1)Multidrug resistance gene 1多药耐药基因1
1.Effects of iron-deprivation on the activation of NFκB and the expression of multidrug resistance gene 1 of K562 cells induced by daunorubicin;铁剥夺对柔红霉素诱导K562细胞多药耐药基因1表达及NFκB活化的影响
2.Many factors affect the platinum-based chemotherapeutic effect including multidrug resistance gene 1(MDR1) and Excision Repair Cross-Complementation group 1.导致铂类耐药的原因很多,其中包含多药耐药基因1(MDR1)和切除修复交叉互补基1(ERCC1),其多态性对铂类化疗疗效产生重要影响,并有可能成为预测化疗疗效的因子来指导临床个体化化疗。
3.Objective To study the relativity of multidrug resistance gene 1(MDR1) gene expression and acquired tolerance to arsenic in human hepatocyte cell line(L-02).目的观察多药耐药基因1(MDR1)在耐砷的人肝细胞(L-02)中的表达情况,探讨其与L-02耐砷性的关系。
英文短句/例句
1.Overexpression of MDR1 is associated with acquired tolerance to arsenic in L-02 cells多药耐药基因1与人肝细胞耐砷性关系
2.Association between the C1236T polymorphism in multi-drug resistance gene 1 and response to antiepileptic drug treatment in epileptic patients多药耐药基因1 C1236T多态性与癫痫患者对药物反应性的相关性
3.Establishment of genotyping method for multi-drug resistance gene 1 polymorphisms with DNA microarray基因芯片检测肿瘤病人多药耐药基因1多态性方法的建立
4.Construction of Multidrug Resistance Gene-1 shRNA Vector and Research of Its Function for Human Resistance Leukemia Cells人耐药白血病细胞多药耐药基因-1小干扰RNA的构建及功能研究
5.Expression of Heat Shock Factor-1 and Multidrug Resistance Gene-1 in Renal Cell Carcinoma and Its Significance;热休克因子-1和多药耐药基因-1在肾癌中的表达及其意义
6.Study on multidrug resistance to tumor of cytokine-induced killer(CIK) cells after transfected with the multidrug resistance(mdr1) cDNA多药耐药基因转染的CIK细胞耐药性研究
7.Multi-drug Resistant Genes of Pseudomonas aeruginosa Clinical Strains多药耐药铜绿假单胞菌相关耐药基因研究
8.Multidrug Resistance-Associated Protein Gene Mediated Drug Resistance in Acute Leukemias;急性白血病多药耐药相关蛋白基因介导的多药耐药研究
9.THE EXPRESSION OF MDR1 GENE IN LEUKEMIC CELIS AMD ITS CLINICAL SIGNIFICANCE多药耐药基因在白血病细胞中的表达
10.Study of Mutidrug Resistance Gene Expression in Breast Cancer;乳腺癌多药耐药基因检测与临床应用
11.The Verification of the Differentiated Gene Expression of Multi-drug Resistance in Ovarian Cancer;卵巢癌多药耐药差异表达基因的验证
12.Expression and Reversal of Multi-drug Resistance Gene in Ovarian Cancer Cell卵巢癌多药耐药基因的表达及其逆转
13.Study on the Resistance Genes and Resistance Transmission Mechanism in Multidrug-resistant Enterococcus;多重耐药肠球菌耐药基因筛选及传播机制研究
14.Genotyping and Drug Resistance of Pseudomonas Aeruginosa in Respiratory Intensive UnitRICU多重耐药铜绿假单胞菌耐药基因特征研究
15.The research of multidrug resistant gene in salmonella enterica paratyphi A多重耐药甲型副伤寒沙门菌耐药基因的研究
16.Genotypic drug resistance among recently HIV-1 infected bersons in Henan河南省HIV-1新近感染者耐药基因研究
17.Association of a polymorphism in MDR1 C3435T with response to antiepileptic drugs treatment in intractable epilepsy难治性癫痫的耐药性与多药耐药基因MDR1C3435T多态性的相关研究
18.Relationship between multi-drug resistance gene MDR1 and NF-kappa B in human drug-resistance erythroleukemia cells白血病耐药细胞中多药耐药基因MDR1与核转录因子κB的关系
相关短句/例句
MDR1多药耐药基因1
1.CYP3A5 and MDR1 gene polymorphisms is associated with pharmacokinetic variation of tacrolimus in renal transplant patients;细胞色素P450 3A5和多药耐药基因1基因多态性在肾移植患者他克莫司血药浓度监测中的应用
