1)recombinant mutant human tumor necrosis factor重组改构人肿瘤坏死因子
1.Randomized-controlled study of recombinant mutant human tumor necrosis factor in advanced malignant tumor;重组改构人肿瘤坏死因子治疗恶性肿瘤的随机对照研究
2.Inhibiting effects of recombinant mutant human tumor necrosis factor and fluorouracil on BGC-823 cells;重组改构人肿瘤坏死因子联合5-氟尿嘧啶对胃癌细胞生长的抑制作用
3.OBJECTIVE To evaluate and compare the efficacy and safety of the recombinant mutant human tumor necrosis factor(rmhTNF) combined with chemotherapy and chemotherapy alone on the treatment of patients with small cell lung cancer (SCLC).目的:对比研究国产新药重组改构人肿瘤坏死因子(rmhTNF)加化学治疗和单纯化学治疗人小细胞肺癌(SCLC)的临床疗效和安全性。
英文短句/例句
1.The Development of Neovasculature Endothelial Cells Targeted Recombinant Mutant Human Tumor Necrosis Factor Alpha;新生血管内皮细胞靶向性重组改构人肿瘤坏死因子的研制
2.Factors affecting the efficacy of rmhTNF for advanced lung cancer with maglignant pleural effusion重组改构人肿瘤坏死因子治疗晚期肺癌癌性胸腔积液疗效的影响因素分析
3.The Inhibiting Mechanism of rmhTNF-α Combined with Gemcitabine On Human Lung Adenocarcinoma Cells A549重组改构人肿瘤坏死因子协同吉西他滨抑制人肺腺癌细胞A549作用机制研究
4.Inhibiting Effects of Recombinant Mutant Human Tumor Necrosis Factor(rmhTNF) Combined with Cisplatin (DDP) on Lewis Lung Carcinoma and Its Mechanisms;重组改构人肿瘤坏死因子协同顺铂对小鼠Lewis肺癌抑制作用及机理的研究
5.Study on Recombinant Mutant Human Tumor Necrosis Factor Enhancing the Chemotherapeutic Effect of Cisplatin in the Mice with Lewis Lung Carcinoma and the Mechanism;重组改构人肿瘤坏死因子增强顺氯氨铂抑制小鼠Lewis肺癌的作用及机制研究
6.Construction of a Novel Human TNF α Mutant基因重组人肿瘤坏死因子-α突变体的构建
7.Studies on Tumor Targeting of Stealth Nanoparticles Loading Recombinant Human Tumor Necrosis Factor-alpha;重组人肿瘤坏死因子隐形纳米粒肿瘤靶向研究
8.Therapeutic effect of local rmhTNF plus cisplatin inoculation on patients with malignant effusion重组改构肿瘤坏死因子联合顺铂治疗恶性腹腔积液的效果
9.Construction of Recombinant Human Tumor Necrosis Factor-alpha Secreted Eukaryotic Expression Vector and its Expression on Chinese Hamster Ovary Cells重组人肿瘤坏死因子α分泌型真核表达载体的构建及表达
10.Effect of ~(131)I-labeled Recombinant Human Tumor Necrosis Factor-α on the Nude Mice Bearing Human Hepatoma碘-131标记重组人肿瘤坏死因子-α治疗荷人肝癌裸鼠的实验研究
11.Characterization, Expression and Extraction of Recombinant Humor Tumor Necrosis Factor α(rhTNFα) on Large Scale;重组人肿瘤坏死因子α（rhTNFα）的鉴定、表达及大规模提取的研究
12.The effects of p16 in the apoptosis of HepG2 Hepatocellular carcinoma cells induced by recombinant mutant human tumor necrosis factor (rmhTNF)p16在重组人肿瘤坏死因子诱导的HepG2肝癌细胞凋亡中的作用研究
13.DNA Residue Detection of Recombination Human Tumor Necrosis Factor(TNF)-related Apoptosis-inducing Ligand重组人肿瘤坏死因子相关凋亡诱导配体蛋白的DNA残留量检测
