1)Chemoresistance[,kem?ri'zist?ns]化疗耐药
1.Mutation, translocation and loss of some genes have been known to contribute to chemoresistance, epigenetic mechanisms may also play an important role.表观遗传(eprgenetic)和基因突变、易位、缺失等事件同样在化疗耐药的形成中有重要的作用。
2.In order to study the relationship between the expression of glutathione S transferase(GST) in leukemic cells and the chemoresistance in patients with acute leukemia, the expressions of GST activity and GST mRNA were measured according to spectrophotometric assay based on the use of 1 choloro 2, 4 dinitro benzene and in situ hybridization.为了探讨白血病细胞内谷胱甘肽硫转移酶 (GST)的表达与化疗耐药的关系 ,本研究采用 1 氯 2 ,4 二甲基为底物的比色分析法和原位杂交法对 5 6例白血病患者白血病细胞内GST的表达进行检测 ,并结合临床化疗药物敏感度和治疗效果进行临床分析。
3.Objective To investigate the impacts of cytotoxic drugs on APE/ref-1 expression in A549 cell, in order to find the potential relationship between APE/ref-1 and chemoresistance of NSCLC.结论 APE/ref-1表达增强及其在细胞内不同部位表达强度的变化可能和NSCLC对化疗耐药性的产生相关。
英文短句/例句
1.Chemoimmunotherapy of chemotherapy-refractory metastatic colorectal cancer with gemcitabine plus FOLFOX followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2GOLFIG-1在化疗耐药转移性结肠癌中的疗效
2.Expressions of XIAP in Renal Cell Carcinoma (RCC) and Its Role in Drug Resistance of RCC;XIAP在肾癌中的表达及其与肾癌化疗耐药的关系
3.The Expression of Livin in Gastric Cancer and It s Mechanism of Resistance to Chemotherapy;Livin在胃癌中表达及其与化疗耐药的机制
4.Study of the Relationship between Ku Protein Expression and Lung Cancer Drug Resistance;Ku蛋白表达与肺癌化疗耐药性关系的研究
5.EGFR mRNA and Angiogenesis, Chemotherapy Resistance in Ovarian CarcinomaEGFR mRNA与卵巢癌血管生成及化疗耐药关系的研究
6.Studies on Oriented Drug and Tolerability to Chemotherapeutic Drug of MDR1 Gene;MDR1的导向药物及其耐化疗药的研究
7.MDR1 Gene Transfection to Improve the Effect of Hepatocarcinoma Mice High-dose Chemotherapy;转染多药耐药基因提高小鼠肝癌化疗疗效研究
8.Study of microcalory united with chemotherapeutics on tuberculosis of more drugs fast微卡联合化疗药物治疗耐多药肺结核的研究
9.Effect of hyperthermia and chemotherapy on CBRH-7919mdr MDR gene高温合并化疗对耐药性大鼠肝癌CBRH-7919细胞多药耐药基因的影响
10.Experimental Study of Chemosensitivity of Human Ovarian Cancer Cisplatin-resistant Cells顺铂耐药卵巢癌细胞化疗敏感性实验
11.chemical proofing耐药品性,耐化学药品性
12.Efficacy Analysis of Youfuning、Thymosin and Chemical Drug on MDR-TB优福宁 胸腺肽联合化疗药物治疗耐多药肺结核疗效分析
13.Prevalence and Evolution of HIV-1 Drug Resistance in Patients Receiving Free Antiretroviral Therapy in China;我国HIV-1免费抗病毒治疗患者基因型耐药性及耐药进化研究
14.Analysis of drug resistance in 165 multidrug-resistance pulmonary tuberculosis patients before and during the treatment165例耐多药肺结核病人治疗前后耐药谱的变化分析
15.Serial chemosensitivity test for liver cancer chemotherapy系列化疗药敏或耐药试验在肝癌化疗中的应用研究
16.Short term and long term effect of Siqikang on retreated multi-drug resistant tuberculosis patients斯奇康联合化学药物治疗复治及耐多药肺结核疗效观察
17.Study on Improving Resistance of Human Hematopoietic Progenitor Cells to Chemotherapeutic Agents in Vitro by Transduction of Multidrug Resistance Gene;多药耐药基因转导提高人造血祖细胞对化疗药物抗性的体外研究
18.Correlation of expression of HIF-1α with MDR-related factors and chemosensitivity in gastric carcinoma tissues胃癌组织HIF-1α表达与多药耐药因子及体外化疗药敏性的关系
相关短句/例句
Chemotherapy resistance化疗耐药
3)Drug resistance化疗耐药
1.Study on drug resistance in pediatric leukemia;儿童急性淋巴细胞白血病细胞化疗耐药机制的探讨
4)chemoresistance[,kem?ri'zist?ns]化疗耐药性
1.Activity of PI3 K/Akt/FKHRL1 signaling pathway induced by Doxorubicin confer chemoresistance in gastric cancer cell;阿霉素诱导PI3’K/Akt/FKHRL1通路激活与胃癌细胞化疗耐药性的关系
2.【Objectives】 To investigate the changes of CN-Ⅱand APE / Ref-1 expression in human lung cancer cell line A549 after induction of gemcitabine and to study the effects of gemcitabine on chemoresistance in lung cancer.【结论】CN-Ⅱ和APE/Ref-1在肺癌化疗时表达明显增强,可能与化疗耐药性的产生有关,并提示针对CN-Ⅱ和APE/Ref-1的靶向干预可能有助于提高肺癌的化疗敏感性。
5)chemotherapy resistance化疗耐药性
1.To investigate the relationship between the expression of NFkB family proteins, P53 and MDM2 in ovarian cancer cell lines and chemotherapy resistance of ovarian cell lines, 13 ovarian cancer cell lines were cultured, and then protein was extracted separately from cytoplasm, nuclear or total cells.培养13个卵巢癌细胞系,提取癌细胞蛋白,采用Western印迹法观察NFkB家族蛋白、P53和MDM2的表达,并用四氮唑盐法药敏试验观察与卵巢癌细胞化疗耐药性关系。
6)Chemotherapy drug resistance化疗药物耐药
延伸阅读
抗癌化疗药分子式：CAS号：性质：又称抗癌(化疗)药，抗癌药。能抑制和杀伤恶性肿瘤细胞的一类药物。在肿瘤综合治疗中具有重要地位，特别对不能用手术治疗的白血病、播散型肿瘤的治疗尤为重要。目前应用的抗肿瘤药大多通过抑制DNA或RNA合成，甚至破坏DNA结构而发挥作用。根据期和G2期)，按药物对肿瘤细胞的影响，可将抗恶性肿瘤药分为两大类：(1)周期非特异性药物，对增殖中各期细胞均有杀灭能力，如烷化剂和抗癌抗生素等；(2)周期特异性药物，它仅对增殖周期中某一期有较强作用，如羟基脲、阿糖胞苷、甲氨蝶呤等抗代谢药物对S期细胞特异性较高；长春新碱、秋水仙碱、博来霉素等对M期细胞作用显著。两类药物作用虽不相同，但对骨髓造血干细胞及其他生长周期短的细胞均有不同程度杀伤作用，并可抑制机体免疫反应。
