1.本发明公开涉及结合至血管内皮生长因子(vegf)和血管生成素(例如,血管生成素1和血管生成素2)两者的融合分子(例如,多肽)、基于这些融合分子的基因疗法及其使用方法。
背景技术:
0、2.背景技术
1、vegf/vegfr和血管生成素/tie-2信号转导通路在血管内皮生长(血管生成)过程中以及在血管生成相关血管的维持中是重要的。参见biela and siemann,cancerlett.380(2):525–533(2016)。异常血管生成涉及一些病况,如糖尿病性视网膜病、银屑病,渗出性或“湿性”年龄相关性黄斑变性(“wamd”)、类风湿性关节炎及其它炎性疾病和大部分癌症。与这些病况相关的患病组织或肿瘤通常表达异常高水平的vegf并且显示出高度的血管形成或血管通透性。例如,wamd是血管生成疾病,其特征为老年个体中的一只眼或两只眼中的脉络膜新生血管并且是致盲的主要原因。参见gehrs等人,ann med.38(7):450–471(2006)。存在用于抑制异常血管生成,靶向vegf或血管生成素的一些治疗策略。参见bielaand siemann,cancer lett.380(2):525–533(2016)。然而,这些治疗通常需要反复注射,其可以在一些患者中提高炎症、感染和其它不利影响的风险。反复注射还与患者的顺从性相关,并且坚持困难和不顺从性可以导致视力丧失和眼部疾病或病况的恶化。对于需要关于施用反复或频繁拜访医疗办公室的治疗方案的不顺从性和不坚持的比例在大部分受amd影响的老年患者中特别高。在本领域中,需要改善的治疗性分子,具体地在用于治疗疾病,如wamd的基因疗法中使用的治疗性分子。
2、3.发明概述
3、在一个方面,本文提供了多肽,其包含:(i)结合至vegf的第一结构域;(ii)结合至vegf的第二结构域;和(iii)结合至血管生成素(例如,血管生成素1和血管生成素2)的第三结构域。在一些实施方式中,第三结构域任选地处于第一结构域和第二结构域的n-末端。
4、在一些实施方式中,第一结构域来源于vegf受体-1(vegfr-1或flt-1)。在一些实施方式中,第一结构域包含vegfr-1的结构域2或其变体。在一些实施方式中,第一结构域包含seq id no:1所示的氨基酸序列或者由所述氨基酸序列组成。在一些实施方式中,第一结构域包含与seq id no:1具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列或者由所述氨基酸序列组成。
5、在一些实施方式中,第二结构域来源于vegf受体-2(vegfr-2或flk-1)。在一些实施方式中,第二结构域包含vegfr-2的结构域3或其变体。在一些实施方式中,第二结构域包含seq id no:2所示的氨基酸序列或者由所述氨基酸序列组成。在一些实施方式中,第二结构域包含与seq id no:2具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列或者由所述氨基酸序列组成。
6、在一些实施方式中,第三结构域(abd)包含seq id no:3所示的氨基酸序列的一个或两个重复。在一些实施方式中,第三结构域包含seq id no:51所示的氨基酸序列的一个或两个重复。在一些实施方式中,第三结构域包含seq id no:3所示的氨基酸序列的两个重复。在一些实施方式中,第三结构域包含seq id no:51所示的氨基酸序列的两个重复。在一些实施方式中,第三结构域包含seq id no:3所示的氨基酸序列和seq id no:51所示的氨基酸序列。
7、在一些实施方式中,第三结构域包含seq id no:4所示的氨基酸序列或者由所述氨基酸序列组成,或者第三结构域包含与seq id no:4具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列。
8、在一些实施方式中,第三结构域包含seq id no:52所示的氨基酸序列或者由所述氨基酸序列组成,或者第三结构域包含与seq id no:52具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列。
9、在一些实施方式中,第三结构域包含seq id no:53所示的氨基酸序列或者由所述氨基酸序列组成,或者第三结构域包含与seq id no:53具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列。
10、在一些实施方式中,第三结构域包含seq id no:54所示的氨基酸序列或者由所述氨基酸序列组成,或者第三结构域包含与seq id no:54具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列。
11、在另一个方面,本文提供了多肽,其包含(i)结合至vegf的第一结构域,所述第一结构域包含与seq id no:1具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列;(ii)结合至vegf的第二结构域,所述第二结构域包含与seq id no:2具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列;和(iii)结合至血管生成素的第三结构域,所述第三结构域包含两条氨基酸序列,每条序列包含与seq id no:3具有至少80%、85%、90%或100%同一性的氨基酸序列。
12、在另一个方面,本文提供了多肽,其包含(i)结合至vegf的第一结构域,所述第一结构域包含与seq id no:1具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列;(ii)结合至vegf的第二结构域,所述第二结构域包含与seq id no:2具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列;和(iii)结合至血管生成素的第三结构域,所述第三结构域包含两条氨基酸序列,每条序列包含与seq id no:51具有至少80%、85%、90%或100%同一性的氨基酸序列。
13、在另一个方面,本文提供了多肽,其包含(i)结合至vegf的第一结构域,所述第一结构域包含与seq id no:1具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列;(ii)结合至vegf的第二结构域,所述第二结构域包含与seq id no:2具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列;和(iii)结合至血管生成素的第三结构域,所述第三结构域包含一条与seq id no:3具有至少80%、85%、90%或100%同一性的氨基酸序列,和一条与seq id no:51具有至少80%、85%、90%或100%同一性的氨基酸序列。
14、在一些实施方式中,所述多肽还包含抗体的fc区。在一些实施方式中,所述fc区包含seq id no:5所示的氨基酸序列。
15、在一些实施方式中,所述多肽还包含信号肽。在一些实施方式中,所述信号肽包含seq id no:6所示的氨基酸序列。
16、在一些实施方式中,所述多肽还包含一个或多个接头。
17、在一些实施方式中,本文提供了多肽,其包含seq id no:7、seq id no:8、seq idno:9或seq id no:10所示的氨基酸序列,或者与seq id no:7、seq id no:8、seq id no:9或seq id no:10具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列。
18、在一些实施方式中,本文提供了多肽,其包含seq id no:58、seq id no:59、seqid no:60、seq id no:61、seq id no:62、seq id no:63、seq id no:64、seq id no:65或seq id no:66所示的氨基酸序列,或者与seq id no:58、seq id no:59、seq id no:60、seqid no:61、seq id no:62、seq id no:63、seq id no:64、seq id no:65或seq id no:66具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%同一性的氨基酸序列。
19、在一些实施方式中,本文所提供的多肽还包含vegfc结合结构域。在一些实施方式中,所述vegfc结合结构域来源于vegfr-2。在其它实施方式中,所述vegfc结合结构域来源于vegfr-3。
20、在一些实施方式中,所述vegfc结合结构域包含与seq id no:55具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列。
21、在一些实施方式中,所述vegfc结合结构域包含与seq id no:56具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列。
22、在一些实施方式中,所述vegfc结合结构域包含与seq id no:57具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%同一性的氨基酸序列。
23、在一些实施方式中,所述多肽基因融合或化学缀合至试剂。
24、在另一个方面,本文提供了分离的核酸,其包含编码本文所提供的多肽的核酸序列。
25、在另一个方面,本文提供了载体,其包含本文所提供的分离的核酸。在一些实施方式中,所述载体是病毒载体。在一些实施方式中,所述病毒载体是腺病毒相关病毒(aav)载体。在一些实施方式中,所述aav载体来源于aav1、aav2、aav2i8、aav3、aav3-b、aav4、aav5、aav6、aav7、aav8、aavrh8、aavrh8r、aav9、aav10、aavrh10、aav11、aav12、aav13、aav-dj、aavlk03、aavrh74、aav44-9或其组合或变体。在一些实施方式中,所述载体是重组aav2(raav2)载体、重组aav8(raav8)载体或其变体。
26、在另一个方面,本文提供了重组aav(raav)载体,其包含编码多肽的核酸,其中所述多肽包含(i)来源于vegfr-1的第一结构域;(ii)来源于vegfr-2的第二结构域;和(iii)能够结合至血管生成素(例如,血管生成素1和血管生成素2)的第三结构域,其中所述raav载体包含来自下列的末端反向重复(itr):aav1、aav2、aav2i8、aav3、aav3-b、aav4、aav5、aav6、aav7、aav8、aavrh8、aavrh8r、aav9、aav10、aavrh10、aav11、aav12、aav13、aav-dj、aavlk03、aavrh74、aav44-9或其组合或变体。在一些实施方式中,所述itr来自aav2。在其它实施方式中,所述itr来自aav8。在一些实施方式中,第三结构域处于第一结构域和第二结构域的n-末端。
27、在另一个方面,本文提供了重组aav(raav)载体,其包含编码多肽的核酸,其中所述多肽包含(i)来源于vegfr-1的第一结构域;(ii)来源于vegfr-2的第二结构域;和(iii)能够结合至血管生成素的第三结构域;和(iv)能够结合至vegfc的第四结构域,其中所述raav载体包含来自下列的末端反向重复(itr):aav1、aav2、aav2i8、aav3、aav3-b、aav4、aav5、aav6、aav7、aav8、aavrh8、aavrh8r、aav9、aav10、aavrh10、aav11、aav12、aav13、aav-dj、aav lk03、aavrh74或aav44-9。在一些实施方式中,所述itr来自aav2。在其它实施方式中,所述itr来自aav8。在一些实施方式中,第三结构域处于第一结构域和第二结构域的n-末端。
28、在一些实施方式中,本文提供了载体,所述载体包含seq id no:11、seq id no:12、seq id no:13、seq id no:14、seq id no:15、seq id no:16、seq id no:17、seq idno:18、seq id no:19、seq id no:20、seq id no:21、seq id no:22或seq id no:23所示的核酸序列,或者与seq id no:11、seq id no:12、seq id no:13、seq id no:14、seq id no:15、seq id no:16、seq id no:17、seq id no:18、seq id no:19、seq id no:20、seq idno:21、seq id no:22或seq id no:23具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%的同一性的核酸序列。
29、在一些实施方式中,本文提供了载体,所述载体包含seq id no:67、seq id no:68、seq id no:69、seq id no:70、seq id no:71、seq id no:72、seq id no:73、seq idno:74或seq id no:75所示的核酸序列,或者与seq id no:67、seq id no:68、seq id no:69、seq id no:70、seq id no:71、seq id no:72、seq id no:73、seq id no:74或seq idno:75具有至少80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%的同一性的核酸序列。
30、在另一个方面,本文提供了重组aav(raav)颗粒,其包含(a)编码多肽的核酸,其中所述多肽包含(i)来源于vegfr-1的第一结构域;(ii)来源于vegfr-2的第二结构域;和(iii)能够结合至血管生成素(例如,血管生成素1和血管生成素2)的第三结构域;和(b)下列的衣壳蛋白:aav1、aav2、aav2i8、aav3、aav3-b、aav4、aav5、aav6、aav7、aav8、aavrh8、aavrh8r、aav9、aav10、aavrh10、aav11、aav12、aav13、aav-dj、aav lk03、aavrh74、aav44-9或其变体。在一些实施方式中,第三结构域处于第一结构域和第二结构域的n-末端。在一些实施方式中,所述衣壳蛋白是aav2衣壳蛋白。在一些实施方式中,所述衣壳蛋白是aav8衣壳蛋白。在一些实施方式中,所述衣壳蛋白是包含seq id no:48所示的氨基酸序列的aav2衣壳蛋白的变体,其中所述变体包含aav2的衣壳蛋白vpl的氨基酸替换y444f、r487g、t491v、y500f、r585s、r588t和y730f。
31、在另一个方面,本文提供了重组aav(raav)颗粒,其包含(a)编码多肽的核酸,其中所述多肽包含(i)来源于vegfr-1的第一结构域;(ii)来源于vegfr-2的第二结构域;和(iii)能够结合至血管生成素的第三结构域;和(iv)能够结合至vegfc的第四结构域;和(b)下列的衣壳蛋白:aav1、aav2、aav2i8、aav3、aav3-b、aav4、aav5、aav6、aav7、aav8、aavrh8、aavrh8r、aav9、aav10、aavrh10、aav11、aav12、aav13、aav-dj、aav lk03、aavrh74、aav44-9或其变体。
32、药物组合物,其包含本文所提供的多肽、载体或raav载体或者raav颗粒和药学上可接受的赋形剂。
33、在另一个方面,本文提供了治疗受试者中疾病或病症的方法,其包括向所述受试者施用本文所提供的多肽、载体或药物组合物。在一些实施方式中,所述疾病或病症是血管生成或新生血管疾病或病症。在一些实施方式中,所述疾病或病症是炎性疾病、眼部疾病、自体免疫疾病或癌症。在一些实施方式中,所述疾病或病症是眼部疾病或病症。在一些实施方式中,所述眼部疾病或病症选自葡萄膜炎、色素性视网膜炎、新生血管型青光眼、糖尿病性视网膜病(dr)(包括增殖性糖尿病性视网膜病)、缺血性视网膜病、眼内新血管形成、年龄相关性黄斑变性(amd)、视网膜新血管形成、糖尿病性黄斑水肿(dme)、糖尿病性视网膜缺血、糖尿病性视网膜水肿、视网膜静脉阻塞(包括视网膜中央静脉阻塞和视网膜分支静脉阻塞)、黄斑水肿和视网膜静脉阻塞(rvo)后黄斑水肿。在一些实施方式中,所述疾病或病症是年龄相关性黄斑变性(amd)。在一些实施方式中,所述amd是湿性amd(wamd)。
34、在一些实施方式中,所述方法包括通过向受试者眼部玻璃体内或视网膜下注射的施用。
35、 序列表
36、<110> 杭州嘉因生物科技有限公司
37、<120> 靶向vegf和血管生成素的融合分子及其用途
38、<130> 14652-025-228
39、<140>
40、<141>
41、<150> pct/cn2021/084559
42、<151> 2021-03-31
43、<160> 75
44、<170> patentin version 3.5
45、<210> 1
46、<211> 103
47、<212> prt
48、<213> 人工序列
49、<220>
50、<223> 来源vegfr-1(d2)的示例性第一结构域
51、<400> 1
52、ser asp thr gly arg pro phe val glu met tyr ser glu ile pro glu
53、1 5 10 15
54、ile ile his met thr glu gly arg glu leu val ile pro cys arg val
55、 20 25 30
56、thr ser pro asn ile thr val thr leu lys lys phe pro leu asp thr
57、 35 40 45
58、leu ile pro asp gly lys arg ile ile trp asp ser arg lys gly phe
59、 50 55 60
60、ile ile ser asn ala thr tyr lys glu ile gly leu leu thr cys glu
61、65 70 75 80
62、ala thr val asn gly his leu tyr lys thr asn tyr leu thr his arg
63、 85 90 95
64、gln thr asn thr ile ile asp
65、 100
66、<210> 2
67、<211> 101
68、<212> prt
69、<213> 人工序列
70、<220>
71、<223> 来源于vegfr-2(d3)的示例性第二结构域
72、<400> 2
73、val val leu ser pro ser his gly ile glu leu ser val gly glu lys
74、1 5 10 15
75、leu val leu asn cys thr ala arg thr glu leu asn val gly ile asp
76、 20 25 30
77、phe asn trp glu tyr pro ser ser lys his gln his lys lys leu val
78、 35 40 45
79、asn arg asp leu lys thr gln ser gly ser glu met lys lys phe leu
80、 50 55 60
81、ser thr leu thr ile asp gly val thr arg ser asp gln gly leu tyr
82、65 70 75 80
83、thr cys ala ala ser ser gly leu met thr lys lys asn ser thr phe
84、 85 90 95
85、val arg val his glu
86、 100
87、<210> 3
88、<211> 14
89、<212> prt
90、<213> 人工序列
91、<220>
92、<223> 示例性第三结构域(abd)中的14个氨基酸的序列,abd
93、 (con4)
94、<400> 3
95、gln glu glu cys glu trp asp pro trp thr cys glu his met
96、1 5 10
97、<210> 4
98、<211> 59
99、<212> prt
100、<213> 人工序列
101、<220>
102、<223> 示例性第三结构域(abd),abd(1)(2xcon4)
103、<400> 4
104、gly gly gly gly gly ala gln gln glu glu cys glu trp asp pro trp
105、1 5 10 15
106、thr cys glu his met gly ser gly ser ala thr gly gly ser gly ser
107、 20 25 30
108、thr ala ser ser gly ser gly ser ala thr his gln glu glu cys glu
109、 35 40 45
110、trp asp pro trp thr cys glu his met leu glu
111、 50 55
112、<210> 5
113、<211> 227
114、<212> prt
115、<213> 人工序列
116、<220>
117、<223> 示例性igg-fc(1)
118、<400> 5
119、asp lys thr his thr cys pro pro cys pro ala pro glu leu leu gly
120、1 5 10 15
121、gly pro ser val phe leu phe pro pro lys pro lys asp thr leu met
122、 20 25 30
123、ile ser arg thr pro glu val thr cys val val val asp val ser his
124、 35 40 45
125、glu asp pro glu val lys phe asn trp tyr val asp gly val glu val
126、 50 55 60
127、his asn ala lys thr lys pro arg glu glu gln tyr asn ser thr tyr
128、65 70 75 80
129、arg val val ser val leu thr val leu his gln asp trp leu asn gly
130、 85 90 95
131、lys glu tyr lys cys lys val ser asn lys ala leu pro ala pro ile
132、 100 105 110
133、glu lys thr ile ser lys ala lys gly gln pro arg glu pro gln val
134、 115 120 125
135、tyr thr leu pro pro ser arg asp glu leu thr lys asn gln val ser
136、 130 135 140
137、leu thr cys leu val lys gly phe tyr pro ser asp ile ala val glu
138、145 150 155 160
139、trp glu ser asn gly gln pro glu asn asn tyr lys thr thr pro pro
140、 165 170 175
141、val leu asp ser asp gly ser phe phe leu tyr ser lys leu thr val
142、 180 185 190
143、asp lys ser arg trp gln gln gly asn val phe ser cys ser val met
144、 195 200 205
145、his glu ala leu his asn his tyr thr gln lys ser leu ser leu ser
146、 210 215 220
147、pro gly lys
148、225
149、<210> 6
150、<211> 26
151、<212> prt
152、<213> 人工序列
153、<220>
154、<223> flt-1信号
155、<400> 6
156、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
157、1 5 10 15
158、cys leu leu leu thr gly ser ser ser gly
159、 20 25
160、<210> 7
161、<211> 517
162、<212> prt
163、<213> 人工序列
164、<220>
165、<223> 示例性多肽1
166、<400> 7
167、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
168、1 5 10 15
169、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
170、 20 25 30
171、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
172、 35 40 45
173、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
174、 50 55 60
175、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
176、65 70 75 80
177、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
178、 85 90 95
179、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
180、 100 105 110
181、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
182、 115 120 125
183、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
184、 130 135 140
185、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
186、145 150 155 160
187、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
188、 165 170 175
189、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
190、 180 185 190
191、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
192、 195 200 205
193、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
194、 210 215 220
195、phe val arg val his glu lys asp lys thr his thr cys pro pro cys
196、225 230 235 240
197、pro ala pro glu leu leu gly gly pro ser val phe leu phe pro pro
198、 245 250 255
199、lys pro lys asp thr leu met ile ser arg thr pro glu val thr cys
200、 260 265 270
201、val val val asp val ser his glu asp pro glu val lys phe asn trp
202、 275 280 285
203、tyr val asp gly val glu val his asn ala lys thr lys pro arg glu
204、 290 295 300
205、glu gln tyr asn ser thr tyr arg val val ser val leu thr val leu
206、305 310 315 320
207、his gln asp trp leu asn gly lys glu tyr lys cys lys val ser asn
208、 325 330 335
209、lys ala leu pro ala pro ile glu lys thr ile ser lys ala lys gly
210、 340 345 350
211、gln pro arg glu pro gln val tyr thr leu pro pro ser arg asp glu
212、 355 360 365
213、leu thr lys asn gln val ser leu thr cys leu val lys gly phe tyr
214、 370 375 380
215、pro ser asp ile ala val glu trp glu ser asn gly gln pro glu asn
216、385 390 395 400
217、asn tyr lys thr thr pro pro val leu asp ser asp gly ser phe phe
218、 405 410 415
219、leu tyr ser lys leu thr val asp lys ser arg trp gln gln gly asn
220、 420 425 430
221、val phe ser cys ser val met his glu ala leu his asn his tyr thr
222、 435 440 445
223、gln lys ser leu ser leu ser pro gly lys gly gly gly gly gly ala
224、 450 455 460
225、gln gln glu glu cys glu trp asp pro trp thr cys glu his met gly
226、465 470 475 480
227、ser gly ser ala thr gly gly ser gly ser thr ala ser ser gly ser
228、 485 490 495
229、gly ser ala thr his gln glu glu cys glu trp asp pro trp thr cys
230、 500 505 510
231、glu his met leu glu
232、 515
233、<210> 8
234、<211> 523
235、<212> prt
236、<213> 人工序列
237、<220>
238、<223> 示例性多肽2
239、<400> 8
240、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
241、1 5 10 15
242、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
243、 20 25 30
244、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
245、 35 40 45
246、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
247、 50 55 60
248、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
249、65 70 75 80
250、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
251、 85 90 95
252、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
253、 100 105 110
254、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
255、 115 120 125
256、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
257、 130 135 140
258、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
259、145 150 155 160
260、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
261、 165 170 175
262、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
263、 180 185 190
264、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
265、 195 200 205
266、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
267、 210 215 220
268、phe val arg val his glu lys gly gly gly gly gly ser gly gly gly
269、225 230 235 240
270、gly gly ala gln gln glu glu cys glu trp asp pro trp thr cys glu
271、 245 250 255
272、his met gly ser gly ser ala thr gly gly ser gly ser thr ala ser
273、 260 265 270
274、ser gly ser gly ser ala thr his gln glu glu cys glu trp asp pro
275、 275 280 285
276、trp thr cys glu his met leu glu asp lys thr his thr cys pro pro
277、 290 295 300
278、cys pro ala pro glu leu leu gly gly pro ser val phe leu phe pro
279、305 310 315 320
280、pro lys pro lys asp thr leu met ile ser arg thr pro glu val thr
281、 325 330 335
282、cys val val val asp val ser his glu asp pro glu val lys phe asn
283、 340 345 350
284、trp tyr val asp gly val glu val his asn ala lys thr lys pro arg
285、 355 360 365
286、glu glu gln tyr asn ser thr tyr arg val val ser val leu thr val
287、 370 375 380
288、leu his gln asp trp leu asn gly lys glu tyr lys cys lys val ser
289、385 390 395 400
290、asn lys ala leu pro ala pro ile glu lys thr ile ser lys ala lys
291、 405 410 415
292、gly gln pro arg glu pro gln val tyr thr leu pro pro ser arg asp
293、 420 425 430
294、glu leu thr lys asn gln val ser leu thr cys leu val lys gly phe
295、 435 440 445
296、tyr pro ser asp ile ala val glu trp glu ser asn gly gln pro glu
297、 450 455 460
298、asn asn tyr lys thr thr pro pro val leu asp ser asp gly ser phe
299、465 470 475 480
300、phe leu tyr ser lys leu thr val asp lys ser arg trp gln gln gly
301、 485 490 495
302、asn val phe ser cys ser val met his glu ala leu his asn his tyr
303、 500 505 510
304、thr gln lys ser leu ser leu ser pro gly lys
305、 515 520
306、<210> 9
307、<211> 529
308、<212> prt
309、<213> 人工序列
310、<220>
311、<223> 示例性多肽3
312、<400> 9
313、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
314、1 5 10 15
315、cys leu leu leu thr gly ser ser ser gly gly gly gly gly gly ser
316、 20 25 30
317、gly gly gly gly gly ala gln gln glu glu cys glu trp asp pro trp
318、 35 40 45
319、thr cys glu his met gly ser gly ser ala thr gly gly ser gly ser
320、 50 55 60
321、thr ala ser ser gly ser gly ser ala thr his gln glu glu cys glu
322、65 70 75 80
323、trp asp pro trp thr cys glu his met leu glu gly gly gly gly gly
324、 85 90 95
325、ser ser asp thr gly arg pro phe val glu met tyr ser glu ile pro
326、 100 105 110
327、glu ile ile his met thr glu gly arg glu leu val ile pro cys arg
328、 115 120 125
329、val thr ser pro asn ile thr val thr leu lys lys phe pro leu asp
330、 130 135 140
331、thr leu ile pro asp gly lys arg ile ile trp asp ser arg lys gly
332、145 150 155 160
333、phe ile ile ser asn ala thr tyr lys glu ile gly leu leu thr cys
334、 165 170 175
335、glu ala thr val asn gly his leu tyr lys thr asn tyr leu thr his
336、 180 185 190
337、arg gln thr asn thr ile ile asp val val leu ser pro ser his gly
338、 195 200 205
339、ile glu leu ser val gly glu lys leu val leu asn cys thr ala arg
340、 210 215 220
341、thr glu leu asn val gly ile asp phe asn trp glu tyr pro ser ser
342、225 230 235 240
343、lys his gln his lys lys leu val asn arg asp leu lys thr gln ser
344、 245 250 255
345、gly ser glu met lys lys phe leu ser thr leu thr ile asp gly val
346、 260 265 270
347、thr arg ser asp gln gly leu tyr thr cys ala ala ser ser gly leu
348、 275 280 285
349、met thr lys lys asn ser thr phe val arg val his glu lys asp lys
350、 290 295 300
351、thr his thr cys pro pro cys pro ala pro glu leu leu gly gly pro
352、305 310 315 320
353、ser val phe leu phe pro pro lys pro lys asp thr leu met ile ser
354、 325 330 335
355、arg thr pro glu val thr cys val val val asp val ser his glu asp
356、 340 345 350
357、pro glu val lys phe asn trp tyr val asp gly val glu val his asn
358、 355 360 365
359、ala lys thr lys pro arg glu glu gln tyr asn ser thr tyr arg val
360、 370 375 380
361、val ser val leu thr val leu his gln asp trp leu asn gly lys glu
362、385 390 395 400
363、tyr lys cys lys val ser asn lys ala leu pro ala pro ile glu lys
364、 405 410 415
365、thr ile ser lys ala lys gly gln pro arg glu pro gln val tyr thr
366、 420 425 430
367、leu pro pro ser arg asp glu leu thr lys asn gln val ser leu thr
368、 435 440 445
369、cys leu val lys gly phe tyr pro ser asp ile ala val glu trp glu
370、 450 455 460
371、ser asn gly gln pro glu asn asn tyr lys thr thr pro pro val leu
372、465 470 475 480
373、asp ser asp gly ser phe phe leu tyr ser lys leu thr val asp lys
374、 485 490 495
375、ser arg trp gln gln gly asn val phe ser cys ser val met his glu
376、 500 505 510
377、ala leu his asn his tyr thr gln lys ser leu ser leu ser pro gly
378、 515 520 525
379、lys
380、<210> 10
381、<211> 316
382、<212> prt
383、<213> 人工序列
384、<220>
385、<223> 示例性多肽4
386、<400> 10
387、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
388、1 5 10 15
389、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
390、 20 25 30
391、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
392、 35 40 45
393、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
394、 50 55 60
395、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
396、65 70 75 80
397、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
398、 85 90 95
399、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
400、 100 105 110
401、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
402、 115 120 125
403、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
404、 130 135 140
405、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
406、145 150 155 160
407、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
408、 165 170 175
409、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
410、 180 185 190
411、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
412、 195 200 205
413、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
414、 210 215 220
415、phe val arg val his glu lys asp lys thr his thr cys pro pro cys
416、225 230 235 240
417、pro ala pro glu leu leu gly gly pro ser val gly gly gly gly gly
418、 245 250 255
419、ser gly gly gly gly gly ala gln gln glu glu cys glu trp asp pro
420、 260 265 270
421、trp thr cys glu his met gly ser gly ser ala thr gly gly ser gly
422、 275 280 285
423、ser thr ala ser ser gly ser gly ser ala thr his gln glu glu cys
424、 290 295 300
425、glu trp asp pro trp thr cys glu his met leu glu
426、305 310 315
427、<210> 11
428、<211> 3672
429、<212> dna
430、<213> 人工序列
431、<220>
432、<223> exg102-02
433、<400> 11
434、ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60
435、cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 120
436、gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa 180
437、tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg 240
