1)Active targeting主动靶向
1.The recent progress of antibody-mediated, receptor-mediated and other types of active targeting drugdelivery system especially to tumor region is reviewed.综述了近年来抗体介导、受体介导和其它类型的主动靶向给药系统特别是靶向肿瘤的研究进展。
2.Attachments of specific ligands, such as monoclonal antibody or peptides, make liposomes own active targeting effect to specific cells or.通过表面修饰可以改变脂质体的性质和生物学行为：在脂质体表面修饰亲水性高分子(如聚乙二醇)可以阻碍血浆成分的调理作用，减少脂质体被网状内皮系统(RES)识别和摄取，使脂质体具有长循环的特点；在脂质体表面修饰特异性的配基(如抗体，多肽)，能使脂质体具有主动靶向的特性。
3.In this study,by means of pharmaceutics,macromolecular chemistry, pharmacology and molecular biology,HCPT loaded transferrin modified PEG-niosomes(Tf-PEG-NS) were first prepared for effective drug delivery to solid tomor by the combination of passive and active targeting.本课题通过药剂学、高分子材料学、药理学、分子生物学等手段的交叉应用,以羟基喜树碱(HCPT)为模型药物,转铁蛋白(Tf)为靶向头基,首先制备载HCPT的主动靶向隐形纳米载药系统,将聚乙二醇(PEG)修饰的隐形化效果与Tf修饰的主动靶向作用相结合,有效递送药物到达肿瘤部位。
英文短句/例句
1.Studies on Active Targeting Liposomes Directed by Chimeric TNT-3 Monoclonal Antibody;chTNT-3介导的主动靶向脂质体的研究
2.Investigation of Preparation and Pharmac-Okinetics for Oxymatrine Liposome主动靶向氧化苦参碱脂质体的制备和药物动力学研究
3.Study on the Two-ligand Modified Chitosan Nanoparticles Actively Targeting to Malignant Liver Cells双配体修饰的壳聚糖纳米粒肝癌细胞主动靶向给药系统的研究
4.Investigation on the Tumor Targeting Drug Delivery System, Enabling Insulin as Multi-Drug Carrier;以胰岛素为多药载体的肿瘤主动靶向给药系统研究
5.Investigation on the Tumor Cell Active Targeting Characteristics of Mitoxantrone-Insulin Conjugate;肿瘤细胞主动靶向米托蒽醌-胰岛素偶联物的研究
6.Study on Tumor Active Targeting with Transferrin-PEG-rHuTNF-α Conjugate;主动靶向肿瘤细胞的转铁蛋白-PEG-rHuTNF-α复合物的研究
7.Research on the Targeting Drug Using Nano-SiO_2 Hollow Sphere as Carrier;以空心纳米二氧化硅为载体的主动靶向药物的研究
8.Study on tumor active targeting with Transferrin-PEG-PAMAM dendrimer-CPT conjugate主动靶向肿瘤细胞的转铁蛋白-PEG-PAMAM-CPT复合物的研究
9.The Research on Liver Targeting Delivery System of Sodium Norcantharidate Liposome Modiffied by Galactolipid半乳糖衍生物修饰去甲斑蝥酸钠脂质体的主动靶向性研究
10.The Experimental Study of Targeted Contrast Ultrasonography on Atherosclerosis of Abdominal Aorta in Rabbits靶向超声造影评价兔腹主动脉粥样硬化的实验研究
11.A Study on Cytologic Mechanisms and Targeted Intervention Involving the Graft Arteriosclerosis in Rat Allogenic Orthotopic Abdominal Aortic Transplantation;大鼠腹主动脉移植硬化的细胞学机制及其靶向干预研究
12.Targeted molecular dynamics simulation of the closing of Kv1.2 potassium channelKv1.2钾通道闭合的靶向分子动力学模拟
13.Categories include rifle,pistol,running game target,target,trap and skeet.射击比赛种类包括：步枪，手枪，移动靶，抛靶和双向飞碟。
14.The Practical Study of Target Gene Carried by Targeting Constrast Medium Which Stabilize Atherosclerotic Plaque;靶向性造影剂携靶基因稳定动脉粥样硬化斑块的实验研究
15.Importance of Co-operation in Flying Saucer Skill;从移动靶接靶技术分析飞碟双向看接配合的重要性
16.The targets vary from fixed target, running game target to flying target.靶的种类有固定靶、移动靶和飞行靶。
17.OPPULATION DYNAMIC OF TARGET PEST,NON-TARGET PESTS AND MAJOR NATURAL ENEMY IN TRANSGENIC HYBRID POPLAR 741转基因741杨对靶标和非靶标害虫及主要天敌种群动态的影响
18.Study on Biological Characterization, Pharmacokinetics and Efficacy of Anticancer Drug as Liver-target Nanoparticles;肝靶向纳米制剂的生物特性及药动、药效学研究
相关短句/例句
initiative target主动靶向
1.We discuss the preparation and pharmac-okinetrine initiative target lipsome.本文是“氧化苦参碱脂质体”课题组对已经完成的自制普通脂质体的制备和药物动力学的进一步研究,建立了主动靶向氧化苦参碱脂质体的制备方法,进行了主动靶向氧化苦参碱脂质体在家兔体内的动力学以及在小鼠体内分布情况的研究,并且与普通脂质体、普通水溶液在家兔体内的动力学数据以及在小鼠体内分布情况进行对比,以期望增加氧化苦参碱的肝组织靶向性,同时增加不同类型脂质体的研究根据肝实质细胞膜上存在能够专一性识别含有半乳糖基或乳糖基化合物的去唾液糖蛋白受体(Asialoglycoprotein receptor, ASGP-R)[5,6];自制了乳糖酰磷脂酰乙醇胺(Lac-PE),其为两亲性分子,具有糖基亲水头部和一个长链疏水基团能够插入脂质双分子层,而糖残基暴露在脂质体表面与ASGP-R特异性结合,从而制备主动靶向氧化苦参碱脂质体。
3)active liver-targeting主动肝靶向
4)Passive/active targeting被动/主动靶向性
5)Active targeting preparation主动靶向制剂
6)active liver targeting肝脏主动靶向
延伸阅读
靶向给药分子式：CAS号：性质：靶制剂选择性地与靶细胞结合产生药理效应的过程。由于不同的给药途径药靶物制剂可以进入不同的位置，而产后不同的靶向性和作用特点。如脂质体制剂，可以静脉、腹腔、肌肉、皮下或淋巴结注射，也可以支气管给药或大脑内、脊椎给药。静脉给药时，脂质体在体内优先被富含网状内皮细胞的组织（肝脾）所摄取，并迅速被单核吞噬细胞吞噬和降解。主要包括脂质体给药系统、受体靶向及磁性药物。脂质体制剂是把药物包裹在双分子脂质膜中，此种磷脂膜与生物膜类似，成为药物的载体，它与细胞膜亲和力强，使癌细胞摄取增多，提高疗效，增加耐受性。受体靶向是利用脂质体的表面有共价键与抗肿瘤细胞表面抗原的单克隆抗体结合，使脂质体在肿瘤细胞内大量集中，提高抗肿瘤细胞的选择性。磁性药物是指药物与高磁性的硫酸铁结合，在给药后，体外使用强大的磁场，使肿瘤部位处于此种强大磁场之下，药物被选择性地集中在肿瘤细胞，提高治疗指数。
