HDAC抑制剂,HDAC inhibitors
1)HDAC inhibitorsHDAC抑制剂
1.Structure based virtual screening of HDAC inhibitors;组蛋白去乙酰化酶是抗肿瘤作用的新靶点,基于该酶复合物的三维结构,首先对具有分子多样性的数据库进行了虚拟筛选;然后根据已知HDAC抑制剂的结构特征和筛选的结果,以及与生物大分子互补性,选择合理的构建单元,组建靶向的虚拟组合库;最后进行数据库虚拟筛选,对分子对接的结果进行评分,选择出理论上与HDAC有较好结合能力的化合物,设计了酰胺类、脲类和酰肼类全新结构类型的HDAC抑制剂,初步生物活性评价结果表明,预期有生物活性的化合物显示出一定的HDAC酶抑制活性。
英文短句/例句

1.Investigation of the Mechanism of Tumor Cell Apoptosis Induced by HDAC Inhibitor;HDAC抑制剂抗肿瘤效应的机制研究
2.Investigation of the Target Genes Involved in Tumor Cell Apoptosis Induced by HDAC InhibitorHDAC抑制剂抗肿瘤效应靶基因的研究
3.Effects of Differentiation Induced by SAHA on the Human Hepatoma Cells;HDAC抑制剂SAHA对人肝癌细胞分化诱导作用的研究
4.Effects of Differentiation Induced by SAHA on the Human Osteosarcoma CellsHDAC抑制剂SAHA对骨肉瘤细胞分化诱导作用的研究
5.HDAC Inhibitor TSA Induced Apoptosis and Growth Arrest in Breast Cancer CellsHDAC抑制剂TSA抑制乳腺癌MCF-7细胞增殖并促进乳腺癌细胞凋亡
6.Chondrocytes Differentiation of Bone Marrow-derived Mesenchymal Stem Cells Induced by HDAC Inhibitor in Vitro;HDAC抑制剂诱导骨髓间充质干细胞向软骨细胞分化及机制的研究
7.Study on the Mechanism of Apoptosis Through Activation of the Death Receptor Pathway by HDAC Inhibitor in Leukemia Cells;HDAC抑制剂激活死亡受体通路诱导白血病细胞凋亡的机制研究
8.Design, Synthesis and Antitumor Activities of Benzamide Derivaterives as Novel Histone Deacetylase Inhibitors新型苯甲酰胺类HDAC抑制剂设计、合成及抗肿瘤活性评价
9.Effect of HDAC Inhibitor on Histone Acetylation and the Expression of ASC in LS174T CellsHDAC抑制剂对LS174T细胞组蛋白乙酰化及ASC基因表达的作用
10.Role of histone deacetylase in inhibiting invasion of human gastric carcinoma cell line SGC-7901 by PPARγ-mediated pathwayHDAC在PPARγ途径抑制胃癌SGC-7901细胞侵袭中的作用
11.foam suppressor泡沫抑制剂,消泡剂
12.The organic depressors for depressing arsenopyrite include small and large molecular organic depressors.砷黄铁矿有机抑制剂包括小分子有机抑制剂和大分子有机抑制剂。
13.Study on the inhibition of growth hormone inhibitor to the sarcoma 180生长激素抑制剂抑制肉瘤180的研究
14.Study on Selectivity of Inhibitor BD2 for PKA over PKC βⅡ抑制剂BD2对PKA与PKCβⅡ的抑制选择性研究
15.The effect of COX-2 inhibitor on bladder cancerCOX-2抑制剂对膀胱肿瘤的抑制作用
16.γ-secretase inhibitor DAPT suppresses the proliferation of Jurkat T cellsγ-分泌酶抑制剂DAPT抑制Jurkat T细胞增殖
17.evaporation suppressant土地水分蒸发抑制剂
18.choline esterase inhibitor胆碱酯酶抑制作用剂
相关短句/例句

histone deacetylase (HDAC) inhibitors组蛋白去乙酰酶(HDAC)抑制剂
3)checkpoint kinase 2(Chk2)inhibitorChk2抑制剂
4)inhibitors抑制剂
1.Improvement of measurement method of tyrosinase activities in agaricus bisporus and screening of inhibitors of tyrosinase;双孢菇酪氨酸酶测活方法的改进及其抑制剂的筛选
2.Effect of browning inhibitors and hardener on browning and quality of boiled lotus root;抑制剂与硬化剂对水煮莲藕褐变及品质的影响
3.Selection of browning inhibitors of the artichokes;菊芋酶促褐变抑制剂的筛选
5)inhibitor[英][in'hibit?][美][?n'h?b?t?]抑制剂
1.Effect on PE and PG activity of commol/Lercial pectinase preparation by inhibitors;抑制剂对商品果胶酶中果胶酯酶和聚半乳糖醛酸酶酶活的影响
2.Effect on expression yield of the recombinant kiwi pectin methylesterase inhibitor in different fermentation conditions;不同发酵条件对重组猕猴桃果胶甲酯酶抑制剂表达量的影响
3.Application of Alcohol Dehydrogenase Immobilized on Core-shell Nanoparticles to Screening Inhibitors by HPLC;应用壳核纳米微球固定乙醇脱氢酶联用HPLC对抑制剂筛选
6)enzyme inhibitor酶抑制剂
1.Advance in the antiviral enzyme inhibitors;酶抑制剂类抗病毒药物的研究进展
2.The ability of microorganisms (Nocardia, Mycobacterium and Arthrobacter) is studied to degrade the soybean sterol, the influence of enzyme inhibitors, which inclus Ni2+.测定了诺卡氏菌(Nocardia)、分枝杆菌(Mycob acterium)和节杆菌(Arthrob acter)对大豆甾醇的降解能力及Ni2+,Co2+,Mn2+,α、α’-联吡啶、邻菲罗琳等酶抑制剂对△1,4-雄甾二烯-3, 17-二酮(ADD)积累的影响。
3.OBJECTIVE: To screen and isolate the cholesterol biosynthetic enzyme inhibitors from SIPI 17.目的:筛选和分离微生物产生的胆固醇生物合成酶抑制剂。
延伸阅读

benzidine hdacCAS: 52754-64-0 分子式: C12H12N2·CH3COOH 中文名称: 联苯胺乙酸盐 英文名称: benzidine hdac