438、gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg 300
439、tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta 360
440、cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt 420
441、gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac 480
442、tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc 540
443、cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta 600
444、tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca 660
445、ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc 720
446、aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc 780
447、tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc 840
448、cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag 900
449、gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg 960
450、cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc 1020
451、ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc 1080
452、tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc 1140
453、agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag 1200
454、gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg 1260
455、tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct 1320
456、tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg 1380
457、cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag 1440
458、gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc 1500
459、cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag 1560
460、ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc 1620
461、gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt 1680
462、ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc 1740
463、agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt 1800
464、catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat 1860
465、cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccaccat 1920
466、ggtgtcttat tgggatactg gcgtgctgct ctgtgccctc ctgagttgcc tgctcctgac 1980
467、tggttcttct tctgggtccg atactgggcg ccccttcgtg gagatgtact ccgagatccc 2040
468、tgaaatcatt cacatgactg agggtcggga actggtcatc ccatgccgcg tgacctctcc 2100
469、caacattact gtgaccctga agaaattccc tctggacacc ctcatcccag atgggaagag 2160
470、gatcatttgg gactcaagaa agggttttat catcagcaac gctacataca aggagattgg 2220
471、cctgctcacc tgcgaagcaa cagtgaacgg acacctgtac aagactaatt atctcaccca 2280
472、tagacagaca aacactatca ttgatgtggt cctgtcacca agccacggca tcgagctcag 2340
473、cgtcggtgaa aagctggtgc tcaattgtac agcccggact gagctgaacg tgggcattga 2400
474、cttcaattgg gaatacccca gctccaagca ccagcataag aaactggtga accgcgatct 2460
475、caaaacccag tccggatctg agatgaagaa atttctgagc accctcacaa tcgacggcgt 2520
476、gacacgatcc gatcagggac tgtatacttg cgccgcttct agtggcctga tgaccaagaa 2580
477、aaatagcaca ttcgtcaggg tgcacgaaaa ggacaaaact catacctgcc caccttgtcc 2640
478、agcaccagag ctgctcggag gaccatccgt gttcctgttt ccacccaagc ccaaagatac 2700
479、tctgatgatt tcacgcacac ccgaagtcac ttgcgtggtc gtggacgtgt cccacgagga 2760
480、ccccgaagtc aagtttaact ggtacgtgga cggcgtcgag gtgcataatg ctaagacaaa 2820
481、accccgagag gaacagtaca actctaccta tagggtcgtg agtgtcctga cagtgctcca 2880
482、ccaggattgg ctgaacggaa aggagtataa gtgcaaagtg tctaataagg cactgcctgc 2940
483、cccaatcgag aaaacaatta gtaaggccaa agggcagccc agagaacctc aggtgtacac 3000
484、tctgcctcca tctcgggacg agctcactaa gaaccaggtc agtctgacct gtctcgtgaa 3060
485、agggttctat cctagtgata tcgctgtgga gtgggaatca aatggtcagc cagagaacaa 3120
486、ttacaagacc acaccccctg tcctggacag cgatggctcc ttctttctgt attccaagct 3180
487、caccgtggac aaatctcgat ggcagcaggg aaacgtcttt agttgttcag tgatgcacga 3240
488、agccctccat aaccactaca ctcagaaaag cctcagcctc agccctggga aatgataagc 3300
489、ggccgcgcgg atccagacat gataagatac attgatgagt ttggacaaac cacaactaga 3360
490、atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc 3420
491、attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt 3480
492、cagggggagg tgtgggaggt tttttagtcg actggggaga gatctgagga acccctagtg 3540
493、atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag 3600
494、cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag 3660
495、ggagtggcca ac 3672
496、<210> 12
497、<211> 4348
498、<212> dna
499、<213> 人工序列
500、<220>
501、<223> exg102-03-01
502、<400> 12
503、ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60
504、cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 120
505、gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa 180
506、tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg 240
507、gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg 300
508、tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta 360
509、cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt 420
510、gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac 480
511、tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc 540
512、cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta 600
513、tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca 660
514、ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc 720
515、aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc 780
516、tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc 840
517、cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag 900
518、gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg 960
519、cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc 1020
520、ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc 1080
521、tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc 1140
522、agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag 1200
523、gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg 1260
524、tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct 1320
525、tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg 1380
526、cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag 1440
527、gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc 1500
528、cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag 1560
529、ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc 1620
530、gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt 1680
531、ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc 1740
532、agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt 1800
533、catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat 1860
534、cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgagagaa ttcgccacca 1920
535、tggtgagcta ttgggataca ggcgtgctgc tgtgcgccct gctgagctgc ctgctgctga 1980
536、ccggcagcag cagcggcagc gacaccggca gacctttcgt ggagatgtac agcgagatcc 2040
537、ctgagatcat ccacatgacc gagggcagag agctggtgat cccttgcaga gtgaccagcc 2100
538、ctaatatcac cgtgaccctc aagaagttcc ctctggatac cctgatccct gacggcaaga 2160
539、gaatcatctg ggacagcaga aagggcttca tcatcagcaa tgccacctac aaggagatcg 2220
540、gcctgctgac ctgcgaggcc accgtgaatg gccacctgta caagaccaat tacctgaccc 2280
541、acagacagac caataccatc atcgacgtgg tgctgagccc tagccacggc atcgagctga 2340
542、gcgtgggcga gaagctggtg ctgaattgca ccgccagaac cgagctgaat gtgggcatcg 2400
543、acttcaattg ggagtaccct agcagcaagc accagcacaa gaagctggtg aatagagacc 2460
544、tgaagaccca gagcggcagc gagatgaaga aattcctgag caccctgacc atcgacggcg 2520
545、tgaccagaag cgaccagggc ctgtacacct gcgctgccag cagcggcctg atgaccaaga 2580
546、agaatagcac cttcgtgaga gtgcacgaga aggacaagac ccacacctgc cctccttgcc 2640
547、ctgcccctga gctgctgggc ggccctagcg tgttcctgtt ccctcctaag cctaaggaca 2700
548、ccctcatgat cagcagaacc cctgaggtga cctgcgtggt ggtggacgtg agccacgagg 2760
549、accctgaggt gaagttcaat tggtacgtgg acggcgtgga ggtgcacaat gccaagacca 2820
550、agcctagaga ggagcagtac aatagcacct acagagtggt gagcgtgctg accgtgctgc 2880
551、accaggactg gctgaatggc aaggagtaca agtgcaaggt gagcaataag gccctgcctg 2940
552、cccctatcga gaagaccatc agcaaggcca agggccagcc tagagagcct caggtgtaca 3000
553、ccctgcctcc tagcagagac gagctgacca agaatcaggt gagcctgacc tgcctggtga 3060
554、agggcttcta ccctagcgac atcgccgtgg agtgggagag caatggccag cctgagaata 3120
555、attacaagac cacccctcct gtgctggaca gcgacggcag cttcttcctg tacagcaagc 3180
556、tgaccgtgga caagagcaga tggcagcagg gcaatgtgtt cagctgcagc gtgatgcacg 3240
557、aggccctgca caatcactac acacagaaga gcctgagcct gagccctggc aagtgataag 3300
558、gatatcaaga tcttgcggcc gctcgataat caacctctgg attacaaaat ttgtgaaaga 3360
559、ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg 3420
560、cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc 3480
561、tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc 3540
562、actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt 3600
563、tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt 3660
564、gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg 3720
565、aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg 3780
566、tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg 3840
567、ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt 3900
568、tgggccgcct ccccgcatcg ataccgtcga ggaagcttaa gctagagctc gctgatcagc 3960
569、ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt 4020
570、gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca 4080
571、ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga 4140
572、ggattgggaa gacaatagca ggcatgctgg ggagagtcta gagtcgactg gggagagatc 4200
573、tgaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga 4260
574、ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga 4320
575、gcgagcgcgc agagagggag tggccaac 4348
576、<210> 13
577、<211> 4348
578、<212> dna
579、<213> 人工序列
580、<220>
581、<223> exg102-03-2
582、<400> 13
583、ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60
584、cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 120
585、gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa 180
586、tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg 240
587、gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg 300
588、tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta 360
589、cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt 420
590、gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac 480
591、tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc 540
592、cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta 600
593、tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca 660
594、ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc 720
595、aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc 780
596、tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc 840
597、cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag 900
598、gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg 960
599、cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc 1020
600、ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc 1080
601、tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc 1140
602、agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag 1200
603、gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg 1260
604、tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct 1320
605、tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg 1380
606、cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag 1440
607、gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc 1500
608、cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag 1560
609、ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc 1620
610、gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt 1680
611、ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc 1740
612、agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt 1800
613、catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat 1860
614、cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgagagaa ttcgccacca 1920
615、tggtgagcta ttgggataca ggcgtgctgc tgtgcgccct gctgagctgc ctgctgctga 1980
616、ccggcagcag cagcggcagc gacaccggca gacctttcgt ggagatgtac agcgagatcc 2040
617、ctgagatcat ccacatgacc gagggcagag agctggtgat cccttgcaga gtgaccagcc 2100
618、ctaatatcac cgtgaccctc aagaagttcc ctctggatac cctgatccct gacggcaaga 2160
619、gaatcatctg ggacagcaga aagggcttca tcatcagcaa tgccacctac aaggagatcg 2220
620、gcctgctgac ctgcgaggcc accgtgaatg gccacctgta caagaccaat tacctgaccc 2280
621、acagacagac caataccatc atcgacgtgg tgctgagccc tagccacggc atcgagctga 2340
622、gcgtgggcga gaagctggtg ctgaattgca ccgccagaac cgagctgaat gtgggcatcg 2400
623、acttcaattg ggagtaccct agcagcaagc accagcacaa gaagctggtg aatagagacc 2460
624、tgaagaccca gagcggcagc gagatgaaga aattcctgag caccctgacc atcgacggcg 2520
625、tgaccagaag cgaccagggc ctgtacacct gcgctgccag cagcggcctg atgaccaaga 2580
626、agaatagcac cttcgtgaga gtgcacgaga aggacaagac ccacacctgc cctccttgcc 2640
627、ctgcccctga gctgctgggc ggccctagcg tgttcctgtt ccctcctaag cctaaggaca 2700
628、ccctcatgat cagcagaacc cctgaggtga cctgcgtggt ggtggacgtg agccacgagg 2760
629、accctgaggt gaagttcaat tggtacgtgg acggcgtgga ggtgcacaat gccaagacca 2820
630、agcctagaga ggagcagtac aatagcacct acagagtggt gagcgtgctg accgtgctgc 2880
631、accaggactg gctgaatggc aaggagtaca agtgcaaggt gagcaataag gccctgcctg 2940
632、cccctatcga gaagaccatc agcaaggcca agggccagcc tagagagcct caggtgtaca 3000
633、ccctgcctcc tagcagagac gagctgacca agaatcaggt gagcctgacc tgcctggtga 3060
634、agggcttcta ccctagcgac atcgccgtgg agtgggagag caatggccag cctgagaata 3120
635、attacaagac cacccctcct gtgctggaca gcgacggcag cttcttcctg tacagcaagc 3180
636、tgaccgtgga caagagcaga tggcagcagg gcaatgtgtt cagctgcagc gtgatgcacg 3240
637、aggccctgca caatcactac acacagaaga gcctgagcct gagccctggc aagtgataag 3300
638、gatatcaaga tcttgcggcc gctcgataat caacctctgg attacaaaat ttgtgaaaga 3360
639、ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg 3420
640、cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc 3480
641、tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc 3540
642、actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt 3600
643、tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt 3660
644、gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg 3720
645、aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg 3780
646、tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg 3840
647、ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt 3900
648、tgggccgcct ccccgcatcg ataccgtcga ggaagcttaa gctagagctc gctgatcagc 3960
649、ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt 4020
650、gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca 4080
651、ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga 4140
652、ggattgggaa gacaatagca ggcatgctgg ggagagtcta gagtcgactg gggagagatc 4200
653、tgaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga 4260
654、ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga 4320
655、gcgagcgcgc agagagggag tggccaac 4348
656、<210> 14
657、<211> 2755
658、<212> dna
659、<213> 人工序列
660、<220>
661、<223> exg102-04
662、<400> 14
663、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
664、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
665、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
666、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
667、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
668、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
669、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
670、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
671、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
672、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
673、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
674、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
675、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
676、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
677、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
678、aagctgcgga attgtacccg cggccgatcc accggtccgg aattcgccac catggtgtct 960
679、tattgggata ctggcgtgct gctctgtgcc ctcctgagtt gcctgctcct gactggttct 1020
680、tcttctgggt ccgatactgg gcgccccttc gtggagatgt actccgagat ccctgaaatc 1080
681、attcacatga ctgagggtcg ggaactggtc atcccatgcc gcgtgacctc tcccaacatt 1140
682、actgtgaccc tgaagaaatt ccctctggac accctcatcc cagatgggaa gaggatcatt 1200
683、tgggactcaa gaaagggttt tatcatcagc aacgctacat acaaggagat tggcctgctc 1260
684、acctgcgaag caacagtgaa cggacacctg tacaagacta attatctcac ccatagacag 1320
685、acaaacacta tcattgatgt ggtcctgtca ccaagccacg gcatcgagct cagcgtcggt 1380
686、gaaaagctgg tgctcaattg tacagcccgg actgagctga acgtgggcat tgacttcaat 1440
687、tgggaatacc ccagctccaa gcaccagcat aagaaactgg tgaaccgcga tctcaaaacc 1500
688、cagtccggat ctgagatgaa gaaatttctg agcaccctca caatcgacgg cgtgacacga 1560
689、tccgatcagg gactgtatac ttgcgccgct tctagtggcc tgatgaccaa gaaaaatagc 1620
690、acattcgtca gggtgcacga aaaggacaaa actcatacct gcccaccttg tccagcacca 1680
691、gagctgctcg gaggaccatc cgtgttcctg tttccaccca agcccaaaga tactctgatg 1740
692、atttcacgca cacccgaagt cacttgcgtg gtcgtggacg tgtcccacga ggaccccgaa 1800
693、gtcaagttta actggtacgt ggacggcgtc gaggtgcata atgctaagac aaaaccccga 1860
694、gaggaacagt acaactctac ctatagggtc gtgagtgtcc tgacagtgct ccaccaggat 1920
695、tggctgaacg gaaaggagta taagtgcaaa gtgtctaata aggcactgcc tgccccaatc 1980
696、gagaaaacaa ttagtaaggc caaagggcag cccagagaac ctcaggtgta cactctgcct 2040
697、ccatctcggg acgagctcac taagaaccag gtcagtctga cctgtctcgt gaaagggttc 2100
698、tatcctagtg atatcgctgt ggagtgggaa tcaaatggtc agccagagaa caattacaag 2160
699、accacacccc ctgtcctgga cagcgatggc tccttctttc tgtattccaa gctcaccgtg 2220
700、gacaaatctc gatggcagca gggaaacgtc tttagttgtt cagtgatgca cgaagccctc 2280
701、cataaccact acactcagaa aagcctcagc ctcagccctg ggaaatgata aggatatcaa 2340
702、gatctacaaa gcttatcgat accgtcgact agagctcgct gatcagcctc gactgtgcct 2400
703、tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt 2460
704、gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg 2520
705、tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagtc 2580
706、tagagcaggc atgctgggga gagatcgatc tgaggaaccc ctagtgatgg agttggccac 2640
707、tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc 2700
708、gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagagggag tggcc 2755
709、<210> 15
710、<211> 2755
711、<212> dna
712、<213> 人工序列
713、<220>
714、<223> exg102-05
715、<400> 15
716、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
717、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
718、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
719、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
720、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
721、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
722、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
723、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
724、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
725、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
726、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
727、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
728、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
729、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
730、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
731、aagctgcgga attgtacccg cggccgatcc accggtccgg aattcgccac catggtgtct 960
732、tattgggata ctggcgtgct gctctgtgcc ctcctgagtt gcctgctcct gactggttct 1020
733、tcttctgggt ccgatactgg gcgccccttc gtggagatgt actccgagat ccctgaaatc 1080
734、attcacatga ctgagggtcg ggaactggtc atcccatgcc gcgtgacctc tcccaacatt 1140
735、actgtgaccc tgaagaaatt ccctctggac accctcatcc cagatgggaa gaggatcatt 1200
736、tgggactcaa gaaagggttt tatcatcagc aacgctacat acaaggagat tggcctgctc 1260
737、acctgcgaag caacagtgaa cggacacctg tacaagacta attatctcac ccatagacag 1320
738、acaaacacta tcattgatgt ggtcctgtca ccaagccacg gcatcgagct cagcgtcggt 1380
739、gaaaagctgg tgctcaattg tacagcccgg actgagctga acgtgggcat tgacttcaat 1440
740、tgggaatacc ccagctccaa gcaccagcat aagaaactgg tgaaccgcga tctcaaaacc 1500
741、cagtccggat ctgagatgaa gaaatttctg agcaccctca caatcgacgg cgtgacacga 1560
742、tccgatcagg gactgtatac ttgcgccgct tctagtggcc tgatgaccaa gaaaaatagc 1620
743、acattcgtca gggtgcacga aaaggacaaa actcatacct gcccaccttg tccagcacca 1680
744、gagctgctcg gaggaccatc cgtgttcctg tttccaccca agcccaaaga tactctgatg 1740
745、atttcacgca cacccgaagt cacttgcgtg gtcgtggacg tgtcccacga ggaccccgaa 1800
746、gtcaagttta actggtacgt ggacggcgtc gaggtgcata atgctaagac aaaaccccga 1860
747、gaggaacagt acaactctac ctatagggtc gtgagtgtcc tgacagtgct ccaccaggat 1920
748、tggctgaacg gaaaggagta taagtgcaaa gtgtctaata aggcactgcc tgccccaatc 1980
749、gagaaaacaa ttagtaaggc caaagggcag cccagagaac ctcaggtgta cactctgcct 2040
750、ccatctcggg acgagctcac taagaaccag gtcagtctga cctgtctcgt gaaagggttc 2100
751、tatcctagtg atatcgctgt ggagtgggaa tcaaatggtc agccagagaa caattacaag 2160
752、accacacccc ctgtcctgga cagcgatggc tccttctttc tgtattccaa gctcaccgtg 2220
753、gacaaatctc gatggcagca gggaaacgtc tttagttgtt cagtgatgca cgaagccctc 2280
754、cataaccact acactcagaa aagcctcagc ctcagccctg ggaaatgata aggatatcaa 2340
755、gatctacaaa gcttatcgat accgtcgact agagctcgct gatcagcctc gactgtgcct 2400
756、tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt 2460
757、gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg 2520
758、tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagtc 2580
759、tagagcaggc atgctgggga gagatcgatc tgaggaaccc ctagtgatgg agttggccac 2640
760、tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc 2700
761、gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagagggag tggcc 2755
762、<210> 16
763、<211> 3002
764、<212> dna
765、<213> 人工序列
766、<220>
767、<223> exg102-06
768、<400> 16
769、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
770、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
771、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
772、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
773、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
774、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
