1)hypoxia inducible factor-1α乏氧诱导因子-1α
1.Objective To investigate the expression of hypoxia inducible factor-1α(HIF-1α)and microvessels density(MVD),and further to evaluate the correlation between them.目的观察乏氧诱导因子-1α(HIF-1α)和微血管密度(MVD)在S180肉瘤中的表达水平,并探讨两者间的相关性。
2.Methods:A549 cell line(human lung adenocarcinoma) was cultured under hypoxic atmosphere(2% O_2) for 24 h,the expression of hypoxia inducible factor-1α、P-gp and P53 protein was detected by immu.方法:乏氧条件下(2%O2)人肺腺癌细胞株A549体外培养24 h,免疫组化法检测乏氧诱导因子-1α(H IF-1α)、P-糖蛋白(P-gp)和P53蛋白的表达;MTT法检测乏氧条件下A549细胞在多柔比星作用下的存活率;应用流式细胞仪检测细胞凋亡。
3.Objective To investigate the correlation between the expression of DNA-dependent protein kinase (DNA-PK) and hypoxia inducible factor-1α (HIF-1α) induced by irradiation in hypoxic HeLa cell and the modulatory mechanism.目的初步探讨辐射效应诱导下乏氧人宫颈癌细胞系HeLa细胞乏氧诱导因子-1α(HIF-1α)和DNA依赖蛋白激酶(DNA-PK)表达相关性及其调控机制。
英文短句/例句
1.Study on Reversing Hypoxia-Induced Chemo-and Radio-resistances by Targeting on Hypoxia Inducible Factor-1α in Lung Cancer Cells;乏氧诱导因子-1α基因沉默逆转肺癌细胞放化疗耐受的研究
2.Relationship between HIF-1 Alpha and Angiogenesis, Chemotherapy Response and the Mechanism in Esophageal Squamous Cell Carcinoma;乏氧诱导因子-1α与食管鳞癌血管生成和化疗疗效的关系及其机制
3.Experimental Study of the Correlation between Hypoxia Inducible Factor-1a and Microvessel Density;乏氧诱导因子-1α与微血管密度表达水平相关性的实验研究
4.Expression of Hypoxia Inducible Factor-1α in Nasopharyngeal Carcinoma and Its Clinical Value乏氧诱导因子-1α在鼻咽癌中的表达及其临床意义
5.Anti-tumor effect of silencing Hif-1α and Survivin genes combined with X-ray irradiation on hypoxic tumor cells in vitro沉默乏氧诱导因子-1α和生存素基因联合X射线照射对乏氧细胞的体外抑瘤效应
6.Construction of RNAi adenoviral shuttle vector targeting both HIF-1α and survivin synchronously靶向乏氧诱导因子-1α和生存素基因的RNA干扰腺病毒穿梭载体的构建
7.Expression and Significance of Hypoxia of Inducible Factor-1α in Osteosarcoma;乏氧诱导因子1α在骨肉瘤中的表达及其意义
8.Gene Cloning of Hypoxia-inducible Factor-1α and Expression Research of HIF-1α-pcDNA3.1;缺氧诱导因子1α基因克隆及HIF-1α-pcDNA3.1表达研究
9.The Effects of Hypoixa-Inducible Factor-1a on Gastric Cancer During Hypoixa;缺氧诱导因子-1α对缺氧胃癌细胞的影响
10.Expression of Hypoxia Inducible Factor la Gene and Protein in Human Endometrium人子宫内膜组织中缺氧诱导因子-1α(HIF-1α)基因和蛋白的表达
11.Correlation of hypoxia inducible factor 1-α polymorphism and nasopharyngeal carcinoma缺氧诱导因子-1α基因多态性与鼻咽癌的关系
12.The Expression of Hypoxia-inducible Factor-1alpha and Inducible Nitric Oxide Synthase in Inflammatory Bowel Disease;低氧诱导因子-1α、诱导型一氧化氮合酶在炎症性肠病中的表达
13.The Research on Relationship between HIF-1 Alpha Gene and Radiosensitivity in Esophageal Carcinoma Cells;缺氧诱导因子-1α（HIF-1α）表达与食管癌放射敏感性关系的研究
14.Inhibition of the Expression of HIF-1α and Angiogenic Factors with Specific Si RNA Targeting HIF-1α in HCC Cell under Hypoxia;HIF-1α siRNA干扰缺氧诱导人肝癌细胞HIF-1α及血管生成因子的表达
15.The Effect of Hypoxia Inducible Factor 1 Alpha Antisense Oligonucleotides on Cell Proliferation of Cervical Carcinoma;缺氧诱导因子-1α（HIF-1α）反义寡核苷酸对宫颈癌细胞增殖的影响
