酮内酯,ketolide
1)ketolide酮内酯
1.Studies on the synthetic procedure of a novel ketolide,cethromycin;新型酮内酯赛红霉素的合成研究
2.The Studies on Synthesis of Telithromycin and the Novel Ketolide Compounds, the Determination of Their Antibacterial Activities and the Study on Structure-activity Relationships;大环内酯类抗生素Telithromycin与酮内酯新化合物的合成、抗菌活性测定及构效关系研究
3.A new process for preparation the ketolide antibiotic telithromycin by multistep reactions started from clarithromycin is reported.以克拉霉素为原料,经多步反应制得酮内酯类抗生素泰利霉素。
英文短句/例句

1.Synthesis and Antibacterial Activity of the New C_(12) Pyrazolinonyl Ketolide新型C_(12)吡唑啉酮酮内酯的合成与抗菌活性
2.Study on Relationship between Thioesterase Domain and Ketolide Biosynthesis;硫酯酶结构域和酮内酯类化合物生物合成之间关系的研究
3.Synthesis of two kinds of ketolides,telithromycin and cethromycin酮内酯类抗生素——泰利霉素和喹红霉素的化学合成
4.Content Determination of Terpene Lactones in Yinxing Tongzhi Capsules by HPLC-ELSDHPLC-ELSD法测定银杏酮酯胶囊中萜类内酯的含量
5.Synthesis of three derivatives 3-oxime of spirolactone compounds三个甾体螺内酯-3-酮肟化合物的合成
6.Asymmetry Reduction of Ketopantolactone by Baker's Yeast面包酵母不对称还原酮基泛解酸内酯
7.Research on the Selection of Ginkgo Biloba Cell Lines Highly Producing Flavone Glycoside and Terpene as well as the Regulation of Flavone Glycoside Synthesis;高产黄酮苷和萜内酯银杏细胞系选育及黄酮苷积累调控的研究
8.Simultaneous Determination of Four Chromones,Three Flavonoids and Two Atractylenolqides in Yupingfeng Powder by HPLCHPLC法同时测定玉屏风散中色原酮、黄酮和内酯类9种成分的含量
9.Isolation and identification of the diterpenoid and flavone in Scutellaria barbata D. Don半枝莲中二萜内酯和黄酮化合物的分离和鉴定
10.Biotransformation of Triptolide and Triptonide by Plant Cell Suspension Cultures and Microbes;雷公藤甲素和雷公藤内酯酮的生物转化研究
11.Synthesized of Carabrone Derivatives and Their Antifugal Activities;天名精内酯酮的衍生合成及其抑菌活性研究
12.Study on the Variation Pattern of Flavonoid & Ginkgolides from Ginkgo Biloba in Shaanxi Province陕西银杏药用成分黄酮、内酯变异规律研究
13.Synthesis and Antifugal Activities of Carabrone Ester Analogues天名精内酯酮酯类衍生物的合成及其对黄瓜炭疽病菌的抑菌活性
14.The Expression of HMGB1 and the Depressant Effect of Ethyl Pyruvate in Endotoxin-Stimulated Macrophages;内毒素血症巨噬细胞HMGB1的表达及丙酮酸乙酯对其的抑制作用
15.Studies on Regulation of Ginkgo Flavones and Ginkgolides Accumulation in Cultured Cells of Ginkgo Biloba L. and Their Pharmacology;银杏黄酮和内酯在银杏细胞培养中积累的调控及其药理研究
16.Stynthesis of P-dioxanone/ε-caprolactone Copolymer and Their Structures and Properties;对二氧环己酮/ε-己内酯共聚物的合成及结构性能研究
17.Syntheses and Structures of Lanthanide Complexes Supported by β-Diketiminato Ligand Systems and Their Catalytic Activity for the polymerization of ε-caprolactone;β-二酮亚胺基稀土配合物的合成、结构及催化已内酯聚合研究
18.The Study of Pharmacokinetics and Relative Bioavailability of Spironolatone Metabolite Canrenone in Healthy Chinese Volunteers;螺内酯代谢物坎利酮健康人体药动学和相对生物利用度研究
相关短句/例句

Ketolides酮内酯
1.A Brief Introduction on Macrolides Antibiotics of Novel Generation Ketolides;新一代大环内酯类抗生素——酮内酯类简介
2.The novel generation macrolide erythromycin derivatives have shown the improved pharmacokinetics profiles and the high activity against resistant strains,in which ketolides are the representative compounds,thus become the development emphasis for macrolide antibiotics.以酮内酯为代表的新一代大环内酯类红霉素衍生物具有良好的药动学性质,且对耐药菌有很好的活性,成为近年来大环内酯类抗生素研发的重点。
3.According to the SAR study of ketolides and the bio-isostere principle,a new type of ketolide(1),bearing a C12 pyrazolinonyl moeity instead of the C11,12 cyclic carbamate group in telithromycin,was designed and synthesized starting from clarithromycin derivatives.根据酮内酯的构效关系和生物电子等排原理,设计、合成了新型C12吡唑啉酮酮内酯(1)。
3)ketolides酮内酯类
1.Telithromycin is the first member of a new family of the macrolide lincosamide streptogramin B class of antimicrobials,the ketolides.泰利霉素是大环内酯 林可酰胺 链阳霉素B新家族中的第一个抗菌药物 ,属酮内酯类抗生素 ,具有广谱抗菌活性和较低的选择性耐药性 ,以及与其他酮内酯类抗生素的交叉耐药性。
4)ketolide酮内酯类
1.Study on relationship between thioesterase domain and synthesis of ketolide;硫酯酶结构域对酮内酯类化合物合成的影响
2.Since the formation of C-3 ketone group of macrolactone ring depended on the ketoreductase (KR) domain of the sixth module of polyketide synthase that catalyzed the synthesis of 6-deoxy-erythronolide B, we could make KR6 domain inactivated or deleted by genetic engineering for ketolide biosynthesis.利用染色体同源重组技术已构建了一系列糖多孢红霉菌KR6突变体,均合成酮内酯类化合物3-脱氧-3-羰基-6-脱氧-红霉内酯B(3-deoxy-3-oxo-6-deoxy-erythronolide B,DODEB),并进一步被羟基化修饰为3-脱氧-3-羰基-红霉内酯B(3-deoxy-3-oxo-erythronolide B,DOEB),然而产量比较低。
5)non-ketolides非酮内酯
6)ketolide and acylide酮内酯和酰内酯
延伸阅读

17α-(2-羧乙基)-17β-羟基雄甾-4,6-二烯-3-酮内酯分子式:C22H28O3分子量:340.47CAS号:976-71-6性质:微黄色或乳白色结晶性粉末(乙酸乙酯)。熔点149-151℃,165℃固化并重熔。制备方法:可用17-羟基-3-氧代-17α-孕甾-4-烯-21-羧酸-γ-内酯经脱氢制得。而前者则可从17α-炔基-3β,17β-二羟基雄甾-5-烯(即乙炔雄甾烯二醇)经炔基以甲基碘化镁置换、水解、成盐并催化氢化,生成3β,17β二羟基雄甾-5-烯-17α-丙酸钾,然后经内酯化及3-位羟基氧化制得该品。用途:安体舒通的中间体。本身为醛甾酮拮抗剂。