775、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
776、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
777、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
778、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
779、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
780、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
781、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
782、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
783、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
784、aagctgcgga attgtacccg cggccgatcc accggtccgg aattcgccac catggtgtct 960
785、tattgggata ctggcgtgct gctctgtgcc ctcctgagtt gcctgctcct gactggttct 1020
786、tcttctgggt ccgatactgg gcgccccttc gtggagatgt actccgagat ccctgaaatc 1080
787、attcacatga ctgagggtcg ggaactggtc atcccatgcc gcgtgacctc tcccaacatt 1140
788、actgtgaccc tgaagaaatt ccctctggac accctcatcc cagatgggaa gaggatcatt 1200
789、tgggactcaa gaaagggttt tatcatcagc aacgctacat acaaggagat tggcctgctc 1260
790、acctgcgaag caacagtgaa cggacacctg tacaagacta attatctcac ccatagacag 1320
791、acaaacacta tcattgatgt ggtcctgtca ccaagccacg gcatcgagct cagcgtcggt 1380
792、gaaaagctgg tgctcaattg tacagcccgg actgagctga acgtgggcat tgacttcaat 1440
793、tgggaatacc ccagctccaa gcaccagcat aagaaactgg tgaaccgcga tctcaaaacc 1500
794、cagtccggat ctgagatgaa gaaatttctg agcaccctca caatcgacgg cgtgacacga 1560
795、tccgatcagg gactgtatac ttgcgccgct tctagtggcc tgatgaccaa gaaaaatagc 1620
796、acattcgtca gggtgcacga aaaggacaaa actcatacct gcccaccttg tccagcacca 1680
797、gagctgctcg gaggaccatc cgtgttcctg tttccaccca agcccaaaga tactctgatg 1740
798、atttcacgca cacccgaagt cacttgcgtg gtcgtggacg tgtcccacga ggaccccgaa 1800
799、gtcaagttta actggtacgt ggacggcgtc gaggtgcata atgctaagac aaaaccccga 1860
800、gaggaacagt acaactctac ctatagggtc gtgagtgtcc tgacagtgct ccaccaggat 1920
801、tggctgaacg gaaaggagta taagtgcaaa gtgtctaata aggcactgcc tgccccaatc 1980
802、gagaaaacaa ttagtaaggc caaagggcag cccagagaac ctcaggtgta cactctgcct 2040
803、ccatctcggg acgagctcac taagaaccag gtcagtctga cctgtctcgt gaaagggttc 2100
804、tatcctagtg atatcgctgt ggagtgggaa tcaaatggtc agccagagaa caattacaag 2160
805、accacacccc ctgtcctgga cagcgatggc tccttctttc tgtattccaa gctcaccgtg 2220
806、gacaaatctc gatggcagca gggaaacgtc tttagttgtt cagtgatgca cgaagccctc 2280
807、cataaccact acactcagaa aagcctcagc ctcagccctg ggaaatgata aggatatcaa 2340
808、gatctataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta 2400
809、tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc 2460
810、ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttagttc ttgccacggc 2520
811、ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga 2580
812、caattccgtg gtgttaagct tatcgatacc gtcgactaga gctcgctgat cagcctcgac 2640
813、tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct 2700
814、ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct 2760
815、gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg 2820
816、ggaagtctag agcaggcatg ctggggagag atcgatctga ggaaccccta gtgatggagt 2880
817、tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc 2940
818、gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg 3000
819、cc 3002
820、<210> 17
821、<211> 3179
822、<212> dna
823、<213> 人工序列
824、<220>
825、<223> exg102-07
826、<400> 17
827、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
828、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
829、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
830、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
831、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
832、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
833、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
834、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
835、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
836、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
837、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
838、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
839、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
840、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
841、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
842、aagctgcgga attgtacccg cggccgatcc accggtccgg aattcgccac catggtgtct 960
843、tattgggata ctggcgtgct gctctgtgcc ctcctgagtt gcctgctcct gactggttct 1020
844、tcttctgggt ccgatactgg gcgccccttc gtggagatgt actccgagat ccctgaaatc 1080
845、attcacatga ctgagggtcg ggaactggtc atcccatgcc gcgtgacctc tcccaacatt 1140
846、actgtgaccc tgaagaaatt ccctctggac accctcatcc cagatgggaa gaggatcatt 1200
847、tgggactcaa gaaagggttt tatcatcagc aacgctacat acaaggagat tggcctgctc 1260
848、acctgcgaag caacagtgaa cggacacctg tacaagacta attatctcac ccatagacag 1320
849、acaaacacta tcattgatgt ggtcctgtca ccaagccacg gcatcgagct cagcgtcggt 1380
850、gaaaagctgg tgctcaattg tacagcccgg actgagctga acgtgggcat tgacttcaat 1440
851、tgggaatacc ccagctccaa gcaccagcat aagaaactgg tgaaccgcga tctcaaaacc 1500
852、cagtccggat ctgagatgaa gaaatttctg agcaccctca caatcgacgg cgtgacacga 1560
853、tccgatcagg gactgtatac ttgcgccgct tctagtggcc tgatgaccaa gaaaaatagc 1620
854、acattcgtca gggtgcacga aaaggacaaa actcatacct gcccaccttg tccagcacca 1680
855、gagctgctcg gaggaccatc cgtgttcctg tttccaccca agcccaaaga tactctgatg 1740
856、atttcacgca cacccgaagt cacttgcgtg gtcgtggacg tgtcccacga ggaccccgaa 1800
857、gtcaagttta actggtacgt ggacggcgtc gaggtgcata atgctaagac aaaaccccga 1860
858、gaggaacagt acaactctac ctatagggtc gtgagtgtcc tgacagtgct ccaccaggat 1920
859、tggctgaacg gaaaggagta taagtgcaaa gtgtctaata aggcactgcc tgccccaatc 1980
860、gagaaaacaa ttagtaaggc caaagggcag cccagagaac ctcaggtgta cactctgcct 2040
861、ccatctcggg acgagctcac taagaaccag gtcagtctga cctgtctcgt gaaagggttc 2100
862、tatcctagtg atatcgctgt ggagtgggaa tcaaatggtc agccagagaa caattacaag 2160
863、accacacccc ctgtcctgga cagcgatggc tccttctttc tgtattccaa gctcaccgtg 2220
864、gacaaatctc gatggcagca gggaaacgtc tttagttgtt cagtgatgca cgaagccctc 2280
865、cataaccact acactcagaa aagcctcagc ctcagccctg ggaaaggcgg cggcggaggc 2340
866、gcccagcaag aagagtgcga gtgggatccc tggacctgcg agcacatggg atccggcagc 2400
867、gccaccggag gatccggaag caccgcctcc agcggctccg gcagcgccac ccaccaggag 2460
868、gagtgtgagt gggacccctg gacctgcgaa cacatgctgg agtgataagg atatcaagat 2520
869、ctataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt 2580
870、tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc 2640
871、ccgtatggct ttcattttct cctccttgta taaatcctgg ttagttcttg ccacggcgga 2700
872、actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa 2760
873、ttccgtggtg ttaagcttat cgataccgtc gactagagct cgctgatcag cctcgactgt 2820
874、gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga 2880
875、aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag 2940
876、taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga 3000
877、agtctagagc aggcatgctg gggagagatc gatctgagga acccctagtg atggagttgg 3060
878、ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac 3120
879、gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag ggagtggcc 3179
880、<210> 18
881、<211> 2932
882、<212> dna
883、<213> 人工序列
884、<220>
885、<223> exg102-08
886、<400> 18
887、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
888、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
889、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
890、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
891、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
892、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
893、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
894、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
895、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
896、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
897、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
898、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
899、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
900、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
901、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
902、aagctgcgga attgtacccg cggccgatcc accggtccgg aattcgccac catggtgtct 960
903、tattgggata ctggcgtgct gctctgtgcc ctcctgagtt gcctgctcct gactggttct 1020
904、tcttctgggt ccgatactgg gcgccccttc gtggagatgt actccgagat ccctgaaatc 1080
905、attcacatga ctgagggtcg ggaactggtc atcccatgcc gcgtgacctc tcccaacatt 1140
906、actgtgaccc tgaagaaatt ccctctggac accctcatcc cagatgggaa gaggatcatt 1200
907、tgggactcaa gaaagggttt tatcatcagc aacgctacat acaaggagat tggcctgctc 1260
908、acctgcgaag caacagtgaa cggacacctg tacaagacta attatctcac ccatagacag 1320
909、acaaacacta tcattgatgt ggtcctgtca ccaagccacg gcatcgagct cagcgtcggt 1380
910、gaaaagctgg tgctcaattg tacagcccgg actgagctga acgtgggcat tgacttcaat 1440
911、tgggaatacc ccagctccaa gcaccagcat aagaaactgg tgaaccgcga tctcaaaacc 1500
912、cagtccggat ctgagatgaa gaaatttctg agcaccctca caatcgacgg cgtgacacga 1560
913、tccgatcagg gactgtatac ttgcgccgct tctagtggcc tgatgaccaa gaaaaatagc 1620
914、acattcgtca gggtgcacga aaaggacaaa actcatacct gcccaccttg tccagcacca 1680
915、gagctgctcg gaggaccatc cgtgttcctg tttccaccca agcccaaaga tactctgatg 1740
916、atttcacgca cacccgaagt cacttgcgtg gtcgtggacg tgtcccacga ggaccccgaa 1800
917、gtcaagttta actggtacgt ggacggcgtc gaggtgcata atgctaagac aaaaccccga 1860
918、gaggaacagt acaactctac ctatagggtc gtgagtgtcc tgacagtgct ccaccaggat 1920
919、tggctgaacg gaaaggagta taagtgcaaa gtgtctaata aggcactgcc tgccccaatc 1980
920、gagaaaacaa ttagtaaggc caaagggcag cccagagaac ctcaggtgta cactctgcct 2040
921、ccatctcggg acgagctcac taagaaccag gtcagtctga cctgtctcgt gaaagggttc 2100
922、tatcctagtg atatcgctgt ggagtgggaa tcaaatggtc agccagagaa caattacaag 2160
923、accacacccc ctgtcctgga cagcgatggc tccttctttc tgtattccaa gctcaccgtg 2220
924、gacaaatctc gatggcagca gggaaacgtc tttagttgtt cagtgatgca cgaagccctc 2280
925、cataaccact acactcagaa aagcctcagc ctcagccctg ggaaaggcgg cggcggaggc 2340
926、gcccagcaag aagagtgcga gtgggatccc tggacctgcg agcacatggg atccggcagc 2400
927、gccaccggag gatccggaag caccgcctcc agcggctccg gcagcgccac ccaccaggag 2460
928、gagtgtgagt gggacccctg gacctgcgaa cacatgctgg agtgataagg atatcaagat 2520
929、ctacaaagct tatcgatacc gtcgactaga gctcgctgat cagcctcgac tgtgccttct 2580
930、agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc 2640
931、actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt 2700
932、cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagtctag 2760
933、agcaggcatg ctggggagag atcgatctga ggaaccccta gtgatggagt tggccactcc 2820
934、ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg 2880
935、ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg cc 2932
936、<210> 19
937、<211> 3937
938、<212> dna
939、<213> 人工序列
940、<220>
941、<223> exg102-09
942、<400> 19
943、ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60
944、cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 120
945、gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa 180
946、tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg 240
947、gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg 300
948、tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta 360
949、cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt 420
950、gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac 480
951、tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc 540
952、cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta 600
953、tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca 660
954、ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc 720
955、aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc 780
956、tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc 840
957、cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag 900
958、gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg 960
959、cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc 1020
960、ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc 1080
961、tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc 1140
962、agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag 1200
963、gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg 1260
964、tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct 1320
965、tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg 1380
966、cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag 1440
967、gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc 1500
968、cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag 1560
969、ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc 1620
970、gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt 1680
971、ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc 1740
972、agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt 1800
973、catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat 1860
974、cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaacgcg tctcgagaga 1920
975、attcgccacc atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg 1980
976、cctgctcctg actggttctt cttctgggtc cgatactggg cgccccttcg tggagatgta 2040
977、ctccgagatc cctgaaatca ttcacatgac tgagggtcgg gaactggtca tcccatgccg 2100
978、cgtgacctct cccaacatta ctgtgaccct gaagaaattc cctctggaca ccctcatccc 2160
979、agatgggaag aggatcattt gggactcaag aaagggtttt atcatcagca acgctacata 2220
980、caaggagatt ggcctgctca cctgcgaagc aacagtgaac ggacacctgt acaagactaa 2280
981、ttatctcacc catagacaga caaacactat cattgatgtg gtcctgtcac caagccacgg 2340
982、catcgagctc agcgtcggtg aaaagctggt gctcaattgt acagcccgga ctgagctgaa 2400
983、cgtgggcatt gacttcaatt gggaataccc cagctccaag caccagcata agaaactggt 2460
984、gaaccgcgat ctcaaaaccc agtccggatc tgagatgaag aaatttctga gcaccctcac 2520
985、aatcgacggc gtgacacgat ccgatcaggg actgtatact tgcgccgctt ctagtggcct 2580
986、gatgaccaag aaaaatagca cattcgtcag ggtgcacgaa aagggcggcg gcggaggcag 2640
987、cggcggcggc ggaggcgccc agcaagaaga gtgcgagtgg gatccctgga cctgcgagca 2700
988、catgggatcc ggcagcgcca ccggaggatc cggaagcacc gcctccagcg gctccggcag 2760
989、cgccacccac caggaggagt gtgagtggga cccctggacc tgcgaacaca tgctggagga 2820
990、caaaactcat acctgcccac cttgtccagc accagagctg ctcggaggac catccgtgtt 2880
991、cctgtttcca cccaagccca aagatactct gatgatttca cgcacacccg aagtcacttg 2940
992、cgtggtcgtg gacgtgtccc acgaggaccc cgaagtcaag tttaactggt acgtggacgg 3000
993、cgtcgaggtg cataatgcta agacaaaacc ccgagaggaa cagtacaact ctacctatag 3060
994、ggtcgtgagt gtcctgacag tgctccacca ggattggctg aacggaaagg agtataagtg 3120
995、caaagtgtct aataaggcac tgcctgcccc aatcgagaaa acaattagta aggccaaagg 3180
996、gcagcccaga gaacctcagg tgtacactct gcctccatct cgggacgagc tcactaagaa 3240
997、ccaggtcagt ctgacctgtc tcgtgaaagg gttctatcct agtgatatcg ctgtggagtg 3300
998、ggaatcaaat ggtcagccag agaacaatta caagaccaca ccccctgtcc tggacagcga 3360
999、tggctccttc tttctgtatt ccaagctcac cgtggacaaa tctcgatggc agcagggaaa 3420
1000、cgtctttagt tgttcagtga tgcacgaagc cctccataac cactacactc agaaaagcct 3480
1001、cagcctcagc cctgggaaat gataagcggc cgcaagctta agagcttaag ctagagctcg 3540
1002、ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 3600
1003、gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 3660
1004、tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 3720
1005、caagggggag gattgggaag acaatagcag gcatgctggg gagagtctag agtcgactgg 3780
1006、ggagagatct gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc 3840
1007、gctcactgag gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc 3900
1008、agtgagcgag cgagcgcgca gagagggagt ggccaac 3937
1009、<210> 20
1010、<211> 3224
1011、<212> dna
1012、<213> 人工序列
1013、<220>
1014、<223> exg102-10
1015、<400> 20
1016、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
1017、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
1018、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
1019、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
1020、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
1021、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
1022、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
1023、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
1024、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
1025、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
1026、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
1027、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
1028、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
1029、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
1030、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
1031、aagctgcgga attgtacccg cggccgatcc accggtccgg aattacgcgt ctcgagagaa 960
1032、ttcgccacca tggtgtctta ttgggatact ggcgtgctgc tctgtgccct cctgagttgc 1020
1033、ctgctcctga ctggttcttc ttctgggtcc gatactgggc gccccttcgt ggagatgtac 1080
1034、tccgagatcc ctgaaatcat tcacatgact gagggtcggg aactggtcat cccatgccgc 1140
1035、gtgacctctc ccaacattac tgtgaccctg aagaaattcc ctctggacac cctcatccca 1200
1036、gatgggaaga ggatcatttg ggactcaaga aagggtttta tcatcagcaa cgctacatac 1260
1037、aaggagattg gcctgctcac ctgcgaagca acagtgaacg gacacctgta caagactaat 1320
1038、tatctcaccc atagacagac aaacactatc attgatgtgg tcctgtcacc aagccacggc 1380
1039、atcgagctca gcgtcggtga aaagctggtg ctcaattgta cagcccggac tgagctgaac 1440
1040、gtgggcattg acttcaattg ggaatacccc agctccaagc accagcataa gaaactggtg 1500
1041、aaccgcgatc tcaaaaccca gtccggatct gagatgaaga aatttctgag caccctcaca 1560
1042、atcgacggcg tgacacgatc cgatcaggga ctgtatactt gcgccgcttc tagtggcctg 1620
1043、atgaccaaga aaaatagcac attcgtcagg gtgcacgaaa agggcggcgg cggaggcagc 1680
1044、ggcggcggcg gaggcgccca gcaagaagag tgcgagtggg atccctggac ctgcgagcac 1740
1045、atgggatccg gcagcgccac cggaggatcc ggaagcaccg cctccagcgg ctccggcagc 1800
1046、gccacccacc aggaggagtg tgagtgggac ccctggacct gcgaacacat gctggaggac 1860
1047、aaaactcata cctgcccacc ttgtccagca ccagagctgc tcggaggacc atccgtgttc 1920
1048、ctgtttccac ccaagcccaa agatactctg atgatttcac gcacacccga agtcacttgc 1980
1049、gtggtcgtgg acgtgtccca cgaggacccc gaagtcaagt ttaactggta cgtggacggc 2040
1050、gtcgaggtgc ataatgctaa gacaaaaccc cgagaggaac agtacaactc tacctatagg 2100
1051、gtcgtgagtg tcctgacagt gctccaccag gattggctga acggaaagga gtataagtgc 2160
1052、aaagtgtcta ataaggcact gcctgcccca atcgagaaaa caattagtaa ggccaaaggg 2220
1053、cagcccagag aacctcaggt gtacactctg cctccatctc gggacgagct cactaagaac 2280
1054、caggtcagtc tgacctgtct cgtgaaaggg ttctatccta gtgatatcgc tgtggagtgg 2340
1055、gaatcaaatg gtcagccaga gaacaattac aagaccacac cccctgtcct ggacagcgat 2400
1056、ggctccttct ttctgtattc caagctcacc gtggacaaat ctcgatggca gcagggaaac 2460
1057、gtctttagtt gttcagtgat gcacgaagcc ctccataacc actacactca gaaaagcctc 2520
1058、agcctcagcc ctgggaaatg ataagcggcc gcaagcttaa gagatctata atcaacctct 2580
1059、ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct 2640
1060、atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat 2700
1061、tttctcctcc ttgtataaat cctggttagt tcttgccacg gcggaactca tcgccgcctg 2760
1062、ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttaag 2820
1063、cttatcgata ccgtcgacta gagctcgctg atcagcctcg actgtgcctt ctagttgcca 2880
1064、gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac 2940
1065、tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat 3000
1066、tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagtct agagcaggca 3060
1067、tgctggggag agatcgatct gaggaacccc tagtgatgga gttggccact ccctctctgc 3120
1068、gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc 3180
1069、gggcggcctc agtgagcgag cgagcgcgca gagagggagt ggcc 3224
1070、<210> 21
1071、<211> 3937
1072、<212> dna
1073、<213> 人工序列
1074、<220>
1075、<223> exg102-11
1076、<400> 21
1077、ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60
1078、cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 120
1079、gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa 180
1080、tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg 240
1081、gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg 300
1082、tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta 360
1083、cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt 420
1084、gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac 480
1085、tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc 540
1086、cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta 600
1087、tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca 660
1088、ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc 720
1089、aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc 780
1090、tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc 840
1091、cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag 900
1092、gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg 960
1093、cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc 1020
1094、ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc 1080
1095、tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc 1140
1096、agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag 1200
1097、gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg 1260
1098、tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct 1320
1099、tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg 1380
1100、cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag 1440
1101、gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc 1500
1102、cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag 1560
1103、ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc 1620
1104、gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt 1680
1105、ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc 1740
1106、agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt 1800
1107、catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat 1860
1108、cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaacgcg tctcgagaga 1920