16.The Effect of Different Degree Expression of Hypoxia Inducible Factor-1α (HIF-1α) to Apoptosis of Nucleus Pulposus Cell;不同程度低氧诱导因子-1α（HIF-1α）表达对髓核细胞凋亡的影响
17.Study of Hypoxia-inducible Factor-1α on Carcinogenesis of Esophageal Squamous Cell Cancer;缺氧诱导因子1α在食管鳞癌发病机制中的研究
18.Experimental Research in Targeting Hypoxia-inducible Factor-1α for Pancreatic Cancer Therapy;缺氧诱导因子-1α在胰腺癌中的靶向治疗研究
相关短句/例句
HIF-1α乏氧诱导因子-1α
1.Effects of silencing HIF-1α gene by RNA interference on Taxol-induced apoptosis of human esophageal squamous cell line EC9706;RNA干扰沉默乏氧诱导因子-1α对紫杉醇诱导食管鳞癌EC9706细胞凋亡的影响
2.Construction of RNAi adenoviral shuttle vector targeting both HIF-1α and survivin synchronously靶向乏氧诱导因子-1α和生存素基因的RNA干扰腺病毒穿梭载体的构建
3.In order to investigate the anti-tumor effect of RNA interference silencing HIF-1α and Survivin genes combined with X-ray irradiation on hypoxic SMMC-7721 cells in vitro, we detected mRNA and protein expression of HIF-1α and Survivin genes in hypoxic SMMC-7721 cells after transfection with pGenesil-Survivin-HIF carried by liposome by RT-PCR and Western blot respectively.为探讨RNA干扰(RNAinterference,RNAi)沉默乏氧诱导因子-1α(Hypoxia induced factor 1α,HIF-1α)和生存素(Survivin)基因联合X射线照射对乏氧人肝癌细胞SMMC-7721的体外抑瘤效应,利用双靶向HIF-1α和Survivin基因载体,采用阳离子脂质体介导法转染SMMC-7721细胞,经乏氧培养36h后,分别以RT-PCR和Western blot法检测HIF-1α和Survivin基因的mRNA及其蛋白表达,分别以四甲基偶氮唑盐(MTT)法和流式细胞术检测细胞存活分数及细胞凋亡。
3)Hypoxia inducible factor 1α乏氧诱导因子-1α
4)HIF-1α乏氧诱导因子1α
1.Objective To evaluate the feasibility of HIF-1α(hypoxia induce factor-1α)expression and SPECT image with ~(99)Tc~m-EC-MNZ (~(99)Tc~m-EC-metronidazaole) in detecting tumor hypoxia,and to observe the correlation between these two methods.目的探讨肿瘤乏氧诱导因子1α(HIF1α)表达及乏氧显像剂99TcmEC甲硝唑(metronidazole,MNZ)SPECT显像对检测肿瘤乏氧(缺氧)程度的可行性,以及两种检测方法的相关性。
5)C-erbB-2·Hypoxia inducible factor-1C-erbB-2·乏氧诱导因子-1α
6)Hypoxia-inducible factor-1α缺氧诱导因子-1α
1.Expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in the retina of diabetic rats;糖尿病大鼠视网膜中缺氧诱导因子-1α和血管内皮生长因子表达的研究
2.Effects of Chinese herbs for replenishing qi and resolving stagnation on hypoxia-inducible factor-1α and vascular endothelial growth factor in granulation tissue of skin ulcers in rats with diabetes;益气化瘀中药对糖尿病皮肤溃疡大鼠缺氧诱导因子-1α和血管内皮细胞生长因子的影响
3.Expression of hypoxia-inducible factor-1α in endometriosis;缺氧诱导因子-1α在子宫内膜异位症的表达及意义
延伸阅读
α,α,α,α',α',α'-六氯对二甲苯分子式：C8H4Cl6分子量：312.84CAS号：68-36-0性质：白色针状或粉末状结晶。熔点108-110℃。溶于二甲苯、石油醚、乙醇、植物油，不溶于水。无味，有特殊臭味，遇光、碱会缓慢分解而呈酸性。制备方法：以混二甲苯为原料，先用98%硫酸磺化，使间二甲苯生成间二甲苯磺酸盐。从磺化反应物中分离出含邻、对二甲苯的油层，水洗、干燥，减压蒸馏出邻、对二甲苯。间二甲苯磺酸盐经水解可得副产品间二甲苯。由邻、对二甲苯经氯化即得1，4-双（三氯甲基）苯：在反应锅中投入邻、对二甲苯，再加入过氧化苯甲酰和三乙醇胺。加热到70℃后，在光照射下导入氯气，于70-80℃反应6h，再升温至100-120℃继续反应，至反应液相对密度达到1.560-1.580（65℃），即为反应终点，停止通氯，减压脱除余氯。降温至5℃，过滤，洗涤得粗品，重结晶，活性炭脱色得成品。用途：抗血吸虫病药物。对肝吸虫病、阿米巴原虫病、疟疾以及肠道线虫有一定疗效。但对神经系统的不良反应较多见，且延迟反应持续较久。