14.Expression of Tumor Necrosis Factor Alpha in Subcutaneous and Omental Adipose Tissues of Overweight Individuals;肿瘤坏死因子α在超重者脂肪组织中的表达
15.Studies on the Reversal Effect of Multidrug Resistance by Haloperidol and Recombinant Human Tumor Necrosis Factor rhTNF-NC and Its Mechanism;氟哌啶醇与新型人重组肿瘤坏死因子逆转肿瘤细胞耐药机制的研究
16.Effects of Recombinant Human Tumor Necrosis Factor-alpha on HL-60 Cell and Its Xenografts in Nude Mice;重组人肿瘤坏死因子-α对HL-60细胞及其裸鼠异种移植瘤的作用研究
17.Efficacy of rhTNFR:Fc on ventricular arrhythmia in rats with acute myocardial infarction in vivo重组人肿瘤坏死因子受体融合蛋白对大鼠急性心肌梗死室性心律失常的影响
18.TNF-a Gene Polymorphisms in Myasthenia Gravis;肿瘤坏死因子-a-308基因多态性在重症肌无力病人中的表达
相关短句/例句
recombinant mutant human tumor necrosis factor/therapeutic use重组改构人肿瘤坏死因子/治疗应用
3)rmhTNF-α重组改构人肿瘤坏死因子-α
1.Meanwhile, to examine the effects of rmhTNF-αcombined with anti-cancer agents cisplatin on human hepatocellular cancer cell SMMC-7721 to investigate possible mechanism of inhibiting cell proliferation and inducing apoptosis by rmhTNF-αcombined with cisplatin.目的:通过研究重组改构人肿瘤坏死因子-α(recombinant mutant human tumor necrosis factorα,rmhTNF-α)对人肝癌细胞SMMC-7721的体外作用,观察rmhTNF-α联合抗癌药物顺铂(cisplatin,DDP)对SMMC-7721细胞体外作用的影响,进一步阐明rmhTNF-α增加DDP抑制肿瘤细胞增殖及诱导凋亡的可能机制。
4)rhTNF-α重组人肿瘤坏死因子
1.To study the effects of recombinant human tumor necrosis factor-alpha ( rhTNF-α) on HL-60 cells in vitro and in vivo, MTT and colony forming assay were used to examine the effects of rhTNF-α on proliferation of HL-60 cells; AO/EB (acridine orange - ethidium bromide) staining, Annexin -V flow cytometry analysis and TUNEL assay were used to detect apoptotic cells .为了研究重组人肿瘤坏死因子-α(recombinanthumantumornecrosisfactor-alpha,rhTNF-α)在体外及体内对人髓系白血病细胞株HL-60细胞的作用,应用MTT法和集落形成试验测定HL-60细胞的增殖抑制,采用AO/EB荧光染色法、流式细胞术和TdT酶介导的缺口末端标记(TUNEL)法检测凋亡细胞;利用HL-60细胞裸鼠异种移植瘤模型观察给药后瘤体重量、组织病理的改变,并采用透射电镜以及TUNEL法检测瘤组织细胞的凋亡。
2.Purpose:It was investigated that the biological activi t ies of rhG-CSF,rhGM-CSF and rhTNF-α were determined by MTT method.目的 :对MTT法测定重组人粒细胞集落刺激因子 (rhG CSF)、重组人粒细胞 /巨噬细胞集落刺激因子 (rhGM CSF)、重组人肿瘤坏死因子 (rhTNF α)等基因工程细胞生长因子生物学活性进行方法学研究。
5)Recombinant human tumor necrosis factor-α重组人肿瘤坏死因子-α
1.Recombinant human tumor necrosis factor-αinhibits implanted gastric cancer of node mice via enhancing expression of death associated protein 3;死亡相关蛋白3参与重组人肿瘤坏死因子-α抑制裸鼠胃癌移植瘤的生长
6)rTNF人重组肿瘤坏死因子(rTNF)
延伸阅读
肿瘤坏死因子分子式：CAS号：性质：又称恶液质素(cachectin)，淋巴毒素(lymphotoxin；LT)。注射卡介苗短小棒状杆菌和酵母多糖等制剂，再以内毒素攻击在小鼠、大鼠和兔等多种动物的血清中出现的一种能引起肿瘤出血性坏死的活性成分。含有唾液酸和半乳糖胺的一种糖蛋白，分子量约150 000。根据其产生来源和结构不同，可分为TNF-α和TNF-β两类，前者有单核-巨噬细胞产生，后者有活化T细胞产生，现已有基因重组技术制备。两类TNF的基本生物活性相似，除具有杀伤肿瘤细胞外，还有免疫调节，参与发热和炎症的发生。大剂量TNF-α可引起恶液质，医疗上可单独或白细胞介素2联合用于治疗肿瘤。