1109、attcgccacc atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg 1980
1110、cctgctcctg actggttctt cttctggggg cggcggcgga ggcgcccagc aagaagagtg 2040
1111、cgagtgggat ccctggacct gcgagcacat gggatccggc agcgccaccg gaggatccgg 2100
1112、aagcaccgcc tccagcggct ccggcagcgc cacccaccag gaggagtgtg agtgggaccc 2160
1113、ctggacctgc gaacacatgc tggagggcgg cggcggaggc agctccgata ctgggcgccc 2220
1114、cttcgtggag atgtactccg agatccctga aatcattcac atgactgagg gtcgggaact 2280
1115、ggtcatccca tgccgcgtga cctctcccaa cattactgtg accctgaaga aattccctct 2340
1116、ggacaccctc atcccagatg ggaagaggat catttgggac tcaagaaagg gttttatcat 2400
1117、cagcaacgct acatacaagg agattggcct gctcacctgc gaagcaacag tgaacggaca 2460
1118、cctgtacaag actaattatc tcacccatag acagacaaac actatcattg atgtggtcct 2520
1119、gtcaccaagc cacggcatcg agctcagcgt cggtgaaaag ctggtgctca attgtacagc 2580
1120、ccggactgag ctgaacgtgg gcattgactt caattgggaa taccccagct ccaagcacca 2640
1121、gcataagaaa ctggtgaacc gcgatctcaa aacccagtcc ggatctgaga tgaagaaatt 2700
1122、tctgagcacc ctcacaatcg acggcgtgac acgatccgat cagggactgt atacttgcgc 2760
1123、cgcttctagt ggcctgatga ccaagaaaaa tagcacattc gtcagggtgc acgaaaagga 2820
1124、caaaactcat acctgcccac cttgtccagc accagagctg ctcggaggac catccgtgtt 2880
1125、cctgtttcca cccaagccca aagatactct gatgatttca cgcacacccg aagtcacttg 2940
1126、cgtggtcgtg gacgtgtccc acgaggaccc cgaagtcaag tttaactggt acgtggacgg 3000
1127、cgtcgaggtg cataatgcta agacaaaacc ccgagaggaa cagtacaact ctacctatag 3060
1128、ggtcgtgagt gtcctgacag tgctccacca ggattggctg aacggaaagg agtataagtg 3120
1129、caaagtgtct aataaggcac tgcctgcccc aatcgagaaa acaattagta aggccaaagg 3180
1130、gcagcccaga gaacctcagg tgtacactct gcctccatct cgggacgagc tcactaagaa 3240
1131、ccaggtcagt ctgacctgtc tcgtgaaagg gttctatcct agtgatatcg ctgtggagtg 3300
1132、ggaatcaaat ggtcagccag agaacaatta caagaccaca ccccctgtcc tggacagcga 3360
1133、tggctccttc tttctgtatt ccaagctcac cgtggacaaa tctcgatggc agcagggaaa 3420
1134、cgtctttagt tgttcagtga tgcacgaagc cctccataac cactacactc agaaaagcct 3480
1135、cagcctcagc cctgggaaat gataagcggc cgcaagctta agagcttaag ctagagctcg 3540
1136、ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 3600
1137、gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 3660
1138、tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 3720
1139、caagggggag gattgggaag acaatagcag gcatgctggg gagagtctag agtcgactgg 3780
1140、ggagagatct gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc 3840
1141、gctcactgag gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc 3900
1142、agtgagcgag cgagcgcgca gagagggagt ggccaac 3937
1143、<210> 22
1144、<211> 2941
1145、<212> dna
1146、<213> 人工序列
1147、<220>
1148、<223> exg102-12
1149、<400> 22
1150、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
1151、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
1152、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
1153、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
1154、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
1155、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
1156、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
1157、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
1158、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
1159、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
1160、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
1161、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
1162、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
1163、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
1164、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
1165、aagctgcgga attgtacccg cggccgatcc accggtccgg aattcgccac catggtgtct 960
1166、tattgggata ctggcgtgct gctctgtgcc ctcctgagtt gcctgctcct gactggttct 1020
1167、tcttctgggg gcggcggcgg aggcgcccag caagaagagt gcgagtggga tccctggacc 1080
1168、tgcgagcaca tgggatccgg cagcgccacc ggaggatccg gaagcaccgc ctccagcggc 1140
1169、tccggcagcg ccacccacca ggaggagtgt gagtgggacc cctggacctg cgaacacatg 1200
1170、ctggagggcg gcggcggagg cagctccgat actgggcgcc ccttcgtgga gatgtactcc 1260
1171、gagatccctg aaatcattca catgactgag ggtcgggaac tggtcatccc atgccgcgtg 1320
1172、acctctccca acattactgt gaccctgaag aaattccctc tggacaccct catcccagat 1380
1173、gggaagagga tcatttggga ctcaagaaag ggttttatca tcagcaacgc tacatacaag 1440
1174、gagattggcc tgctcacctg cgaagcaaca gtgaacggac acctgtacaa gactaattat 1500
1175、ctcacccata gacagacaaa cactatcatt gatgtggtcc tgtcaccaag ccacggcatc 1560
1176、gagctcagcg tcggtgaaaa gctggtgctc aattgtacag cccggactga gctgaacgtg 1620
1177、ggcattgact tcaattggga ataccccagc tccaagcacc agcataagaa actggtgaac 1680
1178、cgcgatctca aaacccagtc cggatctgag atgaagaaat ttctgagcac cctcacaatc 1740
1179、gacggcgtga cacgatccga tcagggactg tatacttgcg ccgcttctag tggcctgatg 1800
1180、accaagaaaa atagcacatt cgtcagggtg cacgaaaagg acaaaactca tacctgccca 1860
1181、ccttgtccag caccagagct gctcggagga ccatccgtgt tcctgtttcc acccaagccc 1920
1182、aaagatactc tgatgatttc acgcacaccc gaagtcactt gcgtggtcgt ggacgtgtcc 1980
1183、cacgaggacc ccgaagtcaa gtttaactgg tacgtggacg gcgtcgaggt gcataatgct 2040
1184、aagacaaaac cccgagagga acagtacaac tctacctata gggtcgtgag tgtcctgaca 2100
1185、gtgctccacc aggattggct gaacggaaag gagtataagt gcaaagtgtc taataaggca 2160
1186、ctgcctgccc caatcgagaa aacaattagt aaggccaaag ggcagcccag agaacctcag 2220
1187、gtgtacactc tgcctccatc tcgggacgag ctcactaaga accaggtcag tctgacctgt 2280
1188、ctcgtgaaag ggttctatcc tagtgatatc gctgtggagt gggaatcaaa tggtcagcca 2340
1189、gagaacaatt acaagaccac accccctgtc ctggacagcg atggctcctt ctttctgtat 2400
1190、tccaagctca ccgtggacaa atctcgatgg cagcagggaa acgtctttag ttgttcagtg 2460
1191、atgcacgaag ccctccataa ccactacact cagaaaagcc tcagcctcag ccctgggaaa 2520
1192、tgataagcgg ccgcaagctt atcgataccg tcgactagag ctcgctgatc agcctcgact 2580
1193、gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg 2640
1194、gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg 2700
1195、agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg 2760
1196、gaagtctaga gcaggcatgc tggggagaga tcgatctgag gaacccctag tgatggagtt 2820
1197、ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg 2880
1198、acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc 2940
1199、c 2941
1200、<210> 23
1201、<211> 2603
1202、<212> dna
1203、<213> 人工序列
1204、<220>
1205、<223> exg102-13
1206、<400> 23
1207、ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60
1208、ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatg cacgcgtgga 120
1209、tctgagttca attcacgcgt ggtacctctg gtcgttacat aacttacggt aaatggcccg 180
1210、cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 240
1211、gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 300
1212、cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac 360
1213、ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg 420
1214、cagtacatct actcgaggcc acgttctgct tcactctccc catctccccc ccctccccac 480
1215、ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg 540
1216、ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga 600
1217、gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc 660
1218、ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagcg ggatcagcca 720
1219、ccgcggtggc ggcctagagt cgacgaggaa ctgaaaaacc agaaagttaa ctggtaagtt 780
1220、tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg 840
1221、ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact tctgctctaa 900
1222、aagctgcgga attgtacccg cggccgatcc accggtccgg aattacgcgt ctcgagagaa 960
1223、ttcgccacca tggtgtctta ttgggatact ggcgtgctgc tctgtgccct cctgagttgc 1020
1224、ctgctcctga ctggttcttc ttctgggtcc gatactgggc gccccttcgt ggagatgtac 1080
1225、tccgagatcc ctgaaatcat tcacatgact gagggtcggg aactggtcat cccatgccgc 1140
1226、gtgacctctc ccaacattac tgtgaccctg aagaaattcc ctctggacac cctcatccca 1200
1227、gatgggaaga ggatcatttg ggactcaaga aagggtttta tcatcagcaa cgctacatac 1260
1228、aaggagattg gcctgctcac ctgcgaagca acagtgaacg gacacctgta caagactaat 1320
1229、tatctcaccc atagacagac aaacactatc attgatgtgg tcctgtcacc aagccacggc 1380
1230、atcgagctca gcgtcggtga aaagctggtg ctcaattgta cagcccggac tgagctgaac 1440
1231、gtgggcattg acttcaattg ggaatacccc agctccaagc accagcataa gaaactggtg 1500
1232、aaccgcgatc tcaaaaccca gtccggatct gagatgaaga aatttctgag caccctcaca 1560
1233、atcgacggcg tgacacgatc cgatcaggga ctgtatactt gcgccgcttc tagtggcctg 1620
1234、atgaccaaga aaaatagcac attcgtcagg gtgcacgaaa aggacaaaac tcatacctgc 1680
1235、ccaccttgtc cagcaccaga gctgctcgga ggaccatccg tgggcggcgg cggaggcagc 1740
1236、ggcggcggcg gaggcgccca gcaagaagag tgcgagtggg atccctggac ctgcgagcac 1800
1237、atgggatccg gcagcgccac cggaggatcc ggaagcaccg cctccagcgg ctccggcagc 1860
1238、gccacccacc aggaggagtg tgagtgggac ccctggacct gcgaacacat gctggagtga 1920
1239、taagcggccg caagcttaag agatctataa tcaacctctg gattacaaaa tttgtgaaag 1980
1240、attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat 2040
1241、gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc 2100
1242、ctggttagtt cttgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg 2160
1243、ggctcggctg ttgggcactg acaattccgt ggtgttaagc ttatcgatac cgtcgactag 2220
1244、agctcgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc 2280
1245、ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga 2340
1246、ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca 2400
1247、ggacagcaag ggggaggatt gggaagtcta gagcaggcat gctggggaga gatcgatctg 2460
1248、aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 2520
1249、ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc 2580
1250、gagcgcgcag agagggagtg gcc 2603
1251、<210> 24
1252、<211> 5
1253、<212> prt
1254、<213> 人工序列
1255、<220>
1256、<223> 示例性肽接头
1257、<400> 24
1258、asp gly gly gly ser
1259、1 5
1260、<210> 25
1261、<211> 5
1262、<212> prt
1263、<213> 人工序列
1264、<220>
1265、<223> 示例性肽接头
1266、<400> 25
1267、thr gly glu lys pro
1268、1 5
1269、<210> 26
1270、<211> 4
1271、<212> prt
1272、<213> 人工序列
1273、<220>
1274、<223> 示例性肽接头
1275、<400> 26
1276、gly gly arg arg
1277、1
1278、<210> 27
1279、<211> 24
1280、<212> prt
1281、<213> 人工序列
1282、<220>
1283、<223> 示例性肽接头
1284、<400> 27
1285、gly gly gly gly ser gly gly gly gly ser gly gly gly gly gly gly
1286、1 5 10 15
1287、ser gly ser gly gly gly gly ser
1288、 20
1289、<210> 28
1290、<211> 34
1291、<212> prt
1292、<213> 人工序列
1293、<220>
1294、<223> 示例性肽接头
1295、<400> 28
1296、gly gly gly gly ser gly gly gly gly ser gly gly gly gly gly gly
1297、1 5 10 15
1298、ser gly ser gly gly gly gly ser gly gly gly gly ser gly gly gly
1299、 20 25 30
1300、gly ser
1301、<210> 29
1302、<211> 14
1303、<212> prt
1304、<213> 人工序列
1305、<220>
1306、<223> 示例性肽接头
1307、<400> 29
1308、glu gly lys ser ser gly ser gly ser glu ser lys val asp
1309、1 5 10
1310、<210> 30
1311、<211> 16
1312、<212> prt
1313、<213> 人工序列
1314、<220>
1315、<223> 示例性肽接头
1316、<400> 30
1317、lys glu ser gly ser val ser ser glu gln leu ala gln phe arg ser
1318、1 5 10 15
1319、<210> 31
1320、<211> 8
1321、<212> prt
1322、<213> 人工序列
1323、<220>
1324、<223> 示例性肽接头
1325、<400> 31
1326、gly gly arg arg gly gly gly ser
1327、1 5
1328、<210> 32
1329、<211> 9
1330、<212> prt
1331、<213> 人工序列
1332、<220>
1333、<223> 示例性肽接头
1334、<400> 32
1335、leu arg gln arg asp gly glu arg pro
1336、1 5
1337、<210> 33
1338、<211> 12
1339、<212> prt
1340、<213> 人工序列
1341、<220>
1342、<223> 示例性肽接头
1343、<400> 33
1344、leu arg gln lys asp gly gly gly ser glu arg pro
1345、1 5 10
1346、<210> 34
1347、<211> 16
1348、<212> prt
1349、<213> 人工序列
1350、<220>
1351、<223> 示例性肽接头
1352、<400> 34
1353、leu arg gln lys asp gly gly gly ser gly gly gly ser glu arg pro
1354、1 5 10 15
1355、<210> 35
1356、<211> 16
1357、<212> prt
1358、<213> 人工序列
1359、<220>
1360、<223> 示例性肽接头
1361、<400> 35
1362、gly ser thr ser gly ser gly lys pro gly ser gly glu gly ser thr
1363、1 5 10 15
1364、<210> 36
1365、<211> 14
1366、<212> prt
1367、<213> 人工序列
1368、<220>
1369、<223> 示例性肽接头
1370、<400> 36
1371、gly ser thr ser gly ser gly lys ser ser glu gly lys gly
1372、1 5 10
1373、<210> 37
1374、<211> 18
1375、<212> prt
1376、<213> 人工序列
1377、<220>
1378、<223> 示例性肽接头
1379、<400> 37
1380、lys glu ser gly ser val ser ser glu gln leu ala gln phe arg ser
1381、1 5 10 15
1382、leu asp
1383、<210> 38
1384、<211> 2
1385、<212> prt
1386、<213> 人工序列
1387、<220>
1388、<223> 示例性肽接头
1389、<220>
1390、<221> misc_feature
1391、<222> (1)..(2)
1392、<223> gs可以重复n次,其中n是整数,包括,例如,1、2、3、4、5和6
1393、<400> 38
1394、gly ser
1395、1
1396、<210> 39
1397、<211> 5
1398、<212> prt
1399、<213> 人工序列
1400、<220>
1401、<223> 示例性肽接头
1402、<220>
1403、<221> misc_feature
1404、<222> (1)..(5)
1405、<223> gsggs可以重复n次,其中n是整数,包括,例如,1、2、3、4、5和6
1406、<400> 39
1407、gly ser gly gly ser
1408、1 5
1409、<210> 40
1410、<211> 4
1411、<212> prt
1412、<213> 人工序列
1413、<220>
1414、<223> 示例性肽接头
1415、<220>
1416、<221> misc_feature
1417、<222> (1)..(4)
1418、<223> gggs可以重复n次,其中n是整数,包括,例如,1、2、3、4、5和6
1419、<400> 40
1420、gly gly gly ser
1421、1
1422、<210> 41
1423、<211> 5
1424、<212> prt
1425、<213> 人工序列
1426、<220>
1427、<223> 示例性肽接头
1428、<220>
1429、<221> misc_feature
1430、<222> (1)..(5)
1431、<223> ggggs可以重复n次,其中n是整数,包括,例如,1、2、3、4、5和6
1432、<400> 41
1433、gly gly gly gly ser
1434、1 5
1435、<210> 42
1436、<211> 6
1437、<212> prt
1438、<213> 人工序列
1439、<220>
1440、<223> 示例性肽接头
1441、<220>
1442、<221> misc_feature
1443、<222> (1)..(6)
1444、<223> gggggs可以重复n次,其中n是整数,包括,例如,1、2、3、4、5和6
1445、<400> 42
1446、gly gly gly gly gly ser
1447、1 5
1448、<210> 43
1449、<211> 735
1450、<212> prt
1451、<213> 人工序列
1452、<220>
1453、<223> aav2(uniprot: p03135-1)
1454、<400> 43
1455、met ala ala asp gly tyr leu pro asp trp leu glu asp thr leu ser
1456、1 5 10 15
1457、glu gly ile arg gln trp trp lys leu lys pro gly pro pro pro pro
1458、 20 25 30
1459、lys pro ala glu arg his lys asp asp ser arg gly leu val leu pro
1460、 35 40 45
1461、gly tyr lys tyr leu gly pro phe asn gly leu asp lys gly glu pro
1462、 50 55 60
1463、val asn glu ala asp ala ala ala leu glu his asp lys ala tyr asp
1464、65 70 75 80
1465、arg gln leu asp ser gly asp asn pro tyr leu lys tyr asn his ala
1466、 85 90 95
1467、asp ala glu phe gln glu arg leu lys glu asp thr ser phe gly gly
1468、 100 105 110
1469、asn leu gly arg ala val phe gln ala lys lys arg val leu glu pro
1470、 115 120 125
1471、leu gly leu val glu glu pro val lys thr ala pro gly lys lys arg
1472、 130 135 140
1473、pro val glu his ser pro val glu pro asp ser ser ser gly thr gly
1474、145 150 155 160
1475、lys ala gly gln gln pro ala arg lys arg leu asn phe gly gln thr
1476、 165 170 175
1477、gly asp ala asp ser val pro asp pro gln pro leu gly gln pro pro
1478、 180 185 190
1479、ala ala pro ser gly leu gly thr asn thr met ala thr gly ser gly
1480、 195 200 205
1481、ala pro met ala asp asn asn glu gly ala asp gly val gly asn ser
1482、 210 215 220
1483、ser gly asn trp his cys asp ser thr trp met gly asp arg val ile
1484、225 230 235 240
1485、thr thr ser thr arg thr trp ala leu pro thr tyr asn asn his leu
1486、 245 250 255
1487、tyr lys gln ile ser ser gln ser gly ala ser asn asp asn his tyr
1488、 260 265 270
1489、phe gly tyr ser thr pro trp gly tyr phe asp phe asn arg phe his
1490、 275 280 285
1491、cys his phe ser pro arg asp trp gln arg leu ile asn asn asn trp
1492、 290 295 300
1493、gly phe arg pro lys arg leu asn phe lys leu phe asn ile gln val
1494、305 310 315 320
1495、lys glu val thr gln asn asp gly thr thr thr ile ala asn asn leu
1496、 325 330 335
1497、thr ser thr val gln val phe thr asp ser glu tyr gln leu pro tyr
1498、 340 345 350
1499、val leu gly ser ala his gln gly cys leu pro pro phe pro ala asp
1500、 355 360 365
1501、val phe met val pro gln tyr gly tyr leu thr leu asn asn gly ser
1502、 370 375 380
1503、gln ala val gly arg ser ser phe tyr cys leu glu tyr phe pro ser
1504、385 390 395 400
1505、gln met leu arg thr gly asn asn phe thr phe ser tyr thr phe glu
1506、 405 410 415
1507、asp val pro phe his ser ser tyr ala his ser gln ser leu asp arg
1508、 420 425 430
1509、leu met asn pro leu ile asp gln tyr leu tyr tyr leu ser arg thr
1510、 435 440 445
1511、asn thr pro ser gly thr thr thr gln ser arg leu gln phe ser gln
1512、 450 455 460
1513、ala gly ala ser asp ile arg asp gln ser arg asn trp leu pro gly
1514、465 470 475 480
1515、pro cys tyr arg gln gln arg val ser lys thr ser ala asp asn asn
1516、 485 490 495
1517、asn ser glu tyr ser trp thr gly ala thr lys tyr his leu asn gly
1518、 500 505 510
1519、arg asp ser leu val asn pro gly pro ala met ala ser his lys asp
1520、 515 520 525
1521、asp glu glu lys phe phe pro gln ser gly val leu ile phe gly lys
1522、 530 535 540
1523、gln gly ser glu lys thr asn val asp ile glu lys val met ile thr
1524、545 550 555 560
1525、asp glu glu glu ile arg thr thr asn pro val ala thr glu gln tyr
1526、 565 570 575
1527、gly ser val ser thr asn leu gln arg gly asn arg gln ala ala thr
1528、 580 585 590
1529、ala asp val asn thr gln gly val leu pro gly met val trp gln asp
1530、 595 600 605
1531、arg asp val tyr leu gln gly pro ile trp ala lys ile pro his thr
1532、 610 615 620
1533、asp gly his phe his pro ser pro leu met gly gly phe gly leu lys
1534、625 630 635 640
1535、his pro pro pro gln ile leu ile lys asn thr pro val pro ala asn
1536、 645 650 655
1537、pro ser thr thr phe ser ala ala lys phe ala ser phe ile thr gln
1538、 660 665 670
1539、tyr ser thr gly gln val ser val glu ile glu trp glu leu gln lys
1540、 675 680 685
1541、glu asn ser lys arg trp asn pro glu ile gln tyr thr ser asn tyr
1542、 690 695 700
1543、asn lys ser val asn val asp phe thr val asp thr asn gly val tyr
1544、705 710 715 720
1545、ser glu pro arg pro ile gly thr arg tyr leu thr arg asn leu
1546、 725 730 735
1547、<210> 44
1548、<211> 738
1549、<212> prt
1550、<213> 人工序列
1551、<220>
1552、<223> aav8(uniprot q8jqf8_9viru)
1553、<400> 44
1554、met ala ala asp gly tyr leu pro asp trp leu glu asp asn leu ser
1555、1 5 10 15
1556、glu gly ile arg glu trp trp ala leu lys pro gly ala pro lys pro
1557、 20 25 30
1558、lys ala asn gln gln lys gln asp asp gly arg gly leu val leu pro
1559、 35 40 45
1560、gly tyr lys tyr leu gly pro phe asn gly leu asp lys gly glu pro
1561、 50 55 60
1562、val asn ala ala asp ala ala ala leu glu his asp lys ala tyr asp
1563、65 70 75 80
1564、gln gln leu gln ala gly asp asn pro tyr leu arg tyr asn his ala
1565、 85 90 95
1566、asp ala glu phe gln glu arg leu gln glu asp thr ser phe gly gly
1567、 100 105 110
1568、asn leu gly arg ala val phe gln ala lys lys arg val leu glu pro
1569、 115 120 125
1570、leu gly leu val glu glu gly ala lys thr ala pro gly lys lys arg
1571、 130 135 140
1572、pro val glu pro ser pro gln arg ser pro asp ser ser thr gly ile
1573、145 150 155 160
1574、gly lys lys gly gln gln pro ala arg lys arg leu asn phe gly gln
1575、 165 170 175
1576、thr gly asp ser glu ser val pro asp pro gln pro leu gly glu pro
1577、 180 185 190
1578、pro ala ala pro ser gly val gly pro asn thr met ala ala gly gly
1579、 195 200 205
1580、gly ala pro met ala asp asn asn glu gly ala asp gly val gly ser
1581、 210 215 220
1582、ser ser gly asn trp his cys asp ser thr trp leu gly asp arg val
1583、225 230 235 240
1584、ile thr thr ser thr arg thr trp ala leu pro thr tyr asn asn his
1585、 245 250 255
1586、leu tyr lys gln ile ser asn gly thr ser gly gly ala thr asn asp
1587、 260 265 270
1588、asn thr tyr phe gly tyr ser thr pro trp gly tyr phe asp phe asn
1589、 275 280 285
1590、arg phe his cys his phe ser pro arg asp trp gln arg leu ile asn
1591、 290 295 300
1592、asn asn trp gly phe arg pro lys arg leu ser phe lys leu phe asn
1593、305 310 315 320
1594、ile gln val lys glu val thr gln asn glu gly thr lys thr ile ala
1595、 325 330 335
1596、asn asn leu thr ser thr ile gln val phe thr asp ser glu tyr gln
1597、 340 345 350
1598、leu pro tyr val leu gly ser ala his gln gly cys leu pro pro phe
1599、 355 360 365
1600、pro ala asp val phe met ile pro gln tyr gly tyr leu thr leu asn
1601、 370 375 380
1602、asn gly ser gln ala val gly arg ser ser phe tyr cys leu glu tyr
1603、385 390 395 400
1604、phe pro ser gln met leu arg thr gly asn asn phe gln phe thr tyr
1605、 405 410 415
1606、thr phe glu asp val pro phe his ser ser tyr ala his ser gln ser
1607、 420 425 430
1608、leu asp arg leu met asn pro leu ile asp gln tyr leu tyr tyr leu
1609、 435 440 445
1610、ser arg thr gln thr thr gly gly thr ala asn thr gln thr leu gly
1611、 450 455 460
1612、phe ser gln gly gly pro asn thr met ala asn gln ala lys asn trp
1613、465 470 475 480
1614、leu pro gly pro cys tyr arg gln gln arg val ser thr thr thr gly
1615、 485 490 495
1616、gln asn asn asn ser asn phe ala trp thr ala gly thr lys tyr his
1617、 500 505 510
1618、leu asn gly arg asn ser leu ala asn pro gly ile ala met ala thr
1619、 515 520 525
1620、his lys asp asp glu glu arg phe phe pro ser asn gly ile leu ile
1621、 530 535 540
1622、phe gly lys gln asn ala ala arg asp asn ala asp tyr ser asp val
1623、545 550 555 560
1624、met leu thr ser glu glu glu ile lys thr thr asn pro val ala thr
1625、 565 570 575
1626、glu glu tyr gly ile val ala asp asn leu gln gln gln asn thr ala
1627、 580 585 590
1628、pro gln ile gly thr val asn ser gln gly ala leu pro gly met val
1629、 595 600 605
1630、trp gln asn arg asp val tyr leu gln gly pro ile trp ala lys ile
1631、 610 615 620
1632、pro his thr asp gly asn phe his pro ser pro leu met gly gly phe
1633、625 630 635 640
1634、gly leu lys his pro pro pro gln ile leu ile lys asn thr pro val
1635、 645 650 655
1636、pro ala asp pro pro thr thr phe asn gln ser lys leu asn ser phe
1637、 660 665 670
1638、ile thr gln tyr ser thr gly gln val ser val glu ile glu trp glu
1639、 675 680 685
1640、leu gln lys glu asn ser lys arg trp asn pro glu ile gln tyr thr
1641、 690 695 700
1642、ser asn tyr tyr lys ser thr ser val asp phe ala val asn thr glu