2.Objective To investigate the therapeutic efficacy and the possible action mechanisms of the recombinant adenovirus vector carrying antisense multidrug resistance gene 1(mdr1)targeting the reverse of α-fetoprotein(AFP+)positive MDR of HepG2R cells.目的探讨携带多药耐药基因1(multidrug resistance gene1,mdr1)反义RNA重组腺病毒载体靶向逆转甲胎蛋白阳性(AFP+)的肝癌多药耐药细胞HepG2R的疗效及作用机制。
3.Results The influences of independent variables on dependent variables in order of size were MDR1 3435(1)>MDR1 1236(1)>CYP3A5(2)>LDL>DBIL>Age>TC>HDL>L.结果9个自变量对因变量的影响从大到小依次为多药耐药基因1(MDR1)3435(1)、MDR11236(1)、细胞色素酶P450-3A5(CYP3A5)(2)、低密度脂蛋白胆固醇(LDL)、直接胆红素(DBIL)、年龄、总胆固醇(CHOL)、高密度脂蛋白胆固醇(HDL)、淋巴细胞(L);对方程内各自变量单独检验,CYP3A5(2)、MDR1 3435(1)、MDR1 1236(1)、DBIL、年龄、LDL、HDL对因变量有显著影响。
3)multidrug resistance 1 gene多药耐药基因1
1.Objective To explore the relationship between multidrug resistance 1 gene(mdr1) expression of the gastric cancer and its biological behavior.目的了解胃癌多药耐药基因1(mdr1)的表达及其与生物学行为的关系。
2.Objective To investigate whether the polymorphism of multidrug resistance 1 gene( MDR1) in the donors and liver transplantation recipients was correlated with interindividual variation in tacrolimus dose requirement and concentration-to-dose ratio.目的探讨普乐可复(Tacrolimus,FK506)服用剂量和血药浓度的个体差异与供受体多药耐药基因1(multidrug resistancegene1,MDR1)多态性的关系。
4)Multi-drug resistance gene 1多药耐药基因1
1.Research from home and aboard indicated that CNI\'s differences between individuals had close relationships with cytochrome P3A4 (CYP3A4), cytochrome P3A5 (CYP3A5) and Multi-drug resistance gene 1 (MDR1), the dosage of CNI for the same concentration decreased as follows: mutant homozygote, heterozygote and wild-type homozygote.国内外学者做了大量研究,认为与细胞色素酶P450-3A4(CYP3A4)、细胞色素酶P450-3A5(CYP3A5)和多药耐药基因1(MDR1)基因多态性关系密切,CNI所需剂量突变型纯合子＜杂合子＜野生型纯合子,其中MDR1通过编码药物转运体P-糖蛋白(P-gp)发挥作用,而P-gp又与细胞色素酶P450-3A(CYP3A)具有协同和相互调节作用。
5)mdr1多药耐药1基因
1.The clinical studies of expressions of Fas, P-gp and mdr1 and their correlations in acute leukemia and MDR;Fas,P-糖蛋白和多药耐药1基因在急性白血病的表达及相关性的临床研究
6)mdr1多药耐药基因-1
1.Regulation of Y-box protein 1 on the induced expression of mdr1 gene in human leukemia cell line K562;Y-盒结合蛋白1对白血病K562细胞多药耐药基因-1表达的调控
延伸阅读
安眠药、镇静药安眠药、镇静药HyPnoties，Sedatives an而anyao、Zhenjingyao安眠药、镇静药Hypnotics，SedativeS蔡月刚上海医药工业研究院L概述··············……2.主要的安眠、镇静药2.1.醇类·········.··..……2.2.环状酞胺类·····……2.3.酸脉类···········……2.4.氨基甲酸醋类·”一2.5.苯二氮草类····……2.6.吩唯嗦类·······································……312.7.乙醇胺类·······································……312.8.二苯甲烷类······················，····……，··……312.9.叱咯酮类·······································……312.10.巴比妥类·······································……31参考文献················································……咒墓本参考文献··········································……33q八成J gJ广n占亡户nt了0‘2，﹄Q乙2，︺21.概述 安眠药又称催眠药，是一类对中枢神经系统产生抑制作用的药物，在应用适当剂量时，这种抑制作用能导致睡眠(见神经调节荆)。在较小剂量时可使紧张、焦虑和兴奋不安的患者安静下来，有思睡状态，但又不致入睡，这时就称为镇静药。大剂量的安眠药还可产生麻醉。实际上安眠药和镇静药并无明显的界限，而只有量的差别。有些类别的安眠药如使用特大剂量时还可引起昏迷和可能死亡。 失眠是一种不能得到良好睡眠的生理现象，表现为入睡困难、早醒、夜不成寐，即使暂时入睡，但醒后常感头晕脑胀、腰酸背痛，并无正常睡眠醒后的清新之感等等，总之，失眠患者常不能从睡眠中完全消除疲劳。失眠常与下列原因有关;如焦虑、心理障碍、精神上的打击、噪声(见噪声)和工作过度等等。长期失眠可造成中枢神经细胞功能失调，适当应用安眠药是必要的。 理想的安眠药应能使病人安然入睡，而在醒后不遗留任何不适感，并有正常工作的能力。一般患有失眠症的人，服用安眠药后即能获得类似生理性的睡眠，但多数醒后有精神萎靡不振等不良反应。如由于某些躯体疾病，如关节炎、神经痛和心绞痛等引起的失眠，则需首先进行病因性治疗口长期应用安眠药可产生依赖性和成瘾性。 目前对于睡眠发生的机理尚不清楚，但经过多年的努力，已经深入了一步。
