1)antisense nucleic acid technology反义核酸技术
2)antisense ribonucleotide technique反义核酸技术
1.The effects of antisense telomerase cDNA on malignant phenotype of breast cancer cells(MCF 7)were studied by antisense ribonucleotide technique.为了进一步探讨端粒酶在肿瘤发生中的作用 ,实验应用反义核酸技术研究端粒酶反义cDNA对乳腺癌细胞MCF 7恶性表型的影响 采用的方法包括 :基因重组、脂质体共转染法获得端粒酶反义重组病毒 ,病毒感染MCF 7后 ,检测细胞的生长曲线、细胞周期及集落形成能力 结果表明 ,与对照组细胞相比 ,反义病毒感染后的MCF 7细胞恶性表型明显降低 提示端粒酶RNA的反义cDNA的导入 ,可以显著抑制乳腺癌细胞恶性表
3)Antisense interference technique反义核酸阻断技术
4)As-ODN反义寡核苷酸技术
1.As-ODN Restraint Expression of MSTN Gene;利用反义寡核苷酸技术抑制MSTN基因表达的研究
英文短句/例句
1.Effects of Skp2 Gene on Growth and Proliferation of SGC-7901 Gastric Carcinama Cells by Application of Antisense Oligonucleotides Technique;应用反义寡核苷酸技术研究Skp2基因在胃癌细胞SGC-7901生长增殖中的作用
2.antisense oligodeoxynucleotide反义寡(脱氧)核苷酸
3.Combined Anti-cancer Effects of Multiple Antisense Oligodeoxynucleotides;反义寡核苷酸联合用药的抗肿瘤研究
4.Antisense Oligonucleotides:the glint of new antimicrobial agent;反义寡核苷酸——新型抗菌药物的曙光
5.Effects of ~(32)P Labeled PDGFR-β Antisense Oligonucleotide on Cultured Vascular Smooth Muscle Cell;~(32)P标记PDGFR-β反义寡核苷酸防治冠脉术后再狭窄的体外研究
6.Antiviral effects of two antisense phosphorothioate oligodeoxynucleotides against Japanese encephalitis virus strain SA 14 in cultured BHK 21 cells反义硫代寡聚核苷酸对抗日本脑炎病毒的活性
7.The Anticancer Research of Antisense Oligonucleotides Targeting Survivin;靶向存活素的反义寡核苷酸抗肿瘤研究
8.A Study of Integrin β_1 Antisense Oligodeoxynucleotides on Pancreatic Cancer Therapy;整合素β_1反义寡核苷酸治疗胰腺癌的实验研究
9.Experimental Study of the Effects of C-erbB-2-specific Oligonucleotides on C-erbB-2 Overexpressing Breast Cancer;C-erbB-2反义寡核苷酸治疗乳腺癌的实验研究
10.Screening of Antisense Oligonucleotides,SiRNA Targeting the Messenger RNA of Endothelial Vascular Factor Feceptor-2 and Study of Their Anti-Tumor Function;KDR为靶的反义寡核苷酸,siRNA筛选及活性评价
11.Study on BCL-2 Antisense Oligonucleotides Therapy for Bladder Tumor;BCL-2反义寡核苷酸治疗膀胱肿瘤的研究
12.Preclinical Research of Phosphorothioate Antisense Oligonucleotide Named "Cantide";硫代反义寡核苷酸药物癌泰得的临床前研究
13.The Effect of TGF-β_2 ASON to the Repair of Injury Rabbit Cornea;TGF-β_2反义寡核苷酸对兔角膜损伤修复的影响
14.Study on Rheumatoid Arthritis Model with Antisense Oligodeoxynucleotide;类风湿关节炎模型的反义寡核苷酸干预的研究
15.The Effection on Stomach Carcinoma Cell by Antisense Oligonucleotides Targeting the Messenger RNA Encoding Focal Adhesion Kinase and Proliferating Cell Nuclear Antigen;粘着斑激酶和PCNA反义寡核苷酸治疗胃癌的研究
16.Experimental Study on Prostate Carcinoma Treated with Vascular Endothelial Growth Factor Antisense Oligodoxynucleotide;VEGF反义寡核苷酸治疗前列腺癌的实验研究
17.The Effects of RAGE Anti-sense Oligoxydeonucleotide on the Motility of Gastric Carcinoma Cell Lines MKN-28;RAGE反义寡核苷酸对MKN-28胃癌细胞运动的影响
