azole by Volhard Method佛尔哈德法测定2-甲基-5-硝基咪唑
11.Synthesis and Characterization of 1-Methyl-4,5-dinitroimidazole1-甲基-4,5-二硝基咪唑的合成及表征
12.Optimization of the Synthesis of 1-Methyl-2,4,5-trinitroimidazole1-甲基-2,4,5-三硝基咪唑合成工艺优化
13.New Technology for Synthesis of 1-Methyl-2,4,5-trinitroimidazoles1-甲基-2,4,5-三硝基咪唑的合成新工艺
14.Study on Metronidazole-loaded Carboxymethyl Chitosan Sustained-release Microspheres;甲硝唑羧甲基壳聚糖缓释微球的研究
15.Synthesis of 7-nitro-4(3H)-quinazolinone under microwave irradiation微波辐射合成7-硝基-4(3H)-喹唑啉酮
16.High-Quality Conducting Polymers Prepared from 3-Methylthiophene and Pyrrole, Indole, Carzole by Electrochemical Copolymerization;3-甲基噻吩与吡咯、吲哚、咔唑电化学共聚制备高性能导电高分子
17.Preparation of Azo Polymer Bearing Indazole Moiety via RAFT Polymerization and Investigation on Their Properties含吲唑基团偶氮苯聚合物的RAFT法合成及其性能研究
18.Effects of L-arg and 7-NI on the HRV in NA of Rats;疑核注射L-精氨酸和7-硝基吲哚对大鼠心率变异性的影响
相关短句/例句
7-nitroindazole7-硝基吲唑
1.Effects and Mechanism of 7-nitroindazole on Smoke Inhalation Lung Injury in Rats;7-硝基吲唑对烟雾吸入性肺损伤大鼠的保护性作用及其机制
2.7-nitroindazole,a selective inhibitor of nNOS,was given intraperi-(toneally.方法闭塞大鼠左侧大脑中动脉造成局灶性脑缺血模型,给予不同剂量选择性nNO S抑制剂7-硝基吲唑,用硝酸还原酶法检测脑组织-氧化氮(NO)水平,流式细胞术检测硝基酪氨酸(NT)表达,RT-PCR法检测B cl-2表达的变化,并与溶剂对照组进行比较。
3.Methods Using rat model of focal severe cortical contusions according to Feeney,NO content and NOS activity in ipsilateral cortex,and the effect of nNOS inhibitor 7-nitroindazole(7-NI) on them were observed.方法采用落体法大鼠TBI动物模型,观察大鼠TBI早期脑组织NO含量、NOS活性的动态变化和特异性nNOS抑制剂7-硝基吲唑(7-NI)对其的影响。
3)7-NItroindazole(7-NI)7-硝基-吲唑
1.And to evaluate the effect of selective nitric oxide synthase inhibitor-7-NItroindazole(7-NI) on apoptosis of neurons after HIBD in rats.并探讨选择性一氧化氮合酶抑制剂—7-硝基-吲唑(7-NI)对大鼠HIBD时神经元凋亡的影响。
4)PGE_2,7-NIPGE_2,7-硝基吲唑
5)5-Nitroindazole5-硝基吲唑
6)methylindazole甲基吲唑
延伸阅读
硝基分子式:CAS号:性质:又称硝酰基。硝酸分子中去掉一个羟基后,剩下的基团。硝基与其他基团(主要是烃基)相连的化合物称为硝基化合物。硝基化合物(尤其是芳香族硝基化合物)具有毒性,分子中引入多个硝基后不仅毒性增加,而且氧化性也增强,且大多成为具有爆炸性的物质。硝基是又发色团,能加深色原体的颜色;有些药物中引入硝基以增强抗菌性;往有机分子(也有少数无机分子)中引入硝基的反应称为硝化反应(nitration)。