1643、705 710 715 720
1644、gly val tyr ser glu pro arg pro ile gly thr arg tyr leu thr arg
1645、 725 730 735
1646、asn leu
1647、<210> 45
1648、<211> 736
1649、<212> prt
1650、<213> 人工序列
1651、<220>
1652、<223> aavrh8(uniprot q808y3_9viru)
1653、<400> 45
1654、met ala ala asp gly tyr leu pro asp trp leu glu asp asn leu ser
1655、1 5 10 15
1656、glu gly ile arg glu trp trp asp leu lys pro gly ala pro lys pro
1657、 20 25 30
1658、lys ala asn gln gln lys gln asp asp gly arg gly leu val leu pro
1659、 35 40 45
1660、gly tyr lys tyr leu gly pro phe asn gly leu asp lys gly glu pro
1661、 50 55 60
1662、val asn ala ala asp ala ala ala leu glu his asp lys ala tyr asp
1663、65 70 75 80
1664、gln gln leu lys ala gly asp asn pro tyr leu arg tyr asn his ala
1665、 85 90 95
1666、asp ala glu phe gln glu arg leu gln glu asp thr ser phe gly gly
1667、 100 105 110
1668、asn leu gly arg ala val phe gln ala lys lys arg val leu glu pro
1669、 115 120 125
1670、leu gly leu val glu glu gly ala lys thr ala pro gly lys lys arg
1671、 130 135 140
1672、pro val glu gln ser pro gln glu pro asp ser ser ser gly ile gly
1673、145 150 155 160
1674、lys thr gly gln gln pro ala lys lys arg leu asn phe gly gln thr
1675、 165 170 175
1676、gly asp ser glu ser val pro asp pro gln pro leu gly glu pro pro
1677、 180 185 190
1678、ala ala pro ser gly leu gly pro asn thr met ala ser gly gly gly
1679、 195 200 205
1680、ala pro met ala asp asn asn glu gly ala asp gly val gly asn ser
1681、 210 215 220
1682、ser gly asn trp his cys asp ser thr trp leu gly asp arg val ile
1683、225 230 235 240
1684、thr thr ser thr arg thr trp ala leu pro thr tyr asn asn his leu
1685、 245 250 255
1686、tyr lys gln ile ser asn gly thr ser gly gly ser thr asn asp asn
1687、 260 265 270
1688、thr tyr phe gly tyr ser thr pro trp gly tyr phe asp phe asn arg
1689、 275 280 285
1690、phe his cys his phe ser pro arg asp trp gln arg leu ile asn asn
1691、 290 295 300
1692、asn trp gly phe arg pro lys arg leu asn phe lys leu phe asn ile
1693、305 310 315 320
1694、gln val lys glu val thr thr asn glu gly thr lys thr ile ala asn
1695、 325 330 335
1696、asn leu thr ser thr val gln val phe thr asp ser glu tyr gln leu
1697、 340 345 350
1698、pro tyr val leu gly ser ala his gln gly cys leu pro pro phe pro
1699、 355 360 365
1700、ala asp val phe met val pro gln tyr gly tyr leu thr leu asn asn
1701、 370 375 380
1702、gly ser gln ala leu gly arg ser ser phe tyr cys leu glu tyr phe
1703、385 390 395 400
1704、pro ser gln met leu arg thr gly asn asn phe gln phe ser tyr thr
1705、 405 410 415
1706、phe glu asp val pro phe his ser ser tyr ala his ser gln ser leu
1707、 420 425 430
1708、asp arg leu met asn pro leu ile asp gln tyr leu tyr tyr leu val
1709、 435 440 445
1710、arg thr gln thr thr gly thr gly gly thr gln thr leu ala phe ser
1711、 450 455 460
1712、gln ala gly pro ser ser met ala asn gln ala arg asn trp val pro
1713、465 470 475 480
1714、gly pro cys tyr arg gln gln arg val ser thr thr thr asn gln asn
1715、 485 490 495
1716、asn asn ser asn phe ala trp thr gly ala ala lys phe lys leu asn
1717、 500 505 510
1718、gly arg asp ser leu met asn pro gly val ala met ala ser his lys
1719、 515 520 525
1720、asp asp asp asp arg phe phe pro ser ser gly val leu ile phe gly
1721、 530 535 540
1722、lys gln gly ala gly asn asp gly val asp tyr ser gln val leu ile
1723、545 550 555 560
1724、thr asp glu glu glu ile lys ala thr asn pro val ala thr glu glu
1725、 565 570 575
1726、tyr gly ala val ala ile asn asn gln ala ala asn thr gln ala gln
1727、 580 585 590
1728、thr gly leu val his asn gln gly val ile pro gly met val trp gln
1729、 595 600 605
1730、asn arg asp val tyr leu gln gly pro ile trp ala lys ile pro his
1731、 610 615 620
1732、thr asp gly asn phe his pro ser pro leu met gly gly phe gly leu
1733、625 630 635 640
1734、lys his pro pro pro gln ile leu ile lys asn thr pro val pro ala
1735、 645 650 655
1736、asp pro pro leu thr phe asn gln ala lys leu asn ser phe ile thr
1737、 660 665 670
1738、gln tyr ser thr gly gln val ser val glu ile glu trp glu leu gln
1739、 675 680 685
1740、lys glu asn ser lys arg trp asn pro glu ile gln tyr thr ser asn
1741、 690 695 700
1742、tyr tyr lys ser thr asn val asp phe ala val asn thr glu gly val
1743、705 710 715 720
1744、tyr ser glu pro arg pro ile gly thr arg tyr leu thr arg asn leu
1745、 725 730 735
1746、<210> 46
1747、<211> 736
1748、<212> prt
1749、<213> 人工序列
1750、<220>
1751、<223> aav9(uniprot q6jc40_9viru)
1752、<400> 46
1753、met ala ala asp gly tyr leu pro asp trp leu glu asp asn leu ser
1754、1 5 10 15
1755、glu gly ile arg glu trp trp ala leu lys pro gly ala pro gln pro
1756、 20 25 30
1757、lys ala asn gln gln his gln asp asn ala arg gly leu val leu pro
1758、 35 40 45
1759、gly tyr lys tyr leu gly pro gly asn gly leu asp lys gly glu pro
1760、 50 55 60
1761、val asn ala ala asp ala ala ala leu glu his asp lys ala tyr asp
1762、65 70 75 80
1763、gln gln leu lys ala gly asp asn pro tyr leu lys tyr asn his ala
1764、 85 90 95
1765、asp ala glu phe gln glu arg leu lys glu asp thr ser phe gly gly
1766、 100 105 110
1767、asn leu gly arg ala val phe gln ala lys lys arg leu leu glu pro
1768、 115 120 125
1769、leu gly leu val glu glu ala ala lys thr ala pro gly lys lys arg
1770、 130 135 140
1771、pro val glu gln ser pro gln glu pro asp ser ser ala gly ile gly
1772、145 150 155 160
1773、lys ser gly ala gln pro ala lys lys arg leu asn phe gly gln thr
1774、 165 170 175
1775、gly asp thr glu ser val pro asp pro gln pro ile gly glu pro pro
1776、 180 185 190
1777、ala ala pro ser gly val gly ser leu thr met ala ser gly gly gly
1778、 195 200 205
1779、ala pro val ala asp asn asn glu gly ala asp gly val gly ser ser
1780、 210 215 220
1781、ser gly asn trp his cys asp ser gln trp leu gly asp arg val ile
1782、225 230 235 240
1783、thr thr ser thr arg thr trp ala leu pro thr tyr asn asn his leu
1784、 245 250 255
1785、tyr lys gln ile ser asn ser thr ser gly gly ser ser asn asp asn
1786、 260 265 270
1787、ala tyr phe gly tyr ser thr pro trp gly tyr phe asp phe asn arg
1788、 275 280 285
1789、phe his cys his phe ser pro arg asp trp gln arg leu ile asn asn
1790、 290 295 300
1791、asn trp gly phe arg pro lys arg leu asn phe lys leu phe asn ile
1792、305 310 315 320
1793、gln val lys glu val thr asp asn asn gly val lys thr ile ala asn
1794、 325 330 335
1795、asn leu thr ser thr val gln val phe thr asp ser asp tyr gln leu
1796、 340 345 350
1797、pro tyr val leu gly ser ala his glu gly cys leu pro pro phe pro
1798、 355 360 365
1799、ala asp val phe met ile pro gln tyr gly tyr leu thr leu asn asp
1800、 370 375 380
1801、gly ser gln ala val gly arg ser ser phe tyr cys leu glu tyr phe
1802、385 390 395 400
1803、pro ser gln met leu arg thr gly asn asn phe gln phe ser tyr glu
1804、 405 410 415
1805、phe glu asn val pro phe his ser ser tyr ala his ser gln ser leu
1806、 420 425 430
1807、asp arg leu met asn pro leu ile asp gln tyr leu tyr tyr leu ser
1808、 435 440 445
1809、lys thr ile asn gly ser gly gln asn gln gln thr leu lys phe ser
1810、 450 455 460
1811、val ala gly pro ser asn met ala val gln gly arg asn tyr ile pro
1812、465 470 475 480
1813、gly pro ser tyr arg gln gln arg val ser thr thr val thr gln asn
1814、 485 490 495
1815、asn asn ser glu phe ala trp pro gly ala ser ser trp ala leu asn
1816、 500 505 510
1817、gly arg asn ser leu met asn pro gly pro ala met ala ser his lys
1818、 515 520 525
1819、glu gly glu asp arg phe phe pro leu ser gly ser leu ile phe gly
1820、 530 535 540
1821、lys gln gly thr gly arg asp asn val asp ala asp lys val met ile
1822、545 550 555 560
1823、thr asn glu glu glu ile lys thr thr asn pro val ala thr glu ser
1824、 565 570 575
1825、tyr gly gln val ala thr asn his gln ser ala gln ala gln ala gln
1826、 580 585 590
1827、thr gly trp val gln asn gln gly ile leu pro gly met val trp gln
1828、 595 600 605
1829、asp arg asp val tyr leu gln gly pro ile trp ala lys ile pro his
1830、 610 615 620
1831、thr asp gly asn phe his pro ser pro leu met gly gly phe gly met
1832、625 630 635 640
1833、lys his pro pro pro gln ile leu ile lys asn thr pro val pro ala
1834、 645 650 655
1835、asp pro pro thr ala phe asn lys asp lys leu asn ser phe ile thr
1836、 660 665 670
1837、gln tyr ser thr gly gln val ser val glu ile glu trp glu leu gln
1838、 675 680 685
1839、lys glu asn ser lys arg trp asn pro glu ile gln tyr thr ser asn
1840、 690 695 700
1841、tyr tyr lys ser asn asn val glu phe ala val asn thr glu gly val
1842、705 710 715 720
1843、tyr ser glu pro arg pro ile gly thr arg tyr leu thr arg asn leu
1844、 725 730 735
1845、<210> 47
1846、<211> 738
1847、<212> prt
1848、<213> 人工序列
1849、<220>
1850、<223> aavrh10(uniprot q808w5_9viru)
1851、<400> 47
1852、met ala ala asp gly tyr leu pro asp trp leu glu asp asn leu ser
1853、1 5 10 15
1854、glu gly ile arg glu trp trp asp leu lys pro gly ala pro lys pro
1855、 20 25 30
1856、lys ala asn gln gln lys gln asp asp gly arg gly leu val leu pro
1857、 35 40 45
1858、gly tyr lys tyr leu gly pro phe asn gly leu asp lys gly glu pro
1859、 50 55 60
1860、val asn ala ala asp ala ala ala leu glu his asp lys ala tyr asp
1861、65 70 75 80
1862、gln gln leu lys ala gly asp asn pro tyr leu arg tyr asn his ala
1863、 85 90 95
1864、asp ala glu phe gln glu arg leu gln glu asp thr ser phe gly gly
1865、 100 105 110
1866、asn leu gly arg ala val phe gln ala lys lys arg val leu glu pro
1867、 115 120 125
1868、leu gly leu val glu glu gly ala lys thr ala pro gly lys lys arg
1869、 130 135 140
1870、pro val glu pro ser pro gln arg ser pro asp ser ser thr gly ile
1871、145 150 155 160
1872、gly lys lys gly gln gln pro ala lys lys arg leu asn phe gly gln
1873、 165 170 175
1874、thr gly asp ser glu ser val pro asp pro gln pro ile gly glu pro
1875、 180 185 190
1876、pro ala gly pro ser gly leu gly ser gly thr met ala ala gly gly
1877、 195 200 205
1878、gly ala pro met ala asp asn asn glu gly ala asp gly val gly ser
1879、 210 215 220
1880、ser ser gly asn trp his cys asp ser thr trp leu gly asp arg val
1881、225 230 235 240
1882、ile thr thr ser thr arg thr trp ala leu pro thr tyr asn asn his
1883、 245 250 255
1884、leu tyr lys gln ile ser asn gly thr ser gly gly ser thr asn asp
1885、 260 265 270
1886、asn thr tyr phe gly tyr ser thr pro trp gly tyr phe asp phe asn
1887、 275 280 285
1888、arg phe his cys his phe ser pro arg asp trp gln arg leu ile asn
1889、 290 295 300
1890、asn asn trp gly phe arg pro lys arg leu asn phe lys leu phe asn
1891、305 310 315 320
1892、ile gln val lys glu val thr gln asn glu gly thr lys thr ile ala
1893、 325 330 335
1894、asn asn leu thr ser thr ile gln val phe thr asp ser glu tyr gln
1895、 340 345 350
1896、leu pro tyr val leu gly ser ala his gln gly cys leu pro pro phe
1897、 355 360 365
1898、pro ala asp val phe met ile pro gln tyr gly tyr leu thr leu asn
1899、 370 375 380
1900、asn gly ser gln ala val gly arg ser ser phe tyr cys leu glu tyr
1901、385 390 395 400
1902、phe pro ser gln met leu arg thr gly asn asn phe glu phe ser tyr
1903、 405 410 415
1904、gln phe glu asp val pro phe his ser ser tyr ala his ser gln ser
1905、 420 425 430
1906、leu asp arg leu met asn pro leu ile asp gln tyr leu tyr tyr leu
1907、 435 440 445
1908、ser arg thr gln ser thr gly gly thr ala gly thr gln gln leu leu
1909、 450 455 460
1910、phe ser gln ala gly pro asn asn met ser ala gln ala lys asn trp
1911、465 470 475 480
1912、leu pro gly pro cys tyr arg gln gln arg val ser thr thr leu ser
1913、 485 490 495
1914、gln asn asn asn ser asn phe ala trp thr gly ala thr lys tyr his
1915、 500 505 510
1916、leu asn gly arg asp ser leu val asn pro gly val ala met ala thr
1917、 515 520 525
1918、his lys asp asp glu glu arg phe phe pro ser ser gly val leu met
1919、 530 535 540
1920、phe gly lys gln gly ala gly lys asp asn val asp tyr ser ser val
1921、545 550 555 560
1922、met leu thr ser glu glu glu ile lys thr thr asn pro val ala thr
1923、 565 570 575
1924、glu gln tyr gly val val ala asp asn leu gln gln gln asn ala ala
1925、 580 585 590
1926、pro ile val gly ala val asn ser gln gly ala leu pro gly met val
1927、 595 600 605
1928、trp gln asn arg asp val tyr leu gln gly pro ile trp ala lys ile
1929、 610 615 620
1930、pro his thr asp gly asn phe his pro ser pro leu met gly gly phe
1931、625 630 635 640
1932、gly leu lys his pro pro pro gln ile leu ile lys asn thr pro val
1933、 645 650 655
1934、pro ala asp pro pro thr thr phe ser gln ala lys leu ala ser phe
1935、 660 665 670
1936、ile thr gln tyr ser thr gly gln val ser val glu ile glu trp glu
1937、 675 680 685
1938、leu gln lys glu asn ser lys arg trp asn pro glu ile gln tyr thr
1939、 690 695 700
1940、ser asn tyr tyr lys ser thr asn val asp phe ala val asn thr asp
1941、705 710 715 720
1942、gly thr tyr ser glu pro arg pro ile gly thr arg tyr leu thr arg
1943、 725 730 735
1944、asn leu
1945、<210> 48
1946、<211> 735
1947、<212> prt
1948、<213> 人工序列
1949、<220>
1950、<223> aav2v
1951、<400> 48
1952、met ala ala asp gly tyr leu pro asp trp leu glu asp thr leu ser
1953、1 5 10 15
1954、glu gly ile arg gln trp trp lys leu lys pro gly pro pro pro pro
1955、 20 25 30
1956、lys pro ala glu arg his lys asp asp ser arg gly leu val leu pro
1957、 35 40 45
1958、gly tyr lys tyr leu gly pro phe asn gly leu asp lys gly glu pro
1959、 50 55 60
1960、val asn glu ala asp ala ala ala leu glu his asp lys ala tyr asp
1961、65 70 75 80
1962、arg gln leu asp ser gly asp asn pro tyr leu lys tyr asn his ala
1963、 85 90 95
1964、asp ala glu phe gln glu arg leu lys glu asp thr ser phe gly gly
1965、 100 105 110
1966、asn leu gly arg ala val phe gln ala lys lys arg val leu glu pro
1967、 115 120 125
1968、leu gly leu val glu glu pro val lys thr ala pro gly lys lys arg
1969、 130 135 140
1970、pro val glu his ser pro val glu pro asp ser ser ser gly thr gly
1971、145 150 155 160
1972、lys ala gly gln gln pro ala arg lys arg leu asn phe gly gln thr
1973、 165 170 175
1974、gly asp ala asp ser val pro asp pro gln pro leu gly gln pro pro
1975、 180 185 190
1976、ala ala pro ser gly leu gly thr asn thr met ala thr gly ser gly
1977、 195 200 205
1978、ala pro met ala asp asn asn glu gly ala asp gly val gly asn ser
1979、 210 215 220
1980、ser gly asn trp his cys asp ser thr trp met gly asp arg val ile
1981、225 230 235 240
1982、thr thr ser thr arg thr trp ala leu pro thr tyr asn asn his leu
1983、 245 250 255
1984、tyr lys gln ile ser ser gln ser gly ala ser asn asp asn his tyr
1985、 260 265 270
1986、phe gly tyr ser thr pro trp gly tyr phe asp phe asn arg phe his
1987、 275 280 285
1988、cys his phe ser pro arg asp trp gln arg leu ile asn asn asn trp
1989、 290 295 300
1990、gly phe arg pro lys arg leu asn phe lys leu phe asn ile gln val
1991、305 310 315 320
1992、lys glu val thr gln asn asp gly thr thr thr ile ala asn asn leu
1993、 325 330 335
1994、thr ser thr val gln val phe thr asp ser glu tyr gln leu pro tyr
1995、 340 345 350
1996、val leu gly ser ala his gln gly cys leu pro pro phe pro ala asp
1997、 355 360 365
1998、val phe met val pro gln tyr gly tyr leu thr leu asn asn gly ser
1999、 370 375 380
2000、gln ala val gly arg ser ser phe tyr cys leu glu tyr phe pro ser
2001、385 390 395 400
2002、gln met leu arg thr gly asn asn phe thr phe ser tyr thr phe glu
2003、 405 410 415
2004、asp val pro phe his ser ser tyr ala his ser gln ser leu asp arg
2005、 420 425 430
2006、leu met asn pro leu ile asp gln tyr leu tyr phe leu ser arg thr
2007、 435 440 445
2008、asn thr pro ser gly thr thr thr gln ser arg leu gln phe ser gln
2009、 450 455 460
2010、ala gly ala ser asp ile arg asp gln ser arg asn trp leu pro gly
2011、465 470 475 480
2012、pro cys tyr arg gln gln gly val ser lys val ser ala asp asn asn
2013、 485 490 495
2014、asn ser glu phe ser trp thr gly ala thr lys tyr his leu asn gly
2015、 500 505 510
2016、arg asp ser leu val asn pro gly pro ala met ala ser his lys asp
2017、 515 520 525
2018、asp glu glu lys phe phe pro gln ser gly val leu ile phe gly lys
2019、 530 535 540
2020、gln gly ser glu lys thr asn val asp ile glu lys val met ile thr
2021、545 550 555 560
2022、asp glu glu glu ile arg thr thr asn pro val ala thr glu gln tyr
2023、 565 570 575
2024、gly ser val ser thr asn leu gln ser gly asn thr gln ala ala thr
2025、 580 585 590
2026、ala asp val asn thr gln gly val leu pro gly met val trp gln asp
2027、 595 600 605
2028、arg asp val tyr leu gln gly pro ile trp ala lys ile pro his thr
2029、 610 615 620
2030、asp gly his phe his pro ser pro leu met gly gly phe gly leu lys
2031、625 630 635 640
2032、his pro pro pro gln ile leu ile lys asn thr pro val pro ala asn
2033、 645 650 655
2034、pro ser thr thr phe ser ala ala lys phe ala ser phe ile thr gln
2035、 660 665 670
2036、tyr ser thr gly gln val ser val glu ile glu trp glu leu gln lys
2037、 675 680 685
2038、glu asn ser lys arg trp asn pro glu ile gln tyr thr ser asn tyr
2039、 690 695 700
2040、asn lys ser val asn val asp phe thr val asp thr asn gly val tyr
2041、705 710 715 720
2042、ser glu pro arg pro ile gly thr arg phe leu thr arg asn leu
2043、 725 730 735
2044、<210> 49
2045、<211> 736
2046、<212> prt
2047、<213> 人工序列
2048、<220>
2049、<223> aav44-9
2050、<400> 49
2051、met ala ala asp gly tyr leu pro asp trp leu glu asp asn leu ser
2052、1 5 10 15
2053、glu gly ile arg glu trp trp asp leu lys pro gly ala pro lys pro
2054、 20 25 30
2055、lys ala asn gln gln lys gln asp asp gly arg gly leu val leu pro
2056、 35 40 45
2057、gly tyr lys tyr leu gly pro phe asn gly leu asp lys gly glu pro
2058、 50 55 60
2059、val asn ala ala asp ala ala ala leu glu his asp lys ala tyr asp
2060、65 70 75 80
2061、gln gln leu lys ala gly asp asn pro tyr leu arg tyr asn his ala
2062、 85 90 95
2063、asp ala glu phe gln glu arg leu gln glu asp thr ser phe gly gly
2064、 100 105 110
2065、asn leu gly arg ala val phe gln ala lys lys arg val leu glu pro
2066、 115 120 125
2067、leu gly leu val glu glu gly ala lys thr ala pro gly lys lys arg
2068、 130 135 140
2069、pro val glu gln ser pro gln glu pro asp ser ser ser gly ile gly
2070、145 150 155 160
2071、lys thr gly gln gln pro ala lys lys arg leu asn phe gly gln thr
2072、 165 170 175
2073、gly asp thr glu ser val pro asp pro gln pro leu gly glu pro pro
2074、 180 185 190
2075、ala ala pro ser gly leu gly pro asn thr met ala ser gly gly gly
2076、 195 200 205
2077、ala pro met ala asp asn asn glu gly ala asp gly val gly asn ser
2078、 210 215 220
2079、ser gly asn trp his cys asp ser thr trp leu gly asp arg val ile
2080、225 230 235 240
2081、thr thr ser thr arg thr trp ala leu pro thr tyr asn asn his leu
2082、 245 250 255
2083、tyr lys gln ile ser asn gly thr ser gly gly ser thr asn asp asn
2084、 260 265 270
2085、thr tyr phe gly tyr ser thr pro trp gly tyr phe asp phe asn arg
2086、 275 280 285
2087、phe his cys his phe ser pro arg asp trp gln arg leu ile asn asn
2088、 290 295 300
2089、asn trp gly phe arg pro lys arg leu asn phe lys leu phe asn ile
2090、305 310 315 320
2091、gln val lys glu val thr thr asn glu gly thr lys thr ile ala asn
2092、 325 330 335
2093、asn leu thr ser thr val gln val phe thr asp ser glu tyr gln leu
2094、 340 345 350
2095、pro tyr val leu gly ser ala his gln gly cys leu pro pro phe pro
2096、 355 360 365
2097、ala asp val phe met val pro gln tyr gly tyr leu thr leu asn asn
2098、 370 375 380
2099、gly ser gln ala leu gly arg ser ser phe tyr cys leu glu tyr phe
2100、385 390 395 400
2101、pro ser gln met leu arg thr gly asn asn phe gln phe ser tyr thr
2102、 405 410 415
2103、phe glu asp val pro phe his ser ser tyr ala his ser gln ser leu
2104、 420 425 430
2105、asp arg leu met asn pro leu ile asp gln tyr leu tyr tyr leu val
2106、 435 440 445
2107、arg thr gln thr thr gly thr gly gly thr gln thr leu ala phe ser
2108、 450 455 460
2109、gln ala gly pro ser asn met ala ser gln ala arg asn trp val pro
2110、465 470 475 480
2111、gly pro ser tyr arg gln gln arg val ser thr thr thr asn gln asn
2112、 485 490 495
2113、asn asn ser asn phe ala trp thr gly ala ala lys phe lys leu asn
2114、 500 505 510
2115、gly arg asp ser leu met asn pro gly val ala met ala ser his lys
2116、 515 520 525
2117、asp asp glu asp arg phe phe pro ser ser gly val leu ile phe gly
2118、 530 535 540
2119、lys gln gly ala gly asn asp gly val asp tyr ser gln val leu ile
2120、545 550 555 560
2121、thr asp glu glu glu ile lys ala thr asn pro val ala thr glu glu
2122、 565 570 575
2123、tyr gly ala val ala ile asn asn gln ala ala asn thr gln ala gln
2124、 580 585 590
2125、thr gly leu val his asn gln gly val ile pro gly met val trp gln
2126、 595 600 605
2127、asn arg asp val tyr leu gln gly pro ile trp ala lys ile pro his
2128、 610 615 620
2129、thr asp gly asn phe his pro ser pro leu met gly gly phe gly leu
2130、625 630 635 640
2131、lys his pro pro pro gln ile leu ile lys asn thr pro val pro ala
2132、 645 650 655
2133、asp pro pro leu thr phe asn gln ala lys leu asn ser phe ile thr
2134、 660 665 670
2135、gln tyr ser thr gly gln val ser val glu ile glu trp glu leu gln
2136、 675 680 685
2137、lys glu asn ser lys arg trp asn pro glu ile gln tyr thr ser asn
2138、 690 695 700
2139、tyr tyr lys ser thr asn val asp phe ala val asn thr glu gly val
2140、705 710 715 720
2141、tyr ser glu pro arg pro ile gly thr arg tyr leu thr arg asn leu
2142、 725 730 735
2143、<210> 50
2144、<211> 228
2145、<212> prt
2146、<213> 人工序列
2147、<220>
2148、<223> 示例性igg-fc(2)
2149、<400> 50
2150、lys asp lys thr his thr cys pro pro cys pro ala pro glu leu leu
2151、1 5 10 15
2152、gly gly pro ser val phe leu phe pro pro lys pro lys asp thr leu
2153、 20 25 30
2154、met ile ser arg thr pro glu val thr cys val val val asp val ser
2155、 35 40 45