18.Screening of Antisense Oligodeoxynucleotides Targeted to Survivin;靶向Survivin的抗肿瘤反义寡核苷酸先导结构的筛选
相关短句/例句
antisense ribonucleotide technique反义核酸技术
1.The effects of antisense telomerase cDNA on malignant phenotype of breast cancer cells(MCF 7)were studied by antisense ribonucleotide technique.为了进一步探讨端粒酶在肿瘤发生中的作用 ,实验应用反义核酸技术研究端粒酶反义cDNA对乳腺癌细胞MCF 7恶性表型的影响 采用的方法包括 :基因重组、脂质体共转染法获得端粒酶反义重组病毒 ,病毒感染MCF 7后 ,检测细胞的生长曲线、细胞周期及集落形成能力 结果表明 ,与对照组细胞相比 ,反义病毒感染后的MCF 7细胞恶性表型明显降低 提示端粒酶RNA的反义cDNA的导入 ,可以显著抑制乳腺癌细胞恶性表
3)Antisense interference technique反义核酸阻断技术
4)As-ODN反义寡核苷酸技术
1.As-ODN Restraint Expression of MSTN Gene;利用反义寡核苷酸技术抑制MSTN基因表达的研究
5)Antisense[英][,?nti'sens][美][,?nti's?ns, ,?nta?-]反义核酸
1.Human Antisense VEGF_(121) Expression Vector Inhibits Angiogenensis Potential of Pancreatic Cancer Cell in vitro;血管内皮生长因子_(121)反义核酸抑制人胰腺癌细胞体外促血管生成能力
2.Observation in the Antisense TRP1 Transfected Melanocytes and Malignant Melanoma Cells by Microscope and Electron Microscope;TRP-1反义核酸转染黑素细胞 黑素瘤细胞的光镜及电镜观察
3.Influence on Apoptosis in the Antisense TRP-1 Transfected Melanocytes and Malignant Melanoma Cells;TRP-1编码基因反义核酸对良恶性黑素细胞凋亡的影响
6)antisense oligonucleotide反义核酸
1.Effects of intracellular and extracellular concentrations of calcium ions in odontoblast cell line MDPC-23 by antisense oligonucleotide against dentin matrix protein 1;牙本质基质蛋白1基因反义核酸对MDPC-23细胞内、外钙离子浓度的影响
2.Effect of antisense oligonucleotide against dentin matrix protein 1 on ALP ase activity and mineralization ability of odontoblast cell line MDPC-23;牙本质基质蛋白1基因反义核酸对MDPC-23细胞碱性磷酸酶活性和矿化能力的影响
3.Objective To investigate the effect of nuclear factor kappa B(NF-κB) antisense oligonucleotide (AS-ON) on cardiac muscle myosin isoenzymes (MI) and serum cytokines (TNF-α, IL-1β, Fas) expressions in rat models of chronic heart failure.目的:探讨核转录因子(nuclear factor kappa B, NF-κB)反义核酸(antisense oligonucleotide,AS-ON)对慢性心力衰竭(chronic heart failure,CHF)病程心肌肌凝蛋白同功酶(myosin isoenzyme,MI)和细胞因子肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)和Fas的影响。
延伸阅读
反义技术分子式:CAS号:性质:根据碱基互补原理,用人工合成的或生物体中自然存在的寡核苷酸片段(即反义寡核苷酸antisense oligo nucleotide,指反义DNA和反义RNA)或其化学修饰物,结合于目标基因或mRNA上的特定序列,抑制或封闭基因表达的技术。反义作用有专一性和非专一性之分。专一性反义作用主要发生在五个层次:(1)抑制DNA的转录;(2)抑制前体mRNA的拼接;(3)抑制mRNA的戴帽及poly A尾巴的连接;(4)抑制翻译的启动;(5)阻遏核糖体在mRNA上的移动。在病毒里存在非专一性反义作用,其本质是诱导病毒的RNase H非专一性降解病毒mRNA,以抑制翻译的进行。在针对转录过程的专一性反义抑制中,反义寡聚核苷酸与双链DNA的某一段特异性结合,形成三螺旋结构。无细胞提取液等体外实验表明:三股螺旋结构能抑制DNA的复制,阻断转录因子的结合,并阻断转录的启动。依据三股螺旋结构设计反义寡核苷酸有四条原则:(1)最佳长度为20~40bp;(2)结合区段富含嘌呤碱基的那条链的嘌呤含量应在65%以上,以确保三股螺旋的结构的稳定性;(3)遵循G与G、C形成GGC,T与A、T形成TAT的原则;(4)结合区段中,若富含嘌呤的那条链中嘌呤含量过高,构建的反义寡核苷最好能与该链的反向平行。针对翻译过程的反义调控包括:干扰mRNA与核糖体的结合,干扰mRNA的构型、剪切拼接、戴帽与poly A尾的连接、激活RNase H降解mRNA等。这一技术从反向遗传学的角度认识结构基因的功能和基因表达的调控,从而为分子遗传学分析、人类疾病的防治以及动植物遗传育种等提供了崭新的手段。