1)differentially co-expressed disease-related genes差异共表达致病基因
1.Finding differentially co-expressed disease-related genes based on mutual information基于互信息的差异共表达致病基因挖掘方法
英文短句/例句
1.Finding differentially co-expressed disease-related genes based on mutual information基于互信息的差异共表达致病基因挖掘方法
2.Differential Expression of Wheat Leaf Rust Resistance Gene Lr41;小麦抗叶锈病基因Lr41差异表达研究
3.Investigation of the Radiation Carcinogen Differential Expression Gene Screened by DDRT-PCR;DDRT-PCR筛选辐射致癌差异表达基因的研究
4.The study of periodontal pathogens LPS on the gene expression patterns in PDLCs and the specific detection and treatment of periodontal mocrobiota;牙周致病菌的特异检测、治疗及其内毒素刺激人牙周膜细胞差异表达基因的研究
5.Differential Gene Expression of Porcine Alveolar Macrophage Associated with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection高致病性猪繁殖与呼吸综合征病毒感染后猪肺泡巨噬细胞的差异表达基因的研究
6.Preliminary Analysis on Ratinal Gene Expression Profile of Diabetic Rat;糖尿病大鼠视网膜基因表达谱差异初步分析
7.mRNA Expression Difference of Six Near-isogenic Lines for Wheat Leaf Rust Resistance Genes;六个小麦抗叶锈病近等基因系mRNA表达差异研究
8.Study on Gene Differential Expression of the Interaction between Sugarcane and Smut Caused by U.stilago Scitaminea Syd;甘蔗与黑穗病菌互作的基因差异表达研究
9.Study on the Differential Display of Genes Related to Gastric Cancer and Its Premalignant Lesion;胃癌及其癌前病变相关基因差异表达的研究
10.Differential Expression Analysis of Ht2-Related Genes in Reaction to HT-Toxin and to Exserohilum Turcicum玉米抗大斑病Ht2相关基因的差异表达分析
11.Expression Analysis of Rice Difference Genes Induced by Rhizoctonia Solani纹枯病菌诱导的水稻差异基因表达分析
12.Differential Gene Expression in Early Development of Fetuses of Diabetic Mice糖尿病小鼠胚胎早期发育的差异表达基因
13.Study on the differentially expressed genes in vascular tissue of diabetic gangrene糖尿病坏疽血管组织中差异表达基因的研究
14.Screening of differentially expressed genes in heat-stressed mouse testis by construction of a subtractive cDNA library用差减cDNA文库筛选由热激导致的小鼠睾丸中差异表达的基因
15.Verify the Alternations of Transcriptional Profile in AHH-1 Co-culture with Same Cells Irradiated by ~(60)γ-ray and Analysis the Array Data by Bioinformatics辐射致AHH-1旁效应差异表达基因信息分析及部分基因研究
16.Construction of a Naked Barley SSH cDNA Library Against BYDV and Isolation of Different Expression Genes青稞抗黄矮病抑制差减文库的构建及差异表达基因的分离
17.Identification, Verification and Functional Analysis of Differentially Expressed Genes in Hyperthermia Induced Neural Tube Defects of Golden Hamster;高温致金黄地鼠神经管畸形差异表达基因的筛选、鉴定及功能研究
18.Relationship between the Differential Expressions of Sucrose-metabolism Related Genes and Cariogenicity of S. Mutans;变形链球菌糖代谢相关基因的差异性表达与其致龋性关系的研究
相关短句/例句
differentially expressed genes差异表达基因
1.Analyses on the differentially expressed genes associated with murine double minute 2/p53 pathway in breast cancer;mdm2/p53通路相关的乳腺癌差异表达基因分析
2.Screening of differentially expressed genes in rat brain repeatedly exposed to+Gz;正加速度重复暴露大鼠脑差异表达基因的筛选
3.Cloning and screening of differentially expressed genes from the male gametophytes of Laminaria japonica Aresch;海带雄性配子体差异表达基因片段的克隆及筛选
3)differential gene expression差异基因表达
1.To elucidate the differential gene expression during the development of stamens in female flower buds of bitter melon gynoecious line induced with AgNO3, in the present study, it was studied at the levels of morphology and transcription genomics using morphologic observations, cDNA-AFLP, RT-PCR and reverse-Northern hybridization.为了研究AgNO3诱导下纯雌系苦瓜花蕾发育过程中的差异基因表达,本文运用形态学观察、cDNA-AFLP、RT-PCR和反向Northern杂交等技术在形态学和转录组学水平上对花蕾转雄进行了研究。
4)differentially expressed gene差异表达基因
1.Detection of differentially expressed genes in human autosomal dominant polycystic kidney tissue;常染色体显性多囊肾组织差异表达基因的初步研究
2.Cloning of differentially expressed genes of eosinophils from asthmatic patients by suppression subtractive hybridization;应用抑制消减杂交克隆支气管哮喘病人嗜酸细胞差异表达基因
3.Screening of differentially expressed genes in the regeneration of injured spinal cord of neonatal rats;新生大鼠脊髓损伤修复差异表达基因的筛选
5)gene different expression基因差异表达
6)differential gen expression差异性基因表达
延伸阅读
表达谱差异分析表达谱差异分析(differential expression profiling)主要包括基因表达谱(gene expression profiling) 和蛋白质表达谱(protein expression profiling) 。大规模表达谱分析已经成为认识疾病分子机制的有利方法,在癌症研究等方面取得了一定的进展。成功的表达谱分析基于实验及其过程分析的有机结合。实验过程从关注的疾病开始,首先收集大量的疾病相关组织样本,样本数量可从10 多个到数百个,但必须足以对每一组织类型及个体差异进行比较分析,而且许多情况下不能仅简单地分为正常和疾病组织。例如,在对糖尿病的研究中,所收集的样本来自健康人、胰岛素耐受和糖尿病病人的不同试验阶段,如胰岛素治疗前后。样品还应包括其他器官的取材,以便进行基因表达的组织分布研究。为了便于对后来的实验数据进行分析管理,需采集并储存所有的组织样本和临床参数。接下来进行组织样本的处理,利用生物芯片(寡核苷酸芯片、cdna 芯片或全基因组芯片) 进行表达谱测定,并进行生物信息学分析。通常,表达谱的分析结果需进一步的实验加以证实。定量rt2pcr 是最灵敏的确证方法,该方法还可以将确证实验的范围扩大到原测组织以外的更广泛的组织和组织类型,揭示基因表达的组织分布情况。确证实验揭示了疾病相关基因。据此,可以进行进一步研究,探索这些基因的功能,开发新的治疗手段。例如,对于正常和疾病组织中表达有显著性变化的基因,可以进行新治疗靶点的鉴定和确定研究,或利用实验和分析工具研究分析其功能;对于疾病组织中活性升高的酶,可以当作前药活化酶进行鉴定研究。典型的表达谱能够显示疾病过程中有大量的已知基因表达的改变,而许多已知基因的代谢通路、表达产物酶学分类和蛋白质功能业已发表,将两者对照分析,可以鉴定出酶活性,选择其中可能成为前药活化酶的部分进行进一步研究;对于疾病特异的蛋白质,可以进行抗原表型分析,决定疫苗的开发策略。寻找差异表达基因的方法除芯片技术外,一些新的检测方法如差异显示pcr ( differential display pcr, dd－pcr) 、消减杂交( suppression subreactive hy bridization , ssh) 等也相继得到结合应用。