2156、his glu asp pro glu val lys phe asn trp tyr val asp gly val glu
2157、 50 55 60
2158、val his asn ala lys thr lys pro arg glu glu gln tyr asn ser thr
2159、65 70 75 80
2160、tyr arg val val ser val leu thr val leu his gln asp trp leu asn
2161、 85 90 95
2162、gly lys glu tyr lys cys lys val ser asn lys ala leu pro ala pro
2163、 100 105 110
2164、ile glu lys thr ile ser lys ala lys gly gln pro arg glu pro gln
2165、 115 120 125
2166、val tyr thr leu pro pro ser arg asp glu leu thr lys asn gln val
2167、 130 135 140
2168、ser leu thr cys leu val lys gly phe tyr pro ser asp ile ala val
2169、145 150 155 160
2170、glu trp glu ser asn gly gln pro glu asn asn tyr lys thr thr pro
2171、 165 170 175
2172、pro val leu asp ser asp gly ser phe phe leu tyr ser lys leu thr
2173、 180 185 190
2174、val asp lys ser arg trp gln gln gly asn val phe ser cys ser val
2175、 195 200 205
2176、met his glu ala leu his asn his tyr thr gln lys ser leu ser leu
2177、 210 215 220
2178、ser pro gly lys
2179、225
2180、<210> 51
2181、<211> 20
2182、<212> prt
2183、<213> 人工序列
2184、<220>
2185、<223> l1
2186、<400> 51
2187、lys phe asn pro leu asp glu leu glu glu thr leu tyr glu gln phe
2188、1 5 10 15
2189、thr phe gln gln
2190、 20
2191、<210> 52
2192、<211> 57
2193、<212> prt
2194、<213> 人工序列
2195、<220>
2196、<223> 示例性abd(2)(2xl1)
2197、<400> 52
2198、gly gly gly gly gly ala gln lys phe asn pro leu asp glu leu glu
2199、1 5 10 15
2200、glu thr leu tyr glu gln phe thr phe gln gln gly gly gly gly gly
2201、 20 25 30
2202、gly gly gly lys phe asn pro leu asp glu leu glu glu thr leu tyr
2203、 35 40 45
2204、glu gln phe thr phe gln gln leu glu
2205、 50 55
2206、<210> 53
2207、<211> 51
2208、<212> prt
2209、<213> 人工序列
2210、<220>
2211、<223> 示例性abd(3)(con4-l1)
2212、<400> 53
2213、gly gly gly gly gly ala gln gln glu glu cys glu trp asp pro trp
2214、1 5 10 15
2215、thr cys glu his met gly gly gly gly gly gly gly gly lys phe asn
2216、 20 25 30
2217、pro leu asp glu leu glu glu thr leu tyr glu gln phe thr phe gln
2218、 35 40 45
2219、gln leu glu
2220、 50
2221、<210> 54
2222、<211> 70
2223、<212> prt
2224、<213> 人工序列
2225、<220>
2226、<223> 示例性abd(4)(l1-con4)
2227、<400> 54
2228、gly gly gly gly gly ala gln gly ser gly ser ala thr gly gly ser
2229、1 5 10 15
2230、gly ser thr ala ser ser gly ser gly ser ala thr his lys phe asn
2231、 20 25 30
2232、pro leu asp glu leu glu glu thr leu tyr glu gln phe thr phe gln
2233、 35 40 45
2234、gln gly gly gly gly gly gln glu glu cys glu trp asp pro trp thr
2235、 50 55 60
2236、cys glu his met leu glu
2237、65 70
2238、<210> 55
2239、<211> 105
2240、<212> prt
2241、<213> 人工序列
2242、<220>
2243、<223> 来源于vegfr-2的示例性trap c(1)
2244、<400> 55
2245、val tyr val gln asp tyr arg ser pro phe ile ala ser val ser asp
2246、1 5 10 15
2247、gln his gly val val tyr ile thr glu asn lys asn lys thr val val
2248、 20 25 30
2249、ile pro cys leu gly ser ile ser asn leu asn val ser leu cys ala
2250、 35 40 45
2251、arg tyr pro glu lys arg phe val pro asp gly asn arg ile ser trp
2252、 50 55 60
2253、asp ser lys lys gly phe thr ile pro ser tyr met ile ser tyr ala
2254、65 70 75 80
2255、gly met val phe cys glu ala lys ile asn asp glu ser tyr gln ser
2256、 85 90 95
2257、ile met tyr ile val val val val gly
2258、 100 105
2259、<210> 56
2260、<211> 202
2261、<212> prt
2262、<213> 人工序列
2263、<220>
2264、<223> 来源于vegfr-3的示例性trap c(2)
2265、<400> 56
2266、tyr ser met thr pro pro thr leu asn ile thr glu glu ser his val
2267、1 5 10 15
2268、ile asp thr gly asp ser leu ser ile ser cys arg gly gln his pro
2269、 20 25 30
2270、leu glu trp ala trp pro gly ala gln glu ala pro ala thr gly asp
2271、 35 40 45
2272、lys asp ser glu asp thr gly val val arg asp cys glu gly thr asp
2273、 50 55 60
2274、ala arg pro tyr cys lys val leu leu leu his glu val his ala gln
2275、65 70 75 80
2276、asp thr gly ser tyr val cys tyr tyr lys tyr ile lys ala arg ile
2277、 85 90 95
2278、glu gly thr thr ala ala ser ser tyr val phe val arg asp phe glu
2279、 100 105 110
2280、gln pro phe ile asn lys pro asp thr leu leu val asn arg lys asp
2281、 115 120 125
2282、ala met trp val pro cys leu val ser ile pro gly leu asn val thr
2283、 130 135 140
2284、leu arg ser gln ser ser val leu trp pro asp gly gln glu val val
2285、145 150 155 160
2286、trp asp asp arg arg gly met leu val ser thr pro leu leu his asp
2287、 165 170 175
2288、ala leu tyr leu gln cys glu thr thr trp gly asp gln asp phe leu
2289、 180 185 190
2290、ser asn pro phe leu val his ile thr gly
2291、 195 200
2292、<210> 57
2293、<211> 202
2294、<212> prt
2295、<213> 人工序列
2296、<220>
2297、<223> 来源于vegfr-3的示例性trap c(3)
2298、<400> 57
2299、tyr ser met thr pro pro thr leu asn ile thr glu glu ser his val
2300、1 5 10 15
2301、ile asp thr gly asp ser leu ser ile ser cys arg gly gln his pro
2302、 20 25 30
2303、leu glu trp ala trp pro gly ala gln glu ala pro ala thr gly asp
2304、 35 40 45
2305、lys asp ser glu asp thr gly val val arg asp cys glu gly thr asp
2306、 50 55 60
2307、ala arg pro tyr cys lys val leu leu leu his glu val his ala asn
2308、65 70 75 80
2309、asp thr gly ser tyr val cys tyr tyr lys tyr ile lys ala arg ile
2310、 85 90 95
2311、glu gly thr thr ala ala ser ser tyr val phe val arg asp phe glu
2312、 100 105 110
2313、gln pro phe ile asn lys pro asp thr leu leu val asn arg lys asp
2314、 115 120 125
2315、ala met trp val pro cys leu val ser ile pro gly leu asn val thr
2316、 130 135 140
2317、leu arg ser gln ser ser val leu trp pro asp gly gln glu val val
2318、145 150 155 160
2319、trp asp asp arg arg gly met leu val ser thr pro leu leu his asp
2320、 165 170 175
2321、ala leu tyr leu gln cys glu thr thr trp gly asp gln asp phe leu
2322、 180 185 190
2323、ser asn pro phe leu val his ile thr gly
2324、 195 200
2325、<210> 58
2326、<211> 634
2327、<212> prt
2328、<213> 人工序列
2329、<220>
2330、<223> 示例性多肽5(如exg102-24中)
2331、<400> 58
2332、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2333、1 5 10 15
2334、cys leu leu leu thr gly ser ser ser gly gly gly gly gly gly ala
2335、 20 25 30
2336、gln gln glu glu cys glu trp asp pro trp thr cys glu his met gly
2337、 35 40 45
2338、ser gly ser ala thr gly gly ser gly ser thr ala ser ser gly ser
2339、 50 55 60
2340、gly ser ala thr his gln glu glu cys glu trp asp pro trp thr cys
2341、65 70 75 80
2342、glu his met leu glu gly gly gly gly gly ser ser asp thr gly arg
2343、 85 90 95
2344、pro phe val glu met tyr ser glu ile pro glu ile ile his met thr
2345、 100 105 110
2346、glu gly arg glu leu val ile pro cys arg val thr ser pro asn ile
2347、 115 120 125
2348、thr val thr leu lys lys phe pro leu asp thr leu ile pro asp gly
2349、 130 135 140
2350、lys arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala
2351、145 150 155 160
2352、thr tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly
2353、 165 170 175
2354、his leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile
2355、 180 185 190
2356、ile asp val val leu ser pro ser his gly ile glu leu ser val gly
2357、 195 200 205
2358、glu lys leu val leu asn cys thr ala arg thr glu leu asn val gly
2359、 210 215 220
2360、ile asp phe asn trp glu tyr pro ser ser lys his gln his lys lys
2361、225 230 235 240
2362、leu val asn arg asp leu lys thr gln ser gly ser glu met lys lys
2363、 245 250 255
2364、phe leu ser thr leu thr ile asp gly val thr arg ser asp gln gly
2365、 260 265 270
2366、leu tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser
2367、 275 280 285
2368、thr phe val arg val his glu lys gly gly gly gly gly ser val tyr
2369、 290 295 300
2370、val gln asp tyr arg ser pro phe ile ala ser val ser asp gln his
2371、305 310 315 320
2372、gly val val tyr ile thr glu asn lys asn lys thr val val ile pro
2373、 325 330 335
2374、cys leu gly ser ile ser asn leu asn val ser leu cys ala arg tyr
2375、 340 345 350
2376、pro glu lys arg phe val pro asp gly asn arg ile ser trp asp ser
2377、 355 360 365
2378、lys lys gly phe thr ile pro ser tyr met ile ser tyr ala gly met
2379、 370 375 380
2380、val phe cys glu ala lys ile asn asp glu ser tyr gln ser ile met
2381、385 390 395 400
2382、tyr ile val val val val gly asp lys thr his thr cys pro pro cys
2383、 405 410 415
2384、pro ala pro glu leu leu gly gly pro ser val phe leu phe pro pro
2385、 420 425 430
2386、lys pro lys asp thr leu met ile ser arg thr pro glu val thr cys
2387、 435 440 445
2388、val val val asp val ser his glu asp pro glu val lys phe asn trp
2389、 450 455 460
2390、tyr val asp gly val glu val his asn ala lys thr lys pro arg glu
2391、465 470 475 480
2392、glu gln tyr asn ser thr tyr arg val val ser val leu thr val leu
2393、 485 490 495
2394、his gln asp trp leu asn gly lys glu tyr lys cys lys val ser asn
2395、 500 505 510
2396、lys ala leu pro ala pro ile glu lys thr ile ser lys ala lys gly
2397、 515 520 525
2398、gln pro arg glu pro gln val tyr thr leu pro pro ser arg asp glu
2399、 530 535 540
2400、leu thr lys asn gln val ser leu thr cys leu val lys gly phe tyr
2401、545 550 555 560
2402、pro ser asp ile ala val glu trp glu ser asn gly gln pro glu asn
2403、 565 570 575
2404、asn tyr lys thr thr pro pro val leu asp ser asp gly ser phe phe
2405、 580 585 590
2406、leu tyr ser lys leu thr val asp lys ser arg trp gln gln gly asn
2407、 595 600 605
2408、val phe ser cys ser val met his glu ala leu his asn his tyr thr
2409、 610 615 620
2410、gln lys ser leu ser leu ser pro gly lys
2411、625 630
2412、<210> 59
2413、<211> 628
2414、<212> prt
2415、<213> 人工序列
2416、<220>
2417、<223> 示例性多肽6(如exg102-25中)
2418、<400> 59
2419、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2420、1 5 10 15
2421、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
2422、 20 25 30
2423、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
2424、 35 40 45
2425、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
2426、 50 55 60
2427、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
2428、65 70 75 80
2429、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
2430、 85 90 95
2431、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
2432、 100 105 110
2433、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
2434、 115 120 125
2435、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
2436、 130 135 140
2437、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
2438、145 150 155 160
2439、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
2440、 165 170 175
2441、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
2442、 180 185 190
2443、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
2444、 195 200 205
2445、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
2446、 210 215 220
2447、phe val arg val his glu lys gly gly gly gly gly ser val tyr val
2448、225 230 235 240
2449、gln asp tyr arg ser pro phe ile ala ser val ser asp gln his gly
2450、 245 250 255
2451、val val tyr ile thr glu asn lys asn lys thr val val ile pro cys
2452、 260 265 270
2453、leu gly ser ile ser asn leu asn val ser leu cys ala arg tyr pro
2454、 275 280 285
2455、glu lys arg phe val pro asp gly asn arg ile ser trp asp ser lys
2456、 290 295 300
2457、lys gly phe thr ile pro ser tyr met ile ser tyr ala gly met val
2458、305 310 315 320
2459、phe cys glu ala lys ile asn asp glu ser tyr gln ser ile met tyr
2460、 325 330 335
2461、ile val val val val gly asp lys thr his thr cys pro pro cys pro
2462、 340 345 350
2463、ala pro glu leu leu gly gly pro ser val phe leu phe pro pro lys
2464、 355 360 365
2465、pro lys asp thr leu met ile ser arg thr pro glu val thr cys val
2466、 370 375 380
2467、val val asp val ser his glu asp pro glu val lys phe asn trp tyr
2468、385 390 395 400
2469、val asp gly val glu val his asn ala lys thr lys pro arg glu glu
2470、 405 410 415
2471、gln tyr asn ser thr tyr arg val val ser val leu thr val leu his
2472、 420 425 430
2473、gln asp trp leu asn gly lys glu tyr lys cys lys val ser asn lys
2474、 435 440 445
2475、ala leu pro ala pro ile glu lys thr ile ser lys ala lys gly gln
2476、 450 455 460
2477、pro arg glu pro gln val tyr thr leu pro pro ser arg asp glu leu
2478、465 470 475 480
2479、thr lys asn gln val ser leu thr cys leu val lys gly phe tyr pro
2480、 485 490 495
2481、ser asp ile ala val glu trp glu ser asn gly gln pro glu asn asn
2482、 500 505 510
2483、tyr lys thr thr pro pro val leu asp ser asp gly ser phe phe leu
2484、 515 520 525
2485、tyr ser lys leu thr val asp lys ser arg trp gln gln gly asn val
2486、 530 535 540
2487、phe ser cys ser val met his glu ala leu his asn his tyr thr gln
2488、545 550 555 560
2489、lys ser leu ser leu ser pro gly lys gly gly gly gly gly ala gln
2490、 565 570 575
2491、gln glu glu cys glu trp asp pro trp thr cys glu his met gly ser
2492、 580 585 590
2493、gly ser ala thr gly gly ser gly ser thr ala ser ser gly ser gly
2494、 595 600 605
2495、ser ala thr his gln glu glu cys glu trp asp pro trp thr cys glu
2496、 610 615 620
2497、his met leu glu
2498、625
2499、<210> 60
2500、<211> 639
2501、<212> prt
2502、<213> 人工序列
2503、<220>
2504、<223> 示例性多肽7(如exg102-26中)
2505、<400> 60
2506、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2507、1 5 10 15
2508、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
2509、 20 25 30
2510、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
2511、 35 40 45
2512、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
2513、 50 55 60
2514、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
2515、65 70 75 80
2516、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
2517、 85 90 95
2518、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
2519、 100 105 110
2520、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
2521、 115 120 125
2522、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
2523、 130 135 140
2524、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
2525、145 150 155 160
2526、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
2527、 165 170 175
2528、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
2529、 180 185 190
2530、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
2531、 195 200 205
2532、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
2533、 210 215 220
2534、phe val arg val his glu lys gly gly gly gly gly ser val tyr val
2535、225 230 235 240
2536、gln asp tyr arg ser pro phe ile ala ser val ser asp gln his gly
2537、 245 250 255
2538、val val tyr ile thr glu asn lys asn lys thr val val ile pro cys
2539、 260 265 270
2540、leu gly ser ile ser asn leu asn val ser leu cys ala arg tyr pro
2541、 275 280 285
2542、glu lys arg phe val pro asp gly asn arg ile ser trp asp ser lys
2543、 290 295 300
2544、lys gly phe thr ile pro ser tyr met ile ser tyr ala gly met val
2545、305 310 315 320
2546、phe cys glu ala lys ile asn asp glu ser tyr gln ser ile met tyr
2547、 325 330 335
2548、ile val val val val gly asp lys thr his thr cys pro pro cys pro
2549、 340 345 350
2550、ala pro glu leu leu gly gly pro ser val phe leu phe pro pro lys
2551、 355 360 365
2552、pro lys asp thr leu met ile ser arg thr pro glu val thr cys val
2553、 370 375 380
2554、val val asp val ser his glu asp pro glu val lys phe asn trp tyr
2555、385 390 395 400
2556、val asp gly val glu val his asn ala lys thr lys pro arg glu glu
2557、 405 410 415
2558、gln tyr asn ser thr tyr arg val val ser val leu thr val leu his
2559、 420 425 430
2560、gln asp trp leu asn gly lys glu tyr lys cys lys val ser asn lys
2561、 435 440 445
2562、ala leu pro ala pro ile glu lys thr ile ser lys ala lys gly gln
2563、 450 455 460
2564、pro arg glu pro gln val tyr thr leu pro pro ser arg asp glu leu
2565、465 470 475 480
2566、thr lys asn gln val ser leu thr cys leu val lys gly phe tyr pro
2567、 485 490 495
2568、ser asp ile ala val glu trp glu ser asn gly gln pro glu asn asn
2569、 500 505 510
2570、tyr lys thr thr pro pro val leu asp ser asp gly ser phe phe leu
2571、 515 520 525
2572、tyr ser lys leu thr val asp lys ser arg trp gln gln gly asn val
2573、 530 535 540
2574、phe ser cys ser val met his glu ala leu his asn his tyr thr gln
2575、545 550 555 560
2576、lys ser leu ser leu ser pro gly lys gly gly gly gly gly ala gln
2577、 565 570 575
2578、gly ser gly ser ala thr gly gly ser gly ser thr ala ser ser gly
2579、 580 585 590
2580、ser gly ser ala thr his lys phe asn pro leu asp glu leu glu glu
2581、 595 600 605
2582、thr leu tyr glu gln phe thr phe gln gln gly gly gly gly gly gln
2583、 610 615 620
2584、glu glu cys glu trp asp pro trp thr cys glu his met leu glu
2585、625 630 635
2586、<210> 61
2587、<211> 731
2588、<212> prt
2589、<213> 人工序列
2590、<220>
2591、<223> 示例性多肽8(如exg102-27中)
2592、<400> 61
2593、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2594、1 5 10 15
2595、cys leu leu leu thr gly ser ser ser gly gly gly gly gly gly ala
2596、 20 25 30
2597、gln gln glu glu cys glu trp asp pro trp thr cys glu his met gly
2598、 35 40 45
2599、ser gly ser ala thr gly gly ser gly ser thr ala ser ser gly ser
2600、 50 55 60
2601、gly ser ala thr his gln glu glu cys glu trp asp pro trp thr cys
2602、65 70 75 80
2603、glu his met leu glu gly gly gly gly gly ser ser asp thr gly arg
2604、 85 90 95
2605、pro phe val glu met tyr ser glu ile pro glu ile ile his met thr
2606、 100 105 110
2607、glu gly arg glu leu val ile pro cys arg val thr ser pro asn ile
2608、 115 120 125
2609、thr val thr leu lys lys phe pro leu asp thr leu ile pro asp gly
2610、 130 135 140
2611、lys arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala
2612、145 150 155 160
2613、thr tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly
2614、 165 170 175
2615、his leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile
2616、 180 185 190
2617、ile asp val val leu ser pro ser his gly ile glu leu ser val gly
2618、 195 200 205
2619、glu lys leu val leu asn cys thr ala arg thr glu leu asn val gly
2620、 210 215 220
2621、ile asp phe asn trp glu tyr pro ser ser lys his gln his lys lys
2622、225 230 235 240
2623、leu val asn arg asp leu lys thr gln ser gly ser glu met lys lys
2624、 245 250 255
2625、phe leu ser thr leu thr ile asp gly val thr arg ser asp gln gly
2626、 260 265 270
2627、leu tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser
2628、 275 280 285
2629、thr phe val arg val his glu lys gly gly gly gly gly ser tyr ser
2630、 290 295 300
2631、met thr pro pro thr leu asn ile thr glu glu ser his val ile asp
2632、305 310 315 320
2633、thr gly asp ser leu ser ile ser cys arg gly gln his pro leu glu
2634、 325 330 335
2635、trp ala trp pro gly ala gln glu ala pro ala thr gly asp lys asp
2636、 340 345 350
2637、ser glu asp thr gly val val arg asp cys glu gly thr asp ala arg
2638、 355 360 365
2639、pro tyr cys lys val leu leu leu his glu val his ala gln asp thr
2640、 370 375 380
2641、gly ser tyr val cys tyr tyr lys tyr ile lys ala arg ile glu gly
2642、385 390 395 400
2643、thr thr ala ala ser ser tyr val phe val arg asp phe glu gln pro
2644、 405 410 415
2645、phe ile asn lys pro asp thr leu leu val asn arg lys asp ala met
2646、 420 425 430
2647、trp val pro cys leu val ser ile pro gly leu asn val thr leu arg
2648、 435 440 445
2649、ser gln ser ser val leu trp pro asp gly gln glu val val trp asp
2650、 450 455 460
2651、asp arg arg gly met leu val ser thr pro leu leu his asp ala leu
2652、465 470 475 480
2653、tyr leu gln cys glu thr thr trp gly asp gln asp phe leu ser asn
2654、 485 490 495
2655、pro phe leu val his ile thr gly asp lys thr his thr cys pro pro
2656、 500 505 510
2657、cys pro ala pro glu leu leu gly gly pro ser val phe leu phe pro
2658、 515 520 525
2659、pro lys pro lys asp thr leu met ile ser arg thr pro glu val thr
2660、 530 535 540
2661、cys val val val asp val ser his glu asp pro glu val lys phe asn
2662、545 550 555 560
2663、trp tyr val asp gly val glu val his asn ala lys thr lys pro arg
2664、 565 570 575
2665、glu glu gln tyr asn ser thr tyr arg val val ser val leu thr val
2666、 580 585 590
2667、leu his gln asp trp leu asn gly lys glu tyr lys cys lys val ser
2668、 595 600 605
2669、asn lys ala leu pro ala pro ile glu lys thr ile ser lys ala lys
2670、 610 615 620
2671、gly gln pro arg glu pro gln val tyr thr leu pro pro ser arg asp
2672、625 630 635 640
2673、glu leu thr lys asn gln val ser leu thr cys leu val lys gly phe
2674、 645 650 655
2675、tyr pro ser asp ile ala val glu trp glu ser asn gly gln pro glu
2676、 660 665 670
2677、asn asn tyr lys thr thr pro pro val leu asp ser asp gly ser phe
2678、 675 680 685
2679、phe leu tyr ser lys leu thr val asp lys ser arg trp gln gln gly
2680、 690 695 700
2681、asn val phe ser cys ser val met his glu ala leu his asn his tyr
2682、705 710 715 720
2683、thr gln lys ser leu ser leu ser pro gly lys
2684、 725 730
2685、<210> 62
2686、<211> 725
2687、<212> prt
2688、<213> 人工序列
2689、<220>
2690、<223> 示例性多肽9(如exg102-28中)
2691、<400> 62
2692、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2693、1 5 10 15
2694、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
2695、 20 25 30
2696、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
2697、 35 40 45
2698、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
2699、 50 55 60
2700、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
2701、65 70 75 80
2702、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
2703、 85 90 95
2704、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
2705、 100 105 110
2706、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
2707、 115 120 125
2708、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
2709、 130 135 140
2710、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
2711、145 150 155 160
2712、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
2713、 165 170 175
2714、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
2715、 180 185 190
2716、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
2717、 195 200 205
2718、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
2719、 210 215 220
2720、phe val arg val his glu lys gly gly gly gly gly ser tyr ser met
2721、225 230 235 240
2722、thr pro pro thr leu asn ile thr glu glu ser his val ile asp thr
2723、 245 250 255
2724、gly asp ser leu ser ile ser cys arg gly gln his pro leu glu trp
2725、 260 265 270
2726、ala trp pro gly ala gln glu ala pro ala thr gly asp lys asp ser
2727、 275 280 285
2728、glu asp thr gly val val arg asp cys glu gly thr asp ala arg pro
2729、 290 295 300
2730、tyr cys lys val leu leu leu his glu val his ala gln asp thr gly
2731、305 310 315 320
2732、ser tyr val cys tyr tyr lys tyr ile lys ala arg ile glu gly thr
2733、 325 330 335
2734、thr ala ala ser ser tyr val phe val arg asp phe glu gln pro phe
2735、 340 345 350
2736、ile asn lys pro asp thr leu leu val asn arg lys asp ala met trp
2737、 355 360 365
2738、val pro cys leu val ser ile pro gly leu asn val thr leu arg ser
2739、 370 375 380
2740、gln ser ser val leu trp pro asp gly gln glu val val trp asp asp
2741、385 390 395 400
2742、arg arg gly met leu val ser thr pro leu leu his asp ala leu tyr
2743、 405 410 415
2744、leu gln cys glu thr thr trp gly asp gln asp phe leu ser asn pro
2745、 420 425 430
2746、phe leu val his ile thr gly asp lys thr his thr cys pro pro cys
2747、 435 440 445
2748、pro ala pro glu leu leu gly gly pro ser val phe leu phe pro pro
2749、 450 455 460
2750、lys pro lys asp thr leu met ile ser arg thr pro glu val thr cys
2751、465 470 475 480
2752、val val val asp val ser his glu asp pro glu val lys phe asn trp
2753、 485 490 495
2754、tyr val asp gly val glu val his asn ala lys thr lys pro arg glu
2755、 500 505 510
2756、glu gln tyr asn ser thr tyr arg val val ser val leu thr val leu
2757、 515 520 525
2758、his gln asp trp leu asn gly lys glu tyr lys cys lys val ser asn
2759、 530 535 540
2760、lys ala leu pro ala pro ile glu lys thr ile ser lys ala lys gly
2761、545 550 555 560
2762、gln pro arg glu pro gln val tyr thr leu pro pro ser arg asp glu
2763、 565 570 575
2764、leu thr lys asn gln val ser leu thr cys leu val lys gly phe tyr
2765、 580 585 590
2766、pro ser asp ile ala val glu trp glu ser asn gly gln pro glu asn
2767、 595 600 605
2768、asn tyr lys thr thr pro pro val leu asp ser asp gly ser phe phe
2769、 610 615 620
2770、leu tyr ser lys leu thr val asp lys ser arg trp gln gln gly asn
2771、625 630 635 640
2772、val phe ser cys ser val met his glu ala leu his asn his tyr thr
2773、 645 650 655
2774、gln lys ser leu ser leu ser pro gly lys gly gly gly gly gly ala
2775、 660 665 670
2776、gln gln glu glu cys glu trp asp pro trp thr cys glu his met gly
2777、 675 680 685
2778、ser gly ser ala thr gly gly ser gly ser thr ala ser ser gly ser
2779、 690 695 700
2780、gly ser ala thr his gln glu glu cys glu trp asp pro trp thr cys
2781、705 710 715 720
2782、glu his met leu glu
2783、 725
2784、<210> 63
2785、<211> 736
2786、<212> prt
2787、<213> 人工序列
2788、<220>
2789、<223> 示例性多肽10(如exg102-29中)
2790、<400> 63
2791、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2792、1 5 10 15
2793、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
2794、 20 25 30
2795、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
2796、 35 40 45
2797、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
2798、 50 55 60
2799、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
2800、65 70 75 80
2801、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
2802、 85 90 95
2803、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
2804、 100 105 110
2805、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
2806、 115 120 125
2807、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
2808、 130 135 140
2809、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
2810、145 150 155 160
2811、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
2812、 165 170 175
2813、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
2814、 180 185 190
2815、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
2816、 195 200 205
2817、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
2818、 210 215 220
2819、phe val arg val his glu lys gly gly gly gly gly ser tyr ser met
2820、225 230 235 240
2821、thr pro pro thr leu asn ile thr glu glu ser his val ile asp thr
2822、 245 250 255
2823、gly asp ser leu ser ile ser cys arg gly gln his pro leu glu trp
2824、 260 265 270
2825、ala trp pro gly ala gln glu ala pro ala thr gly asp lys asp ser
2826、 275 280 285
2827、glu asp thr gly val val arg asp cys glu gly thr asp ala arg pro
2828、 290 295 300
2829、tyr cys lys val leu leu leu his glu val his ala gln asp thr gly
2830、305 310 315 320
2831、ser tyr val cys tyr tyr lys tyr ile lys ala arg ile glu gly thr
2832、 325 330 335
2833、thr ala ala ser ser tyr val phe val arg asp phe glu gln pro phe
2834、 340 345 350
2835、ile asn lys pro asp thr leu leu val asn arg lys asp ala met trp
2836、 355 360 365
2837、val pro cys leu val ser ile pro gly leu asn val thr leu arg ser
2838、 370 375 380
2839、gln ser ser val leu trp pro asp gly gln glu val val trp asp asp
2840、385 390 395 400
2841、arg arg gly met leu val ser thr pro leu leu his asp ala leu tyr
2842、 405 410 415
2843、leu gln cys glu thr thr trp gly asp gln asp phe leu ser asn pro
2844、 420 425 430
2845、phe leu val his ile thr gly asp lys thr his thr cys pro pro cys
2846、 435 440 445
2847、pro ala pro glu leu leu gly gly pro ser val phe leu phe pro pro
2848、 450 455 460
2849、lys pro lys asp thr leu met ile ser arg thr pro glu val thr cys
2850、465 470 475 480
2851、val val val asp val ser his glu asp pro glu val lys phe asn trp
2852、 485 490 495
2853、tyr val asp gly val glu val his asn ala lys thr lys pro arg glu
2854、 500 505 510
2855、glu gln tyr asn ser thr tyr arg val val ser val leu thr val leu
2856、 515 520 525
2857、his gln asp trp leu asn gly lys glu tyr lys cys lys val ser asn
2858、 530 535 540
2859、lys ala leu pro ala pro ile glu lys thr ile ser lys ala lys gly
2860、545 550 555 560
2861、gln pro arg glu pro gln val tyr thr leu pro pro ser arg asp glu
2862、 565 570 575
2863、leu thr lys asn gln val ser leu thr cys leu val lys gly phe tyr
2864、 580 585 590
2865、pro ser asp ile ala val glu trp glu ser asn gly gln pro glu asn
2866、 595 600 605
2867、asn tyr lys thr thr pro pro val leu asp ser asp gly ser phe phe
2868、 610 615 620
2869、leu tyr ser lys leu thr val asp lys ser arg trp gln gln gly asn
2870、625 630 635 640
2871、val phe ser cys ser val met his glu ala leu his asn his tyr thr
2872、 645 650 655
2873、gln lys ser leu ser leu ser pro gly lys gly gly gly gly gly ala
2874、 660 665 670
2875、gln gly ser gly ser ala thr gly gly ser gly ser thr ala ser ser
2876、 675 680 685
2877、gly ser gly ser ala thr his lys phe asn pro leu asp glu leu glu
2878、 690 695 700
2879、glu thr leu tyr glu gln phe thr phe gln gln gly gly gly gly gly
2880、705 710 715 720
2881、gln glu glu cys glu trp asp pro trp thr cys glu his met leu glu
2882、 725 730 735
2883、<210> 64
2884、<211> 534
2885、<212> prt
2886、<213> 人工序列
2887、<220>
2888、<223> 示例性多肽11(如exg102-30中)
2889、<400> 64
2890、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2891、1 5 10 15
2892、cys leu leu leu thr gly ser ser ser gly gly gly gly gly gly ala
2893、 20 25 30
2894、gln gly ser gly ser ala thr gly gly ser gly ser thr ala ser ser
2895、 35 40 45
2896、gly ser gly ser ala thr his lys phe asn pro leu asp glu leu glu
2897、 50 55 60
2898、glu thr leu tyr glu gln phe thr phe gln gln gly gly gly gly gly
2899、65 70 75 80
2900、gln glu glu cys glu trp asp pro trp thr cys glu his met leu glu
2901、 85 90 95
2902、gly gly gly gly gly ser ser asp thr gly arg pro phe val glu met
2903、 100 105 110
2904、tyr ser glu ile pro glu ile ile his met thr glu gly arg glu leu
2905、 115 120 125
2906、val ile pro cys arg val thr ser pro asn ile thr val thr leu lys
2907、 130 135 140
2908、lys phe pro leu asp thr leu ile pro asp gly lys arg ile ile trp
2909、145 150 155 160
2910、asp ser arg lys gly phe ile ile ser asn ala thr tyr lys glu ile
2911、 165 170 175
2912、gly leu leu thr cys glu ala thr val asn gly his leu tyr lys thr
2913、 180 185 190
2914、asn tyr leu thr his arg gln thr asn thr ile ile asp val val leu
2915、 195 200 205
2916、ser pro ser his gly ile glu leu ser val gly glu lys leu val leu
2917、 210 215 220
2918、asn cys thr ala arg thr glu leu asn val gly ile asp phe asn trp
2919、225 230 235 240
2920、glu tyr pro ser ser lys his gln his lys lys leu val asn arg asp
2921、 245 250 255
2922、leu lys thr gln ser gly ser glu met lys lys phe leu ser thr leu
2923、 260 265 270
2924、thr ile asp gly val thr arg ser asp gln gly leu tyr thr cys ala
2925、 275 280 285
2926、ala ser ser gly leu met thr lys lys asn ser thr phe val arg val
2927、 290 295 300
2928、his glu lys asp lys thr his thr cys pro pro cys pro ala pro glu
2929、305 310 315 320
2930、leu leu gly gly pro ser val phe leu phe pro pro lys pro lys asp
2931、 325 330 335
2932、thr leu met ile ser arg thr pro glu val thr cys val val val asp
2933、 340 345 350
2934、val ser his glu asp pro glu val lys phe asn trp tyr val asp gly
2935、 355 360 365
2936、val glu val his asn ala lys thr lys pro arg glu glu gln tyr asn
2937、 370 375 380
2938、ser thr tyr arg val val ser val leu thr val leu his gln asp trp
2939、385 390 395 400
2940、leu asn gly lys glu tyr lys cys lys val ser asn lys ala leu pro
2941、 405 410 415
2942、ala pro ile glu lys thr ile ser lys ala lys gly gln pro arg glu
2943、 420 425 430
2944、pro gln val tyr thr leu pro pro ser arg asp glu leu thr lys asn
2945、 435 440 445
2946、gln val ser leu thr cys leu val lys gly phe tyr pro ser asp ile
2947、 450 455 460
2948、ala val glu trp glu ser asn gly gln pro glu asn asn tyr lys thr
2949、465 470 475 480
2950、thr pro pro val leu asp ser asp gly ser phe phe leu tyr ser lys
2951、 485 490 495
2952、leu thr val asp lys ser arg trp gln gln gly asn val phe ser cys
2953、 500 505 510
2954、ser val met his glu ala leu his asn his tyr thr gln lys ser leu
2955、 515 520 525
2956、ser leu ser pro gly lys
2957、 530
2958、<210> 65
2959、<211> 742
2960、<212> prt
2961、<213> 人工序列
2962、<220>
2963、<223> 示例性多肽12(如exg102-31中)
2964、<400> 65
2965、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
2966、1 5 10 15
2967、cys leu leu leu thr gly ser ser ser gly gly gly gly gly gly ala
2968、 20 25 30
2969、gln gly ser gly ser ala thr gly gly ser gly ser thr ala ser ser
2970、 35 40 45
2971、gly ser gly ser ala thr his lys phe asn pro leu asp glu leu glu
2972、 50 55 60
2973、glu thr leu tyr glu gln phe thr phe gln gln gly gly gly gly gly
2974、65 70 75 80
2975、gln glu glu cys glu trp asp pro trp thr cys glu his met leu glu
2976、 85 90 95
2977、gly gly gly gly gly ser ser asp thr gly arg pro phe val glu met
2978、 100 105 110
2979、tyr ser glu ile pro glu ile ile his met thr glu gly arg glu leu
2980、 115 120 125
2981、val ile pro cys arg val thr ser pro asn ile thr val thr leu lys
2982、 130 135 140
2983、lys phe pro leu asp thr leu ile pro asp gly lys arg ile ile trp
2984、145 150 155 160
2985、asp ser arg lys gly phe ile ile ser asn ala thr tyr lys glu ile
2986、 165 170 175
2987、gly leu leu thr cys glu ala thr val asn gly his leu tyr lys thr
2988、 180 185 190
2989、asn tyr leu thr his arg gln thr asn thr ile ile asp val val leu
2990、 195 200 205
2991、ser pro ser his gly ile glu leu ser val gly glu lys leu val leu
2992、 210 215 220
2993、asn cys thr ala arg thr glu leu asn val gly ile asp phe asn trp
2994、225 230 235 240
2995、glu tyr pro ser ser lys his gln his lys lys leu val asn arg asp
2996、 245 250 255
2997、leu lys thr gln ser gly ser glu met lys lys phe leu ser thr leu
2998、 260 265 270
2999、thr ile asp gly val thr arg ser asp gln gly leu tyr thr cys ala
3000、 275 280 285
3001、ala ser ser gly leu met thr lys lys asn ser thr phe val arg val
3002、 290 295 300
3003、his glu lys gly gly gly gly gly ser tyr ser met thr pro pro thr
3004、305 310 315 320
3005、leu asn ile thr glu glu ser his val ile asp thr gly asp ser leu
3006、 325 330 335
3007、ser ile ser cys arg gly gln his pro leu glu trp ala trp pro gly
3008、 340 345 350
3009、ala gln glu ala pro ala thr gly asp lys asp ser glu asp thr gly
3010、 355 360 365
3011、val val arg asp cys glu gly thr asp ala arg pro tyr cys lys val
3012、 370 375 380
3013、leu leu leu his glu val his ala asn asp thr gly ser tyr val cys
3014、385 390 395 400
3015、tyr tyr lys tyr ile lys ala arg ile glu gly thr thr ala ala ser
3016、 405 410 415
3017、ser tyr val phe val arg asp phe glu gln pro phe ile asn lys pro
3018、 420 425 430
3019、asp thr leu leu val asn arg lys asp ala met trp val pro cys leu
3020、 435 440 445
3021、val ser ile pro gly leu asn val thr leu arg ser gln ser ser val
3022、 450 455 460
3023、leu trp pro asp gly gln glu val val trp asp asp arg arg gly met
3024、465 470 475 480
3025、leu val ser thr pro leu leu his asp ala leu tyr leu gln cys glu
3026、 485 490 495
3027、thr thr trp gly asp gln asp phe leu ser asn pro phe leu val his
3028、 500 505 510
3029、ile thr gly asp lys thr his thr cys pro pro cys pro ala pro glu
3030、 515 520 525
3031、leu leu gly gly pro ser val phe leu phe pro pro lys pro lys asp
3032、 530 535 540
3033、thr leu met ile ser arg thr pro glu val thr cys val val val asp
3034、545 550 555 560
3035、val ser his glu asp pro glu val lys phe asn trp tyr val asp gly
3036、 565 570 575
3037、val glu val his asn ala lys thr lys pro arg glu glu gln tyr asn
3038、 580 585 590
3039、ser thr tyr arg val val ser val leu thr val leu his gln asp trp
3040、 595 600 605
3041、leu asn gly lys glu tyr lys cys lys val ser asn lys ala leu pro
3042、 610 615 620
3043、ala pro ile glu lys thr ile ser lys ala lys gly gln pro arg glu
3044、625 630 635 640
3045、pro gln val tyr thr leu pro pro ser arg asp glu leu thr lys asn
3046、 645 650 655
3047、gln val ser leu thr cys leu val lys gly phe tyr pro ser asp ile
3048、 660 665 670
3049、ala val glu trp glu ser asn gly gln pro glu asn asn tyr lys thr
3050、 675 680 685
3051、thr pro pro val leu asp ser asp gly ser phe phe leu tyr ser lys
3052、 690 695 700
3053、leu thr val asp lys ser arg trp gln gln gly asn val phe ser cys
3054、705 710 715 720
3055、ser val met his glu ala leu his asn his tyr thr gln lys ser leu
3056、 725 730 735
3057、ser leu ser pro gly lys
3058、 740
3059、<210> 66
3060、<211> 736
3061、<212> prt
3062、<213> 人工序列
3063、<220>
3064、<223> 示例性多肽13(如exg102-32中)
3065、<400> 66
3066、met val ser tyr trp asp thr gly val leu leu cys ala leu leu ser
3067、1 5 10 15
3068、cys leu leu leu thr gly ser ser ser gly ser asp thr gly arg pro
3069、 20 25 30
3070、phe val glu met tyr ser glu ile pro glu ile ile his met thr glu
3071、 35 40 45
3072、gly arg glu leu val ile pro cys arg val thr ser pro asn ile thr
3073、 50 55 60
3074、val thr leu lys lys phe pro leu asp thr leu ile pro asp gly lys
3075、65 70 75 80
3076、arg ile ile trp asp ser arg lys gly phe ile ile ser asn ala thr
3077、 85 90 95
3078、tyr lys glu ile gly leu leu thr cys glu ala thr val asn gly his
3079、 100 105 110
3080、leu tyr lys thr asn tyr leu thr his arg gln thr asn thr ile ile
3081、 115 120 125
3082、asp val val leu ser pro ser his gly ile glu leu ser val gly glu
3083、 130 135 140
3084、lys leu val leu asn cys thr ala arg thr glu leu asn val gly ile
3085、145 150 155 160
3086、asp phe asn trp glu tyr pro ser ser lys his gln his lys lys leu
3087、 165 170 175
3088、val asn arg asp leu lys thr gln ser gly ser glu met lys lys phe
3089、 180 185 190
3090、leu ser thr leu thr ile asp gly val thr arg ser asp gln gly leu
3091、 195 200 205
3092、tyr thr cys ala ala ser ser gly leu met thr lys lys asn ser thr
3093、 210 215 220
3094、phe val arg val his glu lys gly gly gly gly gly ser tyr ser met
3095、225 230 235 240
3096、thr pro pro thr leu asn ile thr glu glu ser his val ile asp thr
3097、 245 250 255
3098、gly asp ser leu ser ile ser cys arg gly gln his pro leu glu trp
3099、 260 265 270
3100、ala trp pro gly ala gln glu ala pro ala thr gly asp lys asp ser
3101、 275 280 285
3102、glu asp thr gly val val arg asp cys glu gly thr asp ala arg pro
3103、 290 295 300
3104、tyr cys lys val leu leu leu his glu val his ala asn asp thr gly
3105、305 310 315 320
3106、ser tyr val cys tyr tyr lys tyr ile lys ala arg ile glu gly thr
3107、 325 330 335
3108、thr ala ala ser ser tyr val phe val arg asp phe glu gln pro phe
3109、 340 345 350
3110、ile asn lys pro asp thr leu leu val asn arg lys asp ala met trp
3111、 355 360 365
3112、val pro cys leu val ser ile pro gly leu asn val thr leu arg ser
3113、 370 375 380
3114、gln ser ser val leu trp pro asp gly gln glu val val trp asp asp
3115、385 390 395 400
3116、arg arg gly met leu val ser thr pro leu leu his asp ala leu tyr
3117、 405 410 415
3118、leu gln cys glu thr thr trp gly asp gln asp phe leu ser asn pro
3119、 420 425 430
3120、phe leu val his ile thr gly asp lys thr his thr cys pro pro cys
3121、 435 440 445
3122、pro ala pro glu leu leu gly gly pro ser val phe leu phe pro pro
3123、 450 455 460
3124、lys pro lys asp thr leu met ile ser arg thr pro glu val thr cys
3125、465 470 475 480
3126、val val val asp val ser his glu asp pro glu val lys phe asn trp
3127、 485 490 495
3128、tyr val asp gly val glu val his asn ala lys thr lys pro arg glu
3129、 500 505 510
3130、glu gln tyr asn ser thr tyr arg val val ser val leu thr val leu
3131、 515 520 525
3132、his gln asp trp leu asn gly lys glu tyr lys cys lys val ser asn
3133、 530 535 540
3134、lys ala leu pro ala pro ile glu lys thr ile ser lys ala lys gly
3135、545 550 555 560
3136、gln pro arg glu pro gln val tyr thr leu pro pro ser arg asp glu
3137、 565 570 575
3138、leu thr lys asn gln val ser leu thr cys leu val lys gly phe tyr
3139、 580 585 590
3140、pro ser asp ile ala val glu trp glu ser asn gly gln pro glu asn
3141、 595 600 605
3142、asn tyr lys thr thr pro pro val leu asp ser asp gly ser phe phe
3143、 610 615 620
3144、leu tyr ser lys leu thr val asp lys ser arg trp gln gln gly asn
3145、625 630 635 640
3146、val phe ser cys ser val met his glu ala leu his asn his tyr thr
3147、 645 650 655
3148、gln lys ser leu ser leu ser pro gly lys gly gly gly gly gly ala
3149、 660 665 670
3150、gln gly ser gly ser ala thr gly gly ser gly ser thr ala ser ser
3151、 675 680 685
3152、gly ser gly ser ala thr his lys phe asn pro leu asp glu leu glu
3153、 690 695 700
3154、glu thr leu tyr glu gln phe thr phe gln gln gly gly gly gly gly
3155、705 710 715 720
3156、gln glu glu cys glu trp asp pro trp thr cys glu his met leu glu
3157、 725 730 735
3158、<210> 67
3159、<211> 1905
3160、<212> dna
3161、<213> 人工序列
3162、<220>
3163、<223> 示例性多肽5的核酸(如exg102-24中)
3164、<400> 67
3165、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3166、actggttctt cttctggggg cggcggcgga ggcgcccagc aagaagagtg cgagtgggat 120
3167、ccctggacct gcgagcacat gggatccggc agcgccaccg gaggatccgg aagcaccgcc 180
3168、tccagcggct ccggcagcgc cacccaccag gaggagtgtg agtgggaccc ctggacctgc 240
3169、gaacacatgc tggagggcgg cggcggaggc agctccgata ctgggcgccc cttcgtggag 300
3170、atgtactccg agatccctga aatcattcac atgactgagg gtcgggaact ggtcatccca 360
3171、tgccgcgtga cctctcccaa cattactgtg accctgaaga aattccctct ggacaccctc 420
3172、atcccagatg ggaagaggat catttgggac tcaagaaagg gttttatcat cagcaacgct 480
3173、acatacaagg agattggcct gctcacctgc gaagcaacag tgaacggaca cctgtacaag 540
3174、actaattatc tcacccatag acagacaaac actatcattg atgtggtcct gtcaccaagc 600
3175、cacggcatcg agctcagcgt cggtgaaaag ctggtgctca attgtacagc ccggactgag 660
3176、ctgaacgtgg gcattgactt caattgggaa taccccagct ccaagcacca gcataagaaa 720
3177、ctggtgaacc gcgatctcaa aacccagtcc ggatctgaga tgaagaaatt tctgagcacc 780
3178、ctcacaatcg acggcgtgac acgatccgat cagggactgt atacttgcgc cgcttctagt 840
3179、ggcctgatga ccaagaaaaa tagcacattc gtcagggtgc acgaaaaggg cggcggcgga 900
3180、ggcagcgtgt acgtgcaaga ctacagaagc cccttcatcg ctagcgtgag cgatcagcac 960
3181、ggcgtggtgt acatcaccga gaacaagaac aagaccgtgg tgatcccctg cctgggcagc 1020
3182、atcagcaacc tgaacgtgag cctgtgcgct agataccccg agaagagatt cgtgcccgac 1080
3183、ggcaacagaa tcagctggga cagcaagaag ggcttcacca tccctagcta catgatcagc 1140
3184、tacgccggca tggtgttctg cgaggccaag atcaacgacg agagctatca gagcatcatg 1200
3185、tacatcgtgg tcgtggtggg cgacaaaact catacctgcc caccttgtcc agcaccagag 1260
3186、ctgctcggag gaccatccgt gttcctgttt ccacccaagc ccaaagatac tctgatgatt 1320
3187、tcacgcacac ccgaagtcac ttgcgtggtc gtggacgtgt cccacgagga ccccgaagtc 1380
3188、aagtttaact ggtacgtgga cggcgtcgag gtgcataatg ctaagacaaa accccgagag 1440
3189、gaacagtaca actctaccta tagggtcgtg agtgtcctga cagtgctcca ccaggattgg 1500
3190、ctgaacggaa aggagtataa gtgcaaagtg tctaataagg cactgcctgc cccaatcgag 1560
3191、aaaacaatta gtaaggccaa agggcagccc agagaacctc aggtgtacac tctgcctcca 1620
3192、tctcgggacg agctcactaa gaaccaggtc agtctgacct gtctcgtgaa agggttctat 1680
3193、cctagtgata tcgctgtgga gtgggaatca aatggtcagc cagagaacaa ttacaagacc 1740
3194、acaccccctg tcctggacag cgatggctcc ttctttctgt attccaagct caccgtggac 1800
3195、aaatctcgat ggcagcaggg aaacgtcttt agttgttcag tgatgcacga agccctccat 1860
3196、aaccactaca ctcagaaaag cctcagcctc agccctggga aatga 1905
3197、<210> 68
3198、<211> 1887
3199、<212> dna
3200、<213> 人工序列
3201、<220>
3202、<223> 示例性多肽6的核酸(如exg102-25中)
3203、<400> 68
3204、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3205、actggttctt cttctgggtc cgatactggg cgccccttcg tggagatgta ctccgagatc 120
3206、cctgaaatca ttcacatgac tgagggtcgg gaactggtca tcccatgccg cgtgacctct 180
3207、cccaacatta ctgtgaccct gaagaaattc cctctggaca ccctcatccc agatgggaag 240
3208、aggatcattt gggactcaag aaagggtttt atcatcagca acgctacata caaggagatt 300
3209、ggcctgctca cctgcgaagc aacagtgaac ggacacctgt acaagactaa ttatctcacc 360
3210、catagacaga caaacactat cattgatgtg gtcctgtcac caagccacgg catcgagctc 420
3211、agcgtcggtg aaaagctggt gctcaattgt acagcccgga ctgagctgaa cgtgggcatt 480
3212、gacttcaatt gggaataccc cagctccaag caccagcata agaaactggt gaaccgcgat 540
3213、ctcaaaaccc agtccggatc tgagatgaag aaatttctga gcaccctcac aatcgacggc 600
3214、gtgacacgat ccgatcaggg actgtatact tgcgccgctt ctagtggcct gatgaccaag 660
3215、aaaaatagca cattcgtcag ggtgcacgaa aagggcggcg gcggaggcag cgtgtacgtg 720
3216、caagactaca gaagcccctt catcgctagc gtgagcgatc agcacggcgt ggtgtacatc 780
3217、accgagaaca agaacaagac cgtggtgatc ccctgcctgg gcagcatcag caacctgaac 840
3218、gtgagcctgt gcgctagata ccccgagaag agattcgtgc ccgacggcaa cagaatcagc 900
3219、tgggacagca agaagggctt caccatccct agctacatga tcagctacgc cggcatggtg 960
3220、ttctgcgagg ccaagatcaa cgacgagagc tatcagagca tcatgtacat cgtggtcgtg 1020
3221、gtgggcgaca aaactcatac ctgcccacct tgtccagcac cagagctgct cggaggacca 1080
3222、tccgtgttcc tgtttccacc caagcccaaa gatactctga tgatttcacg cacacccgaa 1140
3223、gtcacttgcg tggtcgtgga cgtgtcccac gaggaccccg aagtcaagtt taactggtac 1200
3224、gtggacggcg tcgaggtgca taatgctaag acaaaacccc gagaggaaca gtacaactct 1260
3225、acctataggg tcgtgagtgt cctgacagtg ctccaccagg attggctgaa cggaaaggag 1320
3226、tataagtgca aagtgtctaa taaggcactg cctgccccaa tcgagaaaac aattagtaag 1380
3227、gccaaagggc agcccagaga acctcaggtg tacactctgc ctccatctcg ggacgagctc 1440
3228、actaagaacc aggtcagtct gacctgtctc gtgaaagggt tctatcctag tgatatcgct 1500
3229、gtggagtggg aatcaaatgg tcagccagag aacaattaca agaccacacc ccctgtcctg 1560
3230、gacagcgatg gctccttctt tctgtattcc aagctcaccg tggacaaatc tcgatggcag 1620
3231、cagggaaacg tctttagttg ttcagtgatg cacgaagccc tccataacca ctacactcag 1680
3232、aaaagcctca gcctcagccc tgggaaaggc ggcggcggag gcgcccagca agaagagtgc 1740
3233、gagtgggatc cctggacctg cgagcacatg ggatccggca gcgccaccgg aggatccgga 1800
3234、agcaccgcct ccagcggctc cggcagcgcc acccaccagg aggagtgtga gtgggacccc 1860
3235、tggacctgcg agcacatgct ggagtga 1887
3236、<210> 69
3237、<211> 1920
3238、<212> dna
3239、<213> 人工序列
3240、<220>
3241、<223> 示例性多肽7的核酸(如exg102-26中)
3242、<400> 69
3243、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3244、actggttctt cttctgggtc cgatactggg cgccccttcg tggagatgta ctccgagatc 120
3245、cctgaaatca ttcacatgac tgagggtcgg gaactggtca tcccatgccg cgtgacctct 180
3246、cccaacatta ctgtgaccct gaagaaattc cctctggaca ccctcatccc agatgggaag 240
3247、aggatcattt gggactcaag aaagggtttt atcatcagca acgctacata caaggagatt 300
3248、ggcctgctca cctgcgaagc aacagtgaac ggacacctgt acaagactaa ttatctcacc 360
3249、catagacaga caaacactat cattgatgtg gtcctgtcac caagccacgg catcgagctc 420
3250、agcgtcggtg aaaagctggt gctcaattgt acagcccgga ctgagctgaa cgtgggcatt 480
3251、gacttcaatt gggaataccc cagctccaag caccagcata agaaactggt gaaccgcgat 540
3252、ctcaaaaccc agtccggatc tgagatgaag aaatttctga gcaccctcac aatcgacggc 600
3253、gtgacacgat ccgatcaggg actgtatact tgcgccgctt ctagtggcct gatgaccaag 660
3254、aaaaatagca cattcgtcag ggtgcacgaa aagggcggcg gcggaggcag cgtgtacgtg 720
3255、caagactaca gaagcccctt catcgctagc gtgagcgatc agcacggcgt ggtgtacatc 780
3256、accgagaaca agaacaagac cgtggtgatc ccctgcctgg gcagcatcag caacctgaac 840
3257、gtgagcctgt gcgctagata ccccgagaag agattcgtgc ccgacggcaa cagaatcagc 900
3258、tgggacagca agaagggctt caccatccct agctacatga tcagctacgc cggcatggtg 960
3259、ttctgcgagg ccaagatcaa cgacgagagc tatcagagca tcatgtacat cgtggtcgtg 1020
3260、gtgggcgaca aaactcatac ctgcccacct tgtccagcac cagagctgct cggaggacca 1080
3261、tccgtgttcc tgtttccacc caagcccaaa gatactctga tgatttcacg cacacccgaa 1140
3262、gtcacttgcg tggtcgtgga cgtgtcccac gaggaccccg aagtcaagtt taactggtac 1200
3263、gtggacggcg tcgaggtgca taatgctaag acaaaacccc gagaggaaca gtacaactct 1260
3264、acctataggg tcgtgagtgt cctgacagtg ctccaccagg attggctgaa cggaaaggag 1320
3265、tataagtgca aagtgtctaa taaggcactg cctgccccaa tcgagaaaac aattagtaag 1380
3266、gccaaagggc agcccagaga acctcaggtg tacactctgc ctccatctcg ggacgagctc 1440
3267、actaagaacc aggtcagtct gacctgtctc gtgaaagggt tctatcctag tgatatcgct 1500
3268、gtggagtggg aatcaaatgg tcagccagag aacaattaca agaccacacc ccctgtcctg 1560
3269、gacagcgatg gctccttctt tctgtattcc aagctcaccg tggacaaatc tcgatggcag 1620
3270、cagggaaacg tctttagttg ttcagtgatg cacgaagccc tccataacca ctacactcag 1680
3271、aaaagcctca gcctcagccc tgggaaaggg ggcgggggcg gcgctcaagg cagcgggagc 1740
3272、gctaccggcg gctccgggag cacagctagc agcggcagcg gctccgctac ccacaagttc 1800
3273、aaccccctgg acgagctgga ggagaccctc tacgagcagt tcaccttcca acaaggcggg 1860
3274、ggcgggggcc aagaggagtg cgagtgggac ccctggacct gcgagcacat gctggagtga 1920
3275、<210> 70
3276、<211> 2196
3277、<212> dna
3278、<213> 人工序列
3279、<220>
3280、<223> 示例性多肽8的核酸(如exg102-27中)
3281、<400> 70
3282、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3283、actggttctt cttctggggg cggcggcgga ggcgcccagc aagaagagtg cgagtgggat 120
3284、ccctggacct gcgagcacat gggatccggc agcgccaccg gaggatccgg aagcaccgcc 180
3285、tccagcggct ccggcagcgc cacccaccag gaggagtgtg agtgggaccc ctggacctgc 240
3286、gaacacatgc tggagggcgg cggcggaggc agctccgata ctgggcgccc cttcgtggag 300
3287、atgtactccg agatccctga aatcattcac atgactgagg gtcgggaact ggtcatccca 360
3288、tgccgcgtga cctctcccaa cattactgtg accctgaaga aattccctct ggacaccctc 420
3289、atcccagatg ggaagaggat catttgggac tcaagaaagg gttttatcat cagcaacgct 480
3290、acatacaagg agattggcct gctcacctgc gaagcaacag tgaacggaca cctgtacaag 540
3291、actaattatc tcacccatag acagacaaac actatcattg atgtggtcct gtcaccaagc 600
3292、cacggcatcg agctcagcgt cggtgaaaag ctggtgctca attgtacagc ccggactgag 660
3293、ctgaacgtgg gcattgactt caattgggaa taccccagct ccaagcacca gcataagaaa 720
3294、ctggtgaacc gcgatctcaa aacccagtcc ggatctgaga tgaagaaatt tctgagcacc 780
3295、ctcacaatcg acggcgtgac acgatccgat cagggactgt atacttgcgc cgcttctagt 840
3296、ggcctgatga ccaagaaaaa tagcacattc gtcagggtgc acgaaaaggg cggcggcgga 900
3297、ggcagctact ccatgacccc cccgaccctg aacatcaccg aggagagcca cgtgatcgac 960
3298、accggcgaca gcctgagcat cagttgccgg ggccaacacc ccctggaatg ggcatggcct 1020
3299、ggggcacaag aggcccccgc aacgggcgac aaggacagcg aggacaccgg cgtggtgaga 1080
3300、gactgcgagg gcaccgacgc tagaccctac tgcaaggtgc tgctgctgca cgaggtgcac 1140
3301、gcccaagaca ccggtagcta cgtgtgctac tataagtaca tcaaggctag aatcgagggc 1200
3302、accaccgccg ctagcagcta cgtgtttgtg agagacttcg agcagccctt catcaacaag 1260
3303、cccgacaccc tgctggtgaa cagaaaggac gccatgtggg tgccctgcct ggtgagcatc 1320
3304、cccggcctga acgtgaccct gagatctcag agcagcgtgc tgtggcccga cggccaagag 1380
3305、gtggtgtggg acgacagaag aggcatgctg gtgagcaccc ccctgctgca cgacgccctg 1440
3306、tacctgcagt gcgagaccac ctggggcgac caagacttcc tgagcaaccc cttcctggtg 1500
3307、cacatcacag gcgacaaaac tcatacctgc ccaccttgtc cagcaccaga gctgctcgga 1560
3308、ggaccatccg tgttcctgtt tccacccaag cccaaagata ctctgatgat ttcacgcaca 1620
3309、cccgaagtca cttgcgtggt cgtggacgtg tcccacgagg accccgaagt caagtttaac 1680
3310、tggtacgtgg acggcgtcga ggtgcataat gctaagacaa aaccccgaga ggaacagtac 1740
3311、aactctacct atagggtcgt gagtgtcctg acagtgctcc accaggattg gctgaacgga 1800
3312、aaggagtata agtgcaaagt gtctaataag gcactgcctg ccccaatcga gaaaacaatt 1860
3313、agtaaggcca aagggcagcc cagagaacct caggtgtaca ctctgcctcc atctcgggac 1920
3314、gagctcacta agaaccaggt cagtctgacc tgtctcgtga aagggttcta tcctagtgat 1980
3315、atcgctgtgg agtgggaatc aaatggtcag ccagagaaca attacaagac cacaccccct 2040
3316、gtcctggaca gcgatggctc cttctttctg tattccaagc tcaccgtgga caaatctcga 2100
3317、tggcagcagg gaaacgtctt tagttgttca gtgatgcacg aagccctcca taaccactac 2160
3318、actcagaaaa gcctcagcct cagccctggg aaatga 2196
3319、<210> 71
3320、<211> 2178
3321、<212> dna
3322、<213> 人工序列
3323、<220>
3324、<223> 示例性多肽9的核酸(如exg102-28中)
3325、<400> 71
3326、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3327、actggttctt cttctgggtc cgatactggg cgccccttcg tggagatgta ctccgagatc 120
3328、cctgaaatca ttcacatgac tgagggtcgg gaactggtca tcccatgccg cgtgacctct 180
3329、cccaacatta ctgtgaccct gaagaaattc cctctggaca ccctcatccc agatgggaag 240
3330、aggatcattt gggactcaag aaagggtttt atcatcagca acgctacata caaggagatt 300
3331、ggcctgctca cctgcgaagc aacagtgaac ggacacctgt acaagactaa ttatctcacc 360
3332、catagacaga caaacactat cattgatgtg gtcctgtcac caagccacgg catcgagctc 420
3333、agcgtcggtg aaaagctggt gctcaattgt acagcccgga ctgagctgaa cgtgggcatt 480
3334、gacttcaatt gggaataccc cagctccaag caccagcata agaaactggt gaaccgcgat 540
3335、ctcaaaaccc agtccggatc tgagatgaag aaatttctga gcaccctcac aatcgacggc 600
3336、gtgacacgat ccgatcaggg actgtatact tgcgccgctt ctagtggcct gatgaccaag 660
3337、aaaaatagca cattcgtcag ggtgcacgaa aagggcggcg gcggaggcag ctactccatg 720
3338、acccccccga ccctgaacat caccgaggag agccacgtga tcgacaccgg cgacagcctg 780
3339、agcatcagtt gccggggcca acaccccctg gaatgggcat ggcctggggc acaagaggcc 840
3340、cccgcaacgg gcgacaagga cagcgaggac accggcgtgg tgagagactg cgagggcacc 900
3341、gacgctagac cctactgcaa ggtgctgctg ctgcacgagg tgcacgccca agacaccggt 960
3342、agctacgtgt gctactataa gtacatcaag gctagaatcg agggcaccac cgccgctagc 1020
3343、agctacgtgt ttgtgagaga cttcgagcag cccttcatca acaagcccga caccctgctg 1080
3344、gtgaacagaa aggacgccat gtgggtgccc tgcctggtga gcatccccgg cctgaacgtg 1140
3345、accctgagat ctcagagcag cgtgctgtgg cccgacggcc aagaggtggt gtgggacgac 1200
3346、agaagaggca tgctggtgag cacccccctg ctgcacgacg ccctgtacct gcagtgcgag 1260
3347、accacctggg gcgaccaaga cttcctgagc aaccccttcc tggtgcacat caccggcgac 1320
3348、aaaactcata cctgcccacc ttgtccagca ccagagctgc tcggaggacc atccgtgttc 1380
3349、ctgtttccac ccaagcccaa agatactctg atgatttcac gcacacccga agtcacttgc 1440
3350、gtggtcgtgg acgtgtccca cgaggacccc gaagtcaagt ttaactggta cgtggacggc 1500
3351、gtcgaggtgc ataatgctaa gacaaaaccc cgagaggaac agtacaactc tacctatagg 1560
3352、gtcgtgagtg tcctgacagt gctccaccag gattggctga acggaaagga gtataagtgc 1620
3353、aaagtgtcta ataaggcact gcctgcccca atcgagaaaa caattagtaa ggccaaaggg 1680
3354、cagcccagag aacctcaggt gtacactctg cctccatctc gggacgagct cactaagaac 1740
3355、caggtcagtc tgacctgtct cgtgaaaggg ttctatccta gtgatatcgc tgtggagtgg 1800
3356、gaatcaaatg gtcagccaga gaacaattac aagaccacac cccctgtcct ggacagcgat 1860
3357、ggctccttct ttctgtattc caagctcacc gtggacaaat ctcgatggca gcagggaaac 1920
3358、gtctttagtt gttcagtgat gcacgaagcc ctccataacc actacactca gaaaagcctc 1980
3359、agcctcagcc ctgggaaagg cggcggcgga ggcgcccagc aagaagagtg cgagtgggat 2040
3360、ccctggacct gcgagcacat gggatccggc agcgccaccg gaggatccgg aagcaccgcc 2100
3361、tccagcggct ccggcagcgc cacccaccag gaggagtgtg agtgggaccc ctggacctgc 2160
3362、gaacacatgc tggagtga 2178
3363、<210> 72
3364、<211> 2211
3365、<212> dna
3366、<213> 人工序列
3367、<220>
3368、<223> 示例性多肽10的核酸(如exg102-29中)
3369、<400> 72
3370、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3371、actggttctt cttctgggtc cgatactggg cgccccttcg tggagatgta ctccgagatc 120
3372、cctgaaatca ttcacatgac tgagggtcgg gaactggtca tcccatgccg cgtgacctct 180
3373、cccaacatta ctgtgaccct gaagaaattc cctctggaca ccctcatccc agatgggaag 240
3374、aggatcattt gggactcaag aaagggtttt atcatcagca acgctacata caaggagatt 300
3375、ggcctgctca cctgcgaagc aacagtgaac ggacacctgt acaagactaa ttatctcacc 360
3376、catagacaga caaacactat cattgatgtg gtcctgtcac caagccacgg catcgagctc 420
3377、agcgtcggtg aaaagctggt gctcaattgt acagcccgga ctgagctgaa cgtgggcatt 480
3378、gacttcaatt gggaataccc cagctccaag caccagcata agaaactggt gaaccgcgat 540
3379、ctcaaaaccc agtccggatc tgagatgaag aaatttctga gcaccctcac aatcgacggc 600
3380、gtgacacgat ccgatcaggg actgtatact tgcgccgctt ctagtggcct gatgaccaag 660
3381、aaaaatagca cattcgtcag ggtgcacgaa aagggcggcg gcggaggcag ctactccatg 720
3382、acccccccga ccctgaacat caccgaggag agccacgtga tcgacaccgg cgacagcctg 780
3383、agcatcagtt gccggggcca acaccccctg gaatgggcat ggcctggggc acaagaggcc 840
3384、cccgcaacgg gcgacaagga cagcgaggac accggcgtgg tgagagactg cgagggcacc 900
3385、gacgctagac cctactgcaa ggtgctgctg ctgcacgagg tgcacgccca agacaccggt 960
3386、agctacgtgt gctactataa gtacatcaag gctagaatcg agggcaccac cgccgctagc 1020
3387、agctacgtgt ttgtgagaga cttcgagcag cccttcatca acaagcccga caccctgctg 1080
3388、gtgaacagaa aggacgccat gtgggtgccc tgcctggtga gcatccccgg cctgaacgtg 1140
3389、accctgagat ctcagagcag cgtgctgtgg cccgacggcc aagaggtggt gtgggacgac 1200
3390、agaagaggca tgctggtgag cacccccctg ctgcacgacg ccctgtacct gcagtgcgag 1260
3391、accacctggg gcgaccaaga cttcctgagc aaccccttcc tggtgcacat caccggcgac 1320
3392、aaaactcata cctgcccacc ttgtccagca ccagagctgc tcggaggacc atccgtgttc 1380
3393、ctgtttccac ccaagcccaa agatactctg atgatttcac gcacacccga agtcacttgc 1440
3394、gtggtcgtgg acgtgtccca cgaggacccc gaagtcaagt ttaactggta cgtggacggc 1500
3395、gtcgaggtgc ataatgctaa gacaaaaccc cgagaggaac agtacaactc tacctatagg 1560
3396、gtcgtgagtg tcctgacagt gctccaccag gattggctga acggaaagga gtataagtgc 1620
3397、aaagtgtcta ataaggcact gcctgcccca atcgagaaaa caattagtaa ggccaaaggg 1680
3398、cagcccagag aacctcaggt gtacactctg cctccatctc gggacgagct cactaagaac 1740
3399、caggtcagtc tgacctgtct cgtgaaaggg ttctatccta gtgatatcgc tgtggagtgg 1800
3400、gaatcaaatg gtcagccaga gaacaattac aagaccacac cccctgtcct ggacagcgat 1860
3401、ggctccttct ttctgtattc caagctcacc gtggacaaat ctcgatggca gcagggaaac 1920
3402、gtctttagtt gttcagtgat gcacgaagcc ctccataacc actacactca gaaaagcctc 1980
3403、agcctcagcc ctgggaaagg gggcgggggc ggcgctcaag gcagcgggag cgctaccggc 2040
3404、ggctccggga gcacagctag cagcggcagc ggctccgcta cccacaagtt caaccccctg 2100
3405、gacgagctgg aggagaccct ctacgagcag ttcaccttcc aacaaggcgg gggcgggggc 2160
3406、caagaggagt gcgagtggga cccctggacc tgcgagcaca tgctggagtg a 2211
3407、<210> 73
3408、<211> 1605
3409、<212> dna
3410、<213> 人工序列
3411、<220>
3412、<223> 示例性多肽11的核酸(如exg102-30中)
3413、<400> 73
3414、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3415、actggttctt cttctggggg gggcgggggc ggcgctcaag gcagcgggag cgctaccggc 120
3416、ggctccggga gcacagctag cagcggcagc ggctccgcta cccacaagtt caaccccctg 180
3417、gacgagctgg aggagaccct ctacgagcag ttcaccttcc aacaaggcgg gggcgggggc 240
3418、caagaggagt gcgagtggga cccctggacc tgcgagcaca tgctggaggg cggcggcgga 300
3419、ggcagctccg atactgggcg ccccttcgtg gagatgtact ccgagatccc tgaaatcatt 360
3420、cacatgactg agggtcggga actggtcatc ccatgccgcg tgacctctcc caacattact 420
3421、gtgaccctga agaaattccc tctggacacc ctcatcccag atgggaagag gatcatttgg 480
3422、gactcaagaa agggttttat catcagcaac gctacataca aggagattgg cctgctcacc 540
3423、tgcgaagcaa cagtgaacgg acacctgtac aagactaatt atctcaccca tagacagaca 600
3424、aacactatca ttgatgtggt cctgtcacca agccacggca tcgagctcag cgtcggtgaa 660
3425、aagctggtgc tcaattgtac agcccggact gagctgaacg tgggcattga cttcaattgg 720
3426、gaatacccca gctccaagca ccagcataag aaactggtga accgcgatct caaaacccag 780
3427、tccggatctg agatgaagaa atttctgagc accctcacaa tcgacggcgt gacacgatcc 840
3428、gatcagggac tgtatacttg cgccgcttct agtggcctga tgaccaagaa aaatagcaca 900
3429、ttcgtcaggg tgcacgaaaa ggacaaaact catacctgcc caccttgtcc agcaccagag 960
3430、ctgctcggag gaccatccgt gttcctgttt ccacccaagc ccaaagatac tctgatgatt 1020
3431、tcacgcacac ccgaagtcac ttgcgtggtc gtggacgtgt cccacgagga ccccgaagtc 1080
3432、aagtttaact ggtacgtgga cggcgtcgag gtgcataatg ctaagacaaa accccgagag 1140
3433、gaacagtaca actctaccta tagggtcgtg agtgtcctga cagtgctcca ccaggattgg 1200
3434、ctgaacggaa aggagtataa gtgcaaagtg tctaataagg cactgcctgc cccaatcgag 1260
3435、aaaacaatta gtaaggccaa agggcagccc agagaacctc aggtgtacac tctgcctcca 1320
3436、tctcgggacg agctcactaa gaaccaggtc agtctgacct gtctcgtgaa agggttctat 1380
3437、cctagtgata tcgctgtgga gtgggaatca aatggtcagc cagagaacaa ttacaagacc 1440
3438、acaccccctg tcctggacag cgatggctcc ttctttctgt attccaagct caccgtggac 1500
3439、aaatctcgat ggcagcaggg aaacgtcttt agttgttcag tgatgcacga agccctccat 1560
3440、aaccactaca ctcagaaaag cctcagcctc agccctggga aatga 1605
3441、<210> 74
3442、<211> 2229
3443、<212> dna
3444、<213> 人工序列
3445、<220>
3446、<223> 示例性多肽12的核酸(如exg102-31中)
3447、<400> 74
3448、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3449、actggttctt cttctggggg gggcgggggc ggcgctcaag gcagcgggag cgctaccggc 120
3450、ggctccggga gcacagctag cagcggcagc ggctccgcta cccacaagtt caaccccctg 180
3451、gacgagctgg aggagaccct ctacgagcag ttcaccttcc aacaaggcgg gggcgggggc 240
3452、caagaggagt gcgagtggga cccctggacc tgcgagcaca tgctggaggg cggcggcgga 300
3453、ggcagctccg atactgggcg ccccttcgtg gagatgtact ccgagatccc tgaaatcatt 360
3454、cacatgactg agggtcggga actggtcatc ccatgccgcg tgacctctcc caacattact 420
3455、gtgaccctga agaaattccc tctggacacc ctcatcccag atgggaagag gatcatttgg 480
3456、gactcaagaa agggttttat catcagcaac gctacataca aggagattgg cctgctcacc 540
3457、tgcgaagcaa cagtgaacgg acacctgtac aagactaatt atctcaccca tagacagaca 600
3458、aacactatca ttgatgtggt cctgtcacca agccacggca tcgagctcag cgtcggtgaa 660
3459、aagctggtgc tcaattgtac agcccggact gagctgaacg tgggcattga cttcaattgg 720
3460、gaatacccca gctccaagca ccagcataag aaactggtga accgcgatct caaaacccag 780
3461、tccggatctg agatgaagaa atttctgagc accctcacaa tcgacggcgt gacacgatcc 840
3462、gatcagggac tgtatacttg cgccgcttct agtggcctga tgaccaagaa aaatagcaca 900
3463、ttcgtcaggg tgcacgaaaa gggcggcggc ggaggcagct actccatgac ccccccgacc 960
3464、ctgaacatca ccgaggagag ccacgtgatc gacaccggcg acagcctgag catcagttgc 1020
3465、cggggccaac accccctgga atgggcatgg cctggggcac aagaggcccc cgcaacgggc 1080
3466、gacaaggaca gcgaggacac cggcgtggtg agagactgcg agggcaccga cgctagaccc 1140
3467、tactgcaagg tgctgctgct gcacgaggtg cacgccaacg acaccggtag ctacgtgtgc 1200
3468、tactataagt acatcaaggc tagaatcgag ggcaccaccg ccgctagcag ctacgtgttt 1260
3469、gtgagagact tcgagcagcc cttcatcaac aagcccgaca ccctgctggt gaacagaaag 1320
3470、gacgccatgt gggtgccctg cctggtgagc atccccggcc tgaacgtgac cctgagatct 1380
3471、cagagcagcg tgctgtggcc cgacggccaa gaggtggtgt gggacgacag aagaggcatg 1440
3472、ctggtgagca cccccctgct gcacgacgcc ctgtacctgc agtgcgagac cacctggggc 1500
3473、gaccaagact tcctgagcaa ccccttcctg gtgcacatca caggcgacaa aactcatacc 1560
3474、tgcccacctt gtccagcacc agagctgctc ggaggaccat ccgtgttcct gtttccaccc 1620
3475、aagcccaaag atactctgat gatttcacgc acacccgaag tcacttgcgt ggtcgtggac 1680
3476、gtgtcccacg aggaccccga agtcaagttt aactggtacg tggacggcgt cgaggtgcat 1740
3477、aatgctaaga caaaaccccg agaggaacag tacaactcta cctatagggt cgtgagtgtc 1800
3478、ctgacagtgc tccaccagga ttggctgaac ggaaaggagt ataagtgcaa agtgtctaat 1860
3479、aaggcactgc ctgccccaat cgagaaaaca attagtaagg ccaaagggca gcccagagaa 1920
3480、cctcaggtgt acactctgcc tccatctcgg gacgagctca ctaagaacca ggtcagtctg 1980
3481、acctgtctcg tgaaagggtt ctatcctagt gatatcgctg tggagtggga atcaaatggt 2040
3482、cagccagaga acaattacaa gaccacaccc cctgtcctgg acagcgatgg ctccttcttt 2100
3483、ctgtattcca agctcaccgt ggacaaatct cgatggcagc agggaaacgt ctttagttgt 2160
3484、tcagtgatgc acgaagccct ccataaccac tacactcaga aaagcctcag cctcagccct 2220
3485、gggaaatga 2229
3486、<210> 75
3487、<211> 2211
3488、<212> dna
3489、<213> 人工序列
3490、<220>
3491、<223> 示例性多肽13的核酸(如exg102-32中)
3492、<400> 75
3493、atggtgtctt attgggatac tggcgtgctg ctctgtgccc tcctgagttg cctgctcctg 60
3494、actggttctt cttctgggtc cgatactggg cgccccttcg tggagatgta ctccgagatc 120
3495、cctgaaatca ttcacatgac tgagggtcgg gaactggtca tcccatgccg cgtgacctct 180
3496、cccaacatta ctgtgaccct gaagaaattc cctctggaca ccctcatccc agatgggaag 240
3497、aggatcattt gggactcaag aaagggtttt atcatcagca acgctacata caaggagatt 300
3498、ggcctgctca cctgcgaagc aacagtgaac ggacacctgt acaagactaa ttatctcacc 360
3499、catagacaga caaacactat cattgatgtg gtcctgtcac caagccacgg catcgagctc 420
3500、agcgtcggtg aaaagctggt gctcaattgt acagcccgga ctgagctgaa cgtgggcatt 480
3501、gacttcaatt gggaataccc cagctccaag caccagcata agaaactggt gaaccgcgat 540
3502、ctcaaaaccc agtccggatc tgagatgaag aaatttctga gcaccctcac aatcgacggc 600
3503、gtgacacgat ccgatcaggg actgtatact tgcgccgctt ctagtggcct gatgaccaag 660
3504、aaaaatagca cattcgtcag ggtgcacgaa aagggcggcg gcggaggcag ctactccatg 720
3505、acccccccga ccctgaacat caccgaggag agccacgtga tcgacaccgg cgacagcctg 780
3506、agcatcagtt gccggggcca acaccccctg gaatgggcat ggcctggggc acaagaggcc 840
3507、cccgcaacgg gcgacaagga cagcgaggac accggcgtgg tgagagactg cgagggcacc 900
3508、gacgctagac cctactgcaa ggtgctgctg ctgcacgagg tgcacgccaa cgacaccggt 960
3509、agctacgtgt gctactataa gtacatcaag gctagaatcg agggcaccac cgccgctagc 1020
3510、agctacgtgt ttgtgagaga cttcgagcag cccttcatca acaagcccga caccctgctg 1080
3511、gtgaacagaa aggacgccat gtgggtgccc tgcctggtga gcatccccgg cctgaacgtg 1140
3512、accctgagat ctcagagcag cgtgctgtgg cccgacggcc aagaggtggt gtgggacgac 1200
3513、agaagaggca tgctggtgag cacccccctg ctgcacgacg ccctgtacct gcagtgcgag 1260
3514、accacctggg gcgaccaaga cttcctgagc aaccccttcc tggtgcacat cacaggcgac 1320
3515、aaaactcata cctgcccacc ttgtccagca ccagagctgc tcggaggacc atccgtgttc 1380
3516、ctgtttccac ccaagcccaa agatactctg atgatttcac gcacacccga agtcacttgc 1440
3517、gtggtcgtgg acgtgtccca cgaggacccc gaagtcaagt ttaactggta cgtggacggc 1500
3518、gtcgaggtgc ataatgctaa gacaaaaccc cgagaggaac agtacaactc tacctatagg 1560
3519、gtcgtgagtg tcctgacagt gctccaccag gattggctga acggaaagga gtataagtgc 1620
3520、aaagtgtcta ataaggcact gcctgcccca atcgagaaaa caattagtaa ggccaaaggg 1680
3521、cagcccagag aacctcaggt gtacactctg cctccatctc gggacgagct cactaagaac 1740
3522、caggtcagtc tgacctgtct cgtgaaaggg ttctatccta gtgatatcgc tgtggagtgg 1800
3523、gaatcaaatg gtcagccaga gaacaattac aagaccacac cccctgtcct ggacagcgat 1860
3524、ggctccttct ttctgtattc caagctcacc gtggacaaat ctcgatggca gcagggaaac 1920
3525、gtctttagtt gttcagtgat gcacgaagcc ctccataacc actacactca gaaaagcctc 1980
3526、agcctcagcc ctgggaaagg gggcgggggc ggcgctcaag gcagcgggag cgctaccggc 2040
3527、ggctccggga gcacagctag cagcggcagc ggctccgcta cccacaagtt caaccccctg 2100
3528、gacgagctgg aggagaccct ctacgagcag ttcaccttcc aacaaggcgg gggcgggggc 2160
3529、caagaggagt gcgagtggga cccctggacc tgcgagcaca tgctggagtg a 2211
技术实现